Mogami Tomoko 最上知子

… Alternative Names

MOGAMI Tomoko 最上知子

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Researcher Number	90174333
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生化学部, 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立医薬品食品衛生研究所, 生化学部, 客員研究員 2017 – 2020: 国立医薬品食品衛生研究所, 生化学部, 主任研究官 2016: 国立医薬品食品衛生研究所, 安全性予測評価部, 主任研究官 2014 – 2015: 国立医薬品食品衛生研究所, 生化学部, 部長 2013: 国立医薬品食品衛生研究所, 代謝生化学部, 部長 2008 – 2012: National Institute of Health Sciences, 機能生化学部, 室長 1998 – 2000: 国立医薬品食品衛生研究所, 代謝生化学部, 室長
Review Section/Research Field	Principal Investigator Environmental and hygienic pharmacy / Metabolomics / Environmental pharmacy / Drug development chemistry
Keywords	Principal Investigator VLDL / IL-1beta / NLRP3 / インフラマソーム / コレステロール / カーボンナノチューブ / RXR / 炎症 / 脂質 / 薬学 … More / スタチン / secretion / apolipoprotein B / 糖鎖 / 分泌 / アポリポプロティンB / 褐色脂肪細胞 / ベージュ細胞 / 有機スズ / 脂肪細胞褐色化 / 脂肪細胞分化 / 肥満抑制 / 白色脂肪細胞 / トリブチルスズ / ベージュ細胞分化 / 白色脂肪褐色化 / 白色脂肪組織 / RXRアゴニスト / IL-1β / ナノ材料 / PPARγ / ABCA1 / 選択的モジュレーター / HDL / LXR / 核内受容体 Less

The mechanism by which statins repress endogenous pathogenic crystal- or needle-like nanomaterial-induced inflammasome activation in macrophagesPrincipal Investigator
- Principal Investigator
  
  Nishimaki-Mogami Tomoko
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Health Sciences
RXR agonists and tributyltin have the ability to induce white-to-brown fat conversion.Principal Investigator
- Principal Investigator
  
  Nishimaki-Mogami Tomoko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Health Sciences
Control of multiwall carbon nanotube-induced inflammatory responses by cellular cholesterolPrincipal Investigator
- Principal Investigator
  
  NISHIMAKI-MOGAMI Tomoko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Institute of Health Sciences
Molecular basis for cell-type specific HDL generation by selective LXR modulatorsPrincipal Investigator
- Principal Investigator
  
  MOGAMI Tomoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
The role of N-linked glycosylation on the assembly and secretion of VLDLPrincipal Investigator
- Principal Investigator
  
  MOGAMI Tomoko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  National Institute of Health Sciences

All 2021 2020 2019 2016 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1β production by inhibiting the uptake of crystals by macrophages2021
- Author(s)
  Cui Hongyan、Soga Keisuke、Tamehiro Norimasa、Adachi Reiko、Hachisuka Akiko、Hirose Akihiko、Kondo Kazunari、Nishimaki-Mogami Tomoko
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 188 Pages: 114580-114580
- DOI
  10.1016/j.bcp.2021.114580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08406
[Journal Article] Statins repress multi-wall carbon nanotube-stimulated IL-1b release through inhibiting the uptake by macrophages2021
- Author(s)
  Nishimaki-Mogami T., Cui H., Soga K., Tamehiro N., Adachi R., Hachisuka A., Hirose A., Kondo K.
- Journal Title
  
  Toxicology Letters
  
  Volume: 350 Pages: S159-S160
- DOI
  10.1016/s0378-4274(21)00617-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08406
[Journal Article] Hepatocyte Nuclear Factor 4alpha Increases Liver-specific Human ATP- Binding Cassette Transporter A1 Expression and Cholesterol Efflux to ApoA-I in Response to Cholesterol Depletion2012
- Author(s)
  Ohoka N, Okuhira K, Cui H, Wu W, Sato R,Naito M, Nishimaki-Mogami T
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 32 Pages: 1005-1014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590164
[Journal Article] Hepatocyte Nuclear Factor 4alpha Increases Liver-specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to ApoA-I in Response to Cholesterol Depletion.2012
- Author(s)
  Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito M, Nishimaki-Mogami T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 32 Pages: 1005-1014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590164
[Journal Article] Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR.2011
- Author(s)
  Cui H, Okuhira K, Ohoka N, Naito M, Kagechika H, Hirose A, Nishimaki-Mogami T
- Journal Title
  
  Biochem Pharmacol. 81
  
  Pages: 819-824
- Data Source
  KAKENHI-PROJECT-20590116
[Journal Article] HDL産生トランスポーターABCA1の肝での二重転写制御機構生化学2010
- Author(s)
  最上(西巻)知子
- Journal Title
  
  82
  
  Pages: 852-856
- Data Source
  KAKENHI-PROJECT-20590116
[Journal Article] Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.2010
- Author(s)
  Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada JI, Naito M, Nishimaki-Mogami T
- Journal Title
  
  J Biol Chem 285
  
  Pages: 16369-16377
- Data Source
  KAKENHI-PROJECT-20590116
[Journal Article] HDL産生トランスポーターABCA1の肝での二重転写制御機構2010
- Author(s)
  最上(西巻)知子
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 852-856
- Data Source
  KAKENHI-PROJECT-20590116
[Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines2008
- Author(s)
  Nishimaki-Mogami T, et al
- Journal Title
  
  Biochem Pharmacol 76
  
  Pages: 1006-1013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590116
[Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.2008
- Author(s)
  Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira K, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Inoue K, Sawada J
- Journal Title
  
  Biochem Pharmacol 76
  
  Pages: 1006-1013
- Data Source
  KAKENHI-PROJECT-20590116
[Presentation] Statins repress cholesterol crystal-induced IL-1b production by decreasing the internalization of crystals by macrophages2021
- Author(s)
  Nishimaki-Mogami T, Cui H, Soga K, Tamehiro N, Adachi R, Hachisuka A, Hirose A, Kondo K
- Organizer
  ISA 2021, The 19th International Symposium on Atherosclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08406
[Presentation] Statins repress multi-wall carbon nanotube-stimulated IL-1b release through inhibiting the uptake by macrophages2021
- Author(s)
  Nishimaki-Mogami T, Cui H, Soga K, Tamehiro N, Adachi R, Hachisuka A, Hirose A, Kondo K
- Organizer
  EUROTOX 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08406
[Presentation] 多層カーボンナノチューブによるIL-1β産生を抑制する化合物の同定2020
- Author(s)
  最上(西巻)知子，崔紅艶, 曽我慶介, 為広紀正, 安達玲子, 蜂須賀暁子, 広瀬明彦，近藤一成
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08406
[Presentation] Discovery of an inhibitor of multiwall carbon nanotubes-stimulated IL-1β secretion via inflammasome activation.2019
- Author(s)
  Nishimaki-Mogami T, Cui H, Soga K, Adachi R, Tamehiro N, Hachisuka A, Kondo K, Hirose A
- Organizer
  EUROTOX 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08406
[Presentation] Identification of a sterol-responsive distal enhancer element for liver-specific ABCA1 gene expression. A novel mechanism for sterol-responsive hepatic ABCA1 gene regulation.2019
- Author(s)
  Ohoka N, Cui H, Tamehiro H, Adachi R, Okuhira K, Naito M, Kondo K, Nishimaki-Mogami T
- Organizer
  HDL Workshop: Structure, novel functions, and therapeutic applications
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08406
[Presentation] RXRアゴニストPA024はマウス白色脂肪組織の遺伝子発現を変化させ肥満を抑制する2016
- Author(s)
  最上-重本由香里、崔　紅艶、佐藤陽治、影近弘之、首藤紘一、最上(西巻)知子
- Organizer
  日本レチノイド研究会第27回学術集会
- Place of Presentation
  昭和薬科大学（東京都町田市）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-26460184
[Presentation] High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubes have abilities to induce IL-1beta secretion through NLRP3-dependent mechanism depending on their lengths2013
- Author(s)
  Nishimaki-Mogami T, Cui H, Wu W, Okuhira K, Naito M, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Miyazawa K, Hirose A
- Organizer
  Eurotox2013
- Place of Presentation
  Interlaken, Switzerland
- Year and Date
  2013-09-03
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] Mechanism underlying multiwall carbon nanotube-induced IL-1beta secretion2012
- Author(s)
  Nishimaki-Mogami T, Cui H, Okuhira K, Naito M, Suzuki K, Nishimura T, Hirose A
- Organizer
  EUROTOX 2012
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2012-06-19
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] Hepatocyte Nuclear Factor 4alpha(HNF4alpha) Regulates Liver-specific Human ATP-binding Cassette Protein A1 (ABCA1) Gene Expression in Response to Cholesterol Depletion2012
- Author(s)
  Ohoka N, Okuhira K, Cui H, Wu W, Naito M, Nishimaki-Mogami T
- Organizer
  ASBMB Symposium "Frontiers in Lipid Biology"
- Place of Presentation
  Banff, Canada
- Year and Date
  2012-09-05
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] 多層カーボンナノチューブはNLRP3活性化を介してIL-1β産生を促進する2011
- Author(s)
  最上(西巻)知子, 崔紅艶, 岩崎香里, 奥平桂一郎, 内藤幹彦, 鈴木和博, 広瀬明彦
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] 多層カーボンナノチューブによるIL-1β産生促進とその機構2011
- Author(s)
  最上(西巻)知子, 崔紅艶, 岩崎香里, 奥平桂一郎, 内藤幹彦, 鈴木和博, 広瀬明彦
- Organizer
  フォーラム2011衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] HDL産生トランスポーターABCA1のコレステロールによる肝型転写制御　－ミニシンポジウム「脂質ホメオスタシス：その破綻と疾患」2011
- Author(s)
  最上(西巻)知子
- Organizer
  第12回Pharmaco-Hematologyシンポジウム(招待講演)
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] 多層カーボンナノチューブによるIL-1β産生促進とその機構2011
- Author(s)
  最上（西巻）知子, 崔紅艶, 岩崎香里, 奥平桂一郎, 内藤幹彦, 鈴木和博, 広瀬明彦
- Organizer
  フォーラム2011　衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] HDL産生トランスポーターABCA1のコレステロールによる肝型転写制御-2011
- Author(s)
  最上(西巻)知子
- Organizer
  ミニシンポジウム「脂質ホメオスタシス:その破綻と疾患」第12回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  富山
- Year and Date
  2011-06-17
- Invited
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] Regulation of human hepatic ABCA1 gene expression by sterols2010
- Author(s)
  最上(西巻)知子
- Organizer
  第42回日本動脈硬化学会総会(シンポジウム)
- Data Source
  KAKENHI-PROJECT-20590116
[Presentation] Regulation of human hepatic ABCA1 gene expression by sterols2010
- Author(s)
  Tomoko Nishimaki-Mogami
- Organizer
  第42回日本動脈硬化学会総会シンポジウム
- Place of Presentation
  岐阜市
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-20590116
[Presentation] Liver X receptor(LXR)modulators : potential therapeutic agents for raising HDL levels and protecting against atherosclerosis2009
- Author(s)
  Tomoko Nishimaki-Mogami
- Organizer
  第41回日本動脈硬化学会総会シンポジウム
- Place of Presentation
  山口市
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20590116
[Presentation] Liver X receptor (LXR) modulators : potential therapeutic agents for raising HDL levels and protecting against atherosclerosis2009
- Author(s)
  最上(西巻)知子
- Organizer
  第41回日本動脈硬化学会総会(シンポジウム)
- Data Source
  KAKENHI-PROJECT-20590116
[Presentation] 核内レセプターと胆汁酸・脂質代謝2008
- Author(s)
  最上(西巻)知子
- Organizer
  第30回胆汁酸研究会サテライトシンポジウム
- Data Source
  KAKENHI-PROJECT-20590116
[Presentation] Hepatocyte Nuclear Factor 4alpha(HNF4alpha) Regulates Liver-specific Human ATP-binding Cassette Protein A1 (ABCA1) Gene Expression in Response to Cholesterol Depletion
- Author(s)
  Ohoka N, Okuhira K, Cui H, Wu W, Naito M, Nishimaki-Mogami T.
- Organizer
  ASBMB Symposium "Frontiers in Lipid Biology"
- Place of Presentation
  Banff
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] Mechanism underlying multiwall carbon nanotube-induced IL-1beta secretion.
- Author(s)
  Nishimaki-Mogami T, Cui H, Okuhira K, Naito M, Suzuki K, Nishimura T, Hirose A.
- Organizer
  EUROTOX 2012
- Place of Presentation
  Stockholm
- Data Source
  KAKENHI-PROJECT-23590164
[Presentation] High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubes have abilities to induce IL-1beta secretion through NLRP3-dependent mechanism, depending on their lengths
- Author(s)
  Nishimaki-Mogami T, Cui H, Wu W, Okuhira K, Naito M, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Miyazawa K, Hirose A
- Organizer
  Eurotox2013
- Place of Presentation
  Interlaken, Switzerland
- Data Source
  KAKENHI-PROJECT-23590164

1. OKUHIRA Keiichiro (10425671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results

Mogami Tomoko 最上 知子

MOGAMI Tomoko 最上 知子

Research Projects

Research Products

Co-Researchers

The mechanism by which statins repress endogenous pathogenic crystal- or needle-like nanomaterial-induced inflammasome activation in macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RXR agonists and tributyltin have the ability to induce white-to-brown fat conversion.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control of multiwall carbon nanotube-induced inflammatory responses by cellular cholesterolPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis for cell-type specific HDL generation by selective LXR modulatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of N-linked glycosylation on the assembly and secretion of VLDLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1β production by inhibiting the uptake of crystals by macrophages2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Statins repress multi-wall carbon nanotube-stimulated IL-1b release through inhibiting the uptake by macrophages2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatocyte Nuclear Factor 4alpha Increases Liver-specific Human ATP- Binding Cassette Transporter A1 Expression and Cholesterol Efflux to ApoA-I in Response to Cholesterol Depletion2012

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocyte Nuclear Factor 4alpha Increases Liver-specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to ApoA-I in Response to Cholesterol Depletion.2012

Author(s)

Journal Title

Data Source

[Journal Article] Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR.2011

Author(s)

Journal Title

Data Source

[Journal Article] HDL産生トランスポーターABCA1の肝での二重転写制御機構生化学2010

Author(s)

Journal Title

Data Source

[Journal Article] Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.2010

Author(s)

Journal Title

Data Source

[Journal Article] HDL産生トランスポーターABCA1の肝での二重転写制御機構2010

Author(s)

Journal Title

Data Source

[Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines2008

Author(s)

Journal Title

Data Source

[Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.2008

Author(s)

Journal Title

Data Source

[Presentation] Statins repress cholesterol crystal-induced IL-1b production by decreasing the internalization of crystals by macrophages2021

Author(s)

Organizer

Mogami Tomoko 最上知子

MOGAMI Tomoko 最上知子

[Presentation] HDL産生トランスポーターABCA1のコレステロールによる肝型転写制御　－ミニシンポジウム「脂質ホメオスタシス：その破綻と疾患」2011