Seno Hiroshi 妹尾浩

… Alternative Names

SENO Hiroshi 妹尾浩

妹尾浩セノオヒロシ

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Researcher Number	90335266
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2015 – 2025: 京都大学, 医学研究科, 教授 2016: 京都大学, 大学院医学研究科, 教授 2015 – 2016: 京都大学, 医学(系)研究科(研究院), 教授 2011 – 2014: 京都大学, 医学(系)研究科(研究院), 講師 2013: 京都大学, 医学研究科, 講師 … More 2013: 京都大学, 大学院医学研究科, 講師 2008 – 2010: Kyoto University, 医学研究科, 講師 2002 – 2004: 京都大学, 医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Biological Sciences / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 50010:Tumor biology-related / Basic Section 54020:Connective tissue disease and allergy-related / General pharmacology / Pathological medical chemistry
Keywords	Principal Investigator 癌 / 大腸 / 炎症 / 大腸癌 / マウス / 大腸がん / Gas6 / IL-6 / 膵臓 / 腫瘍 … More / マクロファージ / 分化 / 膵がん / がん / 難治がん / 内科 / 可塑性 / 膵臓癌 / cytokine / stroma / tumorigenesis / inflammation / β-catenin / colon / COX-2 / Th-1 / 上皮・間質相互作用 / β一カテニン / サイトカイン / 間質 / 発癌 / β-カテニン / 胃 / 消化器 / 幹細胞 / 転写 / シェディング / 自然免疫 / 腸炎 / 腸 / ApcMin / 内視鏡 / M2 / CDX1 / CDX2 / ホメオボックス遺伝子 / 腸上皮化生 / 胃癌 … More Except Principal Investigator 膵癌 / 大腸癌 / 慢性炎症 / 大腸がん / クロマチンリモデリング / マウスモデル / 癌幹細胞 / マクロファージ / がん免疫 / 腫瘍微小環境 / 癌免疫療法 / 応力緩和 / 慢性閉塞性肺疾患 / 浸潤 / 転移 / 自然選択 / 前癌病変 / ゲノム異常 / バイオインフォマティクス / ドライバー遺伝子 / 網羅的ゲノム解析 / クローン進化 / 腫瘍進化 / クローン拡大 / ドライバー変異 / 定量的バイオマーカー / 機械学習 / 数理モデル / オルガノイド / 時空間ダイナミクス / 臨床ヒト試料 / 消化器がん / バイオマーカー / 自己抗体 / 自己抗原 / 自己免疫性膵炎 / IgG4関連疾患 / エピジェネティクス / 治療 / 治療標的 / 膵がん / クロマチンリモデリング因子 / 分子機序 / シグナル情報伝達系 / 翻訳後修飾 / シグナル情報伝達 / EPRAP / 膵臓癌 / IPMN / 膵臓がん / 分子標的治療 / 癌幹細胞治療 / 大腸ポリープ / Dckl1 / Hes1 / 組織幹細胞 / シグナル伝達 / 細胞内シグナル伝達 / 分子病態学 / パネート細胞 / Hes-1 / 小腸幹細胞 / Musashi-1 Less

高悪性度消化器がんの免疫微小環境における「内部と外部」制御因子の解明
- Principal Investigator
  
  中西祐貴
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
ヒト膵癌の転移、進行におけるRECKの機能的役割の解明
- Principal Investigator
  
  福田晃久
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
肺胞上皮のin vitro モデルを用いたCOPD 進行メカニズムの解明
- Principal Investigator
  
  田中求
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyoto University
大腸がん幹細胞の可塑性を制御する時空間的メカニズムの解析Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Strategies to prevent progression from premalignant lesion to cancer in the pancreasPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kyoto University
ハイブリッド療法による大腸がん治療抵抗性メカニズムの克服
- Principal Investigator
  
  中西祐貴
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Physical Biomarkers Based on Dynamics of Cancer Cells and Organoids
- Principal Investigator
  
  Tanaka Motomu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyoto University
Deciphering colorectal carcinogenesis by the genomic analysis of colorectal epithelial cells
- Principal Investigator
  
  Kakiuchi Nobuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
Novel therapeutic strategy against colorectal cancer by intervening fluctuated differentiation statusPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Live imaging of human pancreatic cancer stem cell dynamicsPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kyoto University
The functional role of chromatin regulator in established PDAC
- Principal Investigator
  
  Fukuda Akihisa
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Elucidation of pathophysiology and establishment of new diagnostic system for IgG4-related disease by autoantigen identification
- Principal Investigator
  
  Kodama Yuzo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
Therapeutic strategy against gastrointestinal cancer by utilizing cancer hierarchyPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Nrd1 as a novel therapeutic target against colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Anti-cancer therapies baesd on novel cancer stem cell-specific factorsPrincipal Investigator
- Principal Investigator
  
  Seno Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Role of EPRAP on the pathophysiology of chronic inflammatory diseases
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
がん微小環境における細胞外シェディングと核内転写の一元的制御Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
The functional role of chromatin remodeling regualtor Brg1 in pancreatic cancer
- Principal Investigator
  
  Fukuda Akihisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Identification of specific markers for cancer stem cells and anti-cancer therapy targeting cancer stem cells
- Principal Investigator
  
  CHIBA Tsutomu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Role of EP4 receptor-associated protein in regulating macrophage activation
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Inhibitory role of Gas6-mediated innate immunity in intestinal tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SENO Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Prevention and treatment of colorectal cancer by regulating macrophage activation.Principal Investigator
- Principal Investigator
  
  SENO Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Identification of novel stromal factors that regulate β-catenin localization in colorectal cancer --Prevention of invasion and metastasis in colorectal cancer--Principal Investigator
- Principal Investigator
  
  NABESHIMA Motoshige, 妹尾浩
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KINKI UNIVERSITY
  Kyoto University
小腸幹細胞の同定とその維持・分化に関わるRNA結合蛋白Musashi-1の解析
- Principal Investigator
  
  澤田光孝
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
ホメオボックス遺伝子CDX1,2が胃癌の悪性度に及ぼす影響についての検討Principal Investigator
- Principal Investigator
  
  妹尾浩
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University

[Book] Proton pump inhibitors and gastrointestinal side effects. Proton Pump Inhibitors : A Balanced View. Front Gastrointest Res. Vol.322013
- Author(s)
  Nakamura S, Seno H, Chiba T (Chiba T, Malfertheiner P, Satoh H (eds))
- Publisher
  Basel, Karger
- Data Source
  KAKENHI-PROJECT-23590937
[Book] pylori infection-The route from inflammation to cancer. Sansonetti P, ed, Infection Biology Handbook Series.Bacterial Virulence. Basic principles, models and global approaches.2010
- Author(s)
  Chiba T, Marusawa H, Seno H, Watanabe N.H.
- Publisher
  Willey-Blackwell
- Data Source
  KAKENHI-PROJECT-20599008
[Book] Bacterial Virulence. Basic principles, models and global approaches.2010
- Author(s)
  Chiba T, Seno H, et al.
- Total Pages
  11
- Publisher
  Willey-Blackwell
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Sporadic gastric juvenile polyposis with a novel SMAD4 nonsense mutation in a mosaic pattern.2024
- Author(s)
  Matsuyama S, Fukuda A, Matsumoto A, Eguchi H, Ueo T, Ohana M, Seno H.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 17 Issue: 1 Pages: 23-28
- DOI
  10.1007/s12328-023-01884-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-23K27582
[Journal Article] Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells.2023
- Author(s)
  Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, Kodama Y, Seno H, Nakatsura T, Tamada K, Kaneko S.
- Journal Title
  
  Nat Biomed Eng.
  
  Volume: 7(1) Pages: 24-37
- DOI
  10.1038/s41551-022-00969-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08501, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-22K16301
[Journal Article] Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.2023
- Author(s)
  Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Masui T, Hatano E, Matsuzaki T, Noda M, Seno H.
- Journal Title
  
  J Clin Invest
  
  Volume: 133 Issue: 18
- DOI
  10.1172/jci161847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-22KJ2230, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-23K27582
[Journal Article] On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma2023
- Author(s)
  Ken Kumagai, Takahiro Shimizu, Mitsuhiro Nikaido, Tomonori Hirano, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Sachiko Minamiguchi, Takaki Sakurai, Mari Teramura, Takahiro Utsumi, Yukiko Hiramatsu, Yuki Nakanishi, Atsushi Takai, Shin'ichi Miyamoto, Seishi Ogawa, Hiroshi Seno
- Journal Title
  
  Journal of Pathology
  
  Volume: 259 Issue: 4 Pages: 362-368
- DOI
  10.1002/path.6050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15921, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-21K15972, KAKENHI-PROJECT-23K27582
[Journal Article] Simultaneous activation of Kras?Akt and Notch pathways induces extrahepatic biliary cancer via the <scp>mTORC1</scp> pathway2023
- Author(s)
  Namikawa Mio、Fukuda Akihisa、Omatsu Mayuki、Sono Makoto、Masuda Tomonori、Araki Osamu、Nagao Munemasa、Yoshikawa Takaaki、Ogawa Satoshi、Hiramatsu Yukiko、Muta Yu、Tsuda Motoyuki、Maruno Takahisa、Nakanishi Yuki、Tsuruyama Tatsuaki、Taura Kojiro、Hatano Etsuro、Seno Hiroshi
- Journal Title
  
  The Journal of Pathology
  
  Volume: 260 Issue: 4 Pages: 478-492
- DOI
  10.1002/path.6139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19504, KAKENHI-PROJECT-20K09006, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-22KJ2230, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-23K27582
[Journal Article] Innovative method for the diagnosis of bile duct lesions using a novel tapered-tip sheath system to facilitate biliary biopsies.2023
- Author(s)
  Matsumori T, Uza N, Okada H, Shiokawa M, Maruno T, Kuwada T, Yoshida H, Yasuda M, Yamazaki H, Taura K, Hatano E, Kodama Y, Seno H.
- Journal Title
  
  Gastrointest Endosc
  
  Volume: 98 Issue: 1 Pages: 43-50
- DOI
  10.1016/j.gie.2023.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19480
[Journal Article] Concomitant occurrence of pancreatic cancer during long-term follow-up for serous neoplasms.2023
- Author(s)
  Matsumori T, Uza N, Shiokawa M, Maruno T, Seno H.
- Journal Title
  
  J Med Ultrason
  
  Volume: 50 Issue: 3 Pages: 451-452
- DOI
  10.1007/s10396-023-01327-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19480
[Journal Article] ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.2023
- Author(s)
  Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H.
- Journal Title
  
  J Pathol
  
  Volume: 261 Issue: 1 Pages: 28-42
- DOI
  10.1002/path.6144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-22K15528, KAKENHI-PROJECT-23K27582
[Journal Article] Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway2023
- Author(s)
  Araki Osamu、Tsuda Motoyuki、Omatsu Mayuki、Namikawa Mio、Sono Makoto、Fukunaga Yuichi、Masuda Tomonori、Yoshikawa Takaaki、Nagao Munemasa、Ogawa Satoshi、Masuo Kenji、Goto Norihiro、Muta Yu、Hiramatsu Yukiko、Maruno Takahisa、Nakanishi Yuki、Koyasu Sho、et al.
- Journal Title
  
  Oncogene
  
  Volume: 42 Issue: 26 Pages: 2139-2152
- DOI
  10.1038/s41388-023-02716-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15879, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-22KJ2230, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-23K27582
[Journal Article] Comprehensive analyses of the clinicopathological features and genomic mutations of combined hepatocellular‐cholangiocarcinoma2023
- Author(s)
  Ito Takashi、Ishii Takamichi、Takeda Haruhiko、Sumiyoshi Shinji、Tomofuji Katsuhiro、Wakama Satoshi、Makino Kenta、Horie Hiroshi、Kumagai Ken、Takai Atsushi、Uebayashi Elena Yukie、Ogiso Satoshi、Fukumitsu Ken、Haga Hironori、Seno Hiroshi、Hatano Etsuro
- Journal Title
  
  Hepatology Research
  
  Volume: 54 Issue: 1 Pages: 103-115
- DOI
  10.1111/hepr.13965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08689, KAKENHI-PROJECT-21K19480
[Journal Article] p53 protects against formation of extrahepatic biliary precancerous lesions in the context of oncogenic Kras.2023
- Author(s)
  Munemasa Nagao, Kenta Mizukoshi, Shinnosuke Nakayama, Mio Namikawa, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Akihisa Fukuda*, Hiroshi Seno. *corresponding author
- Journal Title
  
  Oncotarget
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03639
[Journal Article] THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer2023
- Author(s)
  Omatsu Mayuki、Nakanishi Yuki、Kasashima Hiroaki、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 5534-5534
- DOI
  10.1038/s41467-023-41095-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15480, KAKENHI-PROJECT-22K08504, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-22K19458, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-22KJ2230, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-20H05697, KAKENHI-PROJECT-21H04807, KAKENHI-PROJECT-23K27582
[Journal Article] In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy2022
- Author(s)
  Okada H, Takahashi K, Yaku H, Kobiyama K, Iwaisako K, Zhao X, Shiokawa M, Uza N, Kodama Y, Ishii KJ, Seno H.
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 2132-2132
- DOI
  10.1038/s41598-022-05702-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-20K08996, KAKENHI-PROJECT-21K20802, KAKENHI-PROJECT-20K08329
[Journal Article] <scp>JNK</scp> pathway plays a critical role for expansion of human colorectal cancer in the context of <scp>BRG1</scp> suppression2022
- Author(s)
  Yoshikawa Takaaki、Fukuda Akihisa、Omatsu Mayuki、Namikawa Mio、Sono Makoto、Fukunaga Yuichi、Masuda Tomonori、Araki Osamu、Nagao Munemasa、Ogawa Satoshi、Masuo Kenji、Goto Norihiro、Hiramatsu Yukiko、Muta Yu、Tsuda Motoyuki、Maruno Takahisa、Nakanishi Yuki、Kawada Kenji、Takaishi Shigeo、Seno Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 10 Pages: 3417-3427
- DOI
  10.1111/cas.15520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-23K21432
[Journal Article] Multiple pancreatic neuroendocrine tumors in OFCD syndrome caused by somatic BCOR mosaicism2022
- Author(s)
  Yamauchi Y, Kodama Y, Kakiuchi N, Seno H
- Journal Title
  
  Pancreatology.
  
  Volume: 22 Issue: 2 Pages: 335-337
- DOI
  10.1016/j.pan.2021.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19480
[Journal Article] Concurrent activation of Kras and canonical Wnt signaling induces premalignant lesions that progress to extrahepatic biliary cancer in mice2022
- Author(s)
  Nagao M, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Taketo MM, Ferrer J, Tsuruyama T, Nakanuma Y, Taura K, Uemoto S, Seno H.
- Journal Title
  
  Cancer Res.
  
  Volume: - Issue: 9 Pages: 1803-1817
- DOI
  10.1158/0008-5472.can-21-2176
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22841, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-21K20801, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-23K21432
[Journal Article] Inhibition of dopamine receptor <scp>D1</scp> signaling promotes human bile duct cancer progression via <scp>WNT</scp> signaling2022
- Author(s)
  Yogo Akitada、Masui Toshihiko、Takaishi Shigeo、Masuo Kenji、Chen Ru、Kasai Yosuke、Nagai Kazuyuki、Anazawa Takayuki、Watanabe Sadanori、Sakamoto Satoko、Watanabe Akira、Inagaki Ryosaku、Nakagawa Masahiro M.、Ogawa Seishi、Seno Hiroshi、Uemoto Shinji、Hatano Etsuro
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 4 Pages: 1324-1336
- DOI
  10.1111/cas.15676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08732, KAKENHI-PROJECT-22K08798, KAKENHI-PROJECT-23K27582
[Journal Article] Tuft cell-like carcinomas: novel cancer subsets present in multiple organs sharing a unique gene expression signature2022
- Author(s)
  Yamada Yosuke、Bohnenberger Hanibal、Kriegsmann Mark、Kriegsmann Katharina、Sinn Peter、Goto Norihiro、Nakanishi Yuki、Seno Hiroshi、Chigusa Yoshitsugu、Fujimoto Masakazu、Minamiguchi Sachiko、Haga Hironori、Simon Ronald、Sauter Guido、Str?bel Philipp、Marx Alexander
- Journal Title
  
  British Journal of Cancer
  
  Volume: 127 Issue: 10 Pages: 1876-1885
- DOI
  10.1038/s41416-022-01957-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06902, KAKENHI-PROJECT-23K21432
[Journal Article] Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization2022
- Author(s)
  Kumagai Ken、Shimizu Takahiro、Takai Atsushi、Kakiuchi Nobuyuki、Takeuchi Yasuhide、Hirano Tomonori、Takeda Haruhiko、Mizuguchi Aya、Teramura Mari、Ito Takahiko、Iguchi Eriko、Nikaido Mitsuhiro、Eso Yuji、Takahashi Ken、Ueda Yoshihide、Miyamoto Shin-ichi、Obama Kazutaka、Ogawa Seishi、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Cancer Research
  
  Volume: - Issue: 9 Pages: 1712-1723
- DOI
  10.1158/0008-5472.can-21-1523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15781, KAKENHI-PROJECT-20H03513, KAKENHI-PROJECT-21K15972, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-21K20836
[Journal Article] Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation.2022
- Author(s)
  Marui S, Nishikawa Y, Shiokawa M, Yokode M, Matsumoto S, Muramoto Y, Ota S, Nakamura T, Yoshida H, Okada H, Kuwada T, Matsumori T, Kuriyama K, Fukuda A, Saur D, Aoi T, Uza N, Kodama Y, Chiba T, Seno H.
- Journal Title
  
  Gastroenterology.
  
  Volume: 163 Issue: 6 Pages: 1613-1629
- DOI
  10.1053/j.gastro.2022.08.048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-20J01362
[Journal Article] Genetic Landscape of Multistep Hepatocarcinogenesis2022
- Author(s)
  Takeda Haruhiko、Takai Atsushi、Eso Yuji、Takahashi Ken、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 3 Pages: 568-568
- DOI
  10.3390/cancers14030568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08443, KAKENHI-PROJECT-20H03659
[Journal Article] Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway.2022
- Author(s)
  Fukunaga Y, Fukuda A, Omatsu M, Namikawa M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Ferrer J, Tsuruyama T, Masui T, Hatano E, Seno H.
- Journal Title
  
  Gastroenterology.
  
  Volume: 163 Issue: 2 Pages: 466-480
- DOI
  10.1053/j.gastro.2022.04.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-23K21432
[Journal Article] Gastric Hyperplastic Polyps Can Shrink After Discontinuation of Proton Pump Inhibitors: A Case Series Compared With Continuation of Proton Pump Inhibitors2022
- Author(s)
  Nikaido M, Miyamoto S, Utsumi T, Shimizu T, Nakanishi Y, Kumagai K, Teramura M, Setoyama T, Seno H.
- Journal Title
  
  J Clin Gastroenterol.
  
  Volume: 56 Issue: 3 Pages: e216-e221
- DOI
  10.1097/mcg.0000000000001577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03659
[Journal Article] Identification of an Anti?Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis2021
- Author(s)
  Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, Yamazaki H, Yoshida H, Nakamura T, Matsumoto S, Muramoto Y, Yamamoto S, Honzawa Y, Kuriyama K, Okamoto K, Hirano T, Okada H, Marui S, Sogabe Y, Morita T, Matsumori T, Mima A, Nishikawa Y, Ueda T, Matsumura K, Uza N, Chiba T, Seno H
- Journal Title
  
  Gastroenterology
  
  Volume: - Issue: 7 Pages: 2383-2394
- DOI
  10.1053/j.gastro.2021.02.019
- NAID
  120006976020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17398, KAKENHI-PROJECT-19K17487, KAKENHI-PROJECT-20K22937, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-21K19480
[Journal Article] The clinical efficacy of azathioprine as maintenance treatment for autoimmune pancreatitis: a systematic review and meta-analysis.2021
- Author(s)
  Masaki Y, Nakase H, Tsuji Y, Nojima M, Shimizu K, Mizuno N, Ikeura T, Uchida K, Ido A, Kodama Y, Seno H, Okazaki K, Nakamura S, Masamune A.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 56 Issue: 10 Pages: 869-880
- DOI
  10.1007/s00535-021-01817-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03698, KAKENHI-PROJECT-21K07943
[Journal Article] Factors associated with inaccurate size estimation of colorectal polyps: A multicenter cross-sectional study2021
- Author(s)
  Utsumi T, Horimatsu T, Nishikawa Y, Teramoto A, Hirata D, Iwatate M, Tanaka S, Ikezawa N, Esaki M, Osera S, Ebisutani C, Agatsuma N, Saito H, Sano Y, Seno H.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 36 Issue: 8 Pages: 2224-2229
- DOI
  10.1111/jgh.15464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03659
[Journal Article] Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development2021
- Author(s)
  Kuriyama K, Kodama Y, Shiokawa M, Nishikawa Y, Marui S, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Matsumori T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Kageyama R, Chiba T, Seno H.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 56(7) Issue: 7 Pages: 673-687
- DOI
  10.1007/s00535-021-01779-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-21K19480
[Journal Article] Brg1 is required to maintain colorectal cancer stem cells2021
- Author(s)
  Yoshikawa Takaaki、Fukuda Akihisa、Omatsu Mayuki、Namikawa Mio、Sono Makoto、Fukunaga Yuichi、Masuda Tomonori、Araki Osamu、Nagao Munemasa、Ogawa Satoshi、Masuo Kenji、Goto Norihiro、Hiramatsu Yukiko、Muta Yu、Tsuda Motoyuki、Maruno Takahisa、Nakanishi Yuki、Kawada Kenji、Takaishi Shigeo、Seno Hiroshi
- Journal Title
  
  The Journal of Pathology
  
  Volume: 255 Issue: 3 Pages: 257-269
- DOI
  10.1002/path.5759
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22841, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-23K21432
[Journal Article] Brg1 is required to maintain colorectal cancer stem cells.2021
- Author(s)
  Yoshikawa T, Fukuda A*, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Kawada K, Takaishi S, Seno H.
- Journal Title
  
  J Pathology
  
  Volume: 255 Pages: 257-269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03639
[Journal Article] Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development2021
- Author(s)
  Kuriyama K, Kodama Y, Shiokawa M, Nishikawa Y, Marui S, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Matsumori T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Kageyama R, Chiba T, Seno H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 56 Pages: 673-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03659
[Journal Article] Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging2021
- Author(s)
  Maruno Takahisa、Fukuda Akihisa、Goto Norihiro、Tsuda Motoyuki、Ikuta Kozo、Hiramatsu Yukiko、Ogawa Satoshi、Nakanishi Yuki、Yamaga Yuichi、Yoshioka Takuto、Takaori Kyoichi、Uemoto Shinji、Saur Dieter、Chiba Tsutomu、Seno Hiroshi
- Journal Title
  
  eLife
  
  Volume: 10 Pages: 1-24
- DOI
  10.7554/elife.55117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22841, KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-18J01600, KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-19K16712
[Journal Article] Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40-69-years subjects2021
- Author(s)
  Shinya Ohashi, Takahisa Maruno, Keita Fukuyama, Osamu Kikuchi, Tomohiko Sunami, Ｙuki Ｋondo, Ｓeiichiro Ｉmai, Ｍatsushima Ａki, Ｋimiyo Ｓuzuki, Ｆumika Ｕsui, Ｍasahiro Ｙakami, Ａtsushi Yamada, Hiroyoshi Isoda, Shigemi Matsumoto, Hiroshi Seno, Manabu Muto, Mayumi Inoue
- Journal Title
  
  Esophagus
  
  Volume: 18 Issue: 4 Pages: 889-899
- DOI
  10.1007/s10388-021-00859-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-20H03659
[Journal Article] Interinstitutional differences in diagnosis of the morphology of colorectal polyps in Japan: a nationwide database analysis2021
- Author(s)
  Utsumi T, Horimatsu T, Nishikawa Y, Seno H.
- Journal Title
  
  Eur J Gastroenterol Hepatol.
  
  Volume: 33 Issue: 1S Pages: e1072-e1073
- DOI
  10.1097/meg.0000000000002022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03659
[Journal Article] Medical costs according to the stages of colorectal cancer: an analysis of health insurance claims in Hachioji, Japan2021
- Author(s)
  Utsumi T, Horimatsu T, Nishikawa Y, Hoshino N, Takahashi Y, Goto R, Kashihara S, Fukuyoshi J, Nakayama T, Seno H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 56 Issue: 10 Pages: 903-913
- DOI
  10.1007/s00535-021-01798-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-20K20279, KAKENHI-PROJECT-23K20622
[Journal Article] The role of SWI/SNF chromatin remodeling complex in pancreatic cancer. *corresponding author2021
- Author(s)
  2.Motoyuki Tsuda, Akihisa Fukuda, Munenori Kawai, Osamu Araki, Hiroshi Seno.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 2 Pages: 490-497
- DOI
  10.1111/cas.14768
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-19K22619
[Journal Article] Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations2021
- Author(s)
  Nikaido Mitsuhiro、Ogawa Seishi, et al.
- Journal Title
  
  Gastric Cancer
  
  Volume: 24 Issue: 5 Pages: 1102-1114
- DOI
  10.1007/s10120-021-01191-8
- NAID
  40022653243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-21K15972
[Journal Article] SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP22021
- Author(s)
  Masuo K, Chen R, Yogo A, Sugiyama A, Fukuda A, Masui T, Uemoto S, Seno H, Takaishi S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 12 Pages: 4987-4999
- DOI
  10.1111/cas.15162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-19H03639
[Journal Article] A novel technique for mapping biopsy of bile duct cancer.2021
- Author(s)
  Okada H, Uza N, Matsumori T, Matsumoto S, Muramoto Y, Ota S, Nakamura T, Yoshida H, Hirano T, Kuwada T, Marui S, Sogabe Y, Morita T, Kakiuchi N, Mima A, Ueda T, Nishikawa Y, Tsuda M, Maruno T, Shiokawa M, Takahashi K, Taura K, Minamiguchi S, Kodama Y, Seno H.
- Journal Title
  
  Endoscopy.
  
  Volume: 53 Issue: 06 Pages: 647-651
- DOI
  10.1055/a-1248-2138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19480
[Journal Article] Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma2020
- Author(s)
  Matsumori T, Kodama Y, Takai A, Shiokawa M, Nishikawa Y, Matsumoto T, Takeda H, Marui S, Okada H, Hirano T, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Marusawa H, Kageyama R, Chiba T, Seno H.
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 23 Pages: 5305-5316
- DOI
  10.1158/0008-5472.can-20-1161
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Short educational video to improve the accuracy of colorectal polyp size estimation: Multicenter prospective study.2020
- Author(s)
  Utsumi T, Horimatsu T, Nishikawa Y, Teramoto A, Hirata D, Iwatate M, Sano Y, Seno H.
- Journal Title
  
  Dig Endosc
  
  Volume: 32 Issue: 7 Pages: 1074-1081
- DOI
  10.1111/den.13638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis.2020
- Author(s)
  Niwamoto T, Handa T, Matsui S, Yamamoto H, Yoshifuji H, Abe H, MatsumotoH, Kodama Y, Chiba T, Seno H, Mimori T, Hirai T.
- Journal Title
  
  Modern Rheumatology
  
  Volume: in press Issue: 1 Pages: 235-240
- DOI
  10.1080/14397595.2019.1703522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08649, KAKENHI-PROJECT-19K08645, KAKENHI-PROJECT-18K07958, KAKENHI-PROJECT-19H03698
[Journal Article] Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors2020
- Author(s)
  Yamauchi Yuki、Kodama Yuzo、Uza Norimitsu、Masuda Atsuhiro、Tatsuoka Hisato、Masui Toshihiko、Inagaki Nobuya、Uemoto Shinji、Chiba Tsutomu、Seno Hiroshi
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 17 Pages: 3620-3630
- DOI
  10.1158/0008-5472.can-19-2232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08677, KAKENHI-PROJECT-20K21616, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Setdb1 inhibits p53-mediated apoptosis and is required for formation of pancreatic ductal adenocarcinomas in mice.2020
- Author(s)
  6.Ogawa S, Fukuda A, Matsumoto Y, Hanyu Yu, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T, Goto N, Hiramatsu Y, Tsuda M, Maruno T, Nakanishii Y, Hussein S.M, Tsuruyama T, Takaori K, Uemotoio　S, Seno H.
- Journal Title
  
  Gastroenterology
  
  Volume: 159 Issue: 2 Pages: 682-696
- DOI
  10.1053/j.gastro.2020.04.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03639, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-18J01600, KAKENHI-PROJECT-19K22619
[Journal Article] CXCR4 in tumor epithelial cells mediates desmoplastic reaction in pancreatic ductal adenocarcinoma.2020
- Author(s)
  Morita, T., Kodama, Y., Shiokawa, M., Kuriyama, K., Marui, S., Kuwada, T., Sogabe, Y., Matsumori, T., Kakiuchi, N., Tomono, T., Mima, A., Ueda, T., Tsuda, M., Yamauchi, Y., Nishikawa, Y., Sakuma, Y., Ota, Y., Maruno, T., Uza, N., Nagasawa, T., Chiba, T., and Seno, H.
- Journal Title
  
  Cancer Res.
  
  Volume: 80 Issue: 19 Pages: 4058-4070
- DOI
  10.1158/0008-5472.can-19-2745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03998, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-19K22619
[Journal Article] Epithelial EP4 plays an essential role in maintaining homeostasis in colon.2019
- Author(s)
  Matsumoto Y, Nakanishi Y, Yoshioka T, Yamaga Y, Masuda T, Fukunaga Y, Sono M, Yoshikawa T, Nagao M, Araki O, Ogawa S, Goto N, Hiramatsu Y, Breyer RM, Fukuda A, Seno H.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 15244-15244
- DOI
  10.1038/s41598-019-51639-2
- NAID
  120006956728
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-17H04157
[Journal Article] Bmi1 marks gastric stem cells located in the isthmus in mice.2019
- Author(s)
  Yoshioka T, Fukuda A, Araki O, Ogawa S, Hanyu Y, Matsumoto Y, Yamaga Y, Nakanishi Y, Kawada K, Sakai Y, Chiba T, Seno H.
- Journal Title
  
  J Pathol.
  
  Volume: 248 Issue: 2 Pages: 179-190
- DOI
  10.1002/path.5244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-17H04157
[Journal Article] Arid1a is essential for intestinal stem cells through Sox9 regulation.2019
- Author(s)
  Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 116 (5) Issue: 5 Pages: 1704-1713
- DOI
  10.1073/pnas.1804858116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-17H04059, KAKENHI-PROJECT-17H04157
[Journal Article] Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis2019
- Author(s)
  Kakiuchi Nobuyuki et al.
- Journal Title
  
  Nature
  
  Volume: 577 Issue: 7789 Pages: 260-265
- DOI
  10.1038/s41586-019-1856-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K15747, KAKENHI-PROJECT-18K16084, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-19H04806, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-19H03560, KAKENHI-PROJECT-17J05245, KAKENHI-PROJECT-15H05707, KAKENHI-PROJECT-18H05278
[Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis2019
- Author(s)
  Nishikawa Y、Kodama Y、Shiokawa M、Matsumori T、Marui S、Kuriyama K、Kuwada T、Sogabe Y、Kakiuchi N、Tomono T、Mima A、Morita T、Ueda T、Tsuda M、Yamauchi Y、Sakuma Y、Ota Y、Maruno T、Uza N、Uesugi M、Kageyama R、Chiba T、Seno H
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 22 Pages: 4283-4296
- DOI
  10.1038/s41388-019-0718-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-17H06803, KAKENHI-PROJECT-16K09395, KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-19J01318, KAKENHI-PROJECT-18K16149, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-26220206
[Journal Article] Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells.2019
- Author(s)
  Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 116 Issue: 26 Pages: 12996-13005
- DOI
  10.1073/pnas.1900251116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22619, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-18J01600
[Journal Article] ARID1A Maintains Differentiation of Pancreatic Ductal Cells and inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice2018
- Author(s)
  Yoshito Kimura, Akihisa Fukuda, Satoshi Ogawa, Takahisa Maruno, Yutaka Takada, Motoyuki Tsuda, Yukiko Hiramatsu, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Kozo Ikuta, Takuto Yoshioka, Zong Wang, Haruhiko Akiyama, Christopher V. Wright, Kyoichi Takaori, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno
- Journal Title
  
  Gastroenterology
  
  Volume: 3 Issue: 1 Pages: 30346-9
- DOI
  10.1053/j.gastro.2018.03.039
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09394, KAKENHI-PROJECT-17J05511, KAKENHI-PROJECT-17H04157
[Journal Article] Gene expression profile of Dclk1+ cells in intestinal tumors.2018
- Author(s)
  Yamaga Y, Fukuda A, Nakanishi Y, Goto N, Matsumoto Y, Yoshioka T, Maruno T, Chiba T, Seno H.
- Journal Title
  
  Dig Liver Dis.
  
  Volume: 50 Issue: 12 Pages: 1353-1361
- DOI
  10.1016/j.dld.2018.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04157
[Journal Article] Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.2018
- Author(s)
  Sakuma Y, Kodama Y, Eguchi T, Uza N, Tsuji Y, Shiokawa M, Maruno T, Kuriyama K, Nishikawa Y, Yamauchi Y, Tsuda M, Ueda T, Matsumori T, Morita T, Tomono T, Kakiuchi N, Mima A, Sogabe Y, Marui S, Kuwada T, Okada A, Watanabe T, Nakase H, Chiba T, Seno H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 8829-8829
- DOI
  10.1038/s41598-018-27200-y
- NAID
  120006532078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04157
[Journal Article] Updated Trends in Gallbladder and Other Biliary Tract Cancers Worldwide2018
- Author(s)
  Matsumoto Tomonori、Seno Hiroshi
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: 16 Issue: 3 Pages: 339-340
- DOI
  10.1016/j.cgh.2017.11.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15427
[Journal Article] The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.2018
- Author(s)
  Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H.
- Journal Title
  
  J Clin Invest.
  
  Volume: 128 Issue: 8 Pages: 3475-3489
- DOI
  10.1172/jci94287
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-17H06805, KAKENHI-PROJECT-16K09394, KAKENHI-PROJECT-16K15613
[Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53?dependent transcriptional regulation2018
- Author(s)
  Kanda Keitaro、Sakamoto Jiro、Matsumoto Yoshihide、Ikuta Kozo、Goto Norihiro、Morita Yusuke、Ohno Mikiko、Nishi Kiyoto、Chiba Tsutomu、Nishi Eiichiro、Seno Hiroshi
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 8 Pages: 1-15
- DOI
  10.1172/jci.insight.91316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09575, KAKENHI-PROJECT-16H05297, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-15J03212, KAKENHI-PROJECT-16K15216, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-18H04164
[Journal Article] Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease2018
- Author(s)
  Eso Yuji、Takai Atsushi、Taura Kojiro、Takahashi Ken、Ueda Yoshihide、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 印刷中 Issue: 9 Pages: 1649-1658
- DOI
  10.1111/jgh.14130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-16K09357
[Journal Article] Tumor invasion to the arteries feeding the gallbladder as a novel risk factor for cholecystitis after metallic stent placement in distal malignant biliary obstruction2017
- Author(s)
  Sogabe Yuko、Kodama Yuzo、Honjo Hajime、Aoyama Ikuo、Kawanami Chiharu, Seno Hiroshi, et al.
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 印刷中 Issue: 3 Pages: 380-387
- DOI
  10.1111/den.12991
- NAID
  130007569115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04157
[Journal Article] Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma2017
- Author(s)
  Matsumoto Tomonori、Takai Atsushi、Eso Yuji、Kinoshita Kazuo、Manabe Toshiaki、Seno Hiroshi、Chiba Tsutomu、Marusawa Hiroyuki
- Journal Title
  
  Cancer Research
  
  Volume: 77 Issue: 22 Pages: 6131-6143
- DOI
  10.1158/0008-5472.can-17-1800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09357, KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-17H04158, KAKENHI-PROJECT-16K15427
[Journal Article] Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors2017
- Author(s)
  Kou Tadayuki、Kanai Masashi、Yamamoto Yoshihiro、Kamada Mayumi、Nakatsui Masahiko、Sakuma Tomohiro、Mochizuki Hiroaki、Hiroshima Akinori、Sugiyama Aiko、Nakamura Eijiro、Miyake Hidehiko、Minamiguchi Sachiko、Takaori Kyoichi、Matsumoto Shigemi、Haga Hironori、Seno Hiroshi、Kosugi Shinji、Okuno Yasushi、Muto Manabu
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 7 Pages: 1440-1446
- DOI
  10.1111/cas.13265
- NAID
  120006333897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08646, KAKENHI-PROJECT-16K15427
[Journal Article] Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.2017
- Author(s)
  Basak O, Beumer J, Wiebrands K, Seno H, van Oudenaarden A, Clevers H.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 20 Issue: 2 Pages: 177-190
- DOI
  10.1016/j.stem.2016.11.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma2017
- Author(s)
  Eso Yuji、Uza Norimitsu、Yamagishi Hiroko、Imada Kazuaki、Kimura Yuto、Masui Toshihiko、Kodama Yuzo、Seno Hiroshi
- Journal Title
  
  Medicine
  
  Volume: 96 Issue: 50 Pages: e9217-e9217
- DOI
  10.1097/md.0000000000009217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15938, KAKENHI-PROJECT-17H04157
[Journal Article] Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine2017
- Author(s)
  Goto Norihiro、Ueo Taro、Fukuda Akihisa、Kawada Kenji、Sakai Yoshiharu、Miyoshi Hiroyuki、Taketo Makoto Mark、Chiba Tsutomu、Seno Hiroshi
- Journal Title
  
  Cancer Research
  
  Volume: 77 Issue: 13 Pages: 3442-3454
- DOI
  10.1158/0008-5472.can-16-3192
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157, KAKENHI-PROJECT-15J03212, KAKENHI-PROJECT-16K15427
[Journal Article] Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach2017
- Author(s)
  Kimura Y, Ikuta K, Kimura T, Chiba T, Oshima H, Oshima M, *Nishi E, *Seno H
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 43052-43052
- DOI
  10.1038/srep43052
- NAID
  120006355734
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293068, KAKENHI-PROJECT-26293173, KAKENHI-PROJECT-16K07111, KAKENHI-PROJECT-16K15216, KAKENHI-PROJECT-16K15427
[Journal Article] Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B.2017
- Author(s)
  Matsumoto T, Takahashi K, Inuzuka T, Kim SK, Kurosaki T, Kawakami S, Chiba T, Seno H, Marusawa H.
- Journal Title
  
  Antiviral Research
  
  Volume: 139 Pages: 138-145
- DOI
  10.1016/j.antiviral.2017.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11897, KAKENHI-PROJECT-14J02212, KAKENHI-PROJECT-26293173
[Journal Article] Diagnostic performance of a new “endoscopic scraper” for malignant biliary strictures: A multicenter prospective study.2017
- Author(s)
  Sakuma Y, Kodama Y, Sogabe Y, Nakai Y, Yamashita Y, Mikami S, Kajimura K, Ikeda K, Tamaki H, Iwamoto S, Matsuda F, Fujita K, Uza N, Kawamura T, Uemoto S, Seno H, Chiba T, Yazumi S; Kyoto Pancreatobiliary Study Group.
- Journal Title
  
  Gastrointest Endosc
  
  Volume: 85 Issue: 2 Pages: 371-379
- DOI
  10.1016/j.gie.2016.07.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.2016
- Author(s)
  Takada Y, Fukuda A, Chiba T, Seno H.
- Journal Title
  
  Development
  
  Volume: 143 Pages: 3532-3539
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Pathogenicity of Immunoglobulin G in Patients with IgG4-related Disease.2016
- Author(s)
  Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
- Journal Title
  
  Gut
  
  Volume: 未定 Issue: 8 Pages: 3292-3301
- DOI
  10.1136/gutjnl-2015-310336
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15290, KAKENHI-PROJECT-26893123, KAKENHI-PROJECT-25461022, KAKENHI-PROJECT-26293173, KAKENHI-PROJECT-16K15427, KAKENHI-PROJECT-16K19339
[Journal Article] Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.2016
- Author(s)
  Takada Y, Fukuda A, Chiba T, Seno H.
- Journal Title
  
  Development
  
  Volume: 143 Pages: 3532-3539
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15427
[Journal Article] Endoscopic intraluminal cutting technique for indwelling devices using a lithotripter handle and guidewire.2015
- Author(s)
  Muta Y, Nishikawa Y, Watanabe K, Kawano K, Seno H, Chiba T, Yazumi S.
- Journal Title
  
  Endoscopy
  
  Volume: 47 Issue: S 01 Pages: E251-E252
- DOI
  10.1055/s-0034-1391836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] EP4 receptor–associated protein in macrophages ameliorates colitis and colitis-associated tumorigenesis.2015
- Author(s)
  Nakatsuji, M., M. Minami*, H. Seno*, M. Yasui, H. Komekado, S. Higuchi, R. Fujikawa, Y. Nakanishi, A. Fukuda, K. Kawada, Y. Sakai, T. Kita, P. Libby, H. Ikeuchi, M. Yokode, and T. Chiba
- Journal Title
  
  PLoS Genet
  
  Volume: 11 Issue: 10 Pages: e1005542-e1005542
- DOI
  10.1371/journal.pgen.1005542
- NAID
  120005947032
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-26293173
[Journal Article] Images of the Month: A polypoid lesion in the portal vein.2015
- Author(s)
  Hiramatsu Y, Ida H, Seno H.
- Journal Title
  
  Am J Gastroenterol.
  
  Volume: 110 Issue: 6 Pages: 798-798
- DOI
  10.1038/ajg.2014.397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Breast cancer metastasis to the esophagus diagnosed using endoscopic ultrasound-guided fine-needle aspiration.2015
- Author(s)
  Matsumoto Y, Matsukawa H, Seno H, Ono S.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 30 Issue: 2 Pages: 233-233
- DOI
  10.1111/jgh.12819
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112707, KAKENHI-PROJECT-26293173
[Journal Article] 細胞系譜解析による大腸腫瘍幹細胞特異的な因子の同定2015
- Author(s)
  妹尾浩、山賀雄一、中西祐貴、千葉勉
- Journal Title
  
  日本臨床
  
  Volume: 73 Pages: 850-854
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Deletion of nardilysin prevents the development of steatohepatitis and liver fibrosis.2014
- Author(s)
  Ishizu-Higashi S, Seno H, Nishi E, Matsumoto Y, Ikuta K, Tsuda M, Kimura Y, Takada Y, Kimura Y, Nakanishi Y, Kanda K, Komekado H, Chiba T.
- Journal Title
  
  Plos One
  
  Volume: 9 Issue: 5 Pages: e98017-e98017
- DOI
  10.1371/journal.pone.0098017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590914, KAKENHI-PROJECT-24659363, KAKENHI-PUBLICLY-25112707, KAKENHI-PUBLICLY-25130706, KAKENHI-PROJECT-25860533, KAKENHI-PUBLICLY-26116715, KAKENHI-PROJECT-26293068, KAKENHI-PROJECT-26293173, KAKENHI-PROJECT-26670139
[Journal Article] A case of acute necrotizing esophagitis.2014
- Author(s)
  Kimura Y, Seno H, Yamashita Y.
- Journal Title
  
  Gastrointest Endosc.
  
  Volume: 80 Issue: 3 Pages: 525-526
- DOI
  10.1016/j.gie.2014.03.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Esophageal ulcer due to lymphoma.2014
- Author(s)
  Ikuta K, Umeda M, Seno H.
- Journal Title
  
  Intern Med.
  
  Volume: 53 Pages: 2649-2650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293173
[Journal Article] Molecular changes leading to gastric cancer: a suggestion from rare-type gastric tumors with GNAS mutations.2014
- Author(s)
  Ikuta K, Seno H, Chiba T.
- Journal Title
  
  Gastroenterology
  
  Volume: 146 Issue: 5 Pages: 1417-1418
- DOI
  10.1053/j.gastro.2014.03.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112707, KAKENHI-PUBLICLY-25130706, KAKENHI-PROJECT-26293173
[Journal Article] Dclk1 distinguishes between tumor and normal stem cells in the intestine.2013
- Author(s)
  Yuki Nakanishi, et. al.
- Journal Title
  
  Nature Genetics
  
  Volume: 45 Issue: 1 Pages: 98-103
- DOI
  10.1038/ng.2481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-13J02261, KAKENHI-PROJECT-22370052, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-24590914, KAKENHI-PROJECT-24590916, KAKENHI-PROJECT-24657132, KAKENHI-PROJECT-24659363, KAKENHI-PUBLICLY-25130706
[Journal Article] Inhibitory Role of Gas6 in Intestinal Tumorigenesis.2013
- Author(s)
  Yuki Nakanishi, et. al.
- Journal Title
  
  Carcinogenesis
  
  Volume: (印刷中) Issue: 7 Pages: 1567-1574
- DOI
  10.1093/carcin/bgt069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-24659363, KAKENHI-PUBLICLY-25112707, KAKENHI-PUBLICLY-25130706
[Journal Article] The role of Hes genes in intestinaldevelopment, homeostasis and tumorformation2012
- Author(s)
  Ueo T, Imayoshi T, Kobayashi T, OhtsukaT, Seno H, Nakae H, Chiba T, Kageyama R
- Journal Title
  
  Development
  
  Volume: 139 Issue: 6 Pages: 1071-1082
- DOI
  10.1242/dev.069070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-21240028, KAKENHI-PROJECT-22687017, KAKENHI-PROJECT-22790642, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-24590916, KAKENHI-PROJECT-24659363
[Journal Article] Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-a2012
- Author(s)
  Kanda K, Komekado H, Kawada M, et al
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: (印刷中) Issue: 5 Pages: 396-411
- DOI
  10.1002/emmm.201200216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J40033, KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-22790641, KAKENHI-PUBLICLY-23122510, KAKENHI-PROJECT-23300117, KAKENHI-PROJECT-23590937, KAKENHI-PROJECT-23659154, KAKENHI-PROJECT-23659755, KAKENHI-PROJECT-24590914, KAKENHI-PROJECT-24659363, KAKENHI-PROJECT-24700366, KAKENHI-PUBLICLY-23117519, KAKENHI-PUBLICLY-24113713
[Journal Article] COX-2 inhibition alters the phenotype of tumor associated macrophages from M2 to M1 in ApcMin/+ mouse polyps2011
- Author(s)
  Nakanishi Y, Seno H, Kawada M, et al
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(9) Issue: 9 Pages: 1333-1339
- DOI
  10.1093/carcin/bgr128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J40033, KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-22790642, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937
[Journal Article] Indigenous Clostridium Species regulate systemic immune responses by induction of colonic regulatory T cells.2011
- Author(s)
  Chiba T, Seno H.
- Journal Title
  
  Gastroenterology
  
  Volume: 141 Issue: 3 Pages: 1114-1116
- DOI
  10.1053/j.gastro.2011.07.013
- Data Source
  KAKENHI-PROJECT-23590937
[Journal Article] COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps.2011
- Author(s)
  Nakanishi, Y., M. Nakatsuji, H. Seno, S. Ishizu, R. Akitake-Kawano, K. Kanda, T. Ueo, H. Komekado, M. Kawada, M. Minami, T. Chiba.
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Pages: 1333-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Multiple sexually transmitted infections.2010
- Author(s)
  Nakanishi Y, Seno H, et al.
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 25 Pages: 843-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Metastatic gastrointestinal stromal cell tumor mimicking gastrointestinal polyposis.2010
- Author(s)
  Nakanishi Y, Kanda K, Akitake R, Seno H, Chiba T, Ono K, Kayahara T, Yamashita Y.
- Journal Title
  
  Endoscopy. 42 Suppl 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] 胃ではLgr5陽性細胞が自己再生をにない、さらにこの細胞からin vitroで胃腺窩を長期間構築できた2010
- Author(s)
  上尾太郎、妹尾浩、千葉勉
- Journal Title
  
  分子消化器病 7
  
  Pages: 185-187
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Multiple sexually transmitted infections.2010
- Author(s)
  Nakanishi Y, Seno H, Chiba T, Yamashita Y.
- Journal Title
  
  J Gastoroenterol Hepatol. 25(4)
  
  Pages: 843-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] ポリポーシス症候群の遺伝子異常はどこまで解明されたか2009
- Author(s)
  妹尾浩, ほか
- Journal Title
  
  分子消化器病 6
  
  Pages: 56-61
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Perivascular epithelioid cell tumor (PEComa) of the liver diagnosed by contrast-enhanced ultrasonography.2009
- Author(s)
  Akitake R, Kimura H, Sekoguchi S, Nakamura H, Seno H, Chiba T, Fujimoto S.
- Journal Title
  
  Intern Med. 48(24)
  
  Pages: 2083-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] ポリポーシス症候群の遺伝子異常はどこまで解明されたか2009
- Author(s)
  妹尾浩、中西祐貴、秋武玲子、千葉勉
- Journal Title
  
  分子消化器病 6
  
  Pages: 262-267
- Data Source
  KAKENHI-PROJECT-20599008
[Journal Article] Hypoxia induced by intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1 dependent pathway.2006
- Author(s)
  Uenoyama Y, Seno H, Chiba T, et al.
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006
- Author(s)
  Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara T, Chiba T
- Journal Title
  
  Cancer Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006
- Author(s)
  Kawada M, Seno H, Chiba T, et al.
- Journal Title
  
  Cancer Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Hypoxia induced by intestinal epithelial, cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1 dependent pathway.2006
- Author(s)
  Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 activation is involved in nuclear accumulation of b-cateninin colorectal cancer.2006
- Author(s)
  Kawada M, Seno H, Chiba T, et al.
- Journal Title
  
  Cancer Res (in press)
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Hypoxia induced by intestinal epithelial cells is associated with cyclooxynenase-2 expression in stromal cells through AP-1 dependent pathway.2006
- Author(s)
  Uenoyama Y, Seno H, Chiba T, et al.
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.2005
- Author(s)
  Suzuki K, Fukui H, Kayahara T, Sawada M, Seno H, Hiai H, Kageyama R, Okano H, Chiba T
- Journal Title
  
  Biochem Biophys Res Commun. 328
  
  Pages: 348-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.2005
- Author(s)
  Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, Seno H, Takasawa S, Okamoto H, Fujimori T, Chiba T
- Journal Title
  
  Gastroenterology 128
  
  Pages: 642-653
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] Possible role of REG I{alpha} protein in ulcerative colitis and colitic cancer.2005
- Author(s)
  Sekikawa A, Fukui H, Fujii S, Nanakin A, Kanda N, Uenoyama Y, Sawabu T, Hisatsune H, Kusaka T, Ueno S, Nakase H, Seno H, Fujimori T, Chiba T
- Journal Title
  
  Gut 54
  
  Pages: 1437-1444
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004
- Author(s)
  Kanda N, Seno H, Konda Y, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, Sekikawa A, Kawada M, Suzuki K, Kayahara T, Fukui H, Sawada M, Marusawa H, Chiba T
- Journal Title
  
  Oncogene 23
  
  Pages: 4921-4929
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004
- Author(s)
  Kanda N, Seno H, Chiba T, et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 4921-4929
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590589
[Presentation] RECK suppresses pancreatic cancer formation, epithelial-mesenchymal transition, and metastasis in mice2023
- Author(s)
  Tomonori Masuda, Akihisa Fukuda, Munenori Kawai, Go Yamakawa, Makoto Sono, Munemasa Nagao, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Tomoko Matsuzaki, Makoto Noda, Seno Hiroshi
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] In situ vaccine combining TLR9 nanoligand K3-SPG and nearinfrared photoimmunotherapy evokes potent antitumor immunity2023
- Author(s)
  Hiroaki Yaku, Ken Takahashi, Hirokazu Okada, Kouji Kobiyama, Keiko Iwaisako, Masataka Asagiri, Masahiro Shiokawa, Yuzo Kodama, Norimitsu Uza, Ken J. Ishii, Hiroshi Seno
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] PBRM1/VIMENTIN axis is a critical determinant for tumor grade and metastasis in Pancreatic cancer.2023
- Author(s)
  Munenori Kawai, Akihisa Fukuda, Yuki Nakanishi, Yukiko Hiramatsu, Makoto Sono, Tomonori Masuda, Mayuki Omatsu, Mio Namikawa, Go Yamakawa, Kosuke Iwane, Kenta Mizukoshi, Kei, Iimori, Shinnosuke Nakayama, Naoki Aoyama, Takahisa Maruno, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] MSH2は細胞周期を抑制することで肝癌の進行に抑制的に働くほか、脂質代謝にも影響を及ぼす2023
- Author(s)
  中野重治、髙井淳、上野真行、藤井洋佑、網野遥、伊藤卓彦、寺村茉利、三嶋眞紗子、井口恵里子、犬塚義、竹田治彦、清水孝洋、妹尾浩
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] THBS1による高悪性度大腸癌の微小環境制御機構の解明とその治療応用について2023
- Author(s)
  尾松万悠紀、中西祐貴、妹尾浩
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] PBRM1/VIMENTIN axis is a critical determinant for tumor grade and metastasis in Pancreatic cancer.2023
- Author(s)
  Munenori Kawai, Akihisa Fukuda, Yuki Nakanishi, Yukiko Hiramatsu, Makoto Sono, Tomonori Masuda, Mayuki Omatsu, Mio Namikawa, Go Yamakawa, Kosuke Iwane, Kenta Mizukoshi, Kei, Iimori, Shinnosuke Nakayama, Naoki Aoyama, Takahisa Maruno, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 小児炎症性腸疾患における抗インテグリンαVβ6抗体の意義2023
- Author(s)
  村本雄哉、塩川雅広、妹尾浩
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 同時性・異時性多発膵癌のクローン起源について2023
- Author(s)
  平野智紀、垣内伸之、竹内康英、増井俊彦、白石友一、宮野悟、宇座徳光、児玉裕三、増田充弘、田中雄志、妹尾浩、小川誠司
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] ARID1A has opposite functions in the conventional and serrated pathways in colon tumorigenesis.2023
- Author(s)
  Go Yamakawa, Akihisa Fukuda, Kosuke Iwane, Munenori Kawai, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Takahisa Maruno, Yuki Nakanishi, Yukiko Hiramatsu, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] 炎症性肝発癌過程におけるミスマッチ修復遺伝子MSH2の役割の解明2023
- Author(s)
  中野重治、髙井淳、上野真行、藤井洋佑、網野遥、伊藤卓彦、寺村茉利、三嶋眞紗子、井口恵里子、犬塚義、竹田治彦、清水孝洋、妹尾浩
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] THBS1 contributes to the creatoin of immunosuppressive microenvironment and promotes metastasis in colorectal cancer.2023
- Author(s)
  Mayuki Omatsu, Yuki Nakanishi, Kenta Mizukoshi, Kosuke Iwane, Munenori Kawai, Go Yamakawa, Mio Namikawa, Makoto Sono, Tomonori Masuda, Munemasa Nagao, Takahisa Maruno, Hiroaki Kasashima, Masakazu Yashiro, Akihisa Fukuda, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] THBS1による高悪性度大腸癌の微小環境制御機構の解明とその治療応用について2023
- Author(s)
  尾松万悠紀、中西祐貴、妹尾浩
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] RNA分解酵素Regnase-1は腸内細菌に起因するIL-17 signalingの制御を介して大腸腫瘍の発育を抑制する2023
- Author(s)
  井口恵里子、髙井淳、妹尾浩
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] 肝細胞癌は多段階発がんの各段階でどのような変異シグネチャーを有するか？2023
- Author(s)
  上野真行、竹田治彦、髙井淳、中野重治、波多野悦朗、妹尾浩
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] THBS1による高悪性度大腸癌の微小環境制御機構の解明とその治療応用について2023
- Author(s)
  尾松万悠紀、中西祐貴、妹尾浩
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] THBS1 contributes to the creatoin of immunosuppressive microenvironment and promotes metastasis in colorectal cancer.2023
- Author(s)
  Mayuki Omatsu, Yuki Nakanishi, Kenta Mizukoshi, Kosuke Iwane, Munenori Kawai, Go Yamakawa, Mio Namikawa, Makoto Sono, Tomonori Masuda, Munemasa Nagao, Takahisa Maruno, Hiroaki Kasashima, Masakazu Yashiro, Akihisa Fukuda, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] TERTの発現上昇はｐ21のユビキチン化を介して細胞増殖を促進し肝発癌に寄与する2023
- Author(s)
  三嶋眞紗子、竹田治彦、上野真行、中野重治、井口恵里子、清水孝洋、髙井淳、妹尾浩
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 膵癌オルガノイドにおけるERK MAPKシグナルの不均一性のライブイメージング2023
- Author(s)
  平塚徹、塚本祥子、アルコウサホウサム、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 腸上皮化生におけるDNAメチル化異常が胃発癌に与える影響2023
- Author(s)
  寺村茉利、清水孝洋、熊谷健、伊藤卓彦、網野遥、髙井淳、妹尾浩
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] RECKはEカドヘリンの発現を制御し，膵発癌，上皮間葉転換，転移を抑制する2023
- Author(s)
  益田朋典，福田晃久，河相宗矩, 薗誠, 丸野貴久, 妹尾浩
- Organizer
  第54回　日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] 臨床検体を用いた網羅的遺伝子解析による肝発癌初期のゲノム異常の解析2023
- Author(s)
  竹田治彦、髙井淳、妹尾浩
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 小児炎症性腸疾患における抗インテグリンαVβ6抗体の意義2023
- Author(s)
  村本雄哉、塩川雅広、妹尾浩
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] The functional role of Kras, p53, canonical Wnt and Notch pathways in the tumorigenesis of extrahepatic biliary system.2023
- Author(s)
  Munemasa Nagao, Akihisa Fukuada, Mio Namikawa, Kenta Mizukoshi, Shinnosuke Nakayama, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] Regnase-1 は Nfkbiz mRNA を分解し IL-17 signaling を制御することで大腸腫瘍の発育を抑制する2023
- Author(s)
  井口恵里子、髙井淳、妹尾浩
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] ARID1A has opposite functions in the conventional and serrated pathways in colon tumorigenesis.2023
- Author(s)
  Go Yamakawa, Akihisa Fukuda, Kosuke Iwane, Munenori Kawai, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Takahisa Maruno, Yuki Nakanishi, Yukiko Hiramatsu, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 臨床検体を用いた網羅的遺伝子解析による肝発癌初期のゲノム異常の解析2023
- Author(s)
  竹田治彦、髙井淳、妹尾浩
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] The functional role of Kras, p53, Wnt and Notch pathways in the tumorigenesis of extrahepatic biliary system.2023
- Author(s)
  Munemasa Nagao, Mio Namikawa, Yoko Masui, Chen Jiayu, Munehiro Ikeda, Sho Matsuyama, Kei Iimori, Shinnosuke Nakayama, Naoki Aoyama, Kenta Mizukoshi, Go Yamakawa, Keiske Iwane, Munenori Kawai, Mayuki Omatsu, Tomonori Masuda, Makoto Sono, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Akihisa Fukuda, Hiroshi Seno.
- Organizer
  第41回札幌国際がんシンポジウム
- Data Source
  KAKENHI-PROJECT-23K27582
[Presentation] The functional role of Kras, p53, canonical Wnt and Notch pathways in the tumorigenesis of extrahepatic biliary system.2023
- Author(s)
  Munemasa Nagao, Akihisa Fukuada, Mio Namikawa, Kenta Mizukoshi, Shinnosuke Nakayama, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Kras および WNT signaling の活性化により肝外胆管・胆嚢に前癌病変が形成され、胆道癌に進展する2022
- Author(s)
  長尾宗政、福田晃久、水越健太、岩根康祐、河相宗矩、山川剛、尾松万悠紀、並川実桜、薗誠、益田朋典、平松由紀子、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] 膵がんの上皮間葉転換・転移の制御因子2022
- Author(s)
  福田晃久、妹尾浩.
- Organizer
  第3回「医学と数理」ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-19H03639
[Presentation] Dual Loss of Arid1a and Pten in pancreatic ductal cells induces PDAC through activation of YAP/TAZ pathway.2022
- Author(s)
  Fukunaga Yuichi, Fukuda Akihisa, Tomonori Masuda, Sono Makoto, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi, Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Seno Hiroshi.
- Organizer
  The 7th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis.2022
- Author(s)
  Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi.
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Simultaneous activation of Notch and Kras pathways leads to biliary cancer via premalignant lesions through mTOR pathway2022
- Author(s)
  並川実桜、福田晃久、薗誠、益田朋典、長尾宗政、平松由紀子、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis.2022
- Author(s)
  Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Insights into initiation and progression of PDAC.2022
- Author(s)
  Akihisa Fukuda, Takahisa Maruno, Kyoichi Takaori, Hiroshi Seno
- Organizer
  American Pancreatic Association Annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Simultaneous activation of Notch and Kras pathways leads to biliary cancer via premalignant lesions through mTOR pathway2022
- Author(s)
  並川実桜、福田晃久、薗誠、益田朋典、長尾宗政、平松由紀子、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Kras および WNT signaling の活性化により肝外胆管・胆嚢に前癌病変が形成され、胆道癌に進展する2022
- Author(s)
  長尾宗政、福田晃久、水越健太、岩根康祐、河相宗矩、山川剛、尾松万悠紀、並川実桜、薗誠、益田朋典、平松由紀子、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Insights into initiation and progression of PDAC.2022
- Author(s)
  Akihisa Fukuda, Takahisa Maruno, Kyoichi Takaori, Hiroshi Seno
- Organizer
  American Pancreatic Association Annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] クロマチンリモデリング因子Brg1はマウス腸腫瘍およびヒト大腸癌の幹細胞性に重要な役割を果たす2022
- Author(s)
  吉川貴章、福田晃久、妹尾浩
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis in mice.2021
- Author(s)
  Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi.
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Bmi1 is required for pancreatic ductal adenocarcinoma formation through regulating PI3K/AKT pathway and acinar genes2021
- Author(s)
  Makoto Sono, Akihisa Fukuda, Tomonori Masuda, Yuichi Fukunaga, Takaaki Yoshikawa, Osamu Araki, Munemasa Nagao, Satoshi Ogawa, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis in mice.2021
- Author(s)
  Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi.
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION2021
- Author(s)
  小川智、福田晃久、妹尾浩
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION2021
- Author(s)
  小川智、福田晃久、妹尾浩
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Analysis of pancreato-biliary cancer development using mice and organoids2021
- Author(s)
  Hiroshi Seno, Munemasa Nagao, Yuichi Fukunaga, Satoshi Ogawa, Takahisa Maruno, Akihisa Fukuda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Analysis of pancreato-biliary cancer development using mice and organoids2021
- Author(s)
  Hiroshi Seno, Munemasa Nagao, Yuichi Fukunaga, Satoshi Ogawa, Takahisa Maruno, Akihisa Fukuda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Simultaneous loss of Arid1a and Pten in pancreatic ductal cells induces ITPN and PDAC through activation of YAP/TAZ2021
- Author(s)
  福永裕一、福田晃久、薗誠、益田朋典、吉川貴章、荒木理、長尾宗政、平松由紀子、小川智、丸野貴久、中西佑貴、鶴山竜昭、妹尾浩
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] クロマチン制御因子Brg1は膵癌の増大・転移に重要である2021
- Author(s)
  荒木理、福田晃久、妹尾浩
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] Bmi1 is required for pancreatic ductal adenocarcinoma formation through regulating PI3K/AKT pathway and acinar genes2021
- Author(s)
  Makoto Sono, Akihisa Fukuda, Tomonori Masuda, Yuichi Fukunaga, Takaaki Yoshikawa, Osamu Araki, Munemasa Nagao, Satoshi Ogawa, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] 多段階発癌におけるミスマッチ修復異常関連体細胞変異シグネチャーの抽出2021
- Author(s)
  竹田治彦、高井淳、恵荘裕嗣、高橋健、田浦康二朗、波多野悦朗、喜多竜一、丸澤宏之、藤本明洋、妹尾浩
- Organizer
  第24回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-21K19480
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫，幽門腺形質をもつBilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、妹尾浩
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Setdb1 deletion protects against formation of pancreatic ductal adenocarcinoma by inducing p53-mediated apoptosis.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Intestinal tumor stem cell specific ablation of Brg1 resulted in reduction of intestinal tumors with increased apoptosis.2020
- Author(s)
  Takaaki Yoshikawa, Akihisa Fukuda, Hiroshi Seno.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  51st Annual Meeting of the American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Brg1, a subunit of the SWI/SNF complex, is critical for growth and metastasis of pancreatic cancer cells in mice.2020
- Author(s)
  Osamu Araki, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  51st Annual Meeting of the American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Bmi1 is required for pancreatic cancer formation through regulating PI3K/AKT pathway in mice.2020
- Author(s)
  Sono Makoto, Fukuda Akihisa, Tsuda Motoyuki, Seno Hiroshi
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] Setdb1 deletion protects against formation of pancreatic ductal adenocarcinoma by inducing p53-mediated apoptosis.2020
- Author(s)
  Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Brg1, a subunit of the SWI/SNF complex, is critical for growth and metastasis of pancreatic cancer cells in mice.2020
- Author(s)
  Osamu Araki, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Intestinal tumor stem cell specific ablation of Brg1 resulted in reduction of intestinal tumors with increased apoptosis.2020
- Author(s)
  Takaaki Yoshikawa, Akihisa Fukuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Bmi1 is required for pancreatic cancer formation through regulating PI3K/AKT pathway in mice.2020
- Author(s)
  Makoto Sono, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫，幽門腺形質をもつBilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、妹尾浩
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] 潰瘍性大腸炎における大腸上皮細胞のクローン進化と発がん2020
- Author(s)
  垣内伸之, 妹尾浩, 小川誠司
- Organizer
  第62回日本消化器病学会大会(JDDW2020)
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫BilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、尾松万悠紀、並川実桜、薗誠、福永裕一、益田朋典、荒木理、吉川貴章、小川智、平松由紀子、津田喬之、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03659
[Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫BilINの形成に重要である2020
- Author(s)
  長尾宗政、福田晃久、尾松万悠紀、並川実桜、薗誠、福永裕一、益田朋典、荒木理、吉川貴章、小川智、平松由紀子、津田喬之、丸野貴久、中西祐貴、妹尾浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] The role of tuft cell-like tumor/cancer cells in intestinal tumors.2019
- Author(s)
  妹尾浩、後藤規弘、福田晃久
- Organizer
  第78回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The role of tuft cell-like tumor/cancer cells in intestinal tumors.2019
- Author(s)
  妹尾浩、後藤規弘、福田晃久
- Organizer
  第78回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22619
[Presentation] Essential role of Arid1a in intestinal stem cell maintenance and homeostasis through Sox9 regulation.2018
- Author(s)
  Yukio Hiramatsu, Akihisa Fukuda, Hiroshi Seno
- Organizer
  GI Research Academy 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] 腸管の正常幹細胞と腫瘍幹細胞におけるHes1の役割2018
- Author(s)
  後藤規弘、福田晃久、妹尾浩
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The functional role of Eset in exocrine pancreatic regeneration and pancreatic cancer initiation2018
- Author(s)
  小川智、福田晃久、津田喬之、後藤規弘、平松由紀子、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] Sox9制御を介した腸幹細胞、腸恒常性維持におけるArid1aの役割について2018
- Author(s)
  平松由紀子、福田晃久、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.2018
- Author(s)
  津田喬之、福田晃久、妹尾浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] 代謝、炎症、発癌を制御する因子Nardilysinの可能性2017
- Author(s)
  生田耕三、福田晃久、妹尾浩
- Organizer
  第103回日本消化器病学会総会内第1回消化器臓器間ネットワーク附置研究会
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] 膵がん形成過程における可塑性と幹細胞性2017
- Author(s)
  妹尾浩、丸野貴久、後藤規弘、津田喬之、木村佳人、福田晃久
- Organizer
  第76回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] BRG1はSox9の発現制御を介しPanINの形成・維持に重要な役割をはたす2017
- Author(s)
  津田喬之、福田晃久、妹尾
- Organizer
  JDDW 2017
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Brg1 plays a critical role in PanIN formation through regulating Sox9 expression.2017
- Author(s)
  Motoyuki Tsuda, Akihisa Fukuda, Takahisa Maruno, Haruhiko Akiyama, Kyoichi Takaori, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno, et al.
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] Nrdc inhibtits Kras-driven pancreatic tumorigenesis through suppressing spontaneous pancreatitis2017
- Author(s)
  Kozo Ikuta,Akihisa Fukuda,Tomoyuki Tsuda,Takahisa Maruno,Keitaro Kanda,Eiichiro Nishi,Hiroshi Seno
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Nardilysin functions as a tumor suppressor in pancreatic ductal adenocarcinoma through maintaining acinar cell differentiation and suppressing pancreatitis2017
- Author(s)
  Kozo Ikuta, Akihisa Fukuda, Hiroshi Seno
- Organizer
  JDDW 2017
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] EpCAM陽性肝幹/前駆細胞を起源とした肝発癌の分子機構2017
- Author(s)
  松本知訓、妹尾浩、丸澤宏之
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The role of Hes1 in the normal and tumor stem cells of the intestine.2017
- Author(s)
  Norihiro Goto, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] The role of Hes1 in the normal and tumor stem cells of the intestine.2017
- Author(s)
  Norihiro Goto, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Nardilysin functions as a tumor suppressor in pancreatic ductal adenocarcinoma through maintaining acinar cell differentiation and suppressing pancreatitis.2017
- Author(s)
  Kozo Ikuta, Akihisa Fukuda, Eiichiro Nishi, Hiroshi Seno, et al.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04157
[Presentation] Brg1 plays an important role in acinar cell-derived PanIN formation through regulation of SOX9 expression.2016
- Author(s)
  Tsuda M, Fukuda A, Chiba T, Seno H.
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] Cell of origin and tumor stem cells in mouse digestive organ tumors.2016
- Author(s)
  Seno H
- Organizer
  The 47th Princess Takamatsu Cancer Research Funf International Symposia
- Place of Presentation
  Tokyo, Palace Hotel Tokyo
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Hierarchy in mouse digestive organ tumors.2016
- Author(s)
  妹尾浩、丸野貴久、津田喬之、福田晃久
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] クロマチンリモデリング因子Ｂrg１はIＰＭＮおよびIPMN由来膵癌の発生を抑制する2016
- Author(s)
  Fukuda A, Chiba T, Seno H
- Organizer
  第20回分子標的治療学会学術集会
- Place of Presentation
  別府
- Year and Date
  2016-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-25461021
[Presentation] 消化器腫瘍における腫瘍幹細胞標的治療2016
- Author(s)
  妹尾浩、丸野貴久、後藤規弘、福田晃久
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Role of Dclk1-expressing cells in digestive organs.2016
- Author(s)
  Seno H, Maruno T, Fukuda A.
- Organizer
  The 41st Naito Conference
- Place of Presentation
  Sapporo, Chateraise Gateaux Kingdom
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 消化器腫瘍における腫瘍幹細胞標的治療2016
- Author(s)
  妹尾浩、丸野貴久、後藤規弘、福田晃久
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-16K15427
[Presentation] 消化器臓器における腫瘍幹細胞の役割2015
- Author(s)
  妹尾浩
- Organizer
  第4回Cancer Stem Cell Symposium
- Place of Presentation
  福岡市
- Year and Date
  2015-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Microarray analysis of Dclk1-positive tumor cells in ApcMin/+ mouse polyps.2015
- Author(s)
  Yamaga Y, Seno H, Chiba T.
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 細胞系譜解析を用いた消化器腫瘍幹細胞の検討2015
- Author(s)
  妹尾浩
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Targeting tumor stem cells in the intestine.2015
- Author(s)
  Seno H, Yamaga Y, Matsumoto Y, Nakanishi Y, Fukuda A, Chiba T.
- Organizer
  The 3rd JSGE International Topic Conference
- Place of Presentation
  仙台市
- Year and Date
  2015-04-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Cell of origin and complexity in digestive organ tumors.2015
- Author(s)
  妹尾浩、福田晃久、丸野貴久、後藤規弘、千葉勉
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Tumor stem cells in digestive organs2015
- Author(s)
  Seno H
- Organizer
  2nd IFOM-Kyoto University Joint Symposium.
- Place of Presentation
  京都市
- Year and Date
  2015-10-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 消化器腫瘍モデルにおけるDCLK1陽性細胞の意義2015
- Author(s)
  妹尾浩
- Organizer
  平成26年度がん研究分野の特性等を踏まえた支援活動冬期公開シンポジウム
- Place of Presentation
  東京都千代田区
- Year and Date
  2015-01-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] The role of Dclk1-positive cells in digestive organ tumors.2014
- Author(s)
  Seno H
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都府京都市
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] The role of Dclk1-positive cells in digestive organ tumors.2014
- Author(s)
  Seno H
- Organizer
  4th Global Cancer Genomics Consortium
- Place of Presentation
  京都府京都市
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] Dclk1, a specific marker for tumor stem cells in digestive organs.2014
- Author(s)
  妹尾浩、中西祐貴、千葉勉
- Organizer
  第52回日本癌治療学会学術集会　高松宮妃癌研究基金共催国際シンポジウム
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] Role of Dclk1-expressing cells in digestive organ tumors.2014
- Author(s)
  妹尾浩、丸野貴久、山賀雄一、吉岡拓人、中西祐貴、千葉勉
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-26293173
[Presentation] 腸腫瘍幹細胞特異的マーカーDclk1の同定2013
- Author(s)
  中西祐貴、上尾太郎、妹尾浩
- Organizer
  International Sessionsがん幹細胞第72回日本癌学会総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Intestinal tumors are continuously renewed by Dclk1-positive tumor stem cells2013
- Author(s)
  Nakanishi Y, Seno H, Chiba T.
- Organizer
  American Association of Cancer Research, Annual Meeting 2013
- Place of Presentation
  Washington DC, USA, Walter E. Washington Convention Center
- Year and Date
  2013-04-10
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 正常腸管および腸腫瘍におけるDclk1/Lgr5陽性細胞の役割2013
- Author(s)
  中西祐貴, 妹尾浩, 上尾太郎
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島かごしま県民交流センター
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Nardilysin promotes gastric cancer growth by activating intrinsic cytokine signaling2013
- Author(s)
  Kanda K, Kimura Y, Yoshioka T, Seno H, Chiba T
- Organizer
  The 4th JCA-AACR Special Joint Conference
- Place of Presentation
  東京ベイ舞浜ホテル（千葉県浦安市）
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] 正常腸管および腸腫瘍におけるDclk1/Lgr5陽性細胞の役割2013
- Author(s)
  中西祐貴、妹尾浩、上尾太郎
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島かごしま県民交流センター
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine.シンポジウムがん幹細胞研究に基づく新たながん治療戦略2013
- Author(s)
  妹尾浩, 中西祐貴, 千葉勉
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸神戸国際会議場
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine2013
- Author(s)
  妹尾浩、中西祐貴、千葉勉
- Organizer
  シンポジウムがん幹細胞研究に基づく新たながん治療戦略第36回日本分子生物学会年会
- Place of Presentation
  神戸神戸国際会議場
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Intestinal tumors are continuously renewed by Dclk1-positive tumor stem cells2013
- Author(s)
  Nakanishi Y, Seno H, Chiba T
- Organizer
  American Association of Cancer Research, Annual Meeting 2013
- Place of Presentation
  Washington DC, USA, Walter E. Washington Convention Center
- Year and Date
  2013-04-10
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] 腸腫瘍幹細胞特異的マーカーDclk1の同定. International Sessionsがん幹細胞2013
- Author(s)
  中西祐貴, 上尾太郎, 妹尾浩
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Hes1は大腸上皮細胞の位置を規定し、ニッチ由来のWntやBMPシグナルによる分化制御に関与する2012
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 腸腫瘍幹細胞特異的マーカーDcamkl1の同定2012
- Author(s)
  中西祐貴, 上尾太郎, 妹尾浩
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine2012
- Author(s)
  Seno H
- Organizer
  GI Research Academy 2012
- Place of Presentation
  Tokyo, Japan, Keidanren Hall
- Year and Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Hes1は大腸上皮細胞の位置を規定し, ニッチ由来のWntやBMPシグナルによる分化制御に関与する2012
- Author(s)
  上尾太郎, 妹尾浩, 仲瀬裕志:
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] The role of Dclk1-positive cells in the intestinal homeostasis2012
- Author(s)
  Nakanishi Y, Seno H, Ueo T, Chiba T
- Organizer
  2012 James W. Freston Single Topic Conference : Gastrointestinal Stem Cell Biology and Pathobiology
- Place of Presentation
  Chicago, USA, Intercontinental Hotel Chicago
- Year and Date
  2012-08-27
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] The role of Dclk1-positive cells in the intestinal homeostasis. 2012 James W. Freston Single Topic Conference2012
- Author(s)
  Nakanishi Y, Seno H, Ueo T, Chiba T.
- Organizer
  Gastrointestinal Stem Cell Biology and Pathobiology
- Place of Presentation
  Chicago, USA, Intercontinental Hotel Chicago
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 腸腫瘍幹細胞特異的マーカーDcamkl1の同定2012
- Author(s)
  中西祐貴、上尾太郎、妹尾浩
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Dclk1 discriminates between tumor and normal stem cells in the intestine2012
- Author(s)
  Seno H.
- Organizer
  GI Research Academy 2012
- Place of Presentation
  Tokyo, Japan, Keidanren Hall
- Year and Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] ナルディライジンはTNF-αのシェディングを促進し内因性サイトカインシグナル経路を活性化して胃癌細胞の増殖を制御する2011
- Author(s)
  神田啓太郎、米門秀行、妹尾浩、千葉勉、西英一郎
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23590937
[Presentation] Hes not only regulates the proliferation and differentiation of colon stem cell but also keep stem cells at correct position.2010
- Author(s)
  Ueo T, Seno H, Nakase H
- Organizer
  1st International Topic Conference.
- Place of Presentation
  Kamakura, Japan
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes not only regulates the proliferation and differentiation of colon stem cell but also keep stem cells at correct position.2010
- Author(s)
  Ueo T, Seno H, et al.
- Organizer
  International Topic Conference
- Place of Presentation
  Kamakura
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes1は大腸腫瘍の増殖や未分化性の維持に重要である2010
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes1は大腸腫瘍の増殖や未分化能の維持に重要である2010
- Author(s)
  上尾太郎, 妹尾浩, 他
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] ナルディライジンによるIL-6/Stat3シグナルを介した胃癌細胞の増殖制御2010
- Author(s)
  神田啓太郎、米門秀行、妹尾浩、千葉勉、西英一郎
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Hes1は、大腸上皮幹細胞の分化や増殖を制御し、さらに幹細胞の位置や陰窩の形態保持に関与している2010
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] 消化管上皮ならび腫瘍におけるHesの役割2009
- Author(s)
  上尾太郎、妹尾浩、仲瀬裕志
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] Efficient colonic mucosal wound repair requires Trem2-dependent alternative activation of macrophages.2009
- Author(s)
  Seno H.
- Organizer
  US-Japan GI Executive Meeting.
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] マウス内視鏡を用いた新規大腸粘膜障害・再生モデルの検討2009
- Author(s)
  秋武玲子、神田啓太郎、米門秀行、河田真由美、妹尾浩、千葉勉
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20599008
[Presentation] The role of Nardilysin in intestinal tumorigenesis
- Author(s)
  Seno H, Kanda K, Nishi E, Chiba T
- Organizer
  GI Research Academy 2013
- Place of Presentation
  京都グランヴィアホテル（京都府京都市）
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] 腸腫瘍微小環境におけるナルディライジンの役割
- Author(s)
  妹尾　浩、神田啓太郎、千葉　勉
- Organizer
  平成25年度文部科学省新学術領域研究　がん研究分野の特性等を踏まえた支援活動　公開シンポジウム
- Place of Presentation
  一橋講堂(東京)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] Identification of a pancreatic tumor specific stem cell marker.
- Author(s)
  Takahisa Maruno, Akihisa Fukuda, Hiroshi Seno, Tsutomu　Chiba.
- Organizer
  第73回日本癌学会学術総会 2014　東京.
- Place of Presentation
  東京
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25461021
[Presentation] Nardilysin promotes gastric cancer growth by activating intrinsic cytokine signaling
- Author(s)
  Keitaro Kanda, Yuto Kimura, Takuto Yoshioka, Hiroshi Seno, Tsutomu Chiba
- Organizer
  The4th JCA-AACR Special conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club & Resorts(Urayasu)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] The role of nardilysin in intestinal tumorigenesis
- Author(s)
  Hiroshi Seno, Keitaro Kanda, Ei-ichiro Nishi, Tsutomu Chiba
- Organizer
  GI Research Academy 2013
- Place of Presentation
  Hotel Granvia Kyoto(Kyoto)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] The role of Nardilysin in intestinal tumorigenesis.
- Author(s)
  Seno H, Kanda K, Nishi E, Chiba T.
- Organizer
  The 4th symposium on TGF-beta family and cancer.
- Place of Presentation
  茨城県つくば市
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling
- Author(s)
  Chiba T, Kanda K, Seno H, Nishi E
- Organizer
  Singapore Gastric Cancer Consortium, 6th Annual Scientific Meeting
- Place of Presentation
  NUHS Tower Block Auditorium (Singapore)
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112707
[Presentation] Identification of Dclk1 as aspecific tumor stem cell marker in the intestine　腸腫瘍幹細胞マーカーDclk1の同定
- Author(s)
  中西祐貴、妹尾　浩、上尾太郎、千葉　勉
- Organizer
  第72回日本癌学会学術集会・International Sessions
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-24659363
[Presentation] 腫瘍肝細胞による腫瘍組織構築機構の検討
- Author(s)
  中西祐貴、妹尾　浩、千葉　勉
- Organizer
  第50回日本臨床分子医学会学術集会・学術奨励賞
- Place of Presentation
  東京国際フォーラム(東京)
- Data Source
  KAKENHI-PROJECT-24659363

1. FUKUDA Akihisa (70644897)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. 中西祐貴 (40838679)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
3. MINAMI Manabu (90511907)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Tanaka Motomu (00706814)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. CHIBA Tsutomu (30188487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. NABESHIMA Motoshige (80314178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYAMOTO Shinichi (90378761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Kodama Yuzo (80378687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Kakiuchi Nobuyuki (90839721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 澤田光孝 (70235472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 塩川雅広 (50737880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 増田充弘 (60512530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高島義徳 (40379277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 浦山健治 (20263147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKATSUJI Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YASUI Mika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. FUJIKAWA Risako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HIGUCHI Sei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUKUMITSU Ryu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. IKEDO Taichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAGATA Manabu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HAYASHI Kosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MIYATA Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. YANG Tao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MASUI Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. KOMEKADO Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. ISHII Takamichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. KURIYAMA Katsutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 本澤有介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 影山龍一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 寺倉精太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 横出正之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 松本久子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 清水孝洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 並川実桜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 大橋真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 長井和之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 高石繁生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 高井淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
40. 山田洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 上本伸二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 大野美紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 子安翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 波多野悦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 福光剣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 小木曾聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 小杉眞司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 恵荘裕嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 笠島裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 西英一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 長澤丘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seno Hiroshi 妹尾 浩

SENO Hiroshi 妹尾 浩

妹尾 浩 セノオ ヒロシ

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大腸がん幹細胞の可塑性を制御する時空間的メカニズムの解析Principal Investigator

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Strategies to prevent progression from premalignant lesion to cancer in the pancreasPrincipal Investigator

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Novel therapeutic strategy against colorectal cancer by intervening fluctuated differentiation statusPrincipal Investigator

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Live imaging of human pancreatic cancer stem cell dynamicsPrincipal Investigator

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Therapeutic strategy against gastrointestinal cancer by utilizing cancer hierarchyPrincipal Investigator

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Nrd1 as a novel therapeutic target against colorectal cancerPrincipal Investigator

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Seno Hiroshi 妹尾浩

SENO Hiroshi 妹尾浩

妹尾浩セノオヒロシ