Kato Naoya 加藤直也

… Alternative Names

KATO NAOYA 加藤直也

KATO Naoya 加藤直也

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Researcher Number	90313220
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2023 – 2024: 千葉大学, 大学院医学研究院, 教授 2019 – 2021: 千葉大学, 大学院医学研究院, 教授 2013 – 2014: 東京大学, 医科学研究所, 准教授 2012: 東京大学, 医科学研究所, 特任准教授 2008 – 2010: The University of Tokyo, 医科学研究所, 特任准教授 … More 2009: 東京大学, 医学部附属病院, 助手 2007 – 2008: The University of Tokyo, Hospital, Research Associate 2007: The University of Tokyo, The University of TokyoHospital, Project Lecturer 2007: 東京大学, 医学部附属病院, 特任講師 2002 – 2006: 東京大学, 医学部附属病院, 助手 1999 – 2001: University of Tokyo Faculty of Medicine, Assistant, 医学部・附属病院, 助手 2000: University of Tokyo Hospital, Instructor, 医学部・付属病院, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology / Biological Sciences Except Principal Investigator Gastroenterology / Gastroenterology / Biological Sciences
Keywords	Principal Investigator SNP / UGT1A7 / 肝細胞癌 / 肝癌 / C型肝炎ウイルス / p53 / MxA / 自然免疫 / MICA / PKR … More / 細胞傷害性T細胞 / NK細胞 / RNAi / OAS-1 / MDM2 / Hepatocellular carcinoma / Hepatitis C / C型肝炎 / TLR3 / インターフェロン / B型肝炎ウイルス / Non-inflamed type / Inflamed type / 免疫サブクラス / 制御性T細胞 / 腫瘍免疫微小環境 / 複合免疫療法 / ADAM / PD-L1 / 発癌抑止 / Interferon / Innate immunity / Hepatitis C virus / ノックダウン / Cytokine / GFRA1 / CRHR2 / SCYB14 / サイトカイン / Interleukin-1β / Hepatitis C virus core protein / Hepatitis B virus X protein / Hplotype / B型肝炎ウィルス / インターロイキン8 / c型肝炎ウイルスコア蛋白 / インターロイキン1β / C型肝炎ウイルスコア蛋白 / B型肝炎ウイルスX蛋白 / ハプロタイプ / Interleukin / NF-_KB / Apoptosis / Inflammatory cytokine / Hepatitis delta virus (HDV) / Hepatitis C virus (HCV) / Hepatitis B virus (HBV) / p21 / D型肝炎ウイルス / 翻訳 / Bcl-x_L / MAPK / インターロイキン / NF-κB / アポトーシス / 炎症性サイトカイン / デルタ型肝炎ウイルス / ncRNA / microRNA / プロモーター / SAHA / 薬剤スクリーニング / ゲノムワイド関連解析 / RNA干渉 / 2-5AS / GWAS / コア蛋白 / OAS / Entecavir / MCC-478 / Adefovir / ラミブジン / DNAポリメラーゼ / 逆転写酵素 / 薬剤耐性 … More Except Principal Investigator p53 / NF-κB / C型肝炎ウイルス / DCP / Gemcitabine / Signal transduction / インターフェロン / 持続感染 / 自然免疫 / シグナル伝達 / 肝癌 / 転写因子 / Core / TAF / TBP / NS5A / 化学療法 / 肝細胞癌 / B型肝炎ウイルス / Interferon / Immunology / Infection / Virus / Dicer / RNA interference / Toll-like receptor 3 / PKR / レプリコン / 免疫学 / 感染症 / ウイルス / hepatocellular carcinoma / vitaminK / ビタミンK / Endoscopic ultrasonography / Drug resistance / Microarray / Chemo-sensitivity / Pancreatic carcinoma / 超音波内視鏡 / 薬剤耐性 / マイクロアレイ / 抗癌剤感受性 / 膵癌 / Persistent infection / Innate Immunity / Apoptosis / Hepatitis delta virus / Hepatitis C virus / Hepatitis B virus / SRF / Bcl-Xr / NF-KB / シグナル伝導 / cDNA array / TGF-β / 線維化 / A型肝炎ウイルス / アポトーシス / デルタ型肝炎ウイルス / Radio-frequency ablation / Gene therapy / Chemotherapy / Subcutaneously embedded port for arterial infusion / Percutaneous tumor ablation / Multi-modality therapy / Far advanced hepatocellular carcinoma / 集学的治療 / low dose FP療法 / radiofrequency ablation / 皮下埋込式動注ポート / 経皮的ラジオ波焼灼療法 / 遺伝子治療 / 皮下埋込み式動注ポート / 経皮的局所療法 / 集学的治療法 / 高度進行肝癌 / Transcription / Hepatitis C virus (HCV) / NF-kB / 転写 / 胃癌 / 肝転移 / 大腸癌 / IVR / 進行癌 / Jab1 / AP-1 / 質量分析 / X蛋白 / 肝発癌 Less

Development of all-round combined immunotherapy for advanced hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  加藤直也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Comprehensive Management of Hepatocellular Carcinoma Targeting Innate Immunological Escape of the CancerPrincipal Investigator
- Principal Investigator
  
  Kato Naoya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Functional analysis of MICA in hepatitis C virus-induced hepatocellular carcinoma and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  KATO NAOYA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Interferon stimulated genes and its polymorphisms determining Hepatitis C virus replication and pathogenesis of hepatitis CPrincipal Investigator
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Establishment of new treatment strategy for advanced cancers : evaluation of the combination therapy of interventional radiology and chemotherapy
- Principal Investigator
  
  SHIINA Shuichirou (SHIINA Shuichiro)
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Comprehensive analysis of hepatitis Cvirus protein that disturb host interferon systemPrincipal Investigator
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Inhibition of innate immune system by hepatitis C virus
- Principal Investigator
  
  OMATA Masao
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
B型肝炎ウイルスX蛋白と相互作用する宿主分子の同定と肝発癌の分子機構
- Principal Investigator
  
  金井文彦
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analyses of the individual risk for hepatocellular carcinoma by large scale search of single nucleotide polymorphisms of cytokine genesPrincipal Investigator
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo Hospital
Analyses of molecular mechanisms of hepatocellular carcinoma cell growth suppression induced by vitamin K
- Principal Investigator
  
  TERATANI Takuma
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
B型肝炎ウイルスの逆転写酵素阻害剤耐性の分子基盤とその制御Principal Investigator
- Principal Investigator
  
  加藤直也
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analysis of relationship between chemo-sensitivity and gene expression profile in pancreatic cancer by using specimen obtained by endoscopic ultrasonography guided fine needle aspiration biopsy for clinical application
- Principal Investigator
  
  TADA Minoru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Viral mutations and host diversities that contribute to hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The Unibersity of Tokyo
Mechanism of hepatocyte injury via survival and death signaling induced by hepatitis viruses
- Principal Investigator
  
  OMATA Masao
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Molecular mechanism of inflammatory cytokine induction by hepatitis virusesPrincipal Investigator
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Development of a new multi-modality therapy for far advanced hepatocellular carcinoma : a combined therapy of a new percutaneous local tumor ablation and a chemotherapy using subcutaneously embedded port for arterial infusion or gene therapy
- Principal Investigator
  
  SHIINA Shuichiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Cloning of human proteins which interact with heaptitis C virus proteins
- Principal Investigator
  
  YOSHI Haruhiko, 丹羽泰郎
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

[Book] Hepatitis C virus.(Karayiannis P, Main J, Thomas H eds.)(Hepatocellular carcinoma "epidemics" in Japan.)2009
- Author(s)
  Omata M, Yoshida H, Shiina S, Kato N
- Publisher
  International Medical Press Ltd.
- Data Source
  KAKENHI-PROJECT-20590760
[Book] 肝胆膵診療エキスパートマニュアル2008
- Author(s)
  加藤直也
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590760
[Book] 肝胆膵診療エキスパートマニュアル2008
- Author(s)
  加藤直也,他
- Total Pages
  436
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590760
[Book] 肝疾患Review 2006-20072006
- Author(s)
  加藤直也, ほか
- Total Pages
  301
- Publisher
  日本メディカルセンター
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Book] New antivirals against wild-type and lamivudine-resistant hepatitis B virus. In : Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma. (Omata M, Okita K eds.)2004
- Author(s)
  Kato N, Ono-Nita SK, Omata M.
- Publisher
  Springer-Verlag Tokyo.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Book] Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma2004
- Author(s)
  Kato N et al.
- Publisher
  Springer-Verlag Tokyo
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma.2023
- Author(s)
  Qiang N, Ao J, Nakamura M, Chiba T, Kusakabe Y, Kaneko T, Kurosugi A, Kogure T, Ma Y, Zhang J, Ogawa K, Kan M, Iwanaga T, Sakuma T, Kanayama K, Kanzaki H, Kojima R, Nakagawa R, Kondo T, Nakamoto S, Muroyama R, Kato J, Mimura N, Ma A, Jin J, Kato N.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 118 Pages: 110068-110068
- DOI
  10.1016/j.intimp.2023.110068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-23K27577
[Journal Article] A prospective study exploring the safety and efficacy of lenvatinib for patients with advanced hepatocellular carcinoma and high tumor burden: The LAUNCH study.2023
- Author(s)
  Kobayashi K, Ogasawara S, Kato N, et al.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 55 Issue: 23 Pages: 1072-1080
- DOI
  10.1158/1078-0432.ccr-23-1462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Hyperprogressive disease during atezolizumab plus bevacizumab treatment in patients with advanced hepatocellular carcinoma from Japanese real-world practice2023
- Author(s)
  Yumita S, Ogasawara S, Nakagawa M, Maruta S, Okubo T, et al.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 23 Issue: 1 Pages: 101-101
- DOI
  10.1186/s12876-023-02731-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-23K27577
[Journal Article] Cabozantinib for Advanced Hepatocellular Carcinoma in the Latest Real-World Practice: A Multicenter Retrospective Analysis.2023
- Author(s)
  Kanzaki H, Ogasawara S, Kato N, et al.
- Journal Title
  
  Drugs Real World Outcomes
  
  Volume: 10 Issue: 4 Pages: 513-520
- DOI
  10.1007/s40801-023-00379-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma.2023
- Author(s)
  Kojima R, Kato N, et al.
- Journal Title
  
  World J Virol
  
  Volume: 12 Issue: 3 Pages: 209-220
- DOI
  10.5501/wjv.v12.i3.209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Use of ramucirumab for various treatment lines in real-world practice of patients with advanced hepatocellular carcinoma.2023
- Author(s)
  Kanogawa N, Ogasawara S, Kato N, et al.
- Journal Title
  
  BMC Gastroenterol
  
  Volume: 23 Issue: 1 Pages: 70-70
- DOI
  10.1186/s12876-023-02674-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Estimation of the effect of atezolizumab plus bevacizumab on pulmonary arterial hypertension using computed tomography in HCC patients.2023
- Author(s)
  Kondo T, Ogasawara S, Kato N et al.
- Journal Title
  
  Sci Rep
  
  Volume: 13 Issue: 1 Pages: 11524-11524
- DOI
  10.1038/s41598-023-38377-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27577
[Journal Article] Baseline soluble MICA levels act as a predictive biomarker for the efficacy of regorafenib treatment in colorectal cancer2021
- Author(s)
  Arai J, Otoyama Y, Fujita KI, Goto K, Tojo M, Katagiri A, Nozawa H, Kubota Y, Takahashi T, Ishida H, Tsunoda T, Matsumoto N, Ogawa K, Nakagawa R, Muroyama R, Kato N, Yoshida H.
- Journal Title
  
  BMC Cancer
  
  Volume: 22 Issue: 1 Pages: 428-428
- DOI
  10.1186/s12885-022-09512-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03633
[Journal Article] Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding2021
- Author(s)
  Arai J, Goto K, Otoyama Y, Nakajima Y, Sugiura I, Kajiwara A, Tojo M, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Nozawa H, Nakagawa R, Muroyama R, Kato N, Yoshida H.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 70 Issue: 1 Pages: 203-213
- DOI
  10.1007/s00262-020-02660-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03633, KAKENHI-PROJECT-18K07996, KAKENHI-PROJECT-19K16723
[Journal Article] Retinoids decrease soluble MICA concentration by inhibiting the enzymatic activity of ADAM9 and ADAM102021
- Author(s)
  Otoyama Y, Arai J, Goto K, Nozawa H, Nakagawa R, Muroyama R, Sugiura I, Nakajima Y, Kajiwara A, Tojo M, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Kato N, Yoshida H.
- Journal Title
  
  Anticancer Res
  
  Volume: 41 Issue: 5 Pages: 2307-2320
- DOI
  10.21873/anticanres.15006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Journal Article] MICA SNPs and the NKG2D system in virus-induced HCC.2015
- Author(s)
  Goto K, Kato N.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 3 Pages: 261-272
- DOI
  10.1007/s00535-014-1000-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390184
[Journal Article] The characteristic changes in hepatitis B virus X region for hepatocellular carcinoma: A comprehensive analysis based on global data.2015
- Author(s)
  Li W, Goto K, Matsubara Y, Ito S, Murayama R, Li Q, Kato N.
- Journal Title
  
  PLoS One
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390184
[Journal Article] IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection2014
- Author(s)
  Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K
- Journal Title
  
  J Gastroenterol
  
  Volume: 49(4) Issue: 4 Pages: 748-54
- DOI
  10.1007/s00535-013-0826-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590962, KAKENHI-PROJECT-24390184
[Journal Article] Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis.2014
- Author(s)
  Sato M, Kondo M, Tateishi R, Fujiwara N, Kato N, Yoshida H, Taguri M, Koike K
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 3 Pages: e91822-e91822
- DOI
  10.1371/journal.pone.0091822
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-24390184
[Journal Article] The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.2014
- Author(s)
  Shibata C, Ohno M, Otsuka M, Kishikawa T, Goto K, Muroyama R, Kato N, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  Virology
  
  Volume: 462-463 Pages: 42-48
- DOI
  10.1016/j.virol.2014.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390184, KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979
[Journal Article] Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA.2014
- Author(s)
  Ohno M, Otsuka M, Kishikawa T, Shibata C, Yoshikawa T, Takata A, Muroyama R, Kowatari N, Sato M, Kato N, Kuroda S, Koike K.
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 5581-5590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390184
[Journal Article] A genome-wide association study of HCV-induced liver cirrhosis in the Japanese populationidentifies novel susceptibility loci at the MHC region2013
- Author(s)
  Otsuka M
- Journal Title
  
  J Hepatol
  
  Volume: I(n press) Issue: 5 Pages: 875-882
- DOI
  10.1016/j.jhep.2012.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-23710316, KAKENHI-PROJECT-24390184
[Journal Article] Identification of a Functional Variant in the MICA Promoter Which Regulates MICA Expression and Increases HCV-Related Hepatocellular Carcinoma Risk.2013
- Author(s)
  Lo PH, Urabe Y, Kumar V, Tanikawa C, Koike K, Kato N, Miki D, Chayama K, Kubo M, Nakamura Y, Matsuda K.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 4 Pages: e61279-e61279
- DOI
  10.1371/journal.pone.0061279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710316, KAKENHI-PROJECT-24390184, KAKENHI-PUBLICLY-25134707, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-25710009
[Journal Article] The AMPK-Related Kinase SNARK Regulates Hepatitis C Virus Replication and Pathogenesis Through Enhancement of TGF-β Signaling2013
- Author(s)
  Goto K, Lin W, Zhang L, Jilg N, Shao RX, Schaefer EA, Zhao H, Fusco DN, Peng LF, Kato N, Chung R T.
- Journal Title
  
  Journal of Hepatology
  
  Volume: 59 Issue: 5 Pages: 942-948
- DOI
  10.1016/j.jhep.2013.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06190, KAKENHI-PROJECT-24390184
[Journal Article] Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2013
- Author(s)
  Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K.
- Journal Title
  
  Hepatol Res.
  
  Volume: : Issue: 10
- DOI
  10.1111/hepr.12258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590962, KAKENHI-PROJECT-24390184
[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.2011
- Author(s)
  Kumar V, Kato N, et al.
- Journal Title
  
  Nat Genet
  
  Volume: (in press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Direct differentiation of hepatic cells from human induced pluripotentstem cells using a limited number of cytokines.2011
- Author(s)
  Takata A, Kato N, et al.
- Journal Title
  
  Hepatol Int
  
  Volume: (in press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] MicroRNA122 is a key regulator of α-fetoprotein expression and biologically aggressive behavior of hepatocellular carcinoma.2011
- Author(s)
  Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K
- Journal Title
  
  Nat Commun 2
  
  Pages: 338-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.2011
- Author(s)
  Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K
- Journal Title
  
  Nat Genet 43
  
  Pages: 455-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Double-stranded-RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment.2010
- Author(s)
  Chang J-H, Kato N, et al.
- Journal Title
  
  Liver Int
  
  Volume: 30 Pages: 311-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Influence of anti-HBc seropositivity on the risk of hepatocellular carcinoma in HCV-infected patients after adjusting for confounding factors.2010
- Author(s)
  Ohki T, Tateishi R, Goto E, Sato T, Masuzaki R, Imamura J, Goto T, Kanai F, Kato N, Shiina S, Yoshida H, Kawabe T, Omata M
- Journal Title
  
  J Viral Hepat 17
  
  Pages: 91-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Influence of anti-HBc seropositivity on the risk of hepatocellular carci-noma in HCV-infected patients after adjusting for confounding factors.2010
- Author(s)
  Ohki T, Kato N, et al.
- Journal Title
  
  J Viral Hepato
  
  Volume: 17 Pages: 91-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Double-stranded-RNA-activated protein kinase inhibits hepatitis C virus replication but maybe not essential in interferon treatment.2010
- Author(s)
  Chang J-H, Kato N, et al.
- Journal Title
  
  Liver International 30
  
  Pages: 311-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Double-stranded-RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment.2010
- Author(s)
  Chang J-H, Kato N, Muroyama R, Taniguchi H, Guleng B, Dharel N, Shao R-X, Tateishi K, Jazag A, Kawabe T, Omata M
- Journal Title
  
  Liver Int 30
  
  Pages: 311-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.2009
- Author(s)
  Li C-Z, Kato N, Chang J-H, Muroyama R, Shao R-X, Dharel N, Sermsathanasawadi R, Kawabe T, Omata M
- Journal Title
  
  Liver Int 29
  
  Pages: 1413-1421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis C.2009
- Author(s)
  Sato T, Tateishi R, Yoshida H, Ohki T, Masuzaki R, Imamura J, Goto T, Kanai F, Obi S, Kato N, Shiina S, Kawabe T, Omata M
- Journal Title
  
  Hepatol Int 3
  
  Pages: 544-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma.2009
- Author(s)
  Hu Z, Kato N, et al.
- Journal Title
  
  Cancer Science 100
  
  Pages: 2465-2468
- NAID
  10027198911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.2009
- Author(s)
  Li CZ, Kato N, et al.
- Journal Title
  
  Liver International 29
  
  Pages: 1413-1421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma.2009
- Author(s)
  Hu Z, Muroyama R, Kowatari N, Chang J, Omata M, Kato N
- Journal Title
  
  Cancer Sci 100
  
  Pages: 2465-2468
- NAID
  10027198911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients ; An analysis based on gender differences.2009
- Author(s)
  Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato N, Shiina S, Omata M
- Journal Title
  
  Int J Cancer 125
  
  Pages: 2264-2269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography.2009
- Author(s)
  Masuzaki R, Tateishi R, Yoshida H, Yoshida H, Sato S, Kato N, Kanai F, Sugioka Y, Ikeda H, Shiina S, Kawabe T, Omata M
- Journal Title
  
  Hepatology 49
  
  Pages: 1954-1961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article]2009
- Author(s)
  Omata M, Kato N, et al.
- Journal Title
  
  Hepatocellular carcinoma"epidemics"in Japan. In : Hepatitis C virus.(International Medical Press Ltd.)
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Risk Assessment of hepatocellular carcinoma in chronic hepatitis C patients by transient elastography.2008
- Author(s)
  Masuzaki R, Tateishi R, Yoshida H, Yoshida H, Sato S, Kato N, Kanai F, Sugioka Y, Ikeda H, Shiina S, Kawabe T, Omata M
- Journal Title
  
  J Clin Gastroenterol 42
  
  Pages: 839-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus2008
- Author(s)
  Dharel N, Kato N, Muroyama R, Taniguchi H, Otsuka M, Wang Y, Jazag A, Shao R-X, Chang J-H, Adler MK, Kawabe T, Omata M.
- Journal Title
  
  Hepatology 47
  
  Pages: 1136-1149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Journal Article] Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients.2008
- Author(s)
  Ohki T, Tateishi R, Sato T, Masuzaki R, Imamura J, Goto T, Yamashiki N, Yoshida H, Kanai F, Kato N, Shiina S, Yoshida H, Kawabe T, Omata M
- Journal Title
  
  Clin Gastroenterol Hepatol 6
  
  Pages: 459-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus2008
- Author(s)
  Dharel N, Kato N, Muroyama R, Taniguchi H, Otsuka M, Wang Y, Jazag A, Shao RX, Chang JH, Adler MK, Kawabe T, Omata M
- Journal Title
  
  Hepatology 47
  
  Pages: 1136-1149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Association of interferon regulatory factor-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients.2008
- Author(s)
  Sermasathanasawadi R, Kato N, et. al.
- Journal Title
  
  Liver Int
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590718
[Journal Article] Potential contribution of tumor suppressor p53 in the host defense against hepatits C virus.2008
- Author(s)
  Dharel N, Kato N, et. al.
- Journal Title
  
  Hepatology 47
  
  Pages: 1136-1149
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590718
[Journal Article] Association of IRF-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients.2008
- Author(s)
  Sermasathanasawadi R, Kato N, Muroyama R, Dharel N, Shao R-X, Chang J-H, Li C-Z, Kawabe T, Omata M
- Journal Title
  
  Liver Int 28
  
  Pages: 798-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Association of interferon regulatory factor -7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients2008
- Author(s)
  Sermasathanasawadi R, Kato N, Muroyama R, Dharel N, Shao RX, Chang JH, Li CZ, Kawabe T, Omata M
- Journal Title
  
  Liver Int (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A2007
- Author(s)
  Moriyama M, Kato N, Otsuka M, Shao RX, Taniguchi H, Kawabe T, Omata M
- Journal Title
  
  Hepatol Int 1
  
  Pages: 302-310
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A.2007
- Author(s)
  Moriyama M, Kato N, et. al.
- Journal Title
  
  Hepatol Int 1
  
  Pages: 302-310
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590718
[Journal Article] Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A2007
- Author(s)
  Moriyama M, Kato N, Otsuka M, Shao R-X, Taniguchi H, Kawabe T, Omata M.
- Journal Title
  
  Hep Intl 1
  
  Pages: 302-310
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Journal Article] Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response2006
- Author(s)
  Wang Y, Kato N, Jazag A, Dharel N, Otsuka M, Taniguchi H, Kawabe T, Omata M
- Journal Title
  
  Gastroenterology 130
  
  Pages: 883-892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] for Tokyo Hepatitis Network. Twenty-four weeks of interferon alpha-2b in combination with ribavirin for Japanese hepatitis C patients : sufficient treatment period for patients with genotype 2 but not for patients with genotype 12006
- Author(s)
  Fujiwara K, Yokosuka O, Komine F, Moriyama M, Kato N, Yoshida H, Tanaka N, Imazeki F, Shiratori Y, Arakawa Y, Omata M
- Journal Title
  
  Liver Int 26
  
  Pages: 520-528
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response.2006
- Author(s)
  Wang Y, Kato N, Amarsanaa J, Dharel N, Otsuka M, Taniguchi H, Kawabe T, Omata M.
- Journal Title
  
  Gastroenterology 130
  
  Pages: 883-892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis2006
- Author(s)
  Dharel N, Kato N, Muroyama R, Moriyama M, Shao RX, Kawabe T, Omata M
- Journal Title
  
  Clin Cancer Res 12
  
  Pages: 4867-4871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Hepatitis C Virus Core Protein and Hepatitis Activity Are Associated through Transactivation of Interleukin-82005
- Author(s)
  Hoshida Y, Kato N, Yoshida H, Wang Y, Tanaka M, Goto T, Otsuka M, Taniguchi H, Moriyama M, Imazeki F, Yokosuka O, Kawabe T, Shiratori Y, Omata M
- Journal Title
  
  J Infect Dis 192
  
  Pages: 266-275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C.2005
- Author(s)
  Kato N et al.
- Journal Title
  
  Hepatology 42
  
  Pages: 846-853
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.2005
- Author(s)
  Otsuka M, Kato N, Moriyama M, Taniguchi H, Wang Y, Narayan D, Kawabe T, Omata M.
- Journal Title
  
  Hepatology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307019
[Journal Article] Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses2005
- Author(s)
  Otsuka M, Kato N, Moriyama M, Taniguchi H, Wang Y, Dharel N, Kawabe T, Omata M
- Journal Title
  
  Hepatology 41
  
  Pages: 1004-1012
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways.2005
- Author(s)
  Shao RX, Otsuka M, Kato N, Taniguchi H, Hoshida Y, Moriyama M, Kawabe T, Omata M.
- Journal Title
  
  Gastroenterology 128(1)
  
  Pages: 86-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways.2005
- Author(s)
  Shao R-X, Otsuka M, Kato N, Taniguchi H, Hoshida Y, Moriyama M, Kawabe T, Omata M.
- Journal Title
  
  Gastroenterology 128
  
  Pages: 86-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Hepatitis C virus core protein and hepatitis activity are associated through transactivation of interleukin-8.2005
- Author(s)
  Hoshida Y, Kato N, Yoshida H, Wang Y, Tanaka M, Goto T, Otsuka M, Taniguchi H, Moriyama M, Imazeki F, Yokosuka O, Kawabe T, Shiratori Y, Omata M.
- Journal Title
  
  J Infect Dis 192
  
  Pages: 266-275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients2005
- Author(s)
  Shao R-X, Hoshida Y, Otsuka M, Kato N, Tateishi R, Teratani T, Shiina S, Taniguchi H, Moriyama M, Kawabe T, Omata M
- Journal Title
  
  World J Gastroenterol 11
  
  Pages: 1995-1999
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] No mutations in the tyrosine kinases of human hepatic, pancreatic, and gastric cancer cell lines2005
- Author(s)
  Shao RX, Otsuka M, Kato N, Chang JH, Muroyama R, Taniguchi H, Moriyama M, Wang Y, Kawabe T, Omata M
- Journal Title
  
  J Gastroenterol 40
  
  Pages: 918-918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Journal Article] Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C.2005
- Author(s)
  Kato N, Ji G, Wang Y, Baba M, Hoshida Y, Otsuka M, Taniguchi H, Moriyama M, Dharel N, Goto T, Shao R-X, Matsuura T, Ishii K, Shiina S, Kawabe T, Muramatsu M, Omata M.
- Journal Title
  
  Hepatology 42
  
  Pages: 846-853
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in Japanese patients with hepatitis C virus infection.2004
- Author(s)
  Wang Y, Kato N, Hoshida Y, Otsuka M, Taniguchi H, Moriyama M, Shiina S, Kawabe T, Ito YM, Omata M.
- Journal Title
  
  Clin Cancer Res 10
  
  Pages: 2441-2446
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription.2004
- Author(s)
  Taniguchi H, Kato N, Otsuka M, Goto T, Yoshida H, Shiratori Y, Omata M.
- Journal Title
  
  J Med Virol 72
  
  Pages: 52-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307019
[Journal Article] Hepatitis C virus core protein upregulates transforming growth factor-β1 transcription.2004
- Author(s)
  Taniguchi H, Kato N, Otsuka M, Goto T, Yoshida H, Shiratori Y, Omata M.
- Journal Title
  
  J Med Virol 72
  
  Pages: 52-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Genes associated with human hepatocellular carcinoma cell chemosensitivity to 5-fluorouracil plus interferon-α combination chemotherapy.2004
- Author(s)
  Moriyama M, Hoshida Y, Kato N, Otsuka M, Yoshida H, Kawabe T, Omata M.
- Journal Title
  
  Int J Oncol 25
  
  Pages: 1279-1287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570447
[Journal Article] Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation.2004
- Author(s)
  Otsuka M, Kato N, Shao RX, Hoshida Y, Ijichi H, Koike Y, Taniguchi H, Moriyama M, Shiratori Y, Kawabe T, Omata M.
- Journal Title
  
  Hepatology 40(1)
  
  Pages: 243-251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Vitamin K2 inhibits the growth and invasiveness of hepatocellular Carcinoma cells via protein kinase A activation.2004
- Author(s)
  Otsuka M, Kato N, Shao RX, Hoshida Y, Ijichi H, Koike Y, Taniguchi H, Moriyama M, Shiratori Y, Kawabe T, Omata M.
- Journal Title
  
  Hepatology 40(1)
  
  Pages: 243-251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-x(L) expression.2002
- Author(s)
  Otsuka M, Kato N, Taniguchi H, Yoshida H, Goto T, Shiratori Y, Omata M.
- Journal Title
  
  Virology 296
  
  Pages: 84-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307019
[Journal Article] HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.2002
- Author(s)
  Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD.
- Journal Title
  
  Oncogene 21
  
  Pages: 4801-4811
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307019
[Journal Article] Hepatitis C virus core protein activates nuclear factor κB-dependent signaling through tumor necrosis factor receptor-associated factor.2001
- Author(s)
  Yoshida H, Kato N, Shiratori Y, Otsuka M, Maeda S, Kato J, Omata M.
- Journal Title
  
  J Biol Chem 276
  
  Pages: 16399-16405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307019
[Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines.
- Author(s)
  Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K
- Journal Title
  
  Hepatol Int (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Vitamin K2 binds 17b-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism
- Author(s)
  Otsuka M, Kato N, Ichimura T, Abe S, Tanaka Y, Taniguchi H, Hoshida Y, Moriyama M, Wang Y, Shao R-X, Narayan D, Muroyama R, Kanai F, Kawabe T, Isobe T, Omata M.
- Journal Title
  
  Life Sciences (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Association of IRF-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients
- Author(s)
  Sermasathanasawadi R, Kato N, Muroyama R, Dharel N, Shao R-X, Chang J-H, Li C-Z, Kawabe T, Omata M.
- Journal Title
  
  Liver Int (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Journal Article] Vitamin K2 binds 17b-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism
- Author(s)
  Otsuka M, Kato N, Ichimaru T, Abe S, Tanaka Y, Taniguchi H, Hoshida Y, Moriyama M, Wang Y, Shao R-X, Narayan D, Muroyama R, Kanai F, Kawabe T, Isobe T, Omata M.
- Journal Title
  
  Life Sciences (印刷中)
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Vitamin K2 binds 17b-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism
- Author(s)
  Otsuka M, Kato N, Ichimura T, Abe S, Tanaka Y, Taniguchi H, Hoshida Y, Moriyama M, Wang Y, Shao R-X, Narayan D, Muroyama R, Kanai F, Kawabe T, Isobe T, Omata M.
- Journal Title
  
  Life Sciences (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Presentation] The role of Hepatitis B Virus Inergration in Hepatocarcinogenesis.2024
- Author(s)
  Kato N.
- Organizer
  APASL
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] A Prospective Study to Assess the Safety and Efficacy of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma Aiming to Maximise Its Potential in Current Clinical Practice2023
- Author(s)
  Kobayashi K, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] A Randomized Phase II Trial to Assess Safety and Efficacy of Regorafenib in Patients with Advanced Hepatocellular Carcinoma who were not Included in the RESORCE Trial: REGAIN Trial2023
- Author(s)
  Koroki K, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] A Prospective Study to Assess the Safety and Efficacy of Ramucirumab in Advanced Hepatocellular Carcinoma Patients in Japanese Real-world Practice: R-evolution Study2023
- Author(s)
  Kobayashi K, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] Differentiation of AST/ALT Elevation during Immunotherapy in Patients with Advanced Hepatocellular Carcinoma and Other Cancers2023
- Author(s)
  Izai R, Ogasawara S, Kato N, et al.
- Organizer
  APASL Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27577
[Presentation] レチノイドによるがん微小環境を標的とした肝がん治療戦略2021
- Author(s)
  音山裕美, 荒井潤, 後藤覚, 中島陽子, 杉浦育也, 梶原敦, 市川雪, 魚住祥二郎, 下間祐, 打越学, 坂木理, 中川良, 室山良介, 加藤直也, 吉田仁
- Organizer
  JDDW 2021
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] ロイコトリエン拮抗薬による膜型MICA発現増強を介した肝癌治療戦略2021
- Author(s)
  荒井潤, 加藤直也, 吉田仁.
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] 肝がんにおける免疫療法について2021
- Author(s)
  加藤直也
- Organizer
  第23回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] Screening of ADAM9 inhibitors for suppression of soluble MICA in hepatocellular carcinoma2021
- Author(s)
  Ogawa K, Nakagawa R, Ishino T, Iwanaga T, Unozawa H, Fujiwara K, Nakagawa M, Sakuma T, Fujita N, Kanzaki H, Koroki K, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Ogasawara S, Muroyama R, Nakamoto S, Chiba T, Kato N
- Organizer
  AASLD 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] Novel immuno-oncotherapy against HCC by targeting MICA2021
- Author(s)
  Otoyama Y, Arai J, Goto K, Nakagawa R, Muroyama R, Sugiura I, Nakajima Y, Kajiwara A, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Kato N, Yoshida H
- Organizer
  APASL oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] Regorafenib and its metabolotes could Induce NK cell-mediated cytotoxixity in HCC by targeting ADAM92021
- Author(s)
  Arai J, Otoyama Y, Goto K, Nakagawa R, Muroyama R, Ogawa K, Sugiura I, Nakajima Y, Kajiwara A, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Kato N, Yohida H
- Organizer
  APASL oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] 大腸癌に対するレゴラフェニブ治療においてMICAは加療効果予測のバイオマーカーになり得る2021
- Author(s)
  荒井潤, 後藤覚, 音山裕美, 杉浦育也, 中島陽子, 梶原敦, 市川雪, 魚住祥二郎, 下間祐, 打越学, 坂木理, 中川良, 室山良介, 加藤直也, 吉田仁
- Organizer
  JDDW 2021
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] Development of novel therapeutic agents for HCC by suppressing soluble MICA through ADAM9 inhibition2021
- Author(s)
  Ogawa K, Nakagawa R, Ao J, Qiamg N, Ma Y, Zhang J, Iwanaga T, Sakuma T, Kanzaki H, Kobayashi K, Nakamura M, Kanogawa N, Kondo T, Ogasawara S, Muroyama R, Nakamoto S, Chiba T, Kanda T, Maruyama H, Kato N
- Organizer
  APASL oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] 内科医が知っておくべき肝臓病の最新情報2020
- Author(s)
  加藤直也
- Organizer
  令和2年度千葉県内科医会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] パラダイムシフトを迎える肝癌薬物治療ースチバーガの治療意義ー2020
- Author(s)
  加藤直也
- Organizer
  第56回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] Withコロナ時代に目指すべきC型肝硬変治療2020
- Author(s)
  加藤直也
- Organizer
  第56回日本肝臓学会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] C型肝炎のアンメット・メディカルニーズに挑む2020
- Author(s)
  加藤直也
- Organizer
  第28回日本消化器病関連学会週間（JDDW2020）
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] C型肝炎の残された課題～急性肝不全を含めて～2020
- Author(s)
  加藤直也
- Organizer
  第46回日本急性肝不全研究会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] 生存期間延長を目指した進行肝癌治療戦略2020
- Author(s)
  加藤直也
- Organizer
  第22回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] 肝癌のHot Topics2020
- Author(s)
  加藤直也
- Organizer
  第106回消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] HCC:View in Host Genetics2019
- Author(s)
  Naoya Kato
- Organizer
  Achievement and New Challenge of LiverDiseases 2019 Kaohsiung Liver Forum
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] HCV-associated HCC-Basics and clinics2019
- Author(s)
  Naoya Kato
- Organizer
  HEPATITIS CLNICAL FPRUM
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] ロイコトリエン拮抗薬によるADAM9制御を介した肝癌自然免疫療法の開発2019
- Author(s)
  荒井潤、吉田仁、加藤直也
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] 肝細胞癌に対する分子標的療法がGWAS感受性遺伝子MICAに与える影響の検討2019
- Author(s)
  荒井潤、吉田仁、加藤直也
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] B型肝炎と肝がん治療のアンメット・ニーズに挑む2019
- Author(s)
  加藤直也
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03633
[Presentation] GWASにより見出された肝癌関連遺伝子MICAの発現増強による新たな肝発癌抑止法の開発．2014
- Author(s)
  加藤直也、後藤　覚、室山良介、中川　良、李　ウェンウェン、伊藤彩弥香、松原康朗．
- Organizer
  第10回広島肝臓プロジェクト研究センターシンポジウム
- Place of Presentation
  広島
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] 肝発癌において自然免疫関連分子MICAはB型肝炎とC型肝炎では反対の役目を担っている．2013
- Author(s)
  加藤直也、室山良介、小池和彦．
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] MICA plays an opposite role in hepatocarcinogenesis between hepatitis B and hepatitis C.2013
- Author(s)
  Naoya Kato, Vinod Kumar, Ryosuke Muroyama, Ryosuke Tateishi, Yasuhito Tanaka, Masashi Mizokami, Masao Omata, Kazuhiko Koike, Koichi Matsuda.
- Organizer
  48th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] Effective inducers of a GWAS-discovered anti-HCC gene MICA.2013
- Author(s)
  Kaku Goto, Ryosuke Muroyama, Wenwen Li, Norie Kowatari, Ryo Nakagawa, Naoya Kato.
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] An HCV-HCC susceptibility gene MICA found in GWAS was effectively induced by HDAC inhibitors.2013
- Author(s)
  Kaku Goto, Ryosuke Muroyama, Wenwen Li, Norie Kowatari, Ryo Nakagawa, Naoya Kato.
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Washington, DC, U.S.A.
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] GWAS により同定された肝癌感受性遺伝子MICA の発現を誘導する薬剤の探索．2013
- Author(s)
  後藤　覚、室山良介、李　雯雯、中川　良、古渡礼恵、加藤直也．
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] MICA might have opposite effect on hepatocarcinogenesis between B-HCC and C-HCC.2013
- Author(s)
  Ryosuke Muroyama, Vinod Kumar, Kaku Goto, Norie Kowatari, Wenwen Li, Ryo Nakagawa, Ryosuke Tateishi, Yasuhito Tanaka, Masashi Mizokami, Masao Omata, Kazuhiko Koike, Koichi Matsuda, Naoya Kato.
- Organizer
  2013 International Meeting on Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] ゲノムワイド関連解析によるC型肝硬変/肝癌の感受性遺伝子の同定．2013
- Author(s)
  室山良介、松田浩一、加藤直也．
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] HDAC inhibitors are potent suppressors of HCV-induced hepatocarcinogenesis by upregulating MICA a GWAS-identified HCC susceptibility gene.2012
- Author(s)
  Goto K, Kato N, et al.
- Organizer
  The 63th Annual Meeting of the American Assoclation for the Study of Liver Diseases
- Place of Presentation
  Boston, USA
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] C型肝癌感受性遺伝子MICAを誘導する薬剤の探索2012
- Author(s)
  後藤覚、加藤直也, ほか
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  ポルテ金沢(金沢市)
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] Exploration for inducers of MICA, a GWAS-identif ied genetic susceptibility factor for HCV-induced HCC.2012
- Author(s)
  Goto K, Kato N, et al.
- Organizer
  19th Internatlonal Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Venice, Italy
- Year and Date
  2012-10-06
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] C型肝癌感受性を決定する遺伝子MICAを誘導する薬剤による肝発癌抑止法の開発2012
- Author(s)
  後藤覚、加藤直也, ほか
- Organizer
  第16回肝臓学会大会
- Place of Presentation
  神戸国際展示場(神戸市)
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] A genome-wide study identifies susceptibility loci for hepatitis C virus induced hepatocellular carcinoma.2011
- Author(s)
  Kato N, Kumar V, Muroyama R, Kowatari N, Li W, Otsuka M, Tateishi R, Yoshida H, Omata M, Koike K, Nakamura Y, Matsuda K
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver.
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Core mutant ratio is associated with response to PEG-IFN/RBV treatment in HCV genotype 1b patients.2011
- Author(s)
  Li W, Muroyama R, Hu Z, Kowatari N, Goto T, Yoshida H, Li Q, Omata M, Koike K, Kato N
- Organizer
  The 21st Conference of the Asian Pacific Association for the Study of the Liver.
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Core mutant ratio is associated with response to PEG-IFN/RBV treatment in HCV genotype 1b patients.2011
- Author(s)
  Li W, Kato N, et al.
- Organizer
  The 21st Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] A genome-wide study identifies susceptibility loci for hepatitis C virus-induced hepatocellular carcinoma.2011
- Author(s)
  Kato N, et al.
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Mutant ratio of amino acid 70 in genotype lb HCV core protein is associated with response to PEG-IFN/RBV treatment.2010
- Author(s)
  Li W, Kato N, et al.
- Organizer
  The APASL 7th Single Topic Conference "Hepatitis C Virus"
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Quantification of hepatitis C virus genotype 1b codon 70 wild and mutant types and their response to PEG-IFN/RBV treatment.2010
- Author(s)
  Kato N.
- Organizer
  BIT's 1st World Congress of Virus and Infections-2010
- Place of Presentation
  Busan, Republic of Korea
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Quantification of hepatitis C virus genotype 1b codon 70 wild and mutant types and their response to PEG-IFN/RBV treatment.2010
- Author(s)
  加藤直也
- Organizer
  BIT's 1st World Congress of Virus and Infections 2010.
- Place of Presentation
  Busan, Republic of Korea
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Mutant ratio of amino acid 70 in genotype 1b HCV core protein is associated with response to PEG-IFN/RBV treatment.2010
- Author(s)
  Li W, Kato N
- Organizer
  The APASL 7th Single Topic Conference "Hepatitis C Virus"
- Place of Presentation
  Chiba, Japan
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Amino acid substitutions in genotype 1b HCV core protein and response to PEG-IFN/RBV treatment.2010
- Author(s)
  Li W, Kato N, et al.
- Organizer
  17th International Meeting on Hepatitis C Virus and Related Viruses
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Amino acid substitutions at position 70 of HCV genotype 1b core region is related to the increased HCC risk and non-virological response to PEG-IFN plus RBV combination therapy.2009
- Author(s)
  Kato N, Hu Z, Muroyama R, Goto T, Kowatari N, Chang J, Omata M
- Organizer
  16th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Amino acid substitutions at position 70 of HCV genotype 1b core region is related to the increased HCC risk and non-virological response to PEG-IFN plus RBV combination therapy.2009
- Author(s)
  Kato N, et al.
- Organizer
  16^<th> International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] C型肝炎ウイルス増殖と病態を規定するインターフェロン関連分子とその多型2008
- Author(s)
  加藤直也、常金海、小俣政男
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Suitable interferon treatment phase using acute hepatitis C cell culture model2007
- Author(s)
  Meng S-X, Kato N, Shao R-X, Muroyama R, Chang J-H, Kawabe T, Omata M.
- Organizer
  The 58th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] Determining suitable interferon treatment phase using acute hepatitis C cell culture model2007
- Author(s)
  Meng SX, Kato N, Shao RX, Muroyama R, Chang JH, Kawabe T, Omata M
- Organizer
  5th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes Convention Cente
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Presentation] Both PKR and MxA inhibit replication of hepatitis C virus2007
- Author(s)
  Chang J-H, Kato N, Muroyama R, Meng S-X, Kawabe T, Omata M
- Organizer
  14th International Syposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Glasgow Royal Concert Hall
- Year and Date
  2007-09-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Presentation] Both PKR and MixA inhibit replication of hepatitis C virus.2007
- Author(s)
  Kato N, et. al.
- Organizer
  14th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Glasgow, CK
- Year and Date
  2007-09-13
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] Hepatitis C virus NS5A binding to nucleosome assembly protein 1(Nap 1) accelerated HCV replication2007
- Author(s)
  Shao R-X, Kato N, Otsuka M, Yamada N, Chang J-H, Muroyama R, Kawabe T, Omata M.
- Organizer
  The 58th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] Both PKR and MxA inhibit replication of hepatitis C virus2007
- Author(s)
  Chang J-H, Kato N, Muroyama R, Meng S-X, Kawabe T, Omata M.
- Organizer
  14th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Glasgow, UK
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] IRF-7 gene polymorphisms are associated with liver cirrhosis in chronic hepatitis C patients2007
- Author(s)
  Sermsathanasawadi R, Kato N, Muroyama R, Shao RX, Chang JH, Li CZ, Kawabe T, Omata M
- Organizer
  43th Annual Meeting of the Japan Society of Hepatology
- Place of Presentation
  Hotel Grandpacific Meridien
- Year and Date
  2007-06-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Presentation] C型肝炎における病態と宿主遺伝子多様性の関連についての解析2006
- Author(s)
  加藤直也
- Organizer
  第36回日本肝臓学会東部会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2006-12-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Presentation] Inhibition of hepatitis C virus replication by tumor suppressor p53 : Novel prospects of p53 in the antiviral defense2006
- Author(s)
  Dharel N, Kato N, Taniguchi H, Otsuka M, Moriyama M, Muroyama R, Tateishi K, Jazag A, Shao R-X, Chang J-H, Kawabe T, Omata M.
- Organizer
  12th International Symposium on Viral Hepatitis and Liver Disease
- Place of Presentation
  Paris, France
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] Tumor suppressor p53 interacts with interferon regulatory factor 9 and regulates hepatitis C virus replication through transcriptional induction of interferon-stimulated genes2006
- Author(s)
  Dharel N, Kato N, Taniguchi H, Otsuka M,Moriyama M, Muroyama R, Tateishi K, Wang Y, Jazag A, Shao R-X, Chang J-H, Kawabe T, Omata M.
- Organizer
  The 57th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] Inhibition of hepatitis C virus replication by PKR2006
- Author(s)
  Chang J-H, Kato N, Taniguchi H, Guleng B, Tateishi K, Amarsanaa J, Dharel N, Moriyama M, Muroyama R, Shao R-X, Kawabe T, Omata M.
- Organizer
  12th International Symposium on Viral Hepatitis and Liver Desease
- Place of Presentation
  Paris, France
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590718
[Presentation] Toll-1ikeレセプター3のC6300T(Leu412Phe)多型はC型肝炎における炎症・線維化と関連する2006
- Author(s)
  加藤直也
- Organizer
  DDW-Japan 2006
- Place of Presentation
  道立総合体育センター
- Year and Date
  2006-10-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Presentation] C型肝炎における肝発癌関連SNPの網羅的探索2005
- Author(s)
  加藤直也
- Organizer
  第28回分子生物学会年会
- Place of Presentation
  福岡SRPセンタービル
- Year and Date
  2005-12-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209026
[Presentation] NK cell anti-tumor activity was boosted by SAHA identified to induce the expression of a GWAS-discovered HCV-HCC susceptibility gene MICA.
- Author(s)
  Goto K, Muroyama R, Li W, Nakagawa R, Matsubara Y, Kato N.
- Organizer
  The Liver Meeting 2014
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] Potentiated anti-tumor activity of NK cells by an approved drug identified to induce the expression of a GWAS-discovered HCV-HCC susceptibility gene MICA.
- Author(s)
  Goto K, Muroyama R, Li W, Nakagawa R, Matsubara Y, Kato N.
- Organizer
  21st International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Banff, Canada.
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] HBV induces an HBV-insuced HCC associated gene MICA through transcriptional activation in SNPS dependent manner.
- Author(s)
  Muroyama R, Goto K, Li W, Matsubara Y, Nakagawa R, Ito S, Kato N.
- Organizer
  2014 International Meeting on Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Los Angeles, USA
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] C型肝癌に対するラジオ波焼灼術後の再発, 予後に対するMICA, DEPDC5, IL28B, PNPLA3遺伝子多型の意義の検討．
- Author(s)
  佐藤雅哉、加藤直也、小池和彦．
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] GWASにより同定された肝癌感受性遺伝子MICAの発現制御を介した肝発癌抑止戦略．
- Author(s)
  後藤　覚、室山良介、加藤直也．
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] 腫瘍自然免疫を司るMICAのB型およびC型肝癌における役割．
- Author(s)
  室山良介、後藤　覚、松田浩一、田中靖人、茶山一彰、溝上雅史、小俣政男、小池和彦、加藤直也．
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] IL28B SNPがC型慢性肝炎患者における肝線維化・炎症・脂肪化に与える影響-メタアナリシスによる検討．
- Author(s)
  佐藤雅哉、近藤真由子、建石良介、加藤直也、吉田晴彦、小池和彦．
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] GWAS肝癌感受性遺伝子MICAを介した腫瘍免疫監視．
- Author(s)
  後藤　覚、加藤直也.
- Organizer
  第3回肝炎ウイルス研修会
- Place of Presentation
  東京
- Year and Date
  2015-02-26 – 2015-02-27
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] Impact of IL28B genetic variation on HCV-induced liver fibrosis, inflammation, and steatosis: a meta-analysis.
- Author(s)
  Sato M, Kondo M, Tateishi R, Kato N, Yoshida H, Koike K.
- Organizer
  49th annual meeting of the European Association for the Study of the Liver
- Place of Presentation
  London, United Kingdom
- Year and Date
  2014-04-09 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-24390184
[Presentation] B型肝癌感受性遺伝子MICAの発現制御による肝発癌抑止戦略．
- Author(s)
  加藤直也、後藤　覚、室山良介．
- Organizer
  第18回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24390184

1. KANAI Fumihiko (70334399)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. OMATA Masao (90125914)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
3. SHIINA Shuichirou (70251238)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. YOSHI Haruhiko (60240305)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. MUROYAMA Ryosuke (50549459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
6. SHIRATORI Yasushi (70196624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAWAKAMI Takayuki (60376457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OTSUKA Motoyuki

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
9. TADA Minoru (80302719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TERATANI Takuma (30359616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TATEISHI Keisuke (20396948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. MAEDA Shin (40415956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 丹羽泰郎 (20282668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小笠原定久 (20749155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
15. MATSUMURA Masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TANIGUCHI Hiroyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. TANAKA Yasuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 後藤覚

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
19. MATSUDA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. TANIKAWA Chizu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 千葉哲博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 金山健剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kato Naoya 加藤 直也

KATO NAOYA 加藤 直也

KATO Naoya 加藤 直也

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Development of all-round combined immunotherapy for advanced hepatocellular carcinomaPrincipal Investigator

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Comprehensive Management of Hepatocellular Carcinoma Targeting Innate Immunological Escape of the CancerPrincipal Investigator

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Functional analysis of MICA in hepatitis C virus-induced hepatocellular carcinoma and its therapeutic applicationPrincipal Investigator

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Interferon stimulated genes and its polymorphisms determining Hepatitis C virus replication and pathogenesis of hepatitis CPrincipal Investigator

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Comprehensive analysis of hepatitis Cvirus protein that disturb host interferon systemPrincipal Investigator

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Analyses of the individual risk for hepatocellular carcinoma by large scale search of single nucleotide polymorphisms of cytokine genesPrincipal Investigator

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B型肝炎ウイルスの逆転写酵素阻害剤耐性の分子基盤とその制御Principal Investigator

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Viral mutations and host diversities that contribute to hepatocarcinogenesisPrincipal Investigator

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Kato Naoya 加藤直也

KATO NAOYA 加藤直也

KATO Naoya 加藤直也