NAGANO MOTOKO 長野基子

… Alternative Names

Nagano-Fujii Motoko 長野基子

NAGANO Motoko 長野基子

乙葉基子オトハモトコ

藤井基子フジイモトコ

Less

Researcher Number	90304089
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2016: 兵庫医療大学, 薬学部, 講師 2007: Kobe University, Graduate School of Medicine, Assistant Professor 2005 – 2006: 神戸大学, 大学院医学系研究科, 助手 2001 – 2005: 神戸大学, 大学院・医学系研究科, 助手 1999 – 2000: 神戸大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Environmental and hygienic pharmacy / Virology / Virology Except Principal Investigator Biological Sciences / Virology / Pathological medical chemistry / Virology
Keywords	Principal Investigator C型肝炎ウイルス / IL-8 / 2-5A合成酵素 / 抗ウイルス活性 / インターフェロン / 非構造蛋白NS5A / 肝特異的発現蛋白質 / 細胞障害 / Circumsporozoite protein / 肝特異的発現タンパク質 … More / 細胞増殖 / ETRAMP13 / Circumsprozoite protein / マラリア原虫 / アミノ酸変異 / NS4B / NS4A / HCV RNAレプリコン / シグナル伝達 / 遺伝子多様性 … More Except Principal Investigator C型肝炎ウイルス / hepatitis C virus / インドネシア / NS5A / Indonesia / B型肝炎ウイルス / ISDR / hepatitis B virus / 血中ウイルス量 / 日本 / 原発性肝がん / 発がんリスク / 変異株 / 遺伝子多様性 / チロシンキナーゼ / Syk / インターフェロン / proteome analysis / Svk / signal transduction / virus-host relationship / protein-tyrosine kinase / protein-tvrosine phosphorylation / プロテオーム解析 / シグナル伝達 / ウイルス-宿主間相互作用 / 蛋白質チロシンリン酸化反応 / Japan / hepatocellular carcinoma / carcinogenic risk / mutant / sequence variation / 原発性肝癌 / 発癌リスク / mutation / interferon / viremiatiter / subtype / 変異 / サブタイプ / viremia titer / molecularepidemiology / hepatitis D virus / TT virus / GB virus / 多様性 / 遺伝子型 / 分子疫学 / D型肝炎ウイルス / TTウイルス / GBウイルス / 感染症 / 遺伝子 / ウイルス / 細胞内輸送 / ELKS蛋白 / トランスアクチベーション / p53癌抑制蛋白 / セリンプロテアーゼ / NS3 / HCVレプリコン / Protein kinase B / Akt / 2'-5'オリゴアデニル酸合成酵素 / 点突然変異 / コア蛋白 / レプリコン Less

Analysis of influence of hepatitis C virus and Plasmodium falciparum proteins specifically expressed at liver on growth of HCV and P. falciparum.Principal Investigator
- Principal Investigator
  
  Nagano-Fujii Motoko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Hyogo University of Health Sciences
C型肝炎ウイルスの増殖適応変異と病原性の研究
- Principal Investigator
  
  堀田博
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Effects of hepatitis C virus proteins on protein-tyrosine phosphorylation in liver cells
- Principal Investigator
  
  SADA Kiyonao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
レプリコンを用いたC型肝炎ウイルス・宿主間相互作用の分子機序に関する研究
- Principal Investigator
  
  堀田博
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
インドネシアにおける発がんリスクの高いB型及びC型肝炎ウイルスの分子疫学的研究
- Principal Investigator
  
  堀田博
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Study on possible correlation between carcinogenic risk and genetic variation of hepatitis B and C viruses in Indonesia.
- Principal Investigator
  
  HOTTA Hak
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Kobe University
レプリコンを用いたC型肝炎ウイルス・宿主間相互作用の分子機序に関する研究
- Principal Investigator
  
  HOTTA HAK
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
C型肝炎ウイルスNS5A蛋白によるインターフェロン阻害作用の分子機序の研究Principal Investigator
- Principal Investigator
  
  長野基子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kobe University
Viral factors that determine viremia titers of hepatitis C virus in Indonesia
- Principal Investigator
  
  HOTTA Hak
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Kobe University
C型肝炎ウイルスNS5A蛋白によるインターフェロン抗ウイルス活性の抑制の解析Principal Investigator
- Principal Investigator
  
  長野基子 (乙葉基子 / 藤井基子)
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Kobe University
Molecular epidemiology of hepatitis viruses in Indonesia
- Principal Investigator
  
  HOTTA Hak
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Virology
- Research Institution
  Kobe University

All 2016 2015 2014 2007 2006 Other

All Journal Article Presentation

[Journal Article] Continuous in vivo culture and indirect fluorescent antibody test for zoonotic protozoa of Babesia microti.2016
- Author(s)
  Saito-Ito A, Kawai A, Ohmori S, Nagano-Fujii M.
- Journal Title
  
  Parasitol Int.
  
  Volume: 65 Issue: 5 Pages: 526-531
- DOI
  10.1016/j.parint.2016.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460181
[Journal Article] Development of absolute quantification method for genotype-specific Babesia microti using real-time PCR and practical experimental tips of real-time PCR.2016
- Author(s)
  Ohmori S, Nagano-Fujii M, Saito-Ito A.
- Journal Title
  
  Parasitol Int.
  
  Volume: 65 Issue: 5 Pages: 567-571
- DOI
  10.1016/j.parint.2016.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460181
[Journal Article] The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway2006
- Author(s)
  Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S., Sada, K., Hotta, H
- Journal Title
  
  J. Gen. Virol 87(7)
  
  Pages: 1935-1945
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference2006
- Author(s)
  Otaki, M., Sada, K., Kadoya, H., Nagano-Fujii, M., Hotta, H
- Journal Title
  
  Antiviral Res 70(3)
  
  Pages: 105-111
- NAID
  120000945629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] The NS3 protein of hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner2006
- Author(s)
  Deng, L., Nagano-Fujii, M., Tanaka, M., Nomura-Takigawa, Y., Ikeda, M., Kato, N., Sada. K., Hotta, H
- Journal Title
  
  J. Gen. Virol 87(6)
  
  Pages: 1703-1713
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS32006
- Author(s)
  Tanaka, M., Nagano-Fujii, M., Deng, L., Ishido, S., Sada, K., Hotta, H
- Journal Title
  
  Biochem. Biophys. Res. Commun 340(3)
  
  Pages: 792-799
- NAID
  120000943971
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE2006
- Author(s)
  Hotta, H., Nihei, K., Abe, Y., Kato, S., Jiang D. P., Nagano-Fujii, M., Sada, K
- Journal Title
  
  Microbiol. Immunol 50(7)
  
  Pages: 525-534
- NAID
  10017991849
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk
- Author(s)
  Inubushi, S., Nagano-Fujii, M., Kitayama, K., Tanaka, M., An, C., Yokozaki, H., Yamamura, H., Nuriya, H., Kohara, M., Sada, K., Hotta, H
- Journal Title
  
  J. Gen. Virol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] ヒトバベシア症発生国台湾（高尾県）のヒトバベシア症疫学調査結果続報2016
- Author(s)
  斎藤あつ子、河合敦子、大森志保、長野基子、蔡季君、陳彦旭、余明隆、陳栄霖
- Organizer
  第85回日本寄生虫学会大会
- Place of Presentation
  宮崎市民プラザ（宮崎県宮崎市）
- Year and Date
  2016-03-20
- Data Source
  KAKENHI-PROJECT-25460181
[Presentation] 兵庫県捕獲マダニについてのバベシア属原虫感染調査2016
- Author(s)
  大森志保、長野基子、斎藤あつ子
- Organizer
  第85回日本寄生虫学会大会
- Place of Presentation
  宮崎市民プラザ（宮崎県宮崎市）
- Year and Date
  2016-03-20
- Data Source
  KAKENHI-PROJECT-25460181
[Presentation] ヒトバベシア症発生国台湾のヒトバベシア症疫学調査結果2015
- Author(s)
  斎藤あつ子、河合敦子、大森志保、長野基子、栗山卓也、淺海裕、蔡季君、陳彦旭、余明隆、陳栄霖
- Organizer
  第84回日本寄生虫学会大会
- Place of Presentation
  杏林大学三鷹キャンパス　(東京都三鷹市）
- Year and Date
  2015-03-22
- Data Source
  KAKENHI-PROJECT-25460181
[Presentation] 高知県のイノシシに寄生が認められたイノシシ特有のバベシア属原虫について2015
- Author(s)
  大森志保、河合敦子、長野基子、佐藤ー美甘江利子、富田茉莉、増山敦子、榊久実、荻野慶隆、今村京子、鈴木和男、是永正敬、斎藤あつ子
- Organizer
  第84回日本寄生虫学会大会
- Place of Presentation
  杏林大学三鷹キャンパス　(東京都三鷹市）
- Year and Date
  2015-03-22
- Data Source
  KAKENHI-PROJECT-25460181
[Presentation] 和歌山県に続き高知県のイノシシに寄生が認められたイノシシ特有のバベシア属原虫について2014
- Author(s)
  大森志保、河合敦子、長野基子、佐藤ー美甘江利子、富田茉莉、増山敦子、榊久実、荻野慶隆、今村京子、鈴木和男、是永正敬、斎藤あつ子
- Organizer
  第70回日本寄生虫学会西日本支部大会
- Place of Presentation
  兵庫医療大学　(兵庫県神戸市）
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-25460181
[Presentation] Glucose uptake and GLUTI/2 expression are down -regulated in Huh-7.5 cells harboring an HCV subgenomic RNA replicon and full-genomic RNA replicon2007
- Author(s)
  Kasai, D., Nagano-Fujii, M., Bungyoku, Y., Sasayama, M., Sada. K., Hotta, H
- Organizer
  14th International Symposium on Hepatitis Virus and Related Viruses
- Place of Presentation
  Glasgow, UK
- Year and Date
  2007-09-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] 慢性C型肝炎に対するペグインターフェロン/リバビリン併用療法の早期治療効果とC型肝炎ウイルスNS5AのV3領域アミノ酸配列多様性の相関について.2006
- Author(s)
  長野基子
- Organizer
  第42回日本肝臓学会総会
- Place of Presentation
  京都
- Year and Date
  2006-05-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] Kinase activity of the non-receptor tyrosine kinase Syk is down-regulated in Huh-7.5 cells harboring an HCV RNA subgenomic replicon2006
- Author(s)
  Inubushi, S., Nagano-Fujii, M., Kitayama, K., Yamamura, H., Sada, K., Hotta, H
- Organizer
  13th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Sydney, Australia
- Year and Date
  2006-08-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] ペグインタ-フェロン/リバビリン併用療法無効例とHCV NS5AのV3領域アミノ酸配列多様性及びNS5A抗体の有無との相関.2006
- Author(s)
  長野基子
- Organizer
  第10回日本肝臓学会大会
- Place of Presentation
  札幌
- Year and Date
  2006-10-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] A high degree of sequence variation of HCV NS5A and the presence of anti-NS5A antibodies in the pretreatment sera are associated with efficient viral clearance by combination therapy using pegylated interferon and ribavirin2006
- Author(s)
  El-Shamy, A., Sasayama, M., Nagano-Fujii, M., Sada, K., Kim, S. R., Hotta, H
- Organizer
  13th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Sydney, Australia
- Year and Date
  2006-08-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293

1. HOTTA HAK (40116249)

# of Collaborated Projects: 9 results

# of Collaborated Products: 9 results
2. OHGIMOTO Shinji (80292853)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. SADA Kiyonao (10273765)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. MATSUOKA HIROYUKI (10173816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUJITA Tsunenori (00314477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAWABATA Masato (30175294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ISHIDO Satoshi (10273781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HATANI Tomoko (60452124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 勝二郁夫 (40356241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 足達哲也 (60345014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 斎藤あつ子 (00223131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大森志保 (90379488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
13. 岡清正 (70314474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 斉藤あつ子

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

NAGANO MOTOKO 長野 基子

Nagano-Fujii Motoko 長野 基子

NAGANO Motoko 長野 基子

乙葉 基子 オトハ モトコ

藤井 基子 フジイ モトコ

Research Projects

Research Products

Co-Researchers

Analysis of influence of hepatitis C virus and Plasmodium falciparum proteins specifically expressed at liver on growth of HCV and P. falciparum.Principal Investigator

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C型肝炎ウイルスNS5A蛋白によるインターフェロン阻害作用の分子機序の研究Principal Investigator

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C型肝炎ウイルスNS5A蛋白によるインターフェロン抗ウイルス活性の抑制の解析Principal Investigator

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[Journal Article] Continuous in vivo culture and indirect fluorescent antibody test for zoonotic protozoa of Babesia microti.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of absolute quantification method for genotype-specific Babesia microti using real-time PCR and practical experimental tips of real-time PCR.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway2006

Author(s)

Journal Title

Description

NAGANO MOTOKO 長野基子

Nagano-Fujii Motoko 長野基子

NAGANO Motoko 長野基子

乙葉基子オトハモトコ

藤井基子フジイモトコ