Omote Masaaki 表雅章

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OMOTE Masaaki 表雅章

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Researcher Number	90299032
Other IDs
Affiliation (Current)	2025: 摂南大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 摂南大学, 薬学部, 教授 2019 – 2023: 摂南大学, 薬学部, 教授 1998 – 2003: 摂南大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator 医薬分子機能学
Keywords	Principal Investigator シメチジン / 阻害剤 / 多剤排出ポンプ / MATE1 / 歯周病菌 / アニリン誘導体 / 蛍光プローブ / プロリルトリペプチジルアミノペプチダーゼ / 酵素活性プローブ / アニリン … More / フッ素 / 小分子 / トリフルオロメチル基 / 蛍光性化合物 … More Except Principal Investigator Vitamin E / 含フッ素脂肪酸 / ホスファチジルコリン / リポソーム / フッ素 / ビタミンE / Difluoromethylene / Trifluoromethyl / Fluorinated fatty acid / Biodynamic behavior / Liposome / Fluorine / Phosphatidyl choline / ジフルオロメチレン / トリフルオロメチル / 体内動態 / phosphatidylcholine / fatty acid / mobility / relaxation time / ィイD119ィエD1F-NMR / liposome / fluorine / ホスファチジルコン / フッ素NMR / 脂肪酸 / 可動性 / 緩和時間 / ^<19>F-NMR Less

フッ化スルホニル基の超効率的合成法の開発とPET利用に向けた18F化への展開Principal Investigator
- Principal Investigator
  
  表雅章
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Setsunan University
多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出Principal Investigator
- Principal Investigator
  
  表雅章
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Setsunan University
Development of small molecule fluorescent compounds and elaboration of fluorescent probe for periodontal bacteriaPrincipal Investigator
- Principal Investigator
  
  Omote Masaaki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Setsunan University
Preparation of liposome membranes with fluorine atoms as marker for study of behavior of vitamin E in biological membaranes
- Principal Investigator
  
  KUMADAKI Itsumaro
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  SETSUNAN UNIVERSITY
STUDY ON BEHAVIOR OF VITAMIN E IN BIOLOGICAL MEMBRANE MODEL USING FLUORINE AS PROBE
- Principal Investigator
  
  KUMADAKI Itsumaro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Setsunan University

All 2024 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria2024
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 99 Pages: 117606-117606
- DOI
  10.1016/j.bmc.2024.117606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06514, KAKENHI-PROJECT-23K06125, KAKENHI-PROJECT-20K07059
[Journal Article] Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections2022
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 74 Pages: 117042-117042
- DOI
  10.1016/j.bmc.2022.117042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07059, KAKENHI-PROJECT-22K06514
[Journal Article] Synthesis of Small Fluorescent Molecules and Evaluation of Photophysical Properties2020
- Author(s)
  Futa Ogawa, Yukiko Karuo, Ryuji Yamazawa, Kanae Miyanaga, Kazushige Hori, Keita Tani, Kengo Yamada, Yuki Saito, Kazumasa Funabiki, Atsushi Tarui, Kazuyuki Sato, Kiyoshi Ito, Kentaro Kawai, and Masaaki Omote*
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 85 Issue: 2 Pages: 1253-1258
- DOI
  10.1021/acs.joc.9b02857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05740, KAKENHI-PROJECT-17K05974
[Presentation] 細菌MATE型薬剤排出ポンプ阻害剤の探索合成と活性評価2023
- Author(s)
  新屋　進、河合健太郎、小林直木、軽尾友紀子、樽井　敦、佐藤和之、大塚正人、表　雅章
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 細菌抗菌薬排出機構MATE型輸送体の新規阻害剤の探索合成と活性評価2023
- Author(s)
  新屋進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井敦, 佐藤和之, 大塚正人, 表雅章
- Organizer
  第46回フッ素化学討論会
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] Exploration and Synthesis of Inhibitors Targeting the Bacterial Multidrug Efflux Pump MATE-type transporter2023
- Author(s)
  新屋進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井敦, 佐藤和之, 大塚正人, 表雅章
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] Development of Selective Inhibitors Targeting Multi-antimicrobial extrusion transporter to Overcome Antibiotic Resistance2023
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Organizer
  23rd International Symposium on Fluorine Chemistry (ISFC) and the 9th International Symposium on Fluorous Technologies (ISoFT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 細菌多剤排出輸送体MATE阻害化合物の探索合成と活性評価2022
- Author(s)
  新屋　進、河合健太郎、小林直木、軽尾友紀子、樽井　敦、佐藤和之、大塚正人、表　雅章
- Organizer
  日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 多剤耐性菌に有効な細菌選択的MATE 型輸送体阻害剤（SS-322）の創生2022
- Author(s)
  新屋　進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井　敦, 佐藤和之, 大塚正人, 表　雅章
- Organizer
  創薬懇話会 2022 in名古屋
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 多剤耐性菌に有効な細菌選択的MATE型輸送体阻害剤の創生2022
- Author(s)
  新屋　進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井　敦, 佐藤和之, 大塚正人, 表　雅章
- Organizer
  第42回有機合成若手セミナー
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 歯周病菌産生酵素活性測定用プローブ合成と活性評価2022
- Author(s)
  軽尾友紀子、東野崇太、樽井敦、佐藤和之、山澤龍治、伊藤潔、河合健太郎、表雅章
- Organizer
  日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K05740
[Presentation] 歯周病菌の蛍光プローブ創製2022
- Author(s)
  軽尾友紀子、東野崇太、樽井敦、佐藤和之、河合健太郎、表雅章
- Organizer
  第45回フッ素化学討論会
- Data Source
  KAKENHI-PROJECT-19K05740
[Presentation] 2-Trifluoropropenylanilineを基本骨格とする低分子蛍光性有機化合物の合成と利用2019
- Author(s)
  小川風太、軽尾友紀子、谷敬太、樽井敦、佐藤和之、河合健太郎、表雅章
- Organizer
  第45回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19K05740

1. KUMADAKI Itsumaro (20057326)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 軽尾友紀子 (30826235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. 河合健太郎 (60826246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. ANDO Akira (20138960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SATO Kazuyuki (10319791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊藤潔 (50201926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 船曳一正 (50273123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 谷敬太 (60207165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 大塚正人 (30243489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. 小林直木

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Omote Masaaki 表 雅章

OMOTE Masaaki 表 雅章

Research Projects

Research Products

Co-Researchers

フッ化スルホニル基の超効率的合成法の開発とPET利用に向けた18F化への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of small molecule fluorescent compounds and elaboration of fluorescent probe for periodontal bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Preparation of liposome membranes with fluorine atoms as marker for study of behavior of vitamin E in biological membaranes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY ON BEHAVIOR OF VITAMIN E IN BIOLOGICAL MEMBRANE MODEL USING FLUORINE AS PROBE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Small Fluorescent Molecules and Evaluation of Photophysical Properties2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 細菌MATE型薬剤排出ポンプ阻害剤の探索合成と活性評価2023

Author(s)

Organizer

Data Source

[Presentation] 細菌抗菌薬排出機構MATE型輸送体の新規阻害剤の探索合成と活性評価2023

Author(s)

Organizer

Data Source

[Presentation] Exploration and Synthesis of Inhibitors Targeting the Bacterial Multidrug Efflux Pump MATE-type transporter2023

Author(s)

Organizer

Data Source

[Presentation] Development of Selective Inhibitors Targeting Multi-antimicrobial extrusion transporter to Overcome Antibiotic Resistance2023

Author(s)

Organizer

Data Source

[Presentation] 細菌多剤排出輸送体MATE阻害化合物の探索合成と活性評価2022

Author(s)

Organizer

Data Source

[Presentation] 多剤耐性菌に有効な細菌選択的MATE 型輸送体阻害剤（SS-322）の創生2022

Author(s)

Organizer

Data Source

[Presentation] 多剤耐性菌に有効な細菌選択的MATE型輸送体阻害剤の創生2022

Author(s)

Organizer

Data Source

[Presentation] 歯周病菌産生酵素活性測定用プローブ合成と活性評価2022

Author(s)

Omote Masaaki 表雅章

OMOTE Masaaki 表雅章