Ito Shingo 伊藤慎悟

… Alternative Names

ITO Shingo 伊藤慎悟

伊藤慎吾イトウシンゴ

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Researcher Number	20466535
Other IDs
Affiliation (Current)	2022: 熊本大学, 大学院生命科学研究部(薬), 准教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 熊本大学, 大学院生命科学研究部(薬), 准教授 2016: 熊本大学, 大学院生命科学研究部(薬), 助教 2014 – 2016: 熊本大学, その他の研究科, 助教 2015: 熊本大学, 大学院生命科学研究部, 助教 2014: 熊本大学, 大学院生命科学研究部(薬), 助教 … More 2012 – 2014: 熊本大学, 生命科学研究部, 助教 2013: 熊本大学, 大学院生命科学研究部, 助教 2008 – 2009: Tohoku University, 大学院・薬学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological Sciences / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Pediatrics / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator オーファントランスポーター / タンパク質翻訳後修飾 / 血液脳関門 / 腫瘍形成 / がん / プロテオミクス / 細胞増殖 / インスリン抵抗性 / 薬物動態学 / プロスタグランディンE2 … More / 薬物相互作用 / プロスタグランディン / NSAIDs / がん治療標的分子 / 細胞内代謝調節 / O-GlcNAc化修飾 / 定量的標的プロテオミクス / がん治療 / 肝臓がん / SWATH / 高インスリン血症 / トランスポーター / 細胞老化 / 定量プロテオーム解析 / 細胞浸潤 / p53 / O-グリコシル化 / 細胞膜透過ペプチド / 組織関門 / マクロピノサイトーシス / トランスサイトーシス / ドラックデリバリーシステム … More Except Principal Investigator 血液脳関門 / トランスポーター / 脳毛細血管 / 脳関門 / プロテオミクス / クレアチン / 輸送 / 内在化 / DDS / 脳毛細血管内皮細胞 / ABC transporter / 質量分析 / pharmacoproteomics / 標的絶対プロテオミクス / ファーマコプロテオミクス / MRP / 生理機能 / 磁気分離 / クレアチン欠乏症 / 細胞内局在 / 中枢疾患 / 中秋疾患 / 知的障害 / 先天性代謝異常 / 脳クレアチン欠乏症候群 / 治療薬 / クレアチントランスポーター / 発達障害 / iPS細胞 / グアニジノ化合物 / クレアチニン / グアニジノ酢酸 / 精神遅滞 / 自閉症 / 膜タンパク質 / 膜輸送 / 患者由来腫瘍同所移植モデル / 希少癌 Less

Identification of macrotranscytosis based on clarification of the molecular mechanism of transport of tissue barrier penetrating peptidesPrincipal Investigator
- Principal Investigator
  
  伊藤慎悟
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kumamoto University
New molecular mechanisms for membrane-mediated transcellular transport across the blood brain barrier
- Principal Investigator
  
  大槻純男
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kumamoto University
患者由来同所移植モデル（PDOX）を用いた希少癌に対する治療法の探索研究
- Principal Investigator
  
  川口桂
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Mcrotransport of the blood-brain barrier and its application to the permeable carrier.
- Principal Investigator
  
  OHTSUKI Sumio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kumamoto University
Regulation mechanism of cell senescence by orphan transporterPrincipal Investigator
- Principal Investigator
  
  ITO Shingo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
脳支援・防御機構としてのヒト脳関門におけるインスリン受容体機能の解明Principal Investigator
- Principal Investigator
  
  伊藤慎悟
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Mechanism of cellular localization of mutated creatine transporter toward therapy for creatine deficiency syndromes
- Principal Investigator
  
  Ohtsuki Sumio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes
- Principal Investigator
  
  WADA Takahito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
The pathological role of an orphan transporter in the regulation of cancer cell characteristicsPrincipal Investigator
- Principal Investigator
  
  ITO SHINGO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Identification of a novel cancer therapy target molecule by elucidating the physiological function of the orphan transporterPrincipal Investigator
- Principal Investigator
  
  ITO Shingo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Involvement of prostaglandin transport system at the blood-brainbarrier in the drug-induced vascular disorder in the brain.Principal Investigator
- Principal Investigator
  
  ITO Shingo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
PROTEOMICS-BASED ANALYSIS OF BLOOD-BRAIN BARRIER TRANSPORT SYSTEM
- Principal Investigator
  
  TERASAKI Tetsuya (TETSUYA Terasaki)
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University

All 2022 2021 2020 2019 2018 2017 2016 2015 2010 2008 Other

All Journal Article Presentation Patent

[Journal Article] Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood?Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells2021
- Author(s)
  Nagano Hinako、Ito Shingo、Masuda Takeshi、Ohtsuki Sumio
- Journal Title
  
  Pharmaceutical Research
  
  Volume: -
- DOI
  10.1007/s11095-021-03131-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-21H02649
[Journal Article] Advances in sample preparation for membrane proteome quantification2021
- Author(s)
  Masuda Takeshi、Ito Shingo、Ohtsuki Sumio
- Journal Title
  
  Drug Discovery Today: Technologies
  
  Volume: 39 Pages: 23-29
- DOI
  10.1016/j.ddtec.2021.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02649
[Journal Article] Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis2021
- Author(s)
  Ogata Seiryo、Ito Shingo、Masuda Takeshi、Ohtsuki Sumio
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 271678 Pages: 1026-1038
- DOI
  10.1177/0271678x20941449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02590, KAKENHI-PROJECT-19K05544
[Journal Article] Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers2021
- Author(s)
  Masuda Takeshi、Mori Ayano、Ito Shingo、Ohtsuki Sumio
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 36 Pages: 100361-100361
- DOI
  10.1016/j.dmpk.2020.09.006
- NAID
  210000165083
- ISSN
  1347-4367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-21H02649
[Journal Article] Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo2020
- Author(s)
  1.Shunsuke Yamaguchi, Shingo Ito, Takeshi Masuda, Pierre-Olivier Couraud, Sumio Ohtsuki
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 321 Pages: 744-755
- DOI
  10.1016/j.jconrel.2020.03.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J15384, KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-18H02590
[Journal Article] Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro2020
- Author(s)
  Ito Shingo、Oishi Mariko、Ogata Seiryo、Uemura Tatsuki、Couraud Pierre-Olivier、Masuda Takeshi、Ohtsuki Sumio
- Journal Title
  
  Pharmaceutics
  
  Volume: 12 Pages: 579-579
- DOI
  10.3390/pharmaceutics12060579
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-18H02590
[Journal Article] Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood?Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ2019
- Author(s)
  Masuda T, Hoshiyama T, Uemura T, Hirayama-Kurogi M, Ogata S, Furukawa A, Couraud PO, Furihata T, Ito S, Ohtsuki S
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 16 Pages: 2162-2171
- DOI
  10.1021/acs.molpharmaceut.9b00114
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02590, KAKENHI-PROJECT-19K05544
[Journal Article] Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet2019
- Author(s)
  Ogata S, Ito S, Masuda T, Ohtsuki S
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 36 Pages: 1-12
- DOI
  10.1007/s11095-019-2674-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02590, KAKENHI-PROJECT-19K05544
[Journal Article] Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells2019
- Author(s)
  Ito S, Honda G, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S
- Journal Title
  
  Pharmaceutical research
  
  Volume: 36 Pages: 39-39
- DOI
  10.1007/s11095-018-2565-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08373
[Journal Article] Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells.2018
- Author(s)
  Ito S, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S
- Journal Title
  
  Journal of pharmaceutical sciences
  
  Volume: 107 Pages: 3163-3170
- DOI
  10.1016/j.xphs.2018.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08373
[Journal Article] Abnormal <i>N</i>-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization2017
- Author(s)
  T. Uemura, S. Ito, Y. Ohta, M. Tachikawa, T. Wada, T. Terasaki, S. Ohtsuki
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 40 Issue: 1 Pages: 49-55
- DOI
  10.1248/bpb.b16-00582
- NAID
  130005188881
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293035, KAKENHI-PROJECT-26461544
[Journal Article] Regulation of tight-junction integrity by insulin in an in vitro model of human blood-brain barrier2017
- Author(s)
  Shingo Ito, Mari Yanai, Shunsuke Yamaguchi, Pierre-Olivier Couraud, Sumio Ohtsuki
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01562
[Journal Article] Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier2010
- Author(s)
  S. Ito, S. Ohtsuki, Y. Katsukura, M. Funaki, Y. Koitabashi, A. Sugino, S. Murata, T. Terasaki
- Journal Title
  
  J. Cereb. Blood Flow Metab.
  
  Volume: 31 Pages: 457-466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109002
[Journal Article] Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier2010
- Author(s)
  Ito S
- Journal Title
  
  J.Cereb.Blood Flow Metab.
  
  Volume: 31 Pages: 457-466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109002
[Journal Article] Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E_2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins2010
- Author(s)
  Shin-ichi Akanuma, Ken-ichi Hosoya, Shingo Ito, Masanori Tachikawa, Tetsuya Terasaki, Sumio Ohtsuki
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics (E-pub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790127
[Journal Article] Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins2010
- Author(s)
  Shin-ichi Akanuma, Ken-ichi Hosoya, Shingo Ito, Masanori Tachikawa, Tetsuya Terasaki, Sumio Ohtsuki
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790127
[Journal Article] Quantitative atlas of membrane transporter proteins : Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria2008
- Author(s)
  J. Kamiie, S. Ohtsuki, R. Iwase, K. Ohmine, Y. Katsukura, K. Yanai, Y. Sekine, Y. Uchida, S. Ito, T. Terasaki
- Journal Title
  
  Pharm. Res.
  
  Volume: 25 Pages: 1469-1483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109002
[Journal Article] Quantitative atlas of membrane transporter proteins : Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria2008
- Author(s)
  J. Kamiie, S. Ohtsuki, R. Iwase, K. Ohmine, Y. Katsukura, K. Yanai, Y. Sekine, Y. Uchida, S. Ito, T. Terasaki
- Journal Title
  
  Pharm. Res. 25
  
  Pages: 1469-1483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109002
[Patent] 血液脳関門透過性ペプチド2019
- Inventor(s)
  19.伊藤慎悟、大槻純男、山口駿介
- Industrial Property Rights Holder
  19.伊藤慎悟、大槻純男、山口駿介
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02590
[Patent] 血液脳関門透過性ペプチド2018
- Inventor(s)
  伊藤慎悟、大槻純男、山口駿介
- Industrial Property Rights Holder
  伊藤慎悟、大槻純男、山口駿介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-134042
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] Regulation of the blood-brain barrier by membrane receptor2022
- Author(s)
  Sumio Ohtsuki, Hinako Nagano, Seiryo Ogata, Takeshi Masuda, Shingo Ito
- Organizer
  4th Mini-Symposium on the Blood-Brain Barrier from Basic to Clinical Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02649
[Presentation] 定量プロテオミクスを基盤とする血液脳関門における物質輸送分子と病態発症機構の解明2022
- Author(s)
  伊藤慎悟
- Organizer
  日本薬学会第142年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02649
[Presentation] 細胞膜タンパク質ビオチン標識法とSWATH-MSによる網羅的タンパク質定量法を組み合わせたヒト脳毛細血管内皮細胞における細胞内内在化膜タンパク質の同定2021
- Author(s)
  伊藤慎悟、大石真梨子、緖方星陵、上村立記、Pierre-Olivier Couraud、増田豪、大槻純男
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02649
[Presentation] エチレングリコールを用いた細胞分画法とプロテオミクスへの応用2021
- Author(s)
  増田豪、伊藤慎悟、石濱泰、大槻純男
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02649
[Presentation] マウス大脳と小脳の単離毛細血管における血液脳関門プロテオーム比較解析2021
- Author(s)
  吉田尚功、伊藤慎悟、緒方星陵、増田豪、大槻純男
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21H02649
[Presentation] 環状ペプチドを用いた組織関門透過技術の開発2020
- Author(s)
  伊藤慎悟
- Organizer
  薬物動態談話会第43年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] Identification of cyclic peptide facilitating permeability of M13 phage across the blood-brain barrier,2019
- Author(s)
  Shunsuke Yamaguchi, Shingo Ito, Takeshi Masuda, Sumio Ohtsuki
- Organizer
  2019 Cerebral Vascular Biology Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] Identification of cell-surface proteins internalized into in vitro human brain microvascular endothelial cells by SWATH-based quantitative proteomics.2019
- Author(s)
  Shingo Ito, Mariko Oishi, Tatsuki Uemura, Takeshi Masuda, Tomomi Furihata, Pierre-Olivier Couraud, Sumio Ohtsuki
- Organizer
  BBB signaling 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] バイオ医薬品の脳内送達を目指した血液脳関門における高分子物質輸送機構の解明2019
- Author(s)
  伊藤慎悟
- Organizer
  NanoBio第12回若手ネットワーキングシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 高分子を脳実質へ送達する血液脳関門透過性環状ペプチドの同定2019
- Author(s)
  山口駿介、伊藤慎悟、増田豪、大槻純男
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 環状ペプチドを用いた組織関門透過技術の開発2019
- Author(s)
  伊藤慎悟
- Organizer
  第 32 回ケミカルバイオロジー研究所セミナー第 104 回生物科学フロンティアセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 生体関門輸送機能を基盤とした疾患メカニズムの解明と治療への展開2018
- Author(s)
  伊藤慎悟
- Organizer
  第5回分子薬剤学東北セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] Identification of internalized plasma membrane proteins in human brain capillary endothelial cells.2018
- Author(s)
  Mariko Oishi, Shingo Ito, Takeshi Masuda, Tomomi Furihata, Sumio Ohtsuki
- Organizer
  Mass Spec and Proteomics 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] Comprehensive identification of internalized membrane proteins in human brain capillary endothelial cells.2018
- Author(s)
  Mariko Oishi, Shingo Ito, Takeshi Masuda, Tomomi Furihata, Sumio Ohtsuki
- Organizer
  The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] Identification of novel internalized cell surface proteins in human brain capillary endothelial cells by SWATH-MS2018
- Author(s)
  Shingo Ito, Mariko Oishi, Takeshi Masuda, Tomomi Furihata, Sumio Ohtsuki
- Organizer
  SFN2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 高分子医薬品の脳内送達に資する血液脳関門透過性環状ペプチドの同定2018
- Author(s)
  山口駿介、伊藤慎悟、増田豪、大槻純男
- Organizer
  第1回超分子薬剤学FGシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 生体関門輸送機能を基盤とした疾患メカニズムの解明と治療への展開2018
- Author(s)
  伊藤慎悟
- Organizer
  第5回分子薬剤学東北セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K08373
[Presentation] インスリン抵抗性マウスにおける脳関門および脳実質のタンパク質発現および機能変動の解明2018
- Author(s)
  緒方星陵、伊藤慎悟、増田豪、大槻純男
- Organizer
  創剤フォーラム第24回若手研究会
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 脳内への高分子送達に資する新規BBB透過性環状ペプチドの同定2018
- Author(s)
  山口駿介、伊藤慎悟、増田豪、大槻純男
- Organizer
  第12回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02590
[Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターの輸送機能特性と発現・局在解析2017
- Author(s)
  上村立記、伊藤慎悟
- Organizer
  平成28年度「脳クレアチン欠乏症候群」班会議及び研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-26293035
[Presentation] 脳クレアチン欠乏症候群に関する新規変異クレアチントランスポーターの輸送機能特異性と発現・局在解析2017
- Author(s)
  上村立記、伊藤慎悟
- Organizer
  平成28年度「脳クレアチン欠乏症候群」班会議及び研究会
- Place of Presentation
  東京
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] トランスオミクスによるオーファントランスポーターSLC22A18の生理機能解明2017
- Author(s)
  伊藤慎悟、本多玄太郎、赤澤貴憲、寺崎哲也、大槻純男
- Organizer
  第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08373
[Presentation] トランスオミクスによるSLC22A18の生理機能の解明2017
- Author(s)
  伊藤慎悟、本多玄太郎、赤澤貴憲、寺崎哲也、大槻純男
- Organizer
  第10回トランスポーター研究会九州部会
- Data Source
  KAKENHI-PROJECT-16K08373
[Presentation] オーファントランスポーターSLC22A18のタンパク質翻訳後修飾への関与2017
- Author(s)
  伊藤慎悟、本多玄太郎、赤澤貴憲、寺崎哲也、大槻純男
- Organizer
  日本プロテオーム学会2017
- Data Source
  KAKENHI-PROJECT-16K08373
[Presentation] SWATHによる網羅的タンパク質定量法を用いた薬物動態研究の新展開2017
- Author(s)
  伊藤慎悟
- Organizer
  第137 回日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08373
[Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターのクレアチン輸送活性低下とそのメカニズムの解明2016
- Author(s)
  上村立記、伊藤慎悟、太田悠介、立川正憲、平山未央、和田敬仁、寺崎哲也、大槻純男
- Organizer
  第40回　蛋白質と酵素の構造と機能に関する九州シンポジウム
- Place of Presentation
  鹿児島
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-26293035
[Presentation] SLC22A18 is involved in the proliferation of MCF-7 human breast cancer cells by altering cellular protein expression2016
- Author(s)
  Shingo Ito, Yu Fujino, Sumio Ohtsuki
- Organizer
  Japan-Turkey International Symposium on Pharmaceutical and Biomedical Sciences
- Place of Presentation
  Kumamoto, Japan
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08373
[Presentation] 新規変異クレアチントランスポーターのクレアチン輸送活性低下とそのメカニズムの解明2016
- Author(s)
  上村立記、伊藤慎悟、太田悠介、立川正憲、黒木未央、和田敬仁、寺崎哲也、大槻純男
- Organizer
  第9回トランスポーター研究会九州部会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-26293035
[Presentation] Effect of insulin signaling on the regulation of tight-junction integrity in hCMEC/D3 cells2016
- Author(s)
  Shingo Ito, Mari Yanai, Sumio Ohtsuki
- Organizer
  19th International Symposium on Signal Transduction at the Blood-Brain Barriers
- Place of Presentation
  コペンハーゲン
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01562
[Presentation] Effect of insulin signaling on the regulation of tight-junction integrity in hCMEC/D3 cells2016
- Author(s)
  Shingo Ito, Mari Yanai, Sumio Ohtsuki
- Organizer
  19th　International Symposium on Signal Transduction at the Blood-Brain-Barriers
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01562
[Presentation] オーファントランスポーターSLC22A18のタンパク質翻訳後修飾への関与2015
- Author(s)
  伊藤慎悟、本多玄太郎、赤澤貴憲、平山未央、寺崎哲也、大槻純男
- Organizer
  第10回トランスポーター研究会年会(JTRA2015)
- Place of Presentation
  東京、慶應義塾大学薬学部芝共立キャンパス
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-26860109
[Presentation] SLC22A18 regulates the proliferation of MCF-7 human breast cancer cells by altering cellular protein expression2015
- Author(s)
  伊藤慎悟
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860109
[Presentation] オーファントランスポーターのタンパク質翻訳後修飾への関与2015
- Author(s)
  本多玄太郎、赤澤貴憲、伊藤慎悟、仲村健司、平山未央、寺崎哲也、大槻純男
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎、長崎ブリックホール
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860109
[Presentation] Facilitation of cell proliferation by suppression of SLC22A18 in human breast cancer cells, MCF-72015
- Author(s)
  Yu Fujino, Shingo Ito, Mio Hirayama, Sumio Ohtsuki
- Organizer
  nternational Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
- Place of Presentation
  熊本、熊本大学薬学部大江キャンパス
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860109
[Presentation] 「脳クレアチン欠乏症候群の臨床研究班」の取り組み2015
- Author(s)
  和田敬仁，小坂仁，相田典子，後藤知英，露崎悠，新保裕子，加藤秀一，高野亨子，大槻純男，伊藤慎悟，立川正憲，黒澤裕子
- Organizer
  第57回日本小児神経学会
- Place of Presentation
  大阪
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 新規変異クレアチントランスポーターの機能と発現解析2015
- Author(s)
  上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
- Organizer
  第31回日本薬学会九州支部大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーターの発現・局在と輸送機能特性の解析2015
- Author(s)
  上村立記、伊藤慎悟、太田悠介、立川正憲、平山未央、和田敬仁、寺崎哲也、大槻純男
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 脳クレアチン欠乏症候群に関連する新規変異クレアチントランスポーター特性の解析2015
- Author(s)
  伊藤慎悟
- Organizer
  第36回部兄時の化合物研究会
- Place of Presentation
  東北大学、仙台
- Year and Date
  2015-08-08
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki: Changes in transport activity and cellular localization by a novel missense mutation in human creatine transporter found in Japanese cerebral creatine deficiency syndromes patients2015
- Author(s)
  Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
- Organizer
  Barcelona BioMed Conference Blood Braine Barrier
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Molecular genetic study and urine analysis of Japanese patients with cerebral creatine deficiency syndromes.2015
- Author(s)
  H. Shimbo, H. Osaka, M. Tachikawa, S. Ohtsuki, S. Ito, T. Goto, Y. Tsuyusaki, N. Aida, K. Kurosawa, Y. Kurosawa, H. Kato, K. Takano, T. Wada.
- Organizer
  65th American Society of Human Genetics
- Place of Presentation
  Baltimore
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Changes of cellular localization and transport activity by a novel mutation in creatine transporter associated with chronic cerebral creatine depletion2015
- Author(s)
  Tatsuki Uemura, Shingo Ito, Yusuke Ota, Masanori Tachikawa, Takahito Wada, Mio Hirayama, Tetsuya Terasaki, Sumio Ohtsuki
- Organizer
  International Symposium on Chronic Inflammatory Diseases
- Place of Presentation
  Kumamoto
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] 新規変異クレアチントランスポーターの機能と発現解析
- Author(s)
  上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
- Organizer
  第31回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-26293035
[Presentation] ヒトクレアチントランスポーター変異症例におけるクレアチン輸送機能の解明
- Author(s)
  上村立記、伊藤慎悟、落合祐介、立川正憲、平山未央、和田敬仁、大槻純男
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293035

1. OHTSUKI Sumio (60323036)

# of Collaborated Projects: 7 results

# of Collaborated Products: 41 results
2. 増田豪 (70383940)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
3. WADA Takahito (70359727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. TERASAKI Tetsuya (60155463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 内田康雄 (70583590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 上家潤一 (10400269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 立川正憲 (00401810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. 新保裕子 (50724663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 小坂仁 (90426320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 川口桂 (10700164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 益田邦洋 (30569645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 寺崎哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Ito Shingo 伊藤 慎悟

ITO Shingo 伊藤 慎悟

伊藤 慎吾 イトウ シンゴ

Research Projects

Research Products

Co-Researchers

Identification of macrotranscytosis based on clarification of the molecular mechanism of transport of tissue barrier penetrating peptidesPrincipal Investigator

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New molecular mechanisms for membrane-mediated transcellular transport across the blood brain barrier

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患者由来同所移植モデル（PDOX）を用いた希少癌に対する治療法の探索研究

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Mcrotransport of the blood-brain barrier and its application to the permeable carrier.

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Regulation mechanism of cell senescence by orphan transporterPrincipal Investigator

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脳支援・防御機構としてのヒト脳関門におけるインスリン受容体機能の解明Principal Investigator

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Mechanism of cellular localization of mutated creatine transporter toward therapy for creatine deficiency syndromes

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Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes

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The pathological role of an orphan transporter in the regulation of cancer cell characteristicsPrincipal Investigator

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Identification of a novel cancer therapy target molecule by elucidating the physiological function of the orphan transporterPrincipal Investigator

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Involvement of prostaglandin transport system at the blood-brainbarrier in the drug-induced vascular disorder in the brain.Principal Investigator

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PROTEOMICS-BASED ANALYSIS OF BLOOD-BRAIN BARRIER TRANSPORT SYSTEM

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[Journal Article] Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood?Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells2021

Author(s)

Ito Shingo 伊藤慎悟

ITO Shingo 伊藤慎悟

伊藤慎吾イトウシンゴ