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Tachikawa Masanori  立川 正憲

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TACHIKAWA Masanori  立川 正憲

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Researcher Number 00401810
Other IDs
Affiliation (Current) 2023: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help 2018 – 2023: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
2016 – 2019: 東北大学, 薬学研究科, 准教授
2017: 東北大学, 大学院薬学研究科, 准教授
2012 – 2017: 東北大学, 薬学研究科(研究院), 准教授
2015: 東北大学, 大学院薬学研究科, 准教授 … More
2014: 東北大学, 薬学系研究科, 准教授
2013: 東北大学, 大学院薬学研究科, 准教授
2013: 東北大学, 薬学研究科, 准教授
2011: 東北大学, 大学院・薬学研究科, 准教授
2010: 富山大学, 大学院・医学薬学研究部(薬学), 助教
2007: University of Toyama, Department of Pharmaceutics, Assistant Professor
2006: 富山大学, 大学院医学薬学研究部, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Medium-sized Section 52:General internal medicine and related fields / Biological Sciences / Basic Section 47060:Clinical pharmacy-related / Basic Section 52010:General internal medicine-related
Except Principal Investigator
Medical pharmacy / Digestive surgery / Basic Section 90110:Biomedical engineering-related / Food science / Pediatrics … More / General pharmacology / Neurology / Biological Sciences / Medium-sized Section 14:Plasma science and related fields / Medium-sized Section 52:General internal medicine and related fields / Basic Section 47060:Clinical pharmacy-related Less
Keywords
Principal Investigator
血液脳関門 / トランスポーター / 輸送 / 細胞外小胞 / 血液脳脊髄液関門 / 排出輸送 / 定量プロテオミクス / 輸送系 / 薬学 / 血液くも膜関門 … More / 脳脊髄液 / クレアチン / 痙攣誘発性 / グアニジノ化合物 / 有機カチオン / クレアチニン / グアニジノ酢酸 / ヘミチャネル / 脳毛細血管内皮細胞 / パネキシン / コネキシン / 病態 / 阻害 / 認知症 / 輸送タンパク質 / チャネル / 脳血管障害 / 神経活動 / 活性化 / アストロサイト-血管連関 / 脳血管 / アストロサイト / 脳血管-グリア連関 / 脳神経疾患 / プロテオーム / くも膜 / α-synuclein / くも膜上皮細胞 / 輸送体 / 脳・神経 / 神経変性疾患 / 脳微小血管網 / 三次元脳血管網 / 微小環境 / 薬物送達 / 三次元血管網 / エクソソーム / 脳細胞標的化 / 脳血管-神経ユニット … More
Except Principal Investigator
血液脳関門 / トランスポーター / 血液脳脊髄液関門 / プロスタグランジン / 定量プロテオミクス / 有機アニオン輸送担体 / 脳・神経 / 脳関門 / リン酸化 / 標的絶対定量プロテオミクス / 輸送担体 / 膵癌 / 抗癌剤 / PGE2 / クレアチン / クレアチントランスポーター / oatp / OAT / 薬学 / 血液クモ膜関門 / 血液脊髄関門 / アストロサイト / グリア細胞 / コネキシン / 多発性硬化症 / マイクロ・ナノデバイス / 細胞・組織 / 生物・生体工学 / アミノ酸トランスポター / LAT1 / プロモーター解析 / 糖尿病網膜症 / 血管新生 / Dual-luciferase assay / クリアランス / 脳脊髄液 / P-糖蛋白 / 可塑性 / 病態 / P-糖タンパク / P-glycoprotein / Pharmacoproteomics / 細胞内情報伝達系 / 脳疾患 / 化学療法 / 抗癌剤耐性 / 質量分析 / 膵臓外科学 / 分子標的薬 / 増殖因子受容体 / 個別化医療 / がん / 個別化 / 脳腫瘍 / 受容体 / 脳内炎症 / プロスタグランジン合成酵素 / リポ多糖 / 神経伝達物質 / タンパク質栄養 / 発達期栄養 / 脳機能 / 精神疾患 / 遺伝子発現 / 発達期低栄養 / タンパク質 / アミノ酸 / 脳神経疾患 / 食品 / 分子栄養学 / 栄養学 / 知的障害 / 先天性代謝異常 / 脳クレアチン欠乏症候群 / 治療薬 / 発達障害 / iPS細胞 / グアニジノ化合物 / クレアチニン / グアニジノ酢酸 / 精神遅滞 / 自閉症 / 血液網膜関門 / マイクロダイアリシス法 / 排出輸送 / estradiol17-βglucuronide / ρ-aminohippuric acid / 免疫染色 / p-aminohiuric acid / estradiol 17-β glucuronide / dehydroepiandrosterone sulfate / Oatp / Blood-retinal barrier / Microdialysis / Efflux transport / Estradiol 17-β glucuronide / p-Aminohippuric acid / 癌 / クレアチン脳欠乏症 / 脳クレアチン欠乏症 / 生体機能利用 / SWATH法 / プロテオミクス / タンパク質絶対発現量 / 局在解析 / ヒト / 種差 / 標的定量プロテオミクス / 網羅的半定量プロテオミクス / 網羅的プロテオミクス / 標的プロテオミクス / 血液くも膜関門 / blood-brain barrier / brain barrier / proteomics / transporter / protein quantification / カルシウムシグナル / カルシウムイメージング / 神経保護因子 / 脳損傷 / 反応性アストロサイト / 薬理学 / 神経細胞死 / 神経内分泌腫瘍 / 肝転移 / CNPY2 / 膵神経内分泌腫瘍 / 膵臓 / 転移 / 網膜色素上皮細胞 / 外側血液網膜関門 / ヘミチャネル / Cx43 / Claudin-11 / 密着結合 / 中枢関門 / Claudin11 / グリア / 発生・分化・老化 / 精神・神経疾患の病態と治療 / 気液界面プラズマ / 短寿命活性種 / 高速液流 / マイクロ流路 / 生体分子・細胞反応 / 細胞応答 / 流体工学 / ナノバイオ / 微小血管網 / 虚血再灌流障害 / 多系統萎縮症 / α―シヌクレイン / ミクログリア / アストログリア / 脱髄 / 神経内科疾患 / 脱髄疾患 / シヌクレイン / オリゴデンドログリア / α-シヌクレイン / グリオパチー / グリア標的治療 / 小脳型多系統萎縮症 / 進行型多発性硬化症 / オリゴデンドロサイト / モノカルボン酸トランスポーター / プロドラッグ / MCT / 計測融合シミュレーション Less
  • Research Projects

    (31 results)
  • Research Products

    (267 results)
  • Co-Researchers

    (78 People)
  •  脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性

    • Principal Investigator
      細谷 健一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      University of Toyama
  •  Development of vascular permeability control method by integration of blood-brain barrier-on-a-chip and measurement-integrated simulation

    • Principal Investigator
      船本 健一
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Tohoku University
  •  脳血管-神経ユニット・胎盤エクソソーム輸送系を軸とした胎盤-脳連関機構解明と応用Principal Investigator

    • Principal Investigator
      立川 正憲
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      The University of Tokushima
  •  金魚免疫系×ヒトモデル化血液脳関門チップで変革する中枢送達型抗体開発Principal Investigator

    • Principal Investigator
      立川 正憲
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      The University of Tokushima
  •  A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression

    • Principal Investigator
      吉良 潤一
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      International University of Health and Welfare
      Kyushu University
  •  Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification systemPrincipal Investigator

    • Principal Investigator
      TACHIKAWA Masanori
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      The University of Tokushima
  •  ヒトウイルス受容体を介した血液脳関門突破機構に基づくエクソソームの脳細胞標的化Principal Investigator

    • Principal Investigator
      立川 正憲
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      The University of Tokushima
  •  Investigation of the mechanism and prevention for ischemia-reperfusion injury by using blood-brain barrier-on-a-chip

    • Principal Investigator
      Funamoto Kenichi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Tohoku University
  •  Establishment of the basis for bioscience of short-lived reactive species using a new concept of gas-liquid interfacial plasma with high-speed liquid flow

    • Principal Investigator
      KANEKO Toshiro
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 14:Plasma science and related fields
    • Research Institution
      Tohoku University
  •  Study of human brain barrier transport mechanism based global and targeted proteomics

    • Principal Investigator
      Terasaki Tetsuya
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Functional coupling of the blood-brain barrier and astrocytes in epilepsyPrincipal Investigator

    • Principal Investigator
      立川 正憲
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Transport systems at the arachnoid barrier cells-forming blood-cerebrospinal fluid barrier.Principal Investigator

    • Principal Investigator
      TACHIKAWA Masanori
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      The University of Tokushima
      Tohoku University
  •  Development of order-made therapy for pancreatic cancer controlling of crosstalk between cancer cell and cancer associated fibroblast

    • Principal Investigator
      Motoi Fuyuhiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Amino acid transporter-based drug development for cerebral creatine deficiency syndrome

    • Principal Investigator
      Terasaki Tetsuya
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.

    • Principal Investigator
      HOSOYA Ken-ichi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Investigation of contribution of novel tight junction molecule at the two big central nervous system barriers and its usefulness as a therapeutic target for multiple sclerosis

    • Principal Investigator
      Uchida Yasuo
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tohoku University
  •  Screening and analysis of glial factors for neuroprotection

    • Principal Investigator
      Kanemaru Kazunori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      The University of Tokyo
  •  Elucidation of molecular mechanism in liver metastasis of gastroenteropancreatic neuroendocrine tumors

    • Principal Investigator
      Mizuma Masamichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange

    • Principal Investigator
      IKENAKA Kazuhiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute for Physiological Sciences
  •  Early protein restriction impacts gene/protein expression and function in mature brain

    • Principal Investigator
      FURUYA Shigeki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Food science
    • Research Institution
      Kyushu University
  •  Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes

    • Principal Investigator
      WADA Takahito
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Retrieval of blood-brain barrier transport function towards dementia preventionPrincipal Investigator

    • Principal Investigator
      Tachikawa Masanori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Clarification of molecular mechanisms of the blood-brain barrier plasticity based on quantitative targeted absolute proteomics

    • Principal Investigator
      Terasaki Tetsuya
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Development of order-made therapy for pancreatic cancer based on quantitative proteomics and metabolomics archive

    • Principal Investigator
      MOTOI Fuyuhiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy

    • Principal Investigator
      TERASAKI TETSUYA
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases

    • Principal Investigator
      HOSOYA Ken-ichi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Pathophysiological role of the blood-brain barrier hemichannels and molecular-targeted diagnosis and therapyPrincipal Investigator

    • Principal Investigator
      TACHIKAWA MASANORI
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
      University of Toyama
  •  Molecular identification and physiological role of brain-type prostaglandin transporter

    • Principal Investigator
      HOSOYA Ken-ichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  アミノ酸トランスポーター遺伝子の転写活性調節による網膜血管新生阻害法の開発

    • Principal Investigator
      HOSOYA Ken-ichi
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  脳関門輸送系による痙攣誘発性物質の中枢障害回避機構Principal Investigator

    • Principal Investigator
      立川 正憲
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Physiological role of retina-to-blood efflux transport at the inner blood-retinal barrier

    • Principal Investigator
      HOSOYA Kenichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

  • [Book] Plasma Medical Science, pp.175-1902018

    • Author(s)
      T. Kaneko, S. Sasaki, K. Takashima, M. Kanzaki, M. Tachikawa, H. Kanetaka, T. Sato, M.G. Kong
    • Total Pages
      458
    • Publisher
      Elsevier
    • ISBN
      9780128150047
    • Data Source
      KAKENHI-PROJECT-18H03687
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Book] Recent progress in the blood-brain barrier and the blood-CSF barrier transport research : Pharmaceutical relevance of drug delivery to the brain. Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014

    • Author(s)
      Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Publisher
      Springer, New York
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Book] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain–Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Publisher
      Springer, New York
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Book] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Publisher
      Springer, New York
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Book] Systemic route for retinal drug delivery : role of the blood-retinal barrier transporters. Drug Product Development for the Back of the Eye, Kompella U. B. and Edelhauser H. F. (Ed), American Association of Pharmaceutical Scientists2011

    • Author(s)
      Tachikawa M, Ganapathy V, Hosoya K
    • Publisher
      Press-Springer, New York
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Book] Systemic route for retinal drug delivery : role of the blood-retinal barrier, In Drug Product Development for the Back of the Eye2011

    • Author(s)
      Tachikawa M., Ganapathy V., Hosoya K.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Book] Creative and Creatine Kinase in Health and Disease2007

    • Author(s)
      Tachikawa M.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Journal Article] Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells2020

    • Author(s)
      Tachikawa Masanori、Murakami Koji、Akaogi Ryo、Akanuma Shin-ichi、Terasaki Tetsuya、Hosoya Ken-ichi
    • Journal Title

      Neurochemistry International

      Volume: 132 Pages: 104600-104600

    • DOI

      10.1016/j.neuint.2019.104600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Journal Article] Distinct Transport Properties of Human Pannexin 1 and Connexin 32 Hemichannels.2020

    • Author(s)
      Tachikawa M, Akaogi R, Taii A, Akanuma SI, Uchida Y, Terasaki T.
    • Journal Title

      J Pharm Sci.

      Volume: 109(3) Issue: 3 Pages: 1395-1402

    • DOI

      10.1016/j.xphs.2019.12.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-19H03390
  • [Journal Article] Abundant Expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1, and xCT Transporters in Blood-Arachnoid Barrier of Pig and Polarized Localizations at CSF- and Blood-Facing Plasma Membranes.2020

    • Author(s)
      Uchida Y, Goto R, Takeuchi H, Luczak M, Usui T, Tachikawa M, Terasaki T.
    • Journal Title

      Drug Metab Dispos

      Volume: 48(2) Issue: 2 Pages: 135-145

    • DOI

      10.1124/dmd.119.089516

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22590, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-19K16438
  • [Journal Article] Continuous release of O2/ONOO in plasma‐exposed HEPES‐buffered saline promotes TRP channel‐mediated uptake of a large cation2020

    • Author(s)
      Sasaki Shota、Zheng Yuexing、Mokudai Takayuki、Kanetaka Hiroyasu、Tachikawa Masanori、Kanzaki Makoto、Kaneko Toshiro
    • Journal Title

      Plasma Processes and Polymers

      Volume: 17 Issue: 10 Pages: 1900257-1900257

    • DOI

      10.1002/ppap.201900257

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17791, KAKENHI-PROJECT-18H03687, KAKENHI-PROJECT-19K14698, KAKENHI-PROJECT-20H04118
  • [Journal Article] Targeted Proteomics-Based Quantitative Protein Atlas of Pannexin and Connexin Subtypes in Mouse and Human Tissues and Cancer Cell Lines.2020

    • Author(s)
      Tachikawa M, Kaneko Y, Ohtsuki S, Uchida Y, Watanabe M, Ohtsuka H, Terasaki T.
    • Journal Title

      J Pharm Sci.

      Volume: 109(2) Issue: 2 Pages: 1161-1168

    • DOI

      10.1016/j.xphs.2019.09.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-19H03390
  • [Journal Article] Selective Protein Expression Changes of Leukocyte-Migration-Associated Cluster of Differentiation Antigens at the Blood–Brain Barrier in a Lipopolysaccharide-Induced Systemic Inflammation Mouse Model without Alteration of Transporters, Receptors or Tight Junction-Related Protein2019

    • Author(s)
      Sato K, Tachikawa M, Watanabe M, Uchida Y, Terasaki T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 6 Pages: 944-953

    • DOI

      10.1248/bpb.b18-00939

    • NAID

      130007657682

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-06-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
  • [Journal Article] Identification of blood-brain barrier-permeable proteins derived from peripheral organ: In vivo and in vitro evidence of blood-to-brain transport of creatine kinase2019

    • Author(s)
      Sato K, Tachikawa M, Watanabe M, Miyauchi E, Uchida Y, Terasaki T
    • Journal Title

      Mol Pharm

      Volume: - Issue: 1 Pages: 247-257

    • DOI

      10.1021/acs.molpharmaceut.8b00975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16J02046, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004
  • [Journal Article] Cluster of Differentiation 46 is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)2019

    • Author(s)
      Kuroda H, Tachikawa M, Yagi Y, Umetsu M, Nurdin A, Miyauchi E, Watanabe M, Uchida Y, Terasaki T.
    • Journal Title

      Mol. Pharm.

      Volume: 16 Issue: 1 Pages: 292-304

    • DOI

      10.1021/acs.molpharmaceut.8b00985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16J02928, KAKENHI-PUBLICLY-18H04534
  • [Journal Article] Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood-brain barrier transporters2019

    • Author(s)
      Hoshi Yutaro、Uchida Yasuo、Kuroda Takashi、Tachikawa Masanori、Couraud Pierre-Olivier、Suzuki Takashi、Terasaki Tetsuya
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: - Issue: 7 Pages: 1533-1545

    • DOI

      10.1177/0271678x19868880

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
  • [Journal Article] Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood-brain barrier2019

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: - Issue: 2 Pages: 420-436

    • DOI

      10.1177/0271678x18822801

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-17H04004
  • [Journal Article] Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis2019

    • Author(s)
      Uchida Y, Sumiya T, Tachikawa M, Yamakawa T, Murata S, Yagi Y, Sato K, Stephan A, Ito K, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T.
    • Journal Title

      Mol. Neurobiol,

      Volume: 56 Issue: 3 Pages: 2039-2056

    • DOI

      10.1007/s12035-018-1207-5

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218, KAKENHI-PUBLICLY-18H04534
  • [Journal Article] Organic Anion Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats2019

    • Author(s)
      Yaguchi Y, Tachikawa M, Zhang Z, Terasaki T.
    • Journal Title

      Mol Pharm

      Volume: 16(5) Issue: 5 Pages: 2021-2027

    • DOI

      10.1021/acs.molpharmaceut.9b00005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Journal Article] Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.2019

    • Author(s)
      Hellinen L, Sato K, Reinisalo M, Kidron H, Rilla K, Tachikawa M, Uchida Y, Terasaki T, Urtti A.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 60(15) Issue: 15 Pages: 5022-5034

    • DOI

      10.1167/iovs.19-27328

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22590, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
  • [Journal Article] Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells.2019

    • Author(s)
      Ochiai Y, Uchida Y, Tachikawa M, Couraud PO, Terasaki T.
    • Journal Title

      J Neurochem.

      Volume: 150(4) Issue: 4 Pages: 385-401

    • DOI

      10.1111/jnc.14722

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22590, KAKENHI-PROJECT-18KK0446, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-17H04004, KAKENHI-PROJECT-16H06218
  • [Journal Article] Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels2018

    • Author(s)
      Tachikawa M, Toki H, Watanabe M, Tomi M, Hosoya K, Terasaki T.
    • Journal Title

      Anat Sci Int

      Volume: - Issue: 4 Pages: 456-463

    • DOI

      10.1007/s12565-018-0435-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08364, KAKENHI-PUBLICLY-16H01326, KAKENHI-WRAPUP-18H05199
  • [Journal Article] Cell-type-specific spatiotemporal expression of creatine biosynthetic enzyme S-adenosylmethionine: guanidinoacetate N-methyltransferase in developing mouse brain2018

    • Author(s)
      Tachikawa M, Watanabe M, Fukaya M, Sakai K, Terasaki T, Hosoya K.
    • Journal Title

      Neurochem Res

      Volume: 43 Issue: 2 Pages: 500-510

    • DOI

      10.1007/s11064-017-2446-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15153
  • [Journal Article] Assembly of Taurine Transporter (Slc6a6) with Na<sup>+</sup>–H<sup>+</sup> Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity2018

    • Author(s)
      Tachikawa M, Yokoyama R, Akanuma SI, Hosoya K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 3 Pages: 338-341

    • DOI

      10.1248/bpb.b17-00664

    • NAID

      130006407354

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-16H01326
  • [Journal Article] Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins.2018

    • Author(s)
      Akanuma S., Higashi H., Maruyama S., Murakami K., Tachikawa M., Kubo Y., Hosoya K.
    • Journal Title

      Exp. Eye Res.

      Volume: 168 Pages: 128-37

    • DOI

      10.1016/j.exer.2018.01.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08365, KAKENHI-PROJECT-16H05110, KAKENHI-PROJECT-16K15157
  • [Journal Article] Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain2018

    • Author(s)
      Tachikawa Masanori、Yashiki Ayane、Akanuma Shin-ichi、Matsukawa Haruka、Ide Soichiro、Minami Masabumi、Hosoya Ken-ichi
    • Journal Title

      Neurochem Int.

      Volume: 113 Pages: 1-7

    • DOI

      10.1016/j.neuint.2017.11.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08612, KAKENHI-PROJECT-16K15153
  • [Journal Article] Drug clearance from cerebrospinal fluid mediated by organic anion transporters 1 (Slc22a6) and 3 (Slc22a8) at arachnoid membrane of rats.2018

    • Author(s)
      Zhang Z, Tachikawa M, Uchida Y, Terasaki T.
    • Journal Title

      Mol Pharm

      Volume: 15(3) Issue: 3 Pages: 911-922

    • DOI

      10.1021/acs.molpharmaceut.7b00852

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08364, KAKENHI-PROJECT-16H06218
  • [Journal Article] Inner blood-retinal barrier dominantly expresses breast cancer resistance protein: Comparative quantitative targeted absolute proteomics (QTAP) study of CNS barriers in pig2017

    • Author(s)
      Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S, Hosoya K, Urtti A, Terasaki T, Tachikawa M
    • Journal Title

      Mol Pharm

      Volume: 14 Issue: 11 Pages: 3729-3738

    • DOI

      10.1021/acs.molpharmaceut.7b00493

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16K15475
  • [Journal Article] Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells.2017

    • Author(s)
      Yutaro Hoshi, Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki, Tetsuya Terasaki
    • Journal Title

      Journal of Neurochemistry

      Volume: 印刷中 Issue: 2 Pages: 247-262

    • DOI

      10.1111/jnc.13960

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-14J06383, KAKENHI-PROJECT-16H06218, KAKENHI-PROJECT-16K15475
  • [Journal Article] Abnormal <i>N</i>-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization2017

    • Author(s)
      T. Uemura, S. Ito, Y. Ohta, M. Tachikawa, T. Wada, T. Terasaki, S. Ohtsuki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 1 Pages: 49-55

    • DOI

      10.1248/bpb.b16-00582

    • NAID

      130005188881

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293035, KAKENHI-PROJECT-26461544
  • [Journal Article] 脳脊髄液中物質動態における脳脊髄液と接する関門の役割:脈絡叢上皮細胞、クモ膜上皮細胞、脊髄毛細血管内皮細胞における細胞膜輸送2017

    • Author(s)
      張正宇、立川正憲、寺崎哲也
    • Journal Title

      神経内科Neurological Medicine

      Volume: 87 Pages: 253-263

    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Journal Article] Quantitative Targeted Absolute Proteomics of Rat Blood-Cerebrospinal Fluid Barrier Transporters: Comparison with a Human Specimen.2015

    • Author(s)
      Uchida Y, Zhang Z, Tachikawa M, Terasaki T.
    • Journal Title

      J Neurochem

      Volume: 134 Issue: 6 Pages: 1104-1115

    • DOI

      10.1111/jnc.13147

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Journal Article] Distribution of microsomal prostaglandin E synthase-1 in the mouse brain2014

    • Author(s)
      Eskilsson A., Tachikawa M., Hosoya K., Blomqvist A.
    • Journal Title

      J. Comp. Neurol.

      Volume: (印刷中) Issue: 14 Pages: 3229-3244

    • DOI

      10.1002/cne.23593

    • Year and Date
      2014-04-08
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659072
  • [Journal Article] Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells.2014

    • Author(s)
      Ito S, Ohtsuki S, Murata S, Katsukura Y, Suzuki H, Funaki M, Tachikawa M, Terasaki T
    • Journal Title

      J Alzheimers Dis

      Volume: 38 Issue: 1 Pages: 185-200

    • DOI

      10.3233/jad-122077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Journal Article] Quantitative targeted proteomics for understanding the blood-brain barrier : towards pharmacoproteomics2014

    • Author(s)
      Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T
    • Journal Title

      Expert Rev Proteomics

      Volume: (in press) Issue: 3 Pages: 303-313

    • DOI

      10.1586/14789450.2014.893830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.2014

    • Author(s)
      Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T
    • Journal Title

      Expert Rev Proteomics

      Volume: 11 Pages: 303-313

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Journal Article] Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers.2014

    • Author(s)
      Tachikawa M, Hosoya K, Terasaki T
    • Journal Title

      Adv Pharmacol

      Volume: 71 Pages: 337-360

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Journal Article] Pharmacokinetics of guanidinosuccinic acid in rat blood and cerebrospinal fluid.2014

    • Author(s)
      Kasai Y, Akanuma SI, Kubo Y, Tachikawa M, Hosoya K
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 29 Pages: 97-100

    • NAID

      130004463342

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Journal Article] A Study Protocol for Quantitative Targeted Absolute Proteomics (QTAP) by LC-MS/MS: Application for Inter-Strain Differences in Protein Expression Levels of Transporters, Receptors, Claudin-5, and Marker Proteins at the Blood-Brain Barrier in ddY, FVB, and C57BL/6J mice.2013

    • Author(s)
      Y Uchida, M Tachikawa, W Obuchi, Y Hoshi, Y Tomioka, S Ohtsuki, T Terasaki
    • Journal Title

      Fluids Barriers CNS

      Volume: 10 Issue: 1 Pages: 21-21

    • DOI

      10.1186/2045-8118-10-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011, KAKENHI-PROJECT-25670067
  • [Journal Article] 血液脳関門トランスポートソームの定量的絶対発現プロファイル : 動物種間, 系統間, 野生型-遺伝子欠損マウス間の相違性と類似性2013

    • Author(s)
      内田康雄, 立川正憲, 星裕太朗, 寺崎哲也
    • Journal Title

      脳21

      Volume: 16 Pages: 46-52

    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice2013

    • Author(s)
      Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
    • Journal Title

      Fluids Barriers CNS

      Volume: 10(1) Pages: 21-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Quantitative Expression of Human Drug Transporter Proteins in Lung Tissues : Analysis of Regional, Gender and Inter-individual differences by Liquid Chromatography-Tandem Mass Spectrometry. E-pub ahead of print2013

    • Author(s)
      Sakamoto A, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Journal Title

      J Pharm Sci

      Volume: 102(9) Pages: 3395-3406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Journal Article] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset.2013

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T
    • Journal Title

      J Pharm Sci

      Volume: 102 Issue: 9 Pages: 3343-3355

    • DOI

      10.1002/jps.23575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011, KAKENHI-PROJECT-25670067
  • [Journal Article] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model2013

    • Author(s)
      Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T
    • Journal Title

      Mol Pharm

      Volume: 10 Pages: 289-296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Quantitative expression of human drug transporter proteins in lung tissues: Analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry.2013

    • Author(s)
      Sakamoto A, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Journal Title

      J. Pharm. Sci.

      Volume: 102 Issue: 9 Pages: 3395-3406

    • DOI

      10.1002/jps.23606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011
  • [Journal Article] A Study Protocol for Quantitative Targeted Absolute Proteomics (QTAP) by LC-MS/MS : Application for Inter-Strain Differences in Protein Expression Levels of Transporters, Receptors, Claudin-5, and Marker Proteins at the Blood-Brain Barrier in ddY, FVB, and C57BL/6J mice2013

    • Author(s)
      Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 10(1) Pages: 21-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Journal Article] 動的インターフェースとしての脳関門輸送システムと脳関門生理学・創薬研究2013

    • Author(s)
      立川正憲, 内田康雄, 寺崎哲也
    • Journal Title

      BRAIN and NERVE

      Volume: 65 Pages: 121-137

    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset2013

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T
    • Journal Title

      J Pharm Sci

      Volume: 102 Pages: 3343-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] 血液脳関門トランスポートソームの定量的絶対発現プロファイル:動物種間,系統間,野生型-遺伝子欠損マウス間の相違性と類似性2013

    • Author(s)
      内田康雄、立川正憲、星裕太朗、寺崎哲也
    • Journal Title

      脳21

      Volume: 16 Pages: 46-52

    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] 標的絶対定量プロテオミクスが拓くヒト血液脳関門輸送機能研究2013

    • Author(s)
      立川正憲, 内田康雄, 寺崎哲也
    • Journal Title

      Drug Delivery System

      Volume: 28 Pages: 270-278

    • NAID

      130003384377

    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid : role of the blood-cerebrospinal barrier transporters2012

    • Author(s)
      Tachikawa M, Tsuji K, Yokoyama R, Higuchi T, Ozeki G, Yashiki A, Akanuma S, Hayashi K, Nishiura A, Hosoya K
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 343 Pages: 608-616

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E_2 produced in the brain2012

    • Author(s)
      Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K
    • Journal Title

      J Neurochem

      Volume: 12 Pages: 750-760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain.2012

    • Author(s)
      Tachikawa M
    • Journal Title

      J Neurochem

      Volume: 123 Issue: 5 Pages: 750-760

    • DOI

      10.1111/jnc.12018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-24659072
  • [Journal Article] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model.2012

    • Author(s)
      Ohtsuki S
    • Journal Title

      Mol Pharm

      Volume: 10 Issue: 1 Pages: 289-296

    • DOI

      10.1021/mp3004308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-23790170, KAKENHI-PROJECT-24249011, KAKENHI-PROJECT-25670067
  • [Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.2012

    • Author(s)
      Tachikawa M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 343 Issue: 3 Pages: 608-616

    • DOI

      10.1124/jpet.112.197012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-24659072
  • [Journal Article] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier2011

    • Author(s)
      Tachikawa M, Murakami K, Martin P, Hosoya K, Ganapathy V
    • Journal Title

      Microvas Res

      Volume: 82 Pages: 385-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins2011

    • Author(s)
      Hosoya K, Tachikawa M
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Pages: 478-485

    • NAID

      10029571602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] The inner blood-retinal barrier mediates L-isomer-predominant transport of serine2011

    • Author(s)
      Tachikawa M., Okamoto M., et al
    • Journal Title

      J Pharm Sci

      Volume: 100 Issue: 9 Pages: 3892-3903

    • DOI

      10.1002/jps.22626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Transport systems of serine at the brain barriers and in brain parenchymal cells2011

    • Author(s)
      Kasai Y., Tachikawa M., Hirose S., Akanuma S., Hosoya K.
    • Journal Title

      J. Neurochem

      Volume: 118 Issue: 2 Pages: 304-13

    • DOI

      10.1111/j.1471-4159.2011.07313.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22689005
  • [Journal Article] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins2011

    • Author(s)
      Hosoya K., Tachikawa M.
    • Journal Title

      Clin. Exp. Nephrol.

      Volume: 15 Issue: 4 Pages: 478-85

    • DOI

      10.1007/s10157-011-0460-y

    • NAID

      10029571602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Journal Article] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier2011

    • Author(s)
      Tachikawa M., Murakami K., et al
    • Journal Title

      Microvasc Res

      Volume: 82 Issue: 3 Pages: 385-390

    • DOI

      10.1016/j.mvr.2011.06.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Attenuation of prostaglandin E_2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole2011

    • Author(s)
      Akanuma S., Uchida Y., Ohtsuki S., Kamiie J., Tachikawa M., Terasaki T., Hosoya K.
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Issue: 1 Pages: 24-24

    • DOI

      10.1186/2045-8118-8-24

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150, KAKENHI-PROJECT-23790170
  • [Journal Article] 定量的絶対標的プロテオミクスに基づくヒト血液脳関門におけるトランスポーターの発現と生理機能2011

    • Author(s)
      立川正憲, 内田康雄, 大槻純男, 寺崎哲也
    • Journal Title

      脳21

      Volume: 14 Pages: 42-48

    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Molecular-weight-dependent, Anionic-substrate-preferential Transport of .BETA.-Lactam Antibiotics via Multidrug Resistance-associated Protein 42011

    • Author(s)
      Akanuma S., Uchida Y., Ohtsuki S., Kamiie J., Tachikawa M., Terasaki T., Hosoya K.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 26 Issue: 6 Pages: 602-611

    • DOI

      10.2133/dmpk.DMPK-11-RG-063

    • NAID

      130004933500

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150, KAKENHI-PROJECT-23790170
  • [Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.2011

    • Author(s)
      Tachikawa M.
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Pages: 13-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Hypertonicity Enhances GABA Uptake by Cultured Rat Retinal Capillary Endothelial Cells2011

    • Author(s)
      Yahara T, Tachikawa M, Akanuma S, Hosoya K
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25 Pages: 611-615

    • NAID

      10027744026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Amyloid-βpeptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011

    • Author(s)
      Fujiyoshi M., Tachikawa M., Ohtsuki S., Ito S., Uchida Y., Akanuma S., Kamiie J., Hashimoto T., Hosoya K., Iwatsubo T., Terasaki T.
    • Journal Title

      J. Neurochem.

      Volume: 118 Issue: 3 Pages: 407-15

    • DOI

      10.1111/j.1471-4159.2011.07311.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-23790170
  • [Journal Article] Strategies for therapy of retinal diseases using systemic drug delivery : relevance of transporters at the blood-retinal barrier2011

    • Author(s)
      Hosoya K, Tomi M, Tachikawa M
    • Journal Title

      Expert Opin Drug Deliv

      Volume: 8 Pages: 1571-1587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011

    • Author(s)
      Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T
    • Journal Title

      J Neurochem

      Volume: 118 Pages: 407-415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders2011

    • Author(s)
      Tachikawa M, Hosoya K
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Pages: 13-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders2011

    • Author(s)
      Tachikawa M., Hosoya K.
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Issue: 1 Pages: 13-13

    • DOI

      10.1186/2045-8118-8-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Journal Article] The Inner Blood-Retinal Barrier Mediates L-Isomer-Predominant Transport of Serine2011

    • Author(s)
      Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma S, Terasaki T, Hosoya K
    • Journal Title

      J Pharm Sci

      Volume: 100 Pages: 3892-903

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.2011

    • Author(s)
      Tachikawa M., Hosoya K.
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Pages: 1-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Journal Article] Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E_2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins2010

    • Author(s)
      Akanuma S., Hosoya K., Ito S., Tachikawa M., Terasaki T, Ohtsuki S.
    • Journal Title

      J. Pharmacol. Exp. Ther.

      Volume: 333 Issue: 3 Pages: 912-9

    • DOI

      10.1124/jpet.109.165332

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150
  • [Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability2010

    • Author(s)
      Hosoya K, Yamamoto A, Akanuma S, Tachikawa M
    • Journal Title

      Pharm Res

      Volume: 27 Pages: 2715-2724

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability2010

    • Author(s)
      Hosoya K., Yamamoto A., Akanuma S., Tachikawa M.
    • Journal Title

      Pharm. Res

      Volume: 27 Issue: 12 Pages: 2715-24

    • DOI

      10.1007/s11095-010-0272-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells.2008

    • Author(s)
      Tachikawa M.
    • Journal Title

      Microvascular Research 75

      Pages: 68-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008

    • Author(s)
      M, Tachikawa, H, Toki, M, Tomi, K, Hosoya
    • Journal Title

      Microvasc. Res 75

      Pages: 68-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008

    • Author(s)
      M. Tachikawa
    • Journal Title

      Microvasc. Res. 75

      Pages: 68-72

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008

    • Author(s)
      M. Tachikawa
    • Journal Title

      Microvasc. Res 75

      Pages: 68-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Na^+-independent choline transport in rat retinal capillary endothelial cells2007

    • Author(s)
      M, Tomi, K, Arai, M, Tachikawa, K, Hosoya
    • Journal Title

      Neurochem. Res 32

      Pages: 1833-1842

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of α-tocopherol using cultured rat retinal capillary endothelial cells.2007

    • Author(s)
      M. Tachikawa
    • Journal Title

      Mol. Vis. 13

      Pages: 2041-2047

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of α-tocopherol using cultured rat retinal capillary endothelihal cells.2007

    • Author(s)
      Tachikawa M.
    • Journal Title

      Molecular Vision 13

      Pages: 2041-2047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Journal Article] Functional involvement of scavenger receptor class B, type I, in the upt ake of α-tocopherol using cultured rat retinal capillary endothelial cells2007

    • Author(s)
      M. Tachikawa
    • Journal Title

      Mol. Vis 13

      Pages: 2041-2047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of a-tocopherol using cultured rat retinal capillary endothelial cells2007

    • Author(s)
      M, Tachikawa, S, Okayasu, K, Hosoya
    • Journal Title

      Mol. Vis 13

      Pages: 2041-2047

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Journal Article] Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier2006

    • Author(s)
      K, Nagase, M, Tomi, M, Tachikawa, K, Hosoya
    • Journal Title

      Biochim. Biophys. Acta 1758

      Pages: 13-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Presentation] マイクロ流体デバイスを用いた三次元ヒト脳微小血管網の構築2022

    • Author(s)
      佐藤桃子、稲垣舞、酒巻祐花、船本健一、立川正憲
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] ヒト血液脳関門における細胞外小胞輸送システムの多様性と特異性2022

    • Author(s)
      立川正憲
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] Reconstruction of perfusable human 3D microvasculature on a chip as an evaluation model of cancer cell extravasation and drug transport2021

    • Author(s)
      Yuka Sakamaki、Mai Inagaki、Momoko Sato、Kenichi Funamoto、Masanori Tachikawa
    • Organizer
      The 21st International Symposium on Advanced Fluid Information (AFI-2021)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04435
  • [Presentation] 網羅的プロテオミクスを用いたヒト脳毛細血管内皮細胞への内在化活性を示す脳転移性メラノーマSK-Mel-28由来細胞外小胞の特性解析2021

    • Author(s)
      木下暢、大野大樹、小迫英尊、稲垣舞、立川正憲
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] マイクロ流体デバイスを用いた灌流性を有する三次元ヒト微小血管網の再構築2021

    • Author(s)
      酒巻 祐花、稲垣 舞、佐藤 桃子、船本 健一、立川 正憲
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-19H04435
  • [Presentation] 定量プロテオミクスが拓いた脳関門物流システム-Brain Barrier Logistics-解明研究2021

    • Author(s)
      立川正憲
    • Organizer
      第14回日本薬物動態学会ショートコース
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] 中分子環状デプシペプチドDestruxin Eの細胞膜輸送・細胞内代謝・分子標的V-ATPase阻害における立体特異性の解明2021

    • Author(s)
      網藤惇、今野源、吉田将人、土井隆行、稲垣舞、寺崎哲也、立川正憲
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] Reconstruction of 3D human brain microvasculature on a chip using brain endothelial cells, astrocytes and pericytes2021

    • Author(s)
      Sato M, Inagaki M, Sakamaki Y, Funamoto K, Tachikawa M
    • Organizer
      Eighteenth International Conference on Flow Dynamics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] Reconstruction of perfusable human 3D microvasculature on a chip as an evaluation model of cancer cell extravasation and drug transport2021

    • Author(s)
      Sakamaki Y, Inagaki M, Sato M, Funamoto K, Tachikawa M
    • Organizer
      Eighteenth International Conference on Flow Dynamics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] 末梢から中枢への情報伝達制御装置としての血液脳関門物流システムの役割と脳への薬物送達2021

    • Author(s)
      立川正憲、稲垣舞
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] 定量プロテオミクス解析から見えてきた中枢-免疫インターフェースとしての血液脳関門の役割2021

    • Author(s)
      立川正憲
    • Organizer
      第44回日本神経科学会
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] Reconstruction of 3D human brain microvasculature on a chip using brain endothelial cells, astrocytes and pericytes2021

    • Author(s)
      Momoko Sato、Mai Inagaki、Yuka Sakamaki、Kenichi Funamoto、Masanori Tachikawa
    • Organizer
      The 18th International Conference on Flow Dynamics (ICFD2021)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04435
  • [Presentation] ヒト胎盤絨毛細胞株BeWo細胞由来エクソソームのヒト脳血管内皮細胞 (hCMEC/D3)への内在化2021

    • Author(s)
      稲垣舞,佐野陽乃里,中野瑛介,登美斉俊,立川正憲
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] 脳内クリアランスシステムとしての血液くも膜関門輸送系の役割2020

    • Author(s)
      立川正憲
    • Organizer
      第43回日本神経科学会
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] 定量プロテオミクスで解き明かす血液脳関門・血液くも膜関門2020

    • Author(s)
      立川正憲
    • Organizer
      第39回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] SWATH定量プロテオミクスに基づくヒト小児てんかんの焦点部位における血液脳関門と脳実質組織の病態変動機構の網羅的解明2020

    • Author(s)
      佐藤理沙、内田康雄、大森広太郎、梅津美奈、Gerald Grant、Brenda Porter、Anthony Bet、立川正憲、臼井拓也、寺崎哲也
    • Organizer
      日本薬学会 第140年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 定量プロテオミクスで解き明かす血液脳関門・血液くも膜関門2020

    • Author(s)
      立川正憲
    • Organizer
      第39回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] 3D Human Blood-Brain Barrier Chip for Central Nervous System Drug Development2020

    • Author(s)
      Sato M,Sakamaki Y,Inagaki M,Funamoto K,Tachikawa M
    • Organizer
      Seventeenth International Conference on Flow Dynamics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] 薬剤耐性型てんかん患者の血液脳関門で薬物代謝酵素が発現上昇する。2019

    • Author(s)
      佐藤理沙、内田康雄、大森広太郎、梅津美奈、Gerald Grant、Brenda Porter、Anthony Bet、立川正憲、臼井拓也、寺崎哲也
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開2019

    • Author(s)
      立川正憲
    • Organizer
      第41回神経組織培養研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] 中枢関門科学:Connecting the human dots2019

    • Author(s)
      立川正憲
    • Organizer
      第13回次世代を担う若手医療薬科学シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] Blood-brain barrier-permeable proteins and transport characteristics in brain endothelial cells2019

    • Author(s)
      Tachikawa M, Terasaki T
    • Organizer
      日本薬物動態学会第34年会
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] 膜タンパク質に対する網羅的なタンパク質絶対定量法 “QGAP 法 ” の開発:ヒト血液脳関門における網羅的な絶対発現量アトラス2019

    • Author(s)
      平野誠巳, 内田康雄, 梅津美奈, 後藤諒平, 八木悠太, 立川正憲, 田野光敏, 高尾昌樹, 寺崎哲也
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Anti-epileptic drug metabolizing enzymes are upregulated at the blood-brain barrier in pharmacoresistant childhood epilepsy: SWATH-based comprehensive quantitative proteomic study2019

    • Author(s)
      R Sato, Y Uchida, K Omori, M Umetsu, G Grant, B Porter, A Bet, M Tachikawa, T Usui, and T Terasaki
    • Organizer
      34th JSSX annual conference
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Blood-brain barrier-permeable proteins and transport characteristics in brain endothelial cells2019

    • Author(s)
      Tachikawa M, Terasaki T
    • Organizer
      日本薬物動態学会第34年会
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] (口頭発表部門で優秀発表賞を受賞) 脈絡叢と脳軟髄膜の標的プロテオミクス解析:ブタ1 頭あたりの脈絡叢と脳軟髄膜におけるトランスポータータンパク質の発現量解析と膜タンパク質の膜局在の網羅的解明2019

    • Author(s)
      後藤諒平、内田康雄、竹内妃奈、Magdalena Luczak、臼井拓也、立川正憲、寺崎哲也
    • Organizer
      第41回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 中枢関門科学:Connecting the human dots2019

    • Author(s)
      立川正憲
    • Organizer
      第13回次世代を担う若手医療薬科学シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] The human-specific virus receptor CD46 makes a major contribution to the internalization of brain-metastatic melanoma-derived exosomes by human blood-brain barrier endothelial cells.2019

    • Author(s)
      Tachikawa M, Kuroda H, Watanabe M, Uchida Y, Terasaki T
    • Organizer
      13th International Conference of Cerebral Vascular Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03390
  • [Presentation] ヒト血液脳関門における脳転移性メラノーマ由来エクソソームの輸送機構と種差2019

    • Author(s)
      立川正憲、寺崎哲也
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] 定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開2019

    • Author(s)
      立川正憲
    • Organizer
      第41回神経組織培養研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22599
  • [Presentation] 定量プロテオミクスによるヒト血液脊髄関門における膜タンパク質の定量的発現プロファイルの解明2019

    • Author(s)
      八木悠太, 内田康雄, 梅津美奈, 平野誠巳, 立川正憲, 田野光敏, 高尾昌樹, 寺崎哲也
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開2018

    • Author(s)
      立川正憲
    • Organizer
      第24回創剤フォーラム若手研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] 多発性硬化症における中枢関門の破綻への新規密着結合分子claudin-11 の寄与の解明2018

    • Author(s)
      内田康雄, 住谷智仁, 立川正憲, 山川達也, 村田将, 八木悠太, 佐藤和貴, 伊藤克彰, 大槻純男, Pierre-Olivier Couraud, 鈴木貴, 寺崎哲也
    • Organizer
      日本薬剤学会第33 年会
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] Pressure Cycling Technologyを用いたホルマリン固定パラフィン包埋切片プロテオミクス定量系の薬物関連タンパク質への応用2018

    • Author(s)
      佐々木颯, 内田康雄, 立川正憲, 寺崎哲也
    • Organizer
      第40回 生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] ラット血液脊髄関門と血液脳関門におけるトランスポータータンパク質発現量の類似性と相違性の解明2018

    • Author(s)
      八木悠太、内田康雄、立川正憲、寺崎 哲也
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Sulfo-SBED/SWATHプロテオミクスを用いたヒト血液脳関門モデルhCMEC/D3細胞におけるエクソソーム受容体の同定2018

    • Author(s)
      黒田広樹, 立川正憲, 八木悠太, 内田康雄, 寺崎哲也
    • Organizer
      第40回 生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 網羅的定量プロテオミクスと薬動力学に基づくプラズマ生体作用の分子的解明2018

    • Author(s)
      立川正憲
    • Organizer
      第40回日本光医学・光生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] 中枢関門の密着結合形成におけるclaudin-11の寄与と多発性硬化症におけるその発現低下の解明2018

    • Author(s)
      住谷智仁、内田康雄、山川達也、村田将、八木悠太、佐藤和貴、伊藤克彰、立川正憲、大槻純男、鈴木貴、寺崎哲也
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] ブタ脈絡叢と脳軟髄膜の網羅的・標的プロテオミクス解析:OATP1A2、OCT2及びMATE1の発現局在とCSF中薬物動態における役割2018

    • Author(s)
      後藤諒平、内田康雄、立川正憲、平野誠巳、張正宇、寺崎哲也
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Usefulness of Pressure Cycling Technology-assisted sample process for accurate and comprehensive quantitative proteomics using FFPE section; application for ADME-related proteins2018

    • Author(s)
      Sasaki H, Uchida Y, Tachikawa M, Terasaki T
    • Organizer
      第33回日本薬物動態学会・MDO国際合同年会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Quantitative targeted and global proteomics analysis of brain microvessels in pharmacoresistant epilepsy2018

    • Author(s)
      Omori K, Grant G, Tachikawa M, Porter B, Bet A, Uchida Y, Terasaki T
    • Organizer
      2018 Gordon Research Conference on Barriers of the CNS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 血液クモ膜関門を介した脳脊髄液中α-synuclein排出輸送機構の解明2018

    • Author(s)
      矢口優佳、立川正憲、内田康雄、寺崎哲也
    • Organizer
      第40回 生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 中枢薬剤学-Connecting the dots2018

    • Author(s)
      立川正憲
    • Organizer
      日本薬剤学会第32年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15153
  • [Presentation] SWATH及び高精度ペプチド選択を組み合わせた膜タンパク質のApical/Basolateral膜局在と絶対発現量の網羅的推定法の開発2018

    • Author(s)
      平野誠巳、内田康雄、立川正憲、後藤諒平、寺崎哲也
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 血液クモ膜関門を介した脳脊髄液中α-synuclein排出輸送機構の解明2018

    • Author(s)
      矢口優佳、立川正憲、内田康雄、寺崎哲也
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] Sulfo-SBED/SWATH proteomics-based identification of RGD receptor integrins as the receptors for SK-Mel-28-derived exosomes internalization into human blood-brain barrier hCMEC/D3 cells2018

    • Author(s)
      Kuroda H, Tachikawa M, Uchida Y, Terasaki T
    • Organizer
      2018 Gordon Research Conference on Barriers of the CNS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Identification and absolute quantification of Transporters in the isolated human brain microvessels by next-generation quantitative proteomics SWATH-MS2018

    • Author(s)
      Umetsu M, Uchida Y, Hirano S, Takao M, Tachikawa M, Terasaki T
    • Organizer
      第33回日本薬物動態学会・MDO国際合同年会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Proteomics based characterization of the blood-spinal cord barrier transporters in rats: Comparison with the blood-brain barrier2017

    • Author(s)
      八木悠太、立川正憲、内田康雄、寺崎哲也
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] クレアチン脳欠乏症治療を指向したカチオン性アミノ酸トランスポーターを輸送経路とするクレアチンプロドラッグの開発2017

    • Author(s)
      太田悠介、立川正憲、吉田将人、土井隆行、和田敬仁、寺崎 哲也
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-27
    • Data Source
      KAKENHI-PROJECT-16K15153
  • [Presentation] 脳脊髄液中薬物動態における血液クモ膜関門の役割: 有機アニオン排出経路としてのoatp1a4の輸送機能と発現の証明2017

    • Author(s)
      矢口優佳、立川正憲、張正宇、内田康雄、寺崎哲也
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-26
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] OUTER blood-CSF barrier (arachnoid membrane) abundantly expresses OAT1, OAT3, PEPT2 and BCRP proteins as compared to INNER blood-CSF barrier (choroid plexus)2017

    • Author(s)
      後藤諒平、内田康雄、立川正憲、平野誠巳、張正宇、寺崎哲也
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] Development of label free comprehensive absolute quantification method by SWATH-MS combined with in silico peptide selection criteria ~Its application for the hepatic drug delivery~2017

    • Author(s)
      平野誠巳、内田康雄、立川正憲、後藤諒平、寺崎哲也
    • Organizer
      日本薬物動態学会第32回年会(優秀口頭発表賞受賞)
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] 中枢関門におけるandrogen刺激に応答したclaudin-11発現調節作用の解明と血液クモ膜関門におけるclaudin-11の発現解析2017

    • Author(s)
      住谷智仁、内田康雄、 山川達也、村田将、張正宇、立川正憲、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] Development of label free comprehensive absolute quantification method by SWATH-MS combined with in silico peptide selection criteria : Its application for the hepatic drug delivery2017

    • Author(s)
      平野誠巳、内田康雄、立川正憲、後藤諒平、寺崎哲也
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 血液脳関門機能の可塑的変化と脳血管-グリア連関2017

    • Author(s)
      立川正憲
    • Organizer
      千里ライフサイエンスセミナーL3神経変性疾患の最前線(グリア細胞と神経疾患)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01326
  • [Presentation] ブタBRB, BBB及びBCSFBの輸送担体の絶対発現量解析:BCRPの重要性2017

    • Author(s)
      張正宇、内田康雄、平野誠巳、安藤大介、久保義行、 Seppo Auriola、赤沼伸乙、立川正憲、細谷健一、Arto Urtti、寺崎哲也
    • Organizer
      日本薬剤学会第32年会 (最優秀発表賞受賞)
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] 中枢薬剤学-Connecting the dots2017

    • Author(s)
      立川正憲
    • Organizer
      日本薬剤学会第32年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01326
  • [Presentation] Oat1/3 and Oatp1a4 are acting as avid elimination pathway of organic anion in the CSF at the blood-arachnoid barrier (BAB)2017

    • Author(s)
      Tachikawa M, Yaguchi Y, Zhang Z, Uchida Y, Terasaki T.
    • Organizer
      12th INTERNATIONAL CONFERENCE on CEREBRAL VASCULAR BIOLOGY 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] Proteomics based characterization of the blood-spinal cord barrier transporters in rats: Comparison with the blood-brain barrier2017

    • Author(s)
      八木悠太、立川正憲、内田康雄、寺崎哲也
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 標的定量質量分析法に基づくクモ膜上皮細胞と脈絡叢上皮細胞の有機アニオントランスポータータンパク質の解析:脳脊髄液中薬物動態における役割評価2017

    • Author(s)
      張正宇、立川正憲、内田康雄、寺崎哲也
    • Organizer
      第39回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] 脳転移性メラノーマ細胞由来exosomesによるヒト脳毛細血管内皮細胞株hCMEC/D3のエネルギー代謝抑制制御2017

    • Author(s)
      TRAN Quynh-Phuong、内田康雄、黒田広樹、梅津美奈、八木悠太、立川正憲、寺崎哲也
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-16K15475
  • [Presentation] 有機アニオン性物質プロスタグランジンD2及びsulforhodamine-101の脳脊髄液クリアランス経路としてのラット血液クモ膜関門Oatp1a4の機能的役割2017

    • Author(s)
      矢口優佳、立川正憲、張正宇、内田康雄、寺崎哲也
    • Organizer
      第11回次世代を担う若手医療薬科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] 標的定量質量分析法に基づくクモ膜上皮細胞と脈絡叢上皮細胞の有機アニオントランスポータータンパク質の解析:脳脊髄液中薬物動態における役割評価2017

    • Author(s)
      張正宇、立川正憲、内田康雄、寺崎哲也
    • Organizer
      第39回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04004
  • [Presentation] 脳脊髄液中薬物動態における血液クモ膜関門の役割:有機アニオン排出経路としてのoat1, oat3の輸送機能と発現の証明2017

    • Author(s)
      張正宇、立川正憲、内田康雄、矢口優佳、寺崎 哲也
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-26
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] アラクノイドバリアーにおける有機アニオン輸送体の発現と外側血液脳脊髄液関門としての機能的役割2016

    • Author(s)
      立川正憲
    • Organizer
      日本薬物動態学会第31回年会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Year and Date
      2016-10-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08364
  • [Presentation] Abl及びSrc kinasesによる血液脳関門P-glycoproteinの細胞内トラフィッキング制御機構の解明2016

    • Author(s)
      星 裕太朗、内田 康雄、立川 正憲、大槻 純男、寺崎 哲也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Application of Advanced Quantitative Proteomics to the human blood-brain barrier research.2016

    • Author(s)
      Tachikawa M.
    • Organizer
      Japanese-German YoungGlia collaborative meeting for mutual research exchange
    • Place of Presentation
      Center for Integrative Physiology and Molecular Medicine, University of Saarland (Homburg, Germany)
    • Year and Date
      2016-05-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01326
  • [Presentation] 定量プロテオミクス解析から見えてきた血液脳関門輸送機能の可塑的変化2016

    • Author(s)
      立川正憲
    • Organizer
      第3回 新学術領域研究「グリアアセンブリ」若手の会
    • Place of Presentation
      蔵王アストリアホテル(山形県山形市)
    • Year and Date
      2016-07-14
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01326
  • [Presentation] 発達初期低タンパク質栄養は成熟期の血液脳関門輸送体発現を変化させる2016

    • Author(s)
      最上侑佑盛、中畑亜加音、佐藤和貴、立川正憲、古屋茂樹
    • Organizer
      日本アミノ酸学会10周年記念大会
    • Place of Presentation
      東京大学伊藤国際学術研究センター
    • Data Source
      KAKENHI-PROJECT-26292071
  • [Presentation] グアニジノ化合物の脳内動態と神経疾患2015

    • Author(s)
      立川正憲
    • Organizer
      第36回部兄時の化合物研究会
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2015-08-08
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Pathological impact of hemichannels-mediated gateway on the brain barrier transport dynamics.2015

    • Author(s)
      Tachikawa T.
    • Organizer
      Pharmaceutical Science Symposium 2015
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-11-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターの発現・局在と輸送機能特性の解析2015

    • Author(s)
      上村立記、伊藤慎悟、太田悠介、立川正憲、平山未央、和田 敬仁、寺崎哲也、大槻純男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] 標的プロテオミクスに基づくタンパク質リン酸化修飾の定量的解析2015

    • Author(s)
      星裕太朗、内田康雄、立川正憲、大槻純男、寺崎哲也
    • Organizer
      日本プロテオーム学会2015年会
    • Place of Presentation
      熊本
    • Year and Date
      2015-07-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Impact of pannexin 1 and connexin 43 hemichannels on extracellular calcium-dependent transport dynamics in human brain capillary endothelial cells.2015

    • Author(s)
      Tachikawa M, Kaneko Y, Akaogi R, Uchida Y, Couraud PO, Terasaki T.
    • Organizer
      Barcelona BioMed Conference, Blood Brain Barrier
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-11-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Presentation] Post-translational regulation of P-glycoprotein function at the blood-brain barrier involved in caveolin-1 tyrosine 14 phosphorylation.2015

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.
    • Organizer
      30th JSSX Annual Meeting
    • Place of Presentation
      東京
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Molecular genetic study and urine analysis of Japanese patients with cerebral creatine deficiency syndromes.2015

    • Author(s)
      H. Shimbo, H. Osaka, M. Tachikawa, S. Ohtsuki, S. Ito, T. Goto, Y. Tsuyusaki, N. Aida, K. Kurosawa, Y. Kurosawa, H. Kato, K. Takano, T. Wada.
    • Organizer
      65th American Society&#160;of&#160;Human Genetics
    • Place of Presentation
      Baltimore
    • Year and Date
      2015-10-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Changes of cellular localization and transport activity by a novel mutation in creatine transporter associated with chronic cerebral creatine depletion2015

    • Author(s)
      Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
    • Organizer
      International Symposium on Chronic Inflammatory Diseases
    • Place of Presentation
      Kumamoto
    • Year and Date
      2015-10-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Global and Quantitative Targeted Phosphoproteomic Studies on the Blood-Brain Barrier P-gp Regulation Mechanism in Acute Phase Diseased Models.2015

    • Author(s)
      Hoshi Y, Uchida Y, Kuroda T, Tachikawa T, Terasaki T
    • Organizer
      BioMed Conference, Blood Brain Barrier
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-11-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 血液脳関門ファーマコプロテオミクスに立脚した中枢疾患創薬の提言2015

    • Author(s)
      立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] リン酸化定量プロテオミクスに基づく血液脳関門P-glycoproteinの輸送活性制御機構の解明2015

    • Author(s)
      星裕太朗、内田康雄、立川正憲、大槻純男、寺崎哲也
    • Organizer
      第10回トランスポーター研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-20
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 「脳クレアチン欠乏症候群の臨床研究班」の取り組み2015

    • Author(s)
      和田敬仁,小坂仁,相田典子,後藤知英,露崎悠,新保裕子,加藤秀一,高野亨子,大槻純男,伊藤慎悟,立川正憲,黒澤裕子
    • Organizer
      第57回日本小児神経学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-27
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] 新規変異クレアチントランスポーターの機能と発現解析2015

    • Author(s)
      上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki: Changes in transport activity and cellular localization by a novel missense mutation in human creatine transporter found in Japanese cerebral creatine deficiency syndromes patients2015

    • Author(s)
      Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
    • Organizer
      Barcelona BioMed Conference Blood Braine Barrier
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] 血液脳関門ファーマコプロテオミクスに立脚した中枢疾患創薬の提言2015

    • Author(s)
      立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Presentation] 前処理自動化と質量分析を組み合わせたハイスループットMRM法の開発2014

    • Author(s)
      米山敏広、大槻純男、尾野雅哉、大峰健、内田康雄、立川正憲、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] 標的定量プロテオミクス解析に基づく病態時血液脳関門輸送系の可塑的変化の解明2014

    • Author(s)
      立川正憲、星裕太朗、佐藤和貴、内田康雄、大槻純男、寺崎哲也
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-31
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 生体膜薬物輸送研究におけるタンパク質絶対定量情報の活用2014

    • Author(s)
      立川正憲
    • Organizer
      第22回クリニカルファーマシーシンポジウム 医療薬学フォーラム2014
    • Place of Presentation
      東京
    • Year and Date
      2014-06-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Plasticity and robustness of the blood-brain-barrier transporters, channels, and receptors: a study of advanced quantitative targeted proteomics.2014

    • Author(s)
      Tachikawa M
    • Organizer
      19th North American ISSX/29th JSSX Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-10-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Presentation] マウス炎症性疾患モデルを用いた脳毛細血管における接着分子の標的定量プロテオミクス解析2014

    • Author(s)
      佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      第22回クリニカルファーマシーシンポジウム 医療薬学フォーラム2014
    • Place of Presentation
      東京
    • Year and Date
      2014-06-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 標的定量プロテオミクスを活用したクレアチントランスポーター輸送活性評価法の構築2014

    • Author(s)
      太田悠介、立川正憲、落合祐介、寺崎哲也
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Plasticity and robustness of the blood-brain-barrier transporters, channels, and receptors: a study of advanced quantitative targeted proteomics.2014

    • Author(s)
      Tachikawa M
    • Organizer
      19th North American ISSX/29th JSSX Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-10-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Pharmacological impact of the brain barrier prostaglandin transport2014

    • Author(s)
      Tachikawa M
    • Organizer
      20th Annual Blood-Brain Barrier Consortium Meeting
    • Place of Presentation
      Sunriver, USA
    • Year and Date
      2014-03-21
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 開口スイッチの導入によるpannexin1及びconnexin32機能解析系の構築と輸送特性の解明2014

    • Author(s)
      赤荻諒、立川正憲、金子洋介、内田康雄、寺崎哲也
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性2014

    • Author(s)
      立川正憲, 金子洋介, 赤荻諒, 内田康雄, 大槻純男, 寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-30
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 標的絶対定量プロテオミクスに基づくがん分子標的化学療法の個別・層別化基盤の構築2014

    • Author(s)
      内田康雄、立川正憲、小渕航、大槻純男、中田光俊、濱田潤一郎、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] 血液脳関門—白血球細胞遊走に関わる接着分子の標的定量プロテオミクス解析2014

    • Author(s)
      佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] タンパク質絶対定量情報を活用したクレアチントランスポーター輸送活性予測法の構築2014

    • Author(s)
      立川正憲
    • Organizer
      第35回グアニジノ化合物研究会
    • Place of Presentation
      筑波
    • Year and Date
      2014-10-11
    • Data Source
      KAKENHI-PROJECT-26461544
  • [Presentation] Channels at the Barriers: A Non-Transporter-Mediated Gateway.2014

    • Author(s)
      Tachikawa M
    • Organizer
      Gordon Research Conference, Barriers of the CNS
    • Place of Presentation
      New London, USA
    • Year and Date
      2014-06-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Presentation] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2013-09-30
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能2013

    • Author(s)
      立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-25
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 仮想selective reaction monitoring法を用いた白血球細胞膜上タンパク質の高感度標的プロテオミクス2013

    • Author(s)
      佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport: An application of quantitative targeted proteomics2013

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      10th international conference on Cerebral Vascular Biology
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Quantitative targeted absolute proteomics of the malignant brain tumors towards molecular-targeted chemotherapy.2013

    • Author(s)
      Terasaki T., Obuchi W., Ohtsuki S.,Nakada M., Uchida Y., Tachikawa M., Hamada J.
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Toronto, Canada
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] 膜タンパク質を標的とした定量的標的プロテオミクスに基づく悪性脳腫瘍に対する個別化分子標的療法2013

    • Author(s)
      小渕航、大槻純男、中田光俊、内田康雄、立川正憲、濱田潤一郎、寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-23
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築2013

    • Author(s)
      立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 膵癌細胞のゲムシタビン感受性増強を目的とした併用薬のスクリーニング2013

    • Author(s)
      黒田広樹、立川正憲、内田康雄、寺崎哲也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] Quantitative targeted absolute proteomics of the malignant brain tumors towards molecular-targeted chemotherapy2013

    • Author(s)
      Terasaki T, Obuchi W, Ohtsuki S, Nakada M, Uchida Y, Tachikawa M, Hamada J
    • Organizer
      10th International Society for the Study of Xenobiotics (ISSX) Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2013-09-30
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport.2013

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Toronto, Canada
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport : An application of quantitative targeted proteomics2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      10th international conference on Cerebral Vascular Biology
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 血液脳関門輸送機能変動因子としてのヘミチャネル2013

    • Author(s)
      立川正憲
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-11-22
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      International Gap Junction Conference 2013
    • Place of Presentation
      Charleston, USA
    • Year and Date
      2013-07-16
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents2012

    • Author(s)
      立川正憲, 村上晃路, 赤沼伸乙, 細谷健一
    • Organizer
      第2回新潟大学脳研究所共同研究拠点国際シンポジウム
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells2012

    • Author(s)
      金子洋介、立川正憲, 他
    • Organizer
      BRI International Symposium 2012
    • Place of Presentation
      新潟
    • Year and Date
      2012-03-03
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Profile of hemichannls mRNA expresson at the blood-brain and inner blood-retinal barriers in mice2012

    • Author(s)
      Akanuma S, Murakami K, Tachikawa M, Kubo Y, Hosoya K
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Year and Date
      2012-11-20
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Pathophysiological impact of hemichannels on the blood-brain barrier transport.2012

    • Author(s)
      Tachikawa M
    • Organizer
      15th International Symposium Signal Transduction in the Blood-Brain Barriers
    • Place of Presentation
      Potsdam-Sanssouci, Germany
    • Invited
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] ヘミチャネルファミリーを標的とした定量プロテオミクス2012

    • Author(s)
      立川正憲, 金子洋介, 内田康雄, 寺崎哲也
    • Organizer
      日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Year and Date
      2012-10-07
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 脳及び網膜毛細血管皮細胞におけるヘミチャネル分子のmRNA発現解析2012

    • Author(s)
      村上晃路、立川正憲, 他
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Targeted quantitative LC-MS/MS methods of bevacizumab, a therapeutic monoclonal antibody2012

    • Author(s)
      Ebata Y, Ohtsuki S, Tachikawa M, Uchida Y, Terasaki T
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Year and Date
      2012-11-21
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation2012

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology : Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2012-09-07
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] 脳及び網膜毛細血管内皮細胞におけるヘミチャネル分子のmRNA 発現解析2012

    • Author(s)
      村上晃路, 立川正憲, 赤沼伸乙, 久保義行, 細谷健一
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells2012

    • Author(s)
      金子洋介, 立川正憲, 寺崎哲也
    • Organizer
      第2回新潟大学脳研究所共同研究拠点国際シンポジウム
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier2012

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Ohtsuki S, Couraud PO, Terasaki T
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Year and Date
      2012-11-20
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Pathophysiological impact of hemichannels on the blood-brain barrier transport2012

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      Fifteenth International Symposium Signal Transduction in the Blood-Brain Barriers
    • Place of Presentation
      Potsdam-Sanssouci, Germany
    • Year and Date
      2012-09-15
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation2012

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology : Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2012-09-07
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents2012

    • Author(s)
      立川正憲、村上晃路, 他
    • Organizer
      BRI International Symposium 2012
    • Place of Presentation
      新潟
    • Year and Date
      2012-03-03
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 脳脊髄液からのL-glutamate排出輸送解析2011

    • Author(s)
      櫻井達彦、赤沼伸乙、立川正憲、久保義行、細谷健一
    • Organizer
      日本薬学会北陸支部第123回例会
    • Place of Presentation
      金沢市
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Role of organic anion transporter 3 at the blood-cerebrospinal fluid barrier in the elimination of prostaglandin E_2 produced in the brain2011

    • Author(s)
      Akanuma S., Ozeki G., Tachikawa M., Hosoya K.
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島県広島市
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] グアニジノ化合物のトランスポーターと脳関門輸送2011

    • Author(s)
      立川正憲
    • Organizer
      第32回グアニジノ化合物研究会
    • Place of Presentation
      酒田(招待講演)
    • Year and Date
      2011-10-29
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Role of organic anion transporter 3 at the blood-cerebrospinal fluid barrier in the elimination of prostaglandin E_2 produced in the brain2011

    • Author(s)
      Shin-ichi Akanuma, Gou Ozeki, Masanori Tachikawa, Ken-ichi Hosoya
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島市
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] グアニジノ化合物のトランスポーターと脳関門輸送2011

    • Author(s)
      立川正憲
    • Organizer
      第32回グア ニジノ化合物研究会
    • Place of Presentation
      酒田
    • Year and Date
      2011-10-29
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 脳脊髄液からのL-glutamate排出輸送解析2011

    • Author(s)
      櫻井達彦、赤沼伸乙、立川正憲、久保義行、細谷健一
    • Organizer
      日本薬学会北陸支部第123回例会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割2010

    • Author(s)
      立川正憲
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2010-11-30
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE2排出の阻害2010

    • Author(s)
      赤沼伸乙、伊藤慎悟、立川正憲、大槻純男、細谷健一、寺崎哲也
    • Organizer
      日本薬学会 第130年会(会期 平成22年3月28日-30日)
    • Place of Presentation
      岡山桃太郎アリーナ
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE_2排出の阻害2010

    • Author(s)
      赤沼伸乙、伊藤慎悟、立川正憲、大槻純男、細谷健一、寺崎哲也
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山県岡山市
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割2010

    • Author(s)
      立川正憲, 細谷健一
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2010-11-30
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Effect of lipophilicity and carrier-mediated transport on blood-retinal barrier permeability2010

    • Author(s)
      Hosoya K., Yamamoto A., Akanuma S., Tachikawa M.
    • Organizer
      FIP pharmaceutical sciences 2010 world congress/AAPS annual meeting and exposition.
    • Place of Presentation
      Neu Orileans, USA
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Organic anion transporter3を介したprostaglandin E_2輸送機能解析2010

    • Author(s)
      樋口貴則、赤沼伸乙、立川正憲、細谷健一
    • Organizer
      日本薬学会北陸支部平成22年度第1回総会及び第122回例会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2010-11-21
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] 血液脳脊髄液関門を介したprostaglandin E_2排出におけるorganic anion transporter(OAT) 3の関与2010

    • Author(s)
      小関剛、赤沼伸乙、立川正憲、細谷健一
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山県富山市
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Involvement of Prostaglandin Transporter in Prostaglandin D2 Transport at the Blood-cerebrospinal Fluid Barrier2009

    • Author(s)
      Kazuhiro Tsuji, Masanori Tachikawa, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura, Ken-ichi Hosoya
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angeles Convention Center
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] 脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析2009

    • Author(s)
      小関剛、辻和宏、赤沼伸乙、立川正憲、細谷健一
    • Organizer
      日本薬学会北陸支部第121回例会
    • Place of Presentation
      富山大学杉谷(医薬系)キャンパス
    • Year and Date
      2009-12-06
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] 脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析2009

    • Author(s)
      小関剛、辻和宏、赤沼伸乙、立川正憲、細谷健一
    • Organizer
      日本薬学会北陸支部第121回例会
    • Place of Presentation
      富山県富山市
    • Year and Date
      2009-12-06
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Localization and transport function of prostaglandin transporter (PGT) in the brain2009

    • Author(s)
      Kazuhiro Tsuji, Masanori Tachikawa, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura, Ken-ichi Hosoya
    • Organizer
      8^<th> Cerebral Vascular Biology 2009
    • Place of Presentation
      仙台エクセルホテル東急
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Involvement of Prostaglandin Transporter in Prostaglandin D_2 Transport at the Blood-cerebrospinal Fluid Barrier2009

    • Author(s)
      Tsuji K., Tachikawa M., Akanuma S., Hayashi K., Nishiura A., Hosoya K.
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angeles, USA
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Localization and transport function of prostaglandin transporter(PGT) in the brain2009

    • Author(s)
      Tsuji K., Tachikawa M., Akanuma S., Hayashi K., Nishiura A., Hosoya K.
    • Organizer
      8^<th> Cerebral Vascular Biology 2009
    • Place of Presentation
      宮城県仙台市
    • Data Source
      KAKENHI-PROJECT-21390042
  • [Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier.2007

    • Author(s)
      M. Tachikawa
    • Organizer
      4th World Conference on Drug Absorption, Transport and Delivery
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Presentation] Involvement of transporters in the retina-to-blood efflux transport of organic anions at the inner blood-retinal barrier2007

    • Author(s)
      K, Hosoya, A. Makihara, Y, Ohshima, K, Katayama, M, Tomi, M, Tachikawa
    • Organizer
      29th Symposium on Biomembrane-Drug Interaction
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Presentation] The role of scavenger receptor class B type I(SR-BI) in vitamin E uptake at the inner blood-retinal barrier2007

    • Author(s)
      S, Okayasu, M, Tachikawa, K, Hosoya
    • Organizer
      AAPS annual meeting and exposition
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Presentation] Creatine transporter functions as guanidinoacetate transporter at the blood-cerebrospinal fluid barrier.2007

    • Author(s)
      Tachikawa M.
    • Organizer
      3rd Pharmaceutical Science World Congress
    • Place of Presentation
      Amsterdam
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier2007

    • Author(s)
      M, Tachikawa, M, Toki, M, Tomi, K, Hosoya
    • Organizer
      4th World Conference on Drug Absorption, Transport and Delivery
    • Place of Presentation
      Kanazawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Presentation] The role of reduced folate transporter1(RTF1) in methyletrahydrofolate transport at the inner blood-retinal barrier2007

    • Author(s)
      K, Fujita, M, Tachikawa, K, Hosoya
    • Organizer
      AAPS annual meeting and exposition
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390048
  • [Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier.2007

    • Author(s)
      Tachikawa M.
    • Organizer
      4th World Conference on Drug Absorption, Transport and Delivery
    • Place of Presentation
      Kanazawa
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Presentation] Creatine transporter (CRT/SLC6A8) acting as a guanidino compound transpoter at the blood-cerebrospinal fluid barrier.2007

    • Author(s)
      Tachikawa M.
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Presentation] A new function of creatine transporter (CRT/SLC6A8) acting as a guanidino compound transporter at the blood-cerebrospinal fluid barrier.2007

    • Author(s)
      Tachikawa M.
    • Organizer
      37th Annual Meeting Society for Neuroscience
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-18790115
  • [Presentation] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築

    • Author(s)
      立川正憲
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] ヒト血液脳脊髄液関門におけるトランスポータータンパク質発現量及びラットとの種差の解明

    • Author(s)
      張正宇、内田康雄、立川正憲、寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 標的絶対定量プロテオミクスに基づくがん分子標的化学療法の個別・層別化基盤の構築

    • Author(s)
      内田康雄、立川正憲、小渕航、大槻純男、中田光俊、濱田潤一郎、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] Dynamic plasticity of “Cluster of differentiation antigen” expressions at the inflammatory blood-brain barrier.

    • Author(s)
      Sato K, Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Organizer
      19th North American ISSX/29th JSSX Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-25670067
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology: Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Phosphorylation of actin filament-associated protein as a regulatory mechanism of intrinsic P-glycoprotein transport activity in human brain capillary endothelial cells: A study of LC-MS/MS based-comprehensive and comparative phospho-proteomics.

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Terasaki T
    • Organizer
      19th North American ISSX/29th JSSX Meeting,
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能

    • Author(s)
      立川正憲、金子洋介、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 膜タンパク質を標的とした定量的標的プロテオミクスに基づく悪性脳腫瘍に対する個別化分子標的療法

    • Author(s)
      小渕航、大槻 純男、中田 光俊、内田 康雄、立川 正憲、濱田 潤一郎、寺崎 哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] 血液脳関門輸送機能変動因子としてのヘミチャネル

    • Author(s)
      立川正憲
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京都文京区
    • Invited
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology: Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659063
  • [Presentation] Phosphoproteomic approach to clarify regulatory mechanism for intrinsic transport function of one P-glycoprotein molecule at blood-brain barrier: Involvement of tyrosine 14 phosphorylation in caveolin-1.

    • Author(s)
      Hoshi Y., Uchida Y., Tachikawa M., Ohstuki S., Terasaki T.
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京都江戸川区
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Pharmacological impact of the brain barrier prostaglandin transport.

    • Author(s)
      Tachikawa M.
    • Organizer
      20th Annual Blood-Brain Barrier meeting
    • Place of Presentation
      Sunriver, Oregon, United States
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Quantitative proteomics-based investigation of regulatory mechanism for P-glycoprotein efflux activity at the blood-brain barrier in central nervous system disease: epilepsy and inflammation.

    • Author(s)
      Uchida Y., Hoshi Y., Tachikawa M., Ohtsuki S., Terasaki T.
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京都江戸川区
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Transport characteristics of exosomes in human brain capillary endothelial cells.

    • Author(s)
      Kuroda H, Tachikawa M, Uchida Y, Terasaki T
    • Organizer
      19th North American ISSX/29th JSSX Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier.

    • Author(s)
      Tachikawa M
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      International Gap Junction Conference 2013
    • Place of Presentation
      Charleston, South Carolina, United States
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Pharmacological impact of the brain barrier prostaglandin transport

    • Author(s)
      Tachikawa M.
    • Organizer
      20th Annual Blood-Brain Barrier Consortium Meeting
    • Place of Presentation
      Sunriver, Oregon, United States
    • Invited
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性

    • Author(s)
      立川正憲、金子洋介、赤荻諒、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Invited
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Involvement of caveolin-1 tyrosine 14 and src tyrosine 419 phosphorylation levels in intrinsic P-glycoprotein transport function at human blood-brain barrier.

    • Author(s)
      Hoshi Y,Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Organizer
      5th FIP Pharmaceutical Sciences World Congress
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-04-13 – 2014-04-16
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] Species difference in transporter protein expression levels at the blood-cerebrospinal fluid barrier between human and rat.

    • Author(s)
      Cho S., Uchida Y., Tachikawa M., Terasaki T.
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京都江戸川区
    • Data Source
      KAKENHI-PROJECT-24249011
  • [Presentation] ヘミチャネルファミリーを標的とした定量プロテオミクス

    • Author(s)
      立川正憲
    • Organizer
      日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Data Source
      KAKENHI-PROJECT-22689005
  • [Presentation] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier.

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京都江戸川区
    • Data Source
      KAKENHI-PROJECT-22689005
  • 1.  HOSOYA Ken-ichi (70301033)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 33 results
  • 2.  Terasaki Tetsuya (60155463)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 66 results
  • 3.  Funamoto Kenichi (70451630)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 4.  UCHIDA Yasuo (70583590)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 73 results
  • 5.  AKANUMA Shin-ichi (30467089)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KIRA Junichi (40183305)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  SAKAI Hideki (60242509)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  NAKADA Mitsutoshi (20334774)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 9.  MOTOI Fuyuhiko (30343057)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  OHTSUKA Hideo (50451563)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  KUBO Yoshiyuki (20377427)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 12.  Kanemaru Kazunori (10456105)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  IINO Masamitsu (50133939)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  TANAKA Kenji (30329700)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  福田 達也 (90805160)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  WATANABE Michitoshi (40303127)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HAMADA Junichiro (40253752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  FURUYA Shigeki (00222274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  WADA Takahito (70359727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 20.  OHTSUKI Sumio (60323036)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 21.  HATANAKA Yasumaru (30111181)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MIZUGUCHI Mineyuki (30332662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  OKUBO Yohei (40422282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SEKIYA Hiroshi (40511374)
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  • 25.  Mizuma Masamichi (80578675)
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  • 26.  IKENAKA Kazuhiro (00144527)
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  • 27.  ITO Kei (00311192)
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  • 34.  YAMAZAKI Yoshihiko (10361247)
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  • 37.  OZAKI Norio (40281480)
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  • 38.  KANBA Shigenobu (50195187)
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  • 39.  KOHSAKA Shinichi (50112686)
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  • 40.  FUKUYAMA Hidenao (90181297)
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  • 41.  BANNAI Hiroko (40332340)
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  • 42.  NAKASHIMA Kinichi (80302892)
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  • 43.  IMAI Hiroo (60314176)
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  • 44.  MATSUI Ko (20435530)
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  • 45.  KAKEGAWA Wataru (70383718)
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  • 46.  KANEKO Toshiro (30312599)
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  • 47.  大熊 芳明 (70192515)
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  • 48.  伊藤 慎悟 (20466535)
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  • 50.  小坂 仁 (90426320)
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  • 61.  松瀬 大 (70596395)
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  • 62.  山崎 亮 (10467946)
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  • 63.  渡邉 充 (30748009)
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  • 64.  吉田 あつ子 (70793181)
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  • 65.  田丸 浩 (50324554)
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  • 66.  豊岡 尚樹 (10217565)
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  • 67.  新妻 邦泰 (10643330)
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  • 68.  KITAJIMA Nami
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  • 69.  TAKADATE Tatsuyuki
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  • 70.  ISEKI Masahiro
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  • 71.  HATA Tatsuo
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  • 72.  AOKI Shuichi
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  • 73.  SHIMURA Mitsuhiro
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  • 75.  SUZUKI Takashi
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  • 76.  IDE Soichiro
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  • 77.  赤沼 伸一
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    # of Collaborated Products: 21 results
  • 78.  目代 貴之
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