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Koshikawa Nobuko  越川 信子

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KOSHIKAWA Nobuko  越川 信子

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Researcher Number 90260249
Other IDs
Affiliation (Current) 2025: 千葉県がんセンター(研究所), がんゲノムセンター がん先進治療開発研究室, 特任研究員
2025: 千葉県がんセンター(研究所), がん治療開発グループ がん先進治療開発研究室, 特任研究員
2025: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 特任研究員
Affiliation (based on the past Project Information) *help 2024: 千葉県がんセンター(研究所), がん治療開発グループ がん先進治療開発研究室, 特任研究員
2023: 千葉県がんセンター(研究所), がん治療開発グループ がん先進治療開発研究室, 主任上席研究員
2022: 千葉県がんセンター(研究所), がん先進治療開発研究室, 主任上席研究員
2019 – 2022: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 主任上席研究員
2014 – 2018: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 主席研究員 … More
2013 – 2016: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 研究員
2008 – 2011: Chiba Cancer Center (Research Institute), 研究局, 研究員
2007: 化学療法研究部, 研究員
2007: Chiba Cancer Center (Research Institute), Division of Pathology, Researcher
2006: 千葉県がんセンター(研究所), 病理研究部, 研究員
2005: Chiba Cancer Center Research Institute, Division of Pathology, Senior Investigator, 化学療法研究部, 主席研究員
2005: Chiba Cancer Center Research Institute, Dept. of Pathology, senior investigator, 病理研究部, 主席研究員
2004: 千葉県がんセンター, 病理研究部, 上席研究員
2004: 千葉県がんセンター, 病理研究部, 主席研究員
2001: Chiba Cancer Center Research Institute, Division of Pathology, Research Fellow, 病理研究部, 上席研究員
2000: 千葉県がんセンター, 研究局・病理研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Basic Section 48040:Medical biochemistry-related / Basic Section 49010:Pathological biochemistry-related / Cerebral neurosurgery / Thoracic surgery / Pathological medical chemistry / Thoracic surgery
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical genome science / General medical chemistry / Pathological medical chemistry / Tumor therapeutics
Keywords
Principal Investigator
ミトコンドリアDNA / PIポリアミド / Glioma / p53 / gene therapy / 肺がん / TNF-α / 遺伝子治療 / mtDNA 変異 / MELAS … More / ミトコンドリア病 / 病因性ミトコンドリアDNA / 変異 / mtDNA / 転移能 / 肺癌 / 浸潤 / 転移 / 癌 / 細胞間移行 / 変異mtDNA / がん増殖抑制 / TPP / malignancy / cancer / mutated mtDNA / Triphenylphosphonium / PI polyamide / SNP / 子宮癌 / 病原性mtDNA変異 / 子宮がん / PIP-TPP / DNA / ミトコンドリア / A3243G変異 / A3243G / hypoxia sensitive promoter / radiation sensitive promoter / high-LET carbon ions / p53遺伝子 / 重粒子線治療 / 低酸素増感プロモーター / 放射線増感プロモーター / 重粒子線 / グリオーマ / dendritic cells / antigen presentaion / lung metastasis / lung cancer / Fas ligand / CD40 ligand / 樹状細胞 / 樹上細胞 / 抗原提示 / 肺転移 / Fasリガンド / CD40リガンド / 疾患特異的mtDNA変異 / PI ポリアミド / PIポリアミドFITC修飾 / cybrid / mtDNA異常 / ミットコンドリア病 / ヒト腫瘍 / 神経膠芽腫 / 癌部と非癌部 / 肺癌・大腸癌 / ROS / ラマンバンド / 髄液播種 / 神経膠腫 / 転移巣 / 原発巣 / 大腸癌 / mtDNA変異 / HIF阻害 / HIF阻害剤 / 脱分化 / 低酸素 … More
Except Principal Investigator
アルキル化剤 / ピロールイミダゾールポリアミド / 膵臓がん / Hypoxia / HIF-1 / 低酸素 / KRAS / 腫瘍微小環境 / 腫瘍増殖 / アディポネクチン / 皮下移植 / マウス膵臓がん細胞株 / sST2 / IL-33 / 受精鶏卵 / MYCN / アミノ基 / PIP-CBI / hTERT / PIポリアミド / 病因生変異 / 腫瘍内微小環境 / マイトファジー / ミトコンドリア / トンネルナノチューブ / 転移 / 細胞間移行 / 細胞外小胞 / ミトコンドリアDNA / 膵線管がん / ゲノム創薬 / ゲノム医学 / ゲノム科学 / 総合生物 / KR12 / 膵線管癌 / Cancer stem cell / Tissue・Cell / Cancer / がん幹細胞 / 組織・細胞 / 癌 / Translesional DNA polymerase / Mutation / DNA polymerase ι / 不忠実DNA polymerase / 突然変異 / 分子標的治療 / 抗がん剤 / ゲノム / 薬学 / 抗生物質 / 遺伝子 / 免疫チェックポイント阻害 / マイナーグルーブバインダー / DNA配列認識化合物 / 変異遺伝子標的治療 / がんドライバー遺伝子変異 / 抗癌治療薬 / DNA副溝結合化合物 / 遺伝子変異 / ドライバー遺伝子 / がん Less
  • Research Projects

    (15 results)
  • Research Products

    (115 results)
  • Co-Researchers

    (21 People)
  •  Analysis of the role of mtDNA mutations in invasion and metastasis using mitochondrial intercellular transferPrincipal Investigator

    • Principal Investigator
      越川 信子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  膵臓がんの同所及び異所性腫瘍微小環境内IL-33応答が腫瘍増殖に及ぼす影響の解析

    • Principal Investigator
      竹永 啓三
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Exploring the potential of PIP-CBI derivatives with amino groups as anticancer agents for drug discovery

    • Principal Investigator
      WATANABE TAKAYOSHI
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Tumor growth suppression by PIP targeting against mutated mtDNAsPrincipal Investigator

    • Principal Investigator
      Koshikawa Nobuko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Analysis of the mechanism of enhancement of metastasis by pathogenic mitochondrial DNA mutation.

    • Principal Investigator
      TAKENAGA Keizo
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Development of therapeutic strategy using molecules of targeting genomic mutation for pancreatic ductal carcinoma

    • Principal Investigator
      Watanabe Takayoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical genome science
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Target therapy of pathogenic mtDNA mutation with PI polyamidePrincipal Investigator

    • Principal Investigator
      Koshikawa Nobuko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Development of Alkylating PI polyamides targeting oncogenic driver gene mutations

    • Principal Investigator
      Nagase Hiroki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Study of mitochondria-associated diseases by pathogenic mitochondrial DNA replication delayPrincipal Investigator

    • Principal Investigator
      Koshikawa Nobuko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Comparison of the frequency of mtDNA mutation in primary and metastatic lesions of human malignant tumorsPrincipal Investigator

    • Principal Investigator
      KOSHIKAWA Nobuko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Effect of HIF inhibitors on tumor hypoxia-induced dedifferentiation and metastasis of lung carcinoma cellsPrincipal Investigator

    • Principal Investigator
      KOSHIKAWA Nobuko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Analysis of the effects of tumor hypoxia on dynamics of cancer stem cells

    • Principal Investigator
      KEIZO Takenaga
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Biological role of the regulation of the expressions of transpersonal DNA polymereases by hypoxia

    • Principal Investigator
      TAKENAGA Keizo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Chiba Cancer Center Research Institute
  •  Cell-cidal effect of the combination therapy of p53 gene under the control of radiation- and hypoxia-sensitized promoter and heavy particle irradiation in gliomaPrincipal Investigator

    • Principal Investigator
      KOSHIKAWA Nobuko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Chiba cancer center research institute
  •  Forced expression of the TNF-family gene in lung cancer cells produced therapeutic effects, stimulating antigen-presentation processes.Principal Investigator

    • Principal Investigator
      KOSHIKAWA Nobuko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Chiba Cancer Center Research Institute

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Patent Other

  • [Journal Article] Suppression of NSCLC A549 tumor growth by a mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐TPP and a senolytic drug2022

    • Author(s)
      Tsuji Kohei、Kida Yuki、Koshikawa Nobuko、Yamamoto Seigi、Shinozaki Yoshinao、Watanabe Takayoshi、Lin Jason、Nagase Hiroki、Takenaga Keizo
    • Journal Title

      Cancer Science

      Volume: - Issue: 4 Pages: 1321-1337

    • DOI

      10.1111/cas.15290

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-22H04923
  • [Journal Article] Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells2022

    • Author(s)
      Yao Jihang、Takenaga Keizo、Koshikawa Nobuko、Kida Yuki、Lin Jason、Watanabe Takayoshi、Maru Yoshiaki、Hippo Yoshitaka、Yamamoto Seigi、Zhu Yuyan、Nagase Hiroki
    • Journal Title

      International Journal of Cancer

      Volume: 152 Issue: 5 Pages: 962-976

    • DOI

      10.1002/ijc.34319

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08019, KAKENHI-PROJECT-21K09506, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-21K14756, KAKENHI-PROJECT-22H04923
  • [Journal Article] Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma2022

    • Author(s)
      Tsujimoto Akiko、Matsuo Niina、Lai Xiaoyi、Inoue Takahiro、Yoda Hiroyuki、Lin Jason、Shinozaki Yoshinao、Watanabe Takayoshi、Koshikawa Nobuko、Takatori Atsushi、Nagase Hiroki
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 5 Pages: 5821-5832

    • DOI

      10.1002/cam4.5359

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07710
  • [Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer2021

    • Author(s)
      Nagase Hiroki、Watanabe Takayoshi、Koshikawa Nobuko、Yamamoto Seigi、Takenaga Keizo、Lin Jason
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 12 Pages: 4834-4843

    • DOI

      10.1111/cas.15143

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710
  • [Journal Article] A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation2021

    • Author(s)
      N.Koshikawa N.Yasui Y.Kida Y.Shinozaki K.Tsuji T.Watanabe K.Takenag H.Nagase
    • Journal Title

      Cancer Science

      Volume: 未 Issue: 6 Pages: 1-9

    • DOI

      10.1111/cas.14912

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-20H03540
  • [Journal Article] Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles2021

    • Author(s)
      Takenaga Keizo、Koshikawa Nobuko、Nagase Hiroki
    • Journal Title

      BMC Molecular and Cell Biology

      Volume: 22 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s12860-021-00391-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654
  • [Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021

    • Author(s)
      Koshikawa Nobuko、Kida Yuki、Yasui Nanami、Shinozaki Yoshinao、Tsuji Kohei、Watanabe Takayoshi、Lin Jason、Yamamoto Seigi、Takenaga Keizo、Nagase Hiroki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 576 Pages: 93-99

    • DOI

      10.1016/j.bbrc.2021.08.088

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710
  • [Journal Article] Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.2016

    • Author(s)
      Lin J, Hiraoka K, Watanabe T, Kuo T, Shinozaki Y, Takatori A, Koshikawa N, Chandran A, Otsuki J, Sugiyama H, Horton P and Nagase H.
    • Journal Title

      PlosOne

      Volume: 11 Issue: 10 Pages: e0165581-e0165581

    • DOI

      10.1371/journal.pone.0165581

    • NAID

      120005997725

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K05486, KAKENHI-ORGANIZER-25112001
  • [Journal Article] Double beta-alanine substitutions incorporated in 12-ring pyrrole-Imidazole Polyamides for lengthened DNA minor groove recognition.2016

    • Author(s)
      Watanabe T, Shinohara K, Shinozaki Y, Uekusa S, Wang X, Koshikawa N, Hiraoka K, Inoue T, Lin J, Bando T, Sugiyama H and Nagase H.
    • Journal Title

      Advanced Techniques in Biology & Medicine.

      Volume: 4 Issue: 02 Pages: 175-175

    • DOI

      10.4172/2379-1764.1000175

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001
  • [Journal Article] Double β-alanine substitutions incorporated in 12-ring pyrrole-Imidazole Polyamides for lengthened DNA minor groove recognition.2016

    • Author(s)
      Watanabe T, Shinohara K, Shinozaki Y, Uekusa S, Wang X, Koshikawa N, Hiraoka K, Inoue T, Lin J, Bando T, Sugiyama H and Nagase H.
    • Journal Title

      Advanced Techniques in Biology & Medicine.

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Journal Article] Identification of a novel E-box binding PI polyamide inhibiting MYC-driven cell-proliferation.2015

    • Author(s)
      Mishra R, Watanabe T, Kimura M, Koshikawa N, Ikeda M, Uekusa S, Kawashima H, Wang X, Igarashi J, Choudhury D, Grandori C, Kemp C, Ohira M, Verma N, Kobayashi Y, Takeuchi J, Koshinaga T, Nemoto N, Fukuda N, Soma M, Kusafuka T, Fujiwara K, Nagase H.
    • Journal Title

      Cancer Science

      Volume: 106(4) Issue: 4 Pages: 421-429

    • DOI

      10.1111/cas.12610

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
  • [Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets E-box.2014

    • Author(s)
      134. Taniguchi M, Nakai Y, Ozaki T, Koshikawa N, Kojima T, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma T, Nagase H.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 328-334

    • DOI

      10.1016/j.fob.2014.03.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300344, KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-23501313, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
  • [Journal Article] Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.2014

    • Author(s)
      Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
    • Journal Title

      Nat. Commun.

      Volume: 6 Issue: 1 Pages: 6706-6706

    • DOI

      10.1038/ncomms7706

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-25461573, KAKENHI-PROJECT-24310155, KAKENHI-PROJECT-24225005
  • [Journal Article] MCL-1V, a novel mouse antiapoptotic MCL-l variant, generated by RNA splicing at a non-canonical splicing pair.2010

    • Author(s)
      Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 391 Pages: 492-497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Journal Article] Reactive oxygen speciesgenerating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1 alpha gene transcription via phosphatid ylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway2009

    • Author(s)
      Koshikawa N, Hayashi J, Nakagawara A, Takenaga K
    • Journal Title

      Journal of Biological Chemistry

      Volume: 284 Pages: 33185-33194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Journal Article] MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair2009

    • Author(s)
      Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K
    • Journal Title

      Biochem Biophys Res Common. 391

      Pages: 492-497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Journal Article] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-lalpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway2009

    • Author(s)
      Koshikawa N, Hayashi J, Nakagawara A, Takenaga K
    • Journal Title

      Joarnal of Biological Chemistry 284

      Pages: 33185-33194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Journal Article] MCL-1V, a novel m ouse antiapoptotic MCL-1 variant, genera ted byRNA splicing at a non-canonical splicing pair2009

    • Author(s)
      Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K
    • Journal Title

      Biochem BiophysRes Comun3

      Volume: 91 Pages: 492-497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Journal Article] Reversible regulation of metastasis by ROS-generating mtDNA mutations2008

    • Author(s)
      Ishikawa K, Koshikawa N, Takenaga K, Nakada K, Hayashi J.
    • Journal Title

      Mitochondrion 8

      Pages: 339-344

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Journal Article] Enhance glycolysis induced by mtDNA mutations does not regulate metastasis2008

    • Author(s)
      Ishikawa K, Hashizume O, Koshikawa N, Fukuda S, Nakada K, Takenaga K, Hayashi J.
    • Journal Title

      FEBS Letter 582

      Pages: 3525-3530

    • NAID

      120007138501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Journal Article] ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis2008

    • Author(s)
      Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H,Nakada K, HonmaY, Hayashi J
    • Journal Title

      Science 320

      Pages: 661-664

    • NAID

      120007138465

    • Data Source
      KAKENHI-PROJECT-19591655
  • [Journal Article] Reversible re- gulation of metastasis by ROS- generating mtDNA mutations2008

    • Author(s)
      Ishikawa K, Koshikawa N, Takenaga K, Nakada K, Hayashi J
    • Journal Title

      Mito- chondrion, 8

      Pages: 339-344

    • Data Source
      KAKENHI-PROJECT-19591655
  • [Journal Article] Enhance glycolysis induced by mtDNA mutations does not regulate metastasis2008

    • Author(s)
      Ishikawa K, Hashizume O, Koshikawa N, Fukuda S, Nakada K, Takenaga K, Hayashi J
    • Journal Title

      FEBS Letter 582

      Pages: 3525-3530

    • NAID

      120007138501

    • Data Source
      KAKENHI-PROJECT-19591655
  • [Journal Article] HayashiJ-I. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.2008

    • Author(s)
      Ishikawa K, Takenaga K. Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y
    • Journal Title

      Science 320

      Pages: 661-664

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Journal Article] ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis2008

    • Author(s)
      Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J.
    • Journal Title

      Science 320

      Pages: 661-664

    • NAID

      120007138465

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Journal Article] ROS-generating mitochondrial KNA mutations can regulate tumor cell metastasis2008

    • Author(s)
      Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J-I
    • Journal Title

      Science 320

      Pages: 661-664

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Journal Article] 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositidr 3-kinases independently of autophagy inhibition.2007

    • Author(s)
      Ito S., Koshikawa N, Mochizuki S, Takenaga K
    • Journal Title

      Int. J. Oncology 31

      Pages: 261-268

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Journal Article] 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositidr 3-kinases independently of autophagy inhibition.2007

    • Author(s)
      Ito S., Koshikawa N, Mochizuki S, Takenaga K.
    • Journal Title

      Int. J. Oncology 31

      Pages: 261-268

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Journal Article] Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors.2006

    • Author(s)
      N.Koshikawa, et al.
    • Journal Title

      Oncogene 25

      Pages: 917-928

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590257
  • [Journal Article] Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors.2006

    • Author(s)
      N.Koshikawa
    • Journal Title

      oncogene 25

      Pages: 313-321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591466
  • [Journal Article] Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors.2006

    • Author(s)
      Koshikawa N, Takenaga K. et al.
    • Journal Title

      Oncogene 25

      Pages: 917-928

    • Data Source
      KAKENHI-PROJECT-16590257
  • [Journal Article] Hypoxia-inducible factor-1 mediates the expression of DNA polymerase iota.2006

    • Author(s)
      Ito A, Koshikawa N, Mochizuki S, Omura K, Takenaga K
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 306-311

    • Data Source
      KAKENHI-PROJECT-18590280
  • [Journal Article] Hypoxia selects for high-metastatic Lewis lung caecinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors.2006

    • Author(s)
      N.Koshikawa
    • Journal Title

      Oncpgene 25

      Pages: 917-928

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590257
  • [Journal Article] Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors.2006

    • Author(s)
      Koshikawa N, Maejima C, Miyazaki K, Nakagawara A, Takenaga K.
    • Journal Title

      Oncogene 25・6

      Pages: 917-928

    • Data Source
      KAKENHI-PROJECT-16591466
  • [Journal Article] Hypoxia-inducible factor-l mediates the expression of DNA polymerase2006

    • Author(s)
      Ito A, Koshikawa N, Mochizuki S., Omura K, Takenaga K.
    • Journal Title

      Biochem Biophys Res Commun 351

      Pages: 306-311

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Journal Article] Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors.2006

    • Author(s)
      N.Koshikawa, C.Maejima, K.Miyazaki, A.Nakagawara, K.Takenaga.
    • Journal Title

      Oncogene. 25

      Pages: 917-928

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591466
  • [Journal Article] Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia- inducible factor-1 α oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor.2005

    • Author(s)
      N.Koshikawa, et al.
    • Journal Title

      Cancer Research. 65

      Pages: 11622-11630

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590257
  • [Journal Article] Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-lalpha oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor.2005

    • Author(s)
      Koshikawa N, Takenaga K.
    • Journal Title

      Cancer Ressearch 65・24

      Pages: 11622-11630

    • Data Source
      KAKENHI-PROJECT-16591466
  • [Journal Article] Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1 alpha oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor.2005

    • Author(s)
      N.Koshikawa, K.Takenaga.
    • Journal Title

      Cancer Research 65

      Pages: 11622-11630

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591466
  • [Journal Article] Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1 α oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor.2005

    • Author(s)
      Koshikawa N, Takenaga K.
    • Journal Title

      Cancer Res. 65

      Pages: 11622-11630

    • Data Source
      KAKENHI-PROJECT-16590257
  • [Journal Article] Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-lalpha oxygen-dependent degradatiott domain preferentially induces apoptosis ofhypoxic cells in solid tumor.2005

    • Author(s)
      N.Koshikawa
    • Journal Title

      Cancer Research 65

      Pages: 11622-1130

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591466
  • [Journal Article] Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1 α oxygen-dependent degradation domain preferentially indeces spoptosis of hypoxic cells in solid tumor.2005

    • Author(s)
      N.Koshikawa
    • Journal Title

      Cancer Research 65

      Pages: 11622-11630

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590257
  • [Patent] 二重膜構造細胞内小器官DNA標的薬2019

    • Inventor(s)
      永瀬浩喜 渡部隆義 越川信子 安井七海
    • Industrial Property Rights Holder
      千葉県
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Patent] 二重膜構造細胞内小器官DNA標的薬2019

    • Inventor(s)
      永瀬浩喜 越川信子 渡部隆義 安井七海
    • Industrial Property Rights Holder
      千葉県
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-16K09978
  • [Presentation] マウス膵臓がん細胞におけるIL-33デコイ受容体sST2の発現低下は皮下腫瘍の増殖を促進する2024

    • Author(s)
      秋元 美穂、越川 信子、安達 三美、竹永 啓三
    • Organizer
      第83回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K06644
  • [Presentation] Growth inhibition of cancer cells by TPP-conjugated DNA gyrase inhibitors through suppression of mtDNA replication2023

    • Author(s)
      喬 昱銘、木田 裕貴、越川 信子、竹永 啓三
    • Organizer
      第36回国際哺乳類ゲノム会議
    • Data Source
      KAKENHI-PROJECT-19K07654
  • [Presentation] TPP結合DNAジャイレース阻害剤によるmtDNA複製阻害を介したがん細胞の増殖阻害2022

    • Author(s)
      喬 昱銘、木田 裕貴、越川 信子、竹永 啓三
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07654
  • [Presentation] DNAジャイレース阻害剤ーTPP複合体によるmtDNA複製阻害を介した癌細胞の細胞死の誘導2022

    • Author(s)
      喬いく銘、木田裕貴、越川信子、竹永啓三
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] TPP 結合 DNA ジャイレース阻害剤による mtDNA 複製阻害を介し たがん細胞の増殖阻害2022

    • Author(s)
      喬 いく銘、木田 裕貴、渡部 隆義、越川 信子、竹永 啓三
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07710
  • [Presentation] 非小細胞肺癌を標的とした変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用療法の開発2021

    • Author(s)
      山本清義、越川信子、木田裕貴、渡部隆義、Lin Jason、竹永啓三、永瀬浩喜
    • Organizer
      先端モデル動物支援 若手支援技術講習会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021

    • Author(s)
      山本清義、辻航平、越川信子、木田裕貴、渡辺隆義、リン ジェイソン、竹永啓三、永瀬浩喜
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021

    • Author(s)
      山本清義、越川信子、木田裕貴、渡部隆義、Lin Jason、竹永啓三、永瀬浩喜
    • Organizer
      第80回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] Characterization of Cancer Genome-wide Binding of Pyrrole-Imidazole Polyamide-Vorinostat Conjugates by Machine Learning2021

    • Author(s)
      J. Lin, I.Hosoya, S. Sakuma, Y, Kida, T, Watanabe, S. Yamamoto, A. Takatori, N. Koshikawa, H. Nagase
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] DNAジャイレース阻害剤ーTPP複合体によるmtDNA複製阻害を介した癌細胞のアポトーシスの誘導2021

    • Author(s)
      喬いく銘、木田裕貴、越川信子、竹永啓三、永瀬浩喜
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] ミトコンドリアDNA変異を標的にした薬剤候補によるがん細胞老化、細胞死、老化細胞除去誘導2020

    • Author(s)
      永瀬浩喜、越川信子、山本清義、辻航平、木田裕貴、竹永啓三
    • Organizer
      日本癌学会学術総会(第79回)
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] mtDNAを標的としたPIポリアミド-TPPによるA549肺がん細胞の細胞老化と老化細胞除去の誘導2020

    • Author(s)
      辻 航平、竹永 啓三、木田 裕貴、越川 信子、永瀬 浩喜
    • Organizer
      日本癌学会学術総会(第79回)
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] mtDNA変異を標的としたPyrrole-Imidazole-Polyamide修飾化合物による腫瘍増殖抑制効果の検討2019

    • Author(s)
      辻航平、越川信子、竹永啓三、永瀬浩喜
    • Organizer
      第42回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] Retardation of Tumor cell growth by PI polyamide-drug conjugates targeting mtDNA mutation2019

    • Author(s)
      Nobuko Koshikawa, Kohei Tsuji, Keizo Takenaga, Hiroki Nagase
    • Organizer
      The 24th JFCR-ISCC Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] A strategy for therapeutic targeting in pathological cells with mutant mitochondrial DNA using mitochondria targeted minor grove binders2019

    • Author(s)
      Nagase H, Koshikawa N et al
    • Organizer
      ASGCT 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] がん細胞が遊離する細胞外小胞にはミトコンドリアDNAが包含される2019

    • Author(s)
      竹永啓三、越川信子、永瀬浩喜
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07654
  • [Presentation] 細胞外小胞を介した細胞間ミトコンドリアDNA移行2019

    • Author(s)
      竹永啓三、越川信子、永瀬浩喜
    • Organizer
      第17回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-19K07654
  • [Presentation] 肺癌における転移促進性mtDNA ND遺伝子変異による乳酸トランスポーターMCT4の特異的発現促進2019

    • Author(s)
      竹永啓三、越川信子、永瀬浩喜
    • Organizer
      第28回日本癌病態治療研究会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] ヒトテロメラーゼ逆転写酵素(hTERT)を標的としたアルキル化PDCによる治療戦略の構築2019

    • Author(s)
      渡部 隆義、高取 敦史、養田 裕行、越川 信子、Lin Jason、篠崎 喜脩、永瀬 浩喜
    • Organizer
      第28回日本癌病態治療研究会
    • Data Source
      KAKENHI-PROJECT-17K07259
  • [Presentation] 肺癌における転移促進性mtDNA ND遺伝子変異による乳酸トランスポーターMCT4の特異的発現促進2019

    • Author(s)
      越川信子、竹永啓三、永瀬浩喜
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] mtDNA変異を標的にした修飾PIポリアミドによるROS産生亢進と細胞増殖の抑制2019

    • Author(s)
      佐久間誠、辻航平、渡部隆義、越川信子、竹永啓三、永瀬浩喜
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07408
  • [Presentation] hTERT 遺伝子を標的とした PIP 化合物と抗癌活性の向上を指向した誘導体の開発2019

    • Author(s)
      渡部 隆義、高取 敦志、養田 裕行、越川 信子、篠崎 喜脩、永 瀬 浩喜
    • Organizer
      第78回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K07259
  • [Presentation] PIポリアミド修飾化合物によるミトコンドリア標的遺伝子配列のコピース数減少の検討2018

    • Author(s)
      安井七海・越川信子・渡部隆義・篠崎喜脩・高取敦志・Jason Lin・永瀬浩喜
    • Organizer
      第27回癌病態治療研究会
    • Data Source
      KAKENHI-PROJECT-16K09978
  • [Presentation] TPP修飾新規PIポリアミドによる変異mtDNA含有細胞の細胞死の特異的誘導2018

    • Author(s)
      越川信子・竹永啓三・篠崎喜脩・安井七海・永瀬浩喜
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K09978
  • [Presentation] TPPを用いたピロールイミダゾールポリアミドのミトコンドリアDNAへの導入とDNA複製への影響2018

    • Author(s)
      安井七海・越川信子・渡部隆義・篠崎喜脩・高取敦志・リン ジェイソン・竹永啓三・永瀬浩喜
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K09978
  • [Presentation] PIポリアミドによる病因性ミトコンドリアDNA変異関連疾患の治療2017

    • Author(s)
      越川信子
    • Organizer
      ConBio2017
    • Data Source
      KAKENHI-PROJECT-16K09978
  • [Presentation] 膵腺管癌におけるKRAS 変異を標的にしたKR122017

    • Author(s)
      松尾仁以奈、井上貴博、養田祐行、高取敦志、篠崎喜脩、渡部隆義、越川信子、ジェイソンリン、永瀬浩喜
    • Organizer
      第76回日本癌学会学術総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07259
  • [Presentation] ・ピロールイミダゾールポリアミドによる大腸がんドライバー遺伝子標的治療薬の開発2016

    • Author(s)
      永瀬浩喜、越川信子
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      大分県別府市
    • Year and Date
      2016-05-31
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] Pyrrole-Imidazole polyamide conjugates targeting the cancer genome2016

    • Author(s)
      Hiroki Nagase, Atsushi Takatori Takayoshi Watanabe, Nobuko Koshikawa, Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Jason Lin, Yoshinao Shinozaki, Krishnamurthy Sakthisri, Nina Matsuo, Asuka Hattori
    • Organizer
      第89回 日本生化学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] ・Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations2016

    • Author(s)
      Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Krishnamurthy Sakthisri, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      ニューオリンズ 米国
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] ・MYCN遺伝子を標的としたPIポリアミドDNAアルキル化剤の抗腫瘍活性と安全性2016

    • Author(s)
      高取敦志、養田裕行、井上貴博、渡部隆義、越川信子、若菜茂晴、永瀬浩喜
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Place of Presentation
      東京都品川
    • Year and Date
      2016-12-15
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] Chem-seq:identifying genomic binding sites of a pyrrole-imidazole polyamide by nxt-generation sequencing2016

    • Author(s)
      Lin Jason,Hiraoka Kiriko,Watanabe takayoshi,kuo Tony, Shinozaki Yoshinao,Takatori Atsushi,Koshikawa Nobuko,Otsuki Joe,Sugiyama Hiroshi,Horton Paul,Nagase Hiroki
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] ・Comprehensive genetic analysis for the anticancer activity of a novel alkylating targeting KRAS mutation2016

    • Author(s)
      平岡桐子、Lin Jason、阿久澤夏樹、井上貴博、養田裕行、Krishnamurty Sakthise、渡部隆義、高取敦志、越川信子、尾崎俊文、永瀬浩喜
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] Tumor accumulation of a novel alkylating pyrrole-imidazole polyamide (KR12) targeting KRAS codon 12 mutations in murine xenograft models of human colon cancer2015

    • Author(s)
      Takahiro Inoue, Kiriko Hiraoka, Yusei Suzuki, Hiroyuki Yoda, Takayoshi Watanabe, Atsushi Takatori, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase.
    • Organizer
      AACR American Association for Cancer Research ANUAL MEETING 2015  ミニシンポジウム Exploiting the MAPK pathway in cancer
    • Place of Presentation
      フィラデルフィア 米国
    • Year and Date
      2015-04-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] 神経芽腫に対するPIポリアミドDNAアルキル化剤複合体を用いた治療戦略2015

    • Author(s)
      養田裕行,高取敦志,井上貴博,渡部隆義,越川信子,尾崎俊文,永瀬浩喜
    • Organizer
      日本小児血液・がん学会
    • Place of Presentation
      甲府
    • Year and Date
      2015-11-27
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] 変異型 KRAS 遺伝子を標的とした塩基配列特異的アルキル化剤の大腸癌細胞における抗腫瘍効果.2015

    • Author(s)
      平岡桐子、井上貴博、養田裕行、Krishnamurty Sakthisri、高取敦志、篠原憲一 、渡部隆義、越川信子、尾崎俊文、永瀬浩喜
    • Organizer
      第24回癌病態治療研究会 ワークショップ
    • Place of Presentation
      日光
    • Year and Date
      2015-06-25
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] KRAS mutation specific alkylating pyrrole-imidazole polyamide (KR12) suppresses mutant KRAS expression and inhibits tumor growth by showing accumulation in KRAS mutant xenografts2015

    • Author(s)
      T Inoue,K Hiraoka, Y Suzuki, H Yoda, A Takatori, N Koshikawa, T Ozaki, H Nagase
    • Organizer
      America Association for Cancer Research Annual Meeting 2015
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-04-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461573
  • [Presentation] KRAS遺伝子G12DおよびG12V 変異DNA配列を標的にした大腸がん治療薬の開発2015

    • Author(s)
      永瀬浩喜. 平岡桐子、井上貴博、養田裕行、Krishnamurty Sakthisri、高取敦志、篠原憲一 、渡部隆義、越川信子、尾崎俊文、
    • Organizer
      第74回 日本癌学会 腫瘍別シンポジウム 1 大腸がんにおける標的分子と治療開発
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] PIポリアミド薬物複合体のMYCN遺伝子増幅難治性神経芽腫に対する革新的治療戦略への応用2015

    • Author(s)
      養田裕行、高取敦志、井上貴博、渡部隆義、越川信子、尾崎俊文、永瀬浩喜
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] A novel alkylating pyrrole-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death2015

    • Author(s)
      Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase.
    • Organizer
      AACR American Association for Cancer Research ANUAL MEETING 2015  ミニシンポジウム Exploiting the MAPK pathway in cancer
    • Place of Presentation
      フィラデルフィア 米国
    • Year and Date
      2015-04-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] A novel alkylating pyrrole-imidazole polyamide, KR12, specifically recognized mutant KRAS genes and potently induces cell death2015

    • Author(s)
      K Hiraoka, T Inoue, H Yoda, A Takatori, T Watanabe, N Koshikawa, T Ozaki, H Nagase
    • Organizer
      America Association for Cancer Research Annual Meeting 2015
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-04-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461573
  • [Presentation] Inhibition of KRAS mutant colon cancer using a novel DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting KRAS Codon12 Mutant DNA2015

    • Author(s)
      Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori.
    • Organizer
      3rd International Conference of Federation of Asian Clinical Oncology(FACO)
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2015-10-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] ヒト肺癌及び大腸癌の原発巣と転移巣におけるmtDNA変異頻度2010

    • Author(s)
      越川信子、木村秀樹、飯笹俊彦、井内俊彦、滝口伸浩、竹永啓三、中川原章
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-30
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Presentation] ヒト肺がんおよび大腸がんの原発巣と転移巣におけるmtDNA変異頻度の比較2009

    • Author(s)
      越川信子、木村秀樹、飯笹俊彦、井内俊彦、滝口伸浩、秋元美穂、本間良夫、竹永啓三
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Presentation] ヒト肺がんおよび大腸がんの原発巣と転移巣におけるmtDNA変異頻度の比較2009

    • Author(s)
      越川信子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-21590349
  • [Presentation] マウス由来細胞株および組織で発現する新規MCL-1バリアントの同定2008

    • Author(s)
      小嶋彰吾、百武明、越川信子、竹永啓三
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] ROS産生を伴うミトコンドリアDNA突然変異によるヒトがん細胞の転移能の制御2008

    • Author(s)
      越川信子、石川香、今西秦赳、中田和人、林純一、竹永啓三
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] HIF-2αによる幹細胞マーカーCD133遺伝子の発現制御2008

    • Author(s)
      望月重信、越川信子、原口清輝、中川原章、竹永啓三
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] Expression of cancer stem cell-related genes in hypoxia-resistant human lung adenocarcinoma A549 cells.2007

    • Author(s)
      Mochizuki S, Koshikawa N, Ohira M, Haraguchi S, Nakagawara A, Takenaga K.
    • Organizer
      The 66th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Expression of cancer stem cell-related genes in hypoxia-resistant human lung adenocarcinoma A549 cells.2007

    • Author(s)
      S.Mochizuki, N.Koshikawa, M.Ohira, S.Haraguchi, A.Nakagawara, K.Takenaga.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] J-I. Enhancement of metastatic potential by a pathogenic missense mutation in mitochondrial ND6 gene.2007

    • Author(s)
      Takenaga K, Ishikawa K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Homa Y, Hayashi
    • Organizer
      The 16th Annual Meeting of The Japanese Association of Metastasis Research
    • Place of Presentation
      Toyama
    • Year and Date
      2007-07-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] ミトコンドリアND6遺伝子の病因性ミッセンス変異による転移能の亢進2007

    • Author(s)
      竹永啓三、石川 香、秋元美穂、越川信子、山口 綾、今西泰赳、中田和人、本間良夫、林 純一
    • Organizer
      第16回日本がん転移学会総会
    • Place of Presentation
      富山
    • Year and Date
      2007-07-09
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] Reversible control of metastasis by a pathogenic mtDNA mutation in ND62007

    • Author(s)
      Koshikawa N, et. al.
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Reversible control of metastasis by a pathogenic mtDNA mutation in ND62007

    • Author(s)
      Koshikawa N, Ishikawa K, Akimoto M, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J-I, Takenaga K
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] Expression of cancer stem cell-related genes in hypoxia-resistant human lung adenocarcinoma A549 cells.2007

    • Author(s)
      S.Mochizuki, N.Koshikawa, M.Ohira, S.Haraguchi, A.Nakaga wara, K.Takenaga
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Expression of cancer stem cell-related genes in hypoxia-resistant human lung adenocarcinoma A549 cells2007

    • Author(s)
      Mochizuki S, Koshikawa N, Ohira M, Haraguchi S, Nakagawara A, Takenaga, K
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19591655
  • [Presentation] Reversible control of metastasis by a pathogenic mtDNA mutation in ND6.2007

    • Author(s)
      Koshikawa N, Ishikawa K, Akimoto M, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J-I, Takenaga K.
    • Organizer
      The 66th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Effects of hypoxia on the expressions of differentiation- and stem cell-related genes in human lung carcinoma A549 cells.2006

    • Author(s)
      Takenaga K, Koshikawa N, Mochizuki S, Takenobu H, Ohira M.
    • Organizer
      The 65th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Cell-cidal effedct of the combination therapy of radio- and hypoxia-sensitized promoter-regulated p53 gene and heavy particle irradiation in glioma cells.2006

    • Author(s)
      Oga M, Koshikawa N, Nojima K, Takenaga K.
    • Organizer
      The 66th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Induction of PDLIM2 gene expression by hypoxia and its role in cell motility and invasion of tumor cells.2006

    • Author(s)
      Ito S, Koshikawa N, Mochizuki S, Ohira M, Nakagawara A, Harigaya K, Takenaga K.
    • Organizer
      The 65th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] ヒト乳癌細胞株における転移抑制遺伝子nm23-H1発現の低酸素による抑制.2006

    • Author(s)
      越川信子, 他
    • Organizer
      第65回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Hypoxia stimulates dedifferentiation and metastatic potential of human lung carcinoma cells.2006

    • Author(s)
      Takenaga K, Koshikawa N, Mochizuki S, Takenobu H, Ohira M, Hori H, Nagasawa H, Uto Y.
    • Organizer
      The 4th Annual Meeting of The Japanese Association of Cancer and Hypoxia Research
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Hypoxia-response gene product NEDL1 degrades Dishevelled-1 and inhibits Dishevelled-l-stimulated differentiation of neuroblastoma cells.2006

    • Author(s)
      Mochizuki S, Koshikawa N, Ohira M, Nakagawara A, Takenaga K.
    • Organizer
      The 65th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] Hypoxia suppresses the expression of metastasis suppressor nm23-H1 gene in humanmammary. Carcinoma cells.2006

    • Author(s)
      Koshikawa N, Hori H, Nagasawa H, Uto Y, Takenaga K.
    • Organizer
      The 65th Annual Meeting of The Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590280
  • [Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤によるヒト大腸癌細胞移植マウスの抗腫瘍効果

    • Author(s)
      ・井上貴博、平岡桐子、養田裕行、丸喜明、杉本博一、篠原憲一、渡部隆義、高取敦志、越川信子、板東俊和、杉山弘、尾崎俊文、永瀬 浩喜
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] がんドライバーミューテーション特異的アルキル化剤の開発

    • Author(s)
      ・永瀬浩喜、平岡桐子、井上貴博、越川信子、渡部隆義
    • Organizer
      第28回 モロシヌス研究会
    • Place of Presentation
      修善寺
    • Year and Date
      2014-06-27 – 2014-06-28
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] A novel anti-cancer agent of DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting KRAS Codon 12 Mutant DNA

    • Author(s)
      ・Hiroki nagase, Kiriko Hiraoka, Takahiro Inoue, Nobuko Koshikawa, Takayoshi Watanabe
    • Organizer
      52st JSCO 2014 International Session Anti cancer agen
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-28 – 2014-08-30
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] KRASコドン12変異を標的とした分子標的アルキル化剤

    • Author(s)
      永瀬浩喜、平岡桐子、井上貴博、越川信子、渡部隆義
    • Organizer
      第18回日本癌分子標的治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] Allele-specific knock-down of KRAS mutations in cancers by using a novel alkylating Pyrrole-Imidazole Polyamide (KR12)

    • Author(s)
      ・Atsushi Takatori, AKiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori. and Hiroki Nagase
    • Organizer
      The 28th International Mammalian Genome Conference.
    • Place of Presentation
      Bar Harbor, USA
    • Year and Date
      2014-10-26 – 2014-10-29
    • Data Source
      KAKENHI-PROJECT-26290060
  • [Presentation] Precision Medicineを目指したオンコジェニックドライバーを標的とした治療

    • Author(s)
      ・永瀬浩喜、平岡桐子、井上隆博、渡部隆義、越川信子、尾崎俊文
    • Organizer
      第23回癌病態治療研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2014-06-12 – 2014-06-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290060
  • []

  • 1.  TAKENAGA Keizo (80260256)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 60 results
  • 2.  WATANABE Takayoshi (60526060)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 32 results
  • 3.  NAGASE Hiroki (90322073)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 47 results
  • 4.  高取 敦志 (40455390)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 5.  OHIRA Miki (20311384)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  HAYASHI Jun-ichi (60142113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  FUJISAWA Takehiko (80110328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  IIZASA Toshihiko (10272303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NOJIMA Kumie (90218272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  IWADATE Yasuo (70272309)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TAKENOBU Hisanori (60392247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  田川 雅敏 (20171572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  篠崎 喜脩 (00766553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  丸 喜明 (30742754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  秋元 美穂 (60437556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  市川 美紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 17.  山本 清義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 18.  LIN JASON
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 19.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  篠原 隆司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  筆宝 義隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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