TOKUTOMI YOSHIKO 徳冨芳子

… Alternative Names

徳冨芳子トクトミヨシコ

TOKUTOMI Yoshiko 徳冨芳子

徳富芳子トクトミヨシコ

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Researcher Number	90253723
Other IDs
External Links
Affiliation (Current)	2025: 九州看護福祉大学, 看護福祉学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 九州看護福祉大学, 看護福祉学部, 教授 2012 – 2017: 尚絅大学, 生活科学部, 教授 2010: 尚絅大学, 生活科学部, 教授 2010: Kumamoto University, 生活科学部, 教授 2009: Kumamoto University, 大学院・生命科学研究部, 助教 … More 2008: Kumamoto University, 大学院・医学薬学研究部, 助教 2003 – 2005: KUMAMOTO University, Grad.Sch.Med.Sci., Instructor, 大学院・医学薬学研究部, 助手 2002: 熊本大学, 医学部, 講師 1994 – 2002: 熊本大学, 医学部, 助手 1998: 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 08030:Family and consumer sciences, and culture and living-related / Eating habits / Eating habits, studies on eating habits / General pharmacology Except Principal Investigator General pharmacology / General pharmacology / General physiology
Keywords	Principal Investigator c-kit / caffeine / ryanodine / ポリフェノール / 機能性食品成分 / パッチクランプ法 / mouse / smooth muscle / fura-2 / マウス … More / 細胞内Ca^<2+>貯蔵部位 / フラボノイド / メタボリック症候群 / ryanodine感受性Ca^<2+>放出 / Ca^<2+>貯蔵部位 / 細胞内Ca^<2+>動態 / 平滑筋細胞 / 内臓脂肪 / 食品機能性成分 / カロテノイド / 脂肪細胞 / 肥満 / 代謝異常症 / α_1-acid glycoprotein / pacemaker / intracellular Ca^<2+> / contraction / 等尺性張力 / α_1酸性糖蛋白質 / ペースメーカー / 細胞内Ca^<2+> / 収縮 / 平滑筋 / Patch-clamp technique / Ca^<2+> storage / ryanodine感受性Ca^<2+>ストア / 胃平滑筋 / db / 一酸化窒素 / NO / 心血管系 / eNOS / cGMP / ryanadine感受性Ca^<2+>放出 / C-kit … More Except Principal Investigator パッチクランプ法 / patch-clamp technique / AMPA / pacemaker / mouse / smooth muscle / 平滑筋 / マウス / c-kit / apoptosis / necrosis / electromagnetic stimulation / myelination / Schwann cell / neuron / アポトーシス / ネクローシス / 磁気刺激 / 再髄鞘化 / シュワン細胞 / ニューロン / Ca^<2+> / autonomic motility / Kit / caffeine / 細胞内Ca^<2+>貯蔵部位 / 細胞内カルシウム / ペースメーカー細胞 / 自動運動能 / c-Kit / kainate receptor-mediated excitatory postsynaptic currents / cortex / hippocampus / synaptic formation / neurite elongation / anti c-KIT monoclonal antibody (ACK2) / kainate型シナプス活動 / 抗 c-KIT モノクローナル抗体 / 脊髄後根神経節細胞 / kainate型シナプス / 大脳皮質ニューロン / 海馬ニューロン / シナプスの形成 / 神経突起の伸展 / 抗c-KITモノクローナル抗体 / intracellular Ca^<2+> / Ca^<2+> storage / development / TEA感受性Ca^<2+>活性化K^+電流 / カフェイン・カルバコール応答 / 細胞内Ca濃度 / マウス膀胱平滑筋 / Ca^<2+>放出機構 / イノシトール三燐酸受容体 / リアノジン受容体 / c-kit陽性細胞 / Ca^<2+>貯蔵部位 / 細胞内Ca^<2+> / 分化 / ペースメーカー / cultured c-kit (+) cell / GI motility ileum / antibody for kit-protein (ACK2) / c-kit tyrosinekinase / gastrointestinal tract / pacemaker activity / interstitial cell (IC) / ryanodine感受性Ca^<2+>貯蔵部位 / c-kit発現 / 自発性Ca^<2+>-activated K^+電流 / 膀胱平滑筋 / Ca^<2+>-activated K^+電流 / 細胞内Ca^<2+>濃度測定 / 胃平滑筋 / 抗c-kitモノクローナル抗体(ACK2) / c-kit発現細胞 / 自動運動のペースメーカー機構 / ACK2に対する蛍光抗体法 / アセチルコリン / ブラジキニン / 麻痺性イレウス / モノクローナル抗体(ACK2) / プロトオンコジーンc-kit / シナプス形成 / シナプス応答 / 中枢神経機能 / C-KITチロシンキナーゼレセプター Less

脂肪細胞機能制御因子を標的とした食品機能性成分によるメタボリック症候群予防の検討Principal Investigator
- Principal Investigator
  
  徳冨芳子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Kyushu University of Nursing and Social Welfare
Studies on the molecular mechanisms of effects of polyphenols on risk factors for glucose and lipid metabolic disorders aiming for the prevention of the metabolic syndromePrincipal Investigator
- Principal Investigator
  
  TOKUTOMI Yoshiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Shokei University
Studies on the active ingredients in functional foods for risk reduction of the metabolic syndromePrincipal Investigator
- Principal Investigator
  
  TOKUTOMI YOSHIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Shokei University
Studies on the roles for 8-nitroguanosine 3',5'-cyclic monophosphate in the cardiovascular system and the applications to drug discovery.Principal Investigator
- Principal Investigator
  
  TOKUTOMI Yoshiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
An experimental model for axonal regeneration in vitro and its application
- Principal Investigator
  
  TOKUTOMI Naofumi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sojo University
  Kumamoto University
Roles of Kit signalling in smooth muscle tissues
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Roles of c-kit in development and pathophysiology of smooth musclePrincipal Investigator
- Principal Investigator
  
  TOKUTOMI Yoshiko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
Roles of c-kit in functional development of Ca^<2+> release mechanism in smooth muscle cellsPrincipal Investigator
- Principal Investigator
  
  TOKUTOMI Yoshiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Molecular mechanism of development of mammalian smooth mscle
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Roles of c-KIT on the development in synaptic function and CaィイD12+ィエD1 signaling
- Principal Investigator
  
  TOKUTOMI Nofumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
平滑筋細胞の機能発達におけるC-kit陽性細胞の制御機構Principal Investigator
- Principal Investigator
  
  徳富芳子 (徳冨芳子)
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
中枢シナプス可塑性におけるc-kitチロシンキナーゼレセプターの役割
- Principal Investigator
  
  TOKUTOMI Naofumi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kumamoto University
A Role of c-kit tyrosinekinase of physiological development of the gastrointestinal pacemaker activity
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY

All 2017 2015 2013 2011 2010 2009 2006 2005 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] Roles of calcium-activated and voltage-dependent potassium channels in polyp henol-induced vasorelaxation of isolated mouse aortic rings2017
- Author(s)
  Eriko Motomura, Yoshiko Tokutomi, Naofumi Tokutomi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-15K00865
[Journal Article] Effects of polyphenols on vascular response in mice fed on a high fat diet.2015
- Author(s)
  Toubou H., Tokutomi Y., Sakata A., Tokutomi N.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 127
- Data Source
  KAKENHI-PROJECT-24501021
[Journal Article] Effects of flavonoids on proliferation of vascular smooth muscle cells and the contractile response.2013
- Author(s)
  Yoshiko TOKUTOMI, Yukari KOGA, Atsuko SAKATA, Naofumi TOKUTOMI
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 121
- Data Source
  KAKENHI-PROJECT-24501021
[Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice.2011
- Author(s)
  Tokutomi Y, et al
- Journal Title
  
  British Journal of Pharmacology 162(8)
  
  Pages: 1884-1893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice.2011
- Author(s)
  Tokutomi Y, et al.
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 162(8) Pages: 1884-1893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice.2010
- Author(s)
  Dong YF, Liu L, Lai ZF, Yamamoto E, Kataoka K, Nakamura T, Fukuda M, Tokutomi Y, et al.
- Journal Title
  
  Journal of Hypertension
  
  Volume: 28(7) Pages: 1554-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Ezetimibe ameliorates cardiovascular complications and hepatic steatosis in obese and type 2 diabetic db/db mice.2010
- Author(s)
  Fukuda M, Nakamura T, Kataoka K, Nako H, Tokutomi Y, et al.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 335(1) Pages: 70-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes.2010
- Author(s)
  Dong YF, Liu L, Kataoka K, Nakamura T, Fukuda M, Tokutomi Y, et al.
- Journal Title
  
  Diabetologia.
  
  Volume: 53(1) Pages: 180-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet.2010
- Author(s)
  Kataoka K, Tokutomi Y, et al
- Journal Title
  
  Journal of Hypertension 29(1)
  
  Pages: 76-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Vascular responses to 8-nitroguanosine 3',5'-cyclic monophosphate in nondiabetic and diabetic mice.2010
- Author(s)
  Tokutomi Y, Kataoka K, et al
- Journal Title
  
  The 6th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide.
  
  Pages: 92-92
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Potentiation by candesartan of protective effects of pioglitazone against type 2 diabetic cardiovascular and renal complications in obese mice.2010
- Author(s)
  Fukuda M, Nakamura T, Kataoka K, Nako H, Tokutomi Y, et al.
- Journal Title
  
  Journal of Hypertension
  
  Volume: 28(2) Pages: 340-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Effects of 8-nitro-cGMP on vascular responsiveness.2009
- Author(s)
  Tokutomi Y, et al
- Journal Title
  
  Journal of Pharmacological Sciences 109(Suppl)
  
  Pages: 105-105
- Data Source
  KAKENHI-PROJECT-20590255
[Journal Article] Roles of ryanodine receptor in rate capability of beating ventricular myocytes in culture.2006
- Author(s)
  Tokutomi N
- Journal Title
  
  J.of Pharmacol.Sci. 100
  
  Pages: 75-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Roles of ryanodine receptor in rate capability of beating ventricular myocytes in culture.2006
- Author(s)
  Tokutomi N.
- Journal Title
  
  Journal of Pharmacological Sciences 100
  
  Pages: 75-75
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] c-kit機能欠如マウス消化管平滑筋の薬物に対する異常反応2004
- Author(s)
  徳富直史, 他
- Journal Title
  
  日薬理誌 123・3
  
  Pages: 163-169
- NAID
  10017019128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Drug-induced anomalous contraction of gastrointestinal tract of mice with impaired c-kit function.2004
- Author(s)
  Tokutomi N, Tokutomi Y, Nishi K
- Journal Title
  
  Folia Pharmacol Jpn. 123
  
  Pages: 163-169
- NAID
  10017019128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Effects of α_1-acid glycoprotein on isometric tension of mouse aorta.2003
- Author(s)
  Tokutomi Y, Okamoto S, Matsumoto K, Otagiri M, Nishi K, Tokutomi N
- Journal Title
  
  Eur.J.Pharmacol 477・2
  
  Pages: 137-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Effects of □_1-acid glycoproctein on isometric tension of mouse aorta2003
- Author(s)
  Tokutomi Y., et al.
- Journal Title
  
  Eur.J.Pharmacol 477・2
  
  Pages: 137-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons.2003
- Author(s)
  Katsurabayashi S, Kubota H, Tokutomi N, Akaike N
- Journal Title
  
  Neuropharmacol 44
  
  Pages: 1022-1030
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Effects of α_1-acid glycoprotein on blood circulation.2003
- Author(s)
  Matsumoto K, Okamoto S, Tokutomi Y, Tokutomi N, Nishi K, Maruyama T, Suenaga A, Otagiri M
- Journal Title
  
  Artificial Blood 11・2
  
  Pages: 144-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Patent] 2.病態ならびに生体電気信号発生培養容器2006
- Inventor(s)
  徳富直史
- Industrial Property Rights Holder
  科学技術振興機構他
- Industrial Property Number
  2006-030870
- Filing Date
  2006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Patent] 病態ならびに生体電気信号発生培養容器2006
- Inventor(s)
  徳冨直史
- Industrial Property Rights Holder
  科学技術振興機構他
- Industrial Property Number
  2006-030870
- Filing Date
  2006-02-08
- Data Source
  KAKENHI-PROJECT-15590232
[Patent] 1.磁場又は電場刺激及びその…促進2005
- Inventor(s)
  徳富直史
- Industrial Property Rights Holder
  科学技術振興機構他
- Filing Date
  2005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Presentation] キイロショウジョウバエの行動解析と薬理学的応用2017
- Author(s)
  徳冨直史、他3名（4名中4番目）
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-15K00865
[Presentation] ポリフェノールの血管弛緩応答におけるCa2+活性化 K+チャネル及び電位依存性K+チャネルの役割2017
- Author(s)
  本村恵理子、徳冨芳子、徳冨直史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Year and Date
  2017-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00865
[Presentation] 免疫調節能を有する食品成分のガレクチン分子の発現に及ぼす影響2015
- Author(s)
  坂田敦子, 徳冨芳子, et al
- Organizer
  第62回日本栄養改善学会学術総会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-15K00865
[Presentation] 血管平滑筋細胞増殖および収縮応答に対するフラボノイド類の影響2013
- Author(s)
  徳冨芳子
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24501021
[Presentation] 培養ミニ心臓のリモデリングと収縮特性2010
- Author(s)
  徳冨直史,内田友二,徳冨芳子
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  かごしま県民交流センター
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20590255
[Presentation] Vascular responses to 8-nitroguanosine 3',5'-cyclic monophosphate in non-diabetic and diabetic mice.2010
- Author(s)
  Tokutomi Y, et al.
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-20590255
[Presentation] Vascular responses to 8-nitroguanosine 3',5'-cyclic monophosphate in nondiabetic and diabetic mice.2010
- Author(s)
  徳冨芳子, et al
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-20590255
[Presentation] 8-Nitro-cGMPの血管系への作用2009
- Author(s)
  徳冨芳子, et al.
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20590255
[Presentation] 8-Nitro-cGMPの血管系への作用2009
- Author(s)
  徳冨芳子
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフイコ横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20590255
[Presentation] 高脂肪食負荷マウスの血管応答に対するポリフェノールの影響
- Author(s)
  當房浩一、徳冨芳子、坂田敦子、徳冨直史
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24501021

1. TOKUTOMI Naofumi (30227582)

# of Collaborated Projects: 9 results

# of Collaborated Products: 8 results
2. NISHI Katsuhide (00040220)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results

TOKUTOMI YOSHIKO 徳冨 芳子

徳冨 芳子 トクトミ ヨシコ

TOKUTOMI Yoshiko 徳冨 芳子

徳富 芳子 トクトミ ヨシコ

Research Projects

Research Products

Co-Researchers

脂肪細胞機能制御因子を標的とした食品機能性成分によるメタボリック症候群予防の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the molecular mechanisms of effects of polyphenols on risk factors for glucose and lipid metabolic disorders aiming for the prevention of the metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the active ingredients in functional foods for risk reduction of the metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the roles for 8-nitroguanosine 3',5'-cyclic monophosphate in the cardiovascular system and the applications to drug discovery.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An experimental model for axonal regeneration in vitro and its application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Kit signalling in smooth muscle tissues

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of c-kit in development and pathophysiology of smooth musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of c-kit in functional development of Ca^<2+> release mechanism in smooth muscle cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of development of mammalian smooth mscle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of c-KIT on the development in synaptic function and CaィイD12+ィエD1 signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

平滑筋細胞の機能発達におけるC-kit陽性細胞の制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

中枢シナプス可塑性におけるc-kitチロシンキナーゼレセプターの役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Role of c-kit tyrosinekinase of physiological development of the gastrointestinal pacemaker activity

TOKUTOMI YOSHIKO 徳冨芳子

徳冨芳子トクトミヨシコ

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