Yamaguchi Noriko 山口典子

… Alternative Names

YAMAGUCHI Noriko 山口典子

山口典子ヤマグチノリコ

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Researcher Number	90251553
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015: 秋田大学, 大学院医学系研究科, 准教授 2012 – 2015: 秋田大学, 医学(系)研究科(研究院), 准教授 2007: 秋田大学, 医学部, 准教授 2006: 秋田大学, 医学部, 助教授 2000 – 2005: 東京医科歯科大学, 難治疾患研究所, 助手 1995: 東京医科歯科大学, 難治疾患研究所, 助手
Review Section/Research Field	Principal Investigator General surgery / Biological Sciences / General surgery / Integrated Nutrition Science Except Principal Investigator Biomedical engineering/Biological material science / Digestive surgery / Integrated Nutrition Science / Pediatric surgery / Digestive surgery / Cell biology
Keywords	Principal Investigator コラーゲン / がん / エンドスタチン / 血管新生 / Cancer / Endostatin / 腫瘍 / Collagen / Angiogenesis / ガン … More / Rheumatoid arthritis / Angi ogenesis / 関節リウマチ / Tumor / NASH / 肝線維化 / 細胞外マトリックス / ビタミンE / ビタミンＥ / トコール / 肝線維症 / アノイキス誘導 / MMP / アノイキス / 肝臓星細胞 / 肝硬変 … More Except Principal Investigator in vitro translation / endostatin / scid-hu mouse / ヤツメウナギ / コラーゲン / Gelatin allergy / Endostatin / Drug delivery / Homotrimer-gel / α1 chain / Collagen / ゼラチンアレルギー / エンドスタチン / ドラッグデリバリー / ホモトリマーゲル / α1鎖 / Liver metastasis model of human colorectal cancer / common-γ double knockout mouse / RAG2 / human endostatin / hu mice / scid / ヒト大腸癌転移モデル / RAG2ダブルノックアウトマウス / γ鎖 / タンパク質 / 酵素 / 小腸 / 肝臓 / 星細胞 / ビタミンA / TUNEL法 / 微細形態 / レチノイド / 細胞外マトリックス / 肝臓星細胞 / 胆汁 / 胆道閉鎖症 / 癌特異抗原 / ゼノ移植 / 免疫不全マウス / 免疫療法 / 線維芽細胞 / ゲル培養 / 空間情報 / 三次元情報 / 転写制御 Less

Modulation of enzymatic activities of vitamin A-metabolizing enzymes by cellular retinol-binding proteins
- Principal Investigator
  
  Mezaki Yoshihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Jikei University School of Medicine
  Akita University
Elucidation of the mechanism of anoikis induction by vitamin E-analogous compound and application to the pharmacotherapy for hepatic cirrhosis.Principal Investigator
- Principal Investigator
  
  Yamaguchi Noriko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Akita University
胆道閉鎖症治療への応用を目指した胆汁成分の新しい処理機構の解明
- Principal Investigator
  
  SENOO Haruki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatric surgery
- Research Institution
  Akita University
Analysis of the mechanisms of action of angiogenesis inhibitor, endostatin and its dynamic localization in tumor blood vessels.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Noriko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Medical and Dental University
γ鎖/RAG2ダブルノックアウトマウスを用いた新しい癌特異的免疫反応評価法の確立
- Principal Investigator
  
  岡部聰
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo Medical and Dental University
Preparation of homotrimer-gels composed of type I collagen α1 chain for novel biomaterials as drug-delivery.
- Principal Investigator
  
  HORI Hisae
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Medical and Dental University
Analysis of the mechanisms of expression and function of endostatin, a novel anti-cancer medicine derived from basement membrane collagen.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Noriko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Medical and Dental University
基底膜コラーゲンの分解とがん浸潤、転移抑制作用の発現Principal Investigator
- Principal Investigator
  
  山口典子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
血管基底膜構築コラーゲンのがん浸潤、転移制御作用Principal Investigator
- Principal Investigator
  
  山口典子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Mechanism of tumor growth suppression, tumor regression and induction of dormancy by endostatin, new antiangiogenic inhibitor.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Noriko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Medicai and Dental University
Establishment of an appropriate metastasis model and a novel treatment for advanced human colorectal cancer using RAG2/common-γ double knockout mice
- Principal Investigator
  
  NAKAMURA Masataka, 岡部聡
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo Medical and Dental University
細胞による三次元(空間)情報の認識機構の研究-コラーゲン遺伝子の三次元情報認識配列の解析
- Principal Investigator
  
  畑隆一郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University

All 2015 2014 2013 2012 2004 2003 Other

All Journal Article Presentation

[Journal Article] The role of retinoic acid receptors in activated hepatic stellate cells2013
- Author(s)
  Mezaki Y., Morii M., Hebiguchi T., Yoshikawa K., Yamaguchi N, Yoshino H., Senoo H
- Journal Title
  
  Med. Hypotheses
  
  Volume: 81(2) Issue: 2 Pages: 222-224
- DOI
  10.1016/j.mehy.2013.04.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592623, KAKENHI-PROJECT-24614003, KAKENHI-PROJECT-25504001
[Journal Article] Differential Increases in the Expression of Intermediate Filament Proteins and Concomitant Morphological Changes of Transdifferentiating Rat Hepatic Stellate Cells Observed <i>In Vitro</i>2013
- Author(s)
  Mezaki Y., Morii M., Hebiguchi T., Yoshikawa K., Yamaguchi N, Miura M., Imai K., Yoshino H., Senoo H
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 46 Issue: 5 Pages: 137-143
- DOI
  10.1267/ahc.13007
- NAID
  130003381866
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592623, KAKENHI-PROJECT-24614003, KAKENHI-PROJECT-25504001
[Journal Article] An analysis of the functional mechanisms of endostatin. -The anti-angiogenic activity of endostatin is mediated by its multiple binding ability.2004
- Author(s)
  Yamaguchi, N.
- Journal Title
  
  Connective Tissue 36
  
  Pages: 171-178
- NAID
  110004014521
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500314
[Journal Article] Ananalysis of the functional mechanisms of endostatin. -The anti-angiogenic activity of endostatin is mediated by its multiple binding Ability.2004
- Author(s)
  Yamaguchi, N.
- Journal Title
  
  Connective Tissue 36
  
  Pages: 171-178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500314
[Journal Article] An analysis of the functional mechanisms of endostatin. -The anti-angiogenic activity of endostatin is mediated by its multiple binding ability-2004
- Author(s)
  Yamaguchi, N.
- Journal Title
  
  Connective Tissue 36
  
  Pages: 171-178
- NAID
  110004014521
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591250
[Journal Article] An analysis of the functional mechanisms of endostalin. -the anti-angiogenic activity of endostatin is mediated by its multiple binding ability-2004
- Author(s)
  Yamaguchi, N.
- Journal Title
  
  Connective Tissue 36
  
  Pages: 171-178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591250
[Journal Article] The function and the genetic disorder of type, XVIII collagen2003
- Author(s)
  Yamaguchi, N
- Journal Title
  
  The Cell 35
  
  Pages: 136-139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500314
[Journal Article] Arthritis-inhibiting effect of systemic administration of endostatin in passive marine collagen-induced arthritis.2003
- Author(s)
  Kurosaka, D.Yoshida K, Yasuda J, Yokoyama T, Kingetsu I, Yamaguchi N, Joh K, Matsushima M, Saito S, Yamada A.
- Journal Title
  
  Ann.Rheum.Dis 62
  
  Pages: 677-679
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500314
[Journal Article] XVIII型コラーゲンの機能と遺伝子異常症2003
- Author(s)
  山口典子
- Journal Title
  
  細胞 35
  
  Pages: 136-139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500314
[Presentation] ビタミンＥ類縁化合物、トコールは肝臓星細胞に対して線維形成コラーゲン合成を低下させ、アノイキスを誘導する2015
- Author(s)
  山口典子、目崎喜弘，三浦光隆，稲垣豊，吉川究
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 肝臓星細胞のビタミンＡ脂質滴形成におけるPerilipin 2/ADRP、Perilipin 3/TIP47の関与2015
- Author(s)
  吉川究、目崎喜弘、森居真也子、三浦光隆、今井克幸、山口典子
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 活性化肝臓星細胞における中間径フィラメントの役割2014
- Author(s)
  目崎喜弘，森井真也子，蛇口琢，吉川　究，山口典子，三浦光隆，今井克幸，吉野裕顕，妹尾春樹
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-25504001
[Presentation] コラーゲン分解物の生理活性2014
- Author(s)
  山口典子
- Organizer
  第23回アジア栄養科学ワークショップ
- Place of Presentation
  中村学園大学
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 肝臓星細胞（ビタミンA貯蔵細胞）の活性化における中間径フィラメントの発現量と局在の変化2013
- Author(s)
  目崎喜弘、森井真也子、蛇口琢、吉川究、山口典子、三浦光隆、今井克幸、吉野裕顕、妹尾春樹
- Organizer
  日本ビタミン学会第65回大会
- Place of Presentation
  一橋大学
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] Differential increases in the expression of intermediate filament proteins in transdifferentiating rat hepatic stellate cells.2013
- Author(s)
  Y Mezaki, M Morii, T Hebiguchi, K Yoshikawa, N Yamaguchi, M Miura, K Imai, H Yoshino, H Senoo
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka International Convention Center
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 肝臓星細胞（ビタミンA貯蔵細胞）の活性化における中間径フィラメントの発現量と局在の変化2013
- Author(s)
  目崎喜弘，森井真也子，蛇口　琢，吉川　究，山口典子，三浦光隆，今井克幸，吉野裕顕，妹尾春樹
- Organizer
  日本ビタミン学会第65回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25504001
[Presentation] Involvement of perilipin2/ADRP and perilipin3/TIP47 in the formation of vitamin A-storing lipid droplets in hepatic stellate cells.2013
- Author(s)
  K Yoshikawa, Y Mezaki, T Hebiguchi, M Miura, K Imai, N Yamaguchi
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka International Convention Center
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] Differential increases in the expression of intermediate filament proteins in transdifferentiating rat hepatic stellate cells2013
- Author(s)
  Mezaki Y., Morii M., Hebiguchi T., Yoshikawa K., Yamaguchi N., Miura M., Imai K., Yoshino H. Senoo H.
- Organizer
  17th International Symposium on Cells of Hepatic Sinusoid
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-25504001
[Presentation] ビタミンE類縁化合物、トコールの肝臓星細胞に対するアノイキス誘導2013
- Author(s)
  山口典子、目崎喜弘、三浦光隆、稲垣豊、吉川究
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 肝臓星細胞のビタミンA脂質滴形成におけるPerilipin 3/TIP47の関与2013
- Author(s)
  吉川究、目崎喜弘、森井真也子、蛇口琢、三浦光隆、今井克幸、山口典子
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] Induction of Anoikis by Tocol in Rat Hepatic Stellate cells2012
- Author(s)
  Noriko Yamaguchi, Yoshihiro Mezaki, Mitsutaka Miura, Mayako Morii, Katsuyuki Imai, Yutaka Inagaki, Kiwamu Yoshikawa
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 肝臓星細胞のビタミンＡ脂質滴
- Author(s)
  吉川究、目崎喜弘、蛇口琢、三浦光隆、今井克幸、山口典子
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] 肝臓星細胞のビタミンＡ脂質滴形成におけるADRP、TIP47の関与
- Author(s)
  吉川究、目崎喜弘、蛇口琢、三浦光隆、今井克幸、山口典子
- Organizer
  第120回日本解剖学会総会・全国学術集会（第92回日本生理学会大会との合同大会）
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Invited
- Data Source
  KAKENHI-PROJECT-24614003
[Presentation] ビタミンE類縁化合物、トコールの肝臓星細胞に対するアノイキス誘導はMMP合成の促進を伴う
- Author(s)
  山口典子、目崎喜弘、三浦光隆、稲垣豊、吉川究
- Organizer
  第8回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24614003

1. OKABE Satoshi (60242187)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. HORI Hisae (80014190)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. AOYAGI Masaru (40134704)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. NAKAMURA Masataka (30180392)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YOSHIKAWA Kiwamu (90400481)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. MEZAKI Yoshihiro (40431621)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
7. SENOO Haruki (90171355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. KUBOTA Shunichirou (00260480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 畑隆一郎 (10014276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 杉原健一 (10171167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 河上裕 (50161287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 萱場広之 (70224706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 吉野裕顕 (90182807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 加藤哲夫 (20004963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 服部俊治

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MAYAKO Morii

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 芳川究

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results
18. 蛇口琢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Noriko 山口 典子

YAMAGUCHI Noriko 山口 典子

山口 典子 ヤマグチ ノリコ

Research Projects

Research Products

Co-Researchers

Modulation of enzymatic activities of vitamin A-metabolizing enzymes by cellular retinol-binding proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of anoikis induction by vitamin E-analogous compound and application to the pharmacotherapy for hepatic cirrhosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胆道閉鎖症治療への応用を目指した胆汁成分の新しい処理機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanisms of action of angiogenesis inhibitor, endostatin and its dynamic localization in tumor blood vessels.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

γ鎖/RAG2ダブルノックアウトマウスを用いた新しい癌特異的免疫反応評価法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preparation of homotrimer-gels composed of type I collagen α1 chain for novel biomaterials as drug-delivery.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanisms of expression and function of endostatin, a novel anti-cancer medicine derived from basement membrane collagen.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

基底膜コラーゲンの分解とがん浸潤、転移抑制作用の発現Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血管基底膜構築コラーゲンのがん浸潤、転移制御作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of tumor growth suppression, tumor regression and induction of dormancy by endostatin, new antiangiogenic inhibitor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of an appropriate metastasis model and a novel treatment for advanced human colorectal cancer using RAG2/common-γ double knockout mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞による三次元(空間)情報の認識機構の研究-コラーゲン遺伝子の三次元情報認識配列の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The role of retinoic acid receptors in activated hepatic stellate cells2013

Author(s)

Yamaguchi Noriko 山口典子

YAMAGUCHI Noriko 山口典子

山口典子ヤマグチノリコ