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SHIBAGAKI Yoshio  柴垣 芳夫

ORCIDConnect your ORCID iD *help
… Alternative Names

柴垣 芳夫  シバガキ ヨシオ

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Researcher Number 90235565
Other IDs
External Links
Affiliation (Current) 2025: 北里大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2015 – 2019: 北里大学, 薬学部, 講師
2013: 北里大学, 薬学部, 講師
2002 – 2004: 北里大学, 薬学部, 講師
1999 – 2000: 北里大学, 薬学部, 講師
1993: 北里大学, 薬学部・生理化学教室, 講師
Review Section/Research Field
Principal Investigator
Structural biochemistry / Virology / Functional biochemistry
Except Principal Investigator
Pediatrics / Living organism molecular science
Keywords
Principal Investigator
キャップ構造 / キャッピング酵素 / Transcription factor / in vitro transcription / Capping enzyme / in vitro転写反応 / 微生物ライブラリースクリーニング / Cap-snatching阻害活性 / 微生物代謝物スクリーニング / インフルエンザ転写反応 … More / リード化合物スクリーニング / 抗インフルエンザ薬 / キャップスナッチング / cap-snatching / antiinfluenza drug / cap structure / Protein phosphorylation / RNA polymerase II / C-terminal domain / 転写開始反応 / リン酸化CTD / S.cerevisiae / Cap structure / in vitro 転写反応 / 転写因子 / 出芽酵母 / 遺伝子発現 / 酵母 / 変異タンパク質 / 酵素活性中心 / 共有結合反応中間体 / mRNAキャッピング … More
Except Principal Investigator
プロテオミクス / 自己反応性抗原 / 先天性腎尿路異常(CAKUT) / 自己抗原 / 小児 / 膜性腎症 / 原因抗原 / 先天性腎尿路異常 / 小児膜性腎症 / p38 MAPキナーゼ / mTOR / ERK / リン酸化 / 二次元ゲル電気泳動 / キナーゼ Less
  • Research Projects

    (6 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (15 People)
  •  Clinicopathologic approach to pediatric membranous nephropathy associated with congenital anomaly of kidney and urinary tract and the antigenic target

    • Principal Investigator
      Kaneko Naoto
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Women's Medical University
  •  Anti-Inflienza drug screening targetted by cap-snatching mechanismPrincipal Investigator

    • Principal Investigator
      SHIBAGAKI Yoshio
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kitasato University
  •  A convenient proteomic system for kinase substrate identification

    • Principal Investigator
      HATTORI Seisuke
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      Kitasato University
  •  Involvement of mRNA capping enzyme in transcription initiationPrincipal Investigator

    • Principal Investigator
      SHIBAGAKI Yoshio
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Kitasato University
  •  Sructural and function analysis of yeast mRNA capping enzyme in transcription reaction.Principal Investigator

    • Principal Investigator
      SHIBAGAKI Yoshio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Kitasato University
  •  酵母mRNAキャッピング酵素の機能部位に関する研究Principal Investigator

    • Principal Investigator
      柴垣 芳夫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      Kitasato University

All 2017 2016 2015 2014 2013 2012 2011 2004 2003 2002 Other

All Journal Article Presentation

  • [Journal Article] Phosphoproteomic Analysis Identifies Signaling Pathways Regulated by Curcumin in Human Colon Cancer Cells2017

    • Author(s)
      TATSUHIRO SATO, YUTAKA HIGUCHI, YOSHIO SHIBAGAKI and SEISUKE HATTORI
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 9 Pages: 4789-4798

    • DOI

      10.21873/anticanres.11885

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08502
  • [Journal Article] Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation2017

    • Author(s)
      Kyoko Shirakabe, Takuya Omura, Yoshio Shibagaki, Emiko Mihara, Keiichi Homma, Yukinari Kato, Akihiko Yoshimura, Yoshinori Murakami, Junichi Takagi, Seisuke Hattori & Yoshihiro Ogawa
    • Journal Title

      Scientific reports

      Volume: 7 Issue: 1 Pages: 46174-46174

    • DOI

      10.1038/srep46174

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08502
  • [Journal Article] Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration2016

    • Author(s)
      Tatsuhiro Sato, Junko Ishii, Yuki Ota, Eri Sasaki, Yoshio Shibagaki, Seisuke Hattor
    • Journal Title

      Genes to Cells

      Volume: 未定 Issue: 6 Pages: 579-593

    • DOI

      10.1111/gtc.12366

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19015, KAKENHI-PROJECT-15K08502
  • [Journal Article] Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM102016

    • Author(s)
      Hazuki Yamada, Koji Tsutsumi, Yuki Nakazawa, Yoshio Shibagaki, Seisuke Hattori, Yasutaka Ohta
    • Journal Title

      PloS one

      Volume: 11 Issue: 1 Pages: e0146593-e0146593

    • DOI

      10.1371/journal.pone.0146593

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08502
  • [Journal Article] CCT2 https://www-kofu.jsps.go.jp/kofu1/images/bt_add_small.gifMutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability.2016

    • Author(s)
      Minegishi Y, Sheng X, Yoshitake K, Sergeev Y, Iejima D, Shibagaki Y, Monma N, Ikeo K, Furuno M, Zhuang W, Liu Y, Rong W, Hattori A, Iwata T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 33742-33742

    • DOI

      10.1038/srep33742

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293377, KAKENHI-PROJECT-15K08502
  • [Journal Article] Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.2015

    • Author(s)
      Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, Heard JJ, Tamanoi F, Hattori S.
    • Journal Title

      J Biol Chem.

      Volume: 290 Issue: 2 Pages: 1096-1105

    • DOI

      10.1074/jbc.m114.592402

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390259, KAKENHI-PROJECT-15K08502
  • [Journal Article] Identification of 4-Trimethylaminobutyraldehyde Dehydrogenase (TMABA-DH) as a Candidate Serum Autoantibody Target for Kawasaki Disease2015

    • Author(s)
      Atsuko Matsunaga, Yutaka Harita, Yoshio Shibagaki, Nobutaka Shimizu, Kazuhiko Shibuya, Hiroshi Ono, Hitoshi Kato, Takashi Sekine, Naoko Sakamoto, Takashi Igarashi, Seisuke Hattori
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0128189-e0128189

    • DOI

      10.1371/journal.pone.0128189

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08502, KAKENHI-PROJECT-26461621, KAKENHI-PROJECT-15H04880
  • [Journal Article] An efficient screening system for influenza virus cap-dependent endonuclease inhibitors2014

    • Author(s)
      Shibagaki Y, Ikuta N, Iguchi S, Takaki K, Watanabe S, Kaihotsu M, Masuda C, Maeyama K, Mizumoto K, Hattori S
    • Journal Title

      J Virol Methods

      Volume: S0166-0934(14) Pages: 48-2

    • DOI

      10.1016/j.jviromet.2014.02.005

    • Data Source
      KAKENHI-PROJECT-23510261
  • [Journal Article] proteomic approach for the elucidation of stimulus- and substrate-specificity of ectodomain shedding.2013

    • Author(s)
      Shirakabe K., Shibagaki Y., Yoshimura A., Koyasu S., Hattori S.
    • Journal Title

      J Proteomics

      Volume: 98 Pages: 233-243

    • DOI

      10.1016/j.jprot.2014.01.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22229004, KAKENHI-PROJECT-23510261, KAKENHI-PROJECT-24390259, KAKENHI-PUBLICLY-25113718, KAKENHI-PROJECT-25670235
  • [Journal Article] An adaptor protein complex of FRS2beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation2013

    • Author(s)
      後藤 典子
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 3 Pages: 345-352

    • DOI

      10.1111/cas.12086

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-23390087, KAKENHI-PROJECT-23510261, KAKENHI-PROJECT-23659192, KAKENHI-PROJECT-23659626, KAKENHI-PUBLICLY-24121705, KAKENHI-PROJECT-24700968, KAKENHI-PROJECT-25460357
  • [Journal Article] Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis2011

    • Author(s)
      Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S
    • Journal Title

      Mol Biol Cell

      Volume: 22 Issue: 11 Pages: 1824-1835

    • DOI

      10.1091/mbc.e10-12-0929

    • Data Source
      KAKENHI-PROJECT-23510261
  • [Journal Article] Functional interaction of mRNA capping enzyme with RNA polymerase II2004

    • Author(s)
      Wada, K., Shibagaki, Y., Hisatake, K., Fukuda, A., Mizumoto, K.
    • Journal Title

      Seikagaku 76

      Pages: 855-855

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] 転写初期反応におけるmRNAキャッピング酵素の役割2003

    • Author(s)
      柴垣芳夫
    • Journal Title

      生化学

      Pages: 939-939

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] 転写初期反応におけるRNA polymerase IIによるmRNAキャッピング化酵素の役割2003

    • Author(s)
      柴垣芳夫
    • Journal Title

      国際シンポジウムRNAフロンティア

      Pages: 175-175

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] The role of mRNA capping enzyme in pol II transcription initiation2003

    • Author(s)
      Shibagaki, Y., Nojima, T., Matsui, H., Hisatake, K., Fukuda, A., Mizumoto, K.
    • Journal Title

      The New Frontier of RNA Science RNA 2003 Kyoto Abstract

      Pages: 175-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] The role of mRNA capping enzyme in pol II transcription initiation2003

    • Author(s)
      Shibagaki, Y., Nojima, T., Hisatake, K., Fukuda, A., Mizumoto, K.
    • Journal Title

      Seikagaku 75

      Pages: 939-939

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] Involvement of mRNA capping enzyme in pol II initiation complex2002

    • Author(s)
      Shibagaki, Y., Hisatake, K., Fukuda, A., Fukamachi, N., Tsukamoto, T., Mizumoto, K.
    • Journal Title

      Seikagaku 74

      Pages: 1001-1001

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] RNA polymerase II転写複合体へのキャッピング酵素の組み込み2002

    • Author(s)
      柴垣芳夫
    • Journal Title

      生化学

      Pages: 1001-1001

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14580630
  • [Journal Article] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLC γ 1 following T-cell stimulation

    • Author(s)
      Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J
    • Journal Title

      Eur J Immunol

      Volume: in press

    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] Cap-snatching をターゲットとした抗インフルエンザ薬スクリーニング2016

    • Author(s)
      柴垣芳夫
    • Organizer
      第39日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K08502
  • [Presentation] Cap-snatching 反応をターゲットとした抗インフルエンザ薬スクリーニング2015

    • Author(s)
      柴垣芳夫1)、浅野 恵美子1)、兒玉 朋子1)、野村 大成1)、内田 龍児2)、供田 洋2)、服部 成介
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市中央区)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K08502
  • [Presentation] プロテオミクス解析によるシェディングの刺激・基質特異性の解明2013

    • Author(s)
      白壁恭子,柴垣芳夫,吉村昭彦,小安重夫,服部成介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Year and Date
      2013-12-03
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] mTOR Complex 2 Phosphorylates Filamin A to Regulate Cell Migration2013

    • Author(s)
      Tatsuhiro Sato, Yoshio Shibagaki, Seisuke Hattori
    • Organizer
      HUPO 12th annual world congress
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-09-17
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] mTORC2はfilamin Aを介して接着斑形成と細胞運動を制御する2013

    • Author(s)
      佐藤龍洋,石井淳子,太田悠貴,佐々木恵理,柴垣芳夫,服部成介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Year and Date
      2013-12-05
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] mTORC2は Filamin Aを介して細胞運動を制御する2012

    • Author(s)
      佐藤龍洋 ,柴垣芳夫 ,服部成介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡マリンメッセ、福岡
    • Year and Date
      2012-12-12
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] ERKは adducinをリン酸化し、 F-actinとの結合を調節する2012

    • Author(s)
      飯田直幸 ,吉本真吾 ,根岸豊 ,吉村憲彦 ,柴垣芳夫 ,服部成介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡マリンメッセ、福岡
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] 低分子量G蛋白質Rhebによるヌクレオチド生合成への関与2012

    • Author(s)
      赤須仁美 ,佐藤龍洋 ,柴垣芳夫 ,服部成介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡マリンメッセ、福岡
    • Year and Date
      2012-12-12
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] 低分子量Gタンパク質Rhebの新規シグナル伝達の解析2011

    • Author(s)
      赤須仁美、佐藤龍洋、柴垣芳夫、服部成介
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] RacGAP因子FilGAPはAfadinと結合し、腎糸球体上皮細胞におけるアクチン細胞骨格形成を制御する

    • Author(s)
      椎野 達大, 斉藤 康二, 望月 優加, 栗原 秀剛2, 張田 豊, 柴垣 芳夫, 服部 成介, 太田 安隆
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] mTOR complex 2 phosphorylates Filamin A to regulate cell migration.

    • Author(s)
      Sato T, Shibagaki Y, Hattori S
    • Organizer
      HUPO 12th annual world congress
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] FilGAPとAGAP1の相互作用によるRac1シグナルとArf1シグナルのクロストーク

    • Author(s)
      中村 遥, 柴垣 芳夫, 服部 成介, 太田 安隆
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] mTORC2はFilamin Aを介して細胞運動を制御する

    • Author(s)
      佐藤 龍洋, 柴垣 芳夫, 服部 成介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] プロテオミクス解析によるシェディングの刺激・基質特異性の解明

    • Author(s)
      白壁 恭子,柴垣 芳夫,吉村 昭彦,小安 重夫,服部 成介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] 低分子量G蛋白質Rhebによるヌクレオチド生合成への関与

    • Author(s)
      赤須 仁美, 佐藤 龍洋, 柴垣 芳夫, 服部 成介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] ERKはadducinをリン酸化し、F-actinとの結合を調節する

    • Author(s)
      飯田 直幸, 吉本 真吾, 根岸 豊, 吉村 憲彦, 柴垣 芳夫, 服部 成介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23510261
  • [Presentation] mTORC2 はfilamin A を介して接着斑形成と細胞運動を制御する

    • Author(s)
      佐藤 龍洋,石井 淳子,太田 悠貴,佐々木 恵理,柴垣 芳夫,服部 成介
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23510261
  • 1.  MIZUMOTO Kiyohisa (80092344)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  HATTORI Seisuke (50143508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 19 results
  • 3.  SATO Tatsuhiro (70547893)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 4.  IIDA Naoyuki (10376618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  HISATAKE Koji (70271236)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 6.  Kaneko Naoto (90791955)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  張田 豊 (10451866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  服部 元史 (50192274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  神田 祥一郎 (60632651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  五島 直樹 (70215482)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  三浦 健一郎 (70408483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  秋岡 祐子 (90212422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  小安 重夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  後藤 典子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  岩田 岳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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