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Kawahito Koji  川人 宏次

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KAWAHITO KOJI  川人 宏次

川人 宏次  カワヒト コウジ

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Researcher Number 90281740
Other IDs
Affiliation (Current) 2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2014 – 2023: 自治医科大学, 医学部, 教授
1998 – 1999: 自治医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Cardiovascular surgery / Basic Section 55030:Cardiovascular surgery-related / Thoracic surgery
Except Principal Investigator
Cardiovascular surgery / Basic Section 55030:Cardiovascular surgery-related / Cardiovascular medicine
Keywords
Principal Investigator
大動脈二尖弁 / 数値流体力学 / 大動脈瘤 / 先天性大動脈二尖弁 / MMP / 血管平滑筋細胞 / 血管内皮細胞 / 壁せん断応力 / 共培養モデル / 壁剪断応力 … More / 内皮細動-平滑筋細胞共培養モデル / 衝突噴流 / 遺伝子 / 胸部大動脈拡大 / 数値流体力学計算 / 細胞間接着分子 / 遺伝子発現解析 / 剪断応力 / 胸部大動脈瘤 / シェアストレス / 遺伝子解析 / 先天性大動脈2尖弁 / 網羅的遺伝子解析 / 数値流体計算 / 上行大動脈瘤 / 大動脈弁二尖弁 / PCPS / リンパ球 / 心臓手術 / アポトーシス / 体外循環 … More
Except Principal Investigator
せん断応力 / 慢性解離性大動脈瘤 / 血管平滑筋細胞 / 壁せん断応力 / 数値流体力学研究 / 慢性大動脈解離 / 大動脈炎症候群 / 大血管外科学 / 血管炎マウスモデル / IL-33 / 血管炎モデルマウス / 大動脈炎 / IL-1受容体アンタゴニスト欠損マウス / IL-25 / 大動脈炎モデルマウス / 大型血管炎 / 数値流体力学 / 大動脈二尖弁化 / 胸部大動脈拡大 / ミニブタ / 二尖弁化 / 大動脈拡大 / 大動脈二尖弁 / 夜間高血圧 / 基底血圧 / IT家庭血圧モニタリング / トリガー血圧計 / スリープサージ / 夜間血圧 Less
  • Research Projects

    (8 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (23 People)
  •  せん断応力負荷による血管平滑筋細胞の生体反応と大動脈解離偽腔拡大の関連性の検討

    • Principal Investigator
      相澤 啓
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Jichi Medical University
  •  Influence of shear stress on human aortic endothelial cell/smooth muscle cell interaction in bicuspid aortic valve aortopathyPrincipal Investigator

    • Principal Investigator
      Kawahito Koji
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Jichi Medical University
  •  Characterization of wall shear stress sensitive genes in bicuspid aortic valve aortopathyPrincipal Investigator

    • Principal Investigator
      Koji Kawahito
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Jichi Medical University
  •  IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice

    • Principal Investigator
      ITOH Satoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Jichi Medical University
  •  Bicuspidalization of the native tricuspid aortic valve using a miniature pig

    • Principal Investigator
      KIMURA Naoyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Jichi Medical University
  •  Research and development of IT multi-trigger nocturnal home blood pressure monitoring system and clinical study

    • Principal Investigator
      Kario Kazuomi
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Jichi Medical University
  •  Patient-specific assessment of hemodynamics by computational fluid dynamics and gene expression profiling in patients with bicuspid aortopathy.Principal Investigator

    • Principal Investigator
      KAWAHITO KOJI
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Jichi Medical University
  •  体外循環時のリンパ球減少におけるアポトーシスの関与Principal Investigator

    • Principal Investigator
      川人 宏次
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Thoracic surgery
    • Research Institution
      Jichi Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Appropriate sizing of the frozen elephant trunk: How to predict proximal descending aortic diameter prior to dissection?2024

    • Author(s)
      1.Kitada Y, Okamura H, Yamauchi T, Nishi S, Arakawa M, Kimura N, Kawahito K, Yamaguchi A.
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: - Issue: 2 Pages: 542-551.e3

    • DOI

      10.1016/j.jtcvs.2024.01.030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Journal Article] Impact of residual entry tears in the descending aorta after type-A dissection2024

    • Author(s)
      Koji Kawahito, Naoyuki Kimura, Atsushi Yamaguchi, Kei Aizawa
    • Journal Title

      Annals of Thoracic Surgery

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Journal Article] A Compressed Collagen Construct for Studying Endothelial-Smooth Muscle Cell Interaction under High Shear Stress2022

    • Author(s)
      Yuya Hiroshima, Yuki Oyama, Kaoru Sawasaki, Masanori Nakamura, Naoyuki Kimura, Koji Kawahito, Hiromichi Fujie, Naoya Sakamoto
    • Journal Title

      Annals of Biomedical Engineering

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Journal Article] Compressed Collagen Construct for Studying Endothelial Smooth Muscle Cell Interaction Under High Shear Stress2022

    • Author(s)
      Hiroshima Y, Oyama Y, Sawasaki K, Nakamura M, Kimura N, Kawahito K, Fujie H
    • Journal Title

      Ann Biomed Eng.

      Volume: - Issue: 8 Pages: 951-963

    • DOI

      10.1007/s10439-022-02972-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10763, KAKENHI-PROJECT-20K09154
  • [Journal Article] Bicuspidalization of the Native Tricuspid Aortic Valve: A Porcine in Vivo Model of Bicuspid Aortopathy2022

    • Author(s)
      Kimura N, Itagaki R, Nakamura M, Tofrizal A, Yatabe M, Yoshizaki T, Kokubo R, Hishikawa S, Kunita S, Adachi H, Misawa Y, Yashiro T, Kawahito K.
    • Journal Title

      Ann Vasc Dis

      Volume: 15 Issue: 1 Pages: 37-44

    • DOI

      10.3400/avd.oa.21-00116

    • ISSN
      1881-641X, 1881-6428
    • Year and Date
      2022-03-25
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Journal Article] Influence of residual primary entry following the tear-oriented strategy for acute type A aortic dissection2021

    • Author(s)
      Kawahito K, Aizawa K, Kimura N, Yamaguchi A, Adachi H
    • Journal Title

      Euro J Cardiothorac Surg

      Volume: - Issue: 5 Pages: 1077-84

    • DOI

      10.1093/ejcts/ezab456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Journal Article] Patient-specific assessment of hemodynamics by computational fluid dynamics in patients with bicuspid aortopathy.2017

    • Author(s)
      Kimura N, Nakamura M, Komiya K, Nishi S, Yamaguchi A, Tanaka O, Misawa Y, Adachi H, Kawahito K.
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 153 Issue: 4 Pages: S52-S62.e3

    • DOI

      10.1016/j.jtcvs.2016.12.033

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462117
  • [Journal Article] Blood flow competition after aortic valve bypass: an evaluation using computational fluid dynamics2017

    • Author(s)
      Kawahito Koji、Kimura Naoyuki、Komiya Kenji、Nakamura Masanori、Misawa Yoshio
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: 24 Pages: ivw428-ivw428

    • DOI

      10.1093/icvts/ivw428

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462117
  • [Presentation] 壁せん断応力に対する血管内皮細胞内アクチンフィラメント構造の変化.2024

    • Author(s)
      山﨑瑠海, 髙橋幸慈, 沢崎薫, 中村匡徳, 木村直行, 川人宏次, 坂元尚哉.
    • Organizer
      第36回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 壁せん断応力下の血管平滑筋細胞の形態応答における内皮細胞間との相互作用2024

    • Author(s)
      沢崎薫、中村匡徳、木村直行、川人宏次、山﨑雅史、藤江裕道、坂元尚哉.
    • Organizer
      第63回日本生体医工学会大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] Malperfusionを伴った急性大動脈解離の外科治療 up-to date. 術後LOSからの回復, Central ECMO with LV ventの有用性.2024

    • Author(s)
      川人宏次
    • Organizer
      第88回日本循環器学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 内皮細胞間との相互作用による血管平滑筋細胞への力学環境情報伝達.2024

    • Author(s)
      沢崎薫、中村匡徳、木村直行、川人宏次、山﨑雅史、藤江裕道、坂元尚哉
    • Organizer
      日本機械学会2024年度年次大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] Interaction with endothelial cells induces vascular smooth muscle cell orientation under wall shear stress condition.2024

    • Author(s)
      Sawasaki K, Nakamura M, Kimura N, Kawahito K, Yamazaki M, Fujie H, Sakamoto N.
    • Organizer
      Biomechanics, Bioengineering and Biotransport Conference.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 術前シュミレーターZed Stentgraftを用いた大動脈解離のステントグラフトの留置形態予測についての検討.2023

    • Author(s)
      荒川衛、北田悠一郎、秋吉慧、岡村誉、相澤啓、川人宏次.
    • Organizer
      第51回日本血管外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] Vascular Smooth Muscle Cell Orientation Induced by Cocultured Endothelial Cells Subjected to Wall Shear Stress2023

    • Author(s)
      Kaoru Sawasaki, Masanori Nakamura, Naoyuki Kimura, Koji Kawahito, Hiromichi Fujie, Naoya Sakamoto.
    • Organizer
      2023 BMES Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 壁せん断応力に対する内皮細胞を介した血管平滑筋細胞の形態変化.2023

    • Author(s)
      沢崎薫、中村匡徳、木村直行、川人宏次、藤江裕道、坂元尚哉.壁せん断応力に対する内皮細胞を介した血管平滑筋細胞の形態変化.
    • Organizer
      日本機械学会2023年度年次大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 血管内皮細胞によるNO産生と衝突噴流環境との関係.2023

    • Author(s)
      沢崎薫、山﨑瑠海、髙橋幸慈、中村匡徳、木村直行、川人宏次、坂元尚哉.
    • Organizer
      第46回バイオレオロジー学会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 壁せん断応力環境下における内皮細胞と共培養した血管平滑筋細胞の形態変化.2023

    • Author(s)
      沢崎薫、中村匡徳、木村直行、川人宏次、藤江裕道、坂元尚哉.
    • Organizer
      第62回日本生体医工学会大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] Phenotypic States of Smooth Muscle Cells in a Coculture Model under Higher Wall Shear Stress Condition2022

    • Author(s)
      Sawasaki K, Nakamura M, Kimura N, Kawahito K, Fujie H, Sakamoto N
    • Organizer
      2022 BMES Annual Meeting
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] FET時代の解離の治療戦略 - 年齢に基づいたIII型逆行性解離に対する遠位側拡大手術の適応2022

    • Author(s)
      川人宏次、相澤啓、木村直行、山口敦司、安達秀雄
    • Organizer
      第52回日本心臓血管外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 高壁せん断応力を負荷した共培養血管モデルにおける平滑筋細胞の表現型2022

    • Author(s)
      沢崎薫、中村匡徳、木村直行、川人宏次、藤江裕道、坂元尚哉
    • Organizer
      日本機械学会 2022年度年次大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] Simulated endovascular intervention for the 3D model of type A aortic dissection with the pulsatile mock circuit as an experimental model2022

    • Author(s)
      Arakawa M, Sumikura H, Okamura H, Aizawa K, Homma A, Kawahito K.
    • Organizer
      European Association for cardiothoracic surgery annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 定常流型補助人工心臓の長期管理における自己心拍同期回転制御システムの可能性2022

    • Author(s)
      荒川衛、北田悠一郎、岡村誉、川人宏次
    • Organizer
      第60回日本人工臓器学会大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 衝突噴流に伴う力学刺激の組み合わせ環境が血管内皮細胞に及ぼす影響2022

    • Author(s)
      髙橋幸慈、沢崎薫、中村匡徳、木村直行、川人宏次、坂元尚哉
    • Organizer
      第32回バイオフロンティア講演会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] Study on Effect of Extreme Shear Condition on Endothelial Cell and Smooth muscle Cell Functions using Compressed Collagen Construct2022

    • Author(s)
      Sakamoto N, Oyama Y, Sawasaki K, Hiroshima Y, Nakamura M, Kimura N, Kawahito K, Fujie H.
    • Organizer
      9th World Congress of Biomechanics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 衝突噴流に伴う力学刺激の組み合わせ環境が血管内皮細胞に及ぼす影響2022

    • Author(s)
      髙橋幸慈、沢崎薫、中村匡徳、木村直行、川人宏次、坂元尚哉
    • Organizer
      第32回バイオフロンティア講演会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] Study on Effect of Extreme Shear Condition on Endothelial Cell and Smooth muscle Cell Functions using Compressed Collagen Construct.2022

    • Author(s)
      1.Sakamoto N, Oyama Y, Sawasaki K, Hiroshima Y, Nakamura M, Kimura N, Kawahito K, Fujie H
    • Organizer
      9th World Congress of Biomechanics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 壁せん断応力-法線方向動圧組み合わせ環境が血管内皮細胞に及ぼす影響.2022

    • Author(s)
      髙橋幸慈、沢崎薫、中村匡徳、木村直行、川人宏次、坂元尚哉.
    • Organizer
      第45回日本バイオレオロジー学会年会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 高壁せん断応力が内皮細胞と共培養した血管平滑筋細胞の表現型へ及ぼす影響2022

    • Author(s)
      沢崎薫、中村匡徳、木村直行、川人宏次、藤江裕道、坂元尚哉
    • Organizer
      第61回日本生体医工学会大会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 弁形態分析に基づく大動脈二尖弁狭窄症例の上行大動脈拡大と治療成績に関する検討2021

    • Author(s)
      木村直行, 堀大治郎, 草処翔, 清水寿和,   野村陽平, 白石学, 川人宏次, 山口敦司
    • Organizer
      第49回日本血管外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 大動脈二尖弁性狭窄と大動脈三尖弁性狭窄の治療成績とaortic stiffnessに関する検討2021

    • Author(s)
      木村直行, 堀大治郎, 草処翔, 清水寿和, 白石学,川人宏次, 山口敦司
    • Organizer
      第51回日本心臓血管外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 大動脈二尖弁性狭窄と大動脈三尖弁性狭窄の治療成績とaortic stiffnessに関する検討2021

    • Author(s)
      木村直行, 堀大治郎, 草処翔, 清水寿和, 白石学,川人宏次, 山口敦司
    • Organizer
      第51回日本心臓血管外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 弁形態分析に基づく大動脈二尖弁狭窄症例の上行大動脈拡大と治療成績に関する検討2021

    • Author(s)
      木村直行, 堀大治郎, 草処翔, 清水寿和,   野村陽平, 白石学, 川人宏次, 山口敦司
    • Organizer
      第49回日本血管外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 衝突噴流環境が血管内皮細胞へ及ぼす影響2020

    • Author(s)
      沢崎薫 ,堀江悠太,中村匡徳,木村直行,川人宏次,坂元尚哉
    • Organizer
      生体医工学会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 内皮-平滑筋細胞共培養モデルのMMP産生に対する高壁せん断応力環境の影響2020

    • Author(s)
      坂元尚哉,大山侑樹,中村匡徳,木村直行,川人宏次,山崎雅史,藤江裕道
    • Organizer
      第59回日本生体医工学会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 衝突噴流環境が血管内皮細胞へ及ぼす影響2020

    • Author(s)
      沢崎薫,堀江悠太,中村匡徳,木村直行, 川人宏次,坂元尚哉
    • Organizer
      第59回日本生体医工学会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 衝突噴流が血管内皮細胞間接着に及ぼす影響2020

    • Author(s)
      沢崎 薫,堀江 悠太,中村 匡徳,木村 直行,川人 宏次,坂元 尚哉
    • Organizer
      日本機械学会第33回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 衝突噴流が血管内皮細胞間接着に及ぼす影響2020

    • Author(s)
      沢崎 薫,堀江 悠太,中村 匡徳,木村 直行,川人 宏次,坂元 尚哉
    • Organizer
      日本機械学会第33回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 内皮-平滑筋細胞共培養モデルのMMP産生に対する高壁せん断応力環境の影響2020

    • Author(s)
      坂元尚哉,大山侑樹,中村匡徳,木村直行,川人宏次,山崎雅史,藤江裕道
    • Organizer
      第59回日本生体医工学会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 衝突噴流環境が血管内皮細胞へ及ぼす影響2020

    • Author(s)
      沢崎薫,堀江悠太,中村匡徳,木村直行, 川人宏次,坂元尚哉
    • Organizer
      第59回日本生体医工学会
    • Data Source
      KAKENHI-PROJECT-20K09154
  • [Presentation] 圧縮コラーゲン組織を用いた共培養モデルに対する 高壁せん断応力の影響2019

    • Author(s)
      大山侑樹, 中村匡徳, 木村直行, 川人宏次, 山崎雅史, 藤江裕道, 坂元尚哉
    • Organizer
      日本機械学会 第 32 回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] Utility of computational fluid dynamics for thoracic aortic pathology in the era of precision medicine2019

    • Author(s)
      NAOYUKI KIMURA, KOKI KAWAHITO, DAJIRO HORI, KOICHI YURI, ATSUSHI YAMAGUCHI, YUUKI OHYAMA, NAOYA SAKAMOTO, MASANORI NAKAMURA
    • Organizer
      第83回 日本循環器病学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] 血管内皮細胞の遊走および剥離に対する衝突流れの場の影響2018

    • Author(s)
      堀江悠太, 大山侑樹, 中村匡徳, 木村直行, 川人宏次, 坂元尚哉
    • Organizer
      日本機械学会 第31回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-17K10763
  • [Presentation] Patient-specific evaluation of hemodynamics in bicuspid aortopathy by means of magnetic resonance imaging based computational fluid dynamics simulation.2016

    • Author(s)
      5.Kimura N, Kawahito K, Komiya K, Numata N, Yamaguchi A, Misawa Y, Nakamura M, Adachi H.
    • Organizer
      AATS Aortic Symposium 2016
    • Place of Presentation
      New York
    • Year and Date
      2016-05-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462117
  • 1.  KIMURA Naoyuki (20382898)
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  • 18.  小古山 由佳子 (80742030)
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  • 19.  江口 和男 (80364503)
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    # of Collaborated Products: 0 results
  • 20.  三沢 吉雄 (90209742)
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  • 21.  市田 勝 (30306146)
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  • 22.  池本 智一 (10458284)
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