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MIZUNO Keiko  水野 恵子

ORCIDConnect your ORCID iD *help
Researcher Number 90221803
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2000 – 2006: 横浜市立大学, 医学部, 助手
2004: 横浜市立大学, 医学, 助手
1992 – 1998: YCU Sch. Med. Dept. Mol. Bio. Assistant Professor, 医学部, 助手
Review Section/Research Field
Principal Investigator
Cell biology / General medical chemistry / Functional biochemistry
Except Principal Investigator
General medical chemistry / Biological Sciences / Functional biochemistry / General medical chemistry / Pathological medical chemistry
Keywords
Principal Investigator
apoptosis / ASIP / PAR-3 / atypical PKC / 細胞周期 / 限定分解 / protein kinase C / 生化学 / 分子生物学 / プロテインキナーゼC … More / 細胞増殖 / Cell polarity / 細胞極性 / Protein kinase C / lionited proteolsis / limited proteolysis … More
Except Principal Investigator
プロテインキナーゼC / ジアシルグリセロール / 転写活性化 / ホルボールエステル / PKC関連酵素 / ASIP / PAR-6 / PAR-3 / aPKC / HB-EGF / ATPase / RNA helicase / PIK remated protein kinase / protein kinase / P53 / mRNA surveillance / mRNA degradation / ATPアーゼ / RNAヘリカーゼ / リン脂質キナーゼ / プロテインキナーゼ / p53 / mRNAサーベイランス / mRNA分離 / ナンセンス変異 / ADAM / PKC / protein kinase C / キナーゼ / 上皮 / 極性 / 非対称分裂 / 線虫 / 上皮細胞 / 細胞外ドメイン / メタロプロテアーゼ / ストレス応答 / nonsense mutation / nonsense mutaion / epithelia / cell polarity / Asymmetric division / Lg1 / membrane proteins / extracellular domain / shedding / metaloprotease / がん / 増殖 / 細胞極性 / 膜タンパク質 / 切り出し / TPA-response element / TPA / PKC binding proteins / PKC substrates / tumor promoters / diacylglyverol / phospholipids / Diacylglycerol / Kinase / Transcriptional Activation / Phorbol esters / PKC-related enzymes / Protein kinase C / 上皮組織 / キナ-ゼ / ホルボ-ルエステル / プロテインキナ-ゼC / 乳がん / 胃がん / 前立腺がん / MDCK細胞 / インテグリン / rac / PAK / SEK / JNK / SAPK / マップキナーゼ / DNA合成 / 血清飢餓 / プロテインキナーゼC結合タンパク質 / ホスホリパーゼC / PI3キナーゼ / メタロプロティナーゼ / NFkB / S6キナーゼ Less
  • Research Projects

    (17 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (8 People)
  •  Cell Polarity Signaling and Cancer

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  Molecular mechanism of mammalian mRNA surveillance

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Yokohama City University
  •  Molecular mechanism of mammalian mRNA surveillance

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Yokohama City University Graduate School of Medical Science
  •  Determination of aPKC substrates in the regulation of cell polarity.Principal Investigator

    • Principal Investigator
      MIZUNO Keiko
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Yokohama City University
  •  Signaling mechanism of epithelial cell-cell attachment and cell polarity.

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  PKCの蛋白質分解による細胞分裂及び細胞死の制御機構の解明Principal Investigator

    • Principal Investigator
      水野 恵子
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Yokohama City University
  •  PKCの蛋白質分解機構の解明とアポトーシスにおける機能解析Principal Investigator

    • Principal Investigator
      水野 恵子
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  血管内皮細胞の細胞間相互作用とPKC

    • Principal Investigator
      大野 茂男
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  アポトーシスにおけるPKCδ ε θの限定分解の生理的意義の解明Principal Investigator

    • Principal Investigator
      水野 恵子
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      Yokohama City University
  •  Manipulation of the interaction between protein kinase C and its specific substrate proteins

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Yokohama City University School of Medicine
  •  細胞接着と細胞増殖におけるC-キナーゼの役割

    • Principal Investigator
      大野 茂男
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  新規キナーゼMUK1,MUK3の関与するキナーゼカスケードの解明

    • Principal Investigator
      長田 真一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  ラット繊維芽細胞3Y1の増殖制御におけるPKC分子種の役割Principal Investigator

    • Principal Investigator
      水野 恵子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Yokohama City University
  •  細胞増殖に関わるPKC分子種の同定とその作用機序の解析Principal Investigator

    • Principal Investigator
      水野 恵子
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Yokohama City University
  •  細胞増殖におけるプロテインキナーゼC群の機能の分子生物学的解析

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  Action mechanisms of dominant negative protein kinase C ; identification of PKC binding proteins

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Yokohama City University
  •  Identification and Functional Analysis of Protein Kinase C-Related Gene

    • Principal Investigator
      OHNO Shigeo
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE

All 2009 2006 2004 2003 Other

All Journal Article

  • [Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.2009

    • Author(s)
      Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonmura S, Ohno S
    • Journal Title

      Journal of Cell Science 122(10)

      Pages: 1595-1606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014076
  • [Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.2009

    • Author(s)
      Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S
    • Journal Title

      J. Cell Science 122(10)

      Pages: 1595-1606

    • Data Source
      KAKENHI-PROJECT-17014076
  • [Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells2009

    • Author(s)
      Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S
    • Journal Title

      Journal of Cell Science 122(10)

      Pages: 1595-1606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014076
  • [Journal Article] Lgl mediates apical domain disassembly by suppressing PAR-3/aPKC/PAR-6 complex to orient apical membrane polarity.2006

    • Author(s)
      Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S
    • Journal Title

      J.Cell Science 119

      Pages: 2107-2118

    • Data Source
      KAKENHI-PROJECT-17014076
  • [Journal Article] Lgl mediates apical domain disassembly by suppressing PAR-3/aPKC/PAR-6 complex to orient apical membrane polarity.2006

    • Author(s)
      Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S
    • Journal Title

      J. Cell Science 119

      Pages: 2107-2118

    • Data Source
      KAKENHI-PROJECT-17014076
  • [Journal Article] aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.2004

    • Author(s)
      Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S.
    • Journal Title

      Curr Biology 14(16)

      Pages: 1425-1435

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12219215
  • [Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.2003

    • Author(s)
      Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, Y., Amano, Y., Ohno, S.
    • Journal Title

      J. Biol. Chem. 278(33)

      Pages: 31240-31250

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12219215
  • [Journal Article] The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression2003

    • Author(s)
      Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K-I., Ohno, S.
    • Journal Title

      Genes to Cells 8

      Pages: 311-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15209013
  • [Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.2003

    • Author(s)
      Mizuno K, Suzuki A, Hirose T, Kitamura K, Kutsuzawa K, Futaki M, Amano Y, Ohnos S
    • Journal Title

      J.Biol.Chem 278(33)

      Pages: 31240-31250

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15209013
  • [Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions.2003

    • Author(s)
      Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, Y., Futaki, M., Amano, Y., Ohno, S.
    • Journal Title

      J. Biol. Chem. 278(33)

      Pages: 31240-31250

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12219215
  • [Journal Article] Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions2003

    • Author(s)
      Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, K., Futaki, M., Amano, Y., Ohno, S.
    • Journal Title

      J. Biol. Chem. 278(33)

      Pages: 31240-31250

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15209013
  • [Journal Article] The second phase activation of protein kinase Cd at late G1 is required for DNA synthesis in serum-induced cell cycle progression.2003

    • Author(s)
      Kitamura K, Mizuno K, Etoh A, Akita Y, Miyamoto A, Nakayama K-I, Ohno S
    • Journal Title

      Genes to Cells 8

      Pages: 311-324

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15209013
  • [Journal Article] ASPP2 Regulates Epithelial Cell Polarity through the PAR Complex.

    • Author(s)
      Cong W, Hirose T, Harita Y, YamashitaA, Mizuno K, Hirano H, Ohno S.
    • Journal Title

      Current Biology (in press)

    • Data Source
      KAKENHI-PROJECT-17014076
  • 1.  OHNO Shigeo (10142027)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 13 results
  • 2.  HIRAI Shu-ichi (80228759)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  SUZUKI Atsushi (00264606)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 10 results
  • 4.  OSADA Shinichi (00244484)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  AKIMOTO Kazunori (70285104)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  HIROSE Tomonori (20381668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  秋田 朗子 (40124432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  杉山 由樹
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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