OOKOSHI Tadakazu 大越忠和

Researcher Number	90362037
Other IDs
Affiliation (based on the past Project Information) *help	2019: 福井大学, 学術研究院医学系部門, 助教 2016 – 2017: 福井大学, 学術研究院医学系部門, 助教 2007 – 2015: University of Fukui, 医学部, 助教 2006: 福井大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Human pathology / Experimental pathology / Kidney internal medicine Except Principal Investigator Experimental pathology / Biophysics / Biological Sciences / Science and Engineering
Keywords	Principal Investigator アミロイドーシス / β2-ミクログロブリン / 透析アミロイドーシス / 血液透析 / 細胞毒性 / 実験病理学 / 細胞傷害 / 滑膜線維芽細胞 / リソソーム / エンドサイトーシス … More / 滑膜細胞 / アミロイド線維 / β2‐ミクログロブリン / β2ミクログロブリン / タンパク質 / 人工血液透析 / 脂質 / 蛋白質 / 人口血液透析 … More Except Principal Investigator β2-ミクログロブリン / アミロイド線維 / 透析アミロイドーシス / アミロイドーシス / 病理学 / 蛋白質 / トランスジェニックマウス / 透析アミロイド症 / アルツハイマー病 / 透析アミロイド－シス / 血清アミロイドP成分 / 細胞傷害 / C反応性蛋白質 / 細胞外シャペロン / アミロイド / 蛋白質品質管理 / シャペロン / Aβ蛋白質 / 血清アミロイド成分 / トランジェニックマウス / 試験管内分子間相互作用 / 分子間相互作用 Less

β2-ミクログロブリンアミロイド線維による細胞傷害機構、及び細胞刺激作用の解析Principal Investigator
- Principal Investigator
  
  大越忠和
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Molecular pathogenesis of amyloidosis: Integration of protein chemistry, mouse models and clinical pathology
- Principal Investigator
  
  Naiki Hironobu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
analysis of the mechanism of bone and joint destruction by beta2-microglobulin amyloid deposionPrincipal Investigator
- Principal Investigator
  
  Okoshi Tadakazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
The mechanism of extracellular protein quality control by extracellular chaperone
- Principal Investigator
  
  Ozawa Daisaku
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models
- Principal Investigator
  
  Naiki Hironobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
The inhibition mechanism of protein aggregation by extracellular chaperone
- Principal Investigator
  
  OZAWA Daisaku
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and articular destruction in dialysis related amyloidosisPrincipal Investigator
- Principal Investigator
  
  OOKOSHI Tadakazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
アミロイド線維形成を制御する生体分子環境及び線維沈着による細胞傷害機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
アミロイド線維形成をもたらす生体分子環境および線維沈着による細胞傷害機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
アミロイド線維形成を引き起こす生体内分子環境の解明
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Fukui
Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
リゾリン脂質によるβ2-ミクログロブリンアミロイド線維の伸長促進効果Principal Investigator
- Principal Investigator
  
  大越忠和
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  University of Fukui

All 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] 老化とアミロイドーシス2018
- Author(s)
  内木宏延, 長谷川一浩, 山口格, 大越忠和, 遠藤芳徳
- Journal Title
  
  病理と臨床
  
  Volume: 36 Pages: 110-115
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作，大越忠和，長谷川一浩，内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和，小澤大作，山口格，長谷川一浩，内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和、小澤大作、山口格、長谷川一浩、内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26860236
[Journal Article] Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 29077-29077
- DOI
  10.1038/srep29077
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] アミロイド線維の形成、沈着と臓器障害の分子機構2016
- Author(s)
  大越忠和、内木宏延
- Journal Title
  
  医学のあゆみ
  
  Volume: 258
- Data Source
  KAKENHI-PROJECT-26860236
[Journal Article] アミロイド線維の形成・沈着と臓器障害の分子機構2016
- Author(s)
  大越忠和, 内木宏延
- Journal Title
  
  医学のあゆみ
  
  Volume: 258 Pages: 615-620
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作, 大越忠和, 長谷川一浩, 内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 29 Pages: 199-206
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和, 小澤大作, 山口格, 長谷川一浩, 内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] Molecular pathogenesis ofhuman amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.2016
- Author(s)
  Naiki H, Okoshi T, Ozawa D, Yamaguchi I, Hasegawa K.
- Journal Title
  
  Pathol Int.
  
  Volume: ;66(4) Issue: 4 Pages: 193-201
- DOI
  10.1111/pin.12394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] Endocytosed β2-microglobulin amyloid fibrils induce necrosis and apoptosis of rabbit synovial fibroblasts by disrupting endosomal/lysosomal membranes: A novel mechanism on the cytotoxicity of amyloid fibrils.2015
- Author(s)
  Okoshi, T., Yamaguchi, I., Ozawa, D., Hasegawa, H., Naiki, H.
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Endocytosed β2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils.2015
- Author(s)
  Okoshi T, Yamaguchi I, Ozawa D, Hasegawa K, Naiki H
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 9 Pages: e0139330-e0139330
- DOI
  10.1371/journal.pone.0139330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06965, KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236
[Journal Article] HBME-1 and CD15 immunocytochemistry in the follicular variant of thyroid papillary carcinoma.2015
- Author(s)
  Ohta, M., Ookoshi, T., Naiki, H., Imamura, Y.
- Journal Title
  
  Pathol Int.
  
  Volume: 65 Issue: 3 Pages: 119-125
- DOI
  10.1111/pin.12252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木宏延，長谷川一浩，小澤大作，大越忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木　宏延, 長谷川　一浩, 小澤　大作, 大越　忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: An in vitro model of cerebral amyloid angiopathy.2013
- Author(s)
  Hasegawa K, Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1834 Issue: 8 Pages: 1624-1631
- DOI
  10.1016/j.bbapap.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570129, KAKENHI-PROJECT-24770150, KAKENHI-PROJECT-25293094
[Journal Article] Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: an in vitro model of cerebral amyloid angiopathy2013
- Author(s)
  Hasegawa K., Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  BiochimBiophys Acta
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Journal Title
  
  The Proceedings of the XIIIth International Symposium on Amyloidosis
  
  Pages: 45-47
- Data Source
  KAKENHI-PROJECT-24770150
[Journal Article] Inhibition of β_2-microglobulin amyloid fibril formation by α_2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Lysophospholipids induce the nucleation and extension of β2-microglobulin-related amyloid fibrils at a neutral pH2008
- Author(s)
  Ookoshi, T. Hasegawa, K., Ohhashi, Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H.
- Journal Title
  
  Nephrol. Dial. Transplant 23(10)
  
  Pages: 3247-3255
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Procollagen C-proteinase enhancer-1(PCPE-1)interacts with β2-microglobulin(β2-m)and may help initiate β2-m amyloid fibril formation in connective tissues2008
- Author(s)
  Morimoto, H., Wada, J., Font, B., Mott, J.D., Hulmes D.J., Ookoshi, T., Naiki, H., Yasuhara, A., Nakatsuka, A., Fukuoka, K., Takatori, Y., Ichikawa, H., Akagi, S., Nakao, K., Makino, H.
- Journal Title
  
  Matrix Biol 27(3)
  
  Pages: 211-219
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] β_2-ミクログロブリンのアミロイド線維化2008
- Author(s)
  大越忠和, 他
- Journal Title
  
  腎と骨代謝 22
  
  Pages: 7-12
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] Growth of β2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH2008
- Author(s)
  Hasegawa, K., Tsutsumi-Yasuhara, S., Ookoshi, T., Ohhashi,Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H.
- Journal Title
  
  Biochem.J 416(2)
  
  Pages: 307-315
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] β_2-ミクログロブリンのアミロイド線維化2008
- Author(s)
  大越忠和, 他
- Journal Title
  
  腎と骨代謝 22
  
  Pages: 7-12
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Lysophospholipids induce the nucleation and extension of β2-microglobulin-related amyloid fibrils at a neutral pH2008
- Author(s)
  Ookoshi, T., et.al.
- Journal Title
  
  Nephrol. Dial. Transplant 23
  
  Pages: 3247-3255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] The anti-amyloidogenic effect is exerted against Alzheimer's β-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure2007
- Author(s)
  Hirohata, M., Hasegawa, K., Tsutsumi-Yasuhara, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., Naiki, H.
- Journal Title
  
  Biochemistry 46(7)
  
  Pages: 1888-1899
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Lysophospholipids Induce the Nucleation and Extension of β2-Microglobulin-Related Amyloid Fibrils at a Neutral pH
- Author(s)
  Ookoshi, T., et. al.
- Journal Title
  
  Nephrol. Dial. Transplant. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Lysophospholipids Induce the Nucleation and Extension of β_2-Microglobulin-Related Amyloid Fibrils at a Neutral pH
- Author(s)
  Ookoshi, T., et. al.
- Journal Title
  
  Nephrol. Dial. Transplant. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031014
[Presentation] Class I small leucine-rich proteoglycans(SLRPs) colocalize with the Aβ2M amyloid deposits: Implications for the roles of SLRP core proteins in the pathogenesis of dialysis-related amyloidosis.2018
- Author(s)
  Yamaguchi I, Kokubo Y, Yamashita T, Ueda M, Okoshi T, Matsumine A, Ando Y, Naiki H
- Organizer
  The XVIth International Symposium on Amyloidosis 2018 Kumamoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XV International Symposium on Amyloidosis
- Place of Presentation
  Sweden
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XVth International Symposium on Amyloidosis
- Place of Presentation
  Uppsala Consert and Congre(Sweden)
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分のアミロイド線維形成抑制および促進効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第4回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京）
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作，野村寮，Mangione P. Patrizia，長谷川一浩，大越忠和，Porcari Riccardo，Bellotti Vittorio，内木宏延
- Organizer
  第１６回日本蛋白質科学会
- Place of Presentation
  福岡県
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] 透析アミロイド沈着部位に共存するグリコサミノグリカン及びプロテオグリカンの検討－病理切片を用いた免疫組織化学的観察とプロテオーム解析－2015
- Author(s)
  山口　格, 大越　忠和, 内田　研造, 田崎　雅義, 山下　太郎, 安東　由喜雄, 内木　宏延
- Organizer
  第3回日本アミロイドーシス研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 滑膜線維芽細胞に対するβ2-ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越　忠和, 山口　格, 小澤　大作, 長谷川　一浩, 内木　宏延
- Organizer
  第 2 回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 滑膜線維芽細胞に対するβ2‐ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越忠和、山口格、長谷川一浩、小澤大作、内木宏延
- Organizer
  第2回日本アミロイドーシス研究会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-26860236
[Presentation] β2‐ミクログロブリンアミロイド線維の細胞毒性に関する検討2013
- Author(s)
  大越忠和
- Organizer
  アミロイドーシスに関する調査研究班　研究報告会
- Place of Presentation
  KKR ホテル東京
- Data Source
  KAKENHI-PROJECT-23790393
[Presentation] ビーズ表面に結合した細胞外マトリクス成分は、気液界面非存在下でアルツハイマー病βアミロイド線維の核形成を促進させる2013
- Author(s)
  長谷川　一浩, 小澤　大作, 大越　忠和, 内木　宏延
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  京都, 京都国際会議場
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリン線維の細胞毒性に関する検討2013
- Author(s)
  大越忠和
- Organizer
  アミロイドーシスに関する調査研究班・研究報告会
- Place of Presentation
  KKR ホテル東京
- Year and Date
  2013-01-24
- Data Source
  KAKENHI-PROJECT-23790393
[Presentation] β2-ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリン線維の滑膜線維芽細胞に対する細胞毒性の検討2013
- Author(s)
  大越忠和
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2013-06-08
- Data Source
  KAKENHI-PROJECT-23790393
[Presentation] β2‐ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越忠和
- Organizer
  第102回　日本病理学会総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23790393
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李　映昊, 櫻井一正, 柳　浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen, the Netherlands (口頭発表およびポスター発表)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李映昊, 櫻井一正, 柳浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, NaikiH
- Organizer
  XIII^<th>International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 遊離脂肪酸によるβ2-ミクログロブリンアミロイド線維伸長反応促進効果の解析2009
- Author(s)
  大越忠和, 他
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] リンゾン脂質のβ2-ミクログロブリンアミロイド線維伸長促進効果(II)-透析患者血漿を用いた検討2008
- Author(s)
  大越忠和, 他
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] リソリン脂質のβ2-ミクログロブリンアミロイド線維伸長促進効果(II)-透析患者血漿を用いた検討2008
- Author(s)
  大越忠和, 他
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] A novel cytotoxic mechanism of amyloid fibrils: Endocytosis-dependent necrosis and apoptosis of rabbit synovial fibroblasts by β2-microglobulin amyloid fibrils
- Author(s)
  T.Ookoshi, D.Ozawa, K.Hasegawa, H.Naiki
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis, Indiana, USA JW Marriott Down
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリンアミロイド線維は滑膜線維芽細胞内に取り込まれ毒性を発揮する－形態解析を中心に－
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25293094

1. NAIKI Hironobu (10227704)

# of Collaborated Projects: 13 results

# of Collaborated Products: 43 results
2. HASEGAWA Kazuhiro (60324159)

# of Collaborated Projects: 11 results

# of Collaborated Products: 36 results
3. OZAWA Daisaku (60554524)

# of Collaborated Projects: 7 results

# of Collaborated Products: 24 results
4. HIGUCH Keiichi (20173156)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. BAN Tadato (00579667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. GOTO Yuji (40153770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

OOKOSHI Tadakazu 大越 忠和

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β2-ミクログロブリンアミロイド線維による細胞傷害機構、及び細胞刺激作用の解析Principal Investigator

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analysis of the mechanism of bone and joint destruction by beta2-microglobulin amyloid deposionPrincipal Investigator

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analysis of the mechanism of bone and articular destruction in dialysis related amyloidosisPrincipal Investigator

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リゾリン脂質によるβ2-ミクログロブリンアミロイド線維の伸長促進効果Principal Investigator

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[Journal Article] 老化とアミロイドーシス2018

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[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016

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OOKOSHI Tadakazu 大越忠和