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isizaka yukihito  石坂 幸人

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ISHIZAKA Yukihito  石坂 幸人

石坂 幸人  イシザカ ユキヒト

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Researcher Number 90184514
Other IDs
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立国際医療研究所, 副所長
Affiliation (based on the past Project Information) *help 2012: 独立行政法人国立国際医療研究センター, 難治性疾患研究部, 部長
2010 – 2011: 国立国際医療研究センター, 難治性疾患研究部, 部長
2007: Research Institute, International Medical Center of Japan, 難治性疾患研究部, 部長
1990 – 1991: 国立がんセンター研究所, 発がん研究部, 室長
Review Section/Research Field
Principal Investigator
Virology
Keywords
Principal Investigator
スパイク蛋白質 / SARS-CoV / MARCKS / シェデイング / TNF-α変換酵 / 呼吸器重症化機構 / ムチン / TCAE / 呼吸器系重症化 / 細胞内ドメイン … More / プロモーター領域 / MUC5AC / Smad / TGF-b / NL63-CoV / 2型アンギオテンシン変換酵素 / 重症急性呼吸器症候群ウイルス / PAI-1 / 炎症 / 細胞内シグナル / RTーPCR / キメラ遺伝子 / 甲状腺腫瘍 / ret癌遺伝子 … More
Except Principal Investigator
食品中発がん物質ヘテロサイクリックアミン / PCRーSSCP法 / アンチセンスRNA / バキュロウイルス / DNA修復 / DNAミスマッチ / WT遺伝子 / ウサギ腎芽腫 / p53遺伝子 / ras遺伝子 / ラット腎細胞がん / ラット大腸がん / IQによる扁平上皮がん / in vitro自然悪性化 / 放射線間接照射とがん遺伝子 / プロテインホスファタ-ゼとがん化 / Haーras活性化G→T変異 / MeIQによる扁平上皮がん Less
  • Research Projects

    (6 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (11 People)
  •  Mode of severe respiratory failure by SARS-CoVPrincipal Investigator

    • Principal Investigator
      ISHIZAKA Yukihito
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  レニナンギオテンシン系と呼吸器感染症重症化のクロストークPrincipal Investigator

    • Principal Investigator
      石坂 幸人
    • Project Period (FY)
      2007
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  実験動物がんのがん遺伝子

    • Principal Investigator
      長尾 美奈子
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  ヒトDNAミスマッチ修復機構の解明とその発癌への関与

    • Principal Investigator
      藤井 裕之
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nippon Medical School
  •  甲状腺癌におけるret癌遺伝子Principal Investigator

    • Principal Investigator
      石坂 幸人
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  実験動物がんのがん遺伝子

    • Principal Investigator
      長尾 美奈子
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2013 2012 2011 2010 2008 2007

All Journal Article Presentation Book

  • [Book] Protein Kinases / Book 1 : Regulation of retrotransposition of long interspersed element-1 by mitogen-activated protein kinases.2012

    • Author(s)
      Ishizaka Y, Okudaira N, Okamura T
    • Publisher
      InTech - Open Access Publisher.
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Book] Regulation of retrotransposition of long interspersed element-1 by mitogenactivated protein kinases. In Gabriela Da Silva Xavier (ed), Protein Kinases/Book 1, InTech-Open Access Publisher, Croatia2012

    • Author(s)
      Ishizaka Y, Okudaira N, Okamura T
    • Total Pages
      10
    • Publisher
      InTec
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Book] 「細胞」 HIV-1感染に伴う染色体異常2007

    • Author(s)
      星野 重樹、志村 まり、石坂 幸人
    • Total Pages
      5
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-30281687
  • [Journal Article] DNA damage aids human immunodeficiency virus type 1 infection by overcoming integrase inhibition.2013

    • Author(s)
      Koyama T, Sun B, Tokunaga K, Tatsumi M, Y Ishizaka
    • Journal Title

      Retrovirology

      Volume: 10 Pages: 21-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Scanning protein analysis of electrofocusing gels using X-ray fluorescence.2012

    • Author(s)
      Matsuyama S, Matsunaga A, Sakamoto S, Iida Y, Suzuki Y, Ishizaka Y, Yamauchi K, Ishikawa T, Shimura M.
    • Journal Title

      Metallomics

      Volume: (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide2012

    • Author(s)
      Koyama T, Shimura M, Minemoto Y, Nohara S, Shibata S, Iida Y, Iwashita S, Hasegawa M, Kurabayashi T, Hamada H, Kono K, Honda E, Aoki I, Ishizaka Y
    • Journal Title

      J Control Release

      Volume: 159 Pages: 413-418

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation2012

    • Author(s)
      Shimura M, Toyoda Y, Iijima K, Kinomoto M, Tokunaga K, Yoda K, Yanagida M, Sata T, Ishizaka Y
    • Journal Title

      J Cell Biol

      Volume: 194 Pages: 721-735

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus.2012

    • Author(s)
      Hatakeyama S, Ishizaka Y, Kirikae T, Sasazuki S, Miyoshi-Akiyama T
    • Journal Title

      J. Virol

      Volume: 86(21) Pages: 11745-53

    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus.2012

    • Author(s)
      Fukushi M, Yoshinaka Y, Matsuoka Y, Hatakeyama S, Ishizaka Y, Kirikae T, Sasazuki S, Miyoshi-Akiyama T.
    • Journal Title

      J. Virol.

      Volume: 86 Pages: 11745-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Activation and mechanism of endogenous retroelement in intractable diseases2012

    • Author(s)
      Okudaira N, Ishizaka Y
    • Journal Title

      Seikagaku.

      Volume: 84 Pages: 870-874

    • NAID

      10031122397

    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Modes of retrotransposition of long interspersed element-1 by environmental factors.2012

    • Author(s)
      Ishizaka Y, Okudaira N, Tamura M, Iijima K, Shimura M, Goto M, Okamura T
    • Journal Title

      Front Microbiol

      Volume: 3 Pages: 191-191

    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.2012

    • Author(s)
      Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsnnaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y.
    • Journal Title

      Oncogene

      Volume: (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 12011

    • Author(s)
      Taneichi D, Iijima K, Doi A, Koyama T, Minemoto Y, Tokunaga K, Shimura M, Kano S, Ishizaka Y
    • Journal Title

      J Neuroimmune Pharmacol

      Volume: 6 Pages: 177-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7, 12-dimethylbenz [a] anthracene and 12-O-tetradecanoylphorbol-13-acetate2011

    • Author(s)
      Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 2000-2006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] SCFβ (TrCP) mediates stress-activated MAPK-induced Cdc25B degradation2011

    • Author(s)
      Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RY, Yamashita K
    • Journal Title

      J Cell Sci

      Volume: 124 Pages: 2816-1825

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds.2010

    • Author(s)
      Haga S, Nagata N, Okamura T, Yamamoto N, Sata T, Yamamoto, N, Sasazuki T, Ishizaka Y.
    • Journal Title

      Antiviral Res.

      Volume: 85 Pages: 551-555

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Journal Article] Immunodeficiency Virus Type-1 Vpr Inhibits Axonal outgrowth through induction of mitochondrial dysfunction.2008

    • Author(s)
      Kitayama H., Miura Y., Ando Y., Hoshino S., Ishizaka Y., and Koyanagi Y
    • Journal Title

      J.Virology 82

      Pages: 2528-2542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-30281687
  • [Presentation] がん化におけるレトロトランスポジションの役割と機序症2012

    • Author(s)
      石坂幸人
    • Organizer
      第1回新LRI研究報告会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-31
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] レトロトランスポジションの制御異常による疾病の発症2012

    • Author(s)
      石坂幸人、岡村匡史
    • Organizer
      第36回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2012-08-03
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] The small molecule compound as ACE2 activator suppressed pulmonary arterial hypertension.2012

    • Author(s)
      Shiori Haga, Haruka Tsuchiya, Kaoru Hara, Akihiro Doi, Akio Mimori, Yukihito Ishizaka.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Possible mode of neurocognitive disorder in HIV-1 positive patients2012

    • Author(s)
      Ishizaka Y
    • Organizer
      第14回 白馬シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Differential DNA methylation patterns in Non-Hodgkin lymphomas with and without HIV infection.2012

    • Author(s)
      松永章弘, 比島恒和, 志村まり, 田中紀子), 望月眞), 石坂幸人, 萩原將太郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Involvement of retrotransposition of long interspersed elementl in DMBA/TPA induced skin tumorigenesis2012

    • Author(s)
      奥平准之、石坂幸人
    • Organizer
      第71回日本癌学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] レトロトランスポジションの制御異常による疾病の発症2012

    • Author(s)
      石坂幸人、奥平准之、飯島健太、岡村匡史
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Long interspersed element-1 is differentially regulated by environmental carcinogens via the aryl hydrocarbon receptor.2012

    • Author(s)
      石坂幸人、奥平准之
    • Organizer
      第71回日本癌学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation2011

    • Author(s)
      Shimura M, Toyoda Y, Iijima K, Kinomoto M, Tokunaga K, Yoda K, Yanagida M, Sata T, Ishizaka Y
    • Organizer
      The 6th German-Japanese HIV-1 Symposium
    • Place of Presentation
      Bohoem/Germany
    • Year and Date
      2011-11-20
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Establishment of mouse system for monitoring retrotransposition of human LINE-1 and its application of carcinogenesis experiments2011

    • Author(s)
      Ishizaka Y, Noriyuki O, Goto M, Okamura T
    • Organizer
      The 34 Annual Meeting of the Molecular Biology Sosicety of Japan. Yokohama
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Responsible epitopes of inhibitory autoantibodies to angiotensin-converting enzyme 2 in rheumatic vasculopathies2011

    • Author(s)
      Haga S, Takahashi Y, Ishizaka Y, Mimori A
    • Organizer
      ヨーロッパリウマチ学会
    • Place of Presentation
      London, United Kingdom
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] HIV-1 associated neurocognitive disorder by retrotranspositionby Vpr2011

    • Author(s)
      Ishizaka Y, Okudaira N, Oka S, Okamura T
    • Organizer
      The 6th German-Japanese HIV-1 Symposium
    • Place of Presentation
      Bohoem/Germany
    • Year and Date
      2011-11-20
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Neurocognitive disorder by Vpr-induced retrotransposition of LINE-12011

    • Author(s)
      Ishizaka Y, Okudaira N, Oka S, Okamura T
    • Organizer
      The 12th Kumamoto AIDS seminar GCOE Joint International symposium. Kumamoto
    • Place of Presentation
      Kumamoto
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] Retrotransposition of long interspersed nucleotide element 1 by food-born carcinogens2011

    • Author(s)
      Ishizaka Y, Noriuku O, Ochiai M, Nakagama H
    • Organizer
      The 70^<th> Annual Meeting of the Japanese Cancer Association. Nagoya
    • Place of Presentation
      Nagoya
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] HIV-1アクセサリー蛋白質Vprの陰と陽2011

    • Author(s)
      石坂幸人
    • Organizer
      第13回白馬シンポジウム
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22390094
  • [Presentation] SARS-CoV感染によるTACE活性化はACE2細胞内ドメインを介して生じる2008

    • Author(s)
      芳賀 しおり, 笹月 健彦, 石坂 幸人
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-30281687
  • 1.  長尾 美奈子 (40100151)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  中村 敏一 (00049397)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  津田 洋幸 (10163809)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  江角 浩安 (70160364)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  横路 謙次郎 (70034618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  石川 隆俊 (30085633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  藤井 裕之 (10173395)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  高橋 秀実 (40221361)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  岡崎 太郎 (30060354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高橋 雅英 (40183446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  嶋田 耕育 (50634185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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