Saitoh Shin-ichiroh 齋藤伸一郎

Connect your ORCID iD *help

… Alternative Names

SAITOH Shin-ichiroh 齋藤伸一郎

SAITOH Shin-Ichiroh 斉藤伸一郎

SITOH Shin-ichiroh 斉藤伸一郎

齋藤伸一郎サイトウシンイチロウ

斉藤伸一郎サイトウシンイチロウ

Less

Researcher Number	90361625
Other IDs
Affiliation (Current)	2025: 和歌山県立医科大学, 先端医学研究所, 教授
Affiliation (based on the past Project Information) *help	2024: 和歌山県立医科大学, 先端医学研究所, 教授 2016 – 2022: 東京大学, 医科学研究所, 准教授 2009 – 2015: The University of Tokyo, 医科学研究所, 助教 2005 – 2006: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Experimental pathology / Biological Sciences / Immunology / Basic Section 49030:Experimental pathology-related Except Principal Investigator Basic Section 49070:Immunology-related / Immunology / Biological Sciences
Keywords	Principal Investigator TLR7 / 全身性エリトマトーデス / 樹状細胞 / 低分子量G蛋白質 / Arl8b / 自己免疫疾患 / エンドソーム / ライソソーム / 原発性胆汁性胆管炎 / 2型自己免疫性肝炎 … More / Rab7a / Toll-like receptor 7 / Toll-like Receptor / Toll-like receptor / 抗原提示 / エンドソーム成熟異常 / 核酸認識Toll-like receptor / 電子顕微鏡 / TLR3 / 低分子量Gタンパク質 / 制御性T細胞 / 全身性エリテマトーデス / 1型インターフェロン / SLEモデルマウス / small G protein / 形質細胞様樹状細胞 / 胆管炎 / T細胞 / 小胞輸送 / 自己免疫性貧血 / 自己免疫性肝炎 / 応答ゾーン / Rab7aゾーン / Arl8bゾーン / 電子顕微鏡によるトポロジー解析 / 炎症性サイトカイン / インターフェロン / 核酸認識Toll-like Receptor / 免疫制御 / MRL-lpr / Toll-like Receptor 7 / 免疫 / RNA / 形質細胞用樹状細胞 / 内在性リガンド / pristane / 角膜炎 / 自己免疫病 / SLE / plasmacytoid DC / 全身性炎症 / 古典的樹状細胞 / Yeast Two Hybrid / MS解析 / LC-MS / UNC93b1 / Unc93b1 / 自然免疫 / TLR9 / LC-Ms/Ms解析 / ノックインマウス / 核酸認識 / LPS / PLD / TLR4 … More Except Principal Investigator 自然免疫 / Toll様受容体 / 核酸認識Toll-like receptor / 低分子量G蛋白質 / 樹状細胞 / 自己抗体 / 自己免疫性溶血性貧血 / 病原体センサー / 病源体センサー / 自然得免疫 Less

自己免疫性溶血性貧血の発生機序及び自己抗体産生メカニズムの解明
- Principal Investigator
  
  齋藤良子 (森良子)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Wakayama Medical University
Elucidation of the mechanisms using different response zones in endosome and lysosome by nucleic acid-sensing Toll-like receptorsPrincipal Investigator
- Principal Investigator
  
  齋藤伸一郎
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of the onset mechanism of Type 2 Autoimmune Hepatitis and related liver diseasesPrincipal Investigator
- Principal Investigator
  
  Saitoh Shin-Ichiroh
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Elucidation of response zones for nucleic acid-sensing Toll-like receptorsPrincipal Investigator
- Principal Investigator
  
  齋藤伸一郎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Elusidation of regulatory mechanism for regulatory Tcells by Arl8bPrincipal Investigator
- Principal Investigator
  
  Saitoh Shin-Ichiroh
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
A role of Arl8b for the development of SLEPrincipal Investigator
- Principal Investigator
  
  Saitoh Shin-Ichiroh
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
Identification of an internal TLR7 ligand related to the onset of Systemic Lupus ErythematosusPrincipal Investigator
- Principal Investigator
  
  SAITOH Shin-Ichiroh
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
Molecular basis underlying Toll-like receptor logistics
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Ｓｍａｌｌ　Ｇ　ｐｒｏｔｅｉｎが制御する角膜炎発症機構の解明Principal Investigator
- Principal Investigator
  
  齋藤伸一郎
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Toll like receptors; their endogenous ligands and mechanism regulating their activities
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of the regulatory mechanisms for balancing TLR7 and TLR9 responses by UNC93b1Principal Investigator
- Principal Investigator
  
  SAITOH Shin-ichiroh
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
TLR4のシグナル伝達におけるPHISPHOLIPASED(PLD)の役割Principal Investigator
- Principal Investigator
  
  齋藤伸一郎 (斉藤伸一郎)
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

[Book] Advanced in Nucleic Acid Therapeutics.2019
- Author(s)
  Saitoh S and Miyake K.
- Publisher
  Springer
- Data Source
  KAKENHI-PUBLICLY-18H04856
[Book] 医学のあゆみ, 自然免疫の最前線,2018
- Author(s)
  齋藤　伸一郎
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PUBLICLY-18H04856
[Book] エンドトキシン・自然免疫２０2017
- Author(s)
  齋藤　伸一郎
- Total Pages
  3
- Publisher
  日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-16K15253
[Book] Toll-like Receptor 7が1型インターフェロンを産生するにはLFA-1が重要な役割を果たしている2017
- Author(s)
  齋藤　伸一郎
- Total Pages
  3
- Publisher
  日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-26293083
[Book] 臨床免疫・アレルギー科2013
- Author(s)
  齋藤　伸一郎
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PUBLICLY-24117706
[Book] 臨床免疫・アレルギー科2013
- Author(s)
  齋藤　伸一郎
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25670189
[Book] Innate Immune Regulation and Cancer Immunotherapy2011
- Author(s)
  齋藤伸一郎
- Total Pages
  11
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-21590528
[Book] Innate Immune Regulation and Cancer Immunotherapy2011
- Author(s)
  Saitoh, S
- Publisher
  Toll-like Receptors and Their Regulatory Mechanisms
- Data Source
  KAKENHI-PROJECT-21590528
[Book] Regulatory molecules required for nucleotide-sensing Toll-like receptors2009
- Author(s)
  Saitoh S, & Miyake K
- Total Pages
  227
- Publisher
  Immunol. Rev
- Data Source
  KAKENHI-PROJECT-21590528
[Book] Chaperones and transportproteins regulate TLR4 trafficking and activation2009
- Author(s)
  Saitoh S
- Total Pages
  214
- Publisher
  Immunobiology
- Data Source
  KAKENHI-PROJECT-21590528
[Journal Article] The anti‐TLR4 monoclonal antibody Sa15‐21 enhances inflammatory cytokine production in LPS‐stimulated macrophages2023
- Author(s)
  Chowdhury Sajid Iftekhar、Inui Masanori、Yamazaki Tatsuya、Tomono Susumu、Takagi Hidekazu、Biswas Mrityunjoy、Saitoh Shin‐Ichiroh、Miyake Kensuke、Akashi‐Takamura Sachiko
- Journal Title
  
  FEBS Letters
  
  Volume: - Issue: 9 Pages: 1-15
- DOI
  10.1002/1873-3468.14619
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-19K08500, KAKENHI-PROJECT-20K11635
[Journal Article] Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment2022
- Author(s)
  Miyake Kensuke、Shibata Takuma、Fukui Ryutaro、Sato Ryota、Saitoh Shin-Ichiroh、Murakami Yusuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 941931-941937
- DOI
  10.3389/fimmu.2022.941931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-21K15464
[Journal Article] Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment.2021
- Author(s)
  Miyake K, Saitoh S-I, Fukui R, Shibata T, Sato R, and Murakami Y.
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 835-840
- DOI
  10.1093/intimm/dxab037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04900, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-20H03466
[Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020
- Author(s)
  Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: 32 Issue: 12 Pages: 785-798
- DOI
  10.1093/intimm/dxaa055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-19K16685, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
[Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019
- Author(s)
  Furusho K, Shibata T, Sato R, Fukui R, Motoi Y, Zhang Y, Saitoh SI, Ichinohe T, Moriyama M, Nakamura S, Miyake, K.
- Journal Title
  
  International immunology.
  
  Volume: 31 Issue: 3 Pages: 167-173
- DOI
  10.1093/intimm/dxy075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22723, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-16K08827, KAKENHI-PROJECT-19K22635
[Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018
- Author(s)
  Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.
- Journal Title
  
  Nat Immunol.
  
  Volume: 19 Issue: 10 Pages: 1071-1082
- DOI
  10.1038/s41590-018-0203-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-16K08827, KAKENHI-ORGANIZER-15H05935
[Journal Article] Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production2018
- Author(s)
  Kusumoto Yutaka、Okuyama Hiromi、Shibata Takuma、Konno Kazunori、Takemoto Yusuke、Maekawa Daisuke、Kononaga Tomoyuki、Ishii Takashi、Akashi-Takamura Sachiko、Saitoh Shin-ichiroh、Ikebuchi Ryoyo、Moriya Taiki、Ueda Mizuki、Miyake Kensuke、Ono Shiro、Tomura Michio
- Journal Title
  
  Cellular Immunology
  
  Volume: 324 Pages: 33-41
- DOI
  10.1016/j.cellimm.2017.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-15K09491
[Journal Article] Mechanisms controlling nucleic acid-sensing Toll-like receptors2018
- Author(s)
  Miyake Kensuke、Shibata Takuma、Ohto Umeharu、Shimizu Toshiyuki、Saitoh Shin-Ichiroh、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 2 Pages: 43-51
- DOI
  10.1093/intimm/dxy016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16K08827
[Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017
- Author(s)
  Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 1592-1592
- DOI
  10.1038/s41467-017-01687-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-16K08827
[Journal Article] The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA2017
- Author(s)
  Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1 Pages: 44042-44054
- DOI
  10.1038/srep44042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16K08827
[Journal Article] Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling2017
- Author(s)
  4.Iijima J, Kobayashi S, Kitazume S*, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh S, Akashi-Takamura S, Miyake K, Miyoshi E, and Taniguch N
- Journal Title
  
  Glycobiology
  
  Volume: 2017 Issue: 11 Pages: 1006-1015
- DOI
  10.1093/glycob/cwx075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08601, KAKENHI-PROJECT-15K14481, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-16H05226, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-26860201, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-15K09491
[Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos2017
- Author(s)
  Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
- Journal Title
  
  J Cell Sci
  
  Volume: 130 Issue: 20 Pages: 3568-3577
- DOI
  10.1242/jcs.200519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-26110005, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05127, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-16K15253
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6119-6119
- DOI
  10.1038/ncomms7119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
[Journal Article] Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes2015
- Author(s)
  Li X, Saitoh S, Shibata T, Tanimura N, Fukui R, Miyake K.
- Journal Title
  
  International immunology
  
  Volume: 27 Issue: 2 Pages: 83-94
- DOI
  10.1093/intimm/dxu086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015
- Author(s)
  Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, *Miyake K
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 5853-5853
- DOI
  10.1038/ncomms6853
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-25291010
[Journal Article] Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Strand RNA Sensing2015
- Author(s)
  Murakami Y, Fukui R, Motoi Y, Kanno A, Shibata T, Tanimura N, Saitoh S, Miyake K
- Journal Title
  
  Journal of Immunology
  
  Volume: 193 Issue: 10 Pages: 5208-5217
- DOI
  10.4049/jimmunol.1400386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses.2015
- Author(s)
  Kimura T, Endo S, Inui M, Saitoh S, Miyake K, Takai T.
- Journal Title
  
  J Immunol.
  
  Volume: 194 Issue: 11 Pages: 5426-5436
- DOI
  10.4049/jimmunol.1402006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-26293083
[Journal Article] Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing2014
- Author(s)
  Murakami Y, Fukui R, Motoi Y, Kanno A, Shibata T, Tanimura N, Saitoh SI, *Miyake K
- Journal Title
  
  J Immunol
  
  Volume: 193 Pages: 5208-5217
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253032
[Journal Article] The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of TLR4/MD2 complex at the plasma membrane2013
- Author(s)
  Tanimura N, Saitoh S, Ohto U, Akashi-Takamura A, Fujimoto Y, Fukase K, Shimizu T, Miyake K
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Issue: 6 Pages: 307-314
- DOI
  10.1093/intimm/dxt071
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A2013
- Author(s)
  Yamakawa N, Ohto U, Akashi-Takamura S, Takahashi K, Saitoh SI, Tanimura N, Suganami T, Ogawa Y, Shibata T, Shimizu T, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 25 Pages: 45-52
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013
- Author(s)
  Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 25 Issue: 7 Pages: 413-422
- DOI
  10.1093/intimm/dxt007
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117004, KAKENHI-PROJECT-21390088, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-24390076, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25670189, KAKENHI-PLANNED-21117002
[Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013
- Author(s)
  Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
- Journal Title
  
  Nat. Commun.
  
  Volume: 4 Issue: 1 Pages: 1949-1949
- DOI
  10.1038/ncomms2949
- NAID
  120005359107
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-25860353
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like Receptor 7 and 9-trafficking2011
- Author(s)
  福井竜太郎、齋藤伸一郎, 他
- Journal Title
  
  Immunity
  
  Volume: 35 Pages: 68-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590528
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7-and TLR9-trafficking2011
- Author(s)
  Fukui R, Saitoh S, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, YoshidaN, & Miyake K
- Journal Title
  
  Immunity
  
  Volume: 35 Pages: 69-81
- Data Source
  KAKENHI-PROJECT-21590528
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9-trafficking2011
- Author(s)
  Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K
- Journal Title
  
  Immunity
  
  Volume: 35 Pages: 69-81
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking2011
- Author(s)
  Fukui R
- Journal Title
  
  Immunity
  
  Volume: 35 Issue: 1 Pages: 69-81
- DOI
  10.1016/j.immuni.2011.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059010, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-21390298, KAKENHI-PROJECT-22500286, KAKENHI-PROJECT-22659097, KAKENHI-PROJECT-22790454, KAKENHI-PUBLICLY-23118520
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, and Miyake K
- Journal Title
  
  J. Exp. Med.
  
  Volume: 206 Pages: 1339-1350
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Chaperons and transport proteins regulate TLR4 trafficking and activation.2009
- Author(s)
  齋藤伸一郎
- Journal Title
  
  Immunobiology 214
  
  Pages: 594-600
- Data Source
  KAKENHI-PROJECT-21590528
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing.2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, Miyake K.
- Journal Title
  
  J.Exp.Med
  
  Volume: 206 Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA-but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, & Miyake K
- Journal Title
  
  J Exp Med
  
  Volume: 206 Pages: 1339-1350
- Data Source
  KAKENHI-PROJECT-21590528
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.2009
- Author(s)
  福井竜太郎, 齋藤伸一郎
- Journal Title
  
  The Journal of Experimental Medicine 206
  
  Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590528
[Journal Article] Mechanism regulating cell surface expression and activation of Toll-like receptor 42007
- Author(s)
  Saitoh Shin-Ichiroh
- Journal Title
  
  The Chemical Record 6・6
  
  Pages: 311-319
- Data Source
  KAKENHI-PROJECT-17790319
[Presentation] 樹状細胞のエンドソーム異常によりαβ T細胞とγδ T細胞を活性化することで自己免疫性肝炎と原発性胆汁性胆管炎を引き起こす2022
- Author(s)
  齋藤　伸一郎
- Organizer
  第２７回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-20H03466
[Presentation] Endosome abnormality in dendritic cells causes type 2 autoimmune hepatitis and primary biliary cholangitis ( Tentative title)2022
- Author(s)
  Shin-Ichiroh Saitoh
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-20H04900
[Presentation] Endosomal abnormalities in dendritic cells cause autoimmune liver diseases2022
- Author(s)
  Shin-Ichiroh Saitoh, Kenichi Harada, Yoshiko Mori Saitoh, Ge-Hong Sun-Wada, Tamami Denda, Yasunori Ota, Hiroshi Sagara, Yuji Watanabe, Yoh Wada, and Kensuke Miyake
- Organizer
  第５１回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03466
[Presentation] 樹状細胞のエンドソーム異常による2型自己免疫性肝炎と原発性胆汁性胆管炎の発症2022
- Author(s)
  齋藤　伸一郎
- Organizer
  第９５回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03466
[Presentation] Loss of Rab7a in dendritic cells causes type 2 autoimmune hepatitis2021
- Author(s)
  Shin-Ichiroh Saitoh, Yoshiko Mori Saitoh, Ge-Hong Sun-Wada, Yoh Wada, Kensuke Miyake
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04900
[Presentation] Loss of Rab7a in dendritic cells causes type 2 autoimmune hepatitis and primary biliary cholangitis2021
- Author(s)
  Shin-Ichiroh Saitoh, Yoshiko Mori Saitoh, Kensuke Miyake
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PUBLICLY-20H04900
[Presentation] Loss of Rab7a in dendritic cells causes type 2 autoimmune hepatitis and primary biliary cholangitis2021
- Author(s)
  Shin-Ichiroh Saitoh, Yoshiko Mori Saitoh, Kensuke Miyake.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03466
[Presentation] Loss of Rab7a in dendritic cells causes type 2 autoimmune hepatitis2021
- Author(s)
  Shin-Ichiroh Saitoh, Yoshiko Mori Saitoh, Ge-Hong Sun-Wada, Yoh Wada, Kensuke Miyake.
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03466
[Presentation] Cd11c-Cre+ Rab7aflox/flox mice develop autoimmune hepatitis2018
- Author(s)
  Shin-Ichiroh Saitoh, Yoshiko Mori Saitoh, and Kensuke Miyake
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PUBLICLY-18H04856
[Presentation] TLR3とTLR7はそれぞれ異なる小胞にて異なる低分子量G蛋白質により制御を受けている2018
- Author(s)
  齋藤　伸一郎
- Organizer
  第23回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PUBLICLY-18H04856
[Presentation] ADP-ribosylation factor-like 8b is required for the pathogenesis of mouse models of Systemic Lupus Erythematosus.2017
- Author(s)
  Shin-Ichiroh Saitoh,　Yoshiko Mori Saitoh,　 Katsuaki Sato,　Kenji Kontani, and Kensuke Miyake
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15253
[Presentation] Arl8bは全身性エリテマトーデスモデルマウスBXSB.Yaaの病気の発症に関わっている.2017
- Author(s)
  齋藤　伸一郎
- Organizer
  第23回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-16K15253
[Presentation] Arl8bは全身性エリテマトーデスモデルマウスBXSB.Yaaの病気の発症に関わっている.2017
- Author(s)
  齋藤　伸一郎
- Organizer
  第23回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-26293083
[Presentation] ADP-ribosylation factor-like 8b is required for the pathogenesis of mouse models of Systemic Lupus Erythematosus.2017
- Author(s)
  Shin-Ichiroh Saitoh,　Yoshiko Mori Saitoh,　 Katsuaki Sato,　Kenji Kontani, and Kensuke Miyake
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-26293083
[Presentation] Metabolic permission for IFNa induction is connected by Toll-like Receptor 7 trafficking2016
- Author(s)
  Shin-Ichiroh Saitoh
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-16K15253
[Presentation] Toll-like receptor 7の移動は代謝センサーmTorC1による1型インターフェロン産生の制御と結びついている2016
- Author(s)
  齋藤　伸一郎
- Organizer
  日本エンドトキシン・自然免疫研究会
- Place of Presentation
  鹿児島大学　郡元キャンパス
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26293083
[Presentation] Metabolic permission for IFNa induction is connected by Toll-like Receptor 7 trafficking2016
- Author(s)
  Shin-Ichiroh Saitoh
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-26293083
[Presentation] Toll-like receptor 7の移動は代謝センサーmTorC1による1型インターフェロン産生の制御と結びついている2016
- Author(s)
  齋藤　伸一郎
- Organizer
  日本エンドトキシン・自然免疫研究会
- Place of Presentation
  鹿児島大学　郡元キャンパス
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16K15253
[Presentation] The Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated inflammation2013
- Author(s)
  齋藤　伸一郎
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PUBLICLY-24117706
[Presentation] THE ARF-LIKE GTPASE ARL8B DRIVES TLR7 INTO TYPE I INTERFERON-MEDIATED INFLAMMATION2013
- Author(s)
  齋藤　伸一郎
- Organizer
  第19回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  ロイヤルオークホテルスパ＆ガーガーデンズ(大津市)
- Data Source
  KAKENHI-PUBLICLY-24117706
[Presentation] The Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated inflammation2013
- Author(s)
  齋藤　伸一郎
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-25670189
[Presentation] THE ARF-LIKE GTPASE ARL8B DRIVES TLR7 INTO TYPE I INTERFERON-MEDIATED INFLAMMATION2013
- Author(s)
  齋藤　伸一郎
- Organizer
  第19回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  ロイヤルオークホテル　スパ&ガーガデンズ(滋賀県大津市）
- Data Source
  KAKENHI-PROJECT-25670189
[Presentation] Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated autoimmunity.2012
- Author(s)
  Saitoh Shin-Ichiroh
- Organizer
  第４１回日本免疫学会学術集会ワークショップ
- Place of Presentation
  兵庫県
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PUBLICLY-24117706
[Presentation] Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated autoimmunity2012
- Author(s)
  Saitoh Shin-Ichiroh
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡県
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PUBLICLY-24117706
[Presentation] A GTPase driving TLR7 into type I interferon-mediated autoimmunity.2012
- Author(s)
  Saitoh Shin-Ichiroh
- Organizer
  The 12th Biennial International Endotoxin Innate Immunity Society(IEIIS) meeting
- Place of Presentation
  東京都
- Year and Date
  2012-10-24
- Data Source
  KAKENHI-PUBLICLY-24117706
[Presentation] UNC93b1を介したToll-like receptor (TLR)7と9の制御2009
- Author(s)
  齋藤伸一郎
- Organizer
  第18回内毒素LPS研究会
- Place of Presentation
  東京大学
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21590528

1. MIYAKE Kensuke (60229812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. OHTO Umeharu (90451856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. NAKANISHI Hiroki (10466740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKAMURA Sachiko (00325599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 齋藤良子 (20362337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. INUI Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 有井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 赤司祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高井俊行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 紺谷圏二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 牟田達史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 川口しのぶ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saitoh Shin-ichiroh 齋藤 伸一郎

SAITOH Shin-ichiroh 齋藤 伸一郎

SAITOH Shin-Ichiroh 斉藤 伸一郎

SITOH Shin-ichiroh 斉藤 伸一郎

齋藤 伸一郎 サイトウ シンイチロウ

斉藤 伸一郎 サイトウ シンイチロウ

Research Projects

Research Products

Co-Researchers

自己免疫性溶血性貧血の発生機序及び自己抗体産生メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms using different response zones in endosome and lysosome by nucleic acid-sensing Toll-like receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the onset mechanism of Type 2 Autoimmune Hepatitis and related liver diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of response zones for nucleic acid-sensing Toll-like receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Elusidation of regulatory mechanism for regulatory Tcells by Arl8bPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of Arl8b for the development of SLEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of an internal TLR7 ligand related to the onset of Systemic Lupus ErythematosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis underlying Toll-like receptor logistics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ｓｍａｌｌ Ｇ ｐｒｏｔｅｉｎが制御する角膜炎発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Toll like receptors; their endogenous ligands and mechanism regulating their activities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the regulatory mechanisms for balancing TLR7 and TLR9 responses by UNC93b1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TLR4のシグナル伝達におけるPHISPHOLIPASED(PLD)の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Saitoh Shin-ichiroh 齋藤伸一郎

SAITOH Shin-ichiroh 齋藤伸一郎

SAITOH Shin-Ichiroh 斉藤伸一郎

SITOH Shin-ichiroh 斉藤伸一郎

齋藤伸一郎サイトウシンイチロウ

斉藤伸一郎サイトウシンイチロウ

Ｓｍａｌｌ　Ｇ　ｐｒｏｔｅｉｎが制御する角膜炎発症機構の解明Principal Investigator