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Yamaguchi Noriko  山口 典子

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… Alternative Names

YAMAGUCHI Noriko  山口 典子

山口 典子  ヤマグチ ノリコ

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Researcher Number 90251553
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2015: 秋田大学, 大学院医学系研究科, 准教授
2012 – 2015: 秋田大学, 医学(系)研究科(研究院), 准教授
2007: 秋田大学, 医学部, 准教授
2006: 秋田大学, 医学部, 助教授
2000 – 2005: 東京医科歯科大学, 難治疾患研究所, 助手
1995: 東京医科歯科大学, 難治疾患研究所, 助手
Review Section/Research Field
Principal Investigator
General surgery / Biological Sciences / General surgery / Integrated Nutrition Science
Except Principal Investigator
Biomedical engineering/Biological material science / Digestive surgery / Integrated Nutrition Science / Pediatric surgery / Digestive surgery / Cell biology
Keywords
Principal Investigator
コラーゲン / がん / エンドスタチン / 血管新生 / Cancer / Endostatin / 腫瘍 / Collagen / Angiogenesis / ガン … More / Rheumatoid arthritis / Angi ogenesis / 関節リウマチ / Tumor / NASH / 肝線維化 / 細胞外マトリックス / ビタミンE / ビタミンE / トコール / 肝線維症 / アノイキス誘導 / MMP / アノイキス / 肝臓星細胞 / 肝硬変 … More
Except Principal Investigator
in vitro translation / endostatin / scid-hu mouse / ヤツメウナギ / コラーゲン / Gelatin allergy / Endostatin / Drug delivery / Homotrimer-gel / α1 chain / Collagen / ゼラチンアレルギー / エンドスタチン / ドラッグデリバリー / ホモトリマーゲル / α1鎖 / Liver metastasis model of human colorectal cancer / common-γ double knockout mouse / RAG2 / human endostatin / hu mice / scid / ヒト大腸癌転移モデル / RAG2ダブルノックアウトマウス / γ鎖 / タンパク質 / 酵素 / 小腸 / 肝臓 / 星細胞 / ビタミンA / TUNEL法 / 微細形態 / レチノイド / 細胞外マトリックス / 肝臓星細胞 / 胆汁 / 胆道閉鎖症 / 癌特異抗原 / ゼノ移植 / 免疫不全マウス / 免疫療法 / 線維芽細胞 / ゲル培養 / 空間情報 / 三次元情報 / 転写制御 Less
  • Research Projects

    (12 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (18 People)
  •  Modulation of enzymatic activities of vitamin A-metabolizing enzymes by cellular retinol-binding proteins

    • Principal Investigator
      Mezaki Yoshihiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrated Nutrition Science
    • Research Institution
      Jikei University School of Medicine
      Akita University
  •  Elucidation of the mechanism of anoikis induction by vitamin E-analogous compound and application to the pharmacotherapy for hepatic cirrhosis.Principal Investigator

    • Principal Investigator
      Yamaguchi Noriko
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrated Nutrition Science
    • Research Institution
      Akita University
  •  胆道閉鎖症治療への応用を目指した胆汁成分の新しい処理機構の解明

    • Principal Investigator
      SENOO Haruki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatric surgery
    • Research Institution
      Akita University
  •  Analysis of the mechanisms of action of angiogenesis inhibitor, endostatin and its dynamic localization in tumor blood vessels.Principal Investigator

    • Principal Investigator
      YAMAGUCHI Noriko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  γ鎖/RAG2ダブルノックアウトマウスを用いた新しい癌特異的免疫反応評価法の確立

    • Principal Investigator
      岡部 聰
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  Preparation of homotrimer-gels composed of type I collagen α1 chain for novel biomaterials as drug-delivery.

    • Principal Investigator
      HORI Hisae
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of the mechanisms of expression and function of endostatin, a novel anti-cancer medicine derived from basement membrane collagen.Principal Investigator

    • Principal Investigator
      YAMAGUCHI Noriko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  基底膜コラーゲンの分解とがん浸潤、転移抑制作用の発現Principal Investigator

    • Principal Investigator
      山口 典子
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  血管基底膜構築コラーゲンのがん浸潤、転移制御作用Principal Investigator

    • Principal Investigator
      山口 典子
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Mechanism of tumor growth suppression, tumor regression and induction of dormancy by endostatin, new antiangiogenic inhibitor.Principal Investigator

    • Principal Investigator
      YAMAGUCHI Noriko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Tokyo Medicai and Dental University
  •  Establishment of an appropriate metastasis model and a novel treatment for advanced human colorectal cancer using RAG2/common-γ double knockout mice

    • Principal Investigator
      NAKAMURA Masataka, 岡部 聡
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  細胞による三次元(空間)情報の認識機構の研究-コラーゲン遺伝子の三次元情報認識配列の解析

    • Principal Investigator
      畑 隆一郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Medical and Dental University

All 2015 2014 2013 2012 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] The role of retinoic acid receptors in activated hepatic stellate cells2013

    • Author(s)
      Mezaki Y., Morii M., Hebiguchi T., Yoshikawa K., Yamaguchi N, Yoshino H., Senoo H
    • Journal Title

      Med. Hypotheses

      Volume: 81(2) Issue: 2 Pages: 222-224

    • DOI

      10.1016/j.mehy.2013.04.045

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592623, KAKENHI-PROJECT-24614003, KAKENHI-PROJECT-25504001
  • [Journal Article] Differential Increases in the Expression of Intermediate Filament Proteins and Concomitant Morphological Changes of Transdifferentiating Rat Hepatic Stellate Cells Observed <i>In Vitro</i>2013

    • Author(s)
      Mezaki Y., Morii M., Hebiguchi T., Yoshikawa K., Yamaguchi N, Miura M., Imai K., Yoshino H., Senoo H
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 46 Issue: 5 Pages: 137-143

    • DOI

      10.1267/ahc.13007

    • NAID

      130003381866

    • ISSN
      0044-5991, 1347-5800
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592623, KAKENHI-PROJECT-24614003, KAKENHI-PROJECT-25504001
  • [Journal Article] An analysis of the functional mechanisms of endostatin. -The anti-angiogenic activity of endostatin is mediated by its multiple binding ability.2004

    • Author(s)
      Yamaguchi, N.
    • Journal Title

      Connective Tissue 36

      Pages: 171-178

    • NAID

      110004014521

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15500314
  • [Journal Article] Ananalysis of the functional mechanisms of endostatin. -The anti-angiogenic activity of endostatin is mediated by its multiple binding Ability.2004

    • Author(s)
      Yamaguchi, N.
    • Journal Title

      Connective Tissue 36

      Pages: 171-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15500314
  • [Journal Article] An analysis of the functional mechanisms of endostatin. -The anti-angiogenic activity of endostatin is mediated by its multiple binding ability-2004

    • Author(s)
      Yamaguchi, N.
    • Journal Title

      Connective Tissue 36

      Pages: 171-178

    • NAID

      110004014521

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591250
  • [Journal Article] An analysis of the functional mechanisms of endostalin. -the anti-angiogenic activity of endostatin is mediated by its multiple binding ability-2004

    • Author(s)
      Yamaguchi, N.
    • Journal Title

      Connective Tissue 36

      Pages: 171-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591250
  • [Journal Article] The function and the genetic disorder of type, XVIII collagen2003

    • Author(s)
      Yamaguchi, N
    • Journal Title

      The Cell 35

      Pages: 136-139

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15500314
  • [Journal Article] Arthritis-inhibiting effect of systemic administration of endostatin in passive marine collagen-induced arthritis.2003

    • Author(s)
      Kurosaka, D.Yoshida K, Yasuda J, Yokoyama T, Kingetsu I, Yamaguchi N, Joh K, Matsushima M, Saito S, Yamada A.
    • Journal Title

      Ann.Rheum.Dis 62

      Pages: 677-679

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15500314
  • [Journal Article] XVIII型コラーゲンの機能と遺伝子異常症2003

    • Author(s)
      山口典子
    • Journal Title

      細胞 35

      Pages: 136-139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15500314
  • [Presentation] ビタミンE類縁化合物、トコールは肝臓星細胞に対して線維形成コラーゲン合成を低下させ、アノイキスを誘導する2015

    • Author(s)
      山口典子、目崎喜弘,三浦光隆,稲垣豊,吉川究
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 肝臓星細胞のビタミンA脂質滴形成におけるPerilipin 2/ADRP、Perilipin 3/TIP47の関与2015

    • Author(s)
      吉川究、目崎喜弘、森居真也子、三浦光隆、今井克幸、山口典子
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 活性化肝臓星細胞における中間径フィラメントの役割2014

    • Author(s)
      目崎喜弘,森井真也子,蛇口琢,吉川 究,山口典子,三浦光隆,今井克幸,吉野裕顕,妹尾春樹
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Data Source
      KAKENHI-PROJECT-25504001
  • [Presentation] コラーゲン分解物の生理活性2014

    • Author(s)
      山口典子
    • Organizer
      第23回アジア栄養科学ワークショップ
    • Place of Presentation
      中村学園大学
    • Year and Date
      2014-11-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 肝臓星細胞(ビタミンA貯蔵細胞)の活性化における中間径フィラメントの発現量と局在の変化2013

    • Author(s)
      目崎喜弘、森井真也子、蛇口琢、吉川究、山口典子、三浦光隆、今井克幸、吉野裕顕、妹尾春樹
    • Organizer
      日本ビタミン学会第65回大会
    • Place of Presentation
      一橋大学
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] Differential increases in the expression of intermediate filament proteins in transdifferentiating rat hepatic stellate cells.2013

    • Author(s)
      Y Mezaki, M Morii, T Hebiguchi, K Yoshikawa, N Yamaguchi, M Miura, K Imai, H Yoshino, H Senoo
    • Organizer
      17th International Symposium on Cells of the Hepatic Sinusoid
    • Place of Presentation
      Osaka International Convention Center
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 肝臓星細胞(ビタミンA貯蔵細胞)の活性化における中間径フィラメントの発現量と局在の変化2013

    • Author(s)
      目崎喜弘,森井真也子,蛇口 琢,吉川 究,山口典子,三浦光隆,今井克幸,吉野裕顕,妹尾春樹
    • Organizer
      日本ビタミン学会第65回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25504001
  • [Presentation] Involvement of perilipin2/ADRP and perilipin3/TIP47 in the formation of vitamin A-storing lipid droplets in hepatic stellate cells.2013

    • Author(s)
      K Yoshikawa, Y Mezaki, T Hebiguchi, M Miura, K Imai, N Yamaguchi
    • Organizer
      17th International Symposium on Cells of the Hepatic Sinusoid
    • Place of Presentation
      Osaka International Convention Center
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] Differential increases in the expression of intermediate filament proteins in transdifferentiating rat hepatic stellate cells2013

    • Author(s)
      Mezaki Y., Morii M., Hebiguchi T., Yoshikawa K., Yamaguchi N., Miura M., Imai K., Yoshino H. Senoo H.
    • Organizer
      17th International Symposium on Cells of Hepatic Sinusoid
    • Place of Presentation
      Osaka
    • Data Source
      KAKENHI-PROJECT-25504001
  • [Presentation] ビタミンE類縁化合物、トコールの肝臓星細胞に対するアノイキス誘導2013

    • Author(s)
      山口典子、目崎喜弘、三浦光隆、稲垣豊、吉川究
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 肝臓星細胞のビタミンA脂質滴形成におけるPerilipin 3/TIP47の関与2013

    • Author(s)
      吉川究、目崎喜弘、森井真也子、蛇口琢、三浦光隆、今井克幸、山口典子
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      ウインクあいち
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] Induction of Anoikis by Tocol in Rat Hepatic Stellate cells2012

    • Author(s)
      Noriko Yamaguchi, Yoshihiro Mezaki, Mitsutaka Miura, Mayako Morii, Katsuyuki Imai, Yutaka Inagaki, Kiwamu Yoshikawa
    • Organizer
      The 35th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 肝臓星細胞のビタミンA脂質滴

    • Author(s)
      吉川究、目崎喜弘、蛇口琢、三浦光隆、今井克幸、山口典子
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] 肝臓星細胞のビタミンA脂質滴形成におけるADRP、TIP47の関与

    • Author(s)
      吉川究、目崎喜弘、蛇口琢、三浦光隆、今井克幸、山口典子
    • Organizer
      第120回日本解剖学会総会・全国学術集会(第92回日本生理学会大会との合同大会)
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-24614003
  • [Presentation] ビタミンE類縁化合物、トコールの肝臓星細胞に対するアノイキス誘導はMMP合成の促進を伴う

    • Author(s)
      山口典子、目崎喜弘、三浦光隆、稲垣豊、吉川究
    • Organizer
      第8回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-24614003
  • 1.  OKABE Satoshi (60242187)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  HORI Hisae (80014190)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  AOYAGI Masaru (40134704)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  NAKAMURA Masataka (30180392)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIKAWA Kiwamu (90400481)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  MEZAKI Yoshihiro (40431621)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 14 results
  • 7.  SENOO Haruki (90171355)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 8.  KUBOTA Shunichirou (00260480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  畑 隆一郎 (10014276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  杉原 健一 (10171167)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  河上 裕 (50161287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  萱場 広之 (70224706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  吉野 裕顕 (90182807)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  加藤 哲夫 (20004963)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  服部 俊治
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MAYAKO Morii
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  芳川 究
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 14 results
  • 18.  蛇口 琢
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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