Takagi Junichi 高木淳一

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TAKAGI Junichi 高木淳一

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Researcher Number	90212000
Other IDs
External Links
Affiliation (Current)	2025: 大阪大学, 蛋白質研究所, 教授
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 蛋白質研究所, 教授 2018 – 2022: 大阪大学, 蛋白質研究所, 教授 2012 – 2017: 大阪大学, たんぱく質研究所, 教授 2003 – 2012: 大阪大学, 蛋白質研究所, 教授 2007: 京都大学, 大阪大学・蛋白質研究所, 教授 1998: 東工大, 生命理工学部, 助手 1991 – 1998: 東京工業大学, 生命理工学部, 助手
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Structural biochemistry / Biological Sciences / Cell biology / Chemical biology / Biological Sciences / Complex systems / Hematology / General medical chemistry / Structural biochemistry … More Except Principal Investigator … More Functional biochemistry / Biomedical engineering/Biological material science / General medical chemistry / Structural biochemistry / 医学一般 / Biological Sciences / Nanomaterials/Nanobioscience / Biological Sciences Less
Keywords	Principal Investigator X線結晶構造解析 / 受容体 / インテグリン / 環状ペプチド / 電子顕微鏡イメージング / LRP6 / 構造生物学 / シグナル伝達 / 立体構造解析 / 遺伝子治療 … More / ターゲッティング / アデノ随伴ウイルス / Wntシグナル / ケミカルバイオロジー / セマフォリン / reelin / リーリン / 電子顕微鏡 / X線結晶解析 / 血小板 / 細胞接着 / アラキドン酸代謝 / 繊維芽細胞 / 12-hydroxyeicosatetraenoic acid / アデニレートシクラーゼ / cAMP / 細胞外マトリックス / アゴニスト / Fc蛋白質 / 受容体シグナリング / アンタゴニスト / 遺伝子導入 / ペプチドタグ / 蛋白質ー脂質間相互作用 / 蛋白質間相互作用 / Ｘ線結晶構造解析 / brain development / electron microscopy / X-ray crystallography / ligand / receptor / sionalino molecules / LDLレセプター / LPR6 / 神経発生 / リガンド / 形態形成因子 / ニカストリン / Wntシグナル伝達系 / プレキシン / cutinase / 化合物スクリーニング / 免疫-神経インターフェイス / LR11 / リポタンパク質 / エンドサイトーシス / リポ蛋白質受容体 / クライオ電子顕微鏡 / ニューロリギン / ニューレキシン / シナプス / 過渡的複合体 / シグナル分子 / 基底膜 / リガンド複合体 / 構造解析 / 神経変性 / アルツハイマー病 / アミロイド / 細胞膜 / 血栓症 / システインスキャンニング / 膜貫通ヘリックス / コンフォーメーション変化 / エピトープ / モノクローナル抗体 / 創傷治癒 / 血液凝固XIII因子 / トランスグルタミナーゼ / トロンボスポンジン / 翻訳後修飾 / チロシン / 蛋白質硫酸化 … More Except Principal Investigator integrin / cell adhesion / VLA-4 / インテグリン / 細胞接着 / laminin / propolypeptide / von Willebrand factor / 血小板凝集 / ラミニン / プロポリペプチド / フォンビルブランド因子 / tetraspanin / cell / signal transduction / basement membrane / extracellular matrix / チロシンリン酸化 / フィロポディア / FRET / siRNA / 単クローン抗体 / 膜4回貫通蛋白質 / テトラスパニン / 細胞 / シグナル伝達 / 基底膜 / 細胞外マトリックス / Glue / Evolution / Gene conversion / Green fluorescent protein / Cementoin / Trappin / Transglutaminase / Crosslinking / WAP / インサイチュハイブリダイゼーション / インヒビター / エラフィン / 二次構造 / ランダムコイル / 遺伝子 / アルツハイマー病 / プロテアーゼインヒビター / トランスグルタミナーゼ / GFP / トラッピン / セメントイン / タンパク質の糊付け / cloning / monoclonal antibody / thrombin / Factor V / Factor X / blood coagulation / platelet aggregation / tumor cells / 分化誘導 / EPR-1 / 組織因子 / サブトラクションクローニング / モノクロナール抗体 / 血小板凝固 / モノクローナル抗体 / クローニング / モノクロナル抗体 / トロンビン / 血液凝固第V因子 / 血液凝固第X因子 / 血液凝固 / 腫瘍細胞 / melanoma / プロペプチド / α4β1 / フォンビルブラント因子 / メラノーマ / thrombospondin / blood coagulation factor XIIIa / collagen / リシルエンドペプチダ-ゼ / 単クロ-ン抗体 / コラ-ゲン / デカペプチド / Fc受容体 / ホスホリパーゼA_2 / トロンボスポンジン / トロンボスポンディン / 血液凝固第XIII因子 / コラーゲン / 免疫空間 / リンパ器官 / 免疫の場 / ストローマ細胞 / 免疫学 / クライオ電子顕微鏡 / 相関顕微鏡 / 電子顕微鏡 / CEMOVIS / 相関顕微鏡法 / 電子線トモグラフィー / 発生 / ニッチ / 蛋白修飾酵素 / マトリックス / サイトカイン Less

Creation of bivalent Fc protein that can control receptor signaling and elucidation of its structural mechanismPrincipal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
Structural elucidation of Wnt signaling mechanism using unique chemical toolsPrincipal Investigator
- Principal Investigator
  
  Takagi Junichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
Novel design of AAV capsid by LassoGraft TechnologyPrincipal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
Re-engineering of AAV particle by "peptide insertion" methodPrincipal Investigator
- Principal Investigator
  
  Takagi Junichi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
Structural mechanism of the Wnt-receptor interactionPrincipal Investigator
- Principal Investigator
  
  Takagi Junichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Analysis and Synthesis of Multidimensional Immune Organ Network
- Principal Investigator
  
  TAKAHAMA Yousuke
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Structural basis for the cell-cell communication at the neuro-immune interfacePrincipal Investigator
- Principal Investigator
  
  TAKAGI JUNICHI
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of a novel screening system for PPI-targeted drugs using cutinase fusion strategyPrincipal Investigator
- Principal Investigator
  
  TAKAGI Junichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
神経シナプスにおける接着複合体の準安定な二次元クラスター形成Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
Structural basis for cell signaling mediated by lipoprotein receptorsPrincipal Investigator
- Principal Investigator
  
  TAKAGI Junichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Development of vitreous ice technique and correlative microscopy to observe biological specimens at a molecular resolution
- Principal Investigator
  
  IWASAKI Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Osaka University
アミロイド前駆体蛋白質細胞外ドメインとその機能修飾因子の複合体の構造解析Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Dynamics of extracellular environments
- Principal Investigator
  
  NAGASAWA Takashi
- Project Period (FY)
  2005 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Structural analyses of the interaction between extracellular ligands and their receptorsPrincipal Investigator
- Principal Investigator
  
  TAKAGI Junichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
インテグリンレセプターにおける細胞膜をはさんだ双方向性シグナル伝達機構Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Structzal analysis of receptor-ligand interactions in cell signalingPrincipal Investigator
- Principal Investigator
  
  TAKAGI Junichi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Regulatory mechanisms of ligand binding and signaling events of laminin-binding integrins
- Principal Investigator
  
  SEKIGUCHI Kiyotoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
血小板活性化におけるβ1インテグリン（GPIIa）のシグナリング分子としての挙動Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Institute of Technology
創傷治癒過程における細胞-マトリックス接着因子としての血液凝固XIII因子の役割Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Institute of Technology
Cloning of Platelet aggregation factors from tumor cells
- Principal Investigator
  
  SAITO Yuji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
Development of protein crosslinking technology using the newly found family transglutaminase substrates termed cementoin
- Principal Investigator
  
  SUZUKI Yoko, 広瀬茂久
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
動物細胞におけるアゴニスト依存性cAMP排出の重要性とその機構の解明Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Institute of Technology
高等生物におけるcAMPの細胞外メッセンジャーとしての役割の解明Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Institute of Technology
Structure-function Studies On A Cancer Cell-specific Cell Adhesion Protein
- Principal Investigator
  
  SAITO Yuji
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology
蛋白質中の硫酸化チロシン残基の蛋白質-蛋白質相互作用における役割Principal Investigator
- Principal Investigator
  
  高木淳一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology
Analysis of functional domains within adhesive proteins with the aim of controlling the interaction between cells and collagens
- Principal Investigator
  
  SAITO Yuji
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医学一般
- Research Institution
  Tokyo Institute of Technology

[Book] 動物細胞を用いる膜タンパク質生産2013
- Author(s)
  高木淳一
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24651260
[Book] 動物細胞を用いる膜タンパク質生産2013
- Author(s)
  高木　淳一
- Publisher
  「膜タンパク質構造研究」（岩田　想　編）化学同人
- Data Source
  KAKENHI-PROJECT-24651260
[Book] タンパク質実験ノート(下)(岡田雅人、三木裕明、宮崎香編)2011
- Author(s)
  寒川剛、高木淳一
- Total Pages
  221
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-22121513
[Book] タンパク質実験ノート(下)(岡田雅人、三木裕明、宮崎香編)2011
- Author(s)
  寒川剛、高木淳一
- Total Pages
  221
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22247010
[Book] タンパク質間相互作用の検出-表面プラズモン共鳴法、「タンパク質実験ノート(下)」(岡田雅人、三木裕明、宮崎香編)2011
- Author(s)
  寒川剛、高木淳一
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22247010
[Book] インテグリン、「ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術」(田畑泰彦編)2009
- Author(s)
  高木淳一
- Publisher
  ディカルドゥ
- Data Source
  KAKENHI-PROJECT-17082004
[Book] Reelin Glycoprotein, biology, structure and roles in health and disease2008
- Author(s)
  Takagi, J.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17082004
[Book] Reelin Glycoprotein, biology, structure and roles in health and disease2008
- Author(s)
  Takagi,Junichi.(分担)
- Total Pages
  444
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17082004
[Book] 再生医療のための細胞生物学(関口清俊編)2007
- Author(s)
  高木淳一
- Publisher
  コロナ社
- Data Source
  KAKENHI-PROJECT-17082004
[Book] ポストゲノム時代のタンパク質科学-構造・機能・ゲノミクス-2007
- Author(s)
  高木、淳一
- Total Pages
  328
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-16207006
[Book] ポストゲノム時代のタンパク質科学-構造・機能・ゲノミクスー2007
- Author(s)
  高木、淳一
- Total Pages
  328
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-17082004
[Book] ポストゲノム時代のタンパク質科学-構造・機能・ゲノミクス- (Arthur M. Lesk原著)2007
- Author(s)
  高木淳一
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-17082004
[Book] ポストゲノム時代のタンパク質科学-構造・機能・ゲノミクスー2007
- Author(s)
  高木、淳一
- Total Pages
  328
- Publisher
  化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Book] 再生医療のための細胞生物学(関口清俊編)2006
- Author(s)
  高木, 淳一(分担)
- Total Pages
  176
- Publisher
  コロナ社
- Data Source
  KAKENHI-PROJECT-17082004
[Book] 「再生医療のための細胞生物学」(関口清俊編)2006
- Author(s)
  高木、淳一(分担)
- Total Pages
  176
- Publisher
  コロナ社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Book] 再生医療のための細胞生物学(関口清俊編)2006
- Author(s)
  高木淳一(分担)
- Total Pages
  176
- Publisher
  コロナ社
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein2023
- Author(s)
  Kuhn Christopher Cyrus、Basnet Nirakar、Bodakuntla Satish、Alvarez-Brecht Pelayo、Nichols Scott、Martinez-Sanchez Antonio、Agostini Lorenzo、Soh Young-Min、Takagi Junichi、Biert?mpfel Christian、Mizuno Naoko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 620-620
- DOI
  10.1038/s41467-023-36279-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex2023
- Author(s)
  Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eedem FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K.
- Journal Title
  
  Science Immunology
  
  Volume: 8 Issue: 81
- DOI
  10.1126/sciimmunol.adc9324
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06955, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-23K21290, KAKENHI-PROJECT-23K27671
[Journal Article] Advances in tooth agenesis and tooth regeneration2023
- Author(s)
  Ravi V.、Murashima-Suginami A.、Kiso H.、Tokita Y.、Huang C.L.、Bessho K.、Takagi J.、Sugai M.、Tabata Y.、Takahashi K.
- Journal Title
  
  Regenerative Therapy
  
  Volume: 22 Pages: 160-168
- DOI
  10.1016/j.reth.2023.01.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-22K10185
[Journal Article] Wnt 2022 EMBO | the Company of Biologists workshop and Yamada conference2023
- Author(s)
  Kikuchi Akira、Takagi Junichi、Takada Shinji、Ishitani Tohru、Minami Yasuhiro
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 4 Pages: 249-257
- DOI
  10.1111/gtc.13014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-21H02498, KAKENHI-PLANNED-21H05287
[Journal Article] Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions2022
- Author(s)
  Sakai Katsuya、Sugano-Nakamura Nozomi、Mihara Emiko、Rojas-Chaverra Nichole Marcela、Watanabe Sayako、Sato Hiroki、Imamura Ryu、Voon Dominic Chih-Cheng、Sakai Itsuki、Yamasaki Chihiro、Tateno Chise、Shibata Mikihiro、Suga Hiroaki、Takagi Junichi、Matsumoto Kunio
- Journal Title
  
  Nature Biomedical Engineering
  
  Volume: 7 Issue: 2 Pages: 164-176
- DOI
  10.1038/s41551-022-00955-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-21K15482, KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-21H01771, KAKENHI-PROJECT-20K06553, KAKENHI-PUBLICLY-21H00247
[Journal Article] Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy2022
- Author(s)
  Qianli Zhang, Akitoshi Miyamoto, Shin Watanabe, Takao Arimori, Masanori Sakai, Madoka Tomisaki, Tai Kiuchi, Junichi Takagi, Naoki Watanabe
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 10 Pages: 100301-100301
- DOI
  10.1016/j.crmeth.2022.100301
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06168, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-22H00456, KAKENHI-PROJECT-23K21290
[Journal Article] De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function2022
- Author(s)
  Sugano-Nakamura Nozomi、Matoba Kyoko、Hirose Mika、Bashiruddin Nasir K.、Matsunaga Yukiko、Yamashita Keitaro、Hirata Kunio、Yamamoto Masaki、Arimori Takao、Suga Hiroaki、Takagi Junichi
- Journal Title
  
  Structure
  
  Volume: 30 Issue: 10 Pages: 1411-1423.e4
- DOI
  10.1016/j.str.2022.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-23K21290
[Journal Article] Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D2022
- Author(s)
  Tanaka Tsubasa、Ekimoto Toru、Nagatomo Meri、Neyazaki Makiko、Shimoji Erena、Yamane Tsutomu、Kanagawa Sakura、Oi Rika、Mihara Emiko、Takagi Junichi、Akashi Satoko、Ikeguchi Mitsunori、Nogi Terukazu
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 11
- DOI
  10.1002/pro.4452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19236, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-19H03170, KAKENHI-PLANNED-18H05426, KAKENHI-PLANNED-19H05774, KAKENHI-PROJECT-23K23825
[Journal Article] Engineering ACE2 decoy receptors to combat viral escapability2022
- Author(s)
  Arimori Takao、Ikemura Nariko、Okamoto Toru、Takagi Junichi、Standley Daron M.、Hoshino Atsushi
- Journal Title
  
  Trends in Pharmacological Sciences
  
  Volume: 43 Issue: 10 Pages: 838-851
- DOI
  10.1016/j.tips.2022.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor?induced bullous pemphigoid2022
- Author(s)
  Yamashita Chigusa、Arase Noriko、Higuchi Shuhei、Arase Hisashi、Takagi Junichi、Nojima Satoshi、Tanemura Atsushi、Fujimoto Manabu
- Journal Title
  
  JAAD Case Reports
  
  Volume: 20 Pages: 65-68
- DOI
  10.1016/j.jdcr.2021.12.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18K08296, KAKENHI-PROJECT-21K08344
[Journal Article] ラッソ・グラフト法を用いた抗体の高付加価値化技術2022
- Author(s)
  高木淳一、菅　裕明
- Journal Title
  
  実験医学
  
  Volume: 40 Pages: 820-824
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ32022
- Author(s)
  Sen Soumyo、Spasic Aleksandar、Sinha Anjana、Wang Jialing、Bush Martin、Li Jihong、Ne?i? Dragana、Zhou Yuchen、Angiulli Gabriella、Morgan Paul、Salas-Estrada Leslie、Takagi Junichi、Walz Thomas、Coller Barry S.、Filizola Marta
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 62 Issue: 22 Pages: 5607-5621
- DOI
  10.1021/acs.jcim.2c00999
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Functional role of the Frizzled linker domain in the Wnt signaling pathway2022
- Author(s)
  Ko Seung-Bum、Mihara Emiko、Park Yedarm、Roh Kyeonghwan、Kang Chanhee、Takagi Junichi、Bang Injin、Choi Hee-Jung
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 421-421
- DOI
  10.1038/s42003-022-03370-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo2022
- Author(s)
  Ikemura Nariko、Taminishi Shunta、Inaba Tohru、Arimori Takao、Motooka Daisuke、Katoh Kazutaka、Kirita Yuhei、Higuchi Yusuke、Li Songling、Suzuki Tatsuya、Itoh Yumi、Ozaki Yuki、Nakamura Shota、Matoba Satoaki、Standley Daron M.、Okamoto Toru、Takagi Junichi、Hoshino Atsushi
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 650
- DOI
  10.1126/scitranslmed.abn7737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06767, KAKENHI-PROJECT-20H00455
[Journal Article] 環状ペプチドとタンパク質の融合による新しいバイオ医薬品モダリティの創成2021
- Author(s)
  菅野(中村) 希、高木淳一
- Journal Title
  
  Farumashia
  
  Volume: 57 Issue: 9 Pages: 820-824
- DOI
  10.14894/faruawpsj.57.9_820
- NAID
  130008082215
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-22021
- Author(s)
  Higuchi Yusuke、Suzuki Tatsuya、Arimori Takao、Ikemura Nariko、Mihara Emiko、Kirita Yuhei、Ohgitani Eriko、Mazda Osam、Motooka Daisuke、Nakamura Shota、Sakai Yusuke、Itoh Yumi、Sugihara Fuminori、Matsuura Yoshiharu、Matoba Satoaki、Okamoto Toru、Takagi Junichi、Hoshino Atsushi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3802-3802
- DOI
  10.1038/s41467-021-24013-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Structural mechanism of laminin recognition by integrin2021
- Author(s)
  Arimori Takao、Miyazaki Naoyuki、Mihara Emiko、Takizawa Mamoru、Taniguchi Yukimasa、Caba?as Carlos、Sekiguchi Kiyotoshi、Takagi Junichi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4012-4012
- DOI
  10.1038/s41467-021-24184-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins2021
- Author(s)
  Mihara E, Watanabe S, Bashiruddin N, Nakamura N, Matoba K, Maini R, Yin Y, Sakai K, Arimori T, Matsumoto K, Suga H, and Takagi J.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1543-1543
- DOI
  10.1038/s41467-021-21875-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-20K06553, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-20K20581
[Journal Article] Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling2021
- Author(s)
  Murashima-Suginami A.、Kiso H.、Tokita Y.、Mihara E.、Nambu Y.、Uozumi R.、Tabata Y.、Bessho K.、Takagi J.、Sugai M.、Takahashi K.
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 7
- DOI
  10.1126/sciadv.abf1798
- NAID
  120006958083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07347, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18K19423, KAKENHI-PROJECT-20K20581
[Journal Article] Structural insights into integrin α5β1 opening by fibronectin ligand2021
- Author(s)
  Schumacher Stephanie、Dedden Dirk、Nunez Roberto Vazquez、Matoba Kyoko、Takagi Junichi、Biert?mpfel Christian、Mizuno Naoko
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 19
- DOI
  10.1126/sciadv.abe9716
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems2021
- Author(s)
  Sato Nobuhiro、Yogo Rina、Yanaka Saeko、Martel Anne、Porcar Lionel、Morishima Ken、Inoue Rintaro、Tominaga Taiki、Arimori Takao、Takagi Junichi、Sugiyama Masaaki、Kato Koichi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 0 Issue: 6 Pages: 1-8
- DOI
  10.1093/jb/mvab012
- NAID
  40022687772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15981, KAKENHI-PROJECT-19KK0071, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-19H01017, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-19J15602, KAKENHI-PROJECT-17K07816, KAKENHI-PROJECT-19K16088, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20K20581
[Journal Article] De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist2021
- Author(s)
  Komatsu Yamato、Terasaka Naohiro、Sakai Katsuya、Mihara Emiko、Wakabayashi Risa、Matsumoto Kunio、Hilvert Donald、Takagi Junichi、Suga Hiroaki
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 11 Pages: 103302-103302
- DOI
  10.1016/j.isci.2021.103302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-20K06553, KAKENHI-PROJECT-21K18250
[Journal Article] Structural insights into the integrin α5β1 opening by fibronectin ligand.2021
- Author(s)
  Schumacher S, Dedden D, Nunez RV, Matoba K, Takagi J, Biertumpfel C, Mizuno N.
- Journal Title
  
  Science Advances
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Journal Article] tructural insights into the integrin α5β1 opening by fibronectin ligand.2021
- Author(s)
  Schumacher S, Dedden D, Nunez RV, Matoba K, Takagi J, Biertumpfel C, Mizuno N.
- Journal Title
  
  Science Advances
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20581
[Journal Article] Dissection of α 4 β 7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β 7 antibodies.2020
- Author(s)
  Sato T, Ishihara S, Marui R, Takagi J, Katagiri K
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 13221-13221
- DOI
  10.1038/s41598-020-70111-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-20K16290, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-20K20581
[Journal Article] Macrocyclic peptides that inhibit Wnt signallingviainteraction with Wnt3a2020
- Author(s)
  Otero-Ramirez Manuel E.、Matoba Kyoko、Mihara Emiko、Passioura Toby、Takagi Junichi、Suga Hiroaki
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 1 Issue: 1 Pages: 26-34
- DOI
  10.1039/d0cb00016g
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-20K20581
[Journal Article] High affinity modified ACE2 receptors protect from SARS-CoV-2 infection.2020
- Author(s)
  Higuchi Y, Suzuki T, Arimori T, Ikemura N, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Matsuura Y, Matoba S, Okamoto T, Takagi J, and Hoshino A.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.09.16.299891
- Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-20K20581
[Journal Article] Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding.2020
- Author(s)
  Iwagishi R, Tanaka R, Seto M, Takagi T, Norioka N, Ueyama T, Kawamura T, Takagi J, Ogawa Y, Shirakabe K.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 35 Pages: 12343-12352
- DOI
  10.1074/jbc.ra120.013758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18K06911, KAKENHI-PROJECT-20K20581
[Journal Article] Site-specific epitope insertion into recombinant proteins using the MAP tag system.2020
- Author(s)
  Wakasa A, Kaneko MK, Kato Y, Takagi J, and Arimori T.
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 168 Issue: 4 Pages: 375-384
- DOI
  10.1093/jb/mvaa054
- NAID
  40022393375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-20K20581
[Journal Article] The constitutive high affinity Met binding site in the kringle domain is dispensable for the signaling activity of hepatocyte growth factor.2020
- Author(s)
  Umitsu M, Sakai K, Tamura-Kawakami K, Matsumoto K, Takagi J.
- Journal Title
  
  JOURNAL OF BIOCHEMISTRY
  
  Volume: - Issue: 6 Pages: 577-586
- DOI
  10.1093/jb/mvaa006
- NAID
  40022260383
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-20K06553, KAKENHI-PROJECT-19H03499
[Journal Article] Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation2020
- Author(s)
  Bashiruddin Nasir K.、Hayashi Mikihito、Nagano Masanobu、Wu Yan、Matsunaga Yukiko、Takagi Junichi、Nakashima Tomoki、Suga Hiroaki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 49 Pages: 31070-31077
- DOI
  10.1073/pnas.2012266117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-20H00551, KAKENHI-PROJECT-20K20581
[Journal Article] Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization2020
- Author(s)
  Nagae Masamichi、Suzuki Kei、Yasui Norihisa、Nogi Terukazu、Kohno Takao、Hattori Mitsuharu、Takagi Junichi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: mvaa144 Issue: 5 Pages: 1-41
- DOI
  10.1093/jb/mvaa144
- NAID
  40022623693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06575, KAKENHI-PROJECT-20K07051, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-19H03170, KAKENHI-PROJECT-19K22504, KAKENHI-PROJECT-20H03384, KAKENHI-PROJECT-21K19342, KAKENHI-PROJECT-20K20581
[Journal Article] Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.2019
- Author(s)
  Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 12 Issue: 12 Pages: 2955-2955
- DOI
  10.3390/ijms20122955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15306, KAKENHI-PROJECT-17H01399, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-17K07161, KAKENHI-PROJECT-18K19298
[Journal Article] Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.2019
- Author(s)
  Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 10 Pages: 3340-3349
- DOI
  10.1111/cas.14142
- NAID
  120006733132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15306, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-18K19298
[Journal Article] Crystal structure of a mammalian Wnt-frizzled complex.2019
- Author(s)
  Hirai H, Matoba K, Mihara E, Arimori T, Takagi J
- Journal Title
  
  Nature structural & molecular biology
  
  Volume: 26(5) Issue: 5 Pages: 372-379
- DOI
  10.1038/s41594-019-0216-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-18K19298
[Journal Article] Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.2019
- Author(s)
  Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Mukai H, Warashina S, Zouda M, Watanabe Y, Yano S, Shibata M, Suga H, Matsumoto K
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 15 Issue: 6 Pages: 598-606
- DOI
  10.1038/s41589-019-0285-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15306, KAKENHI-PUBLICLY-19H05257, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18H01836, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-18K19287, KAKENHI-PROJECT-18K19298
[Journal Article] Advances in domain and subunit localization technology for electron microscopy.2019
- Author(s)
  Brown ZP, Takagi J
- Journal Title
  
  Biophysical reviews
  
  Volume: 11(2) Issue: 2 Pages: 149-155
- DOI
  10.1007/s12551-019-00513-6
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18K19298
[Journal Article] Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo22019
- Author(s)
  Nagamura Reina、Fukuda Masahiro、Kawamoto Akihiro、Matoba Kyoko、Dohmae Naoshi、Ishitani Ryuichiro、Takagi Junichi、Nureki Osamu
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 75 Issue: 5 Pages: 348-358
- DOI
  10.1107/s2053230x19003546
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18K14639, KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-16H06294
[Journal Article] ラミニン3量体の立体構造解析とインテグリンとの相互作用2019
- Author(s)
  瀧沢士、有森貴夫、谿口征雅、高木淳一、関口清俊
- Journal Title
  
  生物物理
  
  Volume: 59(2) Pages: 91-93
- NAID
  130007620402
- Data Source
  KAKENHI-PROJECT-17H01420
[Journal Article] Structural basis of sarco/endoplasmic reticulum Ca2+-ATPase 2b regulation via transmembrane helix interplay2019
- Author(s)
  Michio Inoue, Nanami Sakuta, Satoshi Watanabe, Yuxia Zhang, Kunihito Yoshikaie, Yoshiki Tanaka, Ryo Ushioda, Yukinari Kato, Junichi Takagi, Tomoya Tsukazaki, Kazuhiro Nagata, Kenji Inaba
- Journal Title
  
  Cell Reports
  
  Volume: 27 Issue: 4 Pages: 1221-1230
- DOI
  10.1016/j.celrep.2019.03.106
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06140, KAKENHI-PUBLICLY-17H05675, KAKENHI-PUBLICLY-18H04871, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-19K22395, KAKENHI-PROJECT-18KK0197, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18H02405, KAKENHI-PROJECT-18K19298
[Journal Article] ラミニン3量体の立体構造解析とインテグリンとの相互作用2019
- Author(s)
  瀧沢士、有森貴夫、谿口征雅、高木淳一、関口清俊
- Journal Title
  
  生物物理
  
  Volume: 59(2) Pages: 91-93
- NAID
  130007620402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19298
[Journal Article] An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system2018
- Author(s)
  Tabata Sanae、Kitago Yu、Fujii Yuki、Mihara Emiko、Tamura-Kawakami Keiko、Norioka Naoko、Takahashi Katsu、Kaneko Mika K.、Kato Yukinari、Takagi Junichi
- Journal Title
  
  Protein Expr Purif.
  
  Volume: 147 Pages: 94-99
- DOI
  10.1016/j.pep.2018.03.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-17K11832
[Journal Article] Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V2018
- Author(s)
  Nagae Masamichi、Kizuka Yasuhiko、Mihara Emiko、Kitago Yu、Hanashima Shinya、Ito Yukishige、Takagi Junichi、Taniguchi Naoyuki、Yamaguchi Yoshiki
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 3380-3380
- DOI
  10.1038/s41467-018-05931-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07303, KAKENHI-PROJECT-17K07356, KAKENHI-PROJECT-18K06914, KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-16H06290, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-15K14481, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16H04758
[Journal Article] Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.2018
- Author(s)
  Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M, Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa Y, Kanai T, Sato T.
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 22 Issue: 3 Pages: 454-467
- DOI
  10.1016/j.stem.2017.12.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09325, KAKENHI-PROJECT-17K15967, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-16J04984, KAKENHI-PROJECT-16J06433, KAKENHI-PROJECT-17J04827, KAKENHI-PROJECT-17H01420, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-17K19612, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy2018
- Author(s)
  Brown Zuben P.、Arimori Takao、Iwasaki Kenji、Takagi Junichi
- Journal Title
  
  J. Struct. Biol.
  
  Volume: 201 Issue: 3 Pages: 247-251
- DOI
  10.1016/j.jsb.2017.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01420
[Journal Article] Facile Synthesis of Dimeric Thioether-Macrocyclic Peptides with Antibody-like Affinity against Plexin-B12018
- Author(s)
  Bashiruddin Nasir K.、Matsunaga Yukiko、Nagano Masanobu、Takagi Junichi、Suga Hiroaki
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 29 Issue: 6 Pages: 1847-1851
- DOI
  10.1021/acs.bioconjchem.8b00219
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-26220204, KAKENHI-PROJECT-17H01420
[Journal Article] Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy2018
- Author(s)
  Tsunoda Jun、Song Chihong、Imai Fabiana Lica、Takagi Junichi、Ueno Hiroshi、Murata Takeshi、Iino Ryota、Murata Kazuyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 15632-15632
- DOI
  10.1038/s41598-018-33977-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19298, KAKENHI-PLANNED-18H05424, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-17H03638, KAKENHI-PROJECT-16K14706, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-18H05425, KAKENHI-PROJECT-26000011
[Journal Article] Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist2018
- Author(s)
  Miao Wenyu、Sakai Katsuya、Ozawa Naoya、Nishiuchi Takumi、Suzuki Yoshinori、Ito Kenichiro、Morioka Tomomi、Umitsu Masataka、Takagi Junichi、Suga Hiroaki、Matsumoto Kunio
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 16492-16492
- DOI
  10.1038/s41598-018-34835-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-26220204, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-16K08544, KAKENHI-PROJECT-16J05654
[Journal Article] Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization2018
- Author(s)
  Kang Sujin、Nakanishi Yoshimitsu、Kioi Yoshiyuki、Okuzaki Daisuke、Kimura Tetsuya、Takamatsu Hyota、Koyama Shohei、Nojima Satoshi、Nishide Masayuki、Hayama Yoshitomo、Kinehara Yuhei、Kato Yasuhiro、Nakatani Takeshi、Shimogori Tomomi、Takagi Junichi、Toyofuku Toshihiko、Kumanogoh Atsushi
- Journal Title
  
  Nature Immunology
  
  Volume: 19 Issue: 6 Pages: 561-570
- DOI
  10.1038/s41590-018-0108-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-18J12007
[Journal Article] Yeast Inner-Subunit PA-NZ-1 Labeling Strategy for Accurate Subunit Identification in a Macromolecular Complex through Cryo-EM Analysis2018
- Author(s)
  Wang Huping、Han Wenyu、Takagi Junichi、Cong Yao
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 430 Issue: 10 Pages: 1417-1425
- DOI
  10.1016/j.jmb.2018.03.026
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-17H01420
[Journal Article] A systematic survey of conformational states in β1 and β4 integrins using negative-stain electron microscopy2018
- Author(s)
  Miyazaki Naoyuki、Iwasaki Kenji、Takagi Junichi
- Journal Title
  
  Journal of Cell Science
  
  Volume: 131 Issue: 10 Pages: 216754-216754
- DOI
  10.1242/jcs.216754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19298, KAKENHI-PROJECT-17H01420
[Journal Article] The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2.2017
- Author(s)
  Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, and Shimomura I.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 19 Pages: 7840-7849
- DOI
  10.1074/jbc.m117.780734
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-16K09801, KAKENHI-PROJECT-16K09802
[Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 15500-15500
- DOI
  10.1038/ncomms15500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-17H01420
[Journal Article] Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability2017
- Author(s)
  Arimori Takao、Kitago Yu、Umitsu Masataka、Fujii Yuki、Asaki Ryoko、Tamura-Kawakami Keiko、Takagi Junichi
- Journal Title
  
  Structure
  
  Volume: 25 Issue: 10 Pages: 1611-1622.e4
- DOI
  10.1016/j.str.2017.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06839, KAKENHI-PROJECT-17H01420
[Journal Article] Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag type IV secretion system2017
- Author(s)
  Koelblen Thomas、Berge Celia、Cherrier Mickael V.、Brillet Karl、Jimenez-Soto Luisa、Ballut Lionel、Takagi Junichi、Montserret Roland、Rousselle Patricia、Fischer Wolfgang、Haas Rainer、Fronzes Remi、Terradot Laurent
- Journal Title
  
  FEBS J.
  
  Volume: 284 Issue: 23 Pages: 4143-4157
- DOI
  10.1111/febs.14299
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Journal Article] Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.2017
- Author(s)
  Sakakibara S., Arimori T., Yamashita K., et al
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 16428-16428
- DOI
  10.1038/s41598-017-16681-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-17K10002
[Journal Article] Structural basis for perception of diverse chemical substances by T1r taste receptors2017
- Author(s)
  Nuemket Nipawan、Yasui Norihisa、Kusakabe Yuko、Nomura Yukiyo、Atsumi Nanako、Akiyama Shuji、Nango Eriko、Kato Yukinari、Kaneko Mika K.、Takagi Junichi、Hosotani Maiko、Yamashita Atsuko
- Journal Title
  
  Nat Commun.
  
  Volume: 8 Issue: 1 Pages: 15530-15530
- DOI
  10.1038/ncomms15530
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05370, KAKENHI-PROJECT-15K00796, KAKENHI-PROJECT-17H01420
[Journal Article] Structural basis for ligand capture and release by the endocytic receptor ApoER2.2017
- Author(s)
  Hirai H, Yasui N, Yamashita K, Tabata S, Yamamoto M, Takagi J, Nogi T
- Journal Title
  
  EMBO reports
  
  Volume: 18 Issue: 6 Pages: 982-999
- DOI
  10.15252/embr.201643521
- NAID
  130007420865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19206, KAKENHI-PROJECT-26291016, KAKENHI-PROJECT-15H05370, KAKENHI-PROJECT-17H01420
[Journal Article] Mechanistic basis for the recognition of laminin-511 by α6β1 integrin2017
- Author(s)
  Takizawa Mamoru、Arimori Takao、Taniguchi Yukimasa、Kitago Yu、Yamashita Erika、Takagi Junichi、Sekiguchi Kiyotoshi
- Journal Title
  
  Science Advances
  
  Volume: 3 Issue: 9
- DOI
  10.1126/sciadv.1701497
- NAID
  120006626420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01420
[Journal Article] Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation and the binding of the Wnt antagonist Dkk1.2017
- Author(s)
  Matoba K, Mihara E, Tamura-Kawakami K, Miyazaki N, Maeda S, Hirai H, Thompson S, Iwasaki K, and Takagi J.
- Journal Title
  
  Cell Rep
  
  Volume: 18 Issue: 1 Pages: 32-40
- DOI
  10.1016/j.celrep.2016.12.017
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] 2D hybrid analysis: Approach for building three-dimensional atomic model by electron microscopy image matching.2017
- Author(s)
  Matsumoto A, Miyazaki N, Takagi J, and Iwasaki K.
- Journal Title
  
  Scientific Rep
  
  Volume: 7 Issue: 1 Pages: 377-377
- DOI
  10.1038/s41598-017-00337-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T cell therapy.2017
- Author(s)
  Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, et al.
- Journal Title
  
  Nat. Med.
  
  Volume: 23 Issue: 12 Pages: 1436-1443
- DOI
  10.1038/nm.4431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15217, KAKENHI-PROJECT-17K19555, KAKENHI-PROJECT-15H04746, KAKENHI-PROJECT-15K09497, KAKENHI-PROJECT-17H01420
[Journal Article] Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors2017
- Author(s)
  Saito Fumiji、Hirayasu Kouyuki、Satoh Takeshi、Wang Christian W.、Lusingu John、Arimori Takao、Shida Kyoko、Palacpac Nirianne Marie Q.、Itagaki Sawako、Iwanaga Shiroh、Takashima Eizo、Tsuboi Takafumi、Kohyama Masako、Suenaga Tadahiro、Colonna Marco、Takagi Junichi、Lavstsen Thomas、Horii Toshihiro、Arase Hisashi
- Journal Title
  
  Nature.
  
  Volume: 552 Issue: 7683 Pages: 101-105
- DOI
  10.1038/nature24994
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08531, KAKENHI-PROJECT-16K08839, KAKENHI-PROJECT-15H02545, KAKENHI-PROJECT-26305009, KAKENHI-PUBLICLY-17H05793, KAKENHI-PROJECT-17H04071, KAKENHI-PROJECT-16K15290, KAKENHI-PROJECT-17H01420
[Journal Article] The PA Tag: A Turn-forming Peptide Tag That Can Be Placed into the Structured Domain of a Protein in a Tailored Manner2016
- Author(s)
  高木淳一
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 56 Issue: 5 Pages: 284-287
- DOI
  10.2142/biophys.56.284
- NAID
  130005264852
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.2016
- Author(s)
  Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T., and Takagi, J.
- Journal Title
  
  Elife
  
  Volume: 5 Pages: 1-19
- DOI
  10.7554/elife.11621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460365, KAKENHI-PROJECT-15K15297, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-26860528, KAKENHI-PROJECT-26293177, KAKENHI-WRAPUP-16H01696, KAKENHI-PROJECT-16K09325
[Journal Article] Structural basis of HGF-Met signaling2016
- Author(s)
  海津正賢、高木淳一
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 27 Issue: 1 Pages: 77-84
- DOI
  10.2491/jjsth.27.77
- NAID
  130005127665
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj52016
- Author(s)
  R. Ushioda, A. Miyamotod, M. Inoue, S. Watanabe, M. Okumurae, K. Maegawa, K. Uegaki, S. Fujii, Y. Fukuda, M. Umitsu, J. Takagi, K. Inaba, K. Mikoshibad, and K. Nagata
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113(41) Issue: 41 Pages: 6055-6063
- DOI
  10.1073/pnas.1605818113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01545, KAKENHI-PUBLICLY-15H01626, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-24227009
[Journal Article] Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.2016
- Author(s)
  Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 478 Issue: 3 Pages: 1274-1279
- DOI
  10.1016/j.bbrc.2016.08.110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-16K10748
[Journal Article] Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.2016
- Author(s)
  Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kaneko M, Kato Y, Takagi J
- Journal Title
  
  J Cell Sci.
  
  Volume: 12- Issue: 7 Pages: 1512-1522
- DOI
  10.1242/jcs.176685
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies.2016
- Author(s)
  Umitsu M, Sakai K, Ogasawara S, Kaneko M, Asaki R, Tamura-Kawakami K, Kato Y, Matsumoto K, Takagi J.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 33149-33149
- DOI
  10.1038/srep33149
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-15K14473
[Journal Article] Molecular Basis of the Ligand-binding Specificity of αvβ8 Integrin.2016
- Author(s)
  Ozawa, A., Sato, Y., Imabayashi, T., Uemura, T., Takagi, J., and Sekiguchi, K.
- Journal Title
  
  The Journal of Biological Chemisry
  
  Volume: 291 Issue: 22 Pages: 11551-11565
- DOI
  10.1074/jbc.m116.719138
- NAID
  120006585485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25291026, KAKENHI-PLANNED-24111006
[Journal Article] Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide.2016
- Author(s)
  Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H.
- Journal Title
  
  Cell Chem Biol
  
  Volume: 23 Issue: 11 Pages: 1341-1350
- DOI
  10.1016/j.chembiol.2016.09.015
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Structure of the plexin ectodomain bound by semaphorin-mimicking antibodies.2016
- Author(s)
  Suzuki K, Tsunoda H, Omiya R, Matoba K, Baba T, Suzuki S, Segawa H, Kumanogoh A, Iwasaki K, Hattori K, Takagi J.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 6 Pages: e0156719-e0156719
- DOI
  10.1371/journal.pone.0156719
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Structural basis for amyloidogenic peptide recognition by sorLA.2015
- Author(s)
  Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 22 Issue: 3 Pages: 199-206
- DOI
  10.1038/nsmb.2954
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-25121738, KAKENHI-PUBLICLY-26110724
[Journal Article] 巨大受容体sorLAによるアミロイドβ分解の促進2015
- Author(s)
  北郷　悠、高木　淳一
- Journal Title
  
  医学のあゆみ(医歯薬出版)
  
  Volume: vol.252(9) Pages: 963-964
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] Interplay of endosomal pH and ligand occupancy in integrin α5β1 ubiquitination, endocytic sorting, and cell migration.2015
- Author(s)
  Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A
- Journal Title
  
  Cell Rep.
  
  Volume: 13 Issue: 3 Pages: 599-609
- DOI
  10.1016/j.celrep.2015.09.024
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] 超高親和性を有する新規アフィニティータグシステム”PAタグシステム”2014
- Author(s)
  藤井勇樹，金子美華，加藤幸成，高木淳一
- Journal Title
  
  和光純薬時報
  
  Volume: 82, 4. Pages: 2-4
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP.2014
- Author(s)
  檜作洋平, 小田隆, 田畑早苗, 川上-田村恵子, 大井里香, 佐藤衛, 高木淳一, 秋山芳展, 禾晃和
- Journal Title
  
  Structure
  
  Volume: 22 Issue: 2 Pages: 326-336
- DOI
  10.1016/j.str.2013.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05188, KAKENHI-PLANNED-21113002, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24370054, KAKENHI-PROJECT-25291037
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp62014
- Author(s)
  Morita J, Kato K, Mihara E, Ishitani R, Takagi J, Nishimasu H, Aoki J, Nureki O
- Journal Title
  
  Acta Crystallogr F Struct Biol Commun
  
  Volume: 70 Issue: 6 Pages: 794-799
- DOI
  10.1107/s2053230x14008929
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-25291011
[Journal Article] Novel role for SORLA/SORL1 as lysosomal sorting receptor for amyloid-b peptide is impaired by familial Alzheimer disease mutation2014
- Author(s)
  Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Fuchtbauer E-M, Fachtbauer A, Holtzman DM, Takagi J, and Wilnow TE
- Journal Title
  
  Science Translational Medicine
  
  Volume: 6(223) Issue: 223
- DOI
  10.1126/scitranslmed.3007747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00097, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin2014
- Author(s)
  Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J.
- Journal Title
  
  Protein Expr Purif
  
  Volume: 95 Pages: 240-247
- DOI
  10.1016/j.pep.2014.01.009
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24651260, KAKENHI-PUBLICLY-25121729
[Journal Article] 新規アフィニティータグ“PA タグ”の利用法～蛋白質の精製および検出～2014
- Author(s)
  藤井勇樹, 金子美華, 加藤幸成, 高木淳一
- Journal Title
  
  蛋白質科学会アーカイブ
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] Editorial overview: New constructs and expression of proteins: Making things better.2014
- Author(s)
  Takagi, J. and Tate, CG.
- Journal Title
  
  Curr Opin Struct Biol.
  
  Volume: 26 Pages: iv-vi
- DOI
  10.1016/j.sbi.2014.05.001
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration2013
- Author(s)
  Nojima S, et al.
- Journal Title
  
  Nat Commun
  
  Volume: 4 Issue: 1 Pages: 1406-1406
- DOI
  10.1038/ncomms2420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-23390069, KAKENHI-PROJECT-23590425, KAKENHI-PROJECT-23591244, KAKENHI-PROJECT-23790444, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24651260
[Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013
- Author(s)
  Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
- Journal Title
  
  Protein Science
  
  Volume: 22 Issue: 6 Pages: 840-850
- DOI
  10.1002/pro.2254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24651260, KAKENHI-PROJECT-24657097, KAKENHI-PLANNED-24112008
[Journal Article] 相関構造解析法による階層をまたがった生命機能の統合的解明2013
- Author(s)
  高木淳一
- Journal Title
  
  パリティ
  
  Volume: 28-07
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] Correlative Light-electron Microscopy: The Synapse Adhesion Mechanism2013
- Author(s)
  宮崎直幸；田中宏樹；禾　晃和；高木淳一；岩崎憲治.
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 53 Issue: 4 Pages: 218-221
- DOI
  10.2142/biophys.53.218
- NAID
  10031178748
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo2013
- Author(s)
  Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y,
- Journal Title
  
  Sci Transl Med
  
  Volume: 5 Issue: 181
- DOI
  10.1126/scitranslmed.3004387
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013
- Author(s)
  Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
- Journal Title
  
  J. Thromb. Haemost.
  
  Volume: (In press) Issue: 7 Pages: 1399-1406
- DOI
  10.1111/jth.12279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060
[Journal Article] セマフォリン関連分子群の立体構造2013
- Author(s)
  松永幸子、高木淳一
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 523-530
- Data Source
  KAKENHI-PROJECT-24651260
[Journal Article] Schwann cell myelination requires integration of laminin activities2012
- Author(s)
  Karen K. McKee
- Journal Title
  
  Journal of Cell Science
  
  Volume: 125 Pages: 4609-4619
- DOI
  10.1242/jcs.107995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-24651260, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp12012
- Author(s)
  Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
- Journal Title
  
  Acta Crystallogr
  
  Volume: F68 Issue: 7 Pages: 778-782
- DOI
  10.1107/s1744309112019306
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-24651260, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Tilt-angle measurement of a sample stage using a capacitive liquid-based inclinometer2012
- Author(s)
  M.Matoba, et al
- Journal Title
  
  J.Electron.Microsc.
  
  Volume: 61(3) Pages: 193-198
- DOI
  10.1093/jmicro/dfs034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241030, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22310079, KAKENHI-PROJECT-24657075, KAKENHI-ORGANIZER-24111001
[Journal Article] Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling2012
- Author(s)
  Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O
- Journal Title
  
  Proc. Natl Acad. Sci. U. S. A.
  
  Volume: 109 Issue: 42 Pages: 16876-16881
- DOI
  10.1073/pnas.1208017109
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-24651260, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用2012
- Author(s)
  北郷悠、高木淳一
- Journal Title
  
  The Lipid
  
  Volume: 23 Pages: 56-62
- Data Source
  KAKENHI-PROJECT-24651260
[Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用2012
- Author(s)
  北郷悠、高木淳一
- Journal Title
  
  The Lipid
  
  Volume: 23(4) Pages: 56-62
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Crystal structure of α5β1 integrin ectodomain : Atomic details of the fibronectin receptor2012
- Author(s)
  Nagae, M., et al.
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 197 Issue: 1 Pages: 131-140
- DOI
  10.1083/jcb.201111077
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22370039, KAKENHI-PROJECT-24770111, KAKENHI-PUBLICLY-23121520, KAKENHI-PUBLICLY-24110520, KAKENHI-ORGANIZER-24111001
[Journal Article] Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.2012
- Author(s)
  Takagi, S
- Journal Title
  
  Blood
  
  Volume: 119 Issue: 12 Pages: 2768-2777
- DOI
  10.1182/blood-2011-05-353201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23591561, KAKENHI-PROJECT-24229004, KAKENHI-ORGANIZER-24111001
[Journal Article] Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin2012
- Author(s)
  Tanaka, H., Miyazaki, N., Matoba, K., Nogi, T., Iwasaki, K., and Takagi, J
- Journal Title
  
  Cell Reports
  
  Volume: 2(1) Issue: 1 Pages: 101-110
- DOI
  10.1016/j.celrep.2012.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22370039, KAKENHI-PROJECT-24651260, KAKENHI-PUBLICLY-23121520, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Functional importance of covalent homodimer of reelin linked via its central region2011
- Author(s)
  Yasui, N., et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 40 Pages: 35247-35256
- DOI
  10.1074/jbc.m111.242719
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22390016, KAKENHI-PROJECT-22890155, KAKENHI-PUBLICLY-23123519
[Journal Article] Crystallization and preliminary crystallographic anal-ysis of human LR11 Vps10p domain2011
- Author(s)
  Nakata Z, Nagae M, Yasui N, Bujo H, Nogi T, Takagi J
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun
  
  Volume: 67 Issue: 1 Pages: 129-132
- DOI
  10.1107/s1744309110048153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390277, KAKENHI-PUBLICLY-22121513, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22370039
[Journal Article] Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin2011
- Author(s)
  Tanaka, H., et al.
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 4 Pages: e19411-e19411
- DOI
  10.1371/journal.pone.0019411
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22370039
[Journal Article] Comparison of the envelope architecture of E.coli using two methods : CEMOVIS and cryo-electron tomography.2010
- Author(s)
  Kishimoto-Okada, A., Takagi J., et al.
- Journal Title
  
  J.Electron Microsc.
  
  Volume: 59 Pages: 419-493426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Comparison of the envelope architecture of E. coli using two methods: CEMOVIS and cryo-electron tomography2010
- Author(s)
  Kishimoto-Okada, A., Murakami, S., Ito, Y., Horii, N., Furukawa, H., Takagi, J., Iwasaki, K
- Journal Title
  
  J. Electron Microsc
  
  Volume: 59 Issue: 5 Pages: 419-426
- DOI
  10.1093/jmicro/dfq056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Structural basis for semaphorin signaling through the plexin receptor.2010
- Author(s)
  Nogi, T., Takagi J., et al.
- Journal Title
  
  Nature
  
  Volume: 467 Pages: 1123-1127
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513
[Journal Article] Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation.2010
- Author(s)
  Yasui N, Mihara E, Nampo M, Tamura-Kawakami K, Unno H, Matsumoto K, Takagi
- Journal Title
  
  J. immunol. Methods 352
  
  Pages: 153-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structural basis for specific recognition of reelin by its receptors.2010
- Author(s)
  Yasui N, Nogi T, Takagi J.
- Journal Title
  
  Structure
  
  Volume: 18 Pages: 320-331
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513
[Journal Article] Crystallization and preliminary crystallographic analysis of human LR11 Vps10p domain.2010
- Author(s)
  Nakata, Z., Takagi J., et al.
- Journal Title
  
  Acta Crystallographica.F
  
  Volume: 67 Pages: 129-132
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513
[Journal Article] Laminin-121-Recombinant expression and interactions with integrins.2010
- Author(s)
  Sasaki, T., Takagi J., et al.
- Journal Title
  
  Matrix Biology
  
  Volume: 29 Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513
[Journal Article] Structural basis for specific recognition of reelin by its receptors.2010
- Author(s)
  Yasui N, Nogi T, Takagi
- Journal Title
  
  Structure 18
  
  Pages: 320-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structural basis for semaphorin signaling through the plexin receptor.2010
- Author(s)
  Nogi, T., Takagi J., et al.
- Journal Title
  
  Nature
  
  Volume: 467 Pages: 1123-1127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Structural basis for specific recognition of reelin by its receptors.2010
- Author(s)
  Yasui N, Nogi T, Takagi J.
- Journal Title
  
  Structure
  
  Volume: 18 Pages: 320-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Comparison of the envelope architecture of E.coli using two methods : CEMOVIS and cryo-electron tomography.2010
- Author(s)
  Kishimoto-Okada, A., Takagi J., et al.
- Journal Title
  
  J.Electron Microsc.
  
  Volume: 59 Pages: 419-493426
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513
[Journal Article] Laminin-121-Recombinant expression and interactions with integrins.2010
- Author(s)
  Sasaki, T., Takagi J., et al.
- Journal Title
  
  Matrix Biology
  
  Volume: 29 Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Structural basis for semaphorin signalling through the plexin receptor2010
- Author(s)
  Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J.
- Journal Title
  
  Nature
  
  Volume: 467(7319) Issue: 7319 Pages: 1123-7
- DOI
  10.1038/nature09473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22370039
[Journal Article] Crystallization and preliminary crystallographic analysis of human LR11 Vps10p domain2010
- Author(s)
  Nakata, Z., Takagi J., et al.
- Journal Title
  
  Acta Crystallographica.F
  
  Volume: 67 Pages: 129-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation.2010
- Author(s)
  Yasui N, Takagi J., et al.
- Journal Title
  
  J.Immunol.Methods
  
  Volume: 352 Pages: 153-160
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121513
[Journal Article] Detection of endogenous LRP6 expressed on human cells by monoclopal antibodies specific for the native conformation2010
- Author(s)
  Yasui N, Takagi J., et al.
- Journal Title
  
  J.Immunol.Methods
  
  Volume: 352 Pages: 153-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247010
[Journal Article] Production, crystallization and preliminary crystallographic analysis of the exosite-containing fragment of human von Willebrand factor-cleaving proteinase, ADAMTS 13.2009
- Author(s)
  Akiyama, M., Takeda, S., Kokame, K., L Takagi., Miyata, T.
- Journal Title
  
  Acta Crystallographica. F65
  
  Pages: 739-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structural insights into von Willebrand factor cleavage by ADAMTS13.2009
- Author(s)
  Akiyama, M., Takeda, S., Kokame, K., L Takagi, Miyata, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Molecular basis of the recognition of nephronectin by integrin alpha8betal.2009
- Author(s)
  Sato, Y., Uemura, T., Morimitsu, K., Sato-Nishiuchi, R., Manabe, R., Takagi, J., Yamada, M., Sekiguchi, K.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 14524-14536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Key interactions in ectodomain of integrin for global conformational change detected by elastic network normal mode analysis.2008
- Author(s)
  Atsushi Matsumoto, Tetsuji Kamata, Junichi Takagi, Kenji Iwasaki, Kei Yura.
- Journal Title
  
  Biophys. J. 95(6)
  
  Pages: 2895-2908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structure of F-spondin reeler domain reveals a unique β-sandwich fold with a deformable disulfide-bonded loop.2008
- Author(s)
  Nagae, M., Nishikawa, K., Yasui, N., Yamasaki, M., Nogi, T., Takagi, J.
- Journal Title
  
  Acta Crystallographica D64
  
  Pages: 1138-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] A murine monoclonal antibody that binds N-terminal extracellular segment of human protease activated receptor-4.2008
- Author(s)
  Sangawa, T., Nogi, T., Takagi, J.
- Journal Title
  
  Hybridoma 27(5)
  
  Pages: 331-335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Novel affinity tag system using structurally defined antibody-tag interaction: Application to single-step protein purification.2008
- Author(s)
  Nogi, T., Sangawa, T., Tabata, S., Nagae, M., Tamura-Kawakami, K., Beppu, A., Hattori, M., Yasui, N., Takagi, J.
- Journal Title
  
  Protein Sci. 17
  
  Pages: 2120-2126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus.2008
- Author(s)
  Yamaguchi, H., Takagi, J., Miyamae, T., Yokota, S., Fujimoto, T., Nakamura, S., Ohshima, S., Naka, T., Nagata, S.
- Journal Title
  
  J. Leukocyte Biol. 83
  
  Pages: 1300-1307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structure of a receptor-binding reelin fragment and mutational analysis reveal a recognition mechanism similar to endocytic receptors2007
- Author(s)
  Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M.,Takagi J
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 9988-9993
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structural basis for ligand recognition by integrins.2007
- Author(s)
  Takagi, J.
- Journal Title
  
  Curr. Opin. Cell Biol. 19
  
  Pages: 557-564
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Three-dimensional architecture of virus-packed tubule.2007
- Author(s)
  Katayama, S., Wei, T., Omura, T., Takagi., Iwasaki, K.
- Journal Title
  
  J. Electron Microsc. 56
  
  Pages: 77-81
- NAID
  10028200118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structural basis for ligand recognition by integrins2007
- Author(s)
  Takagi, J
- Journal Title
  
  Curr. Opin. Cell Biol 19
  
  Pages: 557-564
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structural basis for ligand recognition by integrins.2007
- Author(s)
  Takagi, Junichi
- Journal Title
  
  Curr. Opin. Cell Biol. 19
  
  Pages: 557-564
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Semaphorin 7A initiates T cell-mediated inflammatory responses through al b1 integrin2007
- Author(s)
  Suzuki, K., Okuno, T., Yamamoto, M., Pasterkamp, R.J., Takegahara, N., Kitao, T., Takagi, J., Rennert, P.D., Kolodkin, A.L., Kumanogoh, A., Kikutani, H
- Journal Title
  
  Nature 446
  
  Pages: 680-684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] van der Merwe PA, Mardon HJ, and Handford PA alpha Vbeta 6 is a novel receptor for human fibrillin-1 : comparative studies of molecular determinants underlying integrin-RGD affinity and specificity2007
- Author(s)
  Jovanovic, J, Takagi, J, Choulier, L, Abrescia, NG, Stuart, DI
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 6743-6751
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Semaphorin 7A initiates T cell-mediated inflammatory responses through a1131 integrin.2007
- Author(s)
  Suzuki K., Okuno, T., Yamamoto, M., Pasterkamp, R.J., Takegahara, N., Kitao, T., Takagi, J., Rennert, P.D., Kolodkin, A.L., Kumanogoh, A., Kikutani, H.
- Journal Title
  
  Nature 446
  
  Pages: 680-684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Three-dimensional architecture of virus-packed tubule2007
- Author(s)
  Katayama, S., Wei, T., Omura, T., Takagi, J., Iwasaki, K
- Journal Title
  
  J. Electron Micmac 56
  
  Pages: 77-81
- NAID
  10028200118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] aVr36 is a novel receptor for human fibrillin-1: comparative studies of molecular determinants underlying integrin-RGD affinity and specificity.2007
- Author(s)
  Jovanovic J, Takagi J, Choulier L, Abrescia NG, Stuart DI, van der Merwe PA, Mardon HJ, Handford PA
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 6743-6751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] The RGD motif in fibronectin is essential for mouse development but dispensable for fibronectin fibril assembly2007
- Author(s)
  Takahashi, S., Leiss, M., Moser, M., Ohashi, T., Kitao, T., Heckmann, D., Pfeifer, A., Kessler, H., Takagi, T. Erickson, H.P., Fassler, R
- Journal Title
  
  J. Cell Biol 178
  
  Pages: 167-178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structural basis for ligand recognition by integrins.2007
- Author(s)
  Takagi, Junichi
- Journal Title
  
  Curr. Opin. Cell Biol. 19
  
  Pages: 557-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] receptor-binding reelin fragment and mutational analysis reveal a recognition mechanism similar to endocytic receptors.2007
- Author(s)
  Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M., Takagi, J.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 9988-9993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] The RGD motif in fibronectin is essential for mouse development but dispensable for fibronectin fibril assembly.2007
- Author(s)
  Takahashi, S., Leiss, M., Moser, M., Ohashi, T., Kitao, T., Heckmann, D., Pfeifer, A., Kessler, H., Takagi, T., Erickson, H.P., Fassler, R.
- Journal Title
  
  J. Cell Biol. 178
  
  Pages: 167-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Ligand-binding specificities of laminin-binding integrins : a comprehensive survey of laminin-integrin interactions using recombinant alpha3betal, a6b1, a7b1 and a6b4 integrins2006
- Author(s)
  Nishiuchi, R., Takagi, J., Hayashi, M., Ido, H., Yagi, Y., Sanzen, N., Tsuji, T., Yamada, M., Sekiguchi, K
- Journal Title
  
  Matrix Blot 25
  
  Pages: 189-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] モジュラータンパク質の構造解析:受容体構造生物学における中心課題2006
- Author(s)
  高木、淳一
- Journal Title
  
  日本結晶学会誌 48
  
  Pages: 411-417
- NAID
  10018467400
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] モジュラータンパク質の構造解析 : 受容体構造生物学における中心課題2006
- Author(s)
  高木淳一
- Journal Title
  
  日本結晶学会誌 48
  
  Pages: 411-417
- NAID
  10018467400
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] モジュラータンパク質の構造解析:受容体構造生物学における中心課題2006
- Author(s)
  高木淳一
- Journal Title
  
  日本結晶学会誌 48
  
  Pages: 411-417
- NAID
  10018467400
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Direct interaction of the kringle domain of urokinase-type plasminogen activator(uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation.2006
- Author(s)
  Tarui, T., Akakura, N., Majumdar, M., Andronicos, N., Takagi, J., Mazar, A.P., Bdeir, K., Kuo, A., Yarovoi, S.V., Cines, D.B., Takada, Y
- Journal Title
  
  Thromb Haemost 95
  
  Pages: 524-534
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structural analysis of modular proteins2006
- Author(s)
  Takagi, J
- Journal Title
  
  Nihon Kessyou Gakkaishi 48
  
  Pages: 411-417
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] モジュラータンパク質の構造解析 : 受容体構造生物学における中心課題2006
- Author(s)
  高木, 淳一
- Journal Title
  
  日本結晶学会誌 48
  
  Pages: 411-417
- NAID
  10018467400
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography.2006
- Author(s)
  Nogi, T., Yasui, N., Hattori, M., Iwasaki, K., Takagi, J.
- Journal Title
  
  EMBO J. 25
  
  Pages: 3675-3683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structure of a signaling-competent reelin fragment revealed by X-ray crystallo-graphy and electrdn tomography2006
- Author(s)
  Nogi, T., Yasui, N., Hattori, M., Iwasaki, K., Takagi, J
- Journal Title
  
  EMBO J 25
  
  Pages: 3675-3683
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering2005
- Author(s)
  Luo, B. H., Carman, C. V., Takagi, J., Springer, T. A
- Journal Title
  
  Proc Nati Acad Sci USA102
  
  Pages: 3679-3684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] レセプター膜貫通ドメインの構造とそのシグナリングにおける動的制御2005
- Author(s)
  高木淳一
- Journal Title
  
  蛋白質核酸酵素 50(10)
  
  Pages: 1226-1232
- Data Source
  KAKENHI-PROJECT-17053015
[Journal Article] Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.2005
- Author(s)
  Luo, B.H., Carman, C.V., Takagi, J., Springer, T.A.
- Journal Title
  
  Proc Natl Acad Sci U S A 102
  
  Pages: 3679-3684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] レセプター膜貫通ドメインの構造とそのシグナリングにおける動的制御2005
- Author(s)
  高木淳一
- Journal Title
  
  蛋白質核酸酵素 50(10)
  
  Pages: 1226-1232
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Higher-order structural analysis of proteins by electron microscopy2005
- Author(s)
  Iwasaki, K, Takagi, J
- Journal Title
  
  Seikagaku 77
  
  Pages: 400-410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structure of receptor transmembrane domain and its dynamic regulation during the signaling2005
- Author(s)
  Takagi, J
- Journal Title
  
  Tampakushitsu Kakusan Kouso 50(10)
  
  Pages: 1226-1232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Potentiation of the ligand-binding activity of integrin alpha3 betal via association with tetraspanin CD151.2005
- Author(s)
  Nishiuchi, R., Sanzen, N., Nada, S., Sumida, Y., Wada, Y., Okada, M., Takagi, J., Hasegawa, H., Sekiguchi, K.
- Journal Title
  
  Proc Natl Acad Sci U S A 102
  
  Pages: 1939-1944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Potentiation of the ligand-binding activity of integrin alpha3 betal via association with tetraspanin CD1512005
- Author(s)
  Nishiuchi, R., Sanzen, N., Nada, S., Sumida, Y., Wada, Y., Okada, M., Takagi, J., Hasegawa, H., Sekiguchi, K
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 1939-1944
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] レセプター膜貫通ドメインの構造とそのシグナリングにおける動的制御2005
- Author(s)
  高木、淳一
- Journal Title
  
  蛋白質核酸酵素 50(10)
  
  Pages: 1226-1232
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] 電子顕微鏡を用いた蛋白質の高次構造解析が開く世界-インテグリンレセプターの構造解析を中心として-2005
- Author(s)
  岩崎憲治、高木淳一
- Journal Title
  
  生化学 77
  
  Pages: 400-410
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] レセプター膜貫通ドメインの構造とそのシグナリングにおける動的制御2005
- Author(s)
  高木淳一
- Journal Title
  
  蛋白質核酸酵素 50(10)
  
  Pages: 1226-1232
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structural basis for ligand recognition by RGD(Arg-Gly-Asp)-dependent integrins.2004
- Author(s)
  Takagi, J
- Journal Title
  
  Biochem Soc. Trans 32
  
  Pages: 403-406
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins.2004
- Author(s)
  Takagi, Junichi
- Journal Title
  
  Biochem Soc Trans 32
  
  Pages: 403-406
- Data Source
  KAKENHI-PROJECT-16048215
[Journal Article] Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins.2004
- Author(s)
  Takagi, Junichi
- Journal Title
  
  Biochem Soc Trans 32
  
  Pages: 403-406
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides2004
- Author(s)
  Luo, B. H., Takagi, J., Springer, T A
- Journal Title
  
  J Biol Chem 279
  
  Pages: 10215-10221
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Journal Article] Structural basis for ligand recognition by RGD(Arg-Gly-Asp)-dependent integrins.2004
- Author(s)
  Takagi, Junichi
- Journal Title
  
  Biochem Soc Trans 32
  
  Pages: 403-406
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Patent] 歯の再生治療のためのＵＳＡＧ－１を標的分子とした中和抗体2019
- Inventor(s)
  高橋克、菅井学、時田義人、高木淳一、三原恵美子
- Industrial Property Rights Holder
  高橋克、菅井学、時田義人、高木淳一、三原恵美子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-130153
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H01420
[Patent] プレキシンの結合調節剤2017
- Inventor(s)
  菅裕明、バシルディン　ナセル、高木淳一、松永幸子
- Industrial Property Rights Holder
  菅裕明、バシルディン　ナセル、高木淳一、松永幸子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-17H01420
[Patent] 環状ペプチドをタンパク質構造に提示させる超汎用法2017
- Inventor(s)
  菅裕明、高木淳一
- Industrial Property Rights Holder
  菅裕明、高木淳一
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-17H01420
[Patent] Fragment Antibody and Method for Crystallizing Protein using Fragment Antibody2017
- Inventor(s)
  Junichi Takagi
- Industrial Property Rights Holder
  Junichi Takagi
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H01420
[Patent] 細胞培養培地、培養方法、およびオルガノイド2016
- Inventor(s)
  佐藤俊朗、股野麻未、高木淳一
- Industrial Property Rights Holder
  佐藤俊朗、股野麻未、高木淳一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-029060
- Filing Date
  2016-02-18
- Data Source
  KAKENHI-PLANNED-24111006
[Patent] プレキシンの結合調節剤2016
- Inventor(s)
  菅裕明、バシルディン　ナセル、高木淳一、松永幸子
- Industrial Property Rights Holder
  菅裕明、バシルディン　ナセル、高木淳一、松永幸子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-120226
- Filing Date
  2016-06-16
- Data Source
  KAKENHI-PLANNED-24111006
[Patent] フラグメント抗体及び当該フラグメント抗体を用いるタンパク質の結晶化法2016
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  高木淳一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-218631
- Filing Date
  2016-11-09
- Data Source
  KAKENHI-PLANNED-24111006
[Patent] Wntタンパク質の安定な製造法および保存法2014
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  高木淳一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-260792
- Filing Date
  2014-12-24
- Data Source
  KAKENHI-PLANNED-24111006
[Patent] タグペプチド及びその利用2013
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Acquisition Date
  2013-05-02
- Data Source
  KAKENHI-PROJECT-22247010
[Patent] TAG PEPTIDE HAVING A PROTEASE RECOGNITION SEQUENCE AND USE THEREOF2012
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Acquisition Date
  2012-12-26
- Overseas
- Data Source
  KAKENHI-PROJECT-22247010
[Patent] プロテアーゼ認識配列を有するタグペプチドおよびその利用2009
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Number
  2009-103925
- Filing Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-17082004
[Patent] タグペプチド及びその利用2008
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Filing Date
  2008-12-18
- Overseas
- Data Source
  KAKENHI-PROJECT-17082004
[Patent] タグペプチドが結合した融合タンパク質、タグペプチドに対する抗体及びこれらを用いるタンパク質の精製方法2008
- Inventor(s)
  高木淳一
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Number
  2008-020804
- Filing Date
  2008-01-31
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 受容体の構造生物学研究から新しいバイオ医薬の創製へ2022
- Author(s)
  高木　淳一
- Organizer
  新適塾「未来創薬への誘い」
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] LassoGraft Technologyによる新規バイオ医薬品モダリティの創成2022
- Author(s)
  高木淳一
- Organizer
  次世代モダリティ研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] The "Lasso-grafted" Fc Design Platform Offers Creation of Novel Receptor Agonists and Antagonists2022
- Author(s)
  Junichi Takagi
- Organizer
  The 68th NIBB Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] 受容体構造生物学から創薬へ -LassoGraft Technologyと受容体作動薬の開発-2022
- Author(s)
  高木淳一
- Organizer
  量子構造生物学委員会第8回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] LassoGraft Technologyによる新規バイオ医薬品モダリティの創成2022
- Author(s)
  高木淳一
- Organizer
  大阪大学工学研究科テクノアリーナ・フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] ラッソ・グラフト法を用いた抗体の高付加価値化技術2022
- Author(s)
  高木淳一
- Organizer
  第８回蛋白質創薬学分野講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] 高親和性受容体デコイによる“エスケープフリー”のCOVID-19治療薬創製2022
- Author(s)
  高木淳一
- Organizer
  創薬薬理フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] 受容体の構造生物学研究から新しいバイオ医薬の創製へ2022
- Author(s)
  高木淳一
- Organizer
  12th INA Chemical Biology Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] Fcを基盤としたバイオ医薬モダリティ“Mirabody”による受容体機能の修飾2022
- Author(s)
  高木淳一
- Organizer
  第一回日本抗体学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] 受容体の構造生物学研究から新しいバイオ医薬の創製へ2022
- Author(s)
  高木　淳一
- Organizer
  2021年度中性子構造生物学研究会　「タンパク質科学・構造生物学と創薬への展開」
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] LassoGraft Technology allows rapid and simple generation of engineered AAV vectors with defined receptor dependency2021
- Author(s)
  高木　淳一
- Organizer
  第27回日本遺伝子細胞治療学会学術集会　プレナリーセッション
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] Structural Mechanism of Laminin Recognition by Integrins2021
- Author(s)
  高木　淳一
- Organizer
  American Society for Matrix Biology Biennial Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] Instant formulation of multispecific binders using LassoGraft Technology,2021
- Author(s)
  Junichi Takagi
- Organizer
  PepTalk2021( Characterization of Biotherapeutics)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20581
[Presentation] LassoGraft Technology による新規バイオ医薬品モダリティの創成2021
- Author(s)
  高木　淳一
- Organizer
  第114回未来医療セミナー（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] BINDS支援と高度化で進んだ「日本発のバイオ医薬」創出2021
- Author(s)
  高木　淳一
- Organizer
  2021年度AMED/BINDSセミナー（構造解析ユニット）―成果と今後の展望―
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] Instant formulation of multispecific binders using LassoGraft Technology,2021
- Author(s)
  Junichi Takagi
- Organizer
  PepTalk2021( Characterization of Biotherapeutics)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] LassoGraft Technology による新規バイオ医薬品モダリティの創成2021
- Author(s)
  高木　淳一
- Organizer
  第21回日本蛋白質科学会年会　シンポジウムS「蛋白質科学が社会へ与えるインパクト　ーAMED-BINDSから次のステージへー」
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] "Neobiologics" - New modality of multi-functional protein biologics with simple design concept -2021
- Author(s)
  高木　淳一
- Organizer
  蛋白研セミナー「Antibody engineering with AI towards next generation drug discovery」
- Invited
- Data Source
  KAKENHI-PROJECT-20H00455
[Presentation] LassoGraft Technology による新規バイオ医薬品モダリティの創成2021
- Author(s)
  高木　淳一
- Organizer
  第114回未来医療セミナー（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-20K20581
[Presentation] X線とクライオ電顕で迫るラミニン結合性インテグリンα6β1の構造2019
- Author(s)
  高木　淳一
- Organizer
  第二回構造生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Structural Mechanism of Laminin Recognition by Integrins2019
- Author(s)
  高木　淳一
- Organizer
  Gordon Research Conference 2019 -Fibronectin, Integrins and Related Molecules-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Screening of compounds modulating the expression profile of Alzheimer's rist factor, SORL12019
- Author(s)
  Yu Kitago, Lavoisier Ramos-Espiritu, Rui Wu, Rebecca Cox, J Fraser Glickman, Greg A Petsko, Junichi Takagi
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] LassoGraft Technology による新規バイオ医薬品モダリティの創成2019
- Author(s)
  高木　淳一
- Organizer
  第５回蛋白質工学研究会ワークショップ『産業展開と構造生物学』
- Invited
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] ダイナミックな運動性をもつマルチドメイン蛋白質HGFの高難度結晶化の試み2019
- Author(s)
  中村希、岩佐奈実、川上紗代子、有森貴夫、酒井克也、松本邦夫、高木淳一
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] Redesigning the small antibody fragment “Fv-clasp” by using heterodimeric SARAH domains2019
- Author(s)
  Mercy Egrina Adiniko, Takao Arimori, Junichi Takagi
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] ダイナミックな運動性をもつマルチドメイン蛋白質HGFの高難度結晶化の試み2019
- Author(s)
  中村希、岩佐奈実、川上紗代子、有森貴夫、酒井克也、松本邦夫、高木淳一
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Crystal structure of human Wnt3 reveals its signaling mechanism on cell surface2019
- Author(s)
  高木　淳一
- Organizer
  Seminar at Universita Cattolica del Sacro Cuore
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Crystal structure of human Wnt3 in complex with mouse Frizzled 82019
- Author(s)
  高木　淳一、平井秀憲、的場京子、有森貴夫、三原恵美子
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会 Joint Symposium “New perspectives on Wnt signaling, unveiled by structural and cell biology”
- Invited
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] Crystal structure of human Wnt3 reveals its signaling mechanism on cell surface2019
- Author(s)
  高木　淳一
- Organizer
  Seminar at Universita Cattolica del Sacro Cuore
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] LassoGraft Technologyによる新規バイオ医薬品モダリティの創成2019
- Author(s)
  高木　淳一
- Organizer
  第92回日本生化学会大会シンポジウム「日本発新バイオ医薬品イノベーションを目指す最先端創薬」
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Redesigning the small antibody fragment “Fv-clasp” by using heterodimeric SARAH domains2019
- Author(s)
  Mercy Egrina Adiniko, Takao Arimori, Junichi Takagi
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] LassoGraft Technologyによる新規バイオ医薬品モダリティの創成2019
- Author(s)
  高木　淳一
- Organizer
  第92回日本生化学会大会シンポジウム「日本発新バイオ医薬品イノベーションを目指す最先端創薬」
- Invited
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] Screening of compounds modulating the expression profile of Alzheimer's rist factor, SORL12019
- Author(s)
  Yu Kitago, Lavoisier Ramos-Espiritu, Rui Wu, Rebecca Cox, J Fraser Glickman, Greg A Petsko, Junichi Takagi
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] LassoGraft Technology による新規バイオ医薬品モダリティの創成2019
- Author(s)
  高木　淳一
- Organizer
  第５回蛋白質工学研究会ワークショップ『産業展開と構造生物学』
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] X線とクライオ電顕で迫るラミニン結合性インテグリンα6β1の構造2019
- Author(s)
  高木　淳一
- Organizer
  第二回構造生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] 理学研究者が行うタンパク質工学～アカデミアが目指すべき技術開発とは？2019
- Author(s)
  高木　淳一
- Organizer
  2019年度生物工学若手研究者の集い　夏のセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] 抗MAPタグ抗体の結晶構造とMAPタグシステムの新たな応用法2019
- Author(s)
  有森貴夫，若狭彩美，金子美華，加藤幸成，高木淳一
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Crystal structure of human Wnt3 in complex with mouse Frizzled 82019
- Author(s)
  高木　淳一、平井秀憲、的場京子、有森貴夫、三原恵美子
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会 Joint Symposium “New perspectives on Wnt signaling, unveiled by structural and cell biology”
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Structural Mechanism of Laminin Recognition by Integrins2019
- Author(s)
  高木　淳一
- Organizer
  Gordon Research Conference 2019 -Fibronectin, Integrins and Related Molecules-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] 抗MAPタグ抗体の結晶構造とMAPタグシステムの新たな応用法2019
- Author(s)
  有森貴夫，若狭彩美，金子美華，加藤幸成，高木淳一
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] 理学研究者が行うタンパク質工学～アカデミアが目指すべき技術開発とは？2019
- Author(s)
  高木　淳一
- Organizer
  2019年度生物工学若手研究者の集い　夏のセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] Use of small and stable antibody scaffold Fv-clasp to facilitate structural studies of drug-target molecules2018
- Author(s)
  Junichi Takagi
- Organizer
  The 10th annual PEGS Europe “Protein&Antibody Engineering Summit”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] Plexin crosslinking by divalent artificial binders differentially controls its signaling state.2018
- Author(s)
  Junichi Takagi
- Organizer
  The EMBO Workship “Molecular Neurobiology”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Use of small and stable antibody scaffold Fv-clasp to facilitate structural studies of drug-target molecules2018
- Author(s)
  Junichi Takagi
- Organizer
  The 10th annual PEGS Europe “Protein&Antibody Engineering Summit”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] プレキシン二量体化による忌避性シグナル伝達の構造的基盤2018
- Author(s)
  高木淳一
- Organizer
  第89回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Plexin crosslinking by divalent artificial binders differentially controls its signaling state.2018
- Author(s)
  Junichi Takagi
- Organizer
  The EMBO Workship “Molecular Neurobiology”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] プレキシン二量体化による忌避性シグナル伝達の構造的基盤2018
- Author(s)
  高木淳一
- Organizer
  第89回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K19298
[Presentation] EM visualization of LRP6 ectodomain ~N-glycosylation, conformational freedom, and signaling activity~2017
- Author(s)
  高木淳一
- Organizer
  Gordon Research Conference ”Wnt signaling”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] プロテアーゼ切断によるHGF活性化の構造的基盤2017
- Author(s)
  高木淳一
- Organizer
  金沢大学がん進展制御研究所、共同利用・共同研究拠点シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Crystallization and structure determination of laminin-binding integrin α6β1 aided by the use of Fv-clasp technology2017
- Author(s)
  有森貴夫，高木淳一
- Organizer
  第55回　日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] 特殊環状ペプチドによる受容体-リガンド相互作用のアロステリック阻害2017
- Author(s)
  高木淳一
- Organizer
  近畿化学協会合成部会　第1回合成フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] 新しい低分子抗体フォーマットFv-claspとその結晶化シャペロンとしての応用2017
- Author(s)
  高木淳一
- Organizer
  第３回蛋白質工学研究会ワークショップ「小分子抗体関連技術」
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] プロテアーゼ切断によるHGF活性化の構造的基盤2017
- Author(s)
  高木淳一
- Organizer
  金沢大学がん進展制御研究所　共同利用・共同研究拠点シンポジウム
- Place of Presentation
  金沢大学（石川県、金沢市）
- Year and Date
  2017-02-14
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation.2017
- Author(s)
  高木淳一
- Organizer
  2nd IPR/RSC Joint Symposium "PROTEIN STRUCTURE AND FUNCTION”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] 受容体機能における糖鎖の役割を可視化する2017
- Author(s)
  高木淳一
- Organizer
  ConBio2017ワークショップ「化学の視点で拓く糖鎖生物学」
- Invited
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Fv-clasp: An artificially designed small antibody fragment to aid protein crystallization.2017
- Author(s)
  高木淳一
- Organizer
  The 3rd Trilateral Workshop for Frontier Protein Studies
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01420
[Presentation] Fv-clasp化抗体の結晶化シャペロンとしての有用性2016
- Author(s)
  高木淳一
- Organizer
  蛋白研セミナー「抗体創薬の最前線：バイオ医薬品開発の鍵となる分子設計技術」
- Place of Presentation
  九州大学（福岡県、福岡市）
- Year and Date
  2016-11-01
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Understanding the signal transduction mechanism of single-pass membrane receptors via structural analysis2016
- Author(s)
  高木淳一
- Organizer
  第89回日本生化学会大会シンポジウム「Making the most out of structures -Critical role of structural information in modern life science research-」
- Place of Presentation
  仙台国際会議場（宮城県、仙台市）
- Year and Date
  2016-09-27
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Antibodies and macrocyclic peptide binders to aid protein crystallization, receptor functional analysis, and lead discovery.2016
- Author(s)
  Junichi Takagi
- Organizer
  Program in Cellular and Melecular Medicine Seminar, Boston Children’s Hospital / Harvard Medical School
- Place of Presentation
  Boston, USA
- Year and Date
  2016-08-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 新規エピトープタグ開発と分子イメージングへの応用2016
- Author(s)
  高木淳一
- Organizer
  第370回CBI学会研究講演会「分子イメージングと創薬」
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2016-03-03
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] The “PA-tag toolbox”: Purification, detection, and biophysical manipulation of high-value target proteins.2016
- Author(s)
  Junichi Takagi
- Organizer
  The Bioprocessing Summit "Advances in Purification Technologies"
- Place of Presentation
  Westin Boston Waterfront, Boston, USA
- Year and Date
  2016-08-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Antibody-based technology to aid structural study of cell surface receptors.2016
- Author(s)
  Junichi Takagi
- Organizer
  Department Seminar, Langone Medical Center, New York University
- Place of Presentation
  New York, USA
- Year and Date
  2016-08-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 難溶性分泌タンパク質Wnt3aの発現精製・保存法の開発とその再生医療へのインパクト2016
- Author(s)
  高木淳一
- Organizer
  第16回日本蛋白質科学会年会　ワークショップ「最新の蛋白質科学を支えるサンプル調製」
- Place of Presentation
  福岡国際センター（福岡県、福岡市）
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Revisiting the structure-activity relationship of semaphorin 3A2016
- Author(s)
  高木淳一
- Organizer
  第89回日本薬理学会年会シンポジウム「創薬ターゲットとしてのセマフォリン」
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 脳内アミロイドペプチド受容体sorLAの立体構造2015
- Author(s)
  高木淳一
- Organizer
  第三回物構研サイエンスフェスタ
- Place of Presentation
  エポカルつくば
- Year and Date
  2015-03-17
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] ヒト疾患関連受容体の構造生物学研究における高品質タンパク質生産技術の重要性－「技術開発」と「基礎研究」は車の両輪－2015
- Author(s)
  高木淳一
- Organizer
  創薬等PF特別セミナー
- Place of Presentation
  東北大学
- Year and Date
  2015-01-16
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Use of custom-made epitope tagging system to facilitate structural biology on mammalian receptors,2015
- Author(s)
  高木淳一
- Organizer
  The First Trilateral Workshop for Frontier Protein Studies
- Place of Presentation
  北京（中国）
- Year and Date
  2015-04-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] A versatile protein tagging system for recombinant protein production, isolation, and detection in mammalian cells.2015
- Author(s)
  高木淳一
- Organizer
  HUPO 2015　Wako Pure Chemical Industries, Ltd. Industry Seminar
- Place of Presentation
  バンクーバー（カナダ）
- Year and Date
  2015-09-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 抗ペプチド抗体を用いたカスタムアフィニティータグシステムの開発とその応用2015
- Author(s)
  高木淳一
- Organizer
  第25回WSフォーラム「蛋白質・ペプチド研究の現状と展望」
- Place of Presentation
  九州大学（福岡県福岡市）
- Year and Date
  2015-11-21
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 創薬ターゲットの高品質生産の技術と応用2015
- Author(s)
  高木淳一
- Organizer
  PDIS最先端セミナー「創薬につなぐ日本の創薬基盤技術」
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2015-02-04
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 高難度創薬ターゲット蛋白質の生産技術革新とそのインパクト2015
- Author(s)
  高木淳一
- Organizer
  BMB2015ワークショップ「分子生物学と構造生命科学による創薬への挑戦」
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 糖鎖工学・タンパク質工学を駆使して高付加価値抗体を創成する！2015
- Author(s)
  高木淳一
- Organizer
  第3回創薬等支援技術基盤プラットフォーム公開シンポジウム
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Boosting the protein production pipeline by the use of custom-made epitope tagging system.2015
- Author(s)
  高木淳一
- Organizer
  WINTech 2015 “Innovation by Synergy of Computational & Synchrotron Radiation Sciences"
- Place of Presentation
  神戸
- Year and Date
  2015-03-12
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 創薬ターゲット蛋白質の生産におけるカスタムアフィニティータグシステム利用の威力2014
- Author(s)
  高木淳一
- Organizer
  第14回日本蛋白質科学会年会　ランチョンセミナー
- Place of Presentation
  ワークピア横浜/横浜産貿ホールマリネリア
- Year and Date
  2014-06-26
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Boosting the protein production pipeline by the use ofcustom-made epitope tag system2014
- Author(s)
  Takagi J
- Organizer
  IPR Seminar"Antibody Design, Modeling and Applications"
- Place of Presentation
  IPR, Osaka University(大阪)
- Year and Date
  2014-01-15
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Immunological tools to aid recombinant protein production and analysis2014
- Author(s)
  高木淳一
- Organizer
  第43回日本免疫学会学術集会　テクニカルセミナー
- Place of Presentation
  京都国際会館
- Year and Date
  2014-12-10
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Use of custom-made epitope tagging system to facilitate receptor structural biology.2014
- Author(s)
  Junichi Takagi
- Organizer
  Cold Spring Harbor Asia Conference (Mechanism of Transmembrane Signaling).
- Place of Presentation
  Suzhou, China
- Year and Date
  2014-10-28
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 創薬ターゲット蛋白質の生産におけるカスタムアフィニティータグシステム利用の威力2014
- Author(s)
  高木淳一
- Organizer
  第37回日本分子生物学会年会　バイオテクノロジーセミナー
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Structural analysis can lead to a discovery of novel biological function -a case with neuronal lipoprotein receptor sorLA-2014
- Author(s)
  Junichi Takagi
- Organizer
  Seminar on Structural Neuroscience
- Place of Presentation
  Peking University, China
- Year and Date
  2014-10-31
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 創薬ターゲットの高品質生産を可能にする技術革新2014
- Author(s)
  高木淳一
- Organizer
  大阪大学未来戦略機構シンポジウム「アカデミア基盤研究から未来創薬へ」
- Place of Presentation
  東京学士会館(東京)
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Multi-faceted approach to analyze structure and function of integrins.2013
- Author(s)
  Takagi, J
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (USA)
- Year and Date
  2013-02-14
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 創薬関連分子の構造生物学の最前線2013
- Author(s)
  高木淳一
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  千里ライフサイエンスセンター(大阪)
- Year and Date
  2013-10-16
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Atomic model building from low resolution electron microscope images of integrin2013
- Author(s)
  松本淳、岩崎憲治、高木淳一
- Organizer
  Biophysical Society, 57th Annual Meeting
- Place of Presentation
  Philadelphia,USA.
- Data Source
  KAKENHI-PROJECT-22310079
[Presentation] Superimposition of a crystal structure over EM images2013
- Author(s)
  松本淳、高木淳一、岩崎憲治
- Organizer
  Structural Analysis of Supramolecular Assemblies by Hybrid Methods,KeyStone Symposia Conference,
- Place of Presentation
  Granlibakken Resort, Tahoe City,CA,USA.
- Data Source
  KAKENHI-PROJECT-22310079
[Presentation] Multi-faceted approach to analyze structure and function of integrins2013
- Author(s)
  Takagi J
- Organizer
  Gordon Research Conference (Fibronectin, Integrins, & Related molecules)
- Place of Presentation
  Ventura Beach Marriott(USA)
- Year and Date
  2013-02-14
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Atomic model building from low resolution electron microscope images of integrin2013
- Author(s)
  Atsushi Matsumoto, Kenji Iwasaki, Junichi Takagi
- Organizer
  Biophysical Society, 57th Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-22310079
[Presentation] Superimposition ofa crystal structure over EM images2013
- Author(s)
  Atsushi Matsumoto, Junichi Takagi, Kenji Iwasaki
- Organizer
  Structural Analysis of Supramolecular Assemblies by Hybrid Methods,KeyStone Symposia Conference, Granlibakken Resort
- Place of Presentation
  Tahoe City, Calfornia, USA
- Data Source
  KAKENHI-PROJECT-22310079
[Presentation] Multi-faceted approach to analyze structure and function of integrins2013
- Author(s)
  Junichi Takagi
- Organizer
  Gordon Research Conference (Fibronectin, Integrins, Related molecules)
- Place of Presentation
  Ventura Beach Marriott, USA
- Year and Date
  2013-02-14
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 免疫学研究における構造生物学のインパクト2012
- Author(s)
  高木淳一
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2012-12-07
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 蛋白質の立体構造から理解する細胞外シグナル授受のしくみ2012
- Author(s)
  高木淳一
- Organizer
  第12回日本抗加齢医学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2012-06-24
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] 蛋白質の立体構造から理解する細胞外シグナル授受のしくみ2012
- Author(s)
  高木淳一
- Organizer
  第12回日本抗加齢医学会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2012-06-24
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Wnt共受容体LRP6 の電子顕微鏡単粒子解析2012
- Author(s)
  的場京子,三原恵美子,SamuelThompson,岩崎憲治,高木淳一
- Organizer
  第12回日本蛋白質科学会年会,名古屋国際会議場
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22310079
[Presentation] Higher-order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin2012
- Author(s)
  Takagi J
- Organizer
  第35回分子生物学会大会
- Place of Presentation
  福岡国際会議場(福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] "構造神経科学のすすめ"−立体構造情報を使いこなすクールなニューロサイエンティストになろう−2012
- Author(s)
  高木淳一
- Organizer
  第35回日本神経科学会大会
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] 免疫学研究における構造生物学のインパクト2012
- Author(s)
  高木淳一
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Structural basis for peptide ligand recognition by LR11/sorLA Vps10p domain2012
- Author(s)
  Takagi, Junichi
- Organizer
  Keystone Symposia "ApoE, Alzheimer's and Lipoprotein Biology"
- Place of Presentation
  Keystone Resort, CO, USA(招待講演)
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Wnt共受容体LRP6の電子顕微鏡単粒子解析2012
- Author(s)
  的場京子，三原恵美子，Samuel Thompson,岩崎憲治，高木淳一
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-22310079
[Presentation] Correlation technology to fill the gap between X-ray crystallography and microscopic imaging2012
- Author(s)
  Takagi J
- Organizer
  International Integrin Signaling Meeting
- Place of Presentation
  Universitatszentrum Obergurgl, Tirol (Austria)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Correlation technology to fill the gap between X-ray crystallography and microscopic imaging2012
- Author(s)
  Junichi Takagi
- Organizer
  "International Integrin Signaling Meeting"
- Place of Presentation
  Universitaetszentrum Obergurgl, Tirol - Austria
- Year and Date
  2012-09-16
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Higher-order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin2012
- Author(s)
  Junichi Takagi
- Organizer
  第35回日本分子生物学会大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-13
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Structural basis for peptide ligand recognition by LR11/sorLA Vps10p domain2012
- Author(s)
  Takagi, J
- Organizer
  Keystone Symposia "ApoE, Alzheimer's and Lipoprotein Biology"
- Place of Presentation
  Key Stone (USA)
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] “構造神経科学”のすすめ－立体構造情報を使いこなすクールなニューロサイエンティストになろう－2012
- Author(s)
  高木淳一
- Organizer
  第35回日本神経科学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-09-21
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] PPI阻害物質探索のためのprotein-based screening2012
- Author(s)
  高木淳一
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Structural basis for peptide ligand recognition by LR11/sorLA Vps10p domain2012
- Author(s)
  Takagi, Junichi
- Organizer
  Keystone Symposia "ApoE, Alzheimer's and Lipoprotein Biology"
- Place of Presentation
  Keystone Resort, CO, USA(招待講演)
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] ソーティング受容体LR11の持つ"弱くて特異性の低い2011
- Author(s)
  高木淳一
- Organizer
  相互作用の秘密、第2回「神経科学と構造生物学の融合」セミナー
- Place of Presentation
  岡崎
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Structural basis for semaphorin signaling through the plexin receptor2011
- Author(s)
  Takagi, Junichi
- Organizer
  The 9th Taiwan-JapanJoint Seminar on Crystallography
- Place of Presentation
  Taiwan National University, Taiwan(招待講演)
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 神経シナプス接着複合体のマルチモード構造解析2011
- Author(s)
  高木、淳一
- Organizer
  日本蛋白質科学会第11回年会シンポジウム「生命機能を原子分子レベルで探る-細胞システムレベルでの蛋白質科学をめざして-」
- Place of Presentation
  ホテル阪急エキスポパーク(招待講演)
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 神経シナプスにおける接着複合体の準安定な二次元クラスター形成2011
- Author(s)
  高木、淳一
- Organizer
  新学術領域「過渡的複合体」公開シンポジウム
- Place of Presentation
  東京大学薬学部(招待講演)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Structural basis for semaphorin signaling through the plexin receptor2011
- Author(s)
  Takagi, Junichi
- Organizer
  The 9th Taiwan-JapanJoint Seminar on Crystallography
- Place of Presentation
  Taiwan National University, Taiwan(招待講演)
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 神経シナプスにおける接着複合体の準安定な二次元クラスター形成2011
- Author(s)
  高木、淳一
- Organizer
  新学術領域「過渡的複合体」公開シンポジウム
- Place of Presentation
  東京大学薬学部(招待講演)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Structural analyses of b1 integrins by means of electron microscopy and X-ray crystallography2011
- Author(s)
  Takagi, Junichi
- Organizer
  Gordon Research Conference (Fibronectin, Integrins & Related Molecules)
- Place of Presentation
  Ill Ciocco, Italy(招待講演)
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] フィブロネクチン受容体(インテグリンα5β1)の立体構造2011
- Author(s)
  高木、淳一
- Organizer
  第84回日本生化学会大会シンポジウム"蛋白質の高分解能構造と細胞機能発現のメカニズム"
- Place of Presentation
  京都国際会議場(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Structural analyses of b1 integrins by means of electron microscopy and X-ray crystallography2011
- Author(s)
  Takagi, Junichi
- Organizer
  Gordon Research Conference (Fibronectin, Integrins & Related Molecules)
- Place of Presentation
  Ill Ciocco, Italy(招待講演)
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 脳の層構造形成を制御するリーリンシグナルの分子機構2011
- Author(s)
  禾晃和、高木淳一, 他
- Organizer
  蛋白質研究所セミナー・細胞表面受容体と細胞内輸送
- Place of Presentation
  大阪大学蛋白質研究所(招待講演)
- Year and Date
  2011-01-12
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Structural basis for semaphorin signaling through the plexin receptor2011
- Author(s)
  Takagi, Junichi
- Organizer
  Research Seminar at IRCC
- Place of Presentation
  Torino, Italy(招待講演)
- Year and Date
  2011-05-06
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] セマフォリンシグナルを伝達するプレキシン受容体活性化の構造的基盤2011
- Author(s)
  高木淳一
- Organizer
  平成23年度細胞外環境シンポジウム
- Place of Presentation
  京都大学芝蘭会館(招待講演)
- Year and Date
  2011-02-16
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Structural basis for semaphorin signaling through the plexin receptor2011
- Author(s)
  Takagi, Junichi
- Organizer
  Research Seminar at IRCC
- Place of Presentation
  Torino, Italy(招待講演)
- Year and Date
  2011-05-06
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] ソーティング受容体LR11の持つ"弱くて特異性の低い"相互作用の秘密2011
- Author(s)
  高木、淳一
- Organizer
  第2回「神経科学と構造生物学の融合」セミナー
- Place of Presentation
  岡崎コンファレンスセンター(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] フィブロネクチン受容体(インテグリンα5β1)の立体構造2011
- Author(s)
  高木、淳一
- Organizer
  第84回日本生化学会大会シンポジウム"蛋白質の高分解能構造と細胞機能発現のメカニズム"
- Place of Presentation
  京都国際会議場(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 神経シナプス接着複合体のマルチモード構造解析2011
- Author(s)
  高木、淳一
- Organizer
  日本蛋白質科学会第11回年会シンポジウム「生命機能を原子分子レベルで探る-細胞システムレベルでの蛋白質科学をめざして-」
- Place of Presentation
  ホテル阪急エキスポパーク(招待講演)
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] セマフォリンシグナルを伝達するプレキシン受容体活性化の構造的基盤2011
- Author(s)
  高木淳一
- Organizer
  平成23年度細胞外環境シンポジウム
- Place of Presentation
  京都大学芝蘭会館(招待講演)
- Year and Date
  2011-02-16
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] ソーティング受容体LR11の持つ"弱くて特異性の低い"相互作用の秘密2011
- Author(s)
  高木、淳一
- Organizer
  第2回「神経科学と構造生物学の融合」セミナー
- Place of Presentation
  岡崎コンファレンスセンター(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Structural basis for semaphorin signaling through the plexin receptor.2010
- Author(s)
  Takagi, Junichi
- Organizer
  International GCOE Symposium
- Place of Presentation
  Hyogo, Japan(招待講演)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Cutinase融合タンパク質を用いた部位特異的、共有結合的、一段階分子標識法の開発2010
- Author(s)
  松永幸子、高木淳一, 他
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Utilization of acovalent probe and genetically-coded probe-acceptor in a dual-purpose labeling system for light and electron microscopy2010
- Author(s)
  Matsunaga, Y., Takagi, J., et al
- Organizer
  17th International Microscopy Congress
- Place of Presentation
  Windsor Barra Convention Center, Rio de Janeiro,(ブラジル)
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Ligand binding mechanism of lipoprotein receptor family proteins revealed by three-dimensional structure analyses.2010
- Author(s)
  Takagi, Junichi
- Organizer
  Gordon Research Conference (Lipoproteinmetabolism)
- Place of Presentation
  Waterville Valley, (米国)(招待講演)
- Year and Date
  2010-06-23
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Combination of Correlative Light-Electron Microscopy and X-ray Crystal lography Revealed a Unique Trans-Synaptic Adhesion Architecture.2010
- Author(s)
  Takagi, Junichi
- Organizer
  The 2010 Asian Crystallographic Association Conference (AsCA2010)
- Place of Presentation
  Busan,(韓国)(招待講演)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Structural and functional analysis of LR11 Vps10p domain2010
- Author(s)
  Nakata, Z., Takagi, J., et al
- Organizer
  American Crystallographic Association
- Place of Presentation
  Sheraton Chicago Hotel & Towers(米国)
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 遺伝子導入型プローブによる分子標識2010
- Author(s)
  松永幸子、高木淳一, 他
- Organizer
  日本顕微鏡学会第66回学術講演会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Tags for easy detection, purification, and soluble expression of mammalian extracellular proteins2010
- Author(s)
  Takagi, Junichi
- Organizer
  The Bioprocessing Summit, "Affinity Tag Protein Purification"
- Place of Presentation
  Boston Marriott Long Wharf, Boston,(米国)(招待講演)
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 神経シナプス接着機構の解明-原子から細胞まで-2010
- Author(s)
  岩崎憲治、高木淳一, 他
- Organizer
  日本顕微鏡学会第66回学術講演会
- Place of Presentation
  名古屋国際会議場(招待講演)
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Single molecule studies on structure and function of photoactivated adenylyl cyclase (PAC), a sensor for photomovement in Euglena2010
- Author(s)
  岩崎憲治、高木淳一, 他
- Organizer
  Gordon Research Conference, Photosensory Receptors & Signal Transduction
- Place of Presentation
  Lucca(Barga),(イタリア)(招待講演)
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 遺伝子導入型プローブによる分子標識2010
- Author(s)
  松永幸子, 高木淳一
- Organizer
  日本顕微鏡学会第66回学術講演会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 大腸菌での可溶性発現と簡便な精製を可能にするFATTタグ2010
- Author(s)
  田畑早苗、高木淳一, 他
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 大腸菌での可溶性発現と簡便な精製を可能にするFATTタグ2010
- Author(s)
  田畑早苗, 高木淳一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Combination of Correlative Light-Electron Microscopy and X-ray Crystallography Revealed a Unique Trans-Synaptic Adhesion Architecture.2010
- Author(s)
  Takagi, Junichi
- Organizer
  The 2010 Asian Crystallographic Association Conference(AsCA2010)
- Place of Presentation
  Busan, (韓国)(招待講演)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Tags for easy detection, purification, and soluble expression of mammalian extracellular proteins2010
- Author(s)
  Takagi, Junichi
- Organizer
  The Bioprocessing Summit, "Affinity Tag Protein Purification"
- Place of Presentation
  Boston Marriott Long Wharf, Boston, (米国)(招待講演)
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Structural and functional analysis of LR11 Vps10p domain2010
- Author(s)
  Nakata, Z., Takagi, J. et al
- Organizer
  American Crystallographic Association
- Place of Presentation
  Chicago(USA)
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Structural basis for semaphorin signaling through the plexin receptor.2010
- Author(s)
  Takagi, Junichi
- Organizer
  International GCOE Symposium
- Place of Presentation
  Hyogo, Japan(招待講演)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Utilization of a covalent probe and genetically-coded probe-acceptor in adual-purpose labeling system for light and electron microscopy2010
- Author(s)
  Matsunaga, Y., Takagi, J., et al
- Organizer
  17th International Microscopy Congress
- Place of Presentation
  Windsor Barra Convention Center, Rio de Janeiro, (ブラジル)
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Structural and functional analysis of LR11 Vps10p domain2010
- Author(s)
  Nakata, Z., Takagi, J., et al
- Organizer
  American Crystallographic Association
- Place of Presentation
  Sheraton Chicago Hotel & Towers(米国)
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] 光一電子相関顕微鏡観察(CLEM)を用いた細胞間超分子構造の解明2010
- Author(s)
  田中宏樹, 高木淳一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 抗原ペプチド結合前後のモノクローナル抗体P20.1の立体構璋2010
- Author(s)
  寒川剛, 高木淳一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 抗原ペプチド結合前後のモノクローナル抗体P20.1の立体構造2010
- Author(s)
  寒川剛、高木淳一, 他
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Cutinase融合タンパク質を用いた部位特異的、共有結合的、一段階分子標識法の開発2010
- Author(s)
  松永幸子, 高木淳一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 光-電子相関顕微鏡観察(CLEM)を用いた細胞間超分子構造の解明2010
- Author(s)
  田中宏樹、高木淳一, 他
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Ligand binding mechanism of lipoprotein receptor family proteins revealed by three-dimensional structure analyses.2010
- Author(s)
  Takagi, Junichi
- Organizer
  Gordon Research Conference (Lipoprotein metabolism)
- Place of Presentation
  Waterville Valley,(米国)(招待講演)
- Year and Date
  2010-06-23
- Data Source
  KAKENHI-PUBLICLY-22121513
[Presentation] Crystal structure of synaptic adhesion complex; insights into the molecular assembly at the synaptic membrane2009
- Author(s)
  Takagi, J.
- Organizer
  23rd Symposium of The Protein Society
- Place of Presentation
  Boston(USA)
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Affinity tag peptide with a built-in TEV protease recognition sequence2009
- Author(s)
  Takagi, Junichi
- Organizer
  The Bioprocessing Summit
- Place of Presentation
  Boston, Royal Sonesta Hotel (米国)
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] シナプス間接着分子Neuroligin/Neurexin複合体の構造から見えるシナプス間隙の真の姿2009
- Author(s)
  高木、淳一
- Organizer
  第5回プロテオミクス・構造生物学講演会
- Place of Presentation
  学術総合センター
- Year and Date
  2009-11-22
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Novel affinity tag system using structurally defined antibody-tag interaction-Application to single-step protein purification-2009
- Author(s)
  Takagi, Junichi
- Organizer
  PepTalk2009
- Place of Presentation
  San Diego, Hotel del Coronado
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Crystal structure of synaptic adhesion complex ; insights into the molecular assembly at the synaptic membrane2009
- Author(s)
  Takagi, Junichi
- Organizer
  23rd Symposium of The Protein Society
- Place of Presentation
  Boston Marriott Copley Place, Boston (米国)
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] シナプス間接着分子Neuroligin/Neurexin複合体の構造から見えるシナプス間隙の真の姿2009
- Author(s)
  高木淳一
- Organizer
  第5回プロテオミクス・構造生物学講演会
- Place of Presentation
  東京
- Year and Date
  2009-11-22
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Development of a novel affinity tag system for the next generation structural biology2008
- Author(s)
  Takagi, Junichi
- Organizer
  2nd Pacific-Rim International Conference on Protein Science
- Place of Presentation
  Cairns Convention Center, Cairns. Australia
- Year and Date
  2008-06-22
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] シナプス問接着分子Neurexin/Neuroligin複合体の構造から見えるシナプス間隙の真の姿2008
- Author(s)
  高木、淳一
- Organizer
  学振第169委員会第27会研究会
- Place of Presentation
  京都大学百周年時計台記念館
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 脳の層構造形成を司る細胞外因子リーリンの結晶構造と受容体による認識機構2007
- Author(s)
  高木、淳一
- Organizer
  日本分子生物学会・日本生化学会合同シンポジウム (BMB2007)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 脳の層構造形成を司る細胞外因子リーリンの結品構造と受容体による認識機構2007
- Author(s)
  高木淳一
- Organizer
  日本分子生物学会・日本生化学会合同シンポジウム(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Challenges in structural analysis of extracellular protein complexes2007
- Author(s)
  Takagi, Junichi
- Organizer
  2nd Intemational Symposium on Diffraction Structural Biology 2007
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Challenges in structural analysis of extracellular protein complexes2007
- Author(s)
  Takagi, J
- Organizer
  2nd International Symposium on Diffraction Structural Biology 2007
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Presentation] Challenges in structural analysis of extracellular protein complexes2007
- Author(s)
  Takagi.
- Organizer
  2nd International Symposium on Diffraction Structural Biology 2007
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Challenges in structural analysis of extracellular protein complexes2007
- Author(s)
  Takagi, Junichi
- Organizer
  2nd International Symposium on Diffraction Structura I Biology 2007
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Presentation] Challenges in structural analysis of extracellular protein complexes2007
- Author(s)
  Takagi, Junichi
- Organizer
  2nd Intemational Symposium on Diffraction Structura I Biology 2007
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-16207006
[Presentation] 3D structure of reelin protein and its recognition mechanism by receptors2007
- Author(s)
  Takagi, J
- Organizer
  BMB 2007 Symposium
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Presentation] 脳の層構造形成を司る細胞外因子リーリンの結晶構造と受容体による認識機構2007
- Author(s)
  高木、淳一
- Organizer
  日本分子生物学会・日本生化学会合同シンポジウム(BMB2007)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16207006
[Presentation] Higher-order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin
- Author(s)
  Junichi Takagi
- Organizer
  第35回日本分子生物学会大会
- Place of Presentation
  福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Resolution, dynamics, and heterogeneity -In what detail do we need to know protein structures for answering biological questions?
- Author(s)
  Junichi Takagi
- Organizer
  Gordon Research Conference (X-ray Science)
- Place of Presentation
  Stonehill Colledge, USA
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Analyzing higher-order architecture of synaptic adhesion machinery: Correlation technologies to fill the gap between different imaging methods
- Author(s)
  Junichi Takagi
- Organizer
  11th International Conference on Biology and Synchrotron Radiation
- Place of Presentation
  Humberg, Germany
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Correlation technology to fill the gap between X-ray crystallography and microscopic imaging
- Author(s)
  Junichi Takagi
- Organizer
  "International Integrin Signaling Meeting"
- Place of Presentation
  Universitaetszentrum Obergurgl, Tirol - Austria
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] PPI阻害物質探索のためのprotein-based screening
- Author(s)
  高木淳一
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 蛋白質の立体構造から理解する細胞外シグナル授受のしくみ
- Author(s)
  高木淳一
- Organizer
  第12回日本抗加齢医学会
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] アミロイドクリアランス受容体sorLAの構造
- Author(s)
  高木　淳一
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  千里ライフサイエンスセンター（大阪府）
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 創薬ターゲットの高品質生産を可能にする技術革新
- Author(s)
  高木　淳一
- Organizer
  大阪大学未来戦略機構創薬シンポジウム「アカデミア基盤研究から未来創薬へ」
- Place of Presentation
  東京　学士会館（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] 創薬関連分子の構造生物学の最前線
- Author(s)
  高木　淳一
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  千里ライフサイエンスセンター（大阪府）
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Multi-faceted approach to analyze structure and function of integrins
- Author(s)
  Junichi Takagi
- Organizer
  Gordon Research Conference (Fibronectin, Integrins, & Related molecules)
- Place of Presentation
  Ventura Beach Marriott, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 免疫学研究における構造生物学のインパクト
- Author(s)
  高木淳一
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸ポートアイランド
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] “構造神経科学”のすすめ－立体構造情報を使いこなすクールなニューロサイエンティストになろう－
- Author(s)
  高木淳一
- Organizer
  第35回日本神経科学会大会
- Place of Presentation
  名古屋国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] Expanding the Structural Genomics to Structural Life Science: Not just to answer, but to ask new biological questions
- Author(s)
  Junichi Takagi
- Organizer
  International Conference on Structural Genomics 2013 - Structural Life Science
- Place of Presentation
  札幌京王プラザホテル（北海道）
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] 蛋白質の立体構造から理解する細胞外シグナル授受のしくみ
- Author(s)
  高木淳一
- Organizer
  第12回日本抗加齢医学会
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] “構造神経科学”のすすめ－立体構造情報を使いこなすクールなニューロサイエンティストになろう－
- Author(s)
  高木淳一
- Organizer
  第35回日本神経科学会大会
- Place of Presentation
  名古屋国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] アミロイドクリアランス受容体sorLA/LR11の構造
- Author(s)
  高木　淳一
- Organizer
  蛋白研セミナー「第４回神経科学と構造生物学の融合研究会」
- Place of Presentation
  岡崎コンファレンスセンター（愛知県）
- Invited
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Boosting the protein production pipeline by the use ofcustom-made epitope tag　system
- Author(s)
  Junichi Takagi
- Organizer
  IPR Seminar “Antibody Design, Modeling and Applications”
- Place of Presentation
  IPR, Osaka Univ.（大阪府）
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Correlation technology to fill the gap between X-ray crystallography and microscopic imaging
- Author(s)
  Junichi Takagi
- Organizer
  "International Integrin Signaling Meeting"
- Place of Presentation
  Universitaetszentrum Obergurgl, Tirol - Austria
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] PPI阻害物質探索のためのprotein-based screening
- Author(s)
  高木淳一
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Higher-order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin
- Author(s)
  Junichi Takagi
- Organizer
  第35回日本分子生物学会大会
- Place of Presentation
  福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22247010
[Presentation] 免疫学研究における構造生物学のインパクト
- Author(s)
  高木淳一
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸ポートアイランド
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[Presentation] Multi-faceted approach to analyze structure and function of integrins
- Author(s)
  Junichi Takagi
- Organizer
  Gordon Research Conference (Fibronectin, Integrins, & Related molecules)
- Place of Presentation
  Ventura Beach Marriott, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24651260
[]
[]

1. NOGI Terukazu (40379102)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. IWASAKI Kenji (20342751)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
3. SAITO Yuji (30134810)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NAGASAWA Takashi (80281690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SUZUKI Yoko (30179270)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SEHARA Atsuko (60209038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIWAKI Kiyoji (30342827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAGA Yumiko (50221271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YASUI Norihisa (90467514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. TAKAHAMA Yousuke (20183858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SEKIGUCHI Kiyotoshi (50187845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. GU Jianguo (40260369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMADA Masashi (90304055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FUTAKI Sugiko (00403014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 渡邊武 (40028684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 湊長博 (40137716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 宮坂昌之 (50064613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 高田慎治 (60206753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 福井宣規 (60243961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 北郷悠 (60507185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 広瀬茂久 (10134199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 萩原啓実 (90189465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 李紹良 (40252720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. BLEACKLEY Christopher

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TACHIBANA Shinro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MCELHANEY Ro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MCELHANEY Ronald N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. MATANO Mami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. ISHITANI Ryuichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
31. SUGA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. SAKAKIBARA Shuhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. YAMAMOTO Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. YAMASHITA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. BABA Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. ISE Masako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. KATOH Kazutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 片桐晃子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 佐藤拓輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
40. 長江雅倫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
41. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 檜作洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
43. 濡木理

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
44. 松本邦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 有森貴夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 木内泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 南部由希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 潮田亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 武城英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 小亀浩市

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 村山正承

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 明石知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 谷中冴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takagi Junichi 高木 淳一

TAKAGI Junichi 高木 淳一

Research Projects

Research Products

Co-Researchers

Creation of bivalent Fc protein that can control receptor signaling and elucidation of its structural mechanismPrincipal Investigator

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Structural elucidation of Wnt signaling mechanism using unique chemical toolsPrincipal Investigator

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Novel design of AAV capsid by LassoGraft TechnologyPrincipal Investigator

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Re-engineering of AAV particle by "peptide insertion" methodPrincipal Investigator

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Structural mechanism of the Wnt-receptor interactionPrincipal Investigator

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Analysis and Synthesis of Multidimensional Immune Organ Network

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Structural basis for the cell-cell communication at the neuro-immune interfacePrincipal Investigator

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Development of a novel screening system for PPI-targeted drugs using cutinase fusion strategyPrincipal Investigator

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神経シナプスにおける接着複合体の準安定な二次元クラスター形成Principal Investigator

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Structural basis for cell signaling mediated by lipoprotein receptorsPrincipal Investigator

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Development of vitreous ice technique and correlative microscopy to observe biological specimens at a molecular resolution

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アミロイド前駆体蛋白質細胞外ドメインとその機能修飾因子の複合体の構造解析Principal Investigator

Principal Investigator

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Dynamics of extracellular environments

Principal Investigator

Project Period (FY)

Takagi Junichi 高木淳一

TAKAGI Junichi 高木淳一