Tachikawa Masanori 立川正憲

… Alternative Names

Researcher Number	00401810
Other IDs
Affiliation (Current)	2021: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 2016 – 2019: 東北大学, 薬学研究科, 准教授 2017: 東北大学, 大学院薬学研究科, 准教授 2012 – 2017: 東北大学, 薬学研究科(研究院), 准教授 2015: 東北大学, 大学院薬学研究科, 准教授 … More
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological Sciences / Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Medical pharmacy / Digestive surgery / Food science / Pediatrics / General pharmacology / Neurology … More
Keywords	Principal Investigator トランスポーター / 血液脳関門 / 血液脳脊髄液関門 / 排出輸送 / 輸送 / 定量プロテオミクス / 薬学 / 血液くも膜関門 / 脳脊髄液 / クレアチン … More Except Principal Investigator 血液脳関門 / トランスポーター / 血液脳脊髄液関門 / プロスタグランジン / 定量プロテオミクス / 有機アニオン輸送担体 / 脳・神経 / 脳関門 / リン酸化 / 標的絶対定量プロテオミクス / 輸送担体 / 膵癌 / 抗癌剤 / PGE2 / クレアチントランスポーター / oatp / OAT / 薬学 / 血液クモ膜関門 / 血液脊髄関門 / アストロサイト / グリア細胞 / コネキシン / 多発性硬化症 / アミノ酸トランスポター / LAT1 / プロモーター解析 / 糖尿病網膜症 / 血管新生 / Dual-luciferase assay / クリアランス / 脳脊髄液 / P-糖蛋白 / 可塑性 / 病態 / P-糖タンパク / P-glycoprotein / Pharmacoproteomics / 細胞内情報伝達系 / 脳疾患 / 化学療法 / 抗癌剤耐性 / 質量分析 / 膵臓外科学 / 分子標的薬 / 増殖因子受容体 / 個別化医療 / がん / 個別化 / 脳腫瘍 / 受容体 / 脳内炎症 / プロスタグランジン合成酵素 / リポ多糖 / 神経伝達物質 / タンパク質栄養 / 発達期栄養 / 脳機能 / 精神疾患 / 遺伝子発現 / 発達期低栄養 / タンパク質 / アミノ酸 / 脳神経疾患 / 食品 / 分子栄養学 / 栄養学 / 知的障害 / クレアチン / 先天性代謝異常 / 脳クレアチン欠乏症候群 / 治療薬 / 発達障害 / iPS細胞 / グアニジノ化合物 / クレアチニン / グアニジノ酢酸 / 精神遅滞 / 自閉症 / 血液網膜関門 / マイクロダイアリシス法 / 排出輸送 / estradiol17-βglucuronide / ρ-aminohippuric acid / 免疫染色 / p-aminohiuric acid / estradiol 17-β glucuronide / dehydroepiandrosterone sulfate / Oatp / Blood-retinal barrier / Microdialysis / Efflux transport / Estradiol 17-β glucuronide / p-Aminohippuric acid / 癌 / クレアチン脳欠乏症 / 脳クレアチン欠乏症 / 生体機能利用 / SWATH法 / プロテオミクス / タンパク質絶対発現量 / 局在解析 / ヒト / 種差 / 標的定量プロテオミクス / 網羅的半定量プロテオミクス / 網羅的プロテオミクス / 標的プロテオミクス / 血液くも膜関門 / blood-brain barrier / brain barrier / proteomics / transporter / protein quantification / カルシウムシグナル / カルシウムイメージング / 神経保護因子 / 脳損傷 / 反応性アストロサイト / 薬理学 / 神経細胞死 / 神経内分泌腫瘍 / 肝転移 / CNPY2 / 膵神経内分泌腫瘍 / 膵臓 / 転移 / 網膜色素上皮細胞 / 外側血液網膜関門 / ヘミチャネル / Cx43 / Claudin-11 / 密着結合 / 中枢関門 / Claudin11 / グリア / 発生・分化・老化 / 精神・神経疾患の病態と治療 / 気液界面プラズマ / 短寿命活性種 / 細胞応答 / 高速液流 / マイクロ流路 / マイクロ・ナノデバイス / 細胞・組織 / 生物・生体工学 / 流体工学 / ナノバイオ / 微小血管網 / 虚血再灌流障害 / 多系統萎縮症 / α-シヌクレイン / グリオパチー / グリア標的治療 / 小脳型多系統萎縮症 / 進行型多発性硬化症 / シヌクレイン / オリゴデンドロサイト / ミクログリア Less

ヒトウイルス受容体を介した血液脳関門突破機構に基づくエクソソームの脳細胞標的化Principal InvestigatorOngoing
- Principal Investigator
  
  立川正憲
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokushima
Investigation of the mechanism and prevention for ischemia-reperfusion injury by using blood-brain barrier-on-a-chipOngoing
- Principal Investigator
  
  船本健一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tohoku University
A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expressionOngoing
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
「血液くも膜関門排出輸送に基づく中枢解毒」仮説の実証研究Principal InvestigatorOngoing
- Principal Investigator
  
  立川正憲
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokushima
新概念高速液流気液界面プラズマによる短寿命活性種バイオサイエンスの基盤確立Ongoing
- Principal Investigator
  
  金子俊郎
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 14:Plasma science and related fields
- Research Institution
  Tohoku University
Study of human brain barrier transport mechanism based global and targeted proteomics
- Principal Investigator
  
  Terasaki Tetsuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Functional coupling of the blood-brain barrier and astrocytes in epilepsyPrincipal Investigator
- Principal Investigator
  
  立川正憲
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Transport systems at the arachnoid barrier cells-forming blood-cerebrospinal fluid barrier.Principal Investigator
- Principal Investigator
  
  TACHIKAWA Masanori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokushima
  Tohoku University
Development of order-made therapy for pancreatic cancer controlling of crosstalk between cancer cell and cancer associated fibroblast
- Principal Investigator
  
  Motoi Fuyuhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Amino acid transporter-based drug development for cerebral creatine deficiency syndrome
- Principal Investigator
  
  Terasaki Tetsuya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Investigation of contribution of novel tight junction molecule at the two big central nervous system barriers and its usefulness as a therapeutic target for multiple sclerosis
- Principal Investigator
  
  Uchida Yasuo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Screening and analysis of glial factors for neuroprotection
- Principal Investigator
  
  Kanemaru Kazunori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanism in liver metastasis of gastroenteropancreatic neuroendocrine tumors
- Principal Investigator
  
  Mizuma Masamichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange
- Principal Investigator
  
  IKENAKA Kazuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
Early protein restriction impacts gene/protein expression and function in mature brain
- Principal Investigator
  
  FURUYA Shigeki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyushu University
Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes
- Principal Investigator
  
  WADA Takahito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Retrieval of blood-brain barrier transport function towards dementia preventionPrincipal Investigator
- Principal Investigator
  
  Tachikawa Masanori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Clarification of molecular mechanisms of the blood-brain barrier plasticity based on quantitative targeted absolute proteomics
- Principal Investigator
  
  Terasaki Tetsuya
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Development of order-made therapy for pancreatic cancer based on quantitative proteomics and metabolomics archive
- Principal Investigator
  
  MOTOI Fuyuhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy
- Principal Investigator
  
  TERASAKI TETSUYA
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Pathophysiological role of the blood-brain barrier hemichannels and molecular-targeted diagnosis and therapyPrincipal Investigator
- Principal Investigator
  
  TACHIKAWA MASANORI
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
  University of Toyama
Molecular identification and physiological role of brain-type prostaglandin transporter
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
アミノ酸トランスポーター遺伝子の転写活性調節による網膜血管新生阻害法の開発
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
脳関門輸送系による痙攣誘発性物質の中枢障害回避機構Principal Investigator
- Principal Investigator
  
  立川正憲
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Physiological role of retina-to-blood efflux transport at the inner blood-retinal barrier
- Principal Investigator
  
  HOSOYA Kenichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama

[Book] Plasma Medical Science, pp.175-1902018
- Author(s)
  T. Kaneko, S. Sasaki, K. Takashima, M. Kanzaki, M. Tachikawa, H. Kanetaka, T. Sato, M.G. Kong
- Total Pages
  458
- Publisher
  Elsevier
- ISBN
  9780128150047
- Data Source
  KAKENHI-PROJECT-18H03687
[Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014
- Author(s)
  Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
- Total Pages
  731
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25670067
[Book] Recent progress in the blood-brain barrier and the blood-CSF barrier transport research : Pharmaceutical relevance of drug delivery to the brain. Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014
- Author(s)
  Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
- Publisher
  Springer, New York
- Data Source
  KAKENHI-PROJECT-22689005
[Book] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain–Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014
- Author(s)
  Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Publisher
  Springer, New York
- Data Source
  KAKENHI-PROJECT-24659063
[Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014
- Author(s)
  Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
- Total Pages
  731
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24249011
[Book] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014
- Author(s)
  Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Publisher
  Springer, New York
- Data Source
  KAKENHI-PROJECT-22689005
[Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014
- Author(s)
  Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
- Total Pages
  731
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22689005
[Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014
- Author(s)
  Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Total Pages
  731
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22689005
[Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014
- Author(s)
  Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Total Pages
  731
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24249011
[Book] Systemic route for retinal drug delivery : role of the blood-retinal barrier transporters. Drug Product Development for the Back of the Eye, Kompella U. B. and Edelhauser H. F. (Ed), American Association of Pharmaceutical Scientists2011
- Author(s)
  Tachikawa M, Ganapathy V, Hosoya K
- Publisher
  Press-Springer, New York
- Data Source
  KAKENHI-PROJECT-22689005
[Book] Systemic route for retinal drug delivery : role of the blood-retinal barrier, In Drug Product Development for the Back of the Eye2011
- Author(s)
  Tachikawa M., Ganapathy V., Hosoya K.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22689005
[Book] Creative and Creatine Kinase in Health and Disease2007
- Author(s)
  Tachikawa M.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18790115
[Journal Article] Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells2020
- Author(s)
  Tachikawa Masanori、Murakami Koji、Akaogi Ryo、Akanuma Shin-ichi、Terasaki Tetsuya、Hosoya Ken-ichi
- Journal Title
  
  Neurochemistry International
  
  Volume: 132
- DOI
  10.1016/j.neuint.2019.104600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03390
[Journal Article] Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood-brain barrier.2020
- Author(s)
  Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: - Pages: 420-436
- DOI
  10.1177/0271678x18822801
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-17H04004
[Journal Article] Distinct Transport Properties of Human Pannexin 1 and Connexin 32 Hemichannels2020
- Author(s)
  Tachikawa M, Akaogi R, Taii A, Akanuma SI, Uchida Y, Terasaki T.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109(3) Pages: 1395-1402
- DOI
  10.1016/j.xphs.2019.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-19H03390
[Journal Article] Abundant Expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1, and xCT Transporters in Blood-Arachnoid Barrier of Pig and Polarized Localizations at CSF- and Blood-Facing Plasma Membranes2020
- Author(s)
  Uchida Y, Goto R, Takeuchi H, Luczak M, Usui T, Tachikawa M, Terasaki T.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 48(2) Pages: 135-145
- DOI
  10.1124/dmd.119.089516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22590, KAKENHI-PROJECT-19K16438, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
[Journal Article] Targeted Proteomics-Based Quantitative Protein Atlas of Pannexin and Connexin Subtypes in Mouse and Human Tissues and Cancer Cell Lines2020
- Author(s)
  Tachikawa M, Kaneko Y, Ohtsuki S, Uchida Y, Watanabe M, Ohtsuka H, Terasaki T.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109(2) Pages: 1161-1168
- DOI
  10.1016/j.xphs.2019.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-19H03390
[Journal Article] Identification of Blood-Brain Barrier-Permeable Proteins Derived from a Peripheral Organ: In Vivo and in Vitro Evidence of Blood-to-Brain Transport of Creatine Kinase.2019
- Author(s)
  Sato K, Tachikawa M, Watanabe M, Miyauchi E, Uchida Y, Terasaki T
- Journal Title
  
  Mol Pharm.
  
  Volume: - Pages: 247-257
- DOI
  10.1021/acs.molpharmaceut.8b00975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16J02046, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004
[Journal Article] Selective Protein Expression Changes of Leukocyte-Migration-Associated Cluster of Differentiation Antigens at the Blood–Brain Barrier in a Lipopolysaccharide-Induced Systemic Inflammation Mouse Model without Alteration of Transporters, Receptors or Tight Junction-Related Protein2019
- Author(s)
  Sato K, Tachikawa M, Watanabe M, Uchida Y, Terasaki T.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42(6) Issue: 6 Pages: 944-953
- DOI
  10.1248/bpb.b18-00939
- NAID
  130007657682
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
[Journal Article] Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood-brain barrier transporters.2019
- Author(s)
  Hoshi Yutaro、Uchida Yasuo、Kuroda Takashi、Tachikawa Masanori、Couraud Pierre-Olivier、Suzuki Takashi、Terasaki Tetsuya
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: -
- DOI
  10.1177/0271678x19868880
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
[Journal Article] Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis.2019
- Author(s)
  Uchida Y, Sumiya T, Tachikawa M, Yamakawa T, Murata S, Yagi Y, Sato K, Stephan A, Ito K, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T.
- Journal Title
  
  Mol Neurobiol.
  
  Volume: 56 Pages: 2039-2056
- DOI
  10.1007/s12035-018-1207-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218, KAKENHI-PUBLICLY-18H04534
[Journal Article] Organic Anion Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats2019
- Author(s)
  Yaguchi Y, Tachikawa M, Zhang Z, Terasaki T.
- Journal Title
  
  Mol Pharm
  
  Volume: 16(5) Pages: 2021-2027
- DOI
  10.1021/acs.molpharmaceut.9b00005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08364
[Journal Article] Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters2019
- Author(s)
  Hellinen L, Sato K, Reinisalo M, Kidron H, Rilla K, Tachikawa M, Uchida Y, Terasaki T, Urtti A.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 60(15) Pages: 5022-5034
- DOI
  10.1167/iovs.19-27328
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22590, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
[Journal Article] Cluster of Differentiation 46 Is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28).2019
- Author(s)
  Kuroda H, Tachikawa M, Yagi Y, Umetsu M, Nurdin A, Miyauchi E, Watanabe M, Uchida Y, Terasaki T
- Journal Title
  
  Mol Pharm.
  
  Volume: - Pages: 292-304
- DOI
  10.1021/acs.molpharmaceut.8b00985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16J02928, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004
[Journal Article] Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells2019
- Author(s)
  Ochiai Y, Uchida Y, Tachikawa M, Couraud PO, Terasaki T.
- Journal Title
  
  J Neurochem.
  
  Volume: 150(4) Pages: 385-401
- DOI
  10.1111/jnc.14722
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22590, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
[Journal Article] Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels.2018
- Author(s)
  Tachikawa M, Toki H, Watanabe M, Tomi M, Hosoya K, Terasaki T.
- Journal Title
  
  Anatomical Science International
  
  Volume: - Pages: 456-463
- DOI
  10.1007/s12565-018-0435-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08364, KAKENHI-PUBLICLY-16H01326, KAKENHI-WRAPUP-18H05199
[Journal Article] Cell-type-specific spatiotemporal expression of creatine biosynthetic enzyme S-adenosylmethionine: guanidinoacetate N-methyltransferase in developing mouse brain2018
- Author(s)
  Tachikawa M, Watanabe M, Fukaya M, Sakai K, Terasaki T, Hosoya K.
- Journal Title
  
  Neurochem Res
  
  Volume: 43 Pages: 500-510
- DOI
  10.1007/s11064-017-2446-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15153
[Journal Article] Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins.2018
- Author(s)
  Akanuma S., Higashi H., Maruyama S., Murakami K., Tachikawa M., Kubo Y., Hosoya K.
- Journal Title
  
  Exp. Eye Res.
  
  Volume: 168 Pages: 128-37
- DOI
  10.1016/j.exer.2018.01.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08365, KAKENHI-PROJECT-16H05110, KAKENHI-PROJECT-16K15157
[Journal Article] Assembly of Taurine Transporter (Slc6a6) with Na+–H+ Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity2018
- Author(s)
 Tachikawa M, Yokoyama R, Akanuma SI, Hosoya K.
- Journal Title
 
 Biol. Pharm. Bull.
 
 Volume: 41(3) Issue: 3 Pages: 338-341
- DOI
 10.1248/bpb.b17-00664
- NAID
 130006407354
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PUBLICLY-16H01326
[Journal Article] Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.2018
- Author(s)
  Tachikawa Masanori、Yashiki Ayane、Akanuma Shin-ichi、Matsukawa Haruka、Ide Soichiro、Minami Masabumi、Hosoya Ken-ichi
- Journal Title
  
  Neurochem Int
  
  Volume: 113 Pages: 1-7
- DOI
  10.1016/j.neuint.2017.11.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08612, KAKENHI-PROJECT-16K15153
[Journal Article] Drug clearance from cerebrospinal fluid mediated by organic anion transporters 1 (Slc22a6) and 3 (Slc22a8) at arachnoid membrane of rats2018
- Author(s)
  Zhang Z, Tachikawa M, Uchida Y, Terasaki T.
- Journal Title
  
  Mol Pharm
  
  Volume: 15(3) Pages: 911-922
- DOI
  10.1021/acs.molpharmaceut.7b00852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08364, KAKENHI-PROJECT-16H06218
[Journal Article] Inner blood-retinal barrier dominantly expresses breast cancer resistance protein: Comparative quantitative targeted absolute proteomics (QTAP) study of CNS barriers in pig2017
- Author(s)
  Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S, Hosoya K, Urtti A, Terasaki T, Tachikawa M
- Journal Title
  
  Mol Pharm
  
  Volume: 14 Pages: 3729-3738
- DOI
  10.1021/acs.molpharmaceut.7b00493
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16K15475
[Journal Article] Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization2017
- Author(s)
 T. Uemura, S. Ito, Y. Ohta, M. Tachikawa, T. Wada, T. Terasaki, S. Ohtsuki
- Journal Title
 
 Biol. Pharm. Bull.
 
 Volume: 40 Issue: 1 Pages: 49-55
- DOI
 10.1248/bpb.b16-00582
- NAID
 130005188881
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-26293035, KAKENHI-PROJECT-26461544
[Journal Article] Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells2017
- Author(s)
  Yutaro Hoshi, Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki, Tetsuya Terasaki
- Journal Title
  
  J Neurochem
  
  Volume: 印刷中 Pages: 247-262
- DOI
  10.1111/jnc.13960
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J06383, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16K15475
[Journal Article] 脳脊髄液中物質動態における脳脊髄液と接する関門の役割：脈絡叢上皮細胞、クモ膜上皮細胞、脊髄毛細血管内皮細胞における細胞膜輸送2017
- Author(s)
  張正宇、立川正憲、寺崎哲也
- Journal Title
  
  神経内科Neurological Medicine
  
  Volume: 87 Pages: 253-263
- Data Source
  KAKENHI-PROJECT-17H04004
[Journal Article] Quantitative Targeted Absolute Proteomics of Rat Blood-Cerebrospinal Fluid Barrier Transporters: Comparison with a Human Specimen.2015
- Author(s)
  Uchida Y, Zhang Z, Tachikawa M, Terasaki T.
- Journal Title
  
  J Neurochem
  
  Volume: 134 Pages: 1104-1115
- DOI
  10.1111/jnc.13147
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249011
[Journal Article] Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells.2014
- Author(s)
  Ito S, Ohtsuki S, Murata S, Katsukura Y, Suzuki H, Funaki M, Tachikawa M, Terasaki T
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 38 Pages: 185-200
- DOI
  10.3233/jad-122077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670067
[Journal Article] Quantitative targeted proteomics for understanding the blood-brain barrier : towards pharmacoproteomics2014
- Author(s)
  Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T
- Journal Title
  
  Expert Rev Proteomics
  
  Volume: (in press)
- DOI
  10.1586/14789450.2014.893830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.2014
- Author(s)
  Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T
- Journal Title
  
  Expert Rev Proteomics
  
  Volume: 11 Pages: 303-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249011
[Journal Article] Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers.2014
- Author(s)
  Tachikawa M, Hosoya K, Terasaki T
- Journal Title
  
  Adv Pharmacol
  
  Volume: 71 Pages: 337-360
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670067
[Journal Article] Pharmacokinetics of guanidinosuccinic acid in rat blood and cerebrospinal fluid.2014
- Author(s)
  Kasai Y, Akanuma SI, Kubo Y, Tachikawa M, Hosoya K
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 29 Pages: 97-100
- NAID
  130004463342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670067
[Journal Article] A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice.2013
- Author(s)
  Y Uchida, M Tachikawa, W Obuchi, Y Hoshi, Y Tomioka, S Ohtsuki, T Terasaki
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 10 Pages: 21-21
- DOI
  10.1186/2045-8118-10-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011, KAKENHI-PROJECT-25670067
[Journal Article] 血液脳関門トランスポートソームの定量的絶対発現プロファイル : 動物種間, 系統間, 野生型-遺伝子欠損マウス間の相違性と類似性2013
- Author(s)
  内田康雄, 立川正憲, 星裕太朗, 寺崎哲也
- Journal Title
  
  脳21
  
  Volume: 16 Pages: 46-52
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice2013
- Author(s)
  Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 10(1) Pages: 21-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Quantitative Expression of Human Drug Transporter Proteins in Lung Tissues : Analysis of Regional, Gender and Inter-individual differences by Liquid Chromatography-Tandem Mass Spectrometry. E-pub ahead of print2013
- Author(s)
  Sakamoto A, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Journal Title
  
  J Pharm Sci
  
  Volume: 102(9) Pages: 3395-3406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659063
[Journal Article] Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset2013
- Author(s)
  Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3343-3355
- DOI
  10.1002/jps.23575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011, KAKENHI-PROJECT-25670067
[Journal Article] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model2013
- Author(s)
  Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T
- Journal Title
  
  Mol Pharm
  
  Volume: 10 Pages: 289-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry.2013
- Author(s)
  Sakamoto A, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3395-3406
- DOI
  10.1002/jps.23606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011
[Journal Article] A Study Protocol for Quantitative Targeted Absolute Proteomics (QTAP) by LC-MS/MS : Application for Inter-Strain Differences in Protein Expression Levels of Transporters, Receptors, Claudin-5, and Marker Proteins at the Blood-Brain Barrier in ddY, FVB, and C57BL/6J mice2013
- Author(s)
  Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 10(1) Pages: 21-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659063
[Journal Article] 動的インターフェースとしての脳関門輸送システムと脳関門生理学・創薬研究2013
- Author(s)
  立川正憲, 内田康雄, 寺崎哲也
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 65 Pages: 121-137
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.2013
- Author(s)
  Ohtsuki S
- Journal Title
  
  Mol Pharm
  
  Volume: 10 Pages: 289-296
- DOI
  10.1021/mp3004308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011, KAKENHI-PROJECT-25670067
[Journal Article] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset2013
- Author(s)
  Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3343-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] 血液脳関門トランスポートソームの定量的絶対発現プロファイル：動物種間，系統間，野生型-遺伝子欠損マウス間の相違性と類似性2013
- Author(s)
  内田康雄、立川正憲、星裕太朗、寺崎哲也
- Journal Title
  
  脳21
  
  Volume: 16 Pages: 46-52
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] 標的絶対定量プロテオミクスが拓くヒト血液脳関門輸送機能研究2013
- Author(s)
  立川正憲, 内田康雄, 寺崎哲也
- Journal Title
  
  Drug Delivery System
  
  Volume: 28 Pages: 270-278
- NAID
  130003384377
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid : role of the blood-cerebrospinal barrier transporters2012
- Author(s)
  Tachikawa M, Tsuji K, Yokoyama R, Higuchi T, Ozeki G, Yashiki A, Akanuma S, Hayashi K, Nishiura A, Hosoya K
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 343 Pages: 608-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E_2 produced in the brain2012
- Author(s)
  Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K
- Journal Title
  
  J Neurochem
  
  Volume: 12 Pages: 750-760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E_2 produced in the brain2012
- Author(s)
  Tachikawa M
- Journal Title
  
  J. Neurochem.
  
  Volume: 123 Pages: 750-60
- DOI
  10.1111/jnc.12018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-24659072
[Journal Article] A clearance system for prostaglandin D_2, a sleep-promoting factor, in cerebrospinal fluid : role of the blood-cerebrospinal barrier transporters2012
- Author(s)
  Tachikawa M
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 343 Pages: 608-16
- DOI
  10.1124/jpet.112.197012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-24659072
[Journal Article] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier2011
- Author(s)
  Tachikawa M, Murakami K, Martin P, Hosoya K, Ganapathy V
- Journal Title
  
  Microvas Res
  
  Volume: 82 Pages: 385-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins2011
- Author(s)
  Hosoya K, Tachikawa M
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 15 Pages: 478-485
- NAID
  10029571602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] The inner blood-retinal barrier mediates L-isomer-predominant transport of serine2011
- Author(s)
  Tachikawa M., Okamoto M., et al
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Pages: 3892-3903
- DOI
  10.1002/jps.22626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Molecular-weight-dependent, Anionic-substrate-preferential Transport of .BETA.-Lactam Antibiotics via Multidrug Resistance-associated Protein 42011
- Author(s)
  Akanuma S., Uchida Y., Ohtsuki S., Kamiie J., Tachikawa M., Terasaki T., Hosoya K.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 6 Pages: 602-11
- DOI
  10.2133/dmpk.dmpk-11-rg-063
  10.2133/dmpk.DMPK-11-RG-063
- NAID
  130004933500
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150, KAKENHI-PROJECT-23790170
[Journal Article] Transport systems of serine at the brain barriers and in brain parenchymal cells2011
- Author(s)
  Kasai Y., Tachikawa M., Hirose S., Akanuma S., Hosoya K.
- Journal Title
  
  J Neurochem
  
  Volume: 118 Pages: 304-13
- DOI
  10.1111/j.1471-4159.2011.07313.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22689005
[Journal Article] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins2011
- Author(s)
  Hosoya K., Tachikawa M.
- Journal Title
  
  Clin. Exp. Nephrol.
  
  Volume: 15 Pages: 478-85
- DOI
  10.1007/s10157-011-0460-y
- NAID
  10029571602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier2011
- Author(s)
  Tachikawa M., Murakami K., et al
- Journal Title
  
  Microvasc Res
  
  Volume: 82 Pages: 385-390
- DOI
  10.1016/j.mvr.2011.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide- induced inflammation and additive inhibitory effect of cefmetazole2011
- Author(s)
  Akanuma S., Uchida Y., Ohtsuki S., Kamiie J., Tachikawa M., Terasaki T., Hosoya K.
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 8 Pages: 24-24
- DOI
  10.1186/2045-8118-8-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150, KAKENHI-PROJECT-23790170
[Journal Article] 定量的絶対標的プロテオミクスに基づくヒト血液脳関門におけるトランスポーターの発現と生理機能2011
- Author(s)
  立川正憲, 内田康雄, 大槻純男, 寺崎哲也
- Journal Title
  
  脳21
  
  Volume: 14 Pages: 42-48
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.2011
- Author(s)
  Tachikawa M.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Pages: 13-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Hypertonicity Enhances GABA Uptake by Cultured Rat Retinal Capillary Endothelial Cells2011
- Author(s)
  Yahara T, Tachikawa M, Akanuma S, Hosoya K
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 611-615
- NAID
  10027744026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Amyloid-b peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011
- Author(s)
  Fujiyoshi M., Tachikawa M., Ohtsuki S., Ito S., Uchida Y., Akanuma S., Kamiie J., Hashimoto T., Hosoya K., Iwatsubo T., Terasaki T.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 118 Pages: 407-15
- DOI
  10.1111/j.1471-4159.2011.07311.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-23790170
[Journal Article] Strategies for therapy of retinal diseases using systemic drug delivery : relevance of transporters at the blood-retinal barrier2011
- Author(s)
  Hosoya K, Tomi M, Tachikawa M
- Journal Title
  
  Expert Opin Drug Deliv
  
  Volume: 8 Pages: 1571-1587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011
- Author(s)
  Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T
- Journal Title
  
  J Neurochem
  
  Volume: 118 Pages: 407-415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders2011
- Author(s)
  Tachikawa M, Hosoya K
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Pages: 13-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders2011
- Author(s)
  Tachikawa M., Hosoya K.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Pages: 13-13
- DOI
  10.1186/2045-8118-8-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] The Inner Blood-Retinal Barrier Mediates L-Isomer-Predominant Transport of Serine2011
- Author(s)
  Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma S, Terasaki T, Hosoya K
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Pages: 3892-903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.2011
- Author(s)
  Tachikawa M., Hosoya K.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins2010
- Author(s)
  Akanuma S., Hosoya K., Ito S., Tachikawa M., Terasaki T, Ohtsuki S.
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 333 Pages: 912-9
- DOI
  10.1124/jpet.109.165332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150
[Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability2010
- Author(s)
  Hosoya K, Yamamoto A, Akanuma S, Tachikawa M
- Journal Title
  
  Pharm Res
  
  Volume: 27 Pages: 2715-2724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005
[Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability2010
- Author(s)
  Hosoya K., Yamamoto A., Akanuma S., Tachikawa M.
- Journal Title
  
  Pharm. Res
  
  Volume: 27 Pages: 2715-24
- DOI
  10.1007/s11095-010-0272-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells.2008
- Author(s)
  Tachikawa M.
- Journal Title
  
  Microvascular Research 75
  
  Pages: 68-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790115
[Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008
- Author(s)
  M, Tachikawa, H, Toki, M, Tomi, K, Hosoya
- Journal Title
  
  Microvasc. Res 75
  
  Pages: 68-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008
- Author(s)
  M. Tachikawa
- Journal Title
  
  Microvasc. Res. 75
  
  Pages: 68-72
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008
- Author(s)
  M. Tachikawa
- Journal Title
  
  Microvasc. Res 75
  
  Pages: 68-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Na^+-independent choline transport in rat retinal capillary endothelial cells2007
- Author(s)
  M, Tomi, K, Arai, M, Tachikawa, K, Hosoya
- Journal Title
  
  Neurochem. Res 32
  
  Pages: 1833-1842
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of α-tocopherol using cultured rat retinal capillary endothelial cells.2007
- Author(s)
  M. Tachikawa
- Journal Title
  
  Mol. Vis. 13
  
  Pages: 2041-2047
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of α-tocopherol using cultured rat retinal capillary endothelihal cells.2007
- Author(s)
  Tachikawa M.
- Journal Title
  
  Molecular Vision 13
  
  Pages: 2041-2047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790115
[Journal Article] Functional involvement of scavenger receptor class B, type I, in the upt ake of α-tocopherol using cultured rat retinal capillary endothelial cells2007
- Author(s)
  M. Tachikawa
- Journal Title
  
  Mol. Vis 13
  
  Pages: 2041-2047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of a-tocopherol using cultured rat retinal capillary endothelial cells2007
- Author(s)
  M, Tachikawa, S, Okayasu, K, Hosoya
- Journal Title
  
  Mol. Vis 13
  
  Pages: 2041-2047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier2006
- Author(s)
  K, Nagase, M, Tomi, M, Tachikawa, K, Hosoya
- Journal Title
  
  Biochim. Biophys. Acta 1758
  
  Pages: 13-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Distribution of microsomal prostaglandin E synthase-1 in the mouse brain
- Author(s)
  Eskilsson A., Tachikawa M., Hosoya K., Blomqvist A.
- Journal Title
  
  J. Comp. Neurol.
  
  Volume: (印刷中)
- DOI
  10.1002/cne.23593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659072
[Presentation] SWATH定量プロテオミクスに基づくヒト小児てんかんの焦点部位における血液脳関門と脳実質組織の病態変動機構の網羅的解明2020
- Author(s)
  佐藤理沙、内田康雄、大森広太郎、梅津美奈、Gerald Grant、Brenda Porter、Anthony Bet、立川正憲、臼井拓也、寺崎哲也
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 薬剤耐性型てんかん患者の血液脳関門で薬物代謝酵素が発現上昇する。2019
- Author(s)
  佐藤理沙、内田康雄、大森広太郎、梅津美奈、Gerald Grant、Brenda Porter、Anthony Bet、立川正憲、臼井拓也、寺崎哲也
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開2019
- Author(s)
  立川正憲
- Organizer
  第41回神経組織培養研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03390
[Presentation] 中枢関門科学：Connecting the human dots2019
- Author(s)
  立川正憲
- Organizer
  第13回次世代を担う若手医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K22599
[Presentation] Blood-brain barrier-permeable proteins and transport characteristics in brain endothelial cells2019
- Author(s)
  Tachikawa M, Terasaki T
- Organizer
  日本薬物動態学会第34年会
- Data Source
  KAKENHI-PROJECT-19H03390
[Presentation] 膜タンパク質に対する網羅的なタンパク質絶対定量法 “QGAP 法 ” の開発：ヒト血液脳関門における網羅的な絶対発現量アトラス2019
- Author(s)
  平野誠巳, 内田康雄, 梅津美奈, 後藤諒平, 八木悠太, 立川正憲, 田野光敏, 高尾昌樹, 寺崎哲也
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Anti-epileptic drug metabolizing enzymes are upregulated at the blood-brain barrier in pharmacoresistant childhood epilepsy: SWATH-based comprehensive quantitative proteomic study2019
- Author(s)
  R Sato, Y Uchida, K Omori, M Umetsu, G Grant, B Porter, A Bet, M Tachikawa, T Usui, and T Terasaki
- Organizer
  34th JSSX annual conference
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Blood-brain barrier-permeable proteins and transport characteristics in brain endothelial cells2019
- Author(s)
  Tachikawa M, Terasaki T
- Organizer
  日本薬物動態学会第34年会
- Data Source
  KAKENHI-PROJECT-19K22599
[Presentation] (口頭発表部門で優秀発表賞を受賞) 脈絡叢と脳軟髄膜の標的プロテオミクス解析：ブタ1 頭あたりの脈絡叢と脳軟髄膜におけるトランスポータータンパク質の発現量解析と膜タンパク質の膜局在の網羅的解明2019
- Author(s)
  後藤諒平、内田康雄、竹内妃奈、Magdalena Luczak、臼井拓也、立川正憲、寺崎哲也
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 中枢関門科学：Connecting the human dots2019
- Author(s)
  立川正憲
- Organizer
  第13回次世代を担う若手医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03390
[Presentation] The human-specific virus receptor CD46 makes a major contribution to the internalization of brain-metastatic melanoma-derived exosomes by human blood-brain barrier endothelial cells.2019
- Author(s)
  Tachikawa M, Kuroda H, Watanabe M, Uchida Y, Terasaki T
- Organizer
  13th International Conference of Cerebral Vascular Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03390
[Presentation] ヒト血液脳関門における脳転移性メラノーマ由来エクソソームの輸送機構と種差2019
- Author(s)
  立川正憲、寺崎哲也
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] 定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開2019
- Author(s)
  立川正憲
- Organizer
  第41回神経組織培養研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22599
[Presentation] 定量プロテオミクスによるヒト血液脊髄関門における膜タンパク質の定量的発現プロファイルの解明2019
- Author(s)
  八木悠太, 内田康雄, 梅津美奈, 平野誠巳, 立川正憲, 田野光敏, 高尾昌樹, 寺崎哲也
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開2018
- Author(s)
  立川正憲
- Organizer
  第24回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] 多発性硬化症における中枢関門の破綻への新規密着結合分子claudin-11 の寄与の解明2018
- Author(s)
  内田康雄, 住谷智仁, 立川正憲, 山川達也, 村田将, 八木悠太, 佐藤和貴, 伊藤克彰, 大槻純男, Pierre-Olivier Couraud, 鈴木貴, 寺崎哲也
- Organizer
  日本薬剤学会第33 年会
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] Pressure Cycling Technologyを用いたホルマリン固定パラフィン包埋切片プロテオミクス定量系の薬物関連タンパク質への応用2018
- Author(s)
  佐々木颯, 内田康雄, 立川正憲, 寺崎哲也
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] ラット血液脊髄関門と血液脳関門におけるトランスポータータンパク質発現量の類似性と相違性の解明2018
- Author(s)
  八木悠太、内田康雄、立川正憲、寺崎哲也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Sulfo-SBED/SWATHプロテオミクスを用いたヒト血液脳関門モデルhCMEC/D3細胞におけるエクソソーム受容体の同定2018
- Author(s)
  黒田広樹, 立川正憲, 八木悠太, 内田康雄, 寺崎哲也
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 網羅的定量プロテオミクスと薬動力学に基づくプラズマ生体作用の分子的解明2018
- Author(s)
  立川正憲
- Organizer
  第40回日本光医学・光生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] 中枢関門の密着結合形成におけるclaudin-11の寄与と多発性硬化症におけるその発現低下の解明2018
- Author(s)
  住谷智仁、内田康雄、山川達也、村田将、八木悠太、佐藤和貴、伊藤克彰、立川正憲、大槻純男、鈴木貴、寺崎哲也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] ブタ脈絡叢と脳軟髄膜の網羅的・標的プロテオミクス解析：OATP1A2、OCT2及びMATE1の発現局在とCSF中薬物動態における役割2018
- Author(s)
  後藤諒平、内田康雄、立川正憲、平野誠巳、張正宇、寺崎哲也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Usefulness of Pressure Cycling Technology-assisted sample process for accurate and comprehensive quantitative proteomics using FFPE section; application for ADME-related proteins2018
- Author(s)
  Sasaki H, Uchida Y, Tachikawa M, Terasaki T
- Organizer
  第33回日本薬物動態学会・MDO国際合同年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Quantitative targeted and global proteomics analysis of brain microvessels in pharmacoresistant epilepsy2018
- Author(s)
  Omori K, Grant G, Tachikawa M, Porter B, Bet A, Uchida Y, Terasaki T
- Organizer
  2018 Gordon Research Conference on Barriers of the CNS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 血液クモ膜関門を介した脳脊髄液中α-synuclein排出輸送機構の解明2018
- Author(s)
  矢口優佳、立川正憲、内田康雄、寺崎哲也
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 中枢薬剤学-Connecting the dots2018
- Author(s)
  立川正憲
- Organizer
  日本薬剤学会第32年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15153
[Presentation] SWATH及び高精度ペプチド選択を組み合わせた膜タンパク質のApical/Basolateral膜局在と絶対発現量の網羅的推定法の開発2018
- Author(s)
  平野誠巳、内田康雄、立川正憲、後藤諒平、寺崎哲也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 血液クモ膜関門を介した脳脊髄液中α-synuclein排出輸送機構の解明2018
- Author(s)
  矢口優佳、立川正憲、内田康雄、寺崎哲也
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] Sulfo-SBED/SWATH proteomics-based identification of RGD receptor integrins as the receptors for SK-Mel-28-derived exosomes internalization into human blood-brain barrier hCMEC/D3 cells2018
- Author(s)
  Kuroda H, Tachikawa M, Uchida Y, Terasaki T
- Organizer
  2018 Gordon Research Conference on Barriers of the CNS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Identification and absolute quantification of Transporters in the isolated human brain microvessels by next-generation quantitative proteomics SWATH-MS2018
- Author(s)
  Umetsu M, Uchida Y, Hirano S, Takao M, Tachikawa M, Terasaki T
- Organizer
  第33回日本薬物動態学会・MDO国際合同年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Proteomics based characterization of the blood-spinal cord barrier transporters in rats: Comparison with the blood-brain barrier2017
- Author(s)
  八木悠太、立川正憲、内田康雄、寺崎哲也
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] クレアチン脳欠乏症治療を指向したカチオン性アミノ酸トランスポーターを輸送経路とするクレアチンプロドラッグの開発2017
- Author(s)
  太田悠介、立川正憲、吉田将人、土井隆行、和田敬仁、寺崎哲也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16K15153
[Presentation] 脳脊髄液中薬物動態における血液クモ膜関門の役割：　有機アニオン排出経路としてのoatp1a4の輸送機能と発現の証明2017
- Author(s)
  矢口優佳、立川正憲、張正宇、内田康雄、寺崎哲也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] OUTER blood-CSF barrier (arachnoid membrane) abundantly expresses OAT1, OAT3, PEPT2 and BCRP proteins as compared to INNER blood-CSF barrier (choroid plexus)2017
- Author(s)
  後藤諒平、内田康雄、立川正憲、平野誠巳、張正宇、寺崎哲也
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] Development of label free comprehensive absolute quantification method by SWATH-MS combined with in silico peptide selection criteria ~Its application for the hepatic drug delivery~2017
- Author(s)
  平野誠巳、内田康雄、立川正憲、後藤諒平、寺崎哲也
- Organizer
  日本薬物動態学会第32回年会（優秀口頭発表賞受賞）
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] 中枢関門におけるandrogen刺激に応答したclaudin-11発現調節作用の解明と血液クモ膜関門におけるclaudin-11の発現解析2017
- Author(s)
  住谷智仁、内田康雄、山川達也、村田将、張正宇、立川正憲、大槻純男、寺崎哲也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] Development of label free comprehensive absolute quantification method by SWATH-MS combined with in silico peptide selection criteria : Its application for the hepatic drug delivery2017
- Author(s)
  平野誠巳、内田康雄、立川正憲、後藤諒平、寺崎哲也
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 血液脳関門機能の可塑的変化と脳血管-グリア連関2017
- Author(s)
  立川正憲
- Organizer
  千里ライフサイエンスセミナーL3神経変性疾患の最前線(グリア細胞と神経疾患)
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01326
[Presentation] ブタBRB, BBB及びBCSFBの輸送担体の絶対発現量解析：BCRPの重要性2017
- Author(s)
  張正宇、内田康雄、平野誠巳、安藤大介、久保義行、 Seppo Auriola、赤沼伸乙、立川正憲、細谷健一、Arto Urtti、寺崎哲也
- Organizer
  日本薬剤学会第32年会 (最優秀発表賞受賞)
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] 中枢薬剤学-Connecting the dots2017
- Author(s)
  立川正憲
- Organizer
  日本薬剤学会第32年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01326
[Presentation] Oat1/3 and Oatp1a4 are acting as avid elimination pathway of organic anion in the CSF at the blood-arachnoid barrier (BAB)2017
- Author(s)
  Tachikawa M, Yaguchi Y, Zhang Z, Uchida Y, Terasaki T.
- Organizer
  12th INTERNATIONAL CONFERENCE on CEREBRAL VASCULAR BIOLOGY 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] Proteomics based characterization of the blood-spinal cord barrier transporters in rats: Comparison with the blood-brain barrier2017
- Author(s)
  八木悠太、立川正憲、内田康雄、寺崎哲也
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 標的定量質量分析法に基づくクモ膜上皮細胞と脈絡叢上皮細胞の有機アニオントランスポータータンパク質の解析：脳脊髄液中薬物動態における役割評価2017
- Author(s)
  張正宇、立川正憲、内田康雄、寺崎哲也
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] 脳転移性メラノーマ細胞由来exosomesによるヒト脳毛細血管内皮細胞株hCMEC/D3のエネルギー代謝抑制制御2017
- Author(s)
  TRAN Quynh-Phuong、内田康雄、黒田広樹、梅津美奈、八木悠太、立川正憲、寺崎哲也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K15475
[Presentation] 有機アニオン性物質プロスタグランジンD2及びsulforhodamine-101の脳脊髄液クリアランス経路としてのラット血液クモ膜関門Oatp1a4の機能的役割2017
- Author(s)
  矢口優佳、立川正憲、張正宇、内田康雄、寺崎哲也
- Organizer
  第11回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] 標的定量質量分析法に基づくクモ膜上皮細胞と脈絡叢上皮細胞の有機アニオントランスポータータンパク質の解析：脳脊髄液中薬物動態における役割評価2017
- Author(s)
  張正宇、立川正憲、内田康雄、寺崎哲也
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H04004
[Presentation] 脳脊髄液中薬物動態における血液クモ膜関門の役割：有機アニオン排出経路としてのoat1, oat3の輸送機能と発現の証明2017
- Author(s)
  張正宇、立川正憲、内田康雄、矢口優佳、寺崎哲也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター(宮城県仙台市）
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] アラクノイドバリアーにおける有機アニオン輸送体の発現と外側血液脳脊髄液関門としての機能的役割2016
- Author(s)
  立川正憲
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール(長野県松本市)
- Year and Date
  2016-10-14
- Invited
- Data Source
  KAKENHI-PROJECT-16K08364
[Presentation] Abl及びSrc kinasesによる血液脳関門P-glycoproteinの細胞内トラフィッキング制御機構の解明2016
- Author(s)
  星裕太朗、内田康雄、立川正憲、大槻純男、寺崎哲也
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Application of Advanced Quantitative Proteomics to the human blood-brain barrier research.2016
- Author(s)
  Tachikawa M.
- Organizer
  Japanese-German YoungGlia collaborative meeting for mutual research exchange
- Place of Presentation
  Center for Integrative Physiology and Molecular Medicine, University of Saarland (Homburg, Germany)
- Year and Date
  2016-05-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01326
[Presentation] 定量プロテオミクス解析から見えてきた血液脳関門輸送機能の可塑的変化2016
- Author(s)
  立川正憲
- Organizer
  第3回新学術領域研究「グリアアセンブリ」若手の会
- Place of Presentation
  蔵王アストリアホテル(山形県山形市)
- Year and Date
  2016-07-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01326
[Presentation] 発達初期低タンパク質栄養は成熟期の血液脳関門輸送体発現を変化させる2016
- Author(s)
  最上侑佑盛、中畑亜加音、佐藤和貴、立川正憲、古屋茂樹
- Organizer
  日本アミノ酸学会10周年記念大会
- Place of Presentation
  東京大学伊藤国際学術研究センター
- Data Source
  KAKENHI-PROJECT-26292071
[Presentation] グアニジノ化合物の脳内動態と神経疾患2015
- Author(s)
  立川正憲
- Organizer
  第36回部兄時の化合物研究会
- Place of Presentation
  東北大学、仙台
- Year and Date
  2015-08-08
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Pathological impact of hemichannels-mediated gateway on the brain barrier transport dynamics.2015
- Author(s)
  Tachikawa T.
- Organizer
  Pharmaceutical Science Symposium 2015
- Place of Presentation
  Sendai, Japan
- Year and Date
  2015-11-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670067
[Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターの発現・局在と輸送機能特性の解析2015
- Author(s)
  上村立記、伊藤慎悟、太田悠介、立川正憲、平山未央、和田敬仁、寺崎哲也、大槻純男
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 標的プロテオミクスに基づくタンパク質リン酸化修飾の定量的解析2015
- Author(s)
  星裕太朗、内田康雄、立川正憲、大槻純男、寺崎哲也
- Organizer
  日本プロテオーム学会2015年会
- Place of Presentation
  熊本
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Impact of pannexin 1 and connexin 43 hemichannels on extracellular calcium-dependent transport dynamics in human brain capillary endothelial cells.2015
- Author(s)
  Tachikawa M, Kaneko Y, Akaogi R, Uchida Y, Couraud PO, Terasaki T.
- Organizer
  Barcelona BioMed Conference, Blood Brain Barrier
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670067
[Presentation] Post-translational regulation of P-glycoprotein function at the blood-brain barrier involved in caveolin-1 tyrosine 14 phosphorylation.2015
- Author(s)
  Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.
- Organizer
  30th JSSX Annual Meeting
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Molecular genetic study and urine analysis of Japanese patients with cerebral creatine deficiency syndromes.2015
- Author(s)
  H. Shimbo, H. Osaka, M. Tachikawa, S. Ohtsuki, S. Ito, T. Goto, Y. Tsuyusaki, N. Aida, K. Kurosawa, Y. Kurosawa, H. Kato, K. Takano, T. Wada.
- Organizer
  65th American Society of Human Genetics
- Place of Presentation
  Baltimore
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Changes of cellular localization and transport activity by a novel mutation in creatine transporter associated with chronic cerebral creatine depletion2015
- Author(s)
  Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
- Organizer
  International Symposium on Chronic Inflammatory Diseases
- Place of Presentation
  Kumamoto
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Global and Quantitative Targeted Phosphoproteomic Studies on the Blood-Brain Barrier P-gp Regulation Mechanism in Acute Phase Diseased Models.2015
- Author(s)
  Hoshi Y, Uchida Y, Kuroda T, Tachikawa T, Terasaki T
- Organizer
  BioMed Conference, Blood Brain Barrier
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-11-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 血液脳関門ファーマコプロテオミクスに立脚した中枢疾患創薬の提言2015
- Author(s)
  立川正憲、内田康雄、大槻純男、寺崎哲也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] リン酸化定量プロテオミクスに基づく血液脳関門P-glycoproteinの輸送活性制御機構の解明2015
- Author(s)
  星裕太朗、内田康雄、立川正憲、大槻純男、寺崎哲也
- Organizer
  第10回トランスポーター研究会年会
- Place of Presentation
  東京
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 「脳クレアチン欠乏症候群の臨床研究班」の取り組み2015
- Author(s)
  和田敬仁，小坂仁，相田典子，後藤知英，露崎悠，新保裕子，加藤秀一，高野亨子，大槻純男，伊藤慎悟，立川正憲，黒澤裕子
- Organizer
  第57回日本小児神経学会
- Place of Presentation
  大阪
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 新規変異クレアチントランスポーターの機能と発現解析2015
- Author(s)
  上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
- Organizer
  第31回日本薬学会九州支部大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki: Changes in transport activity and cellular localization by a novel missense mutation in human creatine transporter found in Japanese cerebral creatine deficiency syndromes patients2015
- Author(s)
  Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
- Organizer
  Barcelona BioMed Conference Blood Braine Barrier
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 血液脳関門ファーマコプロテオミクスに立脚した中枢疾患創薬の提言2015
- Author(s)
  立川正憲、内田康雄、大槻純男、寺崎哲也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25670067
[Presentation] 前処理自動化と質量分析を組み合わせたハイスループットMRM法の開発2014
- Author(s)
  米山敏広、大槻純男、尾野雅哉、大峰健、内田康雄、立川正憲、寺崎哲也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] 標的定量プロテオミクス解析に基づく病態時血液脳関門輸送系の可塑的変化の解明2014
- Author(s)
  立川正憲、星裕太朗、佐藤和貴、内田康雄、大槻純男、寺崎哲也
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 生体膜薬物輸送研究におけるタンパク質絶対定量情報の活用2014
- Author(s)
  立川正憲
- Organizer
  第22回クリニカルファーマシーシンポジウム医療薬学フォーラム2014
- Place of Presentation
  東京
- Year and Date
  2014-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Plasticity and robustness of the blood-brain-barrier transporters, channels, and receptors: a study of advanced quantitative targeted proteomics.2014
- Author(s)
  Tachikawa M
- Organizer
  19th North American ISSX/29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-25670067
[Presentation] マウス炎症性疾患モデルを用いた脳毛細血管における接着分子の標的定量プロテオミクス解析2014
- Author(s)
  佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
- Organizer
  第22回クリニカルファーマシーシンポジウム医療薬学フォーラム2014
- Place of Presentation
  東京
- Year and Date
  2014-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 標的定量プロテオミクスを活用したクレアチントランスポーター輸送活性評価法の構築2014
- Author(s)
  太田悠介、立川正憲、落合祐介、寺崎哲也
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Plasticity and robustness of the blood-brain-barrier transporters, channels, and receptors: a study of advanced quantitative targeted proteomics.2014
- Author(s)
  Tachikawa M
- Organizer
  19th North American ISSX/29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Pharmacological impact of the brain barrier prostaglandin transport2014
- Author(s)
  Tachikawa M
- Organizer
  20th Annual Blood-Brain Barrier Consortium Meeting
- Place of Presentation
  Sunriver, USA
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 開口スイッチの導入によるpannexin1及びconnexin32機能解析系の構築と輸送特性の解明2014
- Author(s)
  赤荻諒、立川正憲、金子洋介、内田康雄、寺崎哲也
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性2014
- Author(s)
  立川正憲, 金子洋介, 赤荻諒, 内田康雄, 大槻純男, 寺崎哲也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-30
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 標的絶対定量プロテオミクスに基づくがん分子標的化学療法の個別・層別化基盤の構築2014
- Author(s)
  内田康雄、立川正憲、小渕航、大槻純男、中田光俊、濱田潤一郎、寺崎哲也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] 血液脳関門—白血球細胞遊走に関わる接着分子の標的定量プロテオミクス解析2014
- Author(s)
  佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] タンパク質絶対定量情報を活用したクレアチントランスポーター輸送活性予測法の構築2014
- Author(s)
  立川正憲
- Organizer
  第35回グアニジノ化合物研究会
- Place of Presentation
  筑波
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Channels at the Barriers: A Non-Transporter-Mediated Gateway.2014
- Author(s)
  Tachikawa M
- Organizer
  Gordon Research Conference, Barriers of the CNS
- Place of Presentation
  New London, USA
- Year and Date
  2014-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-25670067
[Presentation] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport2013
- Author(s)
  Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto, Canada
- Year and Date
  2013-09-30
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能2013
- Author(s)
  立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 仮想selective reaction monitoring法を用いた白血球細胞膜上タンパク質の高感度標的プロテオミクス2013
- Author(s)
  佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport: An application of quantitative targeted proteomics2013
- Author(s)
  Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
- Organizer
  10th international conference on Cerebral Vascular Biology
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Quantitative targeted absolute proteomics of the malignant brain tumors towards molecular-targeted chemotherapy.2013
- Author(s)
  Terasaki T., Obuchi W., Ohtsuki S.,Nakada M., Uchida Y., Tachikawa M., Hamada J.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] 膜タンパク質を標的とした定量的標的プロテオミクスに基づく悪性脳腫瘍に対する個別化分子標的療法2013
- Author(s)
  小渕航、大槻純男、中田光俊、内田康雄、立川正憲、濱田潤一郎、寺崎哲也
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Year and Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築2013
- Author(s)
  立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 膵癌細胞のゲムシタビン感受性増強を目的とした併用薬のスクリーニング2013
- Author(s)
  黒田広樹、立川正憲、内田康雄、寺崎哲也
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] Quantitative targeted absolute proteomics of the malignant brain tumors towards molecular-targeted chemotherapy2013
- Author(s)
  Terasaki T, Obuchi W, Ohtsuki S, Nakada M, Uchida Y, Tachikawa M, Hamada J
- Organizer
  10th International Society for the Study of Xenobiotics (ISSX) Meeting
- Place of Presentation
  Toronto, Canada
- Year and Date
  2013-09-30
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport.2013
- Author(s)
  Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport : An application of quantitative targeted proteomics2013
- Author(s)
  Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
- Organizer
  10th international conference on Cerebral Vascular Biology
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier2013
- Author(s)
  Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 血液脳関門輸送機能変動因子としてのヘミチャネル2013
- Author(s)
  立川正憲
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-11-22
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research2013
- Author(s)
  Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
- Organizer
  International Gap Junction Conference 2013
- Place of Presentation
  Charleston, USA
- Year and Date
  2013-07-16
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents2012
- Author(s)
  立川正憲, 村上晃路, 赤沼伸乙, 細谷健一
- Organizer
  第2回新潟大学脳研究所共同研究拠点国際シンポジウム
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells2012
- Author(s)
  金子洋介、立川正憲, 他
- Organizer
  BRI International Symposium 2012
- Place of Presentation
  新潟
- Year and Date
  2012-03-03
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Profile of hemichannls mRNA expresson at the blood-brain and inner blood-retinal barriers in mice2012
- Author(s)
  Akanuma S, Murakami K, Tachikawa M, Kubo Y, Hosoya K
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  千葉
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Pathophysiological impact of hemichannels on the blood-brain barrier transport.2012
- Author(s)
  Tachikawa M
- Organizer
  15th International Symposium Signal Transduction in the Blood-Brain Barriers
- Place of Presentation
  Potsdam-Sanssouci, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] ヘミチャネルファミリーを標的とした定量プロテオミクス2012
- Author(s)
  立川正憲, 金子洋介, 内田康雄, 寺崎哲也
- Organizer
  日本薬学会東北支部大会
- Place of Presentation
  青森
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 脳及び網膜毛細血管皮細胞におけるヘミチャネル分子のmRNA発現解析2012
- Author(s)
  村上晃路、立川正憲, 他
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Targeted quantitative LC-MS/MS methods of bevacizumab, a therapeutic monoclonal antibody2012
- Author(s)
  Ebata Y, Ohtsuki S, Tachikawa M, Uchida Y, Terasaki T
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] Proteomics-based technology as a new path to toxicological evaluation2012
- Author(s)
  Tachikawa M
- Organizer
  2012 International Symposium on Green Toxicology & Technology : Prediction of Kidney Toxicity
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] 脳及び網膜毛細血管内皮細胞におけるヘミチャネル分子のmRNA 発現解析2012
- Author(s)
  村上晃路, 立川正憲, 赤沼伸乙, 久保義行, 細谷健一
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells2012
- Author(s)
  金子洋介, 立川正憲, 寺崎哲也
- Organizer
  第2回新潟大学脳研究所共同研究拠点国際シンポジウム
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier2012
- Author(s)
  Tachikawa M, Kaneko Y, Uchida Y, Ohtsuki S, Couraud PO, Terasaki T
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  千葉
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Pathophysiological impact of hemichannels on the blood-brain barrier transport2012
- Author(s)
  Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
- Organizer
  Fifteenth International Symposium Signal Transduction in the Blood-Brain Barriers
- Place of Presentation
  Potsdam-Sanssouci, Germany
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Proteomics-based technology as a new path to toxicological evaluation2012
- Author(s)
  Tachikawa M
- Organizer
  2012 International Symposium on Green Toxicology & Technology : Prediction of Kidney Toxicity
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents2012
- Author(s)
  立川正憲、村上晃路, 他
- Organizer
  BRI International Symposium 2012
- Place of Presentation
  新潟
- Year and Date
  2012-03-03
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 脳脊髄液からのL-glutamate排出輸送解析2011
- Author(s)
  櫻井達彦、赤沼伸乙、立川正憲、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第123回例会
- Place of Presentation
  金沢市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Role of organic anion transporter 3 at the blood-cerebrospinal fluid barrier in the elimination of prostaglandin E_2 produced in the brain2011
- Author(s)
  Akanuma S., Ozeki G., Tachikawa M., Hosoya K.
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島県広島市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] グアニジノ化合物のトランスポーターと脳関門輸送2011
- Author(s)
  立川正憲
- Organizer
  第32回グアニジノ化合物研究会
- Place of Presentation
  酒田(招待講演)
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Role of organic anion transporter 3 at the blood-cerebrospinal fluid barrier in the elimination of prostaglandin E_2 produced in the brain2011
- Author(s)
  Shin-ichi Akanuma, Gou Ozeki, Masanori Tachikawa, Ken-ichi Hosoya
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島市
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] グアニジノ化合物のトランスポーターと脳関門輸送2011
- Author(s)
  立川正憲
- Organizer
  第32回グアニジノ化合物研究会
- Place of Presentation
  酒田
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 脳脊髄液からのL-glutamate排出輸送解析2011
- Author(s)
  櫻井達彦、赤沼伸乙、立川正憲、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第123回例会
- Place of Presentation
  石川県金沢市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割2010
- Author(s)
  立川正憲
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山国際会議場(富山市)
- Year and Date
  2010-11-30
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE2排出の阻害2010
- Author(s)
  赤沼伸乙、伊藤慎悟、立川正憲、大槻純男、細谷健一、寺崎哲也
- Organizer
  日本薬学会第130年会(会期平成22年3月28日-30日)
- Place of Presentation
  岡山桃太郎アリーナ
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE_2排出の阻害2010
- Author(s)
  赤沼伸乙、伊藤慎悟、立川正憲、大槻純男、細谷健一、寺崎哲也
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山県岡山市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割2010
- Author(s)
  立川正憲, 細谷健一
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Year and Date
  2010-11-30
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Effect of lipophilicity and carrier-mediated transport on blood-retinal barrier permeability2010
- Author(s)
  Hosoya K., Yamamoto A., Akanuma S., Tachikawa M.
- Organizer
  FIP pharmaceutical sciences 2010 world congress/AAPS annual meeting and exposition.
- Place of Presentation
  Neu Orileans, USA
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Organic anion transporter3を介したprostaglandin E_2輸送機能解析2010
- Author(s)
  樋口貴則、赤沼伸乙、立川正憲、細谷健一
- Organizer
  日本薬学会北陸支部平成22年度第1回総会及び第122回例会
- Place of Presentation
  石川県金沢市
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 血液脳脊髄液関門を介したprostaglandin E_2排出におけるorganic anion transporter(OAT) 3の関与2010
- Author(s)
  小関剛、赤沼伸乙、立川正憲、細谷健一
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山県富山市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Involvement of Prostaglandin Transporter in Prostaglandin D2 Transport at the Blood-cerebrospinal Fluid Barrier2009
- Author(s)
  Kazuhiro Tsuji, Masanori Tachikawa, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura, Ken-ichi Hosoya
- Organizer
  2009 AAPS Annual Meeting and Exposition
- Place of Presentation
  Los Angeles Convention Center
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析2009
- Author(s)
  小関剛、辻和宏、赤沼伸乙、立川正憲、細谷健一
- Organizer
  日本薬学会北陸支部第121回例会
- Place of Presentation
  富山大学杉谷(医薬系)キャンパス
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析2009
- Author(s)
  小関剛、辻和宏、赤沼伸乙、立川正憲、細谷健一
- Organizer
  日本薬学会北陸支部第121回例会
- Place of Presentation
  富山県富山市
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Localization and transport function of prostaglandin transporter (PGT) in the brain2009
- Author(s)
 Kazuhiro Tsuji, Masanori Tachikawa, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura, Ken-ichi Hosoya
- Organizer
 8^<th> Cerebral Vascular Biology 2009
- Place of Presentation
 仙台エクセルホテル東急
- Data Source
 KAKENHI-PROJECT-21390042
[Presentation] Involvement of Prostaglandin Transporter in Prostaglandin D_2 Transport at the Blood-cerebrospinal Fluid Barrier2009
- Author(s)
  Tsuji K., Tachikawa M., Akanuma S., Hayashi K., Nishiura A., Hosoya K.
- Organizer
  2009 AAPS Annual Meeting and Exposition
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Localization and transport function of prostaglandin transporter(PGT) in the brain2009
- Author(s)
 Tsuji K., Tachikawa M., Akanuma S., Hayashi K., Nishiura A., Hosoya K.
- Organizer
 8^<th> Cerebral Vascular Biology 2009
- Place of Presentation
 宮城県仙台市
- Data Source
 KAKENHI-PROJECT-21390042
[Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier.2007
- Author(s)
  M. Tachikawa
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  金沢
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Involvement of transporters in the retina-to-blood efflux transport of organic anions at the inner blood-retinal barrier2007
- Author(s)
  K, Hosoya, A. Makihara, Y, Ohshima, K, Katayama, M, Tomi, M, Tachikawa
- Organizer
  29th Symposium on Biomembrane-Drug Interaction
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] The role of scavenger receptor class B type I(SR-BI) in vitamin E uptake at the inner blood-retinal barrier2007
- Author(s)
  S, Okayasu, M, Tachikawa, K, Hosoya
- Organizer
  AAPS annual meeting and exposition
- Place of Presentation
  San Diego
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Creatine transporter functions as guanidinoacetate transporter at the blood-cerebrospinal fluid barrier.2007
- Author(s)
  Tachikawa M.
- Organizer
  3rd Pharmaceutical Science World Congress
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-18790115
[Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier2007
- Author(s)
  M, Tachikawa, M, Toki, M, Tomi, K, Hosoya
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  Kanazawa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] The role of reduced folate transporter1(RTF1) in methyletrahydrofolate transport at the inner blood-retinal barrier2007
- Author(s)
  K, Fujita, M, Tachikawa, K, Hosoya
- Organizer
  AAPS annual meeting and exposition
- Place of Presentation
  San Diego
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier.2007
- Author(s)
  Tachikawa M.
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  Kanazawa
- Data Source
  KAKENHI-PROJECT-18790115
[Presentation] Creatine transporter (CRT/SLC6A8) acting as a guanidino compound transpoter at the blood-cerebrospinal fluid barrier.2007
- Author(s)
  Tachikawa M.
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18790115
[Presentation] A new function of creatine transporter (CRT/SLC6A8) acting as a guanidino compound transporter at the blood-cerebrospinal fluid barrier.2007
- Author(s)
  Tachikawa M.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-18790115
[Presentation] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築
- Author(s)
  立川正憲
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] ヒト血液脳脊髄液関門におけるトランスポータータンパク質発現量及びラットとの種差の解明
- Author(s)
  張正宇、内田康雄、立川正憲、寺崎哲也
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 標的絶対定量プロテオミクスに基づくがん分子標的化学療法の個別・層別化基盤の構築
- Author(s)
  内田康雄、立川正憲、小渕航、大槻純男、中田光俊、濱田潤一郎、寺崎哲也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Invited
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] Dynamic plasticity of “Cluster of differentiation antigen” expressions at the inflammatory blood-brain barrier.
- Author(s)
  Sato K, Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
- Organizer
  19th North American ISSX/29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25670067
[Presentation] Proteomics-based technology as a new path to toxicological evaluation
- Author(s)
  Tachikawa M
- Organizer
  2012 International Symposium on Green Toxicology & Technology: Prediction of Kidney Toxicity
- Place of Presentation
  Seoul, South Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Phosphorylation of actin filament-associated protein as a regulatory mechanism of intrinsic P-glycoprotein transport activity in human brain capillary endothelial cells: A study of LC-MS/MS based-comprehensive and comparative phospho-proteomics.
- Author(s)
  Hoshi Y, Uchida Y, Tachikawa M, Terasaki T
- Organizer
  19th North American ISSX/29th JSSX Meeting,
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能
- Author(s)
  立川正憲、金子洋介、内田康雄、大槻純男、寺崎哲也
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 膜タンパク質を標的とした定量的標的プロテオミクスに基づく悪性脳腫瘍に対する個別化分子標的療法
- Author(s)
  小渕航、大槻純男、中田光俊、内田康雄、立川正憲、濱田潤一郎、寺崎哲也
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] 血液脳関門輸送機能変動因子としてのヘミチャネル
- Author(s)
  立川正憲
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京都文京区
- Invited
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Proteomics-based technology as a new path to toxicological evaluation
- Author(s)
  Tachikawa M
- Organizer
  2012 International Symposium on Green Toxicology & Technology: Prediction of Kidney Toxicity
- Place of Presentation
  Seoul, South Korea
- Invited
- Data Source
  KAKENHI-PROJECT-24659063
[Presentation] Phosphoproteomic approach to clarify regulatory mechanism for intrinsic transport function of one P-glycoprotein molecule at blood-brain barrier: Involvement of tyrosine 14 phosphorylation in caveolin-1.
- Author(s)
  Hoshi Y., Uchida Y., Tachikawa M., Ohstuki S., Terasaki T.
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Pharmacological impact of the brain barrier prostaglandin transport.
- Author(s)
  Tachikawa M.
- Organizer
  20th Annual Blood-Brain Barrier meeting
- Place of Presentation
  Sunriver, Oregon, United States
- Invited
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Quantitative proteomics-based investigation of regulatory mechanism for P-glycoprotein efflux activity at the blood-brain barrier in central nervous system disease: epilepsy and inflammation.
- Author(s)
  Uchida Y., Hoshi Y., Tachikawa M., Ohtsuki S., Terasaki T.
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Transport characteristics of exosomes in human brain capillary endothelial cells.
- Author(s)
  Kuroda H, Tachikawa M, Uchida Y, Terasaki T
- Organizer
  19th North American ISSX/29th JSSX Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier.
- Author(s)
  Tachikawa M
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research
- Author(s)
  Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
- Organizer
  International Gap Junction Conference 2013
- Place of Presentation
  Charleston, South Carolina, United States
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Pharmacological impact of the brain barrier prostaglandin transport
- Author(s)
  Tachikawa M.
- Organizer
  20th Annual Blood-Brain Barrier Consortium Meeting
- Place of Presentation
  Sunriver, Oregon, United States
- Invited
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性
- Author(s)
  立川正憲、金子洋介、赤荻諒、内田康雄、大槻純男、寺崎哲也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Invited
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Involvement of caveolin-1 tyrosine 14 and src tyrosine 419 phosphorylation levels in intrinsic P-glycoprotein transport function at human blood-brain barrier.
- Author(s)
  Hoshi Y,Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
- Organizer
  5th FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] Species difference in transporter protein expression levels at the blood-cerebrospinal fluid barrier between human and rat.
- Author(s)
  Cho S., Uchida Y., Tachikawa M., Terasaki T.
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24249011
[Presentation] ヘミチャネルファミリーを標的とした定量プロテオミクス
- Author(s)
  立川正憲
- Organizer
  日本薬学会東北支部大会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-22689005
[Presentation] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier.
- Author(s)
  Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-22689005

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Tachikawa Masanori 立川 正憲

TACHIKAWA Masanori 立川 正憲

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ヒトウイルス受容体を介した血液脳関門突破機構に基づくエクソソームの脳細胞標的化Principal InvestigatorOngoing

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Investigation of the mechanism and prevention for ischemia-reperfusion injury by using blood-brain barrier-on-a-chipOngoing

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A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expressionOngoing

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「血液くも膜関門排出輸送に基づく中枢解毒」仮説の実証研究Principal InvestigatorOngoing

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新概念高速液流気液界面プラズマによる短寿命活性種バイオサイエンスの基盤確立Ongoing

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Functional coupling of the blood-brain barrier and astrocytes in epilepsyPrincipal Investigator

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Transport systems at the arachnoid barrier cells-forming blood-cerebrospinal fluid barrier.Principal Investigator

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Tachikawa Masanori 立川正憲

TACHIKAWA Masanori 立川正憲