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MATSUI Hiroaki  松井 宏晃

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MATUI Hiroaki  松井 宏晃

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Researcher Number 90181685
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2014: 聖マリアンナ医科大学, 医学部, 教授
2012 – 2013: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 教授
2010: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 教授
1998 – 2008: 聖マリアンナ医科大学, 医学部, 教授
1995 – 1997: 聖マリアンナ医科大学, 医学部, 講師
1989 – 1991: 聖マリアンナ医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Psychiatric science / Psychiatric science
Except Principal Investigator
Psychiatric science / Psychiatric science
Keywords
Principal Investigator
選択的スプライシング / ラット縫線核由来RN46A細胞 / 神経特異的抑制因子 / 抗うつ薬 / NF-Y / AP-2 / CREB / D_3ドーパミン(DA)受容体 / ヒト神経芽細胞腫SY-5Y細胞 / 逆転写・ポリメラーゼ連鎖(RT-PCR)反応 … More / long PCR法 / アルツハイマー病 / βアミロイド蛋白質前駆体遺伝子 / エクソンスキッピング / エクソンスプライシング促進配列 / エクソンスプライシング抑制配列 / モルフォリノオリゴヌクレオチド / 2'-0-Met RNA / セロトニン神経系 / クロマチン免疫沈降法 / セロトニン神経細胞特異的転写因子Pet-1 / Pet-1標的遺伝子 / 転写因子 / 遺伝子発現 / クロマチン沈降法 / β_1 ^-アドレナリン受容体 / 受容体調節機構 / 受容体遺伝子発現 / βーアドレナリン受容体 / 受容体遺伝子発現調節 / 抗うつ薬作用機序 / βアドレナリン受容体 / 受容体遺伝子発現調節機構 / beta_1-adrenergic receptor / antidepressant / receptor regulation / receptor gene expression / 5-HT_4受容体 / 5-HT_4受容体遺伝子 / セロトニン受容体 / セロトニン4S受容体 / セロトニン4L受容体 / アデニル酸シクラーゼ / β_1アドレナリン受容体遺伝子 / グルココルチコイド受容体 / 転写抑制 / β1アドレナリン受容体遺伝子 / デキサメサゾン / β1-adrenergic receptor / Glucocorticoid receptor / Transcriptional repression / Antidepressant / トリプトファン水酸化酵素2 / トリプトファン水酸化酵素1 / 転写制御領域 / 神経特異的抑制配列 / ヒストンデアセチラーゼ / ヒト肺小細胞癌HSP-77細胞 / ヒト神経芽細胞腫SH-SY5Y細胞 / セロトニン神経特異的転写因子 / ヒト脳型トリプトファン水酸化酵素 / ヒト抹消型トリプトファン水酸化酵素 / ラット縫線由来RN46A細胞 / セロトニン系神経細胞特異的転写因子 / Tryptophan hydroxylase 2 / Tryptophan hydroxylase 1 / Transcriptional regulation region / Rat serotonergic cell line RN46A / Neuron-restrictive silencer factor / Neuron-restrictive silencer element / Histone deacetylase … More
Except Principal Investigator
bHLH / GAP-43 / SNRI / E-box / eEF2 / 気分安定薬 / リチウム / 転写因子 / Math / Lithium / MATH / Transcription Factor / SSRI / NBD-F / dynamin / GTPase / ゲルシフトアッセイ / BHLH / Mod stabilizer / プロテオミクス / リン酸化 / MATH-2 / 転写因 / Mood stabilizer / Proteomics / Phosphorylation / ミルナシプラン / 薬物結合蛋白質 / milnacipran / binding protein / 時計遺伝子 / サーカディアンリズム Less
  • Research Projects

    (12 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (17 People)
  •  The identification of biomarker for the circadian rhythm of clock gene of the bipolar disorder

    • Principal Investigator
      Haga Toshiaki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Psychiatric science
    • Research Institution
      St. Marianna University School of Medicine
  •  Comprehensive identification of the Pet-1-target genes by chromatin immunoprecipitation assays in RN46A cells derived from the rat raphe nucleus.Principal Investigator

    • Principal Investigator
      MATSUI Hiroaki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Psychiatric science
    • Research Institution
      St. Marianna University School of Medicine
  •  The investigation to Dynamin-1 for new antidepressats binding protein

    • Principal Investigator
      OSADA Kenichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St.Marianna University School of Medicine
  •  アルツハイマー病新規治療戦略:前駆体遺伝子エクソン17破断によるAβ生成抑制機構Principal Investigator

    • Principal Investigator
      松井 宏晃
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Psychiatric science
    • Research Institution
      St.Marianna University School of Medicine
  •  The cloning and investigations for antidepressants affected protein with new chemical proteomics approach

    • Principal Investigator
      OSADA Kenichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St.Marianna University School of Medicine
  •  Investigation for MATH-2 overexpressed transgenic mice to mood disorders model mice

    • Principal Investigator
      OSADA Kenichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St.Marianna University School of Medicine
  •  Structural, functional and pormorphic analysis of the regulatory regions necessary for the expression of the human neuronal tryptophan hydroxylase gene.Principal Investigator

    • Principal Investigator
      MATSUI Hiroaki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St. Marianna University School of Medicine
  •  Investigation for matching bHLH overexpressed transgenic mice to mood disorders model mice

    • Principal Investigator
      OSAKA Kenichi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      St Marianna University School of Medicine
  •  The transcriptional regulation of the human β1-adrenergic receptor gene by stress-related transcription moleculesPrincipal Investigator

    • Principal Investigator
      MATSUI Hiroaki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St. Marianna University School of Medicine
  •  アデニル酸シクラーゼ促進性ヒト5-HT4受容体の遺伝子構造ならびに機能調節機構Principal Investigator

    • Principal Investigator
      松井 宏晃
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St. Marianna University School of Medicine
  •  ヒトD_3ドーパミン受容体アイソフォームの発現調節および細胞内情報伝達機構Principal Investigator

    • Principal Investigator
      松井 宏晃
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      St. Marianna University School of Medicine
  •  Structural Organization and Transcriptional Regulation of the Human beta_1-Adrenergic Receptor GenePrincipal Investigator

    • Principal Investigator
      MATSUI Hiroaki
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Psychiatric science
    • Research Institution
      ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE

All 2013 2012 2010 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity.2012

    • Author(s)
      Gentile MT, Nawa Y, Lunardi G, Florio T, Matsui H, Colucci-D'Amato L
    • Journal Title

      J. Neurochemistry

      Volume: Vol. 123、No.6 Pages: 963-970

    • DOI

      10.1111/jnc.12004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659548
  • [Journal Article] The Proteome Analysis to the rat brain protein after long-term lithium2006

    • Author(s)
      M. Nakano, K. Osada, A. Misonoo, K. Takahashi, M. Takahashi, Y. Ogawa, S. Kanai, D. Tanaka, T. Hishinuma, Y. Sasuga, H. Nishikawa, H, Matsui, M. Yamada, M. Asakura
    • Journal Title

      Neurochemistry 45

      Pages: 544-544

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591313
  • [Presentation] Transcriptional regulation of the human serotonin type 4(5-ht4) receptor gene:identification and characterization of novel promoter and enhancer2013

    • Author(s)
      Yukino Nawa, Masanori Ootaki, Rie Kuwabara, Tomoko Hiroi, Ryoya Takahashi, Hiroaki Matsui
    • Organizer
      北米神経科学会
    • Place of Presentation
      サンディエゴ(米国)
    • Data Source
      KAKENHI-PROJECT-24659548
  • [Presentation] ヒトセロトニン4受容体遺伝子発現調節機構:ERG、EGRおよびNF1による調節2013

    • Author(s)
      那和雪乃、大滝正則、桑原理恵、廣井朋子、高橋良哉、松井宏晃
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Data Source
      KAKENHI-PROJECT-24659548
  • [Presentation] Fluvoxamine and Sigma-1 Receptor Agonists Dehydroepiandrosterone (DHEA)-sulfate Induces the Ser473-phosphorylation of Akt-1 in PC12 Cells.2010

    • Author(s)
      Osada K, Haga T, Ogawa Y, Matsui H, Nakano M, Asakura M, Yamaguchi N
    • Organizer
      41th Annual Meeting of Neuroscience
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-20591380
  • [Presentation] Chronic trifluoperazine treatment increased P-glycoprotein in the rat brain.2009

    • Author(s)
      Osada K, Ogawa Y, Matsui H, Haga T, Nakano M, Takahashi K, Fujiwara K, Yanagida T, Kanai S
    • Organizer
      40th Annual Meeting of Neuroscience
    • Year and Date
      2009-10-19
    • Data Source
      KAKENHI-PROJECT-20591380
  • [Presentation] Regulation of the human tryptophan hydroxylase-2 gene promoter activity in immortalized serotonergic RN46A cells.2008

    • Author(s)
      Hiroaki Matsui
    • Organizer
      Serotonin Club Satellite Meeting(the EPHAR 2008Congress Satellite Meeting)
    • Place of Presentation
      オックスフォード、英国
    • Year and Date
      2008-07-18
    • Data Source
      KAKENHI-PROJECT-19659294
  • [Presentation] Regulation of the human tryptophan hydroxylase-2 gene promoter activity in immortalized serotonergic RN46A cells2007

    • Author(s)
      Hiroaki Matsui
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      米国、San Diego
    • Data Source
      KAKENHI-PROJECT-19659294
  • 1.  OSADA Kenichi (20233504)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 3 results
  • 2.  ASAKURA Mikio (70103504)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 3.  HIROI Tomoko (20238398)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  INO Miyuki (20203218)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  YAMADA Mituhiko (60240040)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  KIDA Satoshi (80301547)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KATOU Tomohiro (80233807)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SASUGA Yasuo (60308450)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MIYOSHI Hiroshi (80322519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MISONOO Atushi (20410128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  GAWA Yuriko (90449398)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  TANAKA Daisuke (80410124)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  NAWA Yukino (10549786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  KANEKO Rituko (00161183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Haga Toshiaki (80535625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  長谷川 浩 (80288183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  中野 三穂 (90621574)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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