Saito Takashi 斉藤貴志

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SAITO Takashi 斉藤貴志

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Researcher Number	90360552
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 名古屋市立大学, 医薬学総合研究院(医学), 教授 2015 – 2016: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2013 – 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2011 – 2012: 独立行政法人理化学研究所, 神経蛋白制御研究チーム, 副チームリーダー 2008 – 2010: The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, 研究員 2003 – 2006: 独立行政法人理化学研究所, 神経蛋白制御研究チーム, 研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Drug development chemistry Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 90120:Biomaterials-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator アルツハイマー病 / アミロイドβ / アミロイドβペプチド / モデルマウス / ネプリライシン / ケモカイン / タウ / グリア応答 / トランスレーショナルリサーチ / ノックインマウス … More / プレセニリン1(PS1) / アミロイドβペプチド(Aβ) / ソマトスタチン / グリア / アミロイド病理 / 神経炎症 / 認知症 / モデル動物 / 老化 / 脳神経疾患 / 痴呆 / 蛋白質代謝 / 脳老化 / アミロイド前駆体タンパク / 早期診断 / フォスファターゼ / 創薬 / MAPK / 神経栄養因子 / プレセニリン-1 / アミロイド前駆体蛋白(APP) / アミロイド前駆体蛋白質(APP) / プレセニリン1 / アミロイド前駆体蛋白 / ソマトスタチン受容体 / プレシナプス / ソマトスタチン受容体4 / 神経ペプチド … More Except Principal Investigator アルツハイマー病 / 慢性腎臓病 / 遺伝子改変マウス / マクロファージ / エピジェネティクス / 炎症メモリー / マルチステップ作用 / コレステロール / アミロイドβペプチド / siRNA複合体 / 脳アミロイドーシス / ゲノム編集 / 脳移行 / ドラッグデリバリーシステム / siRNA / 脳移行性リガンド / 結合体 / シクロデキストリン / デンドリマー / 血液脳関門 / 多段階作用 / 神経変性疾患 / 脳脊髄液 / 輸送 / 細胞外小胞 / 排出輸送 / 血液くも膜関門 Less

Understanding and regulation of non-inflammatory glial responses in the pathogenesis of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  斉藤貴志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya City University
Development of novel therapeutic strategies of chronic inflammatory diseases by using inflammatory memory cell visualizing mouse
- Principal Investigator
  
  古賀友紹
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kumamoto University
Elucidation of chemokine cross-talk underlying pathogenesis of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Saito Takashi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya City University
Development of innovative drugs having multistep action for treatment of central cerebral amyloidosis
- Principal Investigator
  
  Hidetoshi Arima
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system
- Principal Investigator
  
  TACHIKAWA Masanori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokushima
Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Saito Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Institute of Physical and Chemical Research
Establishment of the diagnostics of Alzheimer' s disease using A・43Principal Investigator
- Principal Investigator
  
  SAITO Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
Establishment and application of novel type of Alzheimer's disease model mousePrincipal Investigator
- Principal Investigator
  
  SAITO Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
ネプリライシンを中軸とするアルツハイマー病予防・治療のための創薬標的の探索Principal Investigator
- Principal Investigator
  
  斉藤貴志
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The Institute of Physical and Chemical Research
Generation and application of the novel mouse model for Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  SAITO Takashi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
ソマトスタチンによるアミロイドβ分解酵素ネプリライシンの活性制御機構の解明Principal Investigator
- Principal Investigator
  
  斉藤貴志
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
アミロイドβ分解酵素ネプリライシンの発現及び活性制御機構の解明Principal Investigator
- Principal Investigator
  
  斉藤貴志
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Chronic Inflammation-Mechanisms and Regulation2016
- Author(s)
  Takashi Saito
- Total Pages
  11
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] Inflammasome signaling is dispensable for β-amyloid-induced neuropathology in preclinical models of Alzheimer’s disease2024
- Author(s)
  Srinivasan S, Kancheva D、De Ren S, Saito T, et al
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 1323409-1323409
- DOI
  10.3389/fimmu.2024.1323409
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03564, KAKENHI-PROJECT-23K26790
[Journal Article] Multifactorial glial responses and their contributions to Alzheimer's disease continuum2023
- Author(s)
  Hijioka Masanori, Manabe Tatsuya, Saito Takashi
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: - Issue: 2 Pages: 1-10
- DOI
  10.1111/cen3.12745
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06865, KAKENHI-PROJECT-22K20688, KAKENHI-PROJECT-20H03564
[Journal Article] Recent advances in the modeling of Alzheimer’s disease.2022
- Author(s)
  Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, Ohshima T, Yoshiki A, Sato K, Kumita W, Sasaki E, Kitazume S, Nilsson P, Winblad B, *Saito T, *Iwata N, *Saido TC
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 8074743-8074743
- DOI
  10.3389/fnins.2022.807473
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03564, KAKENHI-PROJECT-21K15378, KAKENHI-PROJECT-21H02831
[Journal Article] PLD3 gene and processing of APP2017
- Author(s)
  P. Fazzari, K. Horre, A.M. Arranz, C.S. Frigerio, T. Saito, T.C. Saido and B. De Strooper
- Journal Title
  
  Nature
  
  Volume: 541 Issue: 7638 Pages: E1-E2
- DOI
  10.1038/nature21030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targetting by the ACSA-2 antibody.2017
- Author(s)
  M.Y. Batiuk, F. de Vin, S.I. Duqué, C. Li, T. Saito, T.C. Saido, M. Fiers, T.G. Belgard , M.G. Holt
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Issue: 21 Pages: 8874-8891
- DOI
  10.1074/jbc.m116.765313
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] Tetraspanin 6: a pivotal protein of the Multiple Vesicular Body determining exosome release and lysosomal degradation of Amyloid Precursor protein fragments.2017
- Author(s)
  F.X. Guix, R. Sannerud, F. Berditchevski, A. Arranz, K. Horré, A. Snellinx, A. Thathiah, T. Saito, T Saido, R. Sundaresan, M. Overduin, S. Kumar-Singh, E. Radaelli, N. Corthout, J. Colombelli, S. Tosi, S. Munck, I.H. Salas,W. Annaert, B. De Strooper
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Issue: 1 Pages: 25-25
- DOI
  10.1186/s13024-017-0165-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease2016
- Author(s)
  Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., Matsumi, C., Kajikawa, M., Saito, T., Saido, T., Sobue, G., Miyawaki, A., Okazawa, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 31895-31895
- DOI
  10.1038/srep31895
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-26290019, KAKENHI-PROJECT-15K15338, KAKENHI-PROJECT-16K07040
[Journal Article] Familial Alzheimer disease mutations in presenilin generate amyloidogenic Abeta peptide seeds.2016
- Author(s)
  S. Veugelen, T. Saito, T.C. Saido, L. Chávez-Gutiérrez, and B. De Strooper
- Journal Title
  
  Neuron
  
  Volume: 90 Issue: 2 Pages: 410-416
- DOI
  10.1016/j.neuron.2016.03.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions2016
- Author(s)
  Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N
- Journal Title
  
  Biochemical Journal
  
  Volume: 473 Issue: 1 Pages: 21-30
- DOI
  10.1042/bj20150607
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14481, KAKENHI-PROJECT-26670148, KAKENHI-PUBLICLY-26110723, KAKENHI-PUBLICLY-26117522, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-25430122, KAKENHI-PROJECT-26290019
[Journal Article] Cognitive deficits in single App knock-in mouse models2016
- Author(s)
  A. Masuda, Y. Kobayashi, N. Kogo, T. Saito, T.C. Saido and S. Itohara
- Journal Title
  
  Neurobiology of Learning and Memory
  
  Volume: 135 Pages: 73-82
- DOI
  10.1016/j.nlm.2016.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] ScaleS: an optical clearing palette for biological imaging.2016
- Author(s)
  Hama H, Hioki H, Namiki K, Hoshida T, Kurokawa H, Ishidate F, Kaneko T, Akagi T, Saito T, Saido T, *Miyawaki A.
- Journal Title
  
  Nature Neuroscience
  
  Volume: 18 Issue: 10 Pages: 1518-1529
- DOI
  10.1038/nn.4107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14333, KAKENHI-PUBLICLY-15H01430, KAKENHI-PROJECT-26290019
[Journal Article] Calpain activation in Alzheimer’s model mice is an artifact of APP and presenilin overexpression.2016
- Author(s)
  T. Saito, Y. Matsuba, N. Yamazaki, S. Hashimoto and T.C. Saido
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 36 Issue: 38 Pages: 9933-9936
- DOI
  10.1523/jneurosci.1907-16.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.2015
- Author(s)
  Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC
- Journal Title
  
  American Journal of Pathology
  
  Volume: 185 Issue: 2 Pages: 305-313
- DOI
  10.1016/j.ajpath.2014.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290019, KAKENHI-PROJECT-26670811, KAKENHI-PROJECT-26221310
[Journal Article] Neuronal store-operated calcium entry and mushroom spine loss in APP knock-in mouse model of Alzheimer’s disease.2015
- Author(s)
  H. Zhang, L. Wu, E. Pchitskaya, O. Zaharova, T. Saito, T.C. Saido and I. Bezprozanny
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 35 Issue: 39 Pages: 13275-13286
- DOI
  10.1523/jneurosci.1034-15.2015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] GPR3 modulation of the amyloid plaque burden and memory in Alzheimer’s disease.2015
- Author(s)
  Y. Huang, A. Skwarek-Maruszewska, K Horré, E Vandewyer, L. Wolfs, A. Snellinx, T. Saito, E. Radaelli, N. Corthout, A. C. Lo, L. Van Aerschot, Z. Callaerts-Vegh, D. Trabzuni, K. Bossers, J. Verhaagen, M. Ryten, S. Munck, R. D’Hooge, D.F. Swaab, J. Hardy, T.C. Saido, B. De Strooper and A. Thathiah
- Journal Title
  
  Science Translational Medicine
  
  Volume: 7 Issue: 309
- DOI
  10.1126/scitranslmed.aab3492
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] Single APP knockin mouse models of Alzheimer's disease2014
- Author(s)
  T. Saito, Y. Matsuba, N. Mihira, J. Takano, P. Nilsson, S. Itohara, N. Iwata, T.C. Saido
- Journal Title
  
  Nature Neuroscience
  
  Volume: 17 Issue: 5 Pages: 661-663
- DOI
  10.1038/nn.3697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680039, KAKENHI-PROJECT-26290019
[Journal Article] New mouse model of Alzheimer's2014
- Author(s)
  Per Nilsson, Takashi Saito, Takaomi C. Saido
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 16 Issue: 7 Pages: 499-502
- DOI
  10.1021/cn500105p
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290019
[Journal Article] Substrate ectodomain is critical for substrate preference and inhibition ofβ-secretase2013
- Author(s)
  S. Funamoto, T. Sasaki, S. Ishihara, M. Nobuhara, M. Nakano, M. Takahashi, T. Saito, N. Kakuda, T. Miyasaka, K. Nishikawa, T.C. Saido, Y. Ihara
- Journal Title
  
  Nature Communications
  
  Volume: 4 Issue: 1 Pages: 1-12
- DOI
  10.1038/ncomms3529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680039
[Journal Article] Human prefoldin inhibits Aβfibrillation and contributes to formation of non-toxic Aβaggregates2013
- Author(s)
  K.M. Sörgjerd, T. Zako, M. Sakono, P.C. Stirling, M.R. Leroux, T. Saito, P. Nilsson, M. Sekimoto, T.C.Saido, M. Maeda
- Journal Title
  
  Biochemistry
  
  Volume: 52 Issue: 20 Pages: 3532-3542
- DOI
  10.1021/bi301705c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680039, KAKENHI-PROJECT-23760758, KAKENHI-PROJECT-24570143
[Journal Article] Αβ secretion and plaque formation depend on autophagy2013
- Author(s)
  Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., Saido, T. C.
- Journal Title
  
  Cell Reports
  
  Volume: 5 Issue: 1 Pages: 61-69
- DOI
  10.1016/j.celrep.2013.08.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01512, KAKENHI-PROJECT-23680039
[Journal Article] Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.2012
- Author(s)
  Kakiya, Naomasa
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 287 Issue: 35 Pages: 29362-29572
- DOI
  10.1074/jbc.m112.340372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500329, KAKENHI-PROJECT-23680039
[Journal Article] Potent amyloidogenicity and pathogenicity of Aβ432011
- Author(s)
  Takashi Saito, Takahiro Suemoto, Nathalie Brouwers, Kristel Sleegers, Satoru Funamoto, Naomi Mihira, Yukio Matsuba, Kazuyuki Yamada, Per Nilsson, Jiro Takano, Masaki Nishimura, Nobuhisa Iwata, Christine Van Broeckhoven, Yasuo Ihara, Takaomi C Saido
- Journal Title
  
  Nature Neuroscience
  
  Volume: 14 Issue: 8 Pages: 1023-1032
- DOI
  10.1038/nn.2858
- NAID
  120006985066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23680039
[Journal Article] Potent amyloidogenicity and pathogenicity of Ass432011
- Author(s)
  Takashi Saito, Takahiro Suemoto, Nathalie Brouwers, Kristel Sleegers, Satoru Funamoto, Naomi Mihira, Yukio Matsuba, Kazuyuki Yamada, Per Nilsson, Jiro Takano, Masaki Nishimura, Nobuhisa Iwata, Christine V. Broeckhoven, Yasuo Ihara, Takaomi C. Saido
- Journal Title
  
  Nature Neuroscience 14
  
  Pages: 1023-1032
- Data Source
  KAKENHI-PROJECT-23650185
[Journal Article] Potent amyloidgenecity and pathogenicity of Aβ432011
- Author(s)
  Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC
- Journal Title
  
  Nature Neuroscience
  
  Volume: 14 Pages: 1023-1032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650185
[Journal Article] Aβ分解酵素ネプリライシンによるアルツハイマー病の予防・治療戦略2010
- Author(s)
  斉藤貴志
- Journal Title
  
  脳21 13
  
  Pages: 53-58
- Data Source
  KAKENHI-PROJECT-21659028
[Journal Article] Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting in Aβ production.2008
- Author(s)
  Y. Tachida, K. Nakagawa, T. Saito, T. Saido, T. Honda, Y. Sato, S. Murayama, T. Endo, G. Sakaguchi, A. Kato, S. Kitazume, Y. Hashimoto
- Journal Title
  
  Journal of Neurochemistry 104
  
  Pages: 1387-1393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19689009
[Journal Article] Somatostatin regulates brain amyloid β peptide, Aβ42, via modulation of proteolytic degradation2005
- Author(s)
  Saito T, Iwata T, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC
- Journal Title
  
  Nature Medicine (in press)
- Data Source
  KAKENHI-PROJECT-15790170
[Journal Article] Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation2005
- Author(s)
  T.Saito, N.Iwata, S.Tsubuki, Y.Takaki, J.Takano, S-M Huang, T.Suemoto, M.Higuch, T.C.Saido
- Journal Title
  
  Nature Medicine 11
  
  Pages: 434-439
- Data Source
  KAKENHI-PROJECT-17790219
[Patent] Somatostatin Receptor2020
- Inventor(s)
  斉藤貴志、西道隆臣、松葉翔子、他５名
- Industrial Property Rights Holder
  斉藤貴志、西道隆臣、松葉翔子、他５名
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03564
[Patent] アルツハイマー病モデル動物およびその用途2006
- Inventor(s)
  西道隆臣、斉藤貴志、岩田修永、高野二郎、末元隆寛
- Industrial Property Rights Holder
  西道隆臣、斉藤貴志、岩田修永、高野二郎、末元隆寛
- Filing Date
  2006-06-20
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] Role of glial response underlying pathogenesis of Alzheimer’s disease2022
- Author(s)
  斉藤貴志
- Organizer
  The 1st Fujita International Symposium on Brain Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03564
[Presentation] Role of microglial inflammatory platforms in AD pathogenesis2022
- Author(s)
  斉藤貴志
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03564
[Presentation] グリア応答/神経炎症とアルツハイマー病2021
- Author(s)
  斉藤貴志
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03564
[Presentation] アルツハイマー病モデルマウスの開発とその問題点、そして今後の展開2021
- Author(s)
  斉藤貴志
- Organizer
  第55回日本実験動物技術者協会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03564
[Presentation] 次世代型アルツハイマー病モデルマウスの開発2016
- Author(s)
  斉藤貴志
- Organizer
  第31回日本薬物動態学会年会
- Place of Presentation
  松本キッセイ文化ホール
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] Biology of Time: Humanization of entire murine tau gene for a better model of AD2016
- Author(s)
  Takashi Saito and Takaomi C. Saido
- Organizer
  Society for Neuroscience
- Place of Presentation
  SanDiego Convention Center
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] アルツハイマー病研究に資するモデルマウスの開発と応用2016
- Author(s)
  斉藤貴志
- Organizer
  日本認知症学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] Somatostatin receptors regulate brain Aβ levels via the modulation of neprilysin activity2016
- Author(s)
  Takashi Saito (Organizer), Per Nilsson, Naomasa Kakiya and Takaomi C. Saido
- Organizer
  The 39th Annual meeting of the Japan Neuroscience Society
- Place of Presentation
  横浜国際会議場
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] アミロイドをターゲットとした認知症予防の試み2016
- Author(s)
  斉藤貴志
- Organizer
  第6回日本認知症予防学会学術集会
- Place of Presentation
  東北大学百周年記念会館
- Year and Date
  2016-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] アルツハイマー病研究に資するモデルマウスの開発と応用2015
- Author(s)
  斉藤貴志、西道隆臣
- Organizer
  日本認知症学会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-04
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] アミロイド病理形成におけるネプリライシンおよびインスリン分解酵素の新知見2015
- Author(s)
  佐藤亘、斉藤貴志、西道隆臣
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] アルツハイマー病における神経炎症制御2015
- Author(s)
  斉藤貴志
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] APPノックインマウスにおけるリン酸化タウ病態の解析2015
- Author(s)
  塚越かおり, 藤岡亮, 細木恵美, 高野二郎, 斉藤貴志, 高島明彦, 西道隆臣
- Organizer
  日本認知症学会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] 次世代型アルツハイマー病モデルマウス脳におけるグルタチオン量減少メカニズムの解析2015
- Author(s)
  橋本翔子、斉藤貴志、西道隆臣
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] 新規アルツハイマー病モデルマウスの作製と応用2014
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、西道隆臣
- Organizer
  日本薬学会
- Place of Presentation
  (熊本)(シンポジウム講演)
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] アルツハイマー病の治療・予防・診断法の確立を目指して2013
- Author(s)
  斉藤貴志
- Organizer
  日本生化学会関東支部例会
- Place of Presentation
  (甲府、山梨県)
- Year and Date
  2013-06-15
- Invited
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Identification of intracellular signal pathway of somatostatin-induced neprilysin activity2013
- Author(s)
  N. Kakiya, T. Saito, P. Nilsson, L. Auboyer, M. Madison and T.C. Saido
- Organizer
  Society for Neuroscience 2013
- Place of Presentation
  (SanDiego, USA) .(ポスター発表)
- Year and Date
  2013-11-12
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Update of novel type and more relevant model mouse for Alzheimer's disease2013
- Author(s)
  T. Saito, Y. Matsuba, N. Mihira, N. Iwata, J. Takano, P. Nilsson and T.C. Saido
- Organizer
  Alzheimer Association of International Conference2013
- Place of Presentation
  (Boston, USA) (口頭発表)
- Year and Date
  2013-07-15
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] The role of intracellular domain in neprilysin for the metabolic pathway and enzymatic activity of nepriylsin2012
- Author(s)
  垣矢直雅、斉藤貴志、Per Nilsson、松葉由紀夫、津吹聡、西道隆臣
- Organizer
  日本生化学会
- Place of Presentation
  (福岡)(ポスター発表)
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Novel type and more relevant model mouse for Alzheimer's disease2012
- Author(s)
  Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson and Takaomi C. Saido
- Organizer
  Annual meeting of Society for Neuroscience 2012(ポスター発表)
- Place of Presentation
  ニューオリンズ(アメリカ)
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] APP knock-in mouse : a novel type and more relevant model mouse for Alzheimer's disease2012
- Author(s)
  T. Saito, Y. Matsuba, N. Mihira, N. Iwata, J. Takano, P. Nilsson and T.C. Saido
- Organizer
  Alzheimer Association of International Conference2012
- Place of Presentation
  (Vancouver, Canada) (ポスター発表)
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] アミロイドβ43によるアルツハイマー病の病態発症・促進機構に関する研究2012
- Author(s)
  斉藤貴志
- Organizer
  日本生化学会
- Place of Presentation
  (福岡)(日本生化学会奨励賞受賞講演)
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] アミロイドss43によるアルツハイマー病の病態発症・促進機構に関する研究2012
- Author(s)
  斉藤貴志
- Organizer
  日本生化学会(日本生化学会奨励賞受賞講演)
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] Novel type and more relevant model mouse for Alzheimer's disease2012
- Author(s)
  T. Saito, Y. Matsuba, N. Mihira, N. Iwata, J. Takano, P. Nilsson and T.C. Saido
- Organizer
  Society for Nueroscience 2012
- Place of Presentation
  (New Orleans, USA) (ポスター発表)
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] The role of intracellular domain in neprilysin for the metabolic pathway and enzymatic activity of neprilysin2012
- Author(s)
  垣矢直雅、斉藤貴志、Per Nilsson、松葉由紀夫、津吹聡、西道隆臣
- Organizer
  日本生化学会(ポスター発表)
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] 新規APPノックインマウスの作製と応用2012
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、岩田修永、高野二郎、Per Nilsson、西道隆臣
- Organizer
  日本認知症学会学術集会(口頭・ポスター発表)
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] 新規APPノックインマウスの作製と応用2012
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、岩田修永、高野二郎、Per Nilsson、西道隆臣
- Organizer
  日本認知症学会
- Place of Presentation
  (つくば、茨城県)(口頭発表)
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] APP knock-in mouse: a novel and more relevant model mouse for Alzheimer's disease2012
- Author(s)
  Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson and Takaomi C. Saido
- Organizer
  Alzheimer's Association International Conference 2012(ポスター発表)
- Place of Presentation
  バンクーバー(カナダ)
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] Analysis of the regulatory mechanisms of neprilysin activity2011
- Author(s)
  Naomasa Kakiya, Takashi Saito, Satoshi Tsubuki, Takaomi C. Saido
- Organizer
  日本生化学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] Aβ43 is the potent pahological accelerator for Alzheimer's disease2011
- Author(s)
  T. Saito, N. Mihira, Y. Matsuba and T.C. Saido
- Organizer
  Alzheimer Association of International Conference2011
- Place of Presentation
  (Paris, France) (ポスター発表)
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Analysis of the regulatory mechanisms of neprilysin activity2011
- Author(s)
  垣矢直雅、斉藤貴志、津吹聡、西道隆臣
- Organizer
  日本生化学会(ポスター発表)
- Place of Presentation
  京都国際会議場
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] Aβ43 is the potent pathological accelerator for Alzheimer's disease2011
- Author(s)
  Saito T., et al
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Paris (France)
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Aβ分解酵素ネプリライシン活性制御メカニズムの解析2010
- Author(s)
  垣矢直雅、斉藤貴志, (以下2名)
- Organizer
  日本生化学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21659028
[Presentation] R278I-プレセニリン1変異が持つユニークな機能～胎生致死とAβ43産生に伴うアミロイド病理の促進～2009
- Author(s)
  斉藤貴志, 以下7名
- Organizer
  日本生化学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology2009
- Author(s)
  斉藤貴志, et al
- Organizer
  International conference of Alzheimer's Disease2009
- Place of Presentation
  Wien, Austria
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] R278I-プレセニリン1変異が持つユニークな機能2009
- Author(s)
  斉藤貴志(以下7名)
- Organizer
  第82回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] R278I-プレセニリン1家族性変異による新知見～胎生致死とAβ43産生に伴うアミロイド病理の促進～2009
- Author(s)
  斉藤貴志, 以下7名
- Organizer
  日本認知症学会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] R278I-プレセニリン1家族性変異による新知見2009
- Author(s)
  斉藤貴志(以下7名)
- Organizer
  第28回日本認知症学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology.2009
- Author(s)
  Takashi Saito(以下7名)
- Organizer
  International Conference for Alzheimer's Disease 2009
- Place of Presentation
  Vienna, Austria
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] Accelerated Aβ plaque formation by low level expression of presenilin-1 with R278I mutation in knock-in mouse.2008
- Author(s)
  Takahiro Suemoto, Takashi Saito(以下6名)
- Organizer
  International Conference for Alzheimer's Disease 2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] R278I変異プレセニリン1ノックインマウスにおけるアミロイドプラーク形成の促進2008
- Author(s)
  末元隆寛、斉藤貴志(以下6名)
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-09
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] The 2nd generation mouse mpdel for Alzheimer's Disease.2008
- Author(s)
  Takashi Saito, et al.
- Organizer
  International conference of Alzheimer's Disease2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] The 2nd generation mouse model for Alzheimer's disease.2008
- Author(s)
  Takashi Saito(以下4名)
- Organizer
  International Conference for Alzheimer's Disease 2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] Accelerated Aβplaque formation by low level expression of Presenilin-1 with R278I mutation in knock-in mouse.2008
- Author(s)
  T. Suemoto, and T. Saito , et al.
- Organizer
  International conference of Alzheimer's Disease2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] 次世代型アルツハイマー病モデルマウスの作製及びその解析2007
- Author(s)
  斉藤貴志(以下4名)
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] APP-KI, a novel type mouse, for Alzheimer's disease.2007
- Author(s)
  Takashi Saito(以下4名)
- Organizer
  The 37 th annual meeting of the Society for Neuroscience
- Place of Presentation
  SanDiego, USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] APP-KI mice, a novel type mouse model, for Alzheimer's disease2007
- Author(s)
  Takashi Saito, et. al
- Organizer
  Society for neuroscience
- Place of Presentation
  SanDiego, USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] 次世代型アルツハイマー病モデルの作製及びその解析2007
- Author(s)
  Takashi Saito, et. al
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19689009
[Presentation] Novel type and more relevant model mouse for Alzheimer’s disease
- Author(s)
  Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson and Takaomi C. Saido
- Organizer
  Annual meeting of Society for Neuroscience 2012
- Place of Presentation
  ニューオリンズ（アメリカ）
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Novel type and more relevant model mouse for Alzheimer's disease
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、岩田修永、高野二郎、Per Nilsson、西道隆臣
- Organizer
  Annual meeting of Society for Neuroscience
- Place of Presentation
  ニューオリンズ（アメリカ）
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] 新規アルツハイマー病モデルマウスの作製と応用
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、西道隆臣
- Organizer
  日本薬学会
- Place of Presentation
  熊本県民会館（熊本県）
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Research resource of mouse models for Alzheimer's disease
- Author(s)
  斉藤貴志、西道隆臣
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] The role of intracellular domain in neprilysin for the metabolic pathway and enzymatic activity of neprilysin
- Author(s)
  垣矢直雅、斉藤貴志、Per Nilsson、松葉由紀夫、津吹聡、西道隆臣
- Organizer
  日本生化学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] Generation and application of single APP locus knockin model mice of Alzheimer’s disease
- Author(s)
  Takashi Saito, Yukio Matsuba, Naomi Mihira, Takaomi C. Saido
- Organizer
  Alzheimer Association International Conference 2014
- Place of Presentation
  コペンハーゲン（デンマーク）
- Year and Date
  2014-07-12 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-26290019
[Presentation] The role of intracellular domain in neprilysin for the metabolic pathway and enzymatic activity of neprilysin
- Author(s)
  垣矢直雅、斉藤貴志、Per Nilsson、松葉由紀夫、津吹聡、西道隆臣
- Organizer
  日本生化学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Update of novel type and more relevant model mouse for Alzheimer’s disease
- Author(s)
  Saito T, Matsuba Y, Mihira N, Iwata N, Takano J, Nilsson P and Saido TC
- Organizer
  Alzheimer Association of International Conference2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] APP knock-in mouse: a novel and more relevant model mouse for Alzheimer’s disease
- Author(s)
  Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson and Takaomi C. Saido
- Organizer
  Alzheimer’s Association International Conference 2012
- Place of Presentation
  バンクーバー（カナダ）
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] APP knock-in mouse: a novel and more relevant model mouse for Alzheimer's disease
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、岩田修永、高野二郎、Per Nilsson、西道隆臣
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  バンクーバー（カナダ）
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] 新規APPノックインマウスの作製と応用
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、岩田修永、高野二郎、Per Nilsson、西道隆臣
- Organizer
  日本認知症学会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23650185
[Presentation] アルツハイマー病の治療・予防・診断法の確立を目指して
- Author(s)
  斉藤貴志
- Organizer
  日本生化学会関東支部例会
- Place of Presentation
  山梨大学（山梨県）
- Invited
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] 新規APPノックインマウスの作製と応用
- Author(s)
  斉藤貴志、松葉由紀夫、三平尚美、岩田修永、高野二郎、Per Nilsson、西道隆臣
- Organizer
  日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] アミロイドβ43によるアルツハイマー病の病態発症・促進機構に関する研究
- Author(s)
  斉藤貴志
- Organizer
  日本生化学会
- Place of Presentation
  福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] Identification of intracellular signal pathway of somatostatin-induced neprilysin activity
- Author(s)
  Kakiya N., Saito T., Nilsson P., Auboyer L., Madison M. and Saido T.C.
- Organizer
  Society for Neuroscience
- Place of Presentation
  SanDiego, USA
- Data Source
  KAKENHI-PROJECT-23680039
[Presentation] アミロイドβ43によるアルツハイマー病の病態発症・促進機構に関する研究
- Author(s)
  斉藤貴志
- Organizer
  日本生化学会
- Place of Presentation
  福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23650185

1. TACHIKAWA Masanori (00401810)

# of Collaborated Projects: 1 results

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2. Hidetoshi Arima (50260964)

# of Collaborated Projects: 1 results

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3. 吉良潤一 (40183305)

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4. 川上茂 (20322307)

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5. 北岸宏亮 (60448090)

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6. 山吉麻子 (70380532)

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7. 古賀友紹 (30615092)

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8. 甲斐広文 (30194658)

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9. MATSUBA Yukio

# of Collaborated Projects: 1 results

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10. Mihira Naomi

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11. TAKANO Jiro

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12. 岡澤均

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13. 谷口直之

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14. 肱岡雅宣

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15. HUI Kai-WanKelvin

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# of Collaborated Products: 2 results
16. HUI Kaiwan

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 日置寛之

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# of Collaborated Products: 1 results

Saito Takashi 斉藤 貴志

SAITO Takashi 斉藤 貴志

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Understanding and regulation of non-inflammatory glial responses in the pathogenesis of Alzheimer's diseasePrincipal Investigator

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Development of novel therapeutic strategies of chronic inflammatory diseases by using inflammatory memory cell visualizing mouse

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Elucidation of chemokine cross-talk underlying pathogenesis of Alzheimer's diseasePrincipal Investigator

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Development of innovative drugs having multistep action for treatment of central cerebral amyloidosis

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Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system

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Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's diseasePrincipal Investigator

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Establishment of the diagnostics of Alzheimer' s disease using A・43Principal Investigator

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Establishment and application of novel type of Alzheimer's disease model mousePrincipal Investigator

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ネプリライシンを中軸とするアルツハイマー病予防・治療のための創薬標的の探索Principal Investigator

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Generation and application of the novel mouse model for Alzheimer's diseasePrincipal Investigator

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ソマトスタチンによるアミロイドβ分解酵素ネプリライシンの活性制御機構の解明Principal Investigator

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アミロイドβ分解酵素ネプリライシンの発現及び活性制御機構の解明Principal Investigator

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[Book] Chronic Inflammation-Mechanisms and Regulation2016

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Total Pages

Saito Takashi 斉藤貴志

SAITO Takashi 斉藤貴志