Takahashi Mikiko 高橋美樹子

… Alternative Names

高橋美樹子タカハシミキコ

TAKAHASHI Mikiko 高橋美樹子

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Researcher Number	90324938
Other IDs
Affiliation (Current)	2025: 帝京平成大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 帝京平成大学, 薬学部, 教授 2010 – 2015: 帝京平成大学, 薬学部, 教授 2007: 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 講師 2007: Kobe University, Biosignal Research Center, Assistant Professor 2005 – 2007: Kobe University, Biosignal Research Center, Lecturer, バイオシグナル研究センター, 講師 2001 – 2004: 神戸大学, バイオシグナル研究センター, 助手
Review Section/Research Field	Principal Investigator Cell biology / Cell biology / Biological pharmacy Except Principal Investigator Neurology / Basic Section 48040:Medical biochemistry-related / Functional biochemistry
Keywords	Principal Investigator 中心体 / コイルドコイル蛋白質 / 微小管 / phosphorylation / centrosome / microtubule / coiled-coil protein / membrane traffic / Golgi apparatus / リン酸化 … More / 小胞輸送 / ゴルジ体 / Microtubule / Calmodulin / γ-Tubulin / Microtubule Organizing Center (MTOC) / Centrosome / カルモジュリン / γ-チューブリン / 微小管形成中心(MTOC) / 複製ライセンシング / セパレース / 分裂期 / 中心体複製 / 細胞周期 … More Except Principal Investigator 蛋白脱リン酸化酵素 / 蛋白リン酸化酵素 / タウ蛋白 / 細胞内シグナル伝達 / 認知症 / CG-NAP / 神経細胞変性 / ゴルジ体 / 中心体 / PKN / Signal transduction / Protein kinase / Tau / Alzheimer disease / Dementia / アルツハイマー病 / 国際情報交換（カナダ） / 一次繊毛形成 / ゴルジ微小管 / AKAP450 / 中心小体サテライト / 一次繊毛 / Degeneration / Neuron / Protein / 変性 / 神経細胞 / Golgi apparatus / centrosome / anchoring proteins / Protein kinases / アンカリング蛋白質 / 蛋白質リン酸化酵素 / Gene mutation / Protein phosphatase / Neuronal death / 蛋白合成 / 細胞内ジグナル伝達 / 遺伝子異常 / 神経細胞死 / 細胞周期 / 免疫組織化学 / 脳 / リン酸化 / 細胞周期調節 / タウ / 神経原線維変化 / 前頭側頭葉変性症 / アルツハイマー型認知症 / 国際情報交流（カナダ） / 脳神経疾患 / 神経科学 / シグナル伝達 / 痴呆 Less

CG-NAP function in ciliogenesis through regulation of centriolar satellite formation
- Principal Investigator
  
  Kim Honsong
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Teikyo Heisei University
タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析
- Principal Investigator
  
  川又敏男
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Functional analysis of separase and its novel substrate in the licensing of centrosome duplicationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Mikiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo Heisei University
タウ蛋白とリン酸化酵素複合体の相互作用を介した認知症脳神経細胞死の病態解析
- Principal Investigator
  
  川又敏男
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Pathological study for a protein anchoring tau kinases and tau phosphatases in Alzheimer brain tissues
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Research of signal transduction to neuronal degeneration mediated by tau-kinases complex in dementia
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Functional regulation of centrosome and Golgi apparatus by signal-anchoring proteins.
- Principal Investigator
  
  ONO Yoshitaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Research of signal transduction to neuronal degeneration mediated by tau phorphorylation in dementia
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Functional Analysis of an Anchoring Protein CG-NAP in the Golgi Apparatus.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Mikiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kobe University
Functional Analysis of an Anchoring Protein CG-NAP in the CentrosomePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Mikiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Biosignal Research Center, Kobe University

All 2019 2013 2012 2011 2010 2009 2008 2007 2003 Other

All Journal Article Presentation Book

[Book] Pulse-chase analysis of protein kinase C, in Methods in Molecular Biology, vol.233(PROTEIN KINASE C PROTOCOLS edited by Newton. A.)2003
- Author(s)
  Takahashi, M.
- Publisher
  Humana Press Inc. Totowa, NJ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570159
[Journal Article] More isn’t always better: Limiting centrosome size in interphase.　(News & Views)2013
- Author(s)
  ① Mikiko Takahashi and Kazuhiko Matsuo
- Journal Title
  
  Cell Cycle
  
  Volume: １２ Issue: 6 Pages: 1482-1482
- DOI
  10.4161/cc.23879
- Data Source
  KAKENHI-PROJECT-23590087
[Journal Article] Kendrin is a novel substrate for separate involved in the licensing of centriole duplication.2012
- Author(s)
  Matsuo, K., Ohsumi, K., Iwabuchi, M., Kawamata, T., Ono, Y., Takahashi, M.
- Journal Title
  
  Curr. Biol.
  
  Volume: 22 Issue: 10 Pages: 915-921
- DOI
  10.1016/j.cub.2012.03.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370091, KAKENHI-PROJECT-23590087, KAKENHI-PROJECT-23591276, KAKENHI-PUBLICLY-23114705
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles2010
- Author(s)
  Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, Akiyama H, Kawamata T
- Journal Title
  
  Neuroscience Letters
  
  Volume: 471 Pages: 20-24
- NAID
  120003290064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles2010
- Author(s)
  Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, Akiyama H, Kawamata T
- Journal Title
  
  Neuroscience Letters 471
  
  Pages: 20-24
- NAID
  120003290064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles.2010
- Author(s)
  Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, Akiyama H, Kawamata T.
- Journal Title
  
  Neuroscience Letters 471
  
  Pages: 20-24
- NAID
  120003290064
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.2009
- Author(s)
  Sugata H, Matsuo K, Nakagawa T, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T.
- Journal Title
  
  Neuroscience Letters 459
  
  Pages: 96-99
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] A peptidyl-proryl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles2009
- Author(s)
  Sugata H, Matsuo K, Nakagawa T, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T
- Journal Title
  
  Neuroscience Letters 459
  
  Pages: 96-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Pulse-chase analysis of protein kinase C (PROTEIN KINASE C PROTOCOLS edited by Newton, A.)2003
- Author(s)
  Takahashi, M., Ono, Y.
- Journal Title
  
  Methods in Molecular Biology(Humana Press Inc, Totowa, NJ,) vol.233
  
  Pages: 163-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570159
[Presentation] CG-NAP/AKAP450はPCM1の細胞内局在を制御することで一次繊毛形成に寄与する2019
- Author(s)
  金憲誠、会田紗也加、赤江亮祐、石原賢、鷺飛鳥、鈴木捺美、高橋美樹子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07356
[Presentation] Association of neuronal polypyrimidine tract binding protein with neurofibrillary tangles in Alzheimer brain tissues2013
- Author(s)
  Ito Y, Pan H-Y, Sonoda Y, Mukai H, Takahashi M, Maeda K, Akiyama H, Yoshimura N, Kawamata T
- Organizer
  The 43rd annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23591276
[Presentation] Serine/threonine-protein kinase CHK1 associates with Alzheimer neurofibrillary tangles2013
- Author(s)
  Pan H-Y, Sonoda Y, Mukai H, Takahashi M, Maeda K, Yasuhara O, Akiyama H, Kawamata T
- Organizer
  The 43rd annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23591276
[Presentation] Functional analysis of centrosomal protein kendrin in centriole duplication.2013
- Author(s)
  松尾和彦・高橋美樹子
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590087
[Presentation] p70 S6 kinase accumulates in neuronal inclusion bodies in Alzheimer brain tissues2012
- Author(s)
  Sonoda Y, Edatsugi S, Mukai H, Takahashi M, Ono Y, Akiyama H, Maeda K, Kawamata T
- Organizer
  Annual Meeting of Society for Neuroscience 2012
- Place of Presentation
  New Orleans (USA)
- Data Source
  KAKENHI-PROJECT-23591276
[Presentation] Possible role of a novel substrate for separase in the licensing of centriole duplication2011
- Author(s)
  高橋美樹子
- Organizer
  第34回分子生物学会年会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23590087
[Presentation] Association of protein kinase C delta with neurofibrillary tangles in Alzheimer brain tissues.2010
- Author(s)
  Sonoda Y, Matsuo K, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] Tumor suppressor PTEN is associated with neurofibrillary tangles in Alzheimer brain tissues.2009
- Author(s)
  Sonoda Y, Matsuo K, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] FKBP12 is associated with neurofibrillary tangles in Alzheimer brain tissues.2008
- Author(s)
  菅田陽怜, 松尾和彦, 高橋美樹子, 向井秀幸, 小野功貴, 前田潔, 川又敏男
- Organizer
  38^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] アルツハイマー病におけるPDK1活性化の検討2008
- Author(s)
  中川泰介、菅田陽怜、松尾和彦、高橋美樹子、向井秀幸、小野功貴、前田潔、秋山治彦、川又敏男
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] Function of CG-NAP in ribbon formation of Golgi apparatus2007
- Author(s)
  Takahashi, M
- Organizer
  BMB2007
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17370049
[Presentation] ゴルジ体リボン形成におけるアンカリング蛋白質CG-NAP(AKAP350/450)の機能について2007
- Author(s)
  高橋美樹子
- Organizer
  BMB2007
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17370049
[Presentation] Possible role of a novel substrate for separase in the licensing of centriole duplication
- Author(s)
  Matsuo, K. and Ono, Y., ○Takahashi, M.
- Organizer
  第34回分子生物学会年会シンポジウム(招待講演)
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23590087
[Presentation] 中心体複製制御機構におけるseparaseの新規基質候補蛋白質の解析
- Author(s)
  ○松尾和彦、小野功貴、高橋美樹子
- Organizer
  第34回分子生物学会年会ポスター
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23590087

1. MUKAI Hideyuki (80252758)

# of Collaborated Projects: 7 results

# of Collaborated Products: 12 results
2. KAWAMATA Toshio (70214690)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
3. ONO Yoshitaka (10243297)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
4. MAEDA Kiyoshi (80116251)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
5. MATSUO Kazuhiko (70599753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. TADA Shusuke (00216970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kim Honsong (70469899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 秋山治彦 (20231839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岩渕万里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 大隈圭太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Mikiko 高橋 美樹子

高橋 美樹子 タカハシ ミキコ

TAKAHASHI Mikiko 高橋 美樹子

Research Projects

Research Products

Co-Researchers

CG-NAP function in ciliogenesis through regulation of centriolar satellite formation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of separase and its novel substrate in the licensing of centrosome duplicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

タウ蛋白とリン酸化酵素複合体の相互作用を介した認知症脳神経細胞死の病態解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathological study for a protein anchoring tau kinases and tau phosphatases in Alzheimer brain tissues

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of signal transduction to neuronal degeneration mediated by tau-kinases complex in dementia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional regulation of centrosome and Golgi apparatus by signal-anchoring proteins.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of signal transduction to neuronal degeneration mediated by tau phorphorylation in dementia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Analysis of an Anchoring Protein CG-NAP in the Golgi Apparatus.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Analysis of an Anchoring Protein CG-NAP in the CentrosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Pulse-chase analysis of protein kinase C, in Methods in Molecular Biology, vol.233(PROTEIN KINASE C PROTOCOLS edited by Newton. A.)2003

Author(s)

Publisher

Description

Data Source

[Journal Article] More isn’t always better: Limiting centrosome size in interphase. (News & Views)2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kendrin is a novel substrate for separate involved in the licensing of centriole duplication.2012

Author(s)

Journal Title

DOI

Takahashi Mikiko 高橋美樹子

高橋美樹子タカハシミキコ

TAKAHASHI Mikiko 高橋美樹子

[Journal Article] More isn’t always better: Limiting centrosome size in interphase.　(News & Views)2013