Ishikawa Osamu 石川治

… Alternative Names

ISHIKAWA Osamu 石川治

Less

Researcher Number	90168188
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2017 – 2019: 群馬大学, 大学院医学系研究科, 教授 2012 – 2015: 群馬大学, 医学(系)研究科(研究院), 教授 2012: 群馬大学, 大学院・医学系研究科, 教授 2010 – 2011: 群馬大学, 大学院・医学系研究科, 教授 2007: Gunma University, graduate school of medicine, Dermatology, Professor … More 2006: 群馬大学, 大学院医学系研究科, 教授 1999 – 2001: GUNMA UNIVERSITY, DRMATOLOGY, PROFESSOR, 医学部, 教授 1996 – 1998: 群馬大学, 医学部, 助教授 1994: 群馬大学, 医学部皮膚科, 助教授 1993 – 1994: 群馬大学, 医学部・皮膚科, 助教授 1993: 群馬大学, 医学部付属病院・皮膚科, 講師 1992: 群馬大学, 医学部附属病院(皮膚科), 講師 1990 – 1991: 群馬大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology
Keywords	Principal Investigator HHL / コラーゲン / 全身性強皮症 / 強皮症 / 三次元培養 / 線維化 / collagen / MMP-1 / 低酸素 / 分子間架橋 … More / シグナル伝達 / 線維芽細胞 / 皮膚線維化 / 間葉系幹細胞 / 石灰化 / ガドリニウム / 腎性全身性線維症 / 膠原病 / 治療 / ATP / 細胞外ATP / 皮膚硬化 / MAP kinase / phospholipase / TGF-beta / lipid mediators / extracellular matrix / signal trunsduction / fibrosis / 臨床 / 生理活性 / 発現制御 / 細胞・組織 / MAPキナーゼ / ホスホリパーゼ / TGF-β / 脂質メディエーター / 細胞外マトリックス / nitroglycerine / systemic sclerosis / wound model / fibroblast / three dimensional culture / MMP / コラゲナーゼ / ニトログリセリン / 創傷モデル / 繊維芽細胞 / 三次元 / INTERMOLECULAR CROSS-LINK / SCLERODRMA / COLLAGEN / 低栄養 / Lysyl oxidase / Three dimensional culture / Low seru concentration / Hypoxia / Systemic sclerosis / Histidinohydroxylsinonorleucine / histidinohydroxylysinonorleucine / mucopolysaccharides / Growth factor / fibroblasts / Three-dimensional culture / Neurofibromatosis / rasGTP蛋白 / L-ascorbic Acid 2-phosphate / 細胞増殖因子 / ムコ多糖 / 増殖因子 / 神経線維腫症 / エンドセリン / モデルマウス / 皮膚石灰化 … More Except Principal Investigator Fibroblasts / 線維芽細胞 / 紫外線 / グリコサミノグリカン / apoptosis / keratinocyte / knockout mouse / filaggrin / アポトーシス / 表皮細胞 / ノックアウトマウス / フィラグリン / Fibrosis / Growth factors / Remodeling / Allergic inflammation / Mast cells / ヒト肥満細胞 / 線維化 / 成長因子 / 肥満細胞 / リモデリング / アレルギー炎症 / Antioxidants / Collagen / Glycosaminoglycans / Antioxidant network / Oxidative stress / Photoaging / Ultraviolet light / 三次元培養 / 二糖分析 / 活性酸素 / 抗酸化剤 / コラーゲン / 抗酸化能 / 酸素ストレス / 光老化 / Competitive binding assay / Neurofibromatosis / Neurofibroma / Growth factor / ペプチド同定 / レックリングハウゼン病 / competitive binding assay / 神経線維腫症 / 神経線維腫 / 増殖因子 / ループスエリテマトーデス / 膠原病 / 光線過敏 / ヒアルロン酸 / デルマタン硫酸 / 病的線維化 / 硬化性皮膚疾患 / 二糖 / 限局性強皮症 Less

The role of extracellular ATP in the pathogenesis of skin sclerosis and vasculopathy in systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  Ishikawa Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
The mechanisms of skin fibrosis and calcification in nephrogenic systemic fibrosisPrincipal Investigator
- Principal Investigator
  
  Ishikawa Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
The establishment of gadolinium-induced skin fibrosis and calcification mice model.Principal Investigator
- Principal Investigator
  
  ISHIKAWA Osamu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Mechanism of skin fibrosis by lipid mediators and its clinical trialsPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Osamu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Reconstruction of human autologous skin using three dimensional culture and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Osamu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
新たな定量的測定法in vitro phototestによる光線過敏性の調査研究
- Principal Investigator
  
  古川福実
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Wakayama Medical University
Generation of filggrin-deficient mice and analysis o differentiation and apoptosis of keratinocytes
- Principal Investigator
  
  NEGISHI Izumi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
REGULATORY MECHANISM FOR THE FORMATION OF TRIVALENT CROSS-LINK (HHL) OF TYPE I COLLAGENS IN ACQUIRED CONNECTIVE TISSUE DISEASESPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Osamu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
限局性強皮症における皮膚グリコサミノグリカンの二糖分析に関する研究
- Principal Investigator
  
  樋口忠義
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Mutual reactions of human mast cells and fibroblasts in the regulation of remodering processof allergic inflammation
- Principal Investigator
  
  MIYACHI Yoshiki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  KYOTO UNIVERSITY
  Gunma University
A novel method for histidinohydroxylysinonorleucine measurement and its clinical aaplicationPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Osamu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University School of Medicine
Cell biological and biochemical study on the mechanism and oxidative regulation of photoaging
- Principal Investigator
  
  MIYACHI Yoshiki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Basic and clinical research on growth promoting factor for neurofibromaPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Osamu
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Basic Research and Clinical Application of the Growth Factor of Neurofibromatosis
- Principal Investigator
  
  HIDEKAZU Ishikawa
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University

All 2019 2017 2014 2013 2007 Other

All Journal Article Presentation

[Journal Article] The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor.2019
- Author(s)
  Perera LMB, Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Yokoyama Y, Ogino S, Torii R, Hosoi M, Ishikawa O, Motegi S
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 139 Pages: 890-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10205
[Journal Article] Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis2014
- Author(s)
  Motegi S, Okada E, Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Takeuchi Y, Monma F, Suzuki T, Ishikawa O
- Journal Title
  
  Experimental Dermatology
  
  Volume: 23 Issue: 9 Pages: 664-669
- DOI
  10.1111/exd.12500
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461662
[Journal Article] Extracelluler matrix gene expression altered by N-methylethanolamine in Human dermal fibroblasts2007
- Author(s)
  Masayoshi Yamanaka, Osamu Ishikawa
- Journal Title
  
  scar-keloid journal 1
  
  Pages: 45-49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591234
[Journal Article] ヒト線維芽細胞におけるMEA (N-metylethanolamine)の細胞外基質関連遺伝子制御機構2007
- Author(s)
  山中正義、石川治
- Journal Title
  
  瘢痕・ケロイド治療ジャーナル 1
  
  Pages: 45-49
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] Mechanistic insight into the extracellular ATP-induced IL-6 via purinergic receptor in systemic sclerosis dermal fibroblasts2017
- Author(s)
  Buddhini Perera, Akihiko Uchiyama, Akiko Sekiguchi, Chisako Fujwara, Osamu Ishikawa, Sei-ichiro Motegi
- Organizer
  2017 Society for Investigative Dermatology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10205
[Presentation] The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor2017
- Author(s)
  Buddhini Perera, Akiko Sekiguchi, Akihiko Uchiyama, Akihito Uehara, Chisako Fujwara, Sahori Yamazaki, Osamu Ishikawa, Sei-ichiro Motegi
- Organizer
  The 42nd annual meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10205
[Presentation] Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis2013
- Author(s)
  Motegi S, Okada E, Uchiyama A, Yamada K, Uehara A, Ogino S, Takeuchi Y, Ishikawa O
- Organizer
  International Investiagtive Dermatology
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-25461662
[Presentation] Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systeimc fibrosis2013
- Author(s)
  Motegi S, Ishikawa O
- Organizer
  International Investigative Dermatology
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-22591237
[Presentation] Antifibrotic actions of N-methylethanolamine (MEA) in human dermal fibroblasts2007
- Author(s)
  Yamanaka M, Ishikawa O
- Organizer
  Professor E. Carwile LeRoy Memorial Ihtemational Workshop on Scleroderma
- Place of Presentation
  Tokyo,Japan
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] ヒト皮膚線維芽細胞におけるMEA (N-methylethanolamine)の抗線維化作用について2007
- Author(s)
  山中正義、石川治
- Organizer
  第39回日本結合組織学会学術大会・第54回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] ヒト皮膚線維芽細胞におけるMEA(N-methylethanolamine)の抗線維化作用について2007
- Author(s)
  山中正義、石川治
- Organizer
  第39回日本結合組織学会学術大会・第54回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] Antifibrotic actions of N-methylethanolamine (MEA) in human dermal fibroblasts.2007
- Author(s)
  Yamanaka M, Ishikawa O
- Organizer
  Professor E. Carwile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] Antifibrotic actions of N-methylethanolamine (MEA) in human dermal fibroblasts2007
- Author(s)
  Masayoshi Yamanaka, Osamu Ishikawa
- Organizer
  Professor E. Carwile LeRoy Memorial International Workshop on Scleroderma 2007
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] Antifibrotic actions of N-methylethanolamine (MEA) in human dermal fibroblasts2007
- Author(s)
  MasayoshiYamanaka, Osamu Ishikawa
- Organizer
  The 39th Japanese Society for Connective Tissue Research & The 54Th Annual Meeting ofthe Japan Matrix Club
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591234
[Presentation] Role of Endothelin-1/Endothelin Receptor Signaling in Fibrosis and Calcification in Nephrogenic Systemic Fibrosis
- Author(s)
  Motegi S, Okada E, Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Takeuchi Y, Monma F, Suzuki T, Ishikawa O
- Organizer
  The 39th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  大阪
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25461662

1. OHNISHI Kazunori (60176948)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. HAYASHI Hiroaki (50008611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HORIUCHI Ryuya (90008342)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MIYACHI Yoshiki (30127146)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NEGISHI Izumi (60292611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ABE Masatoshi (80302462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HIDEKAZU Ishikawa (70008233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUROSAWA Motohiro (10170119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMANAKA Masayoshi (30323364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. 樋口忠義 (80272243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 古川福実 (40156964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大橋弘幸 (60233243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岩月啓氏 (80126797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 上出康二 (50176608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森田栄伸 (90182237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山蔭明生 (50106944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 茂木精一郎 (20420185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Ishikawa Osamu 石川 治

ISHIKAWA Osamu 石川 治

Research Projects

Research Products

Co-Researchers

The role of extracellular ATP in the pathogenesis of skin sclerosis and vasculopathy in systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of skin fibrosis and calcification in nephrogenic systemic fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The establishment of gadolinium-induced skin fibrosis and calcification mice model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of skin fibrosis by lipid mediators and its clinical trialsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reconstruction of human autologous skin using three dimensional culture and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新たな定量的測定法in vitro phototestによる光線過敏性の調査研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of filggrin-deficient mice and analysis o differentiation and apoptosis of keratinocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATORY MECHANISM FOR THE FORMATION OF TRIVALENT CROSS-LINK (HHL) OF TYPE I COLLAGENS IN ACQUIRED CONNECTIVE TISSUE DISEASESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

限局性強皮症における皮膚グリコサミノグリカンの二糖分析に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mutual reactions of human mast cells and fibroblasts in the regulation of remodering processof allergic inflammation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel method for histidinohydroxylysinonorleucine measurement and its clinical aaplicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell biological and biochemical study on the mechanism and oxidative regulation of photoaging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic and clinical research on growth promoting factor for neurofibromaPrincipal Investigator

Principal Investigator

Project Period (FY)

Ishikawa Osamu 石川治

ISHIKAWA Osamu 石川治