HIGAKI Katumi 檜垣克美

… Alternative Names

桧垣克美ヒガキカツミ

HIGAKI Katsumi 檜垣克美

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Researcher Number	90294321
Other IDs
External Links
Affiliation (Current)	2025: 鳥取大学, 研究推進機構, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 鳥取大学, 研究推進機構, 准教授 2007 – 2017: Tottori University, 生命機能研究支援センター, 准教授 2015: 国立大学法人鳥取大学, 生命機能研究支援センター, 准教授 2005 – 2006: 鳥取大学, 生命機能研究支援センター, 助教授 2004: 国立大学法人鳥取大学, 生命機能研究支援センター, 助教授 2001: 鳥取大, 医学部, 助手 1997 – 1999: Tottori University, Department of Nerobiology, Lecturer, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / General medical chemistry / Biological Sciences
Keywords	Principal Investigator 治療法開発 / ライソゾーム病 / シャペロン / ライソゾーム / 脳疾患 / シグナル伝達 / 神経変性疾患 / 中枢神経障害 / 低分子化合物 / 蛋白質分解 … More / 脂質代謝異常 / 小児神経疾患 / 脂質 / コレステロール / 酵素補充療法 / 蛋白質構造異常 / 変異酵素 / 低分子物質 / アロステリック / 治療法研究 / 酵素蛋白質 / 脳病態 / ムコ多糖症 / 神経変性 / 酵素活性 / 先天代謝異常症 / 脂質蓄積 / 病態解析 / 脂質代謝 / 転写因子 / リン脂質 / モデルマウス / 小胞体 / ケミカルシャペロン / 脂質代謝異常症 / ファブリー病 / 細胞内輸送 / 小児神経 / シグナル伝逹 / 脳神経疾患 / 疾患モデルマウス / マイクロアレイ / 脳神経疾 / 神経栄養因子 / 病態解明 / 神経遺伝病 / アルツハイマー病 / 細胞内小胞輸送 / 酵母 / 銅代謝 / メンケス病 … More Except Principal Investigator シャペロン / 治療法開発 / 先天代謝異常症 / ライソゾーム病 / 糖鎖 / オートファジー / 糖蛋白 / dehydrodolichol reductase / asiolotransferrin / disialotransferrion / carbohydrate-deficient glycoprotein syndrome / 知的障害 / 遺伝病 / 中枢神経障害 / ユビキチン / 神経変性疾患 / シグナル伝達 / 小児神経学 / 自閉症 / fukutin / 福山型筋ジストロフィー / 変異酵素 / ライソゾーム酵素 / 構造異常 / 変異蛋白質 / シャペロン療法 / 自己不活型 / ゴーシェ病 / ファブリー病 / asialotransferrin / disialotransferrin / dolichol / b-hexosaminidase / lysosome / transferrin / sugar chain / carbohydrate-deficient glycoprotein (CDG) / リソソーム酸素 / Carbohydrate-deficient glycoprotein / 先天性N-結合型糖鎖欠乏症候群 / 小脳失調 / ドリコール脂質中間1本 / 小脳** / ドリコール脂質中間体 / CDG症候群 / Carbohydrate-deficient / ドリコール / 小胞体 / 遺伝子変異 / ヒスチジンリピート / HOX遺伝子 / 蛋白質構造 / 脂質代謝異常症 / 脳変成疾患 / 蛋白質立体構造 / アロステリック効果 / シャペロン化合物 / 治療 / 脳疾患 / アロステリックシャペロン / 脂質代謝異常 / エンドサイトーシス / 小児神経変成疾患 / ミトコンドリア / 中枢神経疾患 / ルシフェラーゼ / インシリコ解析 / 低分子化合物 / トランスポート / NPC1-L1 / Rab / コレステロール / ニーマンピック / 糖質 / 病態解明 / 細胞膜 / ライソゾーム / 神経科学 / 脳神経疾患 / 神経変性 / 脂質 / アミノ酸リピート / 神経分化 / 遺伝子 / アミノ酸リビート / DNAチップ / ニューロトランスミッター / ゲノムインプリンティング / 関連遺伝子 Less

ライソゾーム病に対するシャペロン併用療法による新規治療法の開発Principal Investigator
- Principal Investigator
  
  檜垣克美
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tottori University
Development of novel allosteric chaperone therapy for lysosomal storage diseasesPrincipal Investigator
- Principal Investigator
  
  Higaki Katsumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tottori University
Research and development of therapeutic methods for Fukuyama congenital muscular dystrophy focusing on central nervous system dysfunction
- Principal Investigator
  
  Okazaki Tetsuya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tottori University
Identification of novel chaperones for neurodegerative mucopolysaccharidosesPrincipal Investigator
- Principal Investigator
  
  HIGAKI Katsumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Development of new self-inactivating chaperon without side effects
- Principal Investigator
  
  Nanba Eiji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
TFEB mediated therapy for lysosomal storage diseasesPrincipal Investigator
- Principal Investigator
  
  HIGAKI Katsumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Devlopment of a novel allosteric chaperone therapy for genetic diseases.
- Principal Investigator
  
  NANBA EIJI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
The world's first establishment of disease concept and mouse model creation about histidine repeat disease
- Principal Investigator
  
  NANBA EIJI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Molecular analysis of chemical chaperone effect on lysosomal storage diseasesPrincipal Investigator
- Principal Investigator
  
  HIGAKI Katsumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Development of novel therapeutic strategies for neurodegenerative lysosomal storage diseases by ameliorating autophagic degradation and brain-specific peptides
- Principal Investigator
  
  NANBA Eiji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
ケミカルシャペロン療法のための革新的スクリーニング法の開発
- Principal Investigator
  
  難波栄二
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Cholesterol-dependent regulation of intracellular localization of NPC1-L1
- Principal Investigator
  
  NINOMIYA Haruaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tottori University
Microarray analysis and development of a novel molecular targeted therapy for neurodegenerative lysosomal storage diseases.Principal Investigator
- Principal Investigator
  
  HIGAKI Katsumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
The mechanism of the central nervous system degeneration on lysosomal storage diseases : abnormality of cell membrane and autophagy
- Principal Investigator
  
  NANBA Eiji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
神経栄養因子を用いたリソソーム蓄積症神経変性治療法の開発Principal Investigator
- Principal Investigator
  
  檜垣克美 (桧垣克美)
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
アミノ酸リピート変異に注目した自閉症などの小児神経疾患発症メカニズムの解明
- Principal Investigator
  
  難波栄二
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
遺伝研究コンソーシアムによる自閉症関連遺伝子の解明
- Principal Investigator
  
  NANBA Eiji
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
銅を標的としたニーマン・ピック病C型の治療法の開発Principal Investigator
- Principal Investigator
  
  桧垣克美 (檜垣克美)
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
ニーマン・ピック病C型原因遺伝子(NPC_2)の単離と機能解析Principal Investigator
- Principal Investigator
  
  桧垣克美
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
PATHOPHYSIOLOGY OF CARBOHYDRATE-DEFICIET GLYCOPROTEIN SYNDROME
- Principal Investigator
  
  OHNO Kousaku
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  TOTTORI UNIVERSITY
Research on the basic defect of carbohydrate-deficient glycoprotein syndrome
- Principal Investigator
  
  OHNO Kousaku
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University

[Book] Mucopolysaccharidoses Updates2018
- Author(s)
  Higaki K, Ninomiya H
- Total Pages
  811
- Publisher
  NOCA Science Publishers
- ISBN
  9781536139860
- Data Source
  KAKENHI-PROJECT-17K10051
[Book] GM1-ガングリオシドーシス（先天代謝異常症候群第2版)2012
- Author(s)
  檜垣克美
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23591498
[Book] GM1-ガングリオシドーシス.先天代謝異常症候群第2版2012
- Author(s)
  檜垣克美、足立香織、難波栄二
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-22390207
[Book] GM1-ガングリオシドーシス（先天代謝異常症候群第2版2012
- Author(s)
  檜垣克美
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-22390207
[Book] Brain Medical(メディカルレビュー社)2012
- Author(s)
  難波栄二、檜垣克美
- Publisher
  ガングリオシドーシス
- Data Source
  KAKENHI-PROJECT-22390207
[Book] 血液フロンティア(医薬ジャーナル社)2011
- Author(s)
  難波栄二、檜垣克美
- Publisher
  イソゾーム病の病因
- Data Source
  KAKENHI-PROJECT-22390207
[Book] 生体の科学(ガングリオシド蓄積症とシグナル伝達)(60巻3号)2009
- Author(s)
  檜垣克美、難波栄二
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-20790728
[Book] 生体の科学特集脳と糖脂質「ガングリオシド蓄積症とシグナル伝達」2009
- Author(s)
  檜垣克美、灘波栄二
- Publisher
  (財)金原一郎記念医学医療振興財団/医学書院
- Data Source
  KAKENHI-PROJECT-20790728
[Book] BallabioA (eds) : The Online Metabolic anMolecular Bases of Inherited Disease2008
- Author(s)
  Suzuki Y, Nanba E, Matsuda J, Higaki KOshima A
- Publisher
  -Galactosidase deficiency(-galactosidosis) -Galactosidosis and Morquio B disease. Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SF
- Data Source
  KAKENHI-PROJECT-18390299
[Book] アストロサイトのオートファジー生体の科学(59巻6号)2008
- Author(s)
  檜垣克美、難波栄二
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-20790728
[Book] 生体の科学592008
- Author(s)
  檜垣克美, 難波栄二
- Publisher
  アストロサイトのオートファジーとMtor
- Data Source
  KAKENHI-PROJECT-18390299
[Book] 生体の科学, 特集mTORをめぐるシグナルタンパク2008
- Author(s)
  檜垣克美
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-18390299
[Book] 生体の科学,特集mTORをめぐるシグナルタンパク2008
- Author(s)
  檜垣克美
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-20790728
[Book] 小児科診断2006
- Author(s)
  難波栄二, 檜垣克美, Udin Bahrudin
- Publisher
  遺伝子診断の実機
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease.2022
- Author(s)
  Gonzalez-Cuesta M, Herrera-Gonza;lez I, Garcia-Moreno MI, Ashmus RA, Vocadlo DJ, Garcia Fernandez JM, Nanba E, Higaki K, Ortiz Mellet C.
- Journal Title
  
  J Enzyme Inhib Med Chem
  
  Volume: 37 Issue: 1 Pages: 1364-1374
- DOI
  10.1080/14756366.2022.2073444
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07821
[Journal Article] Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann?Pick disease type C without hearing loss2022
- Author(s)
  Yamada Y, Miwa T, Nakashima M, Shirakawa A, Ishii A, Namba N, Kondo Y, Takeo T, Nakagata N, Motoyama K, Higashi T, Arima H, Kurauchi Y, Seki T, Katsuki H, Okada Y, Ichikawa A, Higaki K, Hayashi K, Minami K, Yoshikawa N, Ikeda R, Ishikawa Y, Kajii T, Tachii K, Takeda H, Orita Y, Matsuo M, Irie T, Ishitsuka Y
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 155 Pages: 113698-113698
- DOI
  10.1016/j.biopha.2022.113698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06596, KAKENHI-PROJECT-21K07821, KAKENHI-PROJECT-22K06631, KAKENHI-PROJECT-22K09674, KAKENHI-PROJECT-19K22972, KAKENHI-PROJECT-21K15316, KAKENHI-PROJECT-19K09899, KAKENHI-PROJECT-20K07066, KAKENHI-PROJECT-20K16080
[Journal Article] Pharmacological Chaperones for the Treatment of α-Mannosidosis2019
- Author(s)
  Rocio Risquez-Cuadro, Reimi Matsumoto, Fernando Ortega-Caballero, Eiji Nanba, Katsumi Higaki, Jose-Manuel Garcia-Fernandez, Carmen Ortiz-Mellet
- Journal Title
  
  J Med Chem
  
  Volume: 62 Issue: 12 Pages: 5832-5843
- DOI
  10.1021/acs.jmedchem.9b00153
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10051
[Journal Article] Multivalent Glycoligands With Lectin/Enzyme Dual Specificity: Self-Deliverable Glycosidase Regulators2019
- Author(s)
  Manuel Gonzalez-Cuesta, David Goyard, Eiji Nanba, Katsumi Higaki, Jose M Garcia-Fernandez, Olivier Renaudet, Carmen Ortiz Mellet
- Journal Title
  
  Chem Commun
  
  Volume: 55 Issue: 85 Pages: 12845-12848
- DOI
  10.1039/c9cc06376e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10051
[Journal Article] Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human b-glucocerebrosidase: a picomolar chaperone for Gaucher disease.2018
- Author(s)
  Mena-Barragan T, Garcia-Moreno MI, Sevsek A, Okazaki T, Nanba E, Higaki K, Martin MI, Pieters RJ, García Fernandez JM, Ortiz Mellet C
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 4 Pages: 927-927
- DOI
  10.3390/molecules23040927
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10051
[Journal Article] Inhibitor versus chaperone behaviour of fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.2016
- Author(s)
  Mena-Barragain T
- Journal Title
  
  Eur J Med Chem
  
  Volume: 121 Pages: 880-891
- DOI
  10.1016/j.ejmech.2015.08.038
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461525, KAKENHI-PROJECT-15K15391
[Journal Article] Conformationally –locked N-glycosidase: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.2015
- Author(s)
  Castilla J
- Journal Title
  
  Eur J Med Chem
  
  Volume: 90 Pages: 258-266
- DOI
  10.1016/j.ejmech.2014.11.002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461525, KAKENHI-PROJECT-25293230, KAKENHI-PROJECT-15K15391
[Journal Article] Potent chemical chaperone compounds for GM1-gangliosidosis: N-substituted (+)-conduramine F-4 derivatives.2015
- Author(s)
  Kuno S
- Journal Title
  
  MedChemComm
  
  Volume: 6 Issue: 2 Pages: 206-210
- DOI
  10.1039/c4md00270a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461525, KAKENHI-PROJECT-25293230
[Journal Article] Chaperone therapy for Krabbe disease: potential for late-onset GALC mutations.2015
- Author(s)
  Hossain M
- Journal Title
  
  J Hum Genet
  
  Volume: 60 Issue: 9 Pages: 539-540
- DOI
  10.1038/jhg.2015.61
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461525, KAKENHI-PROJECT-25461543, KAKENHI-PROJECT-25293230
[Journal Article] Highly pH-responsive pharmacological chaperones for mutant glycosidase enhancement.2015
- Author(s)
  Mena-Barragán T
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 54 Issue: 40 Pages: 11696-11700
- DOI
  10.1002/anie.201505147
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461525, KAKENHI-PROJECT-15K15391, KAKENHI-PROJECT-15K21167
[Journal Article] Targeted delivery of pharmacological chaperones for Gaucher disease to marophages by a mannosylated cyclodextrin carrier2014
- Author(s)
  Rodriguez-Lavado J, de la Mata M, Jimenez-Blanco J, Garcia-Moreno MI, Benito JM, Diaz-Quintana A, Sanchez-Alcazar JA, Higaki K, Nanba E, Ohno K, Suzuki Y, Ortiz Mellet C, Garcia Fernandez JM
- Journal Title
  
  Org Biomol Chem
  
  Volume: 12 Pages: 2289-2301
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Targeted delivery of pharmacological chaperones for Gaucher disease to marophages by a mannosylated cyclodextrin carrier.2014
- Author(s)
  Rodriguez-Lavado J
- Journal Title
  
  Org Biomol Chem
  
  Volume: 12 Issue: 14 Pages: 2289-2301
- DOI
  10.1039/c3ob42530d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591498, KAKENHI-PROJECT-25293230, KAKENHI-PROJECT-26461525
[Journal Article] The chaperone activity and toxicity of ambroxol on GD cells and normal mice2013
- Author(s)
  Luan Z, Li L, Higaki K, Nanba E, Suzuki Y, Ohno K
- Journal Title
  
  Brain Dev
  
  Volume: 35 Pages: 317-322
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Two candidate molecules for chemical chaperone therapy for GM1-gangliosidosis2013
- Author(s)
  Higaki K, Ninomiya H, Suzuki Y, Nanba E
- Journal Title
  
  Future Med Chem
  
  Volume: 5 Pages: 1551-1558
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Two candidate molecules for chemical chaperone therapy for GM1-gangliosidosis.2013
- Author(s)
  Higaki K
- Journal Title
  
  Future Med Chem
  
  Volume: 5 Issue: 13 Pages: 1551-1558
- DOI
  10.4155/fmc.13.123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591498, KAKENHI-PROJECT-25293230
[Journal Article] A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM_1 gangliosidosis2013
- Author(s)
  Takai T, Higaki K, Aguilar-Moncayo M, Mena-Barragán T, Hirano Y, Yura K, Yu L, Ninomiya H, García-Moreno I, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, García Fernández JM, Suzuki Y
- Journal Title
  
  Mol Ther
  
  Volume: 21 Pages: 526-532
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 - gangliosidosis2013
- Author(s)
  Takai T, Higaki K, Aguilar-Moncayo M, Mena-Barragan T, Hirano Y, Yura K, Yu L, Ninomiya H, M. Garcia-Moreno I,Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, Jose M. Fernandez G, Suzuki Y
- Journal Title
  
  Mol Ther
  
  Volume: 21 Issue: 3 Pages: 526-532
- DOI
  10.1038/mt.2012.263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] The chaperone activity and toxicity of ambroxol on Gaucher cells and normal mice2013
- Author(s)
  Luan Z,Li LinjingHigaki K, Nanba.E,Suzuki Y, Ohno K
- Journal Title
  
  Brain Dev
  
  Volume: 35 Issue: 4 Pages: 3170322-3170322
- DOI
  10.1016/j.braindev.2012.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Tuning glycosidase inhibition through aglycone interactions: Pharmacological chaperones for Fabry disease and GM1gangliosidosis2012
- Author(s)
  Aguilar-Moncayo M, Takai T, Higaki K, Mena-Barragan T, Hirano Y, Yura K, Li L, Yu Y, Ninomiya H, Garcia-Moreno I, Ishii S, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, Garcia Fernandez JM, Suzuki Y:
- Journal Title
  
  Chem Commun
  
  Volume: 48 Issue: 52 Pages: 6514-6516
- DOI
  10.1039/c2cc32065g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: Identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease2012
- Author(s)
  Castilla J, Risquez R. Cruz D,Higaki K, Nanba E, Ohno K, Suzuki Y, Diaz Y, Ortiz Mellet C, Carcia Fernandez JM, Castillon
- Journal Title
  
  J Med Chem
  
  Volume: 55 Issue: 15 Pages: 6857-6865
- DOI
  10.1021/jm3006178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Therapeutic chaperone effect of N-octyl-4-epi-β-valienamine on murine GM1-gangliosidosis2012
- Author(s)
  Suzuki Y, Ichinomiya S, Kurosawa M, Matsuda D, Ogawa S, Iida M, Kubo T, Tabe M, Itoh M, Higaki K, Nanba E, Ohno K
- Journal Title
  
  Mol Genet Metab
  
  Volume: 106 Pages: 92-98
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Genotype/phenotype of 6 Chinese cases with Niemann-Pick disease type C.2012
- Author(s)
  Xiong H,Higaki K, Wei C, Bao CW, Zhanf YH, Fu N, Qui J, Adachi K, Kumura Y, Ninomiya H, Nanba E,Wu XR
- Journal Title
  
  Gene
  
  Volume: 498 Issue: 2 Pages: 332-335
- DOI
  10.1016/j.gene.2012.01.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207
[Journal Article] Tuning glycosidase inhibition through aglycone interactions : Pharmacological chaperones for Fabry disease and GM1 gangliosidosis2012
- Author(s)
  Aguilar-Moncayo M, Takai T, Higaki K, Mena-Barragán T, Hirano Y, Yura K, Li L, Yu Y, Ninomiya H, García-Moreno MI, Ishii S, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, García Fernández JM, Suzuki Y
- Journal Title
  
  Chem Commun
  
  Volume: 48 Pages: 6514-6516
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Conformationally-Locked N-Glycosides with Selectiveβ-Glycosidase Inhibitory Activity : Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease2012
- Author(s)
  Castella J, Risquez R, Cruz D, Higaki K, Nanba E, Ohno K, Suzuki Y, Diaz Y, Ortiz Mellet C, García Fernández JM, Castellon S
- Journal Title
  
  J Med Chem
  
  Volume: 55 Pages: 6857-6865
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Therapeutic chaperone effect of N-octyl 4-epi-β-valienamine on murine G(M1)-gangliosidosis2012
- Author(s)
  Suzuki Y, Ichinomiya S, Kurosawa M, Matsuda J,Ogawa S, Iida M, Kubo T, Tabe M, Itoh M, Higaki K, Nanba E,Ohno K
- Journal Title
  
  Mol Genet Metab
  
  Volume: 106 Issue: 1 Pages: 92-98
- DOI
  10.1016/j.ymgme.2012.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Lysosomal accumulation of Trk protein in brain of GM1-gangliosidosis mouse and its restoration by chemical chaperone.2011
- Author(s)
  Takamura A., Higaki K., Ninomiya H., Takai T., Matsuda J., Iida M., Ohno K., Suzuki Y., Nanba E.
- Journal Title
  
  J.Neurochem. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency2011
- Author(s)
  HigakKLi L,Bahrudin U, Okuzawa S,Takamura A, Yamamoto K, Adachi K, Paraguison RC, Takai T, Ikehata H, Tominaga L, Hisatome I, Iida M, Ogawa S, Matsuda J, Ninomiya H, Sakakibara Y, Ohno K, Suzuki Y, Nanba E
- Journal Title
  
  Hum Mutat
  
  Volume: 32 Issue: 7 Pages: 843-852
- DOI
  10.1002/humu.21516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Lysosomal storage causes cellular dysfunction in mucolipidosis II skin fibroblasts2011
- Author(s)
  Otomo T, Higaki K, Nanba E, Ozono K, Sakai N
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 35283-35290
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Lysosomal storage causes cellular dysfunction In mucolipidosis II skin fibroblasts2011
- Author(s)
  Otomo T
- Journal Title
  
  J Biol Chem
  
  Volume: 286(40) Issue: 40 Pages: 35283-35290
- DOI
  10.1074/jbc.m111.267930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591319, KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.2011
- Author(s)
  Ting Y., Morikawa K., Kurata Y., Li P., Bahrudin U., Mizuta E., Kato M., Miake J., Yamamoto Y., Yoshida A., Murata M., Inoue T., Nakai A., Shiota G, Higaki K., Nanba E., Ninomiya H., Shirayoshi Y., Hisatome I.
- Journal Title
  
  Br.J.Pharmacol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] An"exacerbate-reverse"strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease2011
- Author(s)
  Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 23842-23851
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Chemical chaperone therapy : chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency.2011
- Author(s)
  Higaki K., Li L., Bahrudin U., Okuzawa S., Takamura A., Yamamoto K., Adachi K., Paraguison R.C., Takai T., Ikehata H., Tominaga L., Hisatome I., Iida M., Ogawa S., Matsuda J., Ninomiya H., Sakakibara Y., Ohno K., Suzuki Y., Nanba E.
- Journal Title
  
  Human Mut. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Chemical chaperone therapy : chaperone effect on mutant enzyme and cellular pathophysiology inβ-galactosidase deficiency2011
- Author(s)
  Higaki K, Li L, Bahrudin U, Okuzawa S, Takamura A, Yamamoto K, Adachi K, Paraguison RC, Takai T, Ikehata H, Tominaga L, Hisatome I, Iida M, Ogawa S, Matsuda J, Ninomiya H, Sakakibara Y, Ohno K, Suzuki Y, Nanba E
- Journal Title
  
  Hum Mutat
  
  Volume: 32 Pages: 843-852
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Lysosomal accumulation of Trk protein in brain of GM1-gangliosidosis mouse and its restoration by chemical chaperone2011
- Author(s)
  Takamura A, Higaki K, Ninomiya H, Takai T, Matsuda J, Iida M, Ohno K, Suzuki Y, Nanba E
- Journal Title
  
  J Neurochem
  
  Volume: 118 Pages: 399-406
- Data Source
  KAKENHI-PROJECT-23591498
[Journal Article] Lysosomal accumulation of Trk protein in brain of GM1-gangliosidosis mouse and its restoration by chemical chaperone.2011
- Author(s)
  Takamura A,Higaki K,Ninomiaya H,Takai T, Matsuda J, Iida M, Ohno K, Suzuki Y, Nanba E
- Journal Title
  
  J Neurochem
  
  Volume: 118 Issue: 3 Pages: 399-406
- DOI
  10.1111/j.1471-4159.2011.07310.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207, KAKENHI-PROJECT-23591498
[Journal Article] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability.2011
- Author(s)
  Li P., Ninomiya H., Kurata Y., Kato M., Miake J., Yamamoto Y., Igawa O., Nakai A., Higaki K., Toyoda F., Wu J., Horie M., Matsuura H., Yoshida A., Shirayoshi Y., Hiraoka M., Hisatome I.
- Journal Title
  
  Cir.Res. 108
  
  Pages: 458-468
- NAID
  130002130408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] A fluorescent sp2-iminosugar with pharmacological chaperone activity for Gaucher disease: Synthesis and intracellular distribution studies2010
- Author(s)
  Luan Z,Higaki K, Aquilar-Moncayo M, Li L, Ninomiya H, Nanba E Ohno K, Garcia-Moreno MI, Ortiz Mellet C, GarciaFernandez JM, Suzuki Y.
- Journal Title
  
  ChemBioChem
  
  Volume: 11 Issue: 17 Pages: 2453-2463
- DOI
  10.1002/cbic.201000323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207
[Journal Article] A fluorescent sp2-iminosugar with pharmacological chaperone activity for Gaucher disease : Synthesis and intracellular distribution studies.2010
- Author(s)
  Luan Z, Higaki K, Aquilar-Moncayo M, Li L, Ninomiya H, Nanba E, Ohno K, Garcia-Moreno MI, Ortiz Mellet C, Garcia Fernandez JM, Suzuki Y1 :
- Journal Title
  
  ChemBioChem 11
  
  Pages: 2453-2463
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] A fluorescent sp^2-iminosugar with pharmacological chaperone activity for Gaucher disease : synthesis and intracellular distribution studies.2010
- Author(s)
  Luan Z., Higaki K., Aguilar-Moncayo M., Li L., Ninomiya H., Nanba E., Ohno K., Garcia-Moreno M.I., Ortiz M.C., Garcia Fernandez J.M., Suzuki Y.
- Journal Title
  
  Chembiochem. 11
  
  Pages: 2453-2464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Chemical chaperone therapy : Luciferase assay for screening of β-galactosidase mutations.2010
- Author(s)
  Li L, Higaki K, Ninomiya H, Luan Z, Iida M, Ogawa S, Suzuki Y, Ohno K, Nanba E.
- Journal Title
  
  Mol Genet Metab 101
  
  Pages: 354-369
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] Chemical chaperone therapy: luciferase assay for screening of β-galactosidase mutations2010
- Author(s)
  Li L,Higaki K, Ninomiya H, Luan Z, Iida M, Ogawa S, Suzuki Y, Ohno K, Nanba E.
- Journal Title
  
  Mol Genet Metab
  
  Volume: 101 Issue: 4 Pages: 354-369
- DOI
  10.1016/j.ymgme.2010.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390207
[Journal Article] Chemical chaperone therapy : luciferase assay for screening of β-galactosidase mutations.2010
- Author(s)
  Li L., Higaki K., Ninomiya H., Luan Z., Iida M., Ogawa S., Suzuki Y., Ohno K., Nanba E.
- Journal Title
  
  Mol.Genet.Metab. 101
  
  Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Intracerebral cell transplantation therapy for murine GM1 gangliosidosis.2009
- Author(s)
  Sawada T, Tanaka A, Higaki K, Takamura A, Nanba E, Seto T, Maeda M, Yamaguchi E, Matsuda J, Yamano T
- Journal Title
  
  Brain Dev 31
  
  Pages: 717-724
- NAID
  10026412886
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)Deoxynojirimycin.2009
- Author(s)
  Luan Z, Higaki K, Aquilar-Moncayo M, Ninomiya H, Ohno K, Garcia-Moreno MI, Ortiz Mellet C, Garcia Fernandez JM, Suzuki Y
- Journal Title
  
  ChemBioChem 10
  
  Pages: 2789-2792
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin.2009
- Author(s)
  Luan Z., Higaki K., Aguilar-Moncayo M., Ninomiya H., Ohno K., Garcia-Moreno M.I., Ortiz M.C., Garcia Fernandez J.M., Suzuki Y.
- Journal Title
  
  Chembiochem. 23
  
  Pages: 2780-2792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article]2009
- Author(s)
  檜垣克美、難波栄二
- Journal Title
  
  生体の科学特集脳と糖脂質「ガングリオシド蓄積症とシグナル伝達」((財)金原一郎記念医学医療振興財団/医学書院)
  
  Pages: 210-216
- Data Source
  KAKENHI-PROJECT-21659257
[Journal Article] Inhibition of autophagosome formation restores mitochondrial function in mucolipidosis II and III skin fibroblasts.2009
- Author(s)
  Otomo T, Higaki K, Nanba E, Ozono K, Sakai N
- Journal Title
  
  Mol Genet Metab 98
  
  Pages: 393-399
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] Enhanced autophay and mitochondrial aberrations in murone GM1-gangliosidosis. Biochem2008
- Author(s)
  Takamura A, Higaki K, Kajimaki K, Otsuka S, Ninomiya H, Matsuda J,Ohno K, Suzuki Y, Nanba E
- Journal Title
  
  Biophys Res. Commun 367
  
  Pages: 616-622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Nanba E, A case of galactosialidosis with a homozygous Q49R point mutation2008
- Author(s)
  Matsumoto M, Gondo K, Kukita J, Higaki K, Paraguison RC, Nanba E
- Journal Title
  
  Briain Dev 30
  
  Pages: 595-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts.2008
- Author(s)
  Gucev ZS, Tasic V, Jancevska A, Zafrovski G, Kremensky I, Sinergiska I, Nanba E, Higaki K, Suzuki Y1 :
- Journal Title
  
  Am J Med Genet A 146A
  
  Pages: 1736-1740
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] A case of galactosialidosis with a homozygous Q49R point mutation.2008
- Author(s)
  Matsumoto N, Gondo K, Kukita J, Higaki K, Paraguison RC, Nanba E
- Journal Title
  
  Brain Dev 30
  
  Pages: 595-598
- NAID
  10025170220
- Data Source
  KAKENHI-PROJECT-20790728
[Journal Article] Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts2008
- Author(s)
  Gucev ZS, Tasic V, Jancevska A, Zafirovski G, Kremensky I, Sinigerska I, Nanba E, Higaki K, Gucev F, Suzuki Y
- Journal Title
  
  Am, J. Med. Gened 146A
  
  Pages: 1736-1740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Ubiquitin-protease system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy2008
- Author(s)
  Bahrudin U, Morisaki H, Morisaki T, Ninomiya H, Higaki K, Nanba E, Igawa O, Takashima S, Mizuta E, Miake J, Yamamoto Y, Shirayoshi Y, Kitakaze M, Carrier L, Hisatome I
- Journal Title
  
  cardiomyopathy. J. Mol. Biol 384
  
  Pages: 896-907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Intracerebral cell transplantation therapy for murine GM1 gangliosidosis2008
- Author(s)
  Sawada T, Tanaka A, Higaki K, Takamura A, Nanba E, Seto T, Maeda M, Yamaguchi E, Matsuda J, Yamano T
- Journal Title
  
  Brain Dev
- NAID
  10026412886
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Antisense suppression of TSC1 gene product, hamartin2007
- Author(s)
  Floricel F, Higaki K, Maki H, Nanba E, Ninomiya H, Ohno K
- Journal Title
  
  enhances neurite outigrowth in NGF-treated PC12h cells 29
  
  Pages: 502-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Chemical chperone therapy : clinical effect in murine GM1-gangliosidosis2007
- Author(s)
  Suzuki Y, Ichinomiya S, Kurosawa M, Ohkubo M, Watanabe H, Iwasaki H, Matsuda J, Noguchi Y, Takimoto K, Itoh M, Tabe M, Iida M, Kubo T, Ogawa S, Nanba E, Higaki K, Ohno K, Brady RO
- Journal Title
  
  Ann. Neurol 62
  
  Pages: 671-675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcription activity and inhibits neuronal differenctiation2007
- Author(s)
  Paraguison RC, Higaki K, Yamamoto K, Matsumoto H, Sasaki T, Kato N, Nanba E
- Journal Title
  
  J. Neurosci Res 85
  
  Pages: 478-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation.2007
- Author(s)
  Paraguison RC, Higaki K, Yamamoto K, Matsumoto H, Sasaki T, Kato N, Nanba E
- Journal Title
  
  J Neurosci Res. 85(3)
  
  Pages: 479-487
- Data Source
  KAKENHI-PROJECT-17659315
[Journal Article] Fibroblast screening for chaperone therapy in beta-galactosidosis.2006
- Author(s)
  Iwasaki H, Watanabe H, Iida M, Ogawa S, Tabe M, Higaki K, Nanba E, Suzuki Y.
- Journal Title
  
  Brain Dev 28・8
  
  Pages: 482-486
- Data Source
  KAKENHI-PROJECT-18390299
[Journal Article] Polyhistidine tract expansions in HOXA1 result in intranuclear aggregation and increased cell death.2005
- Author(s)
  Paraguison RC, Higaki K, Sakamoto Y, Hashimoto O, Miyake N, Matsumoto H, Yamamoto K, Sasaki T, Kato N, Nanba E.
- Journal Title
  
  Biochem Biophys Res Commun 336(4)
  
  Pages: 1033-1039
- Data Source
  KAKENHI-PROJECT-17659315
[Journal Article] Metazoan and microbial models of Niemann-Pick Type C disease.2004
- Author(s)
  Higaki K et al.
- Journal Title
  
  Biochim Biophys Acta 1685
  
  Pages: 38-47
- Data Source
  KAKENHI-PROJECT-16790577
[Journal Article] The TSC1 gene product hamartin interacts with NADE
- Author(s)
  Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K
- Journal Title
  
  Mol Cell Neurosic 35
  
  Pages: 100-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] ライソゾーム病のシャペロン治療の進歩2020
- Author(s)
  檜垣克美
- Organizer
  第６回市民公開フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17K10051
[Presentation] Chaperone therapy for Lysosomal Storage Diseases2019
- Author(s)
  Katsumi Higaki
- Organizer
  2nd Asia-Pacific Lysosomal Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10051
[Presentation] ライソゾーム病に対する薬理シャペロン療法2017
- Author(s)
  檜垣克美
- Organizer
  第90回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10051
[Presentation] シャペロン療法の最新状況2017
- Author(s)
  檜垣克美
- Organizer
  第22回日本ライソゾーム病研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10051
[Presentation] Chaperone therapy for lysosomal storage diseases2016
- Author(s)
  Katsumi Higaki
- Organizer
  The 13th International Congress of Human Genetics
- Place of Presentation
  Kyoto International Conference Center（京都市）
- Year and Date
  2016-04-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461525
[Presentation] Morquio B research: Chaperone therapy2015
- Author(s)
  Katsumi Higaki
- Organizer
  3rd Annual Morquio Conference
- Place of Presentation
  Wilmington, DE, USA
- Year and Date
  2015-07-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461525
[Presentation] ライソゾーム病に対するpH感受性新規シャペロン化合物の開発.2015
- Author(s)
  成田綾、檜垣克美、難波栄二　他
- Organizer
  第57回日本先天代謝異常学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K15391
[Presentation] ライソゾーム病に対するpH依存的に不活化する新規シャペロン化合物の開発2015
- Author(s)
  檜垣克美
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  京王プラザ（東京都）
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26461525
[Presentation] ライソゾーム病に対するpH依存的に不活化する新規シャペロン化合物の開発2015
- Author(s)
  難波栄二檜垣克美
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K15391
[Presentation] ライソゾーム病に対する低分子シャペロン化合物の探索2014
- Author(s)
  檜垣克美
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  タワーホール船堀（東京都）
- Year and Date
  2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-26461525
[Presentation] α－ガラクトシダーゼAに対する新規シャペロン化合物の開発2014
- Author(s)
  檜垣克美
- Organizer
  第56回日本先天代謝異常学会
- Place of Presentation
  江陽グランドホテル（仙台市）
- Year and Date
  2014-11-14
- Data Source
  KAKENHI-PROJECT-26461525
[Presentation] Comparison of two Chaperone candidates for treatment of GM1-gangliosidosis2013
- Author(s)
  Takai T, Higaki K, Suzuki Y, Nanba E
- Organizer
  The 3rd Asian Congress for Inherited Metabolic Diseases / The 55th Annual Meeting for The Japanese Society for Inherited Metabolic Diseases
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25293230
[Presentation] β-ガラクトシダーゼ欠損症に対するシャペロン治療薬の開発2013
- Author(s)
  難波栄二,檜垣克美,髙井知子,由良敬,榊原康文, Carmen Ortiz Mellet, Jose M. Garcia Fernandez,鈴木義之
- Organizer
  第58回日本人類遺伝学会
- Place of Presentation
  仙台
- Year and Date
  2013-11-21
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] β-ガラクトシダーゼ欠損症に対するシャペロン治療薬の開発2013
- Author(s)
  難波栄二, 檜垣克美, 髙井知子, 由良敬, 榊原康文, Carmen Ortiz Mellet, Jose M. Garcia Fernandez, 鈴木義之
- Organizer
  第58回日本人類遺伝学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25293230
[Presentation] Comparison of two Chaperone candidates for treatment of GM1-gangliosidosis2013
- Author(s)
  Takai T, Higaki K, Suzuki Y, Nanba E
- Organizer
  The 3^<rd> Asian Congress for Inherited Metabolic Diseases / The 55^<th> Annual Meeting for The Japanese Society for Inherited Metabolic Diseases
- Place of Presentation
  Chiba
- Year and Date
  2013-11-29
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] NOEV treatment option for Japansese late-onset Krabbe disease2013
- Author(s)
  Hossain MA, Higaki K, Nanba E, Suzuki Y, Ozono K, Sakai N
- Organizer
  The 3^<rd> Asian Congress for Inherited Metabolic Diseases / The 55^<th> Annual Meeting for The Japanese Society for Inherited Metabolic Diseases
- Place of Presentation
  Chiba
- Year and Date
  2013-11-29
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] A novel chaperone compound for G_<M1>-gangliosidosis2012
- Author(s)
  Takai T, Higaki K, Ortiz Mellet C, García Fernández JM, Ohno K, Suzuki Y, Nanba E
- Organizer
  第17回日本ライソゾーム病研究会
- Place of Presentation
  東京
- Year and Date
  2012-10-06
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ヒトI51T変異β-ガラクトシダーゼに有効な新規ケミカルシャペロン化合物の解析.2012
- Author(s)
  高井知子, 檜垣克美, Ortiz Mellet C, Garcia Fernandez JM, 大野耕策, 鈴木義之, 難波栄二
- Organizer
  第54回日本先天代謝異常学会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] ファブリー病ならびにGM1-ガングリオシドーシスに対する新しいシャペロン治療薬の開発2012
- Author(s)
  難波栄二, 檜垣克美,高井知子, Yu Yi, 大野耕策, 鈴木義之
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] ヒトI51T変異β-ガラクトシダーゼに有効な新規ケミカルシャペロン化合物の解析2012
- Author(s)
  髙井知子,檜垣克美, Ortiz Mellet C, García Fernández JM,大野耕策,鈴木義之,難波栄二
- Organizer
  第54回日本先天代謝異常学会
- Place of Presentation
  岐阜
- Year and Date
  2012-11-16
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ファブリー病ならびにGM1-ガングリオシドーシスに対する新しいシャペロン治療薬の開発2012
- Author(s)
  難波栄二,檜垣克美,髙井知子, Yu Yi,大野耕策,鈴木義之
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  東京
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ライソゾーム病に対するシャペロン化合物の開発2012
- Author(s)
  檜垣克美
- Organizer
  第1回日本シャペロン療法研究会
- Place of Presentation
  東京
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1-gangliosidosis.2012
- Author(s)
  Yu Y ,Higaki K,Takai T, Ortiz Mellet C, Garcia Fernandez JM, Ohno K, Suzuki Y, Nanba E
- Organizer
  第17回ライソゾーム病研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] ライソゾーム病神経変性とミトコンドリア異常2011
- Author(s)
  三浦弘子,檜垣克美,山内裕子, 高井知山内裕子, 高井知
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] GM1ガングリオシドーシスモデルマウス脳におけるシグナル伝達異常2011
- Author(s)
  檜垣克美
- Organizer
  第16回日本ライソゾーム病シンポジウム
- Place of Presentation
  東京慈恵会医科大学(東京都)
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] Chemical chaperone therapy for β-galactosidase deficiency2011
- Author(s)
  Higaki K
- Organizer
  12^<th> International Congress of Human Genetics
- Place of Presentation
  Montreal Convention Center (Montreal, Canada)
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] Chemical chaperone therapy for beta-galactosidase deficiency.2011
- Author(s)
  Higaki K, Ohno K, Suzuki Y, Nanba E.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Galveston, TX, USA
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ベータガラクトシダーゼに対する新規シャペロン候補化合物の解析2011
- Author(s)
  高井知子,檜垣克美, Ortiz Mellet C, Garcia Fernandez J,大野耕策,鈴木義之,難波栄二
- Organizer
  第53回日本先天代謝異常学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ベータガラクトシダーゼに対する新規シャペロン候補化合物の解析2011
- Author(s)
  高井知子,檜垣克美,Ortiz Mellet C, Garcia Fernandez J, 大野耕策, 鈴木義之, 難波栄二
- Organizer
  第53回日本先天代謝異常学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] GM1ガングリオシドーシスモデルマウス脳におけるシグナル伝達異常2011
- Author(s)
  檜垣克美, 高村歩美, 大野耕策, 鈴木義之, 難波栄二
- Organizer
  第16回日本ライソゾーム病シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] ヒト変異β-ガラクトシダーゼに対する新規シャペロン化合物2011
- Author(s)
  高井知子,檜垣克美,鈴木義之、難波栄二
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] GM1ガングリオシドーシスモデルマウス脳におけるシグナル伝達異常.2011
- Author(s)
  檜垣克美
- Organizer
  第16回日本ライソゾーム病研究会
- Place of Presentation
  東京慈恵会医科大学（東京都）
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ヒト変異β-ガラクトシダーゼに対する新規シャペロン化合物2011
- Author(s)
  高井知子、檜垣克美、鈴木義之、難波栄二
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] Chemical chaperone therapy forβ-galactosidase deficiency2011
- Author(s)
  Higaki K, Ohno K, Suzuki Y, Nanba E
- Organizer
  12^<th> International Congress of Human Genetics
- Place of Presentation
  Montreal, Canada
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] Chemical chaperone therapy : chaperone effect on mutant enzyme and cellular pathophysiology inβ-galactosidase deficiency2011
- Author(s)
  Takai T, Higaki K, Ohno K, Suzuki Y, Nanba E
- Organizer
  Satellite Symposium of Asian Congress for Inherited Metabolic Diseases 2011 Tokyo Meeting on Lysosomal Storage Disease Screening
- Place of Presentation
  Tokyo
- Year and Date
  2011-08-05
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ファブリー病に対する新規シャペロン候補化合物の解析2011
- Author(s)
  Yi Y,檜垣克美,Ortiz Mellet C,Garcia Fernandez J, 大野耕策, 鈴木義之, 難波栄二
- Organizer
  第53回日本先天代謝異常学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] Chemical chaperone therapy for beta-galactosidase deficiency2011
- Author(s)
  Higaki K
- Organizer
  Gordon Research Conference
- Place of Presentation
  Hotel Galvez (Galveston, TX, USA)
- Year and Date
  2011-01-25
- Data Source
  KAKENHI-PROJECT-21659257
[Presentation] シャペロン療法の開発戦略2011
- Author(s)
  檜垣克美
- Organizer
  第53回日本先天代謝異常学会総会シンポジウム3 シャペロン療法
- Place of Presentation
  千葉
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] シンポジウム３シャペロン療法, シャペロン療法の開発戦略2011
- Author(s)
  檜垣克美
- Organizer
  第53回日本先天代謝異常学会総会(招待講演)
- Place of Presentation
  ホテルニューオータニ幕張（千葉市）
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] Chemical chaperone therapy for β-galactosidase deficiency.2011
- Author(s)
  Higaki K
- Organizer
  12th International Congress of Human Genetics
- Place of Presentation
  Montreal Convention Center（Montreal, Canada）
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] Chemical chaperone therapy for β-galactosidase deficiency.2011
- Author(s)
  Higaki K, Ohno K, Suzuki Y, Nanba E
- Organizer
  12th International Congress of Human Genetics
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency2011
- Author(s)
  Takai T,Higaki K, Ohno K, Suzuki Y, Nanba E
- Organizer
  Satellite Symposium of Asian Congress for Inherited Metabolic Diseases 2011 Tokyo Meeting on Lysosomal Storage Disease Screening
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] Chemical chaperone therapy for beta-galactosidase deficiency2011
- Author(s)
  Higaki K
- Organizer
  Gordon Research Conference
- Place of Presentation
  Hotel Galvez (Galveston, TX, USA)
- Year and Date
  2011-01-25
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Chemical chaperone therapy for beta-galactosidase deficiency2011
- Author(s)
  Higaki K
- Organizer
  Gordon Research Conference
- Place of Presentation
  Hotel Galvez(Galveston, TX, USA)
- Year and Date
  2011-01-25
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] ファブリー病に対する新規シャペロン候補化合物の解析2011
- Author(s)
  Yi Y,檜垣克美, Ortiz Mellet C, Garcia Fernandez J,大野耕策,鈴木義之,難波栄二
- Organizer
  第53回日本先天代謝異常学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ゴーシェ病に対する蛍光標識薬理学的シャペロンの効果に関する検討2010
- Author(s)
  檜垣克美
- Organizer
  第15回日本ライソゾーム病研究会
- Place of Presentation
  東京慈恵会医科大学(東京都)
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ゴーシェ病に対する蛍光標識薬理学的シャペロンの効果に関する検討2010
- Author(s)
  檜垣克美、〓卓、李林静、難波栄二、大野耕策
- Organizer
  第15回日本ライソゾーム病シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] GM1-ガングリオシドーシス脳神経細胞内のユビキチン化蛋白質の蓄積2010
- Author(s)
  難波栄二、檜垣克美
- Organizer
  第52回日本小児神経学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] ベータガラクトシダーゼに対するシャペロン活性測定のための新規細胞系の構築2010
- Author(s)
  高井知子、檜垣克美、李林静、飯田真己、大野耕策、鈴木義之、難波栄二
- Organizer
  第52回日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ヒト変異β-ガラクトシダーゼに対するシャペロン効果2010
- Author(s)
  高井知子、檜垣克美、李林静、榊原康文、鈴木義之、難波栄二
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ゴーシェ病に対する蛍光標識薬理学的シャペロンの効果に関する検討2010
- Author(s)
  檜垣克美
- Organizer
  第5回日本ライソゾーム病研究会
- Place of Presentation
  東京慈恵会医科大学(東京都)
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22390207
[Presentation] GM1-ガングリオシドーシス脳神経細胞内のユビキチン化蛋白質の蓄積2010
- Author(s)
  難波栄二、檜垣克美
- Organizer
  第52回日本小児神経学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ゴーシェ病に対する蛍光標識薬理学的シャペロンの効果に関する検討2010
- Author(s)
  檜垣克美、〓卓、李林静、難波栄二、大野耕策、Carmen Ortiz Mellet、Jose M.Garcia Fernandez、鈴木義之
- Organizer
  第15回日本ライソゾーム病シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] GM1ガングリオシドーシスモデルマウス脳におけるシグナル伝達異常2010
- Author(s)
  檜垣克美,高村歩美,大野耕策,鈴木義之,難波栄二
- Organizer
  第16回日本ライソゾーム病シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-23591498
[Presentation] ゴーシェ病に対する蛍光標識薬理学的シャペロンの効果に関する検討2010
- Author(s)
  檜垣克美
- Organizer
  第15回日本ライソゾーム病研究会
- Place of Presentation
  東京慈恵会医科大学(東京都)
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21659257
[Presentation] GM1-ガングリオシドーシスとオートファジー異常2009
- Author(s)
  高井知子、檜垣克美、高村歩美、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Screening for chemical chaperone therapy in beta-galactosidosis.2009
- Author(s)
  Li L, Higaki K, Matsuda J, Iida M,Suzuki Y, Nanba E
- Organizer
  第3回国際ライソゾーム病シンポジウム,第14回日本ライソゾーム病シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] GM1-ガングリオシドーシスに対するケミカルシャペロン療法:88種類のミスセンス変異に対するNOEVの効果2009
- Author(s)
  難波栄二, 檜垣克美, 鈴木義之
- Organizer
  第51回日本小児神経学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Screening of chemical chaperone effect for GM1-gangliosidosis.2009
- Author(s)
  Higaki K
- Organizer
  11^<th> ICIEM
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Cellular dysfunction in murine GM1-gangliosidosis.2009
- Author(s)
  Higaki K
- Organizer
  第3回国際ライソゾーム病シンポジウム、第14回日本ライソゾーム病シンポジウム
- Place of Presentation
  名古屋能楽堂(名古屋市)
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-21659257
[Presentation] Screening of chemical chaperone effect for GM1-gangliosidosis.2009
- Author(s)
  Higaki K, Nanba E, Suzuki Y
- Organizer
  11th ICIEM
- Place of Presentation
  San Diego, CA
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Cellular dysfunction in murine GM1-gangliosidosis.2009
- Author(s)
  Higaki K
- Organizer
  第3回国際ライソゾーム病シンポジウム、第14回日本ライソゾーム病シンポジウム
- Place of Presentation
  名古屋能楽堂(名古屋市)
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Cellular dysfunction in murine GM1-gangliosidosis.2009
- Author(s)
  Higaki K, Takamura A, Li L, MatsudaJ, Suzuki Y, Nanba E
- Organizer
  第3回国際ライソゾーム病シンポジウム、第14回日本ライソゾーム病シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] TSCの分子病態2009
- Author(s)
  檜垣克美
- Organizer
  第51回日本小児神経学会ワークショップ神経皮膚症候群研究の進歩
- Place of Presentation
  米子コンベンションセンター(米子市)
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Screening of chemical chaperone effect for human mutant beta-galactosidase.2009
- Author(s)
  Li L, Higaki K, Adachi K, Matsuda J,Ogawa S, Iida M, Iwasaki H, Suzuki Y, Nanba E.
- Organizer
  第9回アジア・オセアニア小児神経学会
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] NPC1遺伝子欠損CHO 細胞における脂質代謝異常2009
- Author(s)
  池端宏記、檜垣克美、難波栄二
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] Screening of chemical chaperone effect for GM1-gangliosidosis.2009
- Author(s)
  Higaki K
- Organizer
  11^<th> ICIEM
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-21659257
[Presentation] GM1-ガングリオシドーシスに対するケミカルシャペロン療法2009
- Author(s)
  池端宏記、檜垣克美、李林静、飯田真巳、鈴木義之、難波栄二
- Organizer
  第51回日本先天代謝異常学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] b-ガラクトシダーゼ遺伝子変異とケミカルシャペロン療法2008
- Author(s)
  池端宏記、檜垣克美、李林静、飯田真巳、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第50回日本先天代謝異常学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] GM1-ガングリオシドーシスモデルマウスにおけるオートファジーの異常2008
- Author(s)
  檜垣克美、高村歩美、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第50回日本先天代謝異常学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ライソゾーム病神経変性とオートファジーの異常2008
- Author(s)
  檜垣克美、李林静、高村歩美、鈴木義之、難波栄二
- Organizer
  第13回日本ライソゾーム病研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] GM1-ガングリオシドーシスにおける神経細胞膜機能異常とTrk シグナルの亢進2008
- Author(s)
  李林静、檜垣克美、高村歩美、飯田真巳、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第50回日本先天代謝異常学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ヒトβ-ガラクトシダーゼ遺伝子変異とケミカルシャペロン療法2008
- Author(s)
  難波栄二、檜垣克美、足立香織、李林静、飯田真巳、松田潤一郎、鈴木義之
- Organizer
  第53回日本人類遺伝学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] GM1-ガングリオシドーシスとオートファジー機能異常2008
- Author(s)
  難波栄二、檜垣克美
- Organizer
  第50回日本小児神経学総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ライソゾーム病神経変性とオートファジーの異常2008
- Author(s)
  檜垣克美、李林静、高村歩美、鈴木義之、難波栄二
- Organizer
  第13回日本ライソゾーム病研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスとオートファジー機能異常2008
- Author(s)
  難波栄二、檜垣克美
- Organizer
  第50回日本小児神経学総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] G_<M1>-ガングリオシドーシスモデルマウスにおけるオートファジーの異常2008
- Author(s)
  檜垣克美、高村歩美、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第50回日本先天代謝異常学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスにおけるオートファジーの異常2008
- Author(s)
  檜垣克美
- Organizer
  第50回日本先天代謝異常学会
- Place of Presentation
  米子
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] G_<M1>-ガングリオシドーシスにおける神経細胞膜機能異常とTrkシグナルの亢進2008
- Author(s)
  李林静、檜垣克美、高村歩美、飯田真巳、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第50回日本先天代謝異常学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] ヒト・-ガラクトシダーゼ遺伝子変異とケミカルシャペロン療法2008
- Author(s)
  難波栄二、檜垣克美、足立香織、李林静、飯田真巳、松田潤一郎、鈴木義之
- Organizer
  第53回日本人類遣伝学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスにおけるオートファジーの異常2008
- Author(s)
  檜垣克美
- Organizer
  第50回日本先天代謝異常学会
- Place of Presentation
  米子
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-20790728
[Presentation] ・-ガラクトシダーゼ遺伝子変異とケミカルシャペロン療法2008
- Author(s)
  池端宏記、檜垣克美、李林静、飯田真巳、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第50回日本先天代謝異常学会総会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスモデルマウスに対するケミカルシャペロン療法の臨床効果2007
- Author(s)
  一ノ宮悟史、黒澤美枝子、飯田真巳、檜垣克美、鈴木義之
- Organizer
  第49回日本先天代謝異常学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスに対するケミカルシャペロン療法のマウスモデル細胞を用いた解析2007
- Author(s)
  檜垣克美, 他
- Organizer
  第49回日本先天代謝異常学会
- Place of Presentation
  山形
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] Lysosomal storage and enhanced signaling of Trk receptors in the neurons of GM1-gangliosidosis mouse brain2007
- Author(s)
  Higaki K., et. al.
- Organizer
  International Symposium of Lysosomal Storage Diseases
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] Lysosomal storage and enhanced signaling of Trk receptors in the neof GM1-gangliosidosis mouse brain2007
- Author(s)
  Higaki K, Takamura A, Suzuki Y, E
- Organizer
  International Symposium of Lysosomal Storage Diseases
- Place of Presentation
  Tokyo
- Year and Date
  2007-12-01
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスに対するケミカルシャペロン療法のマウスモデル細胞を用いた解析2007
- Author(s)
  檜垣克美, 他
- Organizer
  第49回日本先天代謝異常学会
- Place of Presentation
  山形
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-18790719
[Presentation] G^<M1>-ガングリオシドーシスに対するケミカルシャペロン療法のマウスモデル細胞を用いた解析2007
- Author(s)
  檜垣克美、高村歩美、梶巻賢哉、飯田真巳、鈴木義之、難波栄二
- Organizer
  第49回日本先天代謝異常学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] Lysosomal storage and enhanced signaling of Trk receptors in the neurons of GM1-gangliosidosis mouse brain2007
- Author(s)
  Higaki K., et. al.,
- Organizer
  International Symposium of Lysosomal Storage Diseases
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-18790719
[Presentation] 細胞移植によるライソゾーム病脳病変の長期治療の可能性についての検討2007
- Author(s)
  澤田智、田中あけみ、瀬戸俊之、前田光代、高村歩美、檜垣克美、難波栄二、松田潤一郎、山口悦子、山野恒一
- Organizer
  第49回日本先天代謝異常学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] ・-ガラクトシダーゼ欠損症の神経変性におけるTrk受容体の機能異常2007
- Author(s)
  高村歩美、檜垣克美、松田潤一郎、飯田真巳、鈴木義之、難波栄二
- Organizer
  第30回神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] DNAマイクロアレイを用いたGM1-ガングリオシドーシス神経変性機構の解明2007
- Author(s)
  難波栄二、檜垣克美
- Organizer
  第49回日本小児神経学総会
- Place of Presentation
  大阪
- Year and Date
  2007-05-07
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] GM1-ガングリオシドーシスに対するケミカルシャペロン療法の分子解析2006
- Author(s)
  野中和香子、檜垣克美、高村歩美、飯田真巳、小川誠一郎、岩崎浩之、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第12回日本ライソーム病研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] G^<M1>-ガングリオシドーシス神経変性におけるTrk受容体の機能異常2006
- Author(s)
  高村歩美、檜垣克美、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第29回日本神経科学大学
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] -ガラクトシダーゼ欠損症遺伝子変異とケミカルシャペロン療法の検討2006
- Author(s)
  檜垣克美、高村歩美、山本浩一、飯田真巳、小川誠一郎、岩崎浩之、松田潤一郎、鈴木義之、難波栄二
- Organizer
  第51回日本人類遣伝学会大会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] ライソゾーム病の脳病変に対する細胞治療2006
- Author(s)
  澤田智、田中あけみ、前田光代、直原育久代、瀬戸俊之、松田潤一郎、國枝孝典、高野薫、難波栄二、檜垣克美、高村歩美、山口悦子、山野恒一
- Organizer
  第50回日本人類遣伝学会大会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] Analysis of the chemmicl eeffect ochaperone on human mutant2006
- Author(s)
  Higaki K, Takamura A, Matsuda J, Ogawa S, Iida M, Iwasaki H, Suzuki Y, NanbE
- Organizer
  galactosidase expressing mouse cells. The 10^<th> International Congress of Inborn Errors of Metabolis
- Place of Presentation
  (ICIEM), Chiba, Japan
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] Impairment of Trk signaling in G^<M1>-gangliosidosis mice brains2006
- Author(s)
  Takamura A, Higaki K, Matsuda J, Suzuki Y, Nanba E
- Organizer
  The 10^<th> International Congress of Inborn Errors of Metabolis
- Place of Presentation
  (ICIEM), Chiba, Japan
- Data Source
  KAKENHI-PROJECT-18390299
[Presentation] ライソゾーム病に対するシャペロン化合物の開発
- Author(s)
  檜垣克美
- Organizer
  第１回　日本シャペロン療法研究会
- Place of Presentation
  キャンパス・イノベーションセンター東京（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23591498

1. NANBA Eiji (40237631)

# of Collaborated Projects: 9 results

# of Collaborated Products: 59 results
2. ADACHI Kaori (50609237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OHNO Kousaku (70112109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 前川真治 (70314606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NINOMIYA Haruaki (80212124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. KAWATA YASUSHI (40177697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OOBAYASHI Tetsuya (80348804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Okazaki Tetsuya (30465299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐々木司 (50235256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松本英夫 (90199886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山本謙司 (10287071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 榊原康文 (10287427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐治眞理 (50114179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. GOTO Yu-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IRIE Tetsumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. ISHITSUKA Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. TAKEO Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. KONDO Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGAKI Katumi 檜垣 克美

桧垣 克美 ヒガキ カツミ

HIGAKI Katsumi 檜垣 克美

Research Projects

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Co-Researchers

ライソゾーム病に対するシャペロン併用療法による新規治療法の開発Principal Investigator

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Development of novel allosteric chaperone therapy for lysosomal storage diseasesPrincipal Investigator

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Identification of novel chaperones for neurodegerative mucopolysaccharidosesPrincipal Investigator

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TFEB mediated therapy for lysosomal storage diseasesPrincipal Investigator

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Molecular analysis of chemical chaperone effect on lysosomal storage diseasesPrincipal Investigator

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Microarray analysis and development of a novel molecular targeted therapy for neurodegenerative lysosomal storage diseases.Principal Investigator

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HIGAKI Katumi 檜垣克美

桧垣克美ヒガキカツミ

HIGAKI Katsumi 檜垣克美

[Book] GM1-ガングリオシドーシス（先天代謝異常症候群第2版)2012

[Book] GM1-ガングリオシドーシス.先天代謝異常症候群第2版2012

[Book] GM1-ガングリオシドーシス（先天代謝異常症候群第2版2012