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Kumagai Yumi  熊谷 由美

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熊谷 由美  クマガイ ユミ

KUMAGAI Yumi  熊谷 由美

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Researcher Number 90277591
Other IDs
Affiliation (Current) 2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2025: 順天堂大学, 医学部, 助教
2019 – 2023: 順天堂大学, 医学部, 助教
2012: 大阪大学, 微生物病研究所, 特任講師
1998 – 2000: 日本歯科大学, 歯学部, 助手
1995 – 1996: 日本歯科大学, 歯学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 49050:Bacteriology-related / Bacteriology (including Mycology) / Morphological basic dentistry
Except Principal Investigator
Basic Section 49050:Bacteriology-related / Morphological basic dentistry / Bacteriology (including Mycology)
Keywords
Principal Investigator
レポーターマウス / LL-37 / 好中球 / 細胞外小胞 / 敗血症 / エクトソーム / CXCR2 / FPR2 / CRAMP / lactoferrin … More / 抗菌活性分子 / ectosome / 抗菌活性 / カルパイン / Ca2+シグナリング / マイクロベシクル / 生体防御ペプチドLL-37 / シグナル伝達経路 / 抗菌作用 / 2成分制御系 / ブタレンサ球菌 / 歯周病 / 成人性歯周炎 / 病原性 / ヘモリシン … More
Except Principal Investigator
LL-37 / 生体防御ペプチド / 敗血症 / dipeptidyl aminopeptidase IV / DPPIV / Porphyromonas gingivalis / virulence / 細胞老化 / senolysis / 老化細胞除去 / SASP / 老化細胞 / マイクロRNA / 抗菌ペプチド / 細胞外小胞 / エクトソーム / エクソソーム / fibronectin / gelatinase / tissue destruction / adult periodontitis / DPPIV(dipeptidyl aminopeptidase IV) / フィブロネクチン / ゼラチナーゼ / 組織破壊 / ビルレンス / 成人性歯周炎 / molecular genetics / Porphyromonas / protease / 病原性 / 分子遺伝学 / ポルフィロモナス / プロテアーゼ Less
  • Research Projects

    (9 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (10 People)
  •  好中球細胞外小胞の抗炎症作用の解析~敗血症治療の新規モダリティー開発を目指してPrincipal Investigator

    • Principal Investigator
      熊谷 由美
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Juntendo University
  •  Regulation of the pathological condition of sepsis by focusing the senolytic activity of host defense peptide LL-37

    • Principal Investigator
      長岡 功
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Juntendo University
  •  敗血症治療への応用を目指した好中球細胞外小胞による敗血症病態改善メカニズムの解析Principal Investigator

    • Principal Investigator
      熊谷 由美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Juntendo University
  •  Host defense peptide LL-37 modulates the pathogenesis of sepsis by inducing the release of exosomes

    • Principal Investigator
      長岡 功
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Juntendo University
  •  Towards therapeutic application of neutrophil-secreted extracellular vesicles in sepsisPrincipal Investigator

    • Principal Investigator
      Kumagai Yumi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Juntendo University
  •  人畜共通伝染病を起こすレンサ球菌の髄膜炎発症に関わるシグナル伝達機構の解明Principal Investigator

    • Principal Investigator
      熊谷 由美
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Osaka University
  •  P.gingivalisの産生する赤血球溶血素の遺伝学的及び生化学的解析Principal Investigator

    • Principal Investigator
      熊谷 由美
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The Nippon Dental University
  •  Participation of DPPIV produced by P.gingivalis in periodontal disease.

    • Principal Investigator
      YOSHIKAWA Masanosuke
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The Nippon Dental University
  •  Molecular Genetics on Proteases of Porphyromonas

    • Principal Investigator
      YOSHIKAWA Masanosuke
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Nippon Dental University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

  • [Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019

    • Author(s)
      熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡 功
    • Total Pages
      82
    • Publisher
      医学図書出版株式会社
    • ISBN
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Journal Article] Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches2024

    • Author(s)
      Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrugger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty,.. .Kumagai, Y.,... Witwer, K. W
    • Journal Title

      Journal of Extracellular Vesicles

      Volume: 13 Issue: 2

    • DOI

      10.1002/jev2.12404

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07056, KAKENHI-PROJECT-19K07562, KAKENHI-PROJECT-21K08670, KAKENHI-PROJECT-23K21269, KAKENHI-PROJECT-21H02706
  • [Journal Article] Modified drug-susceptibility testing and screening culture agar for colistin-susceptible Enterobacteriaceae isolates harboring a mobilized colistin resistance gene mcr-9.2022

    • Author(s)
      Kananizadeh P, Tada T, Oshiro S, Hishinuma T, Tohya M, Uehara Y, Kumagai Y, Nagaoka I, Nishi K, Hashimoto M, Watanabe S, Kirikae T
    • Journal Title

      J Clin Microbiol

      Volume: 60 Issue: 12

    • DOI

      10.1128/jcm.01399-22

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07486, KAKENHI-PROJECT-19KK0203
  • [Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils2020

    • Author(s)
      Kumagai Y, Murakami T, Kuwahara-Arai, Iba T, Reich J, Nagaoka I
    • Journal Title

      Innate Immun

      Volume: 26 Issue: 7 Pages: 565-579

    • DOI

      10.1177/1753425920936754

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-19K07562, KAKENHI-PROJECT-20K07486
  • [Journal Article] Therapeutic Action of Antimicrobial Cathelicidin Peptide LL-37 on a Murine Sepsis Model2020

    • Author(s)
      Nagaoka I, Hu Z, Hosoda H, Kumagai Y
    • Journal Title

      Juntendo Medical Journal

      Volume: 66 Issue: 4 Pages: 297-311

    • DOI

      10.14789/jmj.2020.66.JMJ20-R08

    • NAID

      130007893567

    • ISSN
      2187-9737, 2188-2126
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-20K07486
  • [Journal Article] Therapeutic action of antimicrobial cathelicidin peptide LL-37 on a murine sepsis model2020

    • Author(s)
      Nagaoka I, Hu Z, Hosoda H, Kumagai Y
    • Journal Title

      Juntendo Medical Journal

      Volume: 66 Pages: 297-311

    • NAID

      130007893567

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 生体防御ペプチドLL-37は、抗菌活性を有する細胞外小胞の放出を促進することで マウス敗血症の病態改善に関与する2023

    • Author(s)
      熊谷由美、角田宗一郎、洲崎悦生、長岡功
    • Organizer
      日本エンドトキシン・自然免疫研究会
    • Data Source
      KAKENHI-PROJECT-22K07056
  • [Presentation] 生体防御ペプチドLL-37は、抗菌活性を有する細胞外小胞の放出を促進することで マウス敗血症の病態改善に関与する2023

    • Author(s)
      熊谷 由美、角田 宗一郎、 洲崎 悦生、長岡 功
    • Organizer
      日本エンドトキシン・自然免疫研究会
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 抗菌活性を持つ好中球由来エクトソームはマウス敗血症病態を改善する.2022

    • Author(s)
      熊谷由美, 呉林なごみ, 長岡 功, 洲崎悦生
    • Organizer
      第95回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] マウス敗血症の病態改善に関与する好中球由来細胞外小胞.2021

    • Author(s)
      熊谷由美, 宮原克, 長岡功、洲崎悦生.
    • Organizer
      第8回日本細胞外小胞学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] LL-37 ameliorates mouse sepsis by inducing the secretion of antibacterial extracellular vesicles2021

    • Author(s)
      Kumagai Y, Kakuta S, Kuwahara K, Susaki E, Nagaoka I
    • Organizer
      10th Annual Meeting ISEV (International Society of Extracellular Vesicles) 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] LL-37 ameliorates mouse sepsis by inducing the section of antimicrobial microvesicles from neutrophils.2021

    • Author(s)
      Kumagai Y, Kakuta S, Kuwahara K, Susaki E, and Nagaoka I
    • Organizer
      The International Society of Extracellular Vesicles 2021
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 生体防御ペプチドLL-37は、抗菌活性を有する細胞外小胞の放出を介してマウス敗血症の病態改善をする2021

    • Author(s)
      熊谷由美, 角田宗一郎, 桒原京子, 長岡 功
    • Organizer
      第94回日本細菌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] Neutrophil-derived ectosomes with antibacterial potential ameliorate mouse sepsis2021

    • Author(s)
      Kumagai Y, Kurebayashi N, Nagaoka I, Susaki E
    • Organizer
      The 95th annual meeting of the Japanese Society of Bacteriology.
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] Antimicrobial peptide LL-37 induces neutrophil-derived extracellular vesicles with antibacterial potential and protects murine sepsis2020

    • Author(s)
      Kumagai Y, Murakami T, Kuwahara K, Nagaoka I
    • Organizer
      ISEV (International Society of Extracellular Vesicles) 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] 生体防御ペプチドLL-37 の敗血症モデルに対する保護効果2020

    • Author(s)
      長岡 功, 熊谷由美, 細田浩司, 村上泰介, 鈴木 香
    • Organizer
      第93回日本細菌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] 生体防御ペプチドLL-37による抗菌活性を有する細胞外小胞の放出を介したマウス敗血症の病態改善2020

    • Author(s)
      熊谷由美 射場敏明 長岡功
    • Organizer
      第7回 日本細胞外小胞学会
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 生体防御ペプチドLL-37による抗菌活性を有する細胞外小胞の放出を介したマウス敗血症の病態改善2020

    • Author(s)
      熊谷由美, 射場敏明, 長岡 功
    • Organizer
      第7回日本細胞外小胞学会
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] 生体防御ペプチドLL-37は、抗菌活性を有する細胞外小胞の放出を介してマウス敗血症の病態改善をする2020

    • Author(s)
      熊谷由美 角田宗一郎 桒原京子 長岡功
    • Organizer
      第94回 日本細菌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] Antimicrobial peptide LL-37 induces antibacterial ectosomes from neutrophils2020

    • Author(s)
      熊谷由美, 村上泰介, 桑原京子, 長岡 功
    • Organizer
      第93回日本細菌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07486
  • [Presentation] Antimicrobial peptide LL-37 induces neutrophil-derived extracellular vesicles with antibacterial potential and protects murine sepsis2020

    • Author(s)
      Kumagai Y, Murakami T, Kuwahara-Arai K, Nagaoka I
    • Organizer
      International Society of Extracellular Vesicles 2020(国際細胞外小胞学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] Antimicrobial peptide LL-37 induces antibacterial ectosomes from neutrophils2019

    • Author(s)
      熊谷由美, 村上泰介, 桑原京子, 長岡 功
    • Organizer
      第93回日本細菌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 抗菌ペプチドLL-37は好中球からの細胞外小胞の放出を介してマウス敗血症を改善する2019

    • Author(s)
      熊谷由美, 村上泰介, 長岡 功
    • Organizer
      第66回トキシンシンポジウム
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 生体防御ペプチドLL-37 の敗血症モデルに対する保護効果2019

    • Author(s)
      長岡 功, 熊谷由美, 細田浩司, 村上泰介, 鈴木 香
    • Organizer
      第93回日本細菌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07562
  • [Presentation] 抗菌ペプチドLL-37による好中球細胞外(エクトソーム)の放出を介したマウス敗血症の病態改善2019

    • Author(s)
      熊谷由美, 村上泰介, 桒原 京子, 長岡 功
    • Organizer
      第6回日本細胞外小胞学会
    • Data Source
      KAKENHI-PROJECT-19K07562
  • 1.  長岡 功 (60164399)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 23 results
  • 2.  射場 敏明 (40193635)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 3.  YOSHIKAWA Masanosuke (80012714)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKAHASHI Yukihiro (00281436)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KONISHI Kiyoshi (20178289)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KURAMOCHI Toshiaki (80277590)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SAIKI Keitaro (30297973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YAJIMA Ayako (00287773)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  鈴木 香 (90631929)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KUWAHARA Kyoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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