Ichinose Hiroshi 一瀬宏

… Alternative Names

ICHINOSE Hiroshi 一瀬宏

一瀬宏イチノセヒロシ

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Researcher Number	90192492
Other IDs
External Links
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 東京工業大学, 生命理工学院, 教授 2017 – 2018: 東京工業大学, 生命理工学研究科, 教授 2015: 東京工業大学, 生命理工学研究科, 教授 2015: 東京工業大学, 大学院生命理工学研究科, 教授 2011: 東京工業大学, 生命理工学研究科, 教授 … More 2009 – 2011: 東京工業大学, 大学院・生命理工学研究科, 教授 2005: 東京工業大学, 大学院・生命理工学研究科, 教授 2002 – 2003: 東京工業大学, 大学院・生命理工学研究科, 教授 2000 – 2001: Fujita Health University, Institute for Comprehensive Medical Science, Professor, 総合医科学研究所, 教授 1998 – 1999: 藤田保健衛生大学, 総合医科学研究所, 助教授 1993: Fujita Health University, Institute for Comprehensive Medical Science (Neurochem, 総合医科学研究所・神経化学, 講師 1992: 藤田保健衛生大学, 総合医科学研究所, 助手 1991: 藤田保健衛生大学, 総合医科学研究所(神経化学), 助手 1989 – 1990: 名古屋大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological Sciences / Neuroscience in general / Neuroscience in general Except Principal Investigator General pharmacology / Basic Section 55060:Emergency medicine-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Pathological medical chemistry / Psychiatric science
Keywords	Principal Investigator チロシン水酸化酵素 / ドーパミン / カテコールアミン / ドーパミンニューロン / 大脳基底核 / ビオプテリン / Nurr1 / dopaminergic neuron / tyrosine hydroxylase / Cre-loxP … More / Cre-ERT / 条件付き遺伝子破壊 / 脳神経疾患 / パーキンソン病 / ドパミン受容体 / ドパミン / 間接路 / 直接路 / 神経終末 / ドパミンβ水酸化酵素 / シナプスボタン / ドパミントランスポーター / ジストニア / パーキンソニズム / 脳・神経 / nuclear receptor / 発達 / 核内受容体 / catecholamine / 相同組み換え / タンパク質 / 生理学 / 蛋白質 / 医療・福祉 / 神経科学 / 臨床神経科学 / DNA組換え酵素 / アデノ随伴ウイルス / 芳香族アミノ線脱炭酸酵素 / 老化 / 酵素 / 神経細胞死 / 一酸化窒素合成酵素 / 分子生物学 / 高フェニルアラニン血症 / ドーパ反応性ジストニア / GTPシクロヒドロラーゼI / テトラヒドロビオプテリン … More Except Principal Investigator テトラヒドロビオプテリン / 一酸化窒素 / 敗血症 / 血管 / 持続勃起症 / 交感神経 / 高血圧 / L-DOPA / トランスジェニックマウス / cDNA / 芳香族モノアミン / 新生児外科疾患 / ビオプテリン代謝産物 / 壊死性腸炎 / BH2 / BH4 / セロトニン経路 / セロトニン合成経路 / キヌレニン経路 / トリプトファン / メラトニン / 敗血症関連脳症 / 不安定高血圧症 / Priapism （持続勃起症） / 持続勃起症（Priapism） / セピアプテリン還元酵素 / Priapism（持続勃起症） / 徐脈 / ノルアドレナリン / 一酸化窒素合成酵素 / プテリジン / 血管内皮細胞 / アスコルビン酸 / 敗血症性ショック / 眼白子症原因遺伝子 / Gタンパク質連関型受容体 / α1アドレナリン受容体 / 血管平滑筋 / 日内変動 / 血圧 / ドーパ / 生理活性物質 / ドパミン神経 / ドパミンニューロン / ドパミン / lymphocyte / Dopamine β-hydroxylase / Malignant hyperphenylalaninemia / 6-pyruvoyltetrahydropterin synthase / knockout mice / Tetrahydrobiopterin / 6-PTPS / リンパ球 / ドパミンβ-水酸化酵素 / 悪性高フェニルアラニン血症 / 6-ピルボイルテトラヒドロプテリン合成酵素 / ノックアウトマウス / Transgenic Mouse / Gene Targeting / Gene Expression / Phenylethanolamine N-Methyltransferase / Dopamine beta-Hydroxylase / Aromatic L-Amino Acid Decarboxylase / Tyrosine Hydroxylase / Catecholamine Neurons / フェニルエタノ-ルアミンNーメチル転移酵素 / ド-パミンβー水酸化酵素 / カテコ-ルアミン神経 / 分子生物学 / ドーパミンβー水酸化酵素 / ドーパミンbeta-水酸化酵素 / 遺伝子標的法 / 遺伝子発現 / フェニルエタノールアミンN-メチル転移酵素 / ドーパミンβ-水酸化酵素 / 芳香族アミノ酸脱炭酸酵素 / チロシン水酸化酵素 / カテコールアミン神経 / Transgenic mouse / Catecholamineーsynthesizing enzyme / DNA probe / human DOPA decarboxylase / human Phenyletanolamine N-metyltransferase / human Dopamine B-hydroxylase / human Tyrosinehydroxylase / トランスジェニックスマウス / カテコ-ルアミン生合成酵素 / DNAプロ-ブ / ヒト・ド-パ脱炭酸酵素 / ヒト・フェニルエタノ-ルアミンNーメチル基転移酵素 / ヒト・ド-パミンβー水酸化酵素 / ヒト・チロシン水酸化酵素 Less

テトラヒドロビオプテリン・サプライにより新生児壊死性腸炎の中枢機能予後を取戻す
- Principal Investigator
  
  杉田光士郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kagoshima University
Crosstalk Analysis of Melatonin and Tetrahydrobiopterin in Sepsis-Related Encephalopathy
- Principal Investigator
  
  Niiyama Shuhei
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Study of the dynamics of tetrahydrobiopterin in sepsis and the potentiality of BH4 as therapeutic target.
- Principal Investigator
  
  Yasuda Tomotsugu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
発達に伴うモノアミンニューロンの代謝シフト機構の解明Principal Investigator
- Principal Investigator
  
  一瀬宏
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.
- Principal Investigator
  
  SUMI-ICHINOSE Chiho
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
発達に伴う大脳基底核回路変遷におけるモノアミン入力の役割Principal Investigator
- Principal Investigator
  
  一瀬宏
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
Functional analysis of DOPAergic transmission in cardiovascular system
- Principal Investigator
  
  GOSHIMA Yoshio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.
- Principal Investigator
  
  Sumi-Ichinose Chiho
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Molecular mechanisms for the control of monoamine levels in the brain and the etiology of PTSD using serotonin-deficient mice.Principal Investigator
- Principal Investigator
  
  ICHINOSE Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Institute of Technology
モノアミン関連遺伝子の特異的破壊による脳高次機能調節および代償機構の解析Principal Investigator
- Principal Investigator
  
  一瀬宏
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
A new approach to various diseases based on abnormal metabolism of petering.
- Principal Investigator
  
  ICHINOSE Chino
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fujita Health University
カテコールアミン合成と老化・神経細胞死との関わりPrincipal Investigator
- Principal Investigator
  
  一瀬宏
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Fujita Health University
神経伝達物質の合成と老化・神経細胞死との関わりPrincipal Investigator
- Principal Investigator
  
  一瀬宏
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Fujita Health University
Alteration in neural function by an inducible knock-out of tyrosine hydroxylase.Principal Investigator
- Principal Investigator
  
  ICHINOSE Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Fujita Health University
Role of Neurotransmitters and orphan receptors in neural cytoarchitecture of the brain..Principal Investigator
- Principal Investigator
  
  ICHINOSE Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neuroscience in general
- Research Institution
  Fujita Health University
生体機能調節因子としてのテトラヒドロビオプテリンの分子生物学的研究Principal Investigator
- Principal Investigator
  
  一瀬宏
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Fujita Health University
Molecular Genetic Studies on the Structure, Function and Pathology of Catecholamine Neurons
- Principal Investigator
  
  NAGATSU Toshiharu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Fujita Health University
Gene Analysis Using cDNA Probes of Human CatecholamineーSynthesizing Enzymes in relation to Neuropsychiatric Diseases
- Principal Investigator
  
  NAGATSU Toshiharu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagoya University

[Journal Article] Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate.2024
- Author(s)
  Hara S, Kono H, Suto N, Kojima H, Kishimoto K, Yoshino H, Niiyama S, Kakihana Y, Ichinose H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 4;717 Pages: 150059-150059
- DOI
  10.1016/j.bbrc.2024.150059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291
[Journal Article] Comparison of the levels of neopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-22022
- Author(s)
  Satoshi Hara, Tama Sanatani, Natsu Tachikawa, Yukihiro Yoshimura, Nobuaki Miyata, Hiroaki Sasaki, Risa Kuroda, Chinatsu Kamikokuryo, Tomohiro Eguchi, Shuhei niiyama, Yasuyuki Kakihana, Hiroshi Ichinose
- Journal Title
  
  Heliyon
  
  Volume: - Issue: 5 Pages: e09371-e09371
- DOI
  10.1016/j.heliyon.2022.e09371
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291
[Journal Article] Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice2022
- Author(s)
  Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: - Pages: 929448-929448
- DOI
  10.3389/fphar.2022.929448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291, KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-19K09438
[Journal Article] Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP2019
- Author(s)
  Kurosaki Hiroki、Yamaguchi Kentaro、Man-yoshi Kohei、Muramatsu Shin-ichi、Hara Satoshi、Ichinose Hiroshi
- Journal Title
  
  Neurochemistry International
  
  Volume: 125 Pages: 16-24
- DOI
  10.1016/j.neuint.2019.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function2019
- Author(s)
  Miramontes-Gonzalez Jose Pablo、Hightower Makena、Kurosaki Hiroki、Schork Andrew J.、Biswas Nilima、Vaingankar Sucheta、Mahata Manjula、Lipkowitz Michael S.、Nievergelt Caroline M.、Baker Dewleen G.、Ziegler Michael G.、Leon-Jimenez David.、Gonzalez-Sarmiento Rogelio、Ichinose Hiroshi、O’Connor Daniel T.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5055-5055
- DOI
  10.1038/s41598-019-41504-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] Human tyrosine hydroxylase in Parkinson's disease and in related disorders.2019
- Author(s)
  Nagatsu T, Nakashima A, Ichinose H, Kobayashi K.
- Journal Title
  
  J Neural Transm (Vienna)
  
  Volume: 126(4) Issue: 4 Pages: 397-409
- DOI
  10.1007/s00702-018-1903-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11004, KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.2018
- Author(s)
  Ichinose H; Inoue K; Arakawa S; Watanabe Y; Kurosaki H; Koshiba S; Hustad E; Takada M; Aasly JO
- Journal Title
  
  J Neural Transm
  
  Volume: 125 Issue: 1 Pages: 45-52
- DOI
  10.1007/s00702-017-1784-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0193, KAKENHI-PROJECT-17K19454, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05879, KAKENHI-PUBLICLY-16H01611, KAKENHI-PUBLICLY-17H05565, KAKENHI-PUBLICLY-17H05567, KAKENHI-PUBLICLY-17H06030, KAKENHI-PROJECT-16H02454, KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity2018
- Author(s)
  Hara Satoshi、Fukumura Soichiro、Ichinose Hiroshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 4 Pages: 1420-1427
- DOI
  10.1074/jbc.ra118.005280
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function2018
- Author(s)
  Tel-Karthaus Nina、Kers-Rebel Esther D.、Looman Maaike W.、Ichinose Hiroshi、de Vries Carlie J.、Ansems Marleen
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1797-1797
- DOI
  10.3389/fimmu.2018.01797
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H06276
[Journal Article] Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia2017
- Author(s)
  Sumi-Ichinose Chiho、Suganuma Yui、Kano Taiki、Ihira Noriko、Nomura Hiroko、Ikemoto Kazuhisa、Hata Tadayoshi、Katoh Setsuko、Ichinose Hiroshi、Kondo Kazunao
- Journal Title
  
  Physiological Reports
  
  Volume: 5 Issue: 6
- DOI
  10.14814/phy2.13196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Journal Article] Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose and Kazunao Kondo
- Journal Title
  
  Physiological Reports
  
  Volume: 5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08561
[Journal Article] The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation2017
- Author(s)
  Rothe Tobias、Ipseiz Natacha、Faas Maria、Lang Stefanie、Perez-Branguli Francesc、Metzger Daniel、Ichinose Hiroshi、Winner Beate、Schett Georg、Kronke Gerhard
- Journal Title
  
  The Journal of Immunology
  
  Volume: 198 Issue: 10 Pages: 3878-3885
- DOI
  10.4049/jimmunol.1600638
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Journal Article] L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor2017
- Author(s)
  Masukawa Daiki、Koga Motokazu、Sezaki Anna、Nakao Yuka、Kamikubo Yuji、Hashimoto Tatsuo、Okuyama-Oki Yuki、Aladeokin Aderemi Caleb、Nakamura Fumio、Yokoyama Utako、Wakui Hiromichi、Ichinose Hiroshi、Sakurai Takashi、Umemura Satoshi、Tamura Koichi、Ishikawa Yoshihiro、Goshima Yoshio
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 18 Pages: 1-16
- DOI
  10.1172/jci.insight.90903
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07062, KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19403, KAKENHI-PROJECT-15H04687, KAKENHI-PROJECT-16H05358, KAKENHI-PROJECT-15K21273, KAKENHI-PROJECT-15H05761, KAKENHI-PUBLICLY-17H05555, KAKENHI-PROJECT-16H05300
[Journal Article] Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.2016
- Author(s)
  Ishikawa, T., Imamura, K., Kondo, T., Koshiba, Y., Hara, S., Ichinose, H., Furujo, M., Kinoshita, M., Oeda, T., Takahashi, J., Takahashi, R., and Inoue, H.
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 25 Pages: 5188-5197
- DOI
  10.1093/hmg/ddw339
- NAID
  120005941271
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Journal Article] Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice2016
- Author(s)
  Korner, G., Scherer, T., Adamsen, D., Rebuffat, A., Crabtree, M., Rassi, A., Scavelli, R., Homma, D., Ledermann, B., Konrad, D., Ichinose, H., Wolfrum, C., Horsch, M., Rathkolb, B., Klingenspor, M., Beckers, J., Wolf, E., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., Blau, N., Rozman, J., and Thony, B
- Journal Title
  
  J Inherit Metab Dis
  
  Volume: 39 Issue: 2 Pages: 309-319
- DOI
  10.1007/s10545-015-9909-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Journal Article] Dopamine or biopterin deficiency potentiates phosphorylation at Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.2015
- Author(s)
  Kawahata I, Ohtaku S, Tomioka Y, Ichinose H, Yamakuni T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 465 Issue: 1 Pages: 53-58
- DOI
  10.1016/j.bbrc.2015.07.125
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Journal Article] Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells2015
- Author(s)
  Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A
- Journal Title
  
  J Exp Med.
  
  Volume: 212 Issue: 10 Pages: 1623-1640
- DOI
  10.1084/jem.20142088
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PUBLICLY-15H01422, KAKENHI-PROJECT-14J07006, KAKENHI-PROJECT-26670470, KAKENHI-PROJECT-26870571, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305
[Journal Article] Redox sensor proteins for highly sensitive direct imaging of intracellular redox state.2015
- Author(s)
  Sugiura K, Nagai T, Nakano M, Ichinose H, Nakabayashi T, Ohta N, Hisabori T
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 457 Issue: 3 Pages: 242-248
- DOI
  10.1016/j.bbrc.2014.12.095
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Journal Article] Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.2014
- Author(s)
  Xu F, Sudo Y, Sanechika S, Yamashita J, Shimaguchi S, Honda S, Sumi-Ichinose C, Mori-Kojima M, Nakata R, Furuta T, Sakurai M, Sugimoto M, Soga T, Kondo K, Ichinose H.
- Journal Title
  
  FEBS Letters
  
  Volume: 588 Issue: 21 Pages: 3924-3931
- DOI
  10.1016/j.febslet.2014.09.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460346, KAKENHI-PROJECT-26462860
[Journal Article] Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients2013
- Author(s)
  Fukuda, S., Horiguchi, M., Yamaguti, K., Nakatomi, Y., Kuratsune, H., Ichinose, H., and Watanabe, Y.
- Journal Title
  
  Life Sciences
  
  Volume: 92 Issue: 3 Pages: 183-18
- DOI
  10.1016/j.lfs.2012.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.2013
- Author(s)
  Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
- Journal Title
  
  Nat Immunol.
  
  Volume: 14 Issue: 3 Pages: 230-237
- DOI
  10.1038/ni.2520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08459, KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23659242, KAKENHI-PROJECT-23790346, KAKENHI-PROJECT-23790545, KAKENHI-PROJECT-25670233
[Journal Article] The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain.2013
- Author(s)
  Homma, D., Katoh, S., Tokuoka, H. & Ichinose, H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: (in press) Issue: 1 Pages: 70-81
- DOI
  10.1111/jnc.12287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-24700317
[Journal Article] Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency2013
- Author(s)
  Lee, N.-C., Shieh, Y.-D., Chien, Y.-H., Tzen, K.-Y., Yu, I.-S., Chen, P.-W., Hu, M.-H., Hu, M., Muramatsu, S., Ichinose, H., et al.
- Journal Title
  
  Neurobiology of disease
  
  Volume: 52 Pages: 177-90
- DOI
  10.1016/j.nbd.2012.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-23590473, KAKENHI-PUBLICLY-25110729, KAKENHI-PUBLICLY-23110515
[Journal Article] Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy2012
- Author(s)
  Yagi, H., Sanechika, S., Ichinose, H., Sumi-Ichinose, C., Mizukami, H., Urabe, M., Ozawa, K., and Kume, A.
- Journal Title
  
  Neuroreport
  
  Volume: 23 Issue: 1 Pages: 30-34
- DOI
  10.1097/wnr.0b013e32834e3a87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247
[Journal Article] The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila2012
- Author(s)
  Kanao, T., Sawada, T., Davies, S.-A., Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N., and Imai, Y
- Journal Title
  
  PloS one
  
  Volume: 7 Issue: 2 Pages: 1-13
- DOI
  10.1371/journal.pone.0030958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PUBLICLY-23110502, KAKENHI-PROJECT-23790973, KAKENHI-PROJECT-23890206
[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain2011
- Author(s)
  Homma, D., Sumi-Ichinose, C., Tokuoka, H., Ikemoto, K., Nomura, T., Kondo, K., Katoh, S., and Ichinose, H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 2 Pages: 1445-1452
- DOI
  10.1074/jbc.m110.159426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T)2011
- Author(s)
  Koshiba, S., Tokuoka, H., Yokoyama, T., Horiuchi, E., Ichinose, H., andHasegawa, K.
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 118 Issue: 6 Pages: 899-903
- DOI
  10.1007/s00702-011-0587-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells2011
- Author(s)
  Sekiya, T., et al
- Journal Title
  
  Nature Communications
  
  Volume: 2 Issue: 1 Pages: 269-269
- DOI
  10.1038/ncomms1272
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059014, KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23790346, KAKENHI-PROJECT-23390123
[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection2011
- Author(s)
  Tokuoka, H., Muramatsu, S., Sumi- Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D., and Ichinose, H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 50 Pages: 43549-43558
- DOI
  10.1074/jbc.m111.284729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-21700347, KAKENHI-PROJECT-23590473
[Journal Article] Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals2010
- Author(s)
  Sumi-Ichinose, C., Ichinose, H., Ikemoto, K., Nomura, T., and Kondo, K.
- Journal Title
  
  Journal of Pharmacological Science
  
  Volume: 114 Pages: 17-24
- NAID
  10029889595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010
- Author(s)
  Sumi-Ichinose C, et al.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 114 Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] A case of late-onset Segawa syndrome(autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene2006
- Author(s)
  Furuya, H., Murai, H., Takasugi, K., Ohyagi, Y., Urano, F., Kishi, T., Ichinose, H., Kira, J.
- Journal Title
  
  CLINICAL NEUROLOGY AND NEUROSURGERY (in press)
- Data Source
  KAKENHI-PROJECT-17024017
[Journal Article] Viral-Mediated Temporally Controlled Dopamine Production in a Rat Model of Parkinson Disease2006
- Author(s)
  L, X.G., Okada, T., Kodera, M., Nara, Y., Takino, N., Muramatsu, C., Ikeguchi, K., Urano, F., Ichinose, H., Metzger, D., Chambon, P., Nakano, I., Ozawa, K., Muramatsu, S.
- Journal Title
  
  MOLECULAR THERAPY 13・1
  
  Pages: 160-166
- Data Source
  KAKENHI-PROJECT-17024017
[Journal Article] Molecular Mechanism for Pterin-Mediated Inactivation of Tyrosine Hydroxylase : Formation of Insoluble Aggregates of Tyrosine Hydroxylase2006
- Author(s)
  Urano, F., Hayashi, N, Arisaka, F., Kurita, H., Murata, S., Ichinose, H.
- Journal Title
  
  JOURNAL OF BIOCHEMISTRY 139(in press)
- NAID
  10018845291
- Data Source
  KAKENHI-PROJECT-17024017
[Journal Article] A new mutation (Thr106Ile) of the GTP cyclohydrolase 1 gene associated with DYT5 dystonia (Segawa disease)2005
- Author(s)
  Ohta, E., Toyoshima, I., Funayama, M., Ichinose, H., Hasegawa, K., Obata, F.
- Journal Title
  
  MOVEMENT DISORDERS 20
  
  Pages: 1083-1084
- Data Source
  KAKENHI-PROJECT-17024017
[Journal Article] Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities2005
- Author(s)
  Sumi-Ichinose, C., Urano, F., Shimomura, A., Sato, T., Ikemoto, K., Shiraishi, H., Senda, T., Ichinose, H., Nomura, T.
- Journal Title
  
  Journal of Neurochemistry 95
  
  Pages: 703-714
- Data Source
  KAKENHI-PROJECT-17024017
[Journal Article] Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD40:Relevance to Parkinson's disease2005
- Author(s)
  Okuno, T., Nakatsuji, Y., Kumanogoh, A., Moriya, M., Ichinose, H., Sumi, H., Fujimura, H., Kikutani, H., Sakoda, S.
- Journal Title
  
  JOURNAL OF NEUROSCIENCE RESEARCH 81
  
  Pages: 874-882
- Data Source
  KAKENHI-PROJECT-17024017
[Journal Article] Nerve growth factor-induced expression of the GTP cyclohydrolase I gene via Ras/MEK pathway in PC12D cells2005
- Author(s)
  Ito, T., Suzuki, T., Ichinose, H.
- Journal Title
  
  Journal of Neurochemistry 95
  
  Pages: 563-569
- Data Source
  KAKENHI-PROJECT-17024017
[Presentation] Sepiapterin reductase gene disrupted mice suffered from severe priapism.2019
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] キノノイドジヒドロプテリジン還元酵素の基質認識機構の解析2019
- Author(s)
  河野はるか, 古田忠臣, 原怜, 一瀬宏
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] 敗血症におけるプテリジン関連物質の動態とNOとの関連2019
- Author(s)
  政所祐太郎, 上國料千夏, 原怜, 一瀬宏, 安田智嗣
- Organizer
  日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-18K08894
[Presentation] キノノイドジヒドロプテリジン還元酵素のリガンド認識機構のin silico解析2018
- Author(s)
  河野はるか, 古田忠臣, 原怜, 一瀬宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] 野生型THおよびS40E変異型THの過剰発現による線条体ドーパミン量の変化2018
- Author(s)
  岩下由佳, 宗実悠佳, 原怜, 村松慎一, 一瀬宏
- Organizer
  第33回日本大脳基底核研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] アスコルビン酸生合成遺伝子欠損ラット（ODSラット）におけるプテリジン代謝の変化2018
- Author(s)
  竹下直輝, 川出野絵, 鈴木若菜, 原怜, 堀尾文彦, 一瀬宏
- Organizer
  第32回日本プテリジン研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] ビタミンC欠乏ODSラット脳におけるビオプテリン代謝の変化2018
- Author(s)
  竹下直輝, 川出野絵, 鈴木若菜, 原怜, 堀尾文彦, 一瀬宏
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] システイン残基修飾によるビオプテリン生合成酵素の可逆的活性制御機構の解析2018
- Author(s)
  一瀬宏, 福村宗一郎, 原怜
- Organizer
  第454回ビタミンB研究協議会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] Effect of methotrexate on pteridine-contents and relaxation response of the aorta from quinonoid-dihydropteridine reductase (QDPR) knockout mice.2018
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Ichinose Hiroshi, and Kazunao Kondo
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] MPTPによるin vivoドーパミン生合成の低下はビオプテリン添加により回復する2018
- Author(s)
  一瀬宏, 黒崎宏貴, 山口健太郎, 萬好晃平, 原怜
- Organizer
  第22回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] キノノイドジヒドロプテリジン還元酵素の中枢および末梢組織での分布とノックアウトマウスにおけるモノアミン量の変化2018
- Author(s)
  宮嶋克也, 実近翔, 山下純平, 須藤雄介, 原慶賢, 堀口美恵子, 井上謙一, 高田昌彦, 原怜, 一瀬宏
- Organizer
  第32回日本プテリジン研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] テトラヒドロビオプテリン欠損マウスは、重篤な持続勃起症を発症する2018
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、近藤一直
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Brain aging and alteration of biopterin metabolism in Parkinson’s disease2018
- Author(s)
  Ichinose H, Arakawa S, Watanabe Y, Kurosaki H, Aasly JO
- Organizer
  The 61st Annual Meeting of the Japanese Society for Neurochemistry
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] 蛍光標識を用いたドーパミン結合に応答するチロシン水酸化酵素の構造変化の解析2018
- Author(s)
  犬飼駿弥, 原怜, 一瀬宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] Biopterin-recycling enzyme, quinonoid dihydropteridine reductase, is expressed in oligodendrocyte, but undetectable in monoaminergic neurons.2017
- Author(s)
  Katsuya Miyajima, Sho Sanechika, Yoshitaka Hara, Ken-ichi Inoue, Masahiko Takada, Satoshi Hara, Hiroshi Ichinose
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] メトトレキサート投与が、キノノイド型ジヒドロビオプテリン還元酵素遺伝子ノックアウトマウス大動脈のプテリジン含量と弛緩反応に及ぼす影響2017
- Author(s)
  一瀬（鷲見）千穂, 菅沼由唯, 狩野泰輝, 井平典子, 池本和久, 一瀬宏, 近藤一直
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] ラット腎由来線維芽細胞NRKにおけるBH4取込み機構の解析2017
- Author(s)
  國宗みなと, 山口健太郎, 原怜, 一瀬宏
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] Sepiapterin reductase gene disrupted mice suffered from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール(長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] ピルボイルテトラヒドロプテリン合成酵素のレドックス制御機構の解析2017
- Author(s)
  原怜, 安岡達矢, 一瀬宏
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] 黒質線条体系ドーパミンニューロンの制御機構と病態2017
- Author(s)
  一瀬宏
- Organizer
  第28回マイクロダイアリシス研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] ビオプテリン合成反応を触媒するアルド・ケト還元酵素の探索2017
- Author(s)
  奥津歓、原怜、一瀬宏
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] Sepiapterin reductase gene disrupted mice suffered from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose, Kazunao Kondo
- Organizer
  第90回日本薬理学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] A story of identification of the causative gene for Segawa’s disease.2017
- Author(s)
  Hiroshi Ichinose
- Organizer
  14th Asian and Oceanian Congress of Child Neurology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] パーキンソン病患者脳脊髄液におけるプテリジン化合物の変化について2017
- Author(s)
  一瀬宏
- Organizer
  第449回ビタミンB研究協議会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの血圧変動の機序2017
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] 発達に伴う脳内ドーパミン代謝の変化2017
- Author(s)
  萬好晃平, 服部弘毅, 黒田はる香, 村松慎一, 原怜, 一瀬宏
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの血圧変動の機序2017
- Author(s)
  一瀬（鷲見）千穂, 菅沼由唯, 狩野泰輝, 井平典子, 野村裕子, 池本和久, 畑忠善, 加藤節子, 一瀬宏, 近藤一直
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] エダアシクラゲのドーパミン合成系の遺伝的・生化学的解析2017
- Author(s)
  鈴木美奈子, 原怜, 一瀬宏, 梶谷嶺, 伊藤武彦, 立花和則
- Organizer
  日本動物学会関東支部第69回大会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] メトトレキサート投与が、キノノイド型ジヒドロビオプテリン還元酵素遺伝子ノックアウトマウス大動脈のプテリジン含量と弛緩反応におよぼす影響2017
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Development of molecular tools for in vivo quantification of synaptic boutons.2017
- Author(s)
  Satoshi Hara, Kousuke Horigome, Katsuya Miyajima, Hiroshi Ichinose
- Organizer
  International Syposium on Adaptive Circuit Shift 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] アミノ酸代謝におけるビオプテリンの生理的重要性について2017
- Author(s)
  一瀬宏
- Organizer
  日本ビタミン学会第69回大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] ビオプテリン欠損Spr-KOマウスにおけるパーキンソニズムと電気生理学的解析について2017
- Author(s)
  一瀬宏, 久保田光, 本間大悟
- Organizer
  第４回乳幼児のアミン系神経を考える研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] ピルボイルテトラヒドロプテリン合成酵素の可逆的な酸化還元制御の解析2017
- Author(s)
  福村宗一郎, 原怜, 安岡達矢, 一瀬宏
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] キノノイド型ジヒドロビオプテリン還元酵素遺伝子ノックアウトマウスの血小板凝集能2017
- Author(s)
  近藤一直, 菅沼由唯, 一瀬（鷲見）千穂, 狩野泰輝, 池本和久, 一瀬宏
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PUBLICLY-17H05555
[Presentation] ドーパミンおよびテトラヒドロビオプテリン生合成酵素の脳内過剰発現によるドーパミン調節機構の解析2016
- Author(s)
  一瀬宏、服部弘毅、黒田はる香、加藤北都、岩下由佳、徳岡宏文、原怜、村松慎一
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの加齢と循環器系フェノタイプの変化2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計記念館(京都府・京都市）
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] ビオプテリン欠損がひきおこす不安定な高血圧・徐脈とPriapism（持続勃起症）2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松交流センター(静岡県・浜松市)
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] チロシン水酸化酵素の過剰発現によるドーパミンニューロンへの影響2016
- Author(s)
  加藤北都、岩下由佳、徳岡宏文、原怜、村松慎一、一瀬宏
- Organizer
  第20回活性アミンに関するワークショップ
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] ピルボイルテトラヒドロプテリン合成酵素の酸化還元制御機構の解明2016
- Author(s)
  原怜、安岡達也、一瀬宏
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスは変動の大きい高血圧、徐脈とpriapism（持続勃起症）を生じる2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第30回日本プテリジン研究会
- Place of Presentation
  名古屋大学環境学研究科環境総合館レクチャーホール１Ｆ(愛知県・名古屋市）
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Sepiapterin reductase knockout mice suffered from unstable hypertension and serious priapism.2016
- Author(s)
  ①Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, and Kazunao Kondo.
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] ビオプテリン欠乏によるチロシン水酸化酵素タンパク質調節機構の解析2016
- Author(s)
  一瀬宏
- Organizer
  第445回ビタミンB研究協議会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] Regulation of the protein levels of tyrosine hydroxylase by tetrahydrobiopterin in the brain.2016
- Author(s)
  Hiroshi Ichinose
- Organizer
  Satelite Symposium of Neuroscience 2016 （大脳基底核の機能と疾患：基礎と臨床）
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] The monoamine neurons - its physiological role and related neuropsychological diseases.2016
- Author(s)
  Hiroshi Ichinose
- Organizer
  Neuroscience 2016 (The 39th Annual Meeting of the Japan Neuroscience Society)
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] ピルボイルテトラヒドロプテリン合成酵素は酸化的修飾によって活性を制御されるタンパク質である2016
- Author(s)
  原怜、安岡達也、一瀬宏
- Organizer
  第30回日本プテリジン研究会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] キノノイド型ジヒドロプテリン還元酵素遺伝子ノックアウトマウス大動脈リング標本の血管弛緩反応2015
- Author(s)
  ③一瀬―鷲見千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  多摩　日本医科大学多摩永山病院会議室
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] セピアプテリン還元酵素を欠損したドパ反応性ジストニアモデルマウスにおける大脳基底核の異常な活動2015
- Author(s)
  久保田光、知見聡美、本間大悟、高草木薫、一瀬宏、南部篤
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] 芳香族L-アミノ酸段炭酸酵素欠損症モデルマウスにおけるドーパミン代謝変化の解析2015
- Author(s)
  黒田はる香、Lee NC, Chen WL, 一瀬宏
- Organizer
  第88回日本生化学会大会（BMB2015)
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] Hypoxiaが血管内皮細胞における細胞内テトラヒドロビオプテリン量と細胞増殖に及ぼす影響2015
- Author(s)
  ②池本和久、菅沼由唯、狩野泰輝、野村隆英、一瀬千穂、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  多摩　日本医科大学多摩永山病院会議室
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] パーキンソン病発症神経毒MPTPの神経変性作用に対するテトラヒドロビオプテリンの効果2015
- Author(s)
  山口健太郎、黒崎宏貴、村松慎一、一瀬宏
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良市
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] テトラヒドロビオプテリン生合成酵素の過剰発現による脳内モノアミン量の変化の解析2015
- Author(s)
  服部弘毅、村松慎一、一瀬宏
- Organizer
  第88回日本生化学会大会（BMB2015)
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] Molecular mechanism of monoamine deficiency in the mouse lacking an enzyme for recycling of tetrahydrobiopterin.2015
- Author(s)
  Ichinose H, Xu Feng, Sudo Y, Sanechika S, Hara Y
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  さいたま市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] キノノイド型ジヒドロビオプテリン還元酵素遺伝子ノックアウトマウス大動脈リング標本の血管弛緩反応2015
- Author(s)
  一瀬-鷲見千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬宏、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  東京
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PUBLICLY-15H01422
[Presentation] モノアミン・ビオプテリン代謝改変マウスを用いたモノアミンニューロンの制御機構と発達変化の解析2011
- Author(s)
  一瀬宏
- Organizer
  第64回日本自律神経学会総会
- Place of Presentation
  秋田市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] Tetrahydrobiopterin: As a regulator of monoamine signals in the brain2011
- Author(s)
  Hiroshi Ichinose
- Organizer
  The 6_th International Conference of Neurons and Brain Diseases
- Place of Presentation
  富山市
- Year and Date
  2011-08-04
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] Difference in biopterin metabolism between patients with PARK8 (I2020T) and those with sporadic Parkinson's disease.2011
- Author(s)
  Hiroshi Ichinose et al.
- Organizer
  Genomic Epidemiology of Parkinson's Disease (GEO-PD) 2011
- Place of Presentation
  Illinois, USA
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] 家族性パーキンソン病PARK8患者の脳脊髄液中ビオプテリン代謝の解析2011
- Author(s)
  一瀬宏他
- Organizer
  第9回神経科学研究会
- Place of Presentation
  東京
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] ビオプテリンとドーパミン-線条体におけるドーパミンシグナルの調節機構2010
- Author(s)
  一瀬宏
- Organizer
  第25回日本大脳基底核研究会
- Place of Presentation
  福島県福島市
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] ビオプテリンとドーパミン-線条体におけるドーパミンシグナルの調節機構2010
- Author(s)
  一瀬宏
- Organizer
  第25回大脳基底核研究会
- Place of Presentation
  福島市
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] チロシン水酸化酵素(TH)タンパク質量変化によるドパミン生合成量の調節2009
- Author(s)
  一瀬宏
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] Difference in biopterin metabolism between patients with PARK8 (I2020T) and those with sporadic Parkinson’s disease.
- Author(s)
  Hiroshi Ichinose et al.
- Organizer
  Genomic Epidemiology of Parkinson’s Disease (GEO-PD) 2011
- Place of Presentation
  Illinois (USA)
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] 家族性パーキンソン病PARK8患者の脳脊髄液中ビオプテリン代謝の解析
- Author(s)
  一瀬宏
- Organizer
  第9回神経科学研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] Tetrahydrobiopterin: As a regulator of monoamine signals in the brain.
- Author(s)
  Hiroshi Ichinose
- Organizer
  The 6th International Conference of Neurons and Brain Diseases.
- Place of Presentation
  Toyama (Japan)
- Data Source
  KAKENHI-PROJECT-21500305
[Presentation] Aortic relaxation by acethlcholine is maintained against hyper dihydrobiopterinemia in quinonoid-dihydrobiopterin reductase knockout mice
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Takahide Nomura, and Kazunao Kondo
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  Naggoya, Japan
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460346
[]

1. ICHINOSE Chiho (10247653)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. OHYE Tamae (10247661)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SUZUKI Takahiro (70298545)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. NAGATSU Toshiharu (40064802)

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# of Collaborated Products: 0 results
5. 上國料千夏 (50751278)

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6. INAGAKI Hidehito (70308849)

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7. Kondo Kazunao (90270983)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
8. Niiyama Shuhei (40258455)

# of Collaborated Projects: 2 results

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9. 萩原昌子 (00231514)

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10. 政所祐太郎 (40794061)

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11. Ihira Noriko

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12. HIROFUMI Tokuoka (10452020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. KANEDA Norio (00144139)

# of Collaborated Projects: 1 results

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14. NAOI Makoto (50022786)

# of Collaborated Projects: 1 results

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15. KOBAYASHI Kazuto (90211903)

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16. IKEMOTO Kazuhisa (40351019)

# of Collaborated Projects: 1 results

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17. SHIRAISHI Hiroaki (80319285)

# of Collaborated Projects: 1 results

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18. NOMURA Takahide (20156227)

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19. GOSHIMA Yoshio (00153750)

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# of Collaborated Products: 1 results
20. FUKAZAWA Yugo (60343745)

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21. Yasuda Tomotsugu (80437954)

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22. 小島雅代 (10340267)

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24. 中村史雄 (10262023)

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26. 及川雅人 (70273571)

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27. 伊藤隆史 (20381171)

# of Collaborated Projects: 1 results

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28. 外角直樹 (60368884)

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33. 矢野圭輔 (30757919)

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34. 加治建 (50315420)

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35. 武藤充 (70404522)

# of Collaborated Projects: 1 results

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36. INOUE Ken-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. NAKASHIMA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 七田崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ichinose Hiroshi 一瀬 宏

ICHINOSE Hiroshi 一瀬 宏

一瀬 宏 イチノセ ヒロシ

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発達に伴うモノアミンニューロンの代謝シフト機構の解明Principal Investigator

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発達に伴う大脳基底核回路変遷におけるモノアミン入力の役割Principal Investigator

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Molecular mechanisms for the control of monoamine levels in the brain and the etiology of PTSD using serotonin-deficient mice.Principal Investigator

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モノアミン関連遺伝子の特異的破壊による脳高次機能調節および代償機構の解析Principal Investigator

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カテコールアミン合成と老化・神経細胞死との関わりPrincipal Investigator

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神経伝達物質の合成と老化・神経細胞死との関わりPrincipal Investigator

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Alteration in neural function by an inducible knock-out of tyrosine hydroxylase.Principal Investigator

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Ichinose Hiroshi 一瀬宏

ICHINOSE Hiroshi 一瀬宏

一瀬宏イチノセヒロシ