Seno Hiroshi 妹尾浩

… Alternative Names

SENO Hiroshi 妹尾浩

妹尾浩セノオヒロシ

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Researcher Number	90335266
Other IDs
Affiliation (Current)	2022: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2015 – 2022: 京都大学, 医学研究科, 教授 2016: 京都大学, 大学院医学研究科, 教授 2015 – 2016: 京都大学, 医学(系)研究科(研究院), 教授 2011 – 2014: 京都大学, 医学(系)研究科(研究院), 講師 2013: 京都大学, 医学研究科, 講師 … More 2013: 京都大学, 大学院医学研究科, 講師 2008 – 2010: Kyoto University, 医学研究科, 講師 2002 – 2004: 京都大学, 医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Medium-sized Section 53:Organ-based internal medicine and related fields / Gastroenterology / Biological Sciences / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Pathological medical chemistry / General pharmacology / Basic Section 54020:Connective tissue disease and allergy-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 癌 / 大腸 / 大腸癌 / 炎症 / マウス / 分化 / マクロファージ / 腫瘍 / 膵臓 / IL-6 … More / Gas6 / 胃癌 / 腸上皮化生 / ホメオボックス遺伝子 / CDX2 / CDX1 / M2 / 内視鏡 / ApcMin / 腸 / 腸炎 / 自然免疫 / シェディング / 転写 / 幹細胞 / 消化器 / 胃 / β-カテニン / 発癌 / 間質 / サイトカイン / β一カテニン / 上皮・間質相互作用 / Th-1 / COX-2 / colon / β-catenin / inflammation / tumorigenesis / stroma / cytokine / 膵臓癌 / 可塑性 / 内科 / 難治がん / がん / 大腸がん / 膵がん … More Except Principal Investigator マクロファージ / 慢性炎症 / 癌幹細胞 / 大腸癌 / 膵癌 / マウスモデル / クロマチンリモデリング / Musashi-1 / 小腸幹細胞 / Hes-1 / パネート細胞 / 分子病態学 / 細胞内シグナル伝達 / シグナル伝達 / 組織幹細胞 / Hes1 / Dckl1 / 大腸ポリープ / 癌幹細胞治療 / 分子標的治療 / 膵臓がん / IPMN / 膵臓癌 / EPRAP / シグナル情報伝達 / 翻訳後修飾 / シグナル情報伝達系 / IgG4関連疾患 / 自己抗原 / 自己抗体 / 治療 / 膵がん / エピジェネティクス / バイオマーカー / 消化器がん / 臨床ヒト試料 / 時空間ダイナミクス / オルガノイド / 大腸がん / 網羅的ゲノム解析 / クローン進化 / ドライバー遺伝子 / バイオインフォマティクス / クローン拡大 / 自然選択 / 癌免疫療法 Less

ハイブリッド療法による大腸がん治療抵抗性メカニズムの克服
- Principal Investigator
  
  中西祐貴
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
超初期段階から引き返す膵発がん予防戦略の探求Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kyoto University
Physical Biomarkers Based on Dynamics of Cancer Cells and Organoids
- Principal Investigator
  
  田中求
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyoto University
Deciphering colorectal carcinogenesis by the genomic analysis of colorectal epithelial cells
- Principal Investigator
  
  垣内伸之
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
分化の揺らぎを克服する新規大腸がん治療戦略の構築Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
指定難病「IgG4関連疾患」の自己抗原同定による病態解明と新しい診療体系の確立
- Principal Investigator
  
  児玉裕三
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
Live imaging of human pancreatic cancer stem cell dynamicsPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kyoto University
浸潤性膵癌形成後の維持・進行におけるクロマチン制御因子の機能とその分子機構の解明
- Principal Investigator
  
  福田晃久
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Therapeutic strategy against gastrointestinal cancer by utilizing cancer hierarchyPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Nrd1 as a novel therapeutic target against colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Anti-cancer therapies baesd on novel cancer stem cell-specific factorsPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Role of EPRAP on the pathophysiology of chronic inflammatory diseases
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
がん微小環境における細胞外シェディングと核内転写の一元的制御Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
The functional role of chromatin remodeling regualtor Brg1 in pancreatic cancer
- Principal Investigator
  
  Fukuda Akihisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Identification of specific markers for cancer stem cells and anti-cancer therapy targeting cancer stem cells
- Principal Investigator
  
  CHIBA Tsutomu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Role of EP4 receptor-associated protein in regulating macrophage activation
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Inhibitory role of Gas6-mediated innate immunity in intestinal tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SENO Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Prevention and treatment of colorectal cancer by regulating macrophage activation.Principal Investigator
- Principal Investigator
  
  SENO Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Identification of novel stromal factors that regulate β-catenin localization in colorectal cancer --Prevention of invasion and metastasis in colorectal cancer--Principal Investigator
- Principal Investigator
  
  NABESHIMA Motoshige, 妹尾浩
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KINKI UNIVERSITY
  Kyoto University
小腸幹細胞の同定とその維持・分化に関わるRNA結合蛋白Musashi-1の解析
- Principal Investigator
  
  澤田光孝
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
ホメオボックス遺伝子CDX1,2が胃癌の悪性度に及ぼす影響についての検討Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University

[Book] Proton pump inhibitors and gastrointestinal side effects. Proton Pump Inhibitors : A Balanced View. Front Gastrointest Res. Vol.322013
- Author(s)
  Nakamura S, Seno H, Chiba T (Chiba T, Malfertheiner P, Satoh H (eds))
- Publisher
  Basel, Karger
- Data Source
  KAKENHI-PROJECT-23590937
[Book] pylori infection-The route from inflammation to cancer. Sansonetti P, ed, Infection Biology Handbook Series.Bacterial Virulence. Basic principles, models and global approaches.2010
- Author(s)
  Chiba T, Marusawa H, Seno H, Watanabe N.H.
- Publisher
  Willey-Blackwell
- Data Source
  KAKENHI-PROJECT-20599008
[Book] Bacterial Virulence. Basic principles, models and global approaches.2010
- Author(s)
  Chiba T, Seno H, et al.
- Total Pages
  11
- Publisher
  Willey-Blackwell
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging.2021
- Author(s)
  Maruno Takahisa、Fukuda Akihisa、Goto Norihiro、Tsuda Motoyuki、Ikuta Kozo、Hiramatsu Yukiko、Ogawa Satoshi、Nakanishi Yuki、Yamaga Yuichi、Yoshioka Takuto、Takaori Kyoichi、Uemoto Shinji、Saur Dieter、Chiba Tsutomu、Seno Hiroshi
- Journal Title
  
  Elife
  
  Volume: 10 Pages: 1-24
- DOI
  10.7554/elife.55117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22841, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-18J01600, KAKENHI-PROJECT-19K22619
[Journal Article] The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma.2021
- Author(s)
  2.Motoyuki Tsuda, Akihisa Fukuda, Munenori Kawai, Osamu Araki, Hiroshi Seno.
- Journal Title
  
  Cancer Sci
  
  Volume: 112 Pages: 490-497
- DOI
  10.1111/cas.14768
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-19K22619
[Journal Article] Hes1 is essential in proliferating ductal cell-mediated development of intrahepatic cholangiocarcinoma.2020
- Author(s)
  Matsumori T, Kodama Y, Takai A, Shiokawa M, Nishikawa Y, Matsumoto T, Takeda H, Marui S, Okada H, Hirano T, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Marusawa H, Kageyama R, Chiba T, Seno H.
- Journal Title
  
  Cancer Res
  
  Volume: 80 Pages: 5305-5316
- DOI
  10.1158/0008-5472.can-20-1161
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Short educational video to improve the accuracy of colorectal polyp size estimation: Multicenter prospective study.2020
- Author(s)
  Utsumi T, Horimatsu T, Nishikawa Y, Teramoto A, Hirata D, Iwatate M, Sano Y, Seno H.
- Journal Title
  
  Dig Endosc
  
  Volume: 32 Pages: 1074-1081
- DOI
  10.1111/den.13638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.2020
- Author(s)
  Kakiuchi Nobuyuki et al.
- Journal Title
  
  Nature.
  
  Volume: 577 Pages: 260-265
- DOI
  10.1038/s41586-019-1856-1
- NAID
  120006777064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K15747, KAKENHI-PROJECT-18K16084, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-19H04806, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-19H03560, KAKENHI-PROJECT-17J05245, KAKENHI-PROJECT-15H05707, KAKENHI-PROJECT-18H05278
[Journal Article] Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors.2020
- Author(s)
  Yamauchi Yuki、Kodama Yuzo、Uza Norimitsu、Masuda Atsuhiro、Tatsuoka Hisato、Masui Toshihiko、Inagaki Nobuya、Uemoto Shinji、Chiba Tsutomu、Seno Hiroshi
- Journal Title
  
  Cancer Res
  
  Volume: 80 Pages: 3620-3630
- DOI
  10.1158/0008-5472.can-19-2232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08677, KAKENHI-PROJECT-20K21616, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] SETDB1 Inhibits p53-Mediated Apoptosis and is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.2020
- Author(s)
  6.Ogawa S, Fukuda A, Matsumoto Y, Hanyu Yu, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T, Goto N, Hiramatsu Y, Tsuda M, Maruno T, Nakanishii Y, Hussein S.M, Tsuruyama T, Takaori K, Uemotoio　S, Seno H.
- Journal Title
  
  Gastroenterology
  
  Volume: 159 Pages: 682-696
- DOI
  10.1053/j.gastro.2020.04.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-18J01600, KAKENHI-PROJECT-19K22619
[Journal Article] CXCR4 in tumor epithelial cells mediates desmoplastic reaction in pancreatic ductal adenocarcinoma.2020
- Author(s)
  Morita, T., Kodama, Y., Shiokawa, M., Kuriyama, K., Marui, S., Kuwada, T., Sogabe, Y., Matsumori, T., Kakiuchi, N., Tomono, T., Mima, A., Ueda, T., Tsuda, M., Yamauchi, Y., Nishikawa, Y., Sakuma, Y., Ota, Y., Maruno, T., Uza, N., Nagasawa, T., Chiba, T., and Seno, H.
- Journal Title
  
  Cancer Res
  
  Volume: 80 Pages: 4058-4070
- DOI
  10.1158/0008-5472.can-19-2745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03998, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Epithelial EP4 plays an essential role in maintaining homeostasis in colon2019
- Author(s)
  Matsumoto Y, Nakanishi Y, Yoshioka T, Yamaga Y, Masuda T, Fukunaga Y, Sono M, Yoshikawa T, Nagao M, Araki O, Ogawa S, Goto N, Hiramatsu Y, Breyer RM, Fukuda A, Seno H.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 15244-15244
- DOI
  10.1038/s41598-019-51639-2
- NAID
  120006956728
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-17H04157
[Journal Article] Bmi1 marks gastric stem cells located in the isthmus in mice2019
- Author(s)
  Yoshioka T, Fukuda A, Araki O, Ogawa S, Hanyu Y, Matsumoto Y, Yamaga Y, Nakanishi Y, Kawada K, Sakai Y, Chiba T, Seno H.
- Journal Title
  
  The Journal of Pathology
  
  Volume: 248 Pages: 179-190
- DOI
  10.1002/path.5244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-17H04157
[Journal Article] Arid1a is essential for intestinal stem cells through Sox9 regulation2019
- Author(s)
  Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 116 (5) Pages: 1704-1713
- DOI
  10.1073/pnas.1804858116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-17H04059, KAKENHI-PROJECT-17H04157
[Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.2019
- Author(s)
  Nishikawa Y、Kodama Y、Shiokawa M、Matsumori T、Marui S、Kuriyama K、Kuwada T、Sogabe Y、Kakiuchi N、Tomono T、Mima A、Morita T、Ueda T、Tsuda M、Yamauchi Y、Sakuma Y、Ota Y、Maruno T、Uza N、Uesugi M、Kageyama R、Chiba T、Seno H
- Journal Title
  
  Oncogene.
  
  Volume: in press Pages: 4283-4296
- DOI
  10.1038/s41388-019-0718-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-17H06803, KAKENHI-PROJECT-16K09395, KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-18K16149, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-26220206
[Journal Article] Lineage tracing and targeting of IL17RB(+) tuft cell-like human colorectal cancer stem cells2019
- Author(s)
  Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Pages: 12996-13005
- DOI
  10.1073/pnas.1900251116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-18J01600
[Journal Article] Gene expression profile of Dclk1+ cells in intestinal tumors.2018
- Author(s)
  Yamaga Y, Fukuda A, Nakanishi Y, Goto N, Matsumoto Y, Yoshioka T, Maruno T, Chiba T, Seno H.
- Journal Title
  
  Dig Liver Dis.
  
  Volume: 50 Pages: 1353-1361
- DOI
  10.1016/j.dld.2018.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04157
[Journal Article] Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.2018
- Author(s)
  Sakuma Y, Kodama Y, Eguchi T, Uza N, Tsuji Y, Shiokawa M, Maruno T, Kuriyama K, Nishikawa Y, Yamauchi Y, Tsuda M, Ueda T, Matsumori T, Morita T, Tomono T, Kakiuchi N, Mima A, Sogabe Y, Marui S, Kuwada T, Okada A, Watanabe T, Nakase H, Chiba T, Seno H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Pages: 8829-8829
- DOI
  10.1038/s41598-018-27200-y
- NAID
  120006532078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04157
[Journal Article] Updated Trends in Gallbladder and Other Biliary Tract Cancers Worldwide2018
- Author(s)
  Matsumoto Tomonori、Seno Hiroshi
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: 16 Pages: 339-340
- DOI
  10.1016/j.cgh.2017.11.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15427
[Journal Article] The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis2018
- Author(s)
  Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Pages: 3475-3489
- DOI
  10.1172/jci94287
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-17H06805, KAKENHI-PROJECT-16K09394, KAKENHI-PROJECT-16K15613
[Journal Article] ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.2018
- Author(s)
  Kimura Y, Fukuda A, Ogawa S, Maruno T, Takada Y, Tsuda M, Hiramatsu Y, Araki O, Nagao M, Yoshikawa T, Ikuta K, Yoshioka T, Wang Z, Akiyama H, Wright CV, Takaori K, Uemoto S, Chiba T, Seno H.
- Journal Title
  
  Gastroenterology.
  
  Volume: 印刷中 Pages: 194-209
- DOI
  10.1053/j.gastro.2018.03.039
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J05511, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-16K09394
[Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.2018
- Author(s)
  Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, Nishi E, Seno H.
- Journal Title
  
  JCI insight
  
  Volume: 3 Issue: 8 Pages: 1-15
- DOI
  10.1172/jci.insight.91316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09575, KAKENHI-PROJECT-16H05297, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-15J03212, KAKENHI-PROJECT-16K15216, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-18H04164
[Journal Article] Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease2018
- Author(s)
  Eso Yuji、Takai Atsushi、Taura Kojiro、Takahashi Ken、Ueda Yoshihide、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 印刷中 Pages: 1649-1658
- DOI
  10.1111/jgh.14130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-16K09357
[Journal Article] Tumor invasion to the arteries feeding the gallbladder as a novel risk factor for cholecystitis after metallic stent placement in distal malignant biliary obstruction2017
- Author(s)
  Sogabe Yuko、Kodama Yuzo、Honjo Hajime、Aoyama Ikuo、Kawanami Chiharu, Seno Hiroshi, et al.
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 印刷中
- DOI
  10.1111/den.12991
- NAID
  130007569115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04157
[Journal Article] Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma2017
- Author(s)
  Matsumoto Tomonori、Takai Atsushi、Eso Yuji、Kinoshita Kazuo、Manabe Toshiaki、Seno Hiroshi、Chiba Tsutomu、Marusawa Hiroyuki
- Journal Title
  
  Cancer Research
  
  Volume: 77 Pages: 6131-6143
- DOI
  10.1158/0008-5472.can-17-1800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-17H04158, KAKENHI-PROJECT-16K15427
[Journal Article] Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors2017
- Author(s)
  Kou Tadayuki、Kanai Masashi、Yamamoto Yoshihiro、Kamada Mayumi、Nakatsui Masahiko、Sakuma Tomohiro、Mochizuki Hiroaki、Hiroshima Akinori、Sugiyama Aiko、Nakamura Eijiro、Miyake Hidehiko、Minamiguchi Sachiko、Takaori Kyoichi、Matsumoto Shigemi、Haga Hironori、Seno Hiroshi、Kosugi Shinji、Okuno Yasushi、Muto Manabu
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1440-1446
- DOI
  10.1111/cas.13265
- NAID
  120006333897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08646, KAKENHI-PROJECT-16K15427
[Journal Article] Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.2017
- Author(s)
  Basak O, Beumer J, Wiebrands K, Seno H, van Oudenaarden A, Clevers H.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 20 Pages: 177-190
- DOI
  10.1016/j.stem.2016.11.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma2017
- Author(s)
  Eso Yuji、Uza Norimitsu、Yamagishi Hiroko、Imada Kazuaki、Kimura Yuto、Masui Toshihiko、Kodama Yuzo、Seno Hiroshi
- Journal Title
  
  Medicine
  
  Volume: 96
- DOI
  10.1097/md.0000000000009217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157
[Journal Article] Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine2017
- Author(s)
  Goto Norihiro、Ueo Taro、Fukuda Akihisa、Kawada Kenji、Sakai Yoshiharu、Miyoshi Hiroyuki、Taketo Makoto Mark、Chiba Tsutomu、Seno Hiroshi
- Journal Title
  
  Cancer Research
  
  Volume: 77 Pages: 3442-3454
- DOI
  10.1158/0008-5472.can-16-3192
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-15J03212, KAKENHI-PROJECT-16K15427
[Journal Article] Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.2017
- Author(s)
  Kimura Y, Ikuta K, Kimura T, Chiba T, Oshima H, Oshima M, *Nishi E, *Seno H
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 43052-43052
- DOI
  10.1038/srep43052
- NAID
  120006355734
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293068, KAKENHI-PROJECT-26293173, KAKENHI-PROJECT-16K07111, KAKENHI-PROJECT-16K15216, KAKENHI-PROJECT-16K15427
[Journal Article] Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B2017
- Author(s)
  Matsumoto T, Takahashi K, Inuzuka T, Kim SK, Kurosaki T, Kawakami S, Chiba T, Seno H, Marusawa H.
- Journal Title
  
  Antiviral Res.
  
  Volume: 139 Pages: 138-145
- DOI
  10.1016/j.antiviral.2017.01.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J11897, KAKENHI-PROJECT-14J02212, KAKENHI-PROJECT-26293173
[Journal Article] Diagnostic performance of a new “endoscopic scraper” for malignant biliary strictures: A multicenter prospective study.2017
- Author(s)
  Sakuma Y, Kodama Y, Sogabe Y, Nakai Y, Yamashita Y, Mikami S, Kajimura K, Ikeda K, Tamaki H, Iwamoto S, Matsuda F, Fujita K, Uza N, Kawamura T, Uemoto S, Seno H, Chiba T, Yazumi S; Kyoto Pancreatobiliary Study Group.
- Journal Title
  
  Gastrointest Endosc
  
  Volume: 85 Pages: 371-379
- DOI
  10.1016/j.gie.2016.07.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.2016
- Author(s)
  Takada Y, Fukuda A, Chiba T, Seno H.
- Journal Title
  
  Development
  
  Volume: 143 Pages: 3532-3539
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.2016
- Author(s)
  Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
- Journal Title
  
  GUT
  
  Volume: 未定 Pages: 1322-1322
- DOI
  10.1136/gutjnl-2015-310336
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893123, KAKENHI-PROJECT-25461022, KAKENHI-PROJECT-26293173, KAKENHI-PROJECT-15K15290, KAKENHI-PROJECT-16K15427, KAKENHI-PROJECT-16K19339
[Journal Article] Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.2016
- Author(s)
  Takada Y, Fukuda A, Chiba T, Seno H.
- Journal Title
  
  Development
  
  Volume: 143 Pages: 3532-3539
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15427
[Journal Article] Endoscopic intraluminal cutting technique for indwelling devices using a lithotripter handle and guidewire.2015
- Author(s)
  Muta Y, Nishikawa Y, Watanabe K, Kawano K, Seno H, Chiba T, Yazumi S.
- Journal Title
  
  Endoscopy
  
  Volume: 47
- DOI
  10.1055/s-0034-1391836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] EP4 receptor-associated protein in macrophages ameliorates colitis and colitis-associated tumorigenesis.2015
- Author(s)
  Nakatsuji, M., M. Minami*, H. Seno*, M. Yasui, H. Komekado, S. Higuchi, R. Fujikawa, Y. Nakanishi, A. Fukuda, K. Kawada, Y. Sakai, T. Kita, P. Libby, H. Ikeuchi, M. Yokode, and T. Chiba
- Journal Title
  
  PLoS Genet.
  
  Volume: 11
- DOI
  10.1371/journal.pgen.1005542
- NAID
  120005947032
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-26293173
[Journal Article] Images of the Month: A polypoid lesion in the portal vein.2015
- Author(s)
  Hiramatsu Y, Ida H, Seno H.
- Journal Title
  
  Am J Gastroenterol.
  
  Volume: 110 Pages: 798-798
- DOI
  10.1038/ajg.2014.397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Breast cancer metastasis to the esophagus diagnosed using endoscopic ultrasound-guided fine-needle aspiration.2015
- Author(s)
  Matsumoto Y, Matsukawa H, Seno H, Ono S.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 30 Pages: 233-233
- DOI
  10.1111/jgh.12819
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112707, KAKENHI-PROJECT-26293173
[Journal Article] 細胞系譜解析による大腸腫瘍幹細胞特異的な因子の同定2015
- Author(s)
  妹尾浩、山賀雄一、中西祐貴、千葉勉
- Journal Title
  
  日本臨床
  
  Volume: 73 Pages: 850-854
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Deletion of nardilysin prevents tieh development of steatohepatitis and liver fibrotic changes2014
- Author(s)
  Ishizu-Higashi S, Seno H, Nishi E, Matsumoto Y, Ikuta K, Tsuda M, Kimura Y, Takada Y, Kimura Y, Nakanishi Y, Kanda K, Komekado H, Chiba T.
- Journal Title
  
  10.1371/journal.pone.0098017
  
  Volume: 9
- DOI
  10.1371/journal.pone.0098017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590914, KAKENHI-PROJECT-24659363, KAKENHI-PUBLICLY-25112707, KAKENHI-PUBLICLY-25130706, KAKENHI-PROJECT-25860533, KAKENHI-PUBLICLY-26116715, KAKENHI-PROJECT-26293068, KAKENHI-PROJECT-26293173, KAKENHI-PROJECT-26670139
[Journal Article] A case of acute necrotizing esophagitis.2014
- Author(s)
  Kimura Y, Seno H, Yamashita Y.
- Journal Title
  
  Gastrointest Endosc.
  
  Volume: 80 Pages: 525-526
- DOI
  10.1016/j.gie.2014.03.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Esophageal ulcer due to lymphoma.2014
- Author(s)
  Ikuta K, Umeda M, Seno H.
- Journal Title
  
  Intern Med.
  
  Volume: 53 Pages: 2649-2650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Molecular changes leading to gastric cancer: A suggestion from rare-type gastric tumors with GNAS mutations.2014
- Author(s)
  Ikuta K, Seno H, Chiba T.
- Journal Title
  
  Gastroenterology
  
  Volume: 146 Pages: 1417-1418
- DOI
  10.1053/j.gastro.2014.03.025
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112707, KAKENHI-PUBLICLY-25130706, KAKENHI-PROJECT-26293173
[Journal Article] Dclk1 distinguishes between tumor and normal stem cells in the intestine2013
- Author(s)
  Yuki Nakanishi, et. al.
- Journal Title
  
  Nature Genet
  
  Volume: 45 Pages: 98-103
- DOI
  10.1038/ng.2481
- NAID
  120004996279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-13J02261, KAKENHI-PROJECT-22370052, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-24590914, KAKENHI-PROJECT-24590916, KAKENHI-PROJECT-24657132, KAKENHI-PROJECT-24659363, KAKENHI-PUBLICLY-25130706
[Journal Article] Inhibitory role of Gas6 in intestinal tumorigenesis2013
- Author(s)
  Yuki Nakanishi, et. al.
- Journal Title
  
  Carcinogenesis
  
  Volume: (印刷中) Pages: 1567-1574
- DOI
  10.1093/carcin/bgt069
- NAID
  120005477205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-24659363, KAKENHI-PUBLICLY-25112707, KAKENHI-PUBLICLY-25130706
[Journal Article] The role of Hes genes in intestinal development, homeostasis and tumor formation2012
- Author(s)
  Ueo T, Imayoshi T, Kobayashi T, OhtsukaT, Seno H, Nakae H, Chiba T, Kageyama R
- Journal Title
  
  Developmant
  
  Volume: 139 Pages: 1071-1082
- DOI
  10.1242/dev.069070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-21240028, KAKENHI-PROJECT-22687017, KAKENHI-PROJECT-22790642, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-24590916, KAKENHI-PROJECT-24659363
[Journal Article] Nardilysin promotes gastric cancer cell growth by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-α2012
- Author(s)
  Kanda K, Komekado H, Kawada M, et al
- Journal Title
  
  EMBO Mol Med.
  
  Volume: (印刷中) Pages: 1-16
- DOI
  10.1002/emmm.201200216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J40033, KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-22790641, KAKENHI-PUBLICLY-23122510, KAKENHI-PROJECT-23300117, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-23659154, KAKENHI-PROJECT-23659755, KAKENHI-PROJECT-24590914, KAKENHI-PROJECT-24659363, KAKENHI-PROJECT-24700366, KAKENHI-PUBLICLY-23117519, KAKENHI-PUBLICLY-24113713
[Journal Article] COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+mouse polyps2011
- Author(s)
  Nakanishi Y, Seno H, Kawada M, et al
- Journal Title
  
  Carcinogenes
  
  Volume: 32(9) Pages: 1333-1339
- DOI
  10.1093/carcin/bgr128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J40033, KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-22790642, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937
[Journal Article] Indigenous Clostridium Species regulate systemic immune responses by induction of colonic regulatory T cells.2011
- Author(s)
  Chiba T, Seno H.
- Journal Title
  
  Gastroenterology
  
  Volume: 141 Pages: 1114-1116
- DOI
  10.1053/j.gastro.2011.07.013
- Data Source
  KAKENHI-PROJECT-23590937
[Journal Article] COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps.2011
- Author(s)
  Nakanishi, Y., M. Nakatsuji, H. Seno, S. Ishizu, R. Akitake-Kawano, K. Kanda, T. Ueo, H. Komekado, M. Kawada, M. Minami, T. Chiba.
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Pages: 1333-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Multiple sexually transmitted infections.2010
- Author(s)
  Nakanishi Y, Seno H, et al.
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 25 Pages: 843-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Metastatic gastrointestinal stromal cell tumor mimicking gastrointestinal polyposis.2010
- Author(s)
  Nakanishi Y, Kanda K, Akitake R, Seno H, Chiba T, Ono K, Kayahara T, Yamashita Y.
- Journal Title
  
  Endoscopy. 42 Suppl 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] 胃ではLgr5陽性細胞が自己再生をにない、さらにこの細胞からin vitroで胃腺窩を長期間構築できた2010
- Author(s)
  上尾太郎、妹尾浩、千葉勉
- Journal Title
  
  分子消化器病 7
  
  Pages: 185-187
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Multiple sexually transmitted infections.2010
- Author(s)
  Nakanishi Y, Seno H, Chiba T, Yamashita Y.
- Journal Title
  
  J Gastoroenterol Hepatol. 25(4)
  
  Pages: 843-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] ポリポーシス症候群の遺伝子異常はどこまで解明されたか2009
- Author(s)
  妹尾浩, ほか
- Journal Title
  
  分子消化器病 6
  
  Pages: 56-61
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Perivascular epithelioid cell tumor (PEComa) of the liver diagnosed by contrast-enhanced ultrasonography.2009
- Author(s)
  Akitake R, Kimura H, Sekoguchi S, Nakamura H, Seno H, Chiba T, Fujimoto S.
- Journal Title
  
  Intern Med. 48(24)
  
  Pages: 2083-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] ポリポーシス症候群の遺伝子異常はどこまで解明されたか2009
- Author(s)
  妹尾浩、中西祐貴、秋武玲子、千葉勉
- Journal Title
  
  分子消化器病 6
  
  Pages: 262-267
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Hypoxia induced by intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1 dependent pathway.2006
- Author(s)
  Uenoyama Y, Seno H, Chiba T, et al.
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006
- Author(s)
  Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara T, Chiba T
- Journal Title
  
  Cancer Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006
- Author(s)
  Kawada M, Seno H, Chiba T, et al.
- Journal Title
  
  Cancer Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Hypoxia induced by intestinal epithelial, cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1 dependent pathway.2006
- Author(s)
  Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 activation is involved in nuclear accumulation of b-cateninin colorectal cancer.2006
- Author(s)
  Kawada M, Seno H, Chiba T, et al.
- Journal Title
  
  Cancer Res (in press)
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Hypoxia induced by intestinal epithelial cells is associated with cyclooxynenase-2 expression in stromal cells through AP-1 dependent pathway.2006
- Author(s)
  Uenoyama Y, Seno H, Chiba T, et al.
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.2005
- Author(s)
  Suzuki K, Fukui H, Kayahara T, Sawada M, Seno H, Hiai H, Kageyama R, Okano H, Chiba T
- Journal Title
  
  Biochem Biophys Res Commun. 328
  
  Pages: 348-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.2005
- Author(s)
  Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, Seno H, Takasawa S, Okamoto H, Fujimori T, Chiba T
- Journal Title
  
  Gastroenterology 128
  
  Pages: 642-653
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Possible role of REG I{alpha} protein in ulcerative colitis and colitic cancer.2005
- Author(s)
  Sekikawa A, Fukui H, Fujii S, Nanakin A, Kanda N, Uenoyama Y, Sawabu T, Hisatsune H, Kusaka T, Ueno S, Nakase H, Seno H, Fujimori T, Chiba T
- Journal Title
  
  Gut 54
  
  Pages: 1437-1444
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004
- Author(s)
  Kanda N, Seno H, Konda Y, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, Sekikawa A, Kawada M, Suzuki K, Kayahara T, Fukui H, Sawada M, Marusawa H, Chiba T
- Journal Title
  
  Oncogene 23
  
  Pages: 4921-4929
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004
- Author(s)
  Kanda N, Seno H, Chiba T, et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 4921-4929
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫，幽門腺形質をもつBilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、妹尾浩
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Setdb1 deletion protects against formation of pancreatic ductal adenocarcinoma by inducing p53-mediated apoptosis.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Intestinal tumor stem cell specific ablation of Brg1 resulted in reduction of intestinal tumors with increased apoptosis.2020
- Author(s)
  Takaaki Yoshikawa, Akihisa Fukuda, Hiroshi Seno.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  51st Annual Meeting of the American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Brg1, a subunit of the SWI/SNF complex, is critical for growth and metastasis of pancreatic cancer cells in mice.2020
- Author(s)
  Osamu Araki, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  51st Annual Meeting of the American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Bmi1 is required for pancreatic cancer formation through regulating PI3K/AKT pathway in mice.2020
- Author(s)
  Sono Makoto, Fukuda Akihisa, Tsuda Motoyuki, Seno Hiroshi
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Setdb1 deletion protects against formation of pancreatic ductal adenocarcinoma by inducing p53-mediated apoptosis.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Brg1, a subunit of the SWI/SNF complex, is critical for growth and metastasis of pancreatic cancer cells in mice.2020
- Author(s)
  Osamu Araki, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Intestinal tumor stem cell specific ablation of Brg1 resulted in reduction of intestinal tumors with increased apoptosis.2020
- Author(s)
  Takaaki Yoshikawa, Akihisa Fukuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Bmi1 is required for pancreatic cancer formation through regulating PI3K/AKT pathway in mice.2020
- Author(s)
  Makoto Sono, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫，幽門腺形質をもつBilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、妹尾浩
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] 潰瘍性大腸炎における大腸上皮細胞のクローン進化と発がん2020
- Author(s)
  垣内伸之, 妹尾浩, 小川誠司
- Organizer
  第62回日本消化器病学会大会(JDDW2020)
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫BilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、尾松万悠紀、並川実桜、薗誠、福永裕一、益田朋典、荒木理、吉川貴章、小川智、平松由紀子、津田喬之、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫BilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、尾松万悠紀、並川実桜、薗誠、福永裕一、益田朋典、荒木理、吉川貴章、小川智、平松由紀子、津田喬之、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] The role of tuft cell-like tumor/cancer cells in intestinal tumors.2019
- Author(s)
  妹尾浩、後藤規弘、福田晃久
- Organizer
  第78回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The role of tuft cell-like tumor/cancer cells in intestinal tumors.2019
- Author(s)
  妹尾浩、後藤規弘、福田晃久
- Organizer
  第78回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Essential role of Arid1a in intestinal stem cell maintenance and homeostasis through Sox9 regulation.2018
- Author(s)
  Yukio Hiramatsu, Akihisa Fukuda, Hiroshi Seno
- Organizer
  GI Research Academy 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] 腸管の正常幹細胞と腫瘍幹細胞におけるHes1の役割2018
- Author(s)
  後藤規弘、福田晃久、妹尾浩
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The functional role of Eset in exocrine pancreatic regeneration and pancreatic cancer initiation2018
- Author(s)
  小川智、福田晃久、津田喬之、後藤規弘、平松由紀子、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] Sox9制御を介した腸幹細胞、腸恒常性維持におけるArid1aの役割について2018
- Author(s)
  平松由紀子、福田晃久、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.2018
- Author(s)
  津田喬之、福田晃久、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] 代謝、炎症、発癌を制御する因子Nardilysinの可能性2017
- Author(s)
  生田耕三、福田晃久、妹尾浩
- Organizer
  第103回日本消化器病学会総会内第1回消化器臓器間ネットワーク附置研究会
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] 膵がん形成過程における可塑性と幹細胞性2017
- Author(s)
  妹尾浩、丸野貴久、後藤規弘、津田喬之、木村佳人、福田晃久
- Organizer
  第76回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] BRG1はSox9の発現制御を介しPanINの形成・維持に重要な役割をはたす2017
- Author(s)
  津田喬之、福田晃久、妹尾
- Organizer
  JDDW 2017
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Brg1 plays a critical role in PanIN formation through regulating Sox9 expression.2017
- Author(s)
  Motoyuki Tsuda, Akihisa Fukuda, Takahisa Maruno, Haruhiko Akiyama, Kyoichi Takaori, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno, et al.
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] Nrdc inhibtits Kras-driven pancreatic tumorigenesis through suppressing spontaneous pancreatitis2017
- Author(s)
  Kozo Ikuta,Akihisa Fukuda,Tomoyuki Tsuda,Takahisa Maruno,Keitaro Kanda,Eiichiro Nishi,Hiroshi Seno
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Nardilysin functions as a tumor suppressor in pancreatic ductal adenocarcinoma through maintaining acinar cell differentiation and suppressing pancreatitis2017
- Author(s)
  Kozo Ikuta, Akihisa Fukuda, Hiroshi Seno
- Organizer
  JDDW 2017
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] EpCAM陽性肝幹/前駆細胞を起源とした肝発癌の分子機構2017
- Author(s)
  松本知訓、妹尾浩、丸澤宏之
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The role of Hes1 in the normal and tumor stem cells of the intestine.2017
- Author(s)
  Norihiro Goto, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The role of Hes1 in the normal and tumor stem cells of the intestine.2017
- Author(s)
  Norihiro Goto, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Nardilysin functions as a tumor suppressor in pancreatic ductal adenocarcinoma through maintaining acinar cell differentiation and suppressing pancreatitis.2017
- Author(s)
  Kozo Ikuta, Akihisa Fukuda, Eiichiro Nishi, Hiroshi Seno, et al.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] Brg1 plays an important role in acinar cell-derived PanIN formation through regulation of SOX9 expression.2016
- Author(s)
  Tsuda M, Fukuda A, Chiba T, Seno H.
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Cell of origin and tumor stem cells in mouse digestive organ tumors.2016
- Author(s)
  Seno H
- Organizer
  The 47th Princess Takamatsu Cancer Research Funf International Symposia
- Place of Presentation
  Tokyo, Palace Hotel Tokyo
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Hierarchy in mouse digestive organ tumors.2016
- Author(s)
  妹尾浩、丸野貴久、津田喬之、福田晃久
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] クロマチンリモデリング因子Ｂrg１はIＰＭＮおよびIPMN由来膵癌の発生を抑制する2016
- Author(s)
  Fukuda A, Chiba T, Seno H
- Organizer
  第20回分子標的治療学会学術集会
- Place of Presentation
  別府
- Year and Date
  2016-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-25461021
[Presentation] 消化器腫瘍における腫瘍幹細胞標的治療2016
- Author(s)
  妹尾浩、丸野貴久、後藤規弘、福田晃久
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Role of Dclk1-expressing cells in digestive organs.2016
- Author(s)
  Seno H, Maruno T, Fukuda A.
- Organizer
  The 41st Naito Conference
- Place of Presentation
  Sapporo, Chateraise Gateaux Kingdom
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 消化器腫瘍における腫瘍幹細胞標的治療2016
- Author(s)
  妹尾浩、丸野貴久、後藤規弘、福田晃久
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] 消化器臓器における腫瘍幹細胞の役割2015
- Author(s)
  妹尾浩
- Organizer
  第4回Cancer Stem Cell Symposium
- Place of Presentation
  福岡市
- Year and Date
  2015-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Microarray analysis of Dclk1-positive tumor cells in ApcMin/+ mouse polyps.2015
- Author(s)
  Yamaga Y, Seno H, Chiba T.
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 細胞系譜解析を用いた消化器腫瘍幹細胞の検討2015
- Author(s)
  妹尾浩
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Targeting tumor stem cells in the intestine.2015
- Author(s)
  Seno H, Yamaga Y, Matsumoto Y, Nakanishi Y, Fukuda A, Chiba T.
- Organizer
  The 3rd JSGE International Topic Conference
- Place of Presentation
  仙台市
- Year and Date
  2015-04-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Cell of origin and complexity in digestive organ tumors.2015
- Author(s)
  妹尾浩、福田晃久、丸野貴久、後藤規弘、千葉勉
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Tumor stem cells in digestive organs2015
- Author(s)
  Seno H
- Organizer
  2nd IFOM-Kyoto University Joint Symposium.
- Place of Presentation
  京都市
- Year and Date
  2015-10-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 消化器腫瘍モデルにおけるDCLK1陽性細胞の意義2015
- Author(s)
  妹尾浩
- Organizer
  平成26年度がん研究分野の特性等を踏まえた支援活動冬期公開シンポジウム
- Place of Presentation
  東京都千代田区
- Year and Date
  2015-01-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] The role of Dclk1-positive cells in digestive organ tumors.2014
- Author(s)
  Seno H
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都府京都市
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] The role of Dclk1-positive cells in digestive organ tumors.2014
- Author(s)
  Seno H
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都府京都市
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] Dclk1, a specific marker for tumor stem cells in digestive organs.2014
- Author(s)
  妹尾浩、中西祐貴、千葉勉
- Organizer
  第52回日本癌治療学会学術集会　高松宮妃癌研究基金共催国際シンポジウム
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Role of Dclk1-expressing cells in digestive organ tumors.2014
- Author(s)
  妹尾浩、丸野貴久、山賀雄一、吉岡拓人、中西祐貴、千葉勉
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 腸腫瘍幹細胞特異的マーカーDclk1の同定2013
- Author(s)
  中西祐貴、上尾太郎、妹尾浩
- Organizer
  International Sessionsがん幹細胞第72回日本癌学会総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Intestinal tumors are continuously renewed by Dclk1-positive tumor stem cells2013
- Author(s)
  Nakanishi Y, Seno H, Chiba T.
- Organizer
  American Association of Cancer Research, Annual Meeting 2013
- Place of Presentation
  Washington DC, USA, Walter E. Washington Convention Center
- Year and Date
  2013-04-10
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 正常腸管および腸腫瘍におけるDclk1/Lgr5陽性細胞の役割2013
- Author(s)
  中西祐貴, 妹尾浩, 上尾太郎
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島かごしま県民交流センター
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Nardilysin promotes gastric cancer growth by activating intrinsic cytokine signaling2013
- Author(s)
  Kanda K, Kimura Y, Yoshioka T, Seno H, Chiba T
- Organizer
  The 4th JCA-AACR Special Joint Conference
- Place of Presentation
  東京ベイ舞浜ホテル（千葉県浦安市）
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] 正常腸管および腸腫瘍におけるDclk1/Lgr5陽性細胞の役割2013
- Author(s)
  中西祐貴、妹尾浩、上尾太郎
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島かごしま県民交流センター
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine.シンポジウムがん幹細胞研究に基づく新たながん治療戦略2013
- Author(s)
  妹尾浩, 中西祐貴, 千葉勉
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸神戸国際会議場
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine2013
- Author(s)
  妹尾浩、中西祐貴、千葉勉
- Organizer
  シンポジウムがん幹細胞研究に基づく新たながん治療戦略第36回日本分子生物学会年会
- Place of Presentation
  神戸神戸国際会議場
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Intestinal tumors are continuously renewed by Dclk1-positive tumor stem cells2013
- Author(s)
  Nakanishi Y, Seno H, Chiba T
- Organizer
  American Association of Cancer Research, Annual Meeting 2013
- Place of Presentation
  Washington DC, USA, Walter E. Washington Convention Center
- Year and Date
  2013-04-10
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] 腸腫瘍幹細胞特異的マーカーDclk1の同定. International Sessionsがん幹細胞2013
- Author(s)
  中西祐貴, 上尾太郎, 妹尾浩
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Hes1は大腸上皮細胞の位置を規定し、ニッチ由来のWntやBMPシグナルによる分化制御に関与する2012
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 腸腫瘍幹細胞特異的マーカーDcamkl1の同定2012
- Author(s)
  中西祐貴, 上尾太郎, 妹尾浩
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine2012
- Author(s)
  Seno H
- Organizer
  GI Research Academy 2012
- Place of Presentation
  Tokyo, Japan, Keidanren Hall
- Year and Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Hes1は大腸上皮細胞の位置を規定し, ニッチ由来のWntやBMPシグナルによる分化制御に関与する2012
- Author(s)
  上尾太郎, 妹尾浩, 仲瀬裕志:
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] The role of Dclk1-positive cells in the intestinal homeostasis2012
- Author(s)
  Nakanishi Y, Seno H, Ueo T, Chiba T
- Organizer
  2012 James W. Freston Single Topic Conference : Gastrointestinal Stem Cell Biology and Pathobiology
- Place of Presentation
  Chicago, USA, Intercontinental Hotel Chicago
- Year and Date
  2012-08-27
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] The role of Dclk1-positive cells in the intestinal homeostasis. 2012 James W. Freston Single Topic Conference2012
- Author(s)
  Nakanishi Y, Seno H, Ueo T, Chiba T.
- Organizer
  Gastrointestinal Stem Cell Biology and Pathobiology
- Place of Presentation
  Chicago, USA, Intercontinental Hotel Chicago
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 腸腫瘍幹細胞特異的マーカーDcamkl1の同定2012
- Author(s)
  中西祐貴、上尾太郎、妹尾浩
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine2012
- Author(s)
  Seno H.
- Organizer
  GI Research Academy 2012
- Place of Presentation
  Tokyo, Japan, Keidanren Hall
- Year and Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] ナルディライジンはTNF-αのシェディングを促進し内因性サイトカインシグナル経路を活性化して胃癌細胞の増殖を制御する2011
- Author(s)
  神田啓太郎、米門秀行、妹尾浩、千葉勉、西英一郎
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Hes not only regulates the proliferation and differentiation of colon stem cell but also keep stem cells at correct position.2010
- Author(s)
  Ueo T, Seno H, Nakase H
- Organizer
  1st International Topic Conference.
- Place of Presentation
  Kamakura, Japan
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes not only regulates the proliferation and differentiation of colon stem cell but also keep stem cells at correct position.2010
- Author(s)
  Ueo T, Seno H, et al.
- Organizer
  International Topic Conference
- Place of Presentation
  Kamakura
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes1は大腸腫瘍の増殖や未分化性の維持に重要である2010
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes1は大腸腫瘍の増殖や未分化能の維持に重要である2010
- Author(s)
  上尾太郎, 妹尾浩, 他
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] ナルディライジンによるIL-6/Stat3シグナルを介した胃癌細胞の増殖制御2010
- Author(s)
  神田啓太郎、米門秀行、妹尾浩、千葉勉、西英一郎
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes1は、大腸上皮幹細胞の分化や増殖を制御し、さらに幹細胞の位置や陰窩の形態保持に関与している2010
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] 消化管上皮ならび腫瘍におけるHesの役割2009
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Efficient colonic mucosal wound repair requires Trem2-dependent alternative activation of macrophages.2009
- Author(s)
  Seno H.
- Organizer
  US-Japan GI Executive Meeting.
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] マウス内視鏡を用いた新規大腸粘膜障害・再生モデルの検討2009
- Author(s)
  秋武玲子、神田啓太郎、米門秀行、河田真由美、妹尾浩、千葉勉
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] The role of Nardilysin in intestinal tumorigenesis
- Author(s)
  Seno H, Kanda K, Nishi E, Chiba T
- Organizer
  GI Research Academy 2013
- Place of Presentation
  京都グランヴィアホテル（京都府京都市）
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] 腸腫瘍微小環境におけるナルディライジンの役割
- Author(s)
  妹尾　浩、神田啓太郎、千葉　勉
- Organizer
  平成25年度文部科学省新学術領域研究　がん研究分野の特性等を踏まえた支援活動　公開シンポジウム
- Place of Presentation
  一橋講堂(東京)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Identification of a pancreatic tumor specific stem cell marker.
- Author(s)
  Takahisa Maruno, Akihisa Fukuda, Hiroshi Seno, Tsutomu　Chiba.
- Organizer
  第73回日本癌学会学術総会 2014　東京.
- Place of Presentation
  東京
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25461021
[Presentation] Nardilysin promotes gastric cancer growth by activating intrinsic cytokine signaling
- Author(s)
  Keitaro Kanda, Yuto Kimura, Takuto Yoshioka, Hiroshi Seno, Tsutomu Chiba
- Organizer
  The4th JCA-AACR Special conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club & Resorts(Urayasu)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] The role of nardilysin in intestinal tumorigenesis
- Author(s)
  Hiroshi Seno, Keitaro Kanda, Ei-ichiro Nishi, Tsutomu Chiba
- Organizer
  GI Research Academy 2013
- Place of Presentation
  Hotel Granvia Kyoto(Kyoto)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] The role of Nardilysin in intestinal tumorigenesis.
- Author(s)
  Seno H, Kanda K, Nishi E, Chiba T.
- Organizer
  The 4th symposium on TGF-beta family and cancer.
- Place of Presentation
  茨城県つくば市
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling
- Author(s)
  Chiba T, Kanda K, Seno H, Nishi E
- Organizer
  Singapore Gastric Cancer Consortium, 6th Annual Scientific Meeting
- Place of Presentation
  NUHS Tower Block Auditorium (Singapore)
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] Identification of Dclk1 as aspecific tumor stem cell marker in the intestine　腸腫瘍幹細胞マーカーDclk1の同定
- Author(s)
  中西祐貴、妹尾　浩、上尾太郎、千葉　勉
- Organizer
  第72回日本癌学会学術集会・International Sessions
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 腫瘍肝細胞による腫瘍組織構築機構の検討
- Author(s)
  中西祐貴、妹尾　浩、千葉　勉
- Organizer
  第50回日本臨床分子医学会学術集会・学術奨励賞
- Place of Presentation
  東京国際フォーラム(東京)
- Data Source
  KAKENHI-PROJECT-24659363

1. FUKUDA Akihisa (70644897)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
2. MINAMI Manabu (90511907)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 中西祐貴 (40838679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. CHIBA Tsutomu (30188487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
5. NABESHIMA Motoshige (80314178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYAMOTO Shinichi (90378761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 澤田光孝 (70235472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 児玉裕三 (80378687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 塩川雅広 (50737880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 増田充弘 (60512530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田中求 (00706814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 垣内伸之 (90839721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. NAKATSUJI Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. YASUI Mika

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. FUJIKAWA Risako

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. HIGUCHI Sei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. FUKUMITSU Ryu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IKEDO Taichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAGATA Manabu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HAYASHI Kosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MIYATA Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YANG Tao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KURIYAMA Katsutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. KOBAYASHI Taeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. UEO Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. SHIRAISHI Yuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. KOMEKADO Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. MASUI Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. KIMURA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. NISHI Eiichirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. OSHIMA Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 影山龍一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
33. 横出正之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 米原伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 高石繁生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 鶴山竜昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 高井淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. 恵荘裕嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
39. 丸澤宏之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 山本修司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 昆彩奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 宮野悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 牧島秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 竹内理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 神田啓太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 西英一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
48. 津田喬之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 上本伸二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 稲垣暢也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 大野美紀子

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# of Collaborated Products: 2 results
52. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 森満

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# of Collaborated Products: 1 results
54. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 小杉眞司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 西川義浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 上杉志成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 西川元也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 平岡義範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 長澤丘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seno Hiroshi 妹尾 浩

SENO Hiroshi 妹尾 浩

妹尾 浩 セノオ ヒロシ

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超初期段階から引き返す膵発がん予防戦略の探求Principal Investigator

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分化の揺らぎを克服する新規大腸がん治療戦略の構築Principal Investigator

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Live imaging of human pancreatic cancer stem cell dynamicsPrincipal Investigator

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Therapeutic strategy against gastrointestinal cancer by utilizing cancer hierarchyPrincipal Investigator

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Nrd1 as a novel therapeutic target against colorectal cancerPrincipal Investigator

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Anti-cancer therapies baesd on novel cancer stem cell-specific factorsPrincipal Investigator

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がん微小環境における細胞外シェディングと核内転写の一元的制御Principal Investigator

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Seno Hiroshi 妹尾浩

SENO Hiroshi 妹尾浩

妹尾浩セノオヒロシ