MIZUNO Keiko 水野恵子

Researcher Number	90221803
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2000 – 2006: 横浜市立大学, 医学部, 助手 2004: 横浜市立大学, 医学, 助手 1992 – 1998: YCU Sch. Med. Dept. Mol. Bio. Assistant Professor, 医学部, 助手
Review Section/Research Field	Principal Investigator Cell biology / General medical chemistry / Functional biochemistry Except Principal Investigator General medical chemistry / Biological Sciences / Functional biochemistry / General medical chemistry / Pathological medical chemistry
Keywords	Principal Investigator apoptosis / ASIP / PAR-3 / atypical PKC / 細胞周期 / 限定分解 / protein kinase C / 生化学 / 分子生物学 / プロテインキナーゼC … More / 細胞増殖 / Cell polarity / 細胞極性 / Protein kinase C / lionited proteolsis / limited proteolysis … More Except Principal Investigator プロテインキナーゼC / ジアシルグリセロール / 転写活性化 / ホルボールエステル / PKC関連酵素 / ASIP / PAR-6 / PAR-3 / aPKC / HB-EGF / ATPase / RNA helicase / PIK remated protein kinase / protein kinase / P53 / mRNA surveillance / mRNA degradation / ATPアーゼ / RNAヘリカーゼ / リン脂質キナーゼ / プロテインキナーゼ / p53 / mRNAサーベイランス / mRNA分離 / ナンセンス変異 / ADAM / PKC / protein kinase C / キナーゼ / 上皮 / 極性 / 非対称分裂 / 線虫 / 上皮細胞 / 細胞外ドメイン / メタロプロテアーゼ / ストレス応答 / nonsense mutation / nonsense mutaion / epithelia / cell polarity / Asymmetric division / Lg1 / membrane proteins / extracellular domain / shedding / metaloprotease / がん / 増殖 / 細胞極性 / 膜タンパク質 / 切り出し / TPA-response element / TPA / PKC binding proteins / PKC substrates / tumor promoters / diacylglyverol / phospholipids / Diacylglycerol / Kinase / Transcriptional Activation / Phorbol esters / PKC-related enzymes / Protein kinase C / 上皮組織 / キナ-ゼ / ホルボ-ルエステル / プロテインキナ-ゼC / 乳がん / 胃がん / 前立腺がん / MDCK細胞 / インテグリン / rac / PAK / SEK / JNK / SAPK / マップキナーゼ / DNA合成 / 血清飢餓 / プロテインキナーゼC結合タンパク質 / ホスホリパーゼC / PI3キナーゼ / メタロプロティナーゼ / NFkB / S6キナーゼ Less

Cell Polarity Signaling and Cancer
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Molecular mechanism of mammalian mRNA surveillance
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University
Molecular mechanism of mammalian mRNA surveillance
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University Graduate School of Medical Science
Determination of aPKC substrates in the regulation of cell polarity.Principal Investigator
- Principal Investigator
  
  MIZUNO Keiko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University
Signaling mechanism of epithelial cell-cell attachment and cell polarity.
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
PKCの蛋白質分解による細胞分裂及び細胞死の制御機構の解明Principal Investigator
- Principal Investigator
  
  水野恵子
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Yokohama City University
PKCの蛋白質分解機構の解明とアポトーシスにおける機能解析Principal Investigator
- Principal Investigator
  
  水野恵子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
血管内皮細胞の細胞間相互作用とPKC
- Principal Investigator
  
  大野茂男
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
アポトーシスにおけるPKCδ ε θの限定分解の生理的意義の解明Principal Investigator
- Principal Investigator
  
  水野恵子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University
Manipulation of the interaction between protein kinase C and its specific substrate proteins
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University School of Medicine
細胞接着と細胞増殖におけるC-キナーゼの役割
- Principal Investigator
  
  大野茂男
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
新規キナーゼMUK1,MUK3の関与するキナーゼカスケードの解明
- Principal Investigator
  
  長田真一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
ラット繊維芽細胞3Y1の増殖制御におけるPKC分子種の役割Principal Investigator
- Principal Investigator
  
  水野恵子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Yokohama City University
細胞増殖に関わるPKC分子種の同定とその作用機序の解析Principal Investigator
- Principal Investigator
  
  水野恵子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Yokohama City University
細胞増殖におけるプロテインキナーゼC群の機能の分子生物学的解析
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
Action mechanisms of dominant negative protein kinase C ; identification of PKC binding proteins
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University
Identification and Functional Analysis of Protein Kinase C-Related Gene
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE

All 2009 2006 2004 2003 Other

All Journal Article

[Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.2009
- Author(s)
  Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonmura S, Ohno S
- Journal Title
  
  Journal of Cell Science 122(10)
  
  Pages: 1595-1606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014076
[Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.2009
- Author(s)
  Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S
- Journal Title
  
  J. Cell Science 122(10)
  
  Pages: 1595-1606
- Data Source
  KAKENHI-PROJECT-17014076
[Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells2009
- Author(s)
  Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S
- Journal Title
  
  Journal of Cell Science 122(10)
  
  Pages: 1595-1606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014076
[Journal Article] Lgl mediates apical domain disassembly by suppressing PAR-3/aPKC/PAR-6 complex to orient apical membrane polarity.2006
- Author(s)
  Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S
- Journal Title
  
  J.Cell Science 119
  
  Pages: 2107-2118
- Data Source
  KAKENHI-PROJECT-17014076
[Journal Article] Lgl mediates apical domain disassembly by suppressing PAR-3/aPKC/PAR-6 complex to orient apical membrane polarity.2006
- Author(s)
  Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S
- Journal Title
  
  J. Cell Science 119
  
  Pages: 2107-2118
- Data Source
  KAKENHI-PROJECT-17014076
[Journal Article] aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.2004
- Author(s)
  Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S.
- Journal Title
  
  Curr Biology 14(16)
  
  Pages: 1425-1435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219215
[Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.2003
- Author(s)
  Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, Y., Amano, Y., Ohno, S.
- Journal Title
  
  J. Biol. Chem. 278(33)
  
  Pages: 31240-31250
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219215
[Journal Article] The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression2003
- Author(s)
  Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K-I., Ohno, S.
- Journal Title
  
  Genes to Cells 8
  
  Pages: 311-324
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.2003
- Author(s)
  Mizuno K, Suzuki A, Hirose T, Kitamura K, Kutsuzawa K, Futaki M, Amano Y, Ohnos S
- Journal Title
  
  J.Biol.Chem 278(33)
  
  Pages: 31240-31250
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.2003
- Author(s)
  Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, Y., Futaki, M., Amano, Y., Ohno, S.
- Journal Title
  
  J. Biol. Chem. 278(33)
  
  Pages: 31240-31250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219215
[Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions2003
- Author(s)
  Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, K., Futaki, M., Amano, Y., Ohno, S.
- Journal Title
  
  J. Biol. Chem. 278(33)
  
  Pages: 31240-31250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] The second phase activation of protein kinase Cd at late G1 is required for DNA synthesis in serum-induced cell cycle progression.2003
- Author(s)
  Kitamura K, Mizuno K, Etoh A, Akita Y, Miyamoto A, Nakayama K-I, Ohno S
- Journal Title
  
  Genes to Cells 8
  
  Pages: 311-324
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] ASPP2 Regulates Epithelial Cell Polarity through the PAR Complex.
- Author(s)
  Cong W, Hirose T, Harita Y, YamashitaA, Mizuno K, Hirano H, Ohno S.
- Journal Title
  
  Current Biology (in press)
- Data Source
  KAKENHI-PROJECT-17014076

1. OHNO Shigeo (10142027)

# of Collaborated Projects: 10 results

# of Collaborated Products: 13 results
2. HIRAI Shu-ichi (80228759)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. SUZUKI Atsushi (00264606)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
4. OSADA Shinichi (00244484)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. AKIMOTO Kazunori (70285104)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. HIROSE Tomonori (20381668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 秋田朗子 (40124432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 杉山由樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUNO Keiko 水野 恵子

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Determination of aPKC substrates in the regulation of cell polarity.Principal Investigator

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PKCの蛋白質分解による細胞分裂及び細胞死の制御機構の解明Principal Investigator

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PKCの蛋白質分解機構の解明とアポトーシスにおける機能解析Principal Investigator

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アポトーシスにおけるPKCδ ε θの限定分解の生理的意義の解明Principal Investigator

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ラット繊維芽細胞3Y1の増殖制御におけるPKC分子種の役割Principal Investigator

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細胞増殖に関わるPKC分子種の同定とその作用機序の解析Principal Investigator

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MIZUNO Keiko 水野恵子