YUO Akira 湯尾明

Researcher Number	90221663
External Links
Affiliation *help	2010 – 2011 : 独立行政法人国立国際医療研究センター, その他 2011 : 独立行政法人国立国際医療研究センター, 研究所・疾患制御研究部, 部長 2010 : 独立行政法人国立国際医療研究センター, 研究所疾患制御研究部, 部長 2009 : 国立国際医療セ 2009 : Research Institute, International Medical Center of Japan, 血液疾患研究部, 部長 … More
Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology
Keywords	Principal Investigator 急性骨髄性白血病 / 分化 / 形質細胞腫 / EMR1 / 無フィーダー培養 / CD34 / サイトカイン / 細胞内刺激伝達 / チロシンキナーゼ / 機能 … More Except Principal Investigator ホメオボックス遺伝子 / 平滑筋細胞 / 継代可能性 / ノックアウトマウス / 血管内皮細胞 / 無フィーダー培養 / 心筋細胞 / ホメオボックス / bHLH転写因子 / トランスジェニックマウス / 胚様体 / 発生 / カニクイザル / 平面培養 / 心臓 / 胚性幹細胞 / エンドセリン / 神経堤細胞 / VE-cadherin Less

Induction of hematopoietic stem cells from human pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  YUO Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
霊長類ES細胞に由来する血管内皮細胞の増殖機構解析と造血機能評価
- Principal Investigator
  
  佐伯久美子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
霊長類ES細胞からの無フィーダー、無血清培養における血液細胞分化システムの確立Principal Investigator
- Principal Investigator
  
  湯尾明
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
細胞外EGF様反復構造を有する7回膜貫通型ヒト受容体EMR1に関する研究:抗体作成と発現細胞の同定、結合分子とシグナルの検討、並びにリガンドの探索Principal Investigator
- Principal Investigator
  
  湯尾明
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
心血管系の発生分化とその分子機構の解析
- Principal Investigator
  
  矢崎義雄
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Research Institute, International Medical Center of Japan
  The University of Tokyo
骨髄性白血病細胞の分化と細胞内刺激伝達機構Principal Investigator
- Principal Investigator
  
  湯尾明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
インターロイキン6(IL-6)によるヒト多発性骨髄腫細胞の増殖機構の解明Principal Investigator
- Principal Investigator
  
  湯尾明
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
サイトカインによる骨髄性白血病細胞チロシンキナーゼの活性化:患者検体を用いた検討Principal Investigator
- Principal Investigator
  
  湯尾明
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan

All 2011 2009 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] ラミニンによるGM-CSFレセプターのシグナル伝達の調節。Annual Review 血液20052005
- Author(s)
  湯尾明
- Total Pages
  308
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-16659260
[Book] Pelger-Huet anomalyにおける遺伝子異常 Annual Review血液20042004
- Author(s)
  湯尾明(高久史麿, 溝口秀昭, 小宮山淳, 坂田洋一, 金倉譲編)
- Total Pages
  308
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] Early senescence is not an inevitable fate of human induced pluripotent stem-derived cells2011
- Author(s)
  Gokoh M, Nakamura N, Matsuyama S, Nishio M, Akutsu H, Umezawa A, Yasuda K, Yuo A, Saeki K
- Journal Title
  
  Cellular Reprogram
  
  Volume : 13 Pages : 361-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591255, KAKENHI-PROJECT-22390312, KAKENHI-PROJECT-22591053
[Journal Article] ヒトES細胞からの造血細胞への分化-好中球産生を中心として-2009
- Author(s)
  佐伯久美子、湯尾明
- Journal Title
  
  医学のあゆみ 229
  
  Pages : 704-710
- Data Source
  KAKENHI-PROJECT-21591255
[Journal Article] High efficiency production of subculturable vascular endothelial cells from feeder-free human embryonic stem cells without cell-sorting technique2009
- Author(s)
  Nakahara M, Yuo A, 他
- Journal Title
  
  Cloning Stem Cells 11
  
  Pages : 509-522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591255
[Journal Article] The protein expression profile of cynomolgus monkey embryonicstem cells in two-dimensional gel electrophoresis:a successful identification of multiple proteins using human databases.2007
- Author(s)
  Nakahara M, Saeki K, Yogiashi Y, Kimura A, Horiuchi A, Nakamura N, Yoneda A, Saeki K, Matsuyama S, Nakamura M, Toda T, Kondo Y, Kaburagi Y, Yuo A
- Journal Title
  
  Journal of Electrophoresis 51
  
  Pages : 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659288
[Journal Article] Identification of human neutrophils during experimentally induced inflammation in mice with transplanted CD34+ cells from human umbilical cord blood.2006
- Author(s)
  Doshi M, Koyanagi M, Nakahara M, Saeki K, Saeki K, Yuo A
- Journal Title
  
  International Journal of Hematology 84
  
  Pages : 231-237
- Data Source
  KAKENHI-PROJECT-18659288
[Journal Article] Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells.2006
- Author(s)
  Yasugi E, Horiuchi A, Uemura I, Okuma E, Nakatsu M, Saeki K, Kamisaka Y, Kagechika H, Yasuda K, Yuo A
- Journal Title
  
  Development, Growth ＆ Differentiation 48
  
  Pages : 177-188
- Data Source
  KAKENHI-PROJECT-18659288
[Journal Article] Synergistic effects of dehydro-epiandrosterone and retinoic acid on granulocytic differentiation of human promyelocytic NB4 cells.2005
- Author(s)
  Nakatsu M, Doshi M, Saeki K, Yuo A
- Journal Title
  
  Int J Hematol 81
  
  Pages : 32-38
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] ATRAとアポトーシス2005
- Author(s)
  湯尾明
- Journal Title
  
  Medical Technology 33
  
  Pages : 127-128
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] Synergistic effects of dehydroepiandrosterone and retinoic acid on granulocytic differentiation of human promyelocytic NB4 cells.2005
- Author(s)
  Nakatsu M, Doshi M, Saeki K, Yuo A
- Journal Title
  
  Int J Hematol 81
  
  Pages : 32-38
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] Proteomic analysis on insulin signaling in human hematopoietic cells : identification of CLIC1 and SRp20 as novel downstream effectors of insulin.2005
- Author(s)
  Saeki K, Yasugi E, Okuma E, Breit SN, Nakamura M, Toda T, Kaburagi Y, Yuo A
- Journal Title
  
  Am J Physiol Endocrinol Metab 289
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] Structural requirement of dolichyl phosphate as an apoptosis inducer.2005
- Author(s)
  Horiuchi A, Yasugi E, Yuo A
- Journal Title
  
  J Oleo Science 54
  
  Pages : 341-346
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein.2005
- Author(s)
  Yano T, Itoh Y, Kubota T, Sendo T, Koyama T, Fujita T, Saeki K, Yuo A, Oishi R
- Journal Title
  
  Am J Pathol 166
  
  Pages : 1333-1342
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] ATRAとアポトーシス。2005
- Author(s)
  湯尾明
- Journal Title
  
  Medical Technology 33
  
  Pages : 127-128
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] ATRAによる顆粒球のアポトーシスの分子機構2004
- Author(s)
  湯尾明
- Journal Title
  
  臨床免疫 41
  
  Pages : 148-152
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] Brap2 functions as a cytoplasmic retention protein for p21 during monocytic differentiation.2004
- Author(s)
  Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S
- Journal Title
  
  Mol Cell Biol 24
  
  Pages : 8236-8243
- Data Source
  KAKENHI-PROJECT-16659260
[Journal Article] NK-κB依存性リンパ球活性化におけるパラカスパーゼの役割2004
- Author(s)
  湯尾明
- Journal Title
  
  BIO clinica 19
  
  Pages : 1027-1031
- Data Source
  KAKENHI-PROJECT-16659260
[Presentation] 無フィーダー・無血清環境でのヒトES細胞からの赤血球および造血ストロマ細胞の作製2011
- Author(s)
  西尾美和子、中村直子、松山さと子、湯尾明、佐伯久美子
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591255
[Presentation] Directed differentiation of human pluripotent stem cells into brown adipocyte-like cells2011
- Author(s)
  Nishio M, Nakahara M, Yuo A, Saeki K
- Organizer
  The 4th Annual Congress of Regenerative Medicine & Stem Cell
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-21591255
[Presentation] 無フィーダー・無血清環境でのヒトES細胞からの赤血球および造血ストロマ細胞の作製2011
- Author(s)
  西尾美和子、中村直子、松山さと子、湯尾明、佐伯久美子
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  東京
- Year and Date
  2011-03-01
- Data Source
  KAKENHI-PROJECT-21591255
[Presentation] A feeder-free hematopoietic differentiation of human induced pluripotent stem cells : towards a provision of rejection-free neutrophils for granulocyte transfusion therapy2009
- Author(s)
  Saeki K, YUo A, 他
- Organizer
  7th annual meeting of International Society for Stem Cell Research
- Place of Presentation
  スペイン、バルセロナ
- Data Source
  KAKENHI-PROJECT-21591255
[Presentation] 霊長類(サル、ヒト)ES細胞からの無フィーダー培養による高効率な血管内皮細胞分化誘導法の開発-各サイトカインの役割の検討及びin vivoでの機能評価-。2007
- Author(s)
  中原正子、過足芳子、佐伯久美子、佐伯晃一、中村直子、松山さと子、米田麻子、小柳真、近藤靖、末盛博文、中辻憲夫、湯尾明
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18659288

1. SAEKI Kumiko (80322717)

# of Collaborated Projects : 3results

# of Collaborated Products : 14results
2. NISHIO Miwako (30623318)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
3. 矢崎義雄 (20101090)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. 栗原裕基 (20221947)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 小室一成 (30260483)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 山崎力 (60251245)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 本田浩章 (40245064)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 塩島一朗

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. AKUTSU Hidenori

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

YUO Akira 湯尾 明

Research Projects

Research Products

Co-Researchers

Induction of hematopoietic stem cells from human pluripotent stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

霊長類ES細胞に由来する血管内皮細胞の増殖機構解析と造血機能評価

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

霊長類ES細胞からの無フィーダー、無血清培養における血液細胞分化システムの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞外EGF様反復構造を有する7回膜貫通型ヒト受容体EMR1に関する研究:抗体作成と発現細胞の同定、結合分子とシグナルの検討、並びにリガンドの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心血管系の発生分化とその分子機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

骨髄性白血病細胞の分化と細胞内刺激伝達機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インターロイキン6(IL-6)によるヒト多発性骨髄腫細胞の増殖機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サイトカインによる骨髄性白血病細胞チロシンキナーゼの活性化:患者検体を用いた検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ラミニンによるGM-CSFレセプターのシグナル伝達の調節。Annual Review 血液20052005

Author(s)

Total Pages

Publisher

Data Source

[Book] Pelger-Huet anomalyにおける遺伝子異常 Annual Review血液20042004

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Early senescence is not an inevitable fate of human induced pluripotent stem-derived cells2011

Author(s)

Journal Title

Data Source

[Journal Article] ヒトES細胞からの造血細胞への分化-好中球産生を中心として-2009

Author(s)

Journal Title

Data Source

[Journal Article] High efficiency production of subculturable vascular endothelial cells from feeder-free human embryonic stem cells without cell-sorting technique2009

Author(s)

Journal Title

Data Source

[Journal Article] The protein expression profile of cynomolgus monkey embryonicstem cells in two-dimensional gel electrophoresis:a successful identification of multiple proteins using human databases.2007

Author(s)

Journal Title

Data Source

[Journal Article] Identification of human neutrophils during experimentally induced inflammation in mice with transplanted CD34+ cells from human umbilical cord blood.2006

Author(s)

Journal Title

YUO Akira 湯尾明