isizaka yukihito 石坂幸人

… Alternative Names

ISHIZAKA Yukihito 石坂幸人

石坂幸人イシザカユキヒト

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Researcher Number	90184514
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立国際医療研究センター, 研究所, 副所長・難治性疾患研究部長
Affiliation (based on the past Project Information) *help	2012: 独立行政法人国立国際医療研究センター, 難治性疾患研究部, 部長 2010 – 2011: 国立国際医療研究センター, 難治性疾患研究部, 部長 2007: Research Institute, International Medical Center of Japan, 難治性疾患研究部, 部長 1990 – 1991: 国立がんセンター研究所, 発がん研究部, 室長
Review Section/Research Field	Principal Investigator Virology
Keywords	Principal Investigator スパイク蛋白質 / SARS-CoV / MARCKS / シェデイング / TNF-α変換酵 / 呼吸器重症化機構 / ムチン / TCAE / 呼吸器系重症化 / 細胞内ドメイン … More / プロモーター領域 / MUC5AC / Smad / TGF-b / NL63-CoV / 2型アンギオテンシン変換酵素 / 重症急性呼吸器症候群ウイルス / PAI-1 / 炎症 / 細胞内シグナル / RTーPCR / キメラ遺伝子 / 甲状腺腫瘍 / ret癌遺伝子 … More Except Principal Investigator 食品中発がん物質ヘテロサイクリックアミン / PCRーSSCP法 / アンチセンスRNA / バキュロウイルス / DNA修復 / DNAミスマッチ / WT遺伝子 / ウサギ腎芽腫 / p53遺伝子 / ras遺伝子 / ラット腎細胞がん / ラット大腸がん / IQによる扁平上皮がん / in vitro自然悪性化 / 放射線間接照射とがん遺伝子 / プロテインホスファタ-ゼとがん化 / Haーras活性化G→T変異 / MeIQによる扁平上皮がん Less

Mode of severe respiratory failure by SARS-CoVPrincipal Investigator
- Principal Investigator
  
  ISHIZAKA Yukihito
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Research Institute, International Medical Center of Japan
レニナンギオテンシン系と呼吸器感染症重症化のクロストークPrincipal Investigator
- Principal Investigator
  
  石坂幸人
- Project Period (FY)
  2007
- Research Institution
  Research Institute, International Medical Center of Japan
実験動物がんのがん遺伝子
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
ヒトDNAミスマッチ修復機構の解明とその発癌への関与
- Principal Investigator
  
  藤井裕之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nippon Medical School
甲状腺癌におけるret癌遺伝子Principal Investigator
- Principal Investigator
  
  石坂幸人
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
実験動物がんのがん遺伝子
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2013 2012 2011 2010 2008 2007

All Journal Article Presentation Book

[Book] Protein Kinases / Book 1 : Regulation of retrotransposition of long interspersed element-1 by mitogen-activated protein kinases.2012
- Author(s)
  Ishizaka Y, Okudaira N, Okamura T
- Publisher
  InTech - Open Access Publisher.
- Data Source
  KAKENHI-PROJECT-22390094
[Book] Regulation of retrotransposition of long interspersed element-1 by mitogenactivated protein kinases. In Gabriela Da Silva Xavier (ed), Protein Kinases/Book 1, InTech-Open Access Publisher, Croatia2012
- Author(s)
  Ishizaka Y, Okudaira N, Okamura T
- Total Pages
  10
- Publisher
  InTec
- Data Source
  KAKENHI-PROJECT-22390094
[Book] 「細胞」 HIV-1感染に伴う染色体異常2007
- Author(s)
  星野重樹、志村まり、石坂幸人
- Total Pages
  5
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-30281687
[Journal Article] DNA damage aids human immunodeficiency virus type 1 infection by overcoming integrase inhibition.2013
- Author(s)
  Koyama T, Sun B, Tokunaga K, Tatsumi M, Y Ishizaka
- Journal Title
  
  Retrovirology
  
  Volume: 10 Pages: 21-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Scanning protein analysis of electrofocusing gels using X-ray fluorescence.2012
- Author(s)
  Matsuyama S, Matsunaga A, Sakamoto S, Iida Y, Suzuki Y, Ishizaka Y, Yamauchi K, Ishikawa T, Shimura M.
- Journal Title
  
  Metallomics
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide2012
- Author(s)
  Koyama T, Shimura M, Minemoto Y, Nohara S, Shibata S, Iida Y, Iwashita S, Hasegawa M, Kurabayashi T, Hamada H, Kono K, Honda E, Aoki I, Ishizaka Y
- Journal Title
  
  J Control Release
  
  Volume: 159 Pages: 413-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation2012
- Author(s)
  Shimura M, Toyoda Y, Iijima K, Kinomoto M, Tokunaga K, Yoda K, Yanagida M, Sata T, Ishizaka Y
- Journal Title
  
  J Cell Biol
  
  Volume: 194 Pages: 721-735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus.2012
- Author(s)
  Hatakeyama S, Ishizaka Y, Kirikae T, Sasazuki S, Miyoshi-Akiyama T
- Journal Title
  
  J. Virol
  
  Volume: 86(21) Pages: 11745-53
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus.2012
- Author(s)
  Fukushi M, Yoshinaka Y, Matsuoka Y, Hatakeyama S, Ishizaka Y, Kirikae T, Sasazuki S, Miyoshi-Akiyama T.
- Journal Title
  
  J. Virol.
  
  Volume: 86 Pages: 11745-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Activation and mechanism of endogenous retroelement in intractable diseases2012
- Author(s)
  Okudaira N, Ishizaka Y
- Journal Title
  
  Seikagaku.
  
  Volume: 84 Pages: 870-874
- NAID
  10031122397
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Modes of retrotransposition of long interspersed element-1 by environmental factors.2012
- Author(s)
  Ishizaka Y, Okudaira N, Tamura M, Iijima K, Shimura M, Goto M, Okamura T
- Journal Title
  
  Front Microbiol
  
  Volume: 3 Pages: 191-191
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.2012
- Author(s)
  Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsnnaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y.
- Journal Title
  
  Oncogene
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 12011
- Author(s)
  Taneichi D, Iijima K, Doi A, Koyama T, Minemoto Y, Tokunaga K, Shimura M, Kano S, Ishizaka Y
- Journal Title
  
  J Neuroimmune Pharmacol
  
  Volume: 6 Pages: 177-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7, 12-dimethylbenz [a] anthracene and 12-O-tetradecanoylphorbol-13-acetate2011
- Author(s)
  Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 2000-2006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] SCFβ (TrCP) mediates stress-activated MAPK-induced Cdc25B degradation2011
- Author(s)
  Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RY, Yamashita K
- Journal Title
  
  J Cell Sci
  
  Volume: 124 Pages: 2816-1825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds.2010
- Author(s)
  Haga S, Nagata N, Okamura T, Yamamoto N, Sata T, Yamamoto, N, Sasazuki T, Ishizaka Y.
- Journal Title
  
  Antiviral Res.
  
  Volume: 85 Pages: 551-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390094
[Journal Article] Immunodeficiency Virus Type-1 Vpr Inhibits Axonal outgrowth through induction of mitochondrial dysfunction.2008
- Author(s)
  Kitayama H., Miura Y., Ando Y., Hoshino S., Ishizaka Y., and Koyanagi Y
- Journal Title
  
  J.Virology 82
  
  Pages: 2528-2542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-30281687
[Presentation] がん化におけるレトロトランスポジションの役割と機序症2012
- Author(s)
  石坂幸人
- Organizer
  第1回新LRI研究報告会
- Place of Presentation
  東京
- Year and Date
  2012-08-31
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] レトロトランスポジションの制御異常による疾病の発症2012
- Author(s)
  石坂幸人、岡村匡史
- Organizer
  第36回阿蘇シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2012-08-03
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] The small molecule compound as ACE2 activator suppressed pulmonary arterial hypertension.2012
- Author(s)
  Shiori Haga, Haruka Tsuchiya, Kaoru Hara, Akihiro Doi, Akio Mimori, Yukihito Ishizaka.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Possible mode of neurocognitive disorder in HIV-1 positive patients2012
- Author(s)
  Ishizaka Y
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Differential DNA methylation patterns in Non-Hodgkin lymphomas with and without HIV infection.2012
- Author(s)
  松永章弘, 比島恒和, 志村まり, 田中紀子), 望月眞), 石坂幸人, 萩原將太郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Involvement of retrotransposition of long interspersed elementl in DMBA/TPA induced skin tumorigenesis2012
- Author(s)
  奥平准之、石坂幸人
- Organizer
  第71回日本癌学会年会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] レトロトランスポジションの制御異常による疾病の発症2012
- Author(s)
  石坂幸人、奥平准之、飯島健太、岡村匡史
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Long interspersed element-1 is differentially regulated by environmental carcinogens via the aryl hydrocarbon receptor.2012
- Author(s)
  石坂幸人、奥平准之
- Organizer
  第71回日本癌学会年会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation2011
- Author(s)
  Shimura M, Toyoda Y, Iijima K, Kinomoto M, Tokunaga K, Yoda K, Yanagida M, Sata T, Ishizaka Y
- Organizer
  The 6th German-Japanese HIV-1 Symposium
- Place of Presentation
  Bohoem/Germany
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Establishment of mouse system for monitoring retrotransposition of human LINE-1 and its application of carcinogenesis experiments2011
- Author(s)
  Ishizaka Y, Noriyuki O, Goto M, Okamura T
- Organizer
  The 34 Annual Meeting of the Molecular Biology Sosicety of Japan. Yokohama
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Responsible epitopes of inhibitory autoantibodies to angiotensin-converting enzyme 2 in rheumatic vasculopathies2011
- Author(s)
  Haga S, Takahashi Y, Ishizaka Y, Mimori A
- Organizer
  ヨーロッパリウマチ学会
- Place of Presentation
  London, United Kingdom
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] HIV-1 associated neurocognitive disorder by retrotranspositionby Vpr2011
- Author(s)
  Ishizaka Y, Okudaira N, Oka S, Okamura T
- Organizer
  The 6th German-Japanese HIV-1 Symposium
- Place of Presentation
  Bohoem/Germany
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Neurocognitive disorder by Vpr-induced retrotransposition of LINE-12011
- Author(s)
  Ishizaka Y, Okudaira N, Oka S, Okamura T
- Organizer
  The 12th Kumamoto AIDS seminar GCOE Joint International symposium. Kumamoto
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] Retrotransposition of long interspersed nucleotide element 1 by food-born carcinogens2011
- Author(s)
  Ishizaka Y, Noriuku O, Ochiai M, Nakagama H
- Organizer
  The 70^<th> Annual Meeting of the Japanese Cancer Association. Nagoya
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] HIV-1アクセサリー蛋白質Vprの陰と陽2011
- Author(s)
  石坂幸人
- Organizer
  第13回白馬シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390094
[Presentation] SARS-CoV感染によるTACE活性化はACE2細胞内ドメインを介して生じる2008
- Author(s)
  芳賀しおり, 笹月健彦, 石坂幸人
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-30281687

1. 長尾美奈子 (40100151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 中村敏一 (00049397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 津田洋幸 (10163809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 江角浩安 (70160364)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 横路謙次郎 (70034618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 石川隆俊 (30085633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤井裕之 (10173395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高橋秀実 (40221361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岡崎太郎 (30060354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高橋雅英 (40183446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 嶋田耕育 (50634185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

isizaka yukihito 石坂 幸人

ISHIZAKA Yukihito 石坂 幸人

石坂 幸人 イシザカ ユキヒト

Research Projects

Research Products

Co-Researchers

Mode of severe respiratory failure by SARS-CoVPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

レニナンギオテンシン系と呼吸器感染症重症化のクロストークPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Institution

実験動物がんのがん遺伝子

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ヒトDNAミスマッチ修復機構の解明とその発癌への関与

Principal Investigator

Project Period (FY)

Research Category

Research Institution

甲状腺癌におけるret癌遺伝子Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

実験動物がんのがん遺伝子

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Protein Kinases / Book 1 : Regulation of retrotransposition of long interspersed element-1 by mitogen-activated protein kinases.2012

Author(s)

Publisher

Data Source

[Book] Regulation of retrotransposition of long interspersed element-1 by mitogenactivated protein kinases. In Gabriela Da Silva Xavier (ed), Protein Kinases/Book 1, InTech-Open Access Publisher, Croatia2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 「細胞」 HIV-1感染に伴う染色体異常2007

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] DNA damage aids human immunodeficiency virus type 1 infection by overcoming integrase inhibition.2013

Author(s)

Journal Title

Data Source

[Journal Article] Scanning protein analysis of electrofocusing gels using X-ray fluorescence.2012

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide2012

Author(s)

Journal Title

Data Source

[Journal Article] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation2012

Author(s)

Journal Title

Data Source

[Journal Article] Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus.2012

Author(s)

Journal Title

Data Source

[Journal Article] Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus.2012

Author(s)

Journal Title

Data Source

[Journal Article] Activation and mechanism of endogenous retroelement in intractable diseases2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Modes of retrotransposition of long interspersed element-1 by environmental factors.2012

isizaka yukihito 石坂幸人

ISHIZAKA Yukihito 石坂幸人

石坂幸人イシザカユキヒト