NAGAI Taku 永井拓

Researcher Number	90363647
External Links
Affiliation (based on the past Project Information) *help	2015: 鹿児島大学, 医歯学域医学系, 講師 2011 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 講師 2013: 鹿児島大学, 医歯学総合研究科, 講師 2007 – 2009: Kagoshima University, 大学院・医歯学総合研究科, 助教 2006: Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院医歯学総合研究科, 助手 2005: 鹿児島大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Cerebral neurosurgery / Immunology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator 膠原病・アレルギー・感染症内科学 / Digestive surgery
Keywords	Principal Investigator マクロファージ / 抗体 / 癌 / イムノトキシン / 抗体医薬 / 免疫原性 / 脳腫瘍 / 前臨床試験 / 抗体製剤 / 低分子高機能型抗体 … More / 炎症 / 葉酸受容体β / がん / 葉酸拮抗剤 / 葉酸誘導体 / 関節リウマチ … More Except Principal Investigator SCID / マクロファージ / イムノトキシン / 葉酸リセプター / Osteoclasts / Activated fibroblast-like cells / Macrophages / Rheumatoid arthritis / Folate receptor / Immunotoxin / 破骨細胞 / 活性化線維芽細胞 / SCI / 関節リウマチ / ヒト化抗FRαβ抗体 / CD68マクロファージ / FRβマクロファージ / caerulein誘導慢性膵炎 / miRNA / N-cadherin / EMT / nude mouse / fibrotic stroma / FRb receptor / migration / invasion / microRNA / FRbeta / miR-30 / tumor microenvironment / FRb-receptor / macrophage / CD133 / cancer stem cell / pancreatic cancer / アメリカ合衆国 / 抗体 / 国際情報交換 Less

ヒト化マウスを用いた卵巣がんの免疫回避機構の明確化と治療への応用Principal Investigator
- Principal Investigator
  
  永井拓
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kagoshima University
Analysis of the interaction between the folate receptor beta expression macrophages and cancer stem cells in pancreatic cancer invasion
- Principal Investigator
  
  TAKAO SONSHIN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kagoshima University
Therapy targeting folate receptor beta expressing macrophages in chronic inflammation
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kagoshima University
Characterization and targeting Folate receptor-beta expressed tumor associated macrophages in glioblastomaPrincipal Investigator
- Principal Investigator
  
  TAKU Nagai
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kagoshima University
Therapeutic targeting of folate receptor-beta expressing tumor-associated macrophages.Principal Investigator
- Principal Investigator
  
  NAGAI Taku
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kagoshima University
葉酸受容体βを介した葉酸の細胞内輸送機構の解明と抗炎症作用を示す葉酸誘導体の開発Principal Investigator
- Principal Investigator
  
  永井拓
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kagoshima University
A preclinical study using recombinant anti-folate receptor-beta immunotoxin for the treatment of rheumatoid arthritis
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kagoshima University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Patent

[Book] 次世代医薬開発に向けた抗体工学の最前線
- Author(s)
  永井拓
- Total Pages
  283
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Production of a High-affinity Monoclonal Antibody Reactive with Folate Receptors Alpha and Beta.2015
- Author(s)
  Nagai T, Furusho Y, Li H, Hasui K, Matsukita S, Sueyoshi K, Yanagi M, Hatae M, Takao S,　Matsuyama　T.
- Journal Title
  
  Monoclon Antib Immunodiagn Immunother.
  
  Volume: 34 Issue: 3 Pages: 181-190
- DOI
  10.1089/mab.2014.0072
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293288
[Journal Article] Depletion of folate receptor β-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis.2014
- Author(s)
  Li H, Nagai T, Hasui K, Matsuyama T.
- Journal Title
  
  Modern Rheumatology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Depletion of folate receptor β-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis2014
- Author(s)
  Li H, Nagai T, Hasui K, Matsuyama T.
- Journal Title
  
  Mod Rheumatol
  
  Volume: - Issue: 5 Pages: 816-822
- DOI
  10.3109/14397595.2013.879415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134, KAKENHI-PROJECT-25293288
[Journal Article] Depletion of folate receptorβ-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis2014
- Author(s)
  Hua Li, Taku Nagai, Kazuhisa Hasui, Takami Matsuyama
- Journal Title
  
  Modern Rheumatology
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages2012
- Author(s)
  Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
- Journal Title
  
  Journal of American Heart Association
  
  Volume: 1 Issue: 4
- DOI
  10.1161/jaha.112.003079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591105, KAKENHI-PROJECT-23592134, KAKENHI-PROJECT-24890178
[Journal Article] Clinical significance of folate receptor β-expressing tumor-associated macrophages in pancreatic cancer.2012
- Author(s)
  Kurahara H, Takao S, Kuwahata T, Nagai T, Ding Q, Maeda K, Shinchi H, Mataki Y, Maemura K, Matsuyama T, Natsugoe S.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 19 Issue: 7 Pages: 2264-71
- DOI
  10.1245/s10434-012-2263-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptorβ―expressing Macrophages2012
- Author(s)
  Furusho Y, Miyata M, Matsuyama T, Nagai T, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 1(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages.2012
- Author(s)
  Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: １（４）
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Immunohistochemistry of programmed cell death in archival human pathology specimens2012
- Author(s)
  Hasui K, Nagai T
- Journal Title
  
  Cells
  
  Volume: 1(2) Pages: 74-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis.2012
- Author(s)
  Nagai T, Kyo A, Hasui K, Takao S, Matsuyama T.
- Journal Title
  
  Arthritis Res Ther. 2012
  
  Volume: １４
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles.2012
- Author(s)
  Tsuneyoshi Y, Tanaka M, Nagai T, Sunahara N, Matsuda T, Sonoda T, Ijiri K, Komiya S, Matsuyama T.
- Journal Title
  
  Scand J Rheumatol.
  
  Volume: ４１（２） Pages: 132-40
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis2012
- Author(s)
  Nagai T, Kyo A, Hasui K, Takao S, Matsuyama T
- Journal Title
  
  Arthritis research & therapy
  
  Volume: 14(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine.)2012
- Author(s)
  Tanaka M, Nagai T
- Journal Title
  
  Innate Immun
  
  Volume: 18(2) Pages: 258-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis2012
- Author(s)
  Nagai T, Kyo A, Hasui K
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles2012
- Author(s)
  Tsuneyoshi Y, Nagai T
- Journal Title
  
  Scand J Rheumatol
  
  Volume: 41(2) Pages: 132-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Clinical significance of folate receptorβ-expressing tumor-associated macrophages in pancreatic cancer2012
- Author(s)
  Kurahara H, Nagai T
- Journal Title
  
  S. Ann Surg Oncol
  
  Volume: 19(7) Pages: 2264-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles2012
- Author(s)
  Tsuneyoshi Y, Tanaka M, Nagai T, Sunahara N, Matsuda T, Sonoda T, Ijiri K, Komiya S, Matsuyama T
- Journal Title
  
  Scand J Rheumatol
  
  Volume: 41(2) Pages: 132-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptorβ-Expressing Macrophages2012
- Author(s)
  Furusho Y, Nagai T
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 1(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134
[Journal Article] 炎症の遷延化とがんの増殖を抑制するイムノトキシン2009
- Author(s)
  永井拓松山隆美田中将志
- Journal Title
  
  ケミカルエンジニアリング 11
  
  Pages: 55-62
- Data Source
  KAKENHI-PROJECT-20790377
[Journal Article] Targeting tumor-associted macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor-beta.2009
- Author(s)
  Nagai T., Tanaka M., et al.
- Journal Title
  
  Cancer Immunol Immunother. 58
  
  Pages: 1577-1586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790377
[Journal Article] Targeting tumor-associated macrophages in an experiment al glioma model with a recombinant immunotoxin to folat e receptor beta2009
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Xu B, Michie SA, Hasui K, Hirano H, Arito K, Matsuyama T
- Journal Title
  
  Cancer Immunol Immunother (Online published)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790377
[Journal Article] 炎症の遷延化とがんの増殖を抑制するイムノトキシン2009
- Author(s)
  永井拓松山隆美田中将志
- Journal Title
  
  ケミカルエンジニアリング 11
  
  Pages: 55-62
- Data Source
  KAKENHI-PROJECT-20790377
[Journal Article] Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor-beta.2009
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Xu B, Michie SA, Hasui K, Hirano H, Arita K, Matsuyama T.
- Journal Title
  
  Cancer Immunol Immunother. 58
  
  Pages: 1577-1586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790377
[Journal Article] Limited distribution of folate-receptor beta expressing inflammatory macrophages in murine tissues.2008
- Author(s)
  Taku Nagai, Masashi Tanaka, et. al.
- Journal Title
  
  Modern Rheumatology 18
  
  Pages: 143-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790687
[Journal Article] Limited distribution of folate-receptor beta expressing inflammatory macrophages in murine tissues2008
- Author(s)
  Nagai T, Tanaka M, Matsuyama T
- Journal Title
  
  Mod. Rheumatol 18
  
  Pages: 143-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790377
[Journal Article] In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T
- Journal Title
  
  Arthritis ＆ Rheumatism. 54(10)
  
  Pages: 3126-3134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591051
[Journal Article] In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T.
- Journal Title
  
  Arthritis ＆ Rheumatism 54(10)
  
  Pages: 3126-3134
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591051
[Journal Article] In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T
- Journal Title
  
  Arthritis and Rheumatism 54(10)
  
  Pages: 3126-3134
- Data Source
  KAKENHI-PROJECT-18790687
[Journal Article] Ii vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T
- Journal Title
  
  Arthritis ＆ Rheumatism 54(10)
  
  Pages: 3126-34
- Data Source
  KAKENHI-PROJECT-17591051
[Journal Article] Effect of an immunotoxin to folate receptor-beta on bleomycin-induced experimental pulmonary fibrosis Clin.
- Author(s)
  Nagai T., Tanaka M., K Hasui, Shiramaha H., Kitajima S., Yonezawa S., Xu B., Matsuyama T.
- Journal Title
  
  Exp. Immunol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790377
[Patent] 強皮症治療剤2013
- Inventor(s)
  松山隆美、李花、永井拓
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-054090
- Filing Date
  2013-03-15
- Overseas
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 強皮症治療剤2013
- Inventor(s)
  松山隆美、梨花、永井拓
- Industrial Property Rights Holder
  国立大学法人　鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-054090
- Filing Date
  2013-07-07
- Data Source
  KAKENHI-PROJECT-23592134
[Patent] 強皮症治療剤2013
- Inventor(s)
  李花、松山隆美、永井拓
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23592134
[Patent] リコンビナント抗葉酸受容体-βイムノトキシンによる強皮症の治療2012
- Inventor(s)
  李花、松山隆美、永井拓、蓮井和久
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-281525
- Filing Date
  2012-12-25
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 葉酸リセプターα及びβを認識する抗体2012
- Inventor(s)
  松山隆美、永井拓、蓮井和久、高尾尊身
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-281525
- Filing Date
  2012-12-25
- Overseas
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 軟骨又は骨の破壊の診断薬2012
- Inventor(s)
  松山隆美、永井拓
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-241968
- Filing Date
  2012-11-01
- Overseas
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 葉酸リセプターαおよびβを認識する抗体2012
- Inventor(s)
  永井拓、松山隆美、古庄優子
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-25
- Data Source
  KAKENHI-PROJECT-23592134
[Patent] 特願2011-1808992011
- Inventor(s)
  松山隆美、永井拓
- Industrial Property Rights Holder
  松山隆美、永井拓
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23592134
[Patent] 間質性肺炎治療剤2009
- Inventor(s)
  永井拓, 松山隆美, 田中将志
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Industrial Property Number
  2009-004826
- Filing Date
  2009-02-27
- Data Source
  KAKENHI-PROJECT-20790377
[Patent] 間質性肺炎治療剤2009
- Inventor(s)
  永井拓松山隆美田中将志
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Industrial Property Number
  2009-004826
- Filing Date
  2009-02-27
- Data Source
  KAKENHI-PROJECT-20790377
[Patent] がん関連マクロファージを標的とした固形がん治療剤2008
- Inventor(s)
  永井拓, 松山隆美, 田中将志
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Industrial Property Number
  2008-130882
- Filing Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-20790377
[Patent] がん関連マクロファージを標的とした固形がん治療剤2008
- Inventor(s)
  永井拓松山隆美田中将志
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Industrial Property Number
  2008-130882
- Filing Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] Efficacy of an antibody reactive with human folate receptors-alpha and -beta in targeting cancer cells and TAMs2013
- Author(s)
  Nagai Taku、Hasui Kazuhisa、Matsuyama Takami、Takao Sonshin、Hatae Masayuki、Sueyoshi Kazunobu、Matsukida Sumika
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] 葉酸リセプターβ発現マクロファージを標的とした強皮症モデルの治療に関する研究2013
- Author(s)
  李花、永井拓、松山隆美
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  横浜
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] The detection of a soluble folate receptor beta in rheumatoid arthritis under anti-TNF therapy2013
- Author(s)
  永井拓、大坪秀雄、李花、松田剛正、松山隆美
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  横浜
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] Neoplastic features of florid pseudoepitheliomatous hyperplasia (FPH) in nasal NK/T-cell lymphoma (nNKTCL)2013
- Author(s)
  Hasui Kazuhisa、Nagai Taku
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] Efficacy of an antibody reactive with human folate receptorsαandβin targeting cancer cells and TAMs2013
- Author(s)
  Taku Nagai
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] Neoplastic features of florid pseudoepitheliomatous hyperplasia (FPH) in nasal NK/T-cell lymphoma (nNKTCL)2013
- Author(s)
  Hasui Kazuhisa、Nagai Taku、Furukawa Tatsuhiko、Kanekura Takuro、Kawano Yoshifumi、Matsuyama Takami、Aozasa Katsuyuki
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] New insight into pancreatic cancer progression associated with cancer stem cells and tumor-associated macrophages in cancer microenvironment2012
- Author(s)
  Qiang Ding, Taku Nagai
- Organizer
  Cell Symposia : Hallmarks of Cancer
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] Distribution and significance of folate receptorβ-expressing macrophages in pancreatic cancer2012
- Author(s)
  Takao S, Nagai T
- Organizer
  Pancreatic Cancer : Progress and Challenges
- Place of Presentation
  Lake Tahoe, USA
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] Immunotherapy of antigen-induced rat arthritis with an anti-folate receptor beta Recombinant immunotoxin2012
- Author(s)
  Taku Nagai, Nobuhiko Sunahara, Takemasa Matsuda, Takami Matsuyama
- Organizer
  第56回日本リウマチ学会
- Place of Presentation
  京都
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] Clinical significance of folate receptorβ-expressing macrophages in pancreatic cancer2012
- Author(s)
  Sonshin Takao, Taku Nagai
- Organizer
  The fourth international symposium on folate receptors and transporters
- Place of Presentation
  Cozumel, Mexico
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] Clinical significance of flolate receptor b-expressing tumor-associated macrophage (TAM) in pancreatic cancer2011
- Author(s)
  Takao S, Nagai T
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23592134
[Presentation] がん増殖の抑制と抗炎症作用を示す低分子高機能型抗体(イムノトキシン)科学技術振興機構2010
- Author(s)
  永井拓
- Organizer
  新技術説明会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] がん増殖の抑制と抗炎症作用を示す低分子高機能型抗体(イムノトキシン)2010
- Author(s)
  永井拓
- Organizer
  科学技術振興機構新技術説明会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] 肺線維症マウスにおける葉酸リセプターβ発現マクロファージの選択的除去の効果2009
- Author(s)
  永井拓
- Organizer
  日本リウマチ学会
- Place of Presentation
  東京
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] Targeting FR-beta macrophages as a novel strategy agrategy against gloioblastoma2009
- Author(s)
  永井拓
- Organizer
  日中病理学シンポジウム(招待講演)
- Place of Presentation
  済南市中国
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] 炎症の遷延化と腫瘍の増殖を抑制するイムノトキシン2009
- Author(s)
  永井拓
- Organizer
  キャンパスイノベーションセンター新技術説明会
- Place of Presentation
  東京
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] 葉酸受容体β陽性マクロファージを標的としたイムノトキシンのブレオマイシン誘発マウス肺線維症に対する治療効果の検討2009
- Author(s)
  永井拓
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] Targeting FR-beta macrophages as a novel strategy against glioblastoma2009
- Author(s)
  永井拓
- Organizer
  日中病理学シンポジウム(招待講演)
- Place of Presentation
  済南市中国
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] 関節リウマチとマクロファージの病態生理と新規分子標的薬剤の開発2008
- Author(s)
  永井拓
- Organizer
  児玉記念基礎医学研究奨励賞受賞記念講演
- Place of Presentation
  鹿児島
- Year and Date
  2008-02-28
- Data Source
  KAKENHI-PROJECT-18790687
[Presentation] Limited distribution of folate-receptor beta expressing inflammatory macrophages in murine tissues2008
- Author(s)
  Nagai T, Tanaka M, Matsu yama T
- Organizer
  第52回日本リウマチ学会
- Place of Presentation
  ロイトン札幌他(札幌市)
- Data Source
  KAKENHI-PROJECT-20790377
[Presentation] The Z39Ig: a specific marker of synovial A cells in RA synovium2007
- Author(s)
  Masashi Tanaka, Taku Nagai
- Organizer
  The 5th International Symposium of Molecular Pathology
- Place of Presentation
  鹿児島
- Year and Date
  2007-07-31
- Data Source
  KAKENHI-PROJECT-18790687
[Presentation] Production and characterization of monoclonal antibodies against human folate receptors
- Author(s)
  Nagai Taku、Matsuyama Takami
- Organizer
  International symposium on Folate Receptors and Transporters
- Place of Presentation
  Heemskerk Netherland
- Year and Date
  2014-09-30 – 2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-26462530
[Presentation] In vitro and in vivo efficacy of anti-folate receptor alpha and beta monoclonal antibody against ovarian cancer cells and TAMS
- Author(s)
  Nagai Taku、Li Hua、Matsuyama Takami、Takao Sonshin
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26462530
[Presentation] The roles of novel tumor-associated macrophages (TAMs) in invasion and metastasis of pancreatic cancer
- Author(s)
  Sonshin Takao, Qiang Ding, Taku Nagai, Hiroshi Kurahara, Makoto Yoshimitsu, Taisaku Kuwahata, Yumi Miyazaki, Ryoko Imakiire, Shoko Ueno, Toru Obara, Takami Matsuyama
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] Efficacy of an antibody reactive with human folate receptors a and b in targeting cancer cells and TAMs
- Author(s)
  Nagai T, Hasui K, Matsuyama T, Takao S, Hatae M, Sueyoshi K, Matsukida S
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293288

1. MATSUYAMA Takami (30145479)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. HIRANO Hirofumi (00264416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKAO SONSHIN (80171411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Matsubara Shyichiro (60199841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. DING QIANG (80457647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YOSHIMITSU MAKOTO (70404530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 李花 (70597517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中将志 (60381167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 松下格司 (00363630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. MIYATA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. FURUSHO Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGAI Taku 永井 拓

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ヒト化マウスを用いた卵巣がんの免疫回避機構の明確化と治療への応用Principal Investigator

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Analysis of the interaction between the folate receptor beta expression macrophages and cancer stem cells in pancreatic cancer invasion

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Therapy targeting folate receptor beta expressing macrophages in chronic inflammation

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Characterization and targeting Folate receptor-beta expressed tumor associated macrophages in glioblastomaPrincipal Investigator

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Therapeutic targeting of folate receptor-beta expressing tumor-associated macrophages.Principal Investigator

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葉酸受容体βを介した葉酸の細胞内輸送機構の解明と抗炎症作用を示す葉酸誘導体の開発Principal Investigator

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A preclinical study using recombinant anti-folate receptor-beta immunotoxin for the treatment of rheumatoid arthritis

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[Book] 次世代医薬開発に向けた抗体工学の最前線

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[Journal Article] Production of a High-affinity Monoclonal Antibody Reactive with Folate Receptors Alpha and Beta.2015

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[Journal Article] Depletion of folate receptor β-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis.2014

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[Journal Article] Depletion of folate receptor β-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis2014

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[Journal Article] Depletion of folate receptorβ-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis2014

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[Journal Article] Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages2012

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[Journal Article] Clinical significance of folate receptor β-expressing tumor-associated macrophages in pancreatic cancer.2012

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[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptorβ―expressing Macrophages2012

NAGAI Taku 永井拓