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Isono Kyoichi  磯野 協一

… Alternative Names

ISONO Kyoichi  磯野 協一

磯野 協一  イソノ キヨウイチ

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Researcher Number 90323435
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4609-8985
Affiliation (Current) 2025: 和歌山県立医科大学, 共同利用施設, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 和歌山県立医科大学, 共同利用施設, 准教授
2016: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 客員研究員
2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員
2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員
2006 – 2012: 独立行政法人理化学研究所, 免疫器官形成研究グループ, 上級研究員 … More
2007: The Institute of Physical and Chemical Research, 免疫器官形成研究グループ, 上級研究員
2004: 独立行政法人理化学研究所, 免疫器官形成研究グループ, 研究員
2003: 千葉大学, 遺伝子実験施設, 助手
2001: 千葉大学, 遺伝子実験施設, 助手 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Biological Sciences / Basic Section 48040:Medical biochemistry-related / Basic Section 44020:Developmental biology-related / Cell biology
Except Principal Investigator
Science and Engineering
Keywords
Principal Investigator
ポリコーム / ポリコーム群 / エピジェネティクス / ノックアウトマウス / 発現制御 / 遺伝子制御 / ヒストン修飾 / 遺伝子発現制御 / がん / 遺伝子ターゲティング … More / mRNAスプライシング / ES細胞 / Hipk / ゲノム編集マウス / MEF / Ink4a / 細胞老化 / マウスES細胞 / コヒーシン / loop extrusion / DNA修復 / ゲノム高次構造 / 幹細胞 / DNA損傷修復 / enigenetics / gene targeting / live cell imaging / Polycomb / エピジェネティック抑制 / 生細胞イメージング / 遺伝子抑制 / エネルギー代謝 / 核ドメイン / 細胞イメージング / クロマチン / 核内ドメイン / クロマチン高次構造 / 分子イメージング / エピジェネティック / 遺伝子改変マウス / スプライシング / UV誘導アポトーシス / CtBP1 / p53 / リン酸化 / マウス / 染色体免疫沈降 / ホメオボックス / 核マトリックス … More
Except Principal Investigator
胎児曝露 / 内分泌攪乱物質 / マイクロアレイ / 発生分化 / 生体機能利用 / 環境 / 遺伝子 / DNAマイクロアレイ / 遺伝子発現 / リスクコミュニケーション / DNAメチル化 / バイオマーカー / 精子形成 / ヒト臍帯 / 植物エストロゲン / ダイオキシン / 内分泌撹乱物質 Less
  • Research Projects

    (12 results)
  • Research Products

    (46 results)
  • Co-Researchers

    (9 People)
  •  細胞老化に抵抗するエピジェネティック制御機構の解明Principal Investigator

    • Principal Investigator
      磯野 協一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Wakayama Medical University
  •  The mechanism by which the transcriptional repressor Polycomb-group protein complex maintains genome integrity in stem cellsPrincipal Investigator

    • Principal Investigator
      Isono Kyoichi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Wakayama Medical University
  •  Study for stable recruitment of Polycomb-repressive complex-1 on its target lociPrincipal Investigator

    • Principal Investigator
      Isono Kyoichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Institute of Physical and Chemical Research
  •  Roles of Polycomb-group in links between metabolism and cancerPrincipal Investigator

    • Principal Investigator
      ISONO Kyoichi
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Institute of Physical and Chemical Research
  •  Recruitment of Polycomb-group complex for stable repressionsPrincipal Investigator

    • Principal Investigator
      ISONO Kyoichi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      The Institute of Physical and Chemical Research
  •  In vivoポリコーム群複合体による抑制とその解除メカニズムの解明Principal Investigator

    • Principal Investigator
      磯野 協一
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Suz12及びスプライシング因子欠損マウスからポリコーム群複合体機能を理解するPrincipal Investigator

    • Principal Investigator
      磯野 協一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Study for molecular mechanisms of Polycomb-repressive functions by live cell imagingPrincipal Investigator

    • Principal Investigator
      ISONO Kyocihi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  アポトーシスにおけるマウスHipk1およびHipk2の役割に関する研究Principal Investigator

    • Principal Investigator
      磯野 協一
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  哺乳類ポリコーム群複合体のリン酸化とその構造および機能への影響に関する研究Principal Investigator

    • Principal Investigator
      磯野 協一
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The Institute of Physical and Chemical Research
      Chiba University
  •  内分泌撹乱物質の人体汚染における次世代への影響とリスク評価

    • Principal Investigator
      森 千里
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Chiba University
  •  哺乳類ポリコーム群が構成する核内機能ドメインの作用発現機序の解析Principal Investigator

    • Principal Investigator
      磯野 協一
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University

All 2021 2019 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.2014

    • Author(s)
      Matsunawa M, Yoshida K
    • Journal Title

      Leukemia

      Volume: (Epub ahead of print) Issue: 9 Pages: 1-7

    • DOI

      10.1038/leu.2014.73

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-12J04216, KAKENHI-PLANNED-22134006, KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659458, KAKENHI-PROJECT-25670152, KAKENHI-PROJECT-25670446, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-26640075, KAKENHI-PROJECT-26890016
  • [Journal Article] HRING1 activates Meis2 by mediating interaction of its promoter with a tissue-specific enhacer2014

    • Author(s)
      Kondo T, Isono K, Kondo K, Endo TA, Itohara S, Vidal M, Koseki
    • Journal Title

      Dev Cell

      Volume: 28 Pages: 94-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Journal Article] ポリコーム群による遺伝子抑制とエピジェネティック治療への貢献2013

    • Author(s)
      磯野協一
    • Journal Title

      遺伝子医学MOOKエピジェネティクスと病気

      Volume: 25 Pages: 37-42

    • Data Source
      KAKENHI-PROJECT-25670152
  • [Journal Article] ポリコーム群による遺伝子抑制とエピジェネティック治療への貢献2013

    • Author(s)
      磯野協一
    • Journal Title

      医学MOOK

      Volume: 25号(印刷中)

    • Data Source
      KAKENHI-PROJECT-22590278
  • [Journal Article] ポリコーム群による遺伝子抑制とエピジェネティック治療への貢献2013

    • Author(s)
      磯野協一
    • Journal Title

      遺伝子医学MOOK

      Volume: 25

    • Data Source
      KAKENHI-PROJECT-22590278
  • [Journal Article] SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing.2013

    • Author(s)
      Isono K, Endo TA, Ku M, Yamada D, Suzuki R, Sharif J, Ishikura T, Toyoda T, Bernstein BE, Koseki H.
    • Journal Title

      Dev Cell.

      Volume: 26 Issue: 6 Pages: 565-577

    • DOI

      10.1016/j.devcel.2013.08.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-25670152
  • [Journal Article] ポリコーム群による遺伝子抑制とエピジェネティック治療への貢献2013

    • Author(s)
      磯野協一
    • Journal Title

      遺伝子医学MOOK

      Volume: 25 Pages: 37-42

    • Data Source
      KAKENHI-PROJECT-25670152
  • [Journal Article] WIP1, a Homeostatic Regulator of the DNA Damage Response, Is Targeted by HIPK2 for Phosphorylation and Degradation2013

    • Author(s)
      Choi DW, Na W, Kabir MH, Yi E, Kwon S, Yeom J, Ahn JW, Choi HH, Lee Y, Seo KW, Shin MK, Park SH, Yoo HY, Isono K, Koseki H, Kim ST, Lee C, Kwon YK, Choi CY
    • Journal Title

      Mol Cell

      Volume: 51 Pages: 374-385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Journal Article] SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing2013

    • Author(s)
      Isono K, Endo AT, Ku M, Yamada D, Suzuki R, Sharif J, Ishikura T, Toyoda T, Bernstein BE, Koseki H
    • Journal Title

      Dev Cell

      Volume: 26 Pages: 565-577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Journal Article] Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity.2012

    • Author(s)
      Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H.
    • Journal Title

      PLoS Genet.

      Volume: 8 Issue: 7 Pages: e1002774-e1002774

    • DOI

      10.1371/journal.pgen.1002774

    • NAID

      120006985569

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062014, KAKENHI-PROJECT-22590278, KAKENHI-PUBLICLY-23131510, KAKENHI-PROJECT-23249015, KAKENHI-PLANNED-24118003, KAKENHI-PUBLICLY-24116711, KAKENHI-ORGANIZER-24118001
  • [Journal Article] Mammalian Polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate Polycomb activity both at the Hox gene cluster and at Cdkn2a genes2011

    • Author(s)
      Li X, Isono K et al.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 351-364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Journal Article] Mammalian polyhomeotic homologues Phc2 and Phcl act in synergy to mediate polycomb repression of Hox genes.2006

    • Author(s)
      Isono, K.
    • Journal Title

      Mol. Cell. Biol. 26

      Pages: 2758-2771

    • Data Source
      KAKENHI-PROJECT-18055037
  • [Journal Article] Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.2006

    • Author(s)
      Isono, K.
    • Journal Title

      Mol.Cell.Biol. 26

      Pages: 2758-2771

    • Data Source
      KAKENHI-PROJECT-18570189
  • [Journal Article] Mammalian Polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b12005

    • Author(s)
      Kyoichi Isono
    • Journal Title

      Genes & Development 19・5(印刷中)

    • Data Source
      KAKENHI-PROJECT-16022210
  • [Journal Article] Mammalian Polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b12005

    • Author(s)
      Kyoichi Isono
    • Journal Title

      Genes & Development 19・5(印刷中)

    • Data Source
      KAKENHI-PROJECT-15790144
  • [Presentation] クロマチン作用因子ポリコーム群複合体のDNA修復機能による癌抑制2021

    • Author(s)
      磯野協一、木村弥生、公文麻美、遠藤高帆、古関明彦
    • Organizer
      第44回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-19K06695
  • [Presentation] DNA損傷応答キナーゼATMからポリコーム群PHC2へのシグナル伝達は転写抑制機能とは独立してDNA修復に働く2019

    • Author(s)
      磯野協一
    • Organizer
      エピジェネティクス研究会
    • Data Source
      KAKENHI-PROJECT-19K06695
  • [Presentation] DNA損傷応答おけるポリコーム群PHC2リン酸化の役割2016

    • Author(s)
      磯野協一
    • Organizer
      エピジェネティクス研究会
    • Place of Presentation
      千里ライスサイエンスセンター
    • Data Source
      KAKENHI-PROJECT-26460379
  • [Presentation] ATMキナーゼによるポリコーム群PHC2リン酸化の役割2015

    • Author(s)
      磯野協一
    • Organizer
      第23回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      静岡県焼津市焼津グランドホテル
    • Year and Date
      2015-10-19
    • Data Source
      KAKENHI-PROJECT-26460379
  • [Presentation] 遺伝毒性ストレスによって誘導されるポリコーム群リン酸化のDNA修復への関与2015

    • Author(s)
      磯野協一
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市神戸ポートアイランド
    • Year and Date
      2015-12-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460379
  • [Presentation] ポリコーム群Phc2リン酸化による遺伝子サイレンシング2013

    • Author(s)
      磯野協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Presentation] ポリコーム群Phc2リン酸化による遺伝子サイレンシング2013

    • Author(s)
      磯野協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2013-12-05
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Presentation] 遺伝子サイレンシングにおけるポリコーム群Phc2リン酸化の役割2013

    • Author(s)
      磯野協一
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      奈良県新公会堂
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Presentation] 遺伝子サイレンシングにおけるポリコーム群Phc2リン酸化の役割2013

    • Author(s)
      磯野協一
    • Organizer
      エピジェネティクス研究会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2013-05-30
    • Data Source
      KAKENHI-PROJECT-25670152
  • [Presentation] 遺伝子サイレンシングにおけるポリコーム群Phc2リン酸化の役割2012

    • Author(s)
      磯野協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      博多
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] Gene silencing by the in vivo dynamics of Polycomb repressive complex PRC12012

    • Author(s)
      磯野協一
    • Organizer
      Mouse Molecular Genetics Conference
    • Place of Presentation
      Pacific Grove, USA
    • Year and Date
      2012-10-04
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] Roles of Phc2 polymerization in Polycomb repressive functions2012

    • Author(s)
      磯野協一
    • Organizer
      International Society for Stem Cell Research
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-15
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] Gene silencing by the dynamics of Polycomb-group protein complexes2011

    • Author(s)
      磯野協一
    • Organizer
      日本発生生物学会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] GENE SILENCING BY THE DYNAMICS OF POLYCOMB-GROUP PROTEIN COMPLEXES2011

    • Author(s)
      磯野協一
    • Organizer
      第4回日本発生生物学会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] 生細胞イメージングに最も適した材料はマウス遺伝子工学によって得られる2010

    • Author(s)
      磯野協一
    • Organizer
      日本遺伝学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] Gene silencing by an intrinsic inter-assembly of Polycomb-group protein complexes2010

    • Author(s)
      磯野協一
    • Organizer
      Cold Spring Harbor Asia Conference
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-05-18
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] Mechanisms of repressive chromatin condensations by Polycomb-group proteins2010

    • Author(s)
      磯野協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590278
  • [Presentation] Gene silencing by the dynamics of in vivo Polycomb-group protein complexes2009

    • Author(s)
      磯野協一
    • Organizer
      第24回内藤カンファレンス
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-24
    • Data Source
      KAKENHI-PROJECT-20052031
  • [Presentation] Gene silencing by the dynamics of Polycomb-group protein complexes2009

    • Author(s)
      磯野協一
    • Organizer
      Mouse Genetics & Genomics : Development & Disease
    • Place of Presentation
      Hinxton, UK
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-20052031
  • [Presentation] Relationships between the dynamics of Polycomb group complex and its repressive functions2009

    • Author(s)
      磯野協一
    • Organizer
      第32回分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-20052031
  • [Presentation] ポリコーム群複合体重合に伴う遺伝子サイレンシング2009

    • Author(s)
      磯野協一
    • Organizer
      第3回エピジェネティクス研究会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-20052031
  • [Presentation] ポリコーム群複合体ダイナミクスによる遺伝子抑制2008

    • Author(s)
      磯野協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20052031
  • [Presentation] ポリコーム群複合体ダイナミクスによる遺伝子抑制2008

    • Author(s)
      磯野協一
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      三島
    • Year and Date
      2008-05-09
    • Data Source
      KAKENHI-PROJECT-20052031
  • [Presentation] Evidence for hyper-dynamics of Polycomb repressive complexes by quantitative imaging and high-speed imaging2007

    • Author(s)
      磯野,協一
    • Organizer
      第40回日本発生生物学会年会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18570189
  • [Presentation] What do Polycomb proteins form huge complexes for?2007

    • Author(s)
      磯野,協一
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18570189
  • [Presentation] Evidence for hyper-dynamics of Polycomb repressive complexes by quantitative imaging and high-speed imaging2007

    • Author(s)
      Isono, K
    • Organizer
      The 40th annual meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18570189
  • [Presentation] What do Polycomb proteins form huge complexes for?2007

    • Author(s)
      磯野 協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-18570189
  • [Presentation] What do Polycomb proteins form huge complexes for?2007

    • Author(s)
      磯野協一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-18055037
  • [Presentation] What do Polycomb proteins form huge complexes for?2007

    • Author(s)
      Isono, K
    • Organizer
      The 30th annual meeting of The Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18570189
  • [Presentation] Nuclear dynamics of Polycomb repressive complexes2006

    • Author(s)
      Isono, K
    • Organizer
      International symposium Functional Organization of the Nucleus
    • Place of Presentation
      Awaji
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18570189
  • [Presentation] A step toward understanding the Hox gene colinearity

    • Author(s)
      磯野協一
    • Organizer
      27th Annual Mouse Molecular Genetics Conference
    • Place of Presentation
      Pacific Grove, USA
    • Year and Date
      2014-09-29 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-26460379
  • 1.  森 千里 (90174375)
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  • 2.  長田 久夫 (30233505)
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  • 3.  外山 芳郎 (70009637)
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  • 4.  小宮山 正敏 (70175339)
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  • 5.  深田 秀樹 (00359598)
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  • 6.  原 寿郎 (40150445)
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  • 7.  足達 哲也 (60345014)
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  • 8.  高田 秀重 (70187970)
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  • 9.  古関 明彦 (40225446)
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