YOSHIHARA Hiroki 吉原宏樹

Researcher Number	90348706
Affiliation (based on the past Project Information) *help	2012: 慶應義塾大学, 医学部, その他 2010 – 2012: 慶應義塾大学, 医学部, 共同研究員 2011: 慶應義塾大学, 政策メディア研究科, 助教 2010: Keio University, 政策・メディア研究科, 助教 2009: Keio University, 政策・メディア研究科, 研究員 2008: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Pediatrics / Applied genomics / Biological Sciences
Keywords	Principal Investigator プロテオーム / 移植・再生医療 Except Principal Investigator 白血病 / リン酸化 / プロテオーム / 生体分子 / 癌 / 小児腫瘍学 / インタラクトーム / リン酸化プロテオミクス … More / キナーゼ / リン酸化プロテオーム / 翻訳後修飾 / TIE2受容体 / thrombopoietin / mpl / TIE2 / Angiopoiedn-1 / ATM / Thrombopoietin / Mpl / 活性酸素 / Angiopoietin-1 / Tie2 / 自己複製能 / 骨芽細胞 / ニッチ / 造血幹細胞 Less

Proteomic analysis of phosphorylation in leukemic cells
- Principal Investigator
  
  SHIMADA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Interactome analysis of protein kinases
- Principal Investigator
  
  ISHIHAMA Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied genomics
- Research Institution
  Kyoto University
  Keio University
Control of the HSC Niche Signaling for the Efficient Long-Term Engraftment of Hematopoietic Stem Cells without Irradiation or High-Dose ChemotherapyPrincipal Investigator
- Principal Investigator
  
  YOSHIHARA Hiroki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Regulation of Hematopoietic Stem Cell Division in a Niche
- Principal Investigator
  
  SUDA Toshio
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University

All 2011 2010 2009 2007

All Journal Article Presentation Book

[Book] 病理と臨床特集「プロテオミクス-病理との関わり-」2010
- Author(s)
  吉原宏樹, 石濱泰
- Total Pages
  100
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-21310129
[Book] 病理と臨床特集「プロテオミクス-病理との関わり-」2010
- Author(s)
  吉原宏樹, 石濱泰
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-21310129
[Book] Annual Review血液2010「生体内における造血幹細胞の動態」2010
- Author(s)
  吉原宏樹、須田年生
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] リン酸化タンパク質の網羅的解析2010
- Author(s)
  吉原宏樹
- Journal Title
  
  病理と臨床
  
  Volume: 28 Pages: 512-517
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] リン酸化タンパク質の網羅的解析2010
- Author(s)
  吉原宏樹、石濱泰
- Journal Title
  
  病理と臨床 28(5)
  
  Pages: 512-517
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.2010
- Author(s)
  Gomei Y, Nakamura Y, Yoshihara H, Hosokawa K, Iwasaki H, Suda T, Arai F.
- Journal Title
  
  Exp Hematol 38(2)
  
  Pages: 82-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.2010
- Author(s)
  Nakamura Y, Arai F, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T.
- Journal Title
  
  Blood. 116(9)
  
  Pages: 1422-1432
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.2010
- Author(s)
  Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T.
- Journal Title
  
  Blood. 116(4)
  
  Pages: 554-563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow.2010
- Author(s)
  Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura Y, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T.
- Journal Title
  
  Cell Stem Cell 6(3)
  
  Pages: 194-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] IRF-2 protects quiescent HSCs from type-I interferon-dependent exhaustion.2009
- Author(s)
  Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T.
- Journal Title
  
  Nature Medicine 15(6)
  
  Pages: 696-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] Niche regulation of hematopoietic stem cells in the endosteum.2009
- Author(s)
  Arai F, Yoshihara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Suda T.
- Journal Title
  
  Ann N Y Acad Sci 1176
  
  Pages: 36-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791003
[Journal Article] Thrombopoietin/Mpl signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche2007
- Author(s)
  Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyazaki H, Takahashi T, Suda T
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 685-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Thrombopoietin/Mpl signaling regulates hematopoietic stem ceU quiescence and interaction with Ihe osteoblastic niche.2007
- Author(s)
  Yoshihara H, et. al.
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 685-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Presentation] 微量組織試料に対する定量的リン酸化プロテオーム解析法の確立2011
- Author(s)
  若林真樹; 塚原麻伊; 吉原宏樹; 増田豪; 石濱泰
- Organizer
  日本プロテオーム学会2011年会
- Place of Presentation
  朱鷺メッセ(新潟県)
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21310129
[Presentation] Phosphoproteomic profiling of leukemia cells2010
- Author(s)
  Yoshihara H, Shimada H, Shima H, Tomita M, Ishihama Y
- Organizer
  15th European Hematology Association congress
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-22591168
[Presentation] リン酸化プロテオーム解析を用いた分子標的薬のin vivoプロファイリング2010
- Author(s)
  杉山直幸, 京野完, 吉原宏樹, 今見考志, 大沼澄子, 塚原麻伊, 冨田勝, 石濱泰
- Organizer
  日本ヒトプロテオーム機構第8回大会-第6回日本臨床プロテオーム研究会連合大会
- Place of Presentation
  東京ベイホテル東急(浦安)
- Year and Date
  2010-07-26
- Data Source
  KAKENHI-PROJECT-21310129
[Presentation] Phosphoproteomic Profiling of Leukemia Cells. Session Type : Poster Session.2010
- Author(s)
  Yoshihara H, Shimada H, Shima H, Tomita M, Ishihama Y.
- Organizer
  15th Congress of the European Hematology Association
- Place of Presentation
  Barcelona, Spain.
- Data Source
  KAKENHI-PROJECT-21791003
[Presentation] ホルマリン処理パラフィン包埋切片のリン酸化プロテオーム解析2010
- Author(s)
  吉原宏樹, 冨田勝, 石濱泰
- Organizer
  日本ヒトプロテオーム機構第8回大会-第6回日本臨床プロテオーム研究会連合大会
- Place of Presentation
  東京ベイホテル東急(浦安)
- Year and Date
  2010-07-26
- Data Source
  KAKENHI-PROJECT-21310129
[Presentation] PHOSPHOPROTEOMIC PROFILING OF LEUKEMIA CELLS2010
- Author(s)
  吉原宏樹
- Organizer
  15th European Hematology Association congress
- Place of Presentation
  バルセロナ
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-22591168
[Presentation] Phosphoproteomic Profiling of Leukemia Cells2010
- Author(s)
  吉原宏樹
- Organizer
  15th Congress of the European Hematology Association
- Place of Presentation
  バルセロナ、スペイン
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-21791003

1. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. SUDA Toshio (60118453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. ARAI Fumio (90365403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MIYAMOTO Takeshi (70383768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUOKA Sahoko (20317340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. TAKUBO Keiyo (50502788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NAGAMATSU Go (70453545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGIYAMA Naoyuki (50545704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MASUDA Takeshi (70383940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. SHIMADA Hiroyuki (80265868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SHIMA Haruko (80424167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KITABAYASHI Kazuo (20261175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIHARA Hiroki 吉原 宏樹

Research Projects

Research Products

Co-Researchers

Proteomic analysis of phosphorylation in leukemic cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interactome analysis of protein kinases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control of the HSC Niche Signaling for the Efficient Long-Term Engraftment of Hematopoietic Stem Cells without Irradiation or High-Dose ChemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of Hematopoietic Stem Cell Division in a Niche

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 病理と臨床 特集「プロテオミクス-病理との関わり-」2010

Author(s)

Total Pages

Publisher

Data Source

[Book] 病理と臨床特集「プロテオミクス-病理との関わり-」2010

Author(s)

Publisher

Data Source

[Book] Annual Review血液2010「生体内における造血幹細胞の動態」2010

Author(s)

Publisher

Data Source

[Journal Article] リン酸化タンパク質の網羅的解析2010

Author(s)

Journal Title

Data Source

[Journal Article] リン酸化タンパク質の網羅的解析2010

Author(s)

Journal Title

Data Source

[Journal Article] Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow.2010

Author(s)

Journal Title

Data Source

[Journal Article] IRF-2 protects quiescent HSCs from type-I interferon-dependent exhaustion.2009

Author(s)

Journal Title

Data Source

[Journal Article] Niche regulation of hematopoietic stem cells in the endosteum.2009

Author(s)

Journal Title

Data Source

[Journal Article] Thrombopoietin/Mpl signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche2007

Author(s)

Journal Title

Data Source

[Journal Article] Thrombopoietin/Mpl signaling regulates hematopoietic stem ceU quiescence and interaction with Ihe osteoblastic niche.2007

Author(s)

Journal Title

YOSHIHARA Hiroki 吉原宏樹

[Book] 病理と臨床特集「プロテオミクス-病理との関わり-」2010