Uesawa Yoshihiro 植沢芳広

… Alternative Names

UESAWA Yoshihiro 植沢芳広

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Researcher Number	90322528
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 明治薬科大学, 薬学部, 教授 2013 – 2017: 明治薬科大学, 薬学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 57060:Surgical dentistry-related / Basic Section 57010:Oral biological science-related / Pathobiological dentistry/Dental radiology / Medical pharmacy
Keywords	Principal Investigator 化学構造 / 人工知能 / 機械学習 / 定量的構造活性相関 / 副作用データベース / ストレス応答パスウェイ / 核内受容体 / QSAR解析 / 医薬品副作用データベース / 重症皮膚副作用 … More / 中毒性表皮壊死融解症 / スティーヴンス・ジョンソン症候群 / ランダムフォレスト / ニューラルネットワーク / 副作用 / 緩和医療 / データベース / 構造活性相関 / オピオイド … More Except Principal Investigator クロモン誘導体 / 機械学習 / ハイパーサーミア / 細胞コロニー / 腫瘍細胞 / 深層学習 / 細胞画像 / 異常細胞 / 培養細胞 / 選択毒性 / QSAR / 口腔扁平上皮癌細胞 / 腫瘍選択性 / ニューラルネットワーク / ３次元培養 / スフェロイド / 人工知能 / 非接着性培養 / Geranylgeraniol / ハイパーサミア / マイルドハイパーサーミア / 併用療法 / 腫瘍選択性磁性体 / 低侵襲性治療 / 癌細胞特異的指向性酸化鉄微粒子 / 口腔癌 / 交流磁場 / 近赤外線 / 磁性酸化鉄ナノ粒子 / ICG / 新規癌指向性磁性酸化鉄ナノ粒子 / 細胞透過性ペプチド / シグナル伝達 / 口腔扁平上皮癌 / 細胞死 / 代謝物変化 / 遺伝子発現 / 作用点 / クロモン誘導体の標識 / 細胞への取り込み / ヒト口腔扁平上皮がん細胞 / 細胞死のタイプ / パスウェイ解析 / キナーゼ阻害活性 / 抗炎症効果 / 構造活性相関 / 相乗効果 / 3-クロモン誘導体 / エストロゲン関連受容体 / 神経毒性 / ケラチノサイト毒性 / 口腔扁平上皮がん細胞 / 画像解析 / AI / 正常細胞 / 細胞組織加工製品 / バリデーション / 細胞分化 / 幹細胞 / 医薬品安全性 / 再生医療 / 副作用の緩和 / 作用機序 / 有機合成 / ヒト口腔扁平上皮癌 / 3-スチリルクロモン類 / 化学記述子 / 置換基 / オーロン / ピペリン酸エステル / スチリルクロモン / subG1 / アポトーシス誘導能 / 3次元構造 / QSAR解析 / カスパーゼ-3 / 細胞周期 / 分子軌道解析 / アポトーシス / クロモン環 / コンパニオンドラッグ / 鎮痛効果 / トランスポーター / 血液脳関門 / 定量的構造活性相関 / 併用薬 / モルヒネ Less

リアルワールドデータに基づく重症皮膚副作用発症機序の解明と予測法の開発Principal Investigator
- Principal Investigator
  
  植沢芳広
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Search for characteristic markers of stem cell and cell validation by prediction of cell characteristics using AI
- Principal Investigator
  
  佐藤光利
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Elucidation of selective cytotoxicity against malignant cells by chromone derivatives
- Principal Investigator
  
  Sakagami Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Meikai University
Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles
- Principal Investigator
  
  Tohnai Iwai
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Search for characteristic markers of stem cells for use in cell therapeutics and improvement of validation accuracy by AI
- Principal Investigator
  
  SATOH Mitsutoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer
- Principal Investigator
  
  Sakagami Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Adverse Reactions to Potent Opioids: An analysis using the largescale Japanese Adverse Drug Event Report databasePrincipal Investigator
- Principal Investigator
  
  Uesawa Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Meiji Pharmaceutical University
A study on concomitant drugs to improve the analgesic effects and decrease the side effects of morphine
- Principal Investigator
  
  Kagaya Hajime
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Meiji Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] ケモインフォマティクスにおけるデータ収集の最適化と解析手法2023
- Author(s)
  黒﨑宏太、植沢芳広
- Total Pages
  13
- Publisher
  技術情報協会
- ISBN
  9784861049446
- Data Source
  KAKENHI-PROJECT-22K06707
[Book] in silico創薬におけるスクリーニングの高速化・高精度化技術2018
- Author(s)
  植沢芳広ら
- Total Pages
  540
- Publisher
  (株)技術情報協会
- ISBN
  9784861046889
- Data Source
  KAKENHI-PROJECT-15K08111
[Book] In Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs2017
- Author(s)
  Uesawa Y, et al.
- Total Pages
  104
- Publisher
  Frontiers in Environmental Science
- ISBN
  9782889451975
- Data Source
  KAKENHI-PROJECT-15K08111
[Book] 緩和医療薬学-SCIENCEとARTの融合と実践-2016
- Author(s)
  加賀谷肇、植沢芳広、野澤玲子
- Total Pages
  192
- Publisher
  京都廣川
- Data Source
  KAKENHI-PROJECT-15K08111
[Book] 緩和医療薬学-SCIENCEとARTの融合と実践-2016
- Author(s)
  加賀谷肇、植沢芳広、野澤玲子
- Total Pages
  192
- Publisher
  京都廣川(2016)
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] The Association between Molecular Initiating Events and Drug-Induced Hiccups2024
- Author(s)
  Hosoya Ryuichiro、Ishii-Nozawa Reiko、Terajima Tomoko、Kagaya Hajime、Uesawa Yoshihiro
- Journal Title
  
  Pharmaceuticals
  
  Volume: 17 Issue: 3 Pages: 379-379
- DOI
  10.3390/ph17030379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06707
[Journal Article] Analysis of Opioid-Related Adverse Events in Japan Using FAERS Database2023
- Author(s)
  Hirai Risako、Uesawa Yoshihiro
- Journal Title
  
  Pharmaceuticals
  
  Volume: 16 Issue: 11 Pages: 1541-1541
- DOI
  10.3390/ph16111541
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06707
[Journal Article] Comprehensive Study of Drug-Induced Pruritus Based on Adverse Drug Reaction Report Database2023
- Author(s)
  Nakao Yuriko、Asada Mizuho、Uesawa Yoshihiro
- Journal Title
  
  Pharmaceuticals
  
  Volume: 16 Issue: 10 Pages: 1500-1500
- DOI
  10.3390/ph16101500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06707
[Journal Article] Potentiation of anticancer activity of G<sub>2</sub>/M blockers by mild hyperthermia2023
- Author(s)
  Tagawa Y, SAKAGAMI H, TANUMA S, AMANO S, UOTA S, BANDOW K, TOMOMURA M, UESAWA Y, TAKAO K, SUGITA Y, YAMAMOTO N, SAKASHITA H, NAKAKAJI R, KOIZUMI T, MITSUDO K, TOHNAI I
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 8 Pages: 3429-3439
- DOI
  10.21873/anticanres.16518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03893
[Journal Article] Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity2022
- Author(s)
  Chhikara Aruna、Roayapalley Praveen K.、Sakagami Hiroshi、Amano Shigeru、Satoh Keitaro、Uesawa Yoshihiro、Das Umashankar、Das Swagatika、Borrego Edgar A.、Guerena Cristina D.、Hernandez Clare R.、Aguilera Renato J.、Dimmock Jonathan R.
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 19 Pages: 6718-6718
- DOI
  10.3390/molecules27196718
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Investigation of carbonic anhydrase inhibitory effects and cytotoxicities of pyrazole-based hybrids carrying hydrazone and zinc-binding benzenesulfonamide pharmacophores2022
- Author(s)
  Yamali Cem、Sakagami Hiroshi、Satoh Keitaro、Bandow Kenjiro、Uesawa Yoshihiro、Bua Silvia、Angeli Andrea、Supuran Claudiu T.、Gul Halise Inci
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 127 Pages: 105969-105969
- DOI
  10.1016/j.bioorg.2022.105969
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives2022
- Author(s)
  Naitoh Kotone、Orihara Yuta、Sakagami Hiroshi、Miura Takumi、Satoh Keitaro、Amano Shigeru、Bandow Kenjiro、Iijima Yosuke、Kurosaki Kota、Uesawa Yoshihiro、Hashimoto Masashi、Wakabayashi Hidetsugu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 5 Pages: 2601-2601
- DOI
  10.3390/ijms23052601
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid2022
- Author(s)
  MATSUDA REONA、SAKAGAMI HIROSHI、AMANO SHIGERU、IIJIMA YOSUKE、SANO MOTOHIKO、UESAWA YOSHIHIRO、TAMURA NOBUAKI、OISHI YOHEI、TAKESHIMA HIROSHI
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 2 Pages: 781-790
- DOI
  10.21873/anticanres.15536
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides2021
- Author(s)
  Yamali Cem、Sakagami Hiroshi、Uesawa Yoshihiro、Kurosaki Kota、Satoh Keitaro、Masuda Yoshiko、Yokose Satoshi、Ece Abdulilah、Bua Silvia、Angeli Andrea、Supuran Claudiu T.、Gul Halise Inci
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 217 Pages: 113351-113351
- DOI
  10.1016/j.ejmech.2021.113351
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Deep learning-based in vitro detection method for cellular impurities in human cell-processed therapeutic products2021
- Author(s)
  Matsuzaka, Y., Kusakawa, S., Uesawa, Y., Sato, Y., Satoh, M.
- Journal Title
  
  Applied Sciences
  
  Volume: 11(20) Issue: 20 Pages: 9755-9755
- DOI
  10.3390/app11209755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07177, KAKENHI-PROJECT-21K12767
[Journal Article] 腫瘍選択性が高く、副作用が低い新規クロモン誘導体の開発2020
- Author(s)
  坂上宏、杉田義昭、高尾浩一、永井純子、植沢芳広、飯島洋介、佐野元彦
- Journal Title
  
  New Food Industry
  
  Volume: 62 (12) Pages: 871-881
- NAID
  40022428470
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma2020
- Author(s)
  Sugita Yoshiaki、Takao Koichi、Uesawa Yoshihiro、Nagai Junko、Iijima Yosuke、Sano Motohiko、Sakagami Hiroshi
- Journal Title
  
  Medicines
  
  Volume: 7 Issue: 9 Pages: 50-50
- DOI
  10.3390/medicines7090050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] QSAR Prediction Model to Search for Compounds with Selective Cytotoxicity Against Oral Cell Cancer2019
- Author(s)
  Nagai Junko、Imamura Mai、Sakagami Hiroshi、Uesawa Yoshihiro
- Journal Title
  
  Medicines
  
  Volume: 6 Issue: 2 Pages: 45-45
- DOI
  10.3390/medicines6020045
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、UESAWA YOSHIHIRO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 7 Pages: 3897-3906
- DOI
  10.21873/anticanres.12674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] 3-( E )-Styryl-2 H -chromene derivatives as potent and selective monoamine oxidase B inhibitors2018
- Author(s)
  Takao Koichi、Yahagi Hideaki、Uesawa Yoshihiro、Sugita Yoshiaki
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 77 Pages: 436-442
- DOI
  10.1016/j.bioorg.2018.01.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones2018
- Author(s)
  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y
- Journal Title
  
  Anticancer Res
  
  Volume: 38(6) Issue: 6 Pages: 3283-3290
- DOI
  10.21873/anticanres.12593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones2018
- Author(s)
  NAGAI JUNKO、SHI HAIXIA、KUBOTA YUKA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 8 Pages: 4449-4457
- DOI
  10.21873/anticanres.12747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] In Vitro Anti-tumor Activity of Azulene Amide Derivatives2018
- Author(s)
  Wada T1, Maruyama R1, Irie Y1, Hashimoto M1, Wakabayashi H2, Okudaira N3, Uesawa Y4, Kagaya H4, Sakagami H5.
- Journal Title
  
  In Vivo
  
  Volume: 32 Issue: 3 Pages: 479-486
- DOI
  10.21873/invivo.11264
- NAID
  120006518155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] <b>Analysis of physicochemical properties of drugs included in anticholinergic rating scales</b>2018
- Author(s)
  永井純子、加賀谷肇、植沢芳広
- Journal Title
  
  Chem-Bio Informatics Journal
  
  Volume: 18 Issue: 0 Pages: 1-9
- DOI
  10.1273/cbij.18.1
- NAID
  130006307531
- ISSN
  1347-0442, 1347-6297
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] :Quantitative structure-cytotoxicity relationship of 2-azolylchromones2018
- Author(s)
  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 2 Pages: 763-770
- DOI
  10.21873/anticanres.12282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Recent Progress of Basic Studies of Natural Products and Their Dental Application.2018
- Author(s)
  Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.
- Journal Title
  
  Medicines (Basel)
  
  Volume: 6 Issue: 1 Pages: 4-4
- DOI
  10.3390/medicines6010004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09843, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative structure-cytotoxicity relationship of cinnamic acid phenetyl esters2018
- Author(s)
  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 2 Pages: 817-823
- DOI
  10.21873/anticanres.12289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 8 Pages: 4459-4467
- DOI
  10.21873/anticanres.12748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Adverse Effect Predictions Based on Computational Toxicology Techniques and Large-scale Databases2018
- Author(s)
  植沢芳広
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 138 Issue: 2 Pages: 185-190
- DOI
  10.1248/yakushi.17-00174-4
- NAID
  130006327944
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-02-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Establishment of a Direct-Injection Electron Ionization-Mass Spectrometry Metabolomics Method and Its Application to Lichen Profiling2017
- Author(s)
  Kai Hisahiro、Kinoshita Kaoru、Harada Hiroshi、Uesawa Yoshihiro、Maeda Akihiro、Suzuki Ryuichiro、Okada Yoshihito、Takahashi Kunio、Matsuno Koji
- Journal Title
  
  Analytical Chemistry
  
  Volume: 89 Issue: 12 Pages: 6408-6414
- DOI
  10.1021/acs.analchem.7b00077
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Aurones2017
- Author(s)
  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 11 Pages: 6169-6176
- DOI
  10.21873/anticanres.12066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-cytotoxicity relationship of newly synthesized piperic acid esters.2017
- Author(s)
  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, and Sugita Y.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 11 Pages: 6161-6168
- DOI
  10.21873/anticanres.12065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K01319, KAKENHI-PROJECT-15K08111
[Journal Article] Search for new type of anticancer drugs with high tumor-specificity and less keratinocyte toxicity (Review)2017
- Author(s)
  Sugita Y, Takao K, Uesawa Y and Sakagami H
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 11 Pages: 5919-5924
- DOI
  10.21873/anticanres.12038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Chalcones2017
- Author(s)
  Sakagami H, Masuda Y,Tomomura M,Yokose S, Uesawa Y,Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H,and Sugita T.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 3 Pages: 1091-1098
- DOI
  10.21873/anticanres.11421
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Computational Toxicology: Basics and Current Status2017
- Author(s)
  植沢芳広
- Journal Title
  
  Journal of Pharmaceutical Science and Technology, Japan
  
  Volume: 77 Issue: 5 Pages: 270-274
- DOI
  10.14843/jpstj.77.270
- NAID
  130006044036
- ISSN
  0372-7629, 2188-3149
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] High-Performance Prediction of Human Estrogen Receptor Agonists Based on Chemical Structures2017
- Author(s)
  Yuki Asako、Yoshihiro Uesawa
- Journal Title
  
  Molecules
  
  Volume: 22 Issue: 4 Pages: 675-675
- DOI
  10.3390/molecules22040675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Characterization of the Adverse Effects Induced by Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs Based on the Analysis of the Japanese Adverse Drug Event Report Database2017
- Author(s)
  Nagai Junko、Uesawa Yoshihiro、Shimamura Ryotaro、Kagaya Hajime
- Journal Title
  
  The Clinical Journal of Pain
  
  Volume: 33 Issue: 8 Pages: 667-675
- DOI
  10.1097/ajp.0000000000000457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Electron ionization mass spectrometry based metabolomics studies of Sophora flavescens can identify the geographical origin of root samples2016
- Author(s)
  Suzuki R, Kai H, Uesawa Y, Matsuno K, Okada Y, Shirataki Y
- Journal Title
  
  Nat Prod Commun
  
  Volume: 11 Pages: 73-75
- NAID
  120005895945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Electron Ionization Mass Spectrometry-based Metabolomics Studies of Sophoraflavescens can Identify the Geographical Origin of Root Samples.2016
- Author(s)
  Suzuki R, Kai H, Uesawa Y, Matsuno K, Okada Y, Shirataki Y.
- Journal Title
  
  Nat Prod Commun.
  
  Volume: 11 Pages: 73-5
- NAID
  120005895945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Antiviral and antitumor activity of licorice root extracts2016
- Author(s)
  Fukuchi K, Okudaira N , Adachi K, Odai-Ide R, Watanabe S, Ohno H Yamamoto M, Kanamoto T , Terakubo S , Nakashima H , Uesawa Y, Kagaya H, Sakagami H,
- Journal Title
  
  in vivo
  
  Volume: 4 Pages: 777-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Rigorous selection of random forest models for identifying compounds that activate toxicity-related pathways2016
- Author(s)
  Uesawa Y
- Journal Title
  
  Front Environ Sci
  
  Volume: 4 Pages: 1-6
- DOI
  10.3389/fenvs.2016.00009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Electron Ionization Mass Spectrometry-based Metabolomics Studies of Sophoraflavescens can Identify the Geographical Origin of Root Samples2016
- Author(s)
  Suzuki R, Kai H, Uesawa Y, Matsuno K, Okada Y, Shirataki Y.
- Journal Title
  
  Nat Prod Commun
  
  Volume: 11 Pages: 73-75
- NAID
  120005895945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] 呼吸器領域がん患者における予測クレアチニンクリアランスの推奨算出法の検討2016
- Author(s)
  矢島愛理、植沢芳広、稲野寛、益田典幸、尾鳥勝也、厚田幸一郎、加賀谷肇
- Journal Title
  
  日本緩和医療薬学雑誌
  
  Volume: 9 Pages: 17-23
- NAID
  40020820876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] オピオイドの分布容積を予測する：定量的構造動態相関注解2016
- Author(s)
  植沢芳広
- Journal Title
  
  日本緩和医療薬学雑誌
  
  Volume: 9 Pages: 1-10
- NAID
  40020820827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-cytotoxicity relationship of 3-benzylidenechromanones2016
- Author(s)
  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y
- Journal Title
  
  Anticancer Res
  
  Volume: 36 Issue: 11 Pages: 5803-5812
- DOI
  10.21873/anticanres.11164
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111, KAKENHI-PROJECT-16K11519
[Journal Article] 計算毒性学コンペティションにおける定量的構造毒性相関モデルの構築と評価2016
- Author(s)
  植沢芳広
- Journal Title
  
  CBI 学会誌
  
  Volume: 4 Pages: 4-7
- Open Access
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] 薬物治療における医薬品の安全使用に向けた実践と新たな取り組み2016
- Author(s)
  大石智洋、莚田泰誠、田村浩司、植沢芳広、佐藤光利
- Journal Title
  
  日本医薬品安全性学会会誌
  
  Volume: 2 Pages: 23-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Oleoylamides2015
- Author(s)
  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y.
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 5341-5351
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Analyses of opioid-induced adverse effects based on Japanese Adverse Drug Event Report database：Distinctive tendencies of the adverse events induced by morphine, fentanyl and oxycodone2015
- Author(s)
  永井純子, 植沢芳広, 加賀谷肇
- Journal Title
  
  Palliat Care Res
  
  Volume: 10 Issue: 1 Pages: 113-119
- DOI
  10.2512/jspm.10.113
- NAID
  130004943678
- ISSN
  1880-5302
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Construction of a model for predicting creatinine clearance in Japanese patients treated with Cisplatin therapy2015
- Author(s)
  Yajima A, Uesawa Y, Ogawa C, Yatabe M, Kondo N, Saito S, Suzuki Y, Atsuda K, Kagaya H.
- Journal Title
  
  Construction of a model for predicting creatinine clearance in Japanese patients treated with Cisplatin therapy
  
  Volume: 35 Pages: 2909-2914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Predictive performance of three practical approaches for grapefruit juice-induced 2-fold or greater increases in AUC of concomitantly administered drugs2015
- Author(s)
  Takahashi M, Onozawa S, Ogawa R, Uesawa Y, Echizen H.
- Journal Title
  
  J Clin Pharm Ther
  
  Volume: 40 Issue: 1 Pages: 91-97
- DOI
  10.1111/jcpt.12231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] 副作用データベースに基づくオキシコドンの副作用発現傾向の解析2015
- Author(s)
  永井純子, 植沢芳広, 加賀谷肇
- Journal Title
  
  Palliative Care Research
  
  Volume: 10 Issue: 3 Pages: 161-168
- DOI
  10.2512/jspm.10.161
- NAID
  130005093301
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08111, KAKENHI-PROJECT-25460227
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.2015
- Author(s)
  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 5299-307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Construction of a model for predicting creatinine clearance in Japanese patients treated with Cisplatin therapy.2015
- Author(s)
  Yajima A, Uesawa Y, Ogawa C, Yatabe M, Kondo N, Saito S, Suzuki Y, Atsuda K, Kagaya H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 2909-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.2015
- Author(s)
  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 5299-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes2015
- Author(s)
  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 5299-5307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-activity relationship analysis of cytotoxicity and anti- UV activity of 2-aminotropones2014
- Author(s)
  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H
- Journal Title
  
  Anticancer Res.
  
  Volume: 34 Pages: 1743-1750
- NAID
  120005520960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Quantitative structure-cytotoxicity relationship of 3-styrylchromone2014
- Author(s)
  Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H
- Journal Title
  
  Anticancer Res.
  
  Volume: 34, Pages: 5405-5411
- NAID
  120005520991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] 今改めて考える、がん疼痛治療におけるオピオイド鎮痛薬の使い方　オキシコドンの体内動態に影響を及ぼす併用薬2014
- Author(s)
  植沢芳広、加賀谷肇
- Journal Title
  
  がん患者と対症療法
  
  Volume: 25 Pages: 58-64
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] 生理的pH条件下の電荷に基づくオピオイドの分布容積の評価2014
- Author(s)
  植沢芳広，加賀谷肇
- Journal Title
  
  日本緩和医療薬学雑誌
  
  Volume: 7 Pages: 55-61
- NAID
  40020223868
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Construction of a Prediction Model for Waiting Time of Patients Based on Analyses of Dispensing in a Health Insurance Pharmacy2014
- Author(s)
  植沢芳広，内田明宏，小山　茜，宇田川三男，武田直子，富澤　崇
- Journal Title
  
  Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
  
  Volume: 40 Issue: 4 Pages: 215-221
- DOI
  10.5649/jjphcs.40.215
- NAID
  130005062829
- ISSN
  1346-342X, 1882-1499
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Quantitative structure-cytotoxicity relationship of piperic acid amides2014
- Author(s)
  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H
- Journal Title
  
  Anticancer Res.
  
  Volume: 34 Pages: 4877-4884
- NAID
  120005520990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Journal Article] Evaluation of Cytotoxiciy and Tumor-Specificity of Licorice Flavonoids Based on Chemical Structure2013
- Author(s)
  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 3061-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 副作用データベースと化学構造情報を用いた重症皮膚副作用の発症抑制に寄与する生化学的要因の解析2023
- Author(s)
  利根川理紗、朝田瑞穂、植沢芳広
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 副作用データベースおよび機械学習を用いた掻痒症誘発薬における構造的特徴の解析2023
- Author(s)
  中尾百合子，黒崎　宏太, 朝田　瑞穂, 植沢芳広
- Organizer
  日本医療薬学会第6回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 副作用データベース研究事始め2023
- Author(s)
  植沢芳広
- Organizer
  第9回日本医薬品安全性学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] AI Modeling of Structure-Toxicity Relationship with Adverse Outcome Pathway (AOP) Concepts2023
- Author(s)
  植沢芳広
- Organizer
  2023 Fall Convention of KOSEHT
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 副作用データベースを用いた毒性発現経路の推定と大規模言語モデルの活用2023
- Author(s)
  植沢芳広
- Organizer
  CBI学会2023年大会　フォーカストセッション
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 化学構造情報を用いたヒト口腔扁平上皮癌由来細胞に対する腫瘍選択性に寄与する生化学的要因の解析2023
- Author(s)
  工藤未空、伊藤広貴、植沢芳広、坂上宏
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K09885
[Presentation] Development of DeepSnap, a novel in silico technology for predicting toxicity from chemical structures2023
- Author(s)
  植沢芳広
- Organizer
  25th International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] AIと化学物質の構造情報を活用した新時代の毒性予測戦略2023
- Author(s)
  植沢芳広
- Organizer
  第64回大気環境学会　健康影響分科会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 共培養細胞を用いた異常細胞の高感度検出方法に関する検討2023
- Author(s)
  佐藤光利、草川森士、佐藤陽治、松坂恭成、植沢芳広
- Organizer
  第24回応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06751
[Presentation] 機械学習を用いたQSAR予測モデルに基づく口腔扁平上皮癌由来細胞に対する選択的毒性に関連する化学構造の探索2023
- Author(s)
  伊藤広貴、工藤未空、黒崎宏太、植沢芳広、坂上宏
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K09885
[Presentation] 毒性・副作用研究における人工知能の有用性2023
- Author(s)
  植沢芳広
- Organizer
  第67回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] Analysis of toxicity induction mechanisms based on drug adverse event database2023
- Author(s)
  植沢芳広
- Organizer
  MOE forum 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] Quantitative Structure-Activity Relationship analysis using molecular images2022
- Author(s)
  Uesawa Y, Matsuzaka Y
- Organizer
  International Congress on Pure & Applied Chemistry Kota Kinabalu ICPAC KK 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] ケモインフォマティクスを活用した機械学習による化学構造の毒性評価2022
- Author(s)
  植沢芳広
- Organizer
  第43回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 副作用データベースを用いた重症皮膚副作用を誘発する医薬品の網羅的解析2022
- Author(s)
  利根川理紗、朝田瑞穂、植沢芳広
- Organizer
  第8回日本医薬品安全性学会学術大会
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] ３D細胞培養による細胞表現型の違いを指標にした異常細胞識別の検討2022
- Author(s)
  佐藤光利、草川森士、佐藤陽治、松坂恭成、植沢芳広
- Organizer
  第23回応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06751
[Presentation] 分子画像を用いた QSAR 解析：DeepSnap 法の開発の現状2022
- Author(s)
  植沢芳広
- Organizer
  CBI学会2022年大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] Comprehensive analysis of the drugs that may induce severe cutaneous adverse reactions using the adverse drug event report database2022
- Author(s)
  Tonegawa R, Uesawa Y
- Organizer
  CBI学会2022年大会
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] DXを通した薬理学の未来～ビッグデータと化学構造解析が拓く毒性・副作用研究～2022
- Author(s)
  植沢芳広
- Organizer
  第96回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06707
[Presentation] 足場非依存的コロニー形成試験における異常細胞コロニーの深層学習による画像識別モデルの評価2021
- Author(s)
  草川森士、松坂恭成、植沢芳広、佐藤陽治、佐藤光利
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07177
[Presentation] ヒト口腔扁平上皮がん細胞に対する抗がん剤および過酸化水素とマイルドハイパーサーミアの併用効果2021
- Author(s)
  田川裕也、坂上宏、天野滋、友村美根子、坂東健二郎、高尾浩一、杉田義昭、植沢芳広、山本信治、坂下英明、中鍛治里奈、小泉敏之、光藤健司、藤内祝
- Organizer
  ハイパーサーミア学会
- Data Source
  KAKENHI-PROJECT-20H03893
[Presentation] 畳み込みニューラルネットワークを用いた異常細胞識別に関する検討2021
- Author(s)
  草川森士、松坂恭成、植沢芳広、佐藤陽治、佐藤光利
- Organizer
  第22回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07177
[Presentation] 口腔癌選択毒性を示す化合物の探索を目的としたQSAR予測モデルの構築2019
- Author(s)
  今村舞衣、永井純子、坂上宏、植沢芳広
- Organizer
  第139回薬学会年会、幕張、千葉
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 2-(N-cyclicamino)chromone誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  植沢芳広、史海霞、永井純子、坂詰つかさ、坂東健二郎、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 副作用データベースJADERを用いた薬剤性せん妄に関する化学構造情報解析2018
- Author(s)
  瀬田　優香、加賀谷肇、植沢芳広
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 医薬品副作用データベースを用いた薬剤性便秘類似疾患の分類評価2018
- Author(s)
  小津　吉泰、加賀谷肇、植沢芳広
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 3-(N-サイクリックアミノ)クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  坂上宏、史　海霞、永井純子、坂詰つかさ、坂東健二郎、奥平　准之、植沢芳広、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ピラノ[4,3-b]クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  永井純子、史海霞、久保田夕香、坂東健二郎、奥平准之、植沢芳広、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] フラノクロモン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、高尾浩一、杉田義、加賀谷肇、奥平准之、坂上宏
- Organizer
  第138回日本薬理学会関東部会、慶応義塾大学薬学部、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 人工知能で挑む有害作用発現経路の解析2017
- Author(s)
  植沢芳広
- Organizer
  第44回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 大規模副作用情報および化学構造情報の融合が拓く医薬品の安全性予測2017
- Author(s)
  植沢芳広
- Organizer
  第24回HAB学術年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 緩和医療薬学分野における大規模医薬品副作用データベースJADERの活用2017
- Author(s)
  植沢芳広
- Organizer
  第11回日本緩和医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] オーロン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、坂上宏、池添成彦、高尾浩一、加賀谷肇、杉田義昭
- Organizer
  第137回日本薬理学会関東部会、日本医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 毒性発現経路および化学構造情報を指標としたヒト有害反応の予測法の開発2017
- Author(s)
  植沢芳広
- Organizer
  日本化学工業協会・新LRI第5期研究報告会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] ピペリン酸エステル誘導体の構造活性相関：腫瘍選択性とアポトーシス誘導2017
- Author(s)
  坂上宏、植沢芳広、増田宜子、友村美根子、金本大成、寺久保繁美、宮城昂幹、村井淳一、高尾浩一、横瀬敏志、加賀谷肇、中島秀喜、杉田義昭
- Organizer
  第137回日本薬理学会関東部会、日本医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 核内受容体およびストレス応答パスウェイを介した肝毒性予測における人工知能技術の適用2017
- Author(s)
  植沢芳広
- Organizer
  第6回生命医薬情報学連合大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 大規模医薬品副作用データベースを用いたアナフィラキシーの誘因となる化学構造の解析2016
- Author(s)
  阿部剛、植沢芳広、加賀谷肇
- Organizer
  第10回緩和医療薬学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 医薬品副作用データベースに基づくがん患者における消化管障害を惹起する医薬品の評価2016
- Author(s)
  永井純子、植沢芳広、加賀谷肇
- Organizer
  第26回日本医療薬学会年会
- Place of Presentation
  京都
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Tox21 Challenge To Build Predictive Models of Nuclear Receptor and Stress Response Pathways As Mediated by Exposure to Environmental Toxicants and Drugs2016
- Author(s)
  Uesawa Y
- Organizer
  The Society of Toxicology 55th Annual Meeting and ToxExpo
- Place of Presentation
  New Orleans
- Year and Date
  2016-03-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 毒性予測モデルの構築における化学構造の取扱い2016
- Author(s)
  植沢芳広
- Organizer
  情報計算化学生物学会2016年大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Search for Bioactive Components from Ephedra Species against Adult T-cell Leukemia using Electron Ionization (EI)-MS- and NMR-based Metabolomics2016
- Author(s)
  Kai H, Maeda A, Uesawa Y, Okada Y, Morishita K, Matsuno K
- Organizer
  9th Joint Natural Products Conference
- Place of Presentation
  Copenhagen
- Year and Date
  2016-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 患者背景情報および併用薬がオピオイドの呼吸抑制発現リスクに与える影響2016
- Author(s)
  海野啓太、植沢芳広、永井純子、加賀谷肇
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] ランダムフォレスト法を用いたPPAR-γ受容体活性化合物の高精度予測モデル構築方法の検討2016
- Author(s)
  青木雅弥、植沢芳広、加賀谷肇
- Organizer
  第10回緩和医療薬学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Dragon記述子が拓く計算毒性学の世界2016
- Author(s)
  植沢芳広
- Organizer
  Dragon分子記述の活用セミナー
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 大規模副作用情報に基づく副作用誘発化学構造の解析：アナフィラキシーを例として2016
- Author(s)
  植沢芳広
- Organizer
  情報計算化学生物学会2016年大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Study of concomitant drugs using machine learning QSAR analyses to facilitate brain penetration of morphine2016
- Author(s)
  Uesawa Y
- Organizer
  World Congress & Expo on Pharmaceutics & Drug Delivery Systems (Pharmaceutics-2016)
- Place of Presentation
  Dubai
- Year and Date
  2016-04-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Study of Effects of NF-κB for Reporting Frequency of Adverse Drug Reactions based on Tox21-AOP Database2016
- Author(s)
  Jun Teraoka, Yurie Yoshida, Ryota Higuchi, Yuhei Mashiyama, Yoshihiro Uesawa
- Organizer
  情報計算化学生物学会2016年大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 医薬品副作用データベースに基づくがん患者に発現する消化器障害と医薬品の関連性評価2016
- Author(s)
  永井純子、植沢芳広、加賀谷肇
- Organizer
  第4回東京都緩和医療研究会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] JMPの機械学習機能を用いた高精度毒性予測法の開発2016
- Author(s)
  植沢芳広
- Organizer
  Japan Discovery Summit
- Place of Presentation
  東京
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 機械学習に基づくモルヒネの中枢移行性促進に有用な併用薬の探索2016
- Author(s)
  植沢芳広, 福島大介, 野澤（石井）玲子, 加賀谷肇
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 基礎データからの有害発生予測と医薬品副作用データベースに基づく有害事象解析2016
- Author(s)
  植沢芳広
- Organizer
  第2回日本医薬品安全性学会学術大会
- Place of Presentation
  岐阜
- Year and Date
  2016-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 大規模副作用データベースに基づく吃逆誘発因子の解析2016
- Author(s)
  細谷龍一郎、植沢芳広、野澤（石井）玲子、加賀谷肇
- Organizer
  第10回緩和医療薬学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 大規模副作用情報データベースに基づく吃逆誘発因子の解析2016
- Author(s)
  細谷龍一郎、植沢芳広、野澤（石井）玲子、加賀谷肇
- Organizer
  第4回東京都緩和医療研究会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Analyses of Chemical Properties Associated with Reporting Frequency of Erythema Exudativum Multiforme Major in Adverse Drug Reaction Database2016
- Author(s)
  Yuhei Mashiyama, Yurie Yoshida, Ryota Higuchi, Jun Teraoka, Yoshihiro Uesawa
- Organizer
  情報計算化学生物学会2016年大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 甘草含有成分の抗ヘルペスウイルス活性に対する定量的構造活性相関解析2016
- Author(s)
  植沢芳広、福地邦彦、坂上宏、加賀谷肇、大野裕和、山本正次
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] JADERに基づく非がん患者とがん患者でのオピオイド依存の比較2016
- Author(s)
  田村有梨、野澤（石井）玲子、植沢芳広、加賀谷肇
- Organizer
  第4回東京都緩和医療研究会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 化学構造の機械学習に基づく毒性発現経路の高精度予測2016
- Author(s)
  植沢芳広
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Analyses of Chemical Properties Associated with Reporting Frequency of Interstitial Lung Disease in Adverse Drug Reaction Database2016
- Author(s)
  Ryota Higuchi, Yurie Yoshida, Jun Teraoka, Yuhei Mashiyama, Yoshihiro Uesawa
- Organizer
  情報計算化学生物学会2016年大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] オピオイドの呼吸抑制発現に関するリスク因子の解析2016
- Author(s)
  海野啓太、植沢芳広、永井純子、加賀谷肇
- Organizer
  第10回緩和医療薬学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 3-Benzylidenechromanonesの定量的構造‐細胞傷害性相関解析2016
- Author(s)
  植沢芳広、坂上宏、山下毬藻、高尾浩一、杉田義昭
- Organizer
  第134回日本薬理学会関東部会
- Place of Presentation
  国際医療福祉大学薬学部、大田原市、栃木
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] Analyses of Chemical Properties for Reporting Frequency of Thrombocytopenia in Adverse Drug Reaction Database2016
- Author(s)
  Yurie Yoshida, Ryota Higuchi, Jun Teraoka, Yuhei Mashiyama, Yoshihiro Uesawa
- Organizer
  情報計算化学生物学会2016年大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Tox21 Challenge To Build Predictive Models of Nuclear Receptor and Stress Response Pathways As Mediated by Exposure to Environmental Toxicants and Drugs2016
- Author(s)
  Uesawa Y
- Organizer
  The Society of Toxicology 55th Annual Meeting and ToxExpo
- Place of Presentation
  New Orleans
- Year and Date
  2016-03-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Prediction for Activators of Adverse Outcome Pathways based on the Tox21 10K Compound Library2016
- Author(s)
  Uesawa Y, Asako Y, Aoki M
- Organizer
  ICCA-LRI and NIHS Workshop
- Place of Presentation
  Awaji
- Year and Date
  2016-06-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 米国毒性予測コンペティション“Tox21 DATA Challenge 2014”参加報告2015
- Author(s)
  植沢芳広
- Organizer
  CBI学会2015年大会
- Place of Presentation
  東京
- Year and Date
  2015-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 大規模毒性関連データベースに基づくQSAR予測モデルの構築2015
- Author(s)
  植沢芳広
- Organizer
  MOEフォーラム2015
- Place of Presentation
  東京
- Year and Date
  2015-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 2.Volume of distribution of opioids administered in humans can be estimated by electric charge under biological pH conditions2015
- Author(s)
  Uesawa Y, Kagaya H
- Organizer
  14th World Congress of the European Association for Palliative Care (EAPC2015)
- Place of Presentation
  Denmark
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 3.Analyses of opioid-induced adverse effects based on PMDA Japanese Adverse Drug Event Report database (JADER) in Japanese patients receiving palliative care2015
- Author(s)
  Nagai J, Uesawa Y, Kagaya H
- Organizer
  14th World Congress of the European Association for Palliative Care
- Place of Presentation
  Denmark
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 大規模データベースに基づく吃逆誘発因子の解析2015
- Author(s)
  細谷龍一郎、植沢芳広、野澤(石井)玲子、加賀谷肇
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 医薬品副作用データベースに基づくせん妄に起因する医薬品の解析2015
- Author(s)
  田村有梨、慶　元箕、増田多加子、永井純子、野澤（石井）玲子、植沢芳広、加賀谷肇
- Organizer
  第9回緩和医療薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 医薬品副作用データベースに基づくNSAIDsによる副作用の特徴解析2015
- Author(s)
  永井純子、島村遼太郎、植沢芳広、加賀谷肇
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] Study of concomitant drugs using machine learning QSAR analyses to facilitate brain penetration of morphine2015
- Author(s)
  Uesawa Y
- Organizer
  World Congress & Expo on Pharmaceutics & Drug Delivery Systems
- Place of Presentation
  Dubai
- Year and Date
  2015-04-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 医薬品副作用データベースに基づくアセトアミノフェンの副作用の特徴解析2015
- Author(s)
  永井純子、島村遼太郎、植沢芳広、加賀谷肇
- Organizer
  第9回緩和医療薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 医薬品副作用データベースに基づくNSAIDsとアセトアミノフェンの副作用発現傾向の比較2015
- Author(s)
  植沢芳広、島村遼太郎、永井純子、加賀谷肇
- Organizer
  第9回緩和医療薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 大規模毒性関連データベースに基づくQSAR予測モデルの構築2015
- Author(s)
  植沢芳広
- Organizer
  MOEフォーラム2015
- Place of Presentation
  東京
- Year and Date
  2015-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 3.Analyses of opioid-induced adverse effects based on PMDA Japanese Adverse Drug Event Report database (JADER) in Japanese patients receiving palliative care2015
- Author(s)
  Nagai J, Uesawa Y, Kagaya H
- Organizer
  14th World Congress of the European Association for Palliative Care (EAPC2015)
- Place of Presentation
  Denmark
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 米国毒性予測コンペティション“Tox21 DATA Challenge 2014”参加報告2015
- Author(s)
  植沢芳広
- Organizer
  情報計算化学生物学会2015年大会
- Place of Presentation
  東京
- Year and Date
  2015-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K08111
[Presentation] 2.Volume of distribution of opioids administered in humans can be estimated by electric charge under biological pH conditions2015
- Author(s)
  Uesawa Y, Kagaya H
- Organizer
  14th World Congress of the European Association for Palliative Care
- Place of Presentation
  Denmark
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] ビッグデータを副作用対策に活かす～多変量解析およびデータマイニング手法を用いて副作用を予想する～2014
- Author(s)
  植沢芳広
- Organizer
  がんの痛みと症状緩和に関する多施設共同臨床研究会学術大会SCORE-G Summer Seminar in KARUIZAWA
- Place of Presentation
  軽井沢
- Year and Date
  2014-08-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 化学構造に基づくオピオイド関連化合物の分布容積推定モデルの構築2013
- Author(s)
  植沢芳広、石井みゆき、加賀谷肇
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 構造式から推定するオピオイドの体内動態予測 ― 平均残留時間および血漿中半減期について ―2013
- Author(s)
  植沢芳広、加賀谷肇
- Organizer
  第7回日本緩和医療薬学会年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] マルチコンパートメントモデルに従う薬物の特徴の解析2013
- Author(s)
  植沢芳広、加賀谷肇
- Organizer
  第23回日本医療薬学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] Quantitative Structure-pharmacokinetic Relationships (QSPkR) Analysis of Opioids2013
- Author(s)
  Yoshihiro Uesawa, Miyuki Ishii, Hajime Kagaya
- Organizer
  CBI学会2013年大会 -生命医薬情報学連合大会-
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] ラット脳／血漿間非結合形薬物濃度比に基づくヒト脳移行性の推定2013
- Author(s)
  植沢芳広、加賀谷肇
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 32.オピオイドの効率的な中枢移行寄与コンパニオンドラッグの探索を指向したトランスポーター制御化合物予測モデルの構築
- Author(s)
  福島大介、植沢芳広、加賀谷肇
- Organizer
  第8回日本緩和医療薬学会年会
- Place of Presentation
  松山
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 33.医薬品副作用データベースに基づくオピオイドの副作用発現における性差の解析
- Author(s)
  永井純子、植沢芳広、曽我部直美、加賀谷肇
- Organizer
  第8回日本緩和医療薬学会年会
- Place of Presentation
  松山
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-25460227
[Presentation] 14.我が国の医薬品副作用報告に基づくオピオイドの客観的副作用発現頻度解析
- Author(s)
  植沢芳広、加賀谷肇
- Organizer
  第19回日本緩和医療学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2014-06-19 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-25460227

1. Sakagami Hiroshi (50138484)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
2. OKUDIRA NORIYUKI (10635585)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. BANDOW KENJIRO (50347093)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. 杉田義昭 (20255029)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
5. 高尾浩一 (70337484)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
6. Kagaya Hajime (00642969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 50 results
7. NAGAI JUNKO (50828142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
8. SATOH Mitsutoshi (60231346)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. 友村美根子 (30217559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
10. 天野滋 (90167958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
11. NOZAWA Reiko (60257144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Tohnai Iwai (50172127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 杉本昌弘 (30458963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 須永克佳 (70236040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 田沼靖一 (10142449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 佐藤聡 (40530663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. 山本信治 (60385185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 小泉敏之 (80323575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 中鍛治里奈 (80845511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 坂下英明 (10178551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 友村明人

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
23. 石井玲子

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
24. 須田直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uesawa Yoshihiro 植沢 芳広

UESAWA Yoshihiro 植沢 芳広

Research Projects

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リアルワールドデータに基づく重症皮膚副作用発症機序の解明と予測法の開発Principal Investigator

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Search for characteristic markers of stem cell and cell validation by prediction of cell characteristics using AI

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Elucidation of selective cytotoxicity against malignant cells by chromone derivatives

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Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles

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Search for characteristic markers of stem cells for use in cell therapeutics and improvement of validation accuracy by AI

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Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer

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Adverse Reactions to Potent Opioids: An analysis using the largescale Japanese Adverse Drug Event Report databasePrincipal Investigator

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A study on concomitant drugs to improve the analgesic effects and decrease the side effects of morphine

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[Book] ケモインフォマティクスにおける データ収集の最適化と解析手法2023

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[Book] in silico創薬におけるスクリーニングの高速化・高精度化技術2018

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[Book] In Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs2017

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[Book] 緩和医療薬学-SCIENCEとARTの融合と実践-2016

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[Book] 緩和医療薬学-SCIENCEとARTの融合と実践-2016

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Uesawa Yoshihiro 植沢芳広

UESAWA Yoshihiro 植沢芳広

[Book] ケモインフォマティクスにおけるデータ収集の最適化と解析手法2023