Arai Fumio 新井文用

… Alternative Names

ARAI Fumio 新井文用

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Researcher Number	90365403
Other IDs	https://orcid.org/0000-0003-1936-4907
Affiliation (Current)	2025: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 九州大学, 医学研究院, 教授 2014 – 2016: 九州大学, 医学(系)研究科(研究院), 教授 2014: 九州大学, 応用幹細胞医科学部門・幹細胞再生修復医学分野, 教授 2006 – 2011: 慶應義塾大学, 医学部, 講師 2004 – 2005: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields Except Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences
Keywords	Principal Investigator 造血幹細胞 / ニッチ / シェルタリン因子 / POT1 / 間葉系幹細胞 / 非対称分裂 / 幹細胞ニッチ / 骨芽細胞 / POT1a / シェルタリン … More / 自己複製分裂 / 細胞分裂 / 自己複製 / 再生医学 / 活性酸素種 / Pot1a / 人工ニッチ / 細胞分裂制御 / ニッチ分子 / 血管性ニッチ / 間葉系前駆細胞 / 活性酸素 / N-cadherin / 免疫老化 / Tリンパ球 / TPP1 / Itga8 / 骨内膜 / 造血幹細胞ニッチ / 代謝制御 / ミトコンドリア / TIN2 / 白血病幹細胞 / 対称・非対称分裂 / 機械学習モデル / 人工ニューラルネットワーク / 対称分裂 / 人工神経回路 / 老化 / Bmi1 / Angpt1 / テロメアDNAダメージ / DNA損傷応答 / 内科 / DNAダメージ / テロメア / Single cell定量PCRアレイ / β-catenin / VE-cadherin / 静止期造血幹細胞 / SP(sde-population) / ニッチ複合体 / 骨芽細胞性ニッチ / N-カドヘリン / アンジオポエチン-1 / Tie2 / Side-population … More Except Principal Investigator 造血幹細胞 / ニッチ / 間葉系幹細胞 / Foxp2 / 急性骨髄性白血病 / 造血支持 / DNA損傷 / テロメア / 分化制御 / 転写因子 / 間葉系ストローマ細胞 / 老化 / 発生・分化 / 静止期 / 細胞周期 / イギリス・スイス / 国際情報交換 / 造血幹細胞分裂 / ニッチ分子 / 幹細胞維持 / 単一細胞 / 娘幹細胞 / TIE2受容体 / thrombopoietin / mpl / TIE2 / Angiopoiedn-1 / ATM / Thrombopoietin / Mpl / 活性酸素 / Angiopoietin-1 / Tie2 / 自己複製能 / 骨芽細胞 Less

Elucidation of the mechanism of hematopoietic stem cell maintenance by newly identified bone marrow mesenchymal stem cells.Principal Investigator
- Principal Investigator
  
  新井文用
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
Overcoming T cell dysfunction with Shelterin factorPrincipal Investigator
- Principal Investigator
  
  新井文用
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
Function of telomere binding factors in normal and tumor hematopoietic microenvironments
- Principal Investigator
  
  細川健太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
Identification of transcriptional signaling networks that control the quality and quantity of the bone marrow microenvironment
- Principal Investigator
  
  Hosokawa Kentaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
Elucidating the functional regulation mechanism of the hematopoietic microenvironment (niche) by the shelterin factorPrincipal Investigator
- Principal Investigator
  
  Arai Fumio
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
Functional elucidation of shelterin factor TIN2 in leukemic stem cells and its application to the development of novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  Arai Fumio
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
Function of Foxp2 in the maintenance of hematopoietic stem cells.
- Principal Investigator
  
  Hosokawa Kentaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Elucidation of the mechanism of asymmetric division of hematopoietic stem cells using the next-generation artificial nichePrincipal Investigator
- Principal Investigator
  
  Arai Fumio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell division
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Prevention of age-related deregulation of hematopoietic stem cell function through the protection of telomeric DNAPrincipal Investigator
- Principal Investigator
  
  Arai Fumio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Functional analysis of symmetric division-related molecules in the regulation of self-renewal of hematopoietic stem cellsPrincipal Investigator
- Principal Investigator
  
  ARAI FUMIO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Analyses of hematopoietic stem cell division patterns in biomimetic culture conditions and optimization of culture condition for hematopoietic stem cells
- Principal Investigator
  
  IKUSHIMA Yoshiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
  Keio University
人工幹細胞ニッチ:造血ニッチ複合体の再構成による幹細胞増幅Principal Investigator
- Principal Investigator
  
  新井文用
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (S)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Molecular mechanism of the establishment and maintenance of the nteraction between hematopoietic stem cells and osteoblastic nichePrincipal Investigator
- Principal Investigator
  
  ARAI Fumio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Regulation of Hematopoietic Stem Cell Division in a Niche
- Principal Investigator
  
  SUDA Toshio
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
造血幹細胞の支持細胞「ニッチ細胞」としての骨芽細胞の機能解析Principal Investigator
- Principal Investigator
  
  新井文用
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Keio University

[Book] Stem Book2009
- Author(s)
  Arai F
- Publisher
  The Stem Cell Research Community, StemBook(in press)
- Data Source
  KAKENHI-PROJECT-18689024
[Book] Regulation of hematopoietic stem cells in the osteoblastic niche. Osteoimmunology : Interactions of the Immune and Skeletal System (Choi Y, edited)2007
- Author(s)
  Arai F, Suda T.
- Publisher
  Adv Exp Med Biol.
- Data Source
  KAKENHI-PROJECT-18689024
[Book] Osteo immunology: Interactions of the Immune and Skeletal System2007
- Author(s)
  Arai F
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18689024
[Book] Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Hematopoietic Stem Cells VI.2007
- Author(s)
  Arai F, Suda T.
- Publisher
  Ann N Y Acad Sci
- Data Source
  KAKENHI-PROJECT-18689024
[Book] Landes Bioscience/Eurekah.com2006
- Author(s)
  Arai F, Suda T.
- Publisher
  Endothelial and hematopoietic cells in the intraembryonic compartment. In Hematopoietic Stem Cell Development. (edited by Godin I and Cumano A)
- Data Source
  KAKENHI-PROJECT-18689024
[Book] Endothelial and Hematopoietic Cells in the Intra-Embryonic Compartment in Hematopoietic Stem Cells.2004
- Author(s)
  Arai F, et al.
- Publisher
  Eurekah.com and Kluwer Academic/Plenum Publisher
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis2023
- Author(s)
  Nakashima Kentaro、Kunisaki Yuya、Hosokawa Kentaro、Gotoh Kazuhito、Yao Hisayuki、Yuta Ryosuke、Semba Yuichiro、Nogami Jumpei、Kikushige Yoshikane、Stumpf Patrick S.、MacArthur Ben D.、Kang Dongchon、Akashi Koichi、Ohga Shouichi、Arai Fumio
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/s42003-023-05374-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18301, KAKENHI-PROJECT-23K07861, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K27626
[Journal Article] Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo2022
- Author(s)
  Konno K, Kobayashi-Sun J, Arai F, Kobayashi I, Sugiyama D.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: － Pages: 171-180
- DOI
  10.1007/7651_2021_459
- ISBN
  9781071624364, 9781071624371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03711
[Journal Article] MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.2022
- Author(s)
  Hayashi Y, Inoue D, et al.
- Journal Title
  
  Cell Reports
  
  Volume: VOLUME 39, ISSUE 6 Issue: 6 Pages: 110805-110805
- DOI
  10.1016/j.celrep.2022.110805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21622, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-21K16258, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-21H02711, KAKENHI-PROJECT-20J01911, KAKENHI-PROJECT-19K10024, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-21H02954
[Journal Article] Modeling Stem Cell Fates using Non-Markov Processes2021
- Author(s)
  Stumpf Patrick S.、Arai Fumio、MacArthur Ben D.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 28 Issue: 2 Pages: 187-190
- DOI
  10.1016/j.stem.2021.01.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] A novel method to purify neutrophils enables functional analysis of zebrafish hematopoiesis2020
- Author(s)
  Konno Katsuhiro、Kulkeaw Kasem、Sasada Manabu、Nii Takenobu、Kaneyuki Ayako、Ishitani Tohru、Arai Fumio、Sugiyama Daisuke
- Journal Title
  
  Genes to Cells
  
  Volume: 25 Issue: 12 Pages: 770-781
- DOI
  10.1111/gtc.12810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03412, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45? TER119?Erythroid and Lymphoid Progenitors2020
- Author(s)
  Gotoh Kazuhito、Kunisaki Yuya、Mizuguchi Soichi、Setoyama Daiki、Hosokawa Kentaro、Yao Hisayuki、Nakashima Yuya、Yagi Mikako、Uchiumi Takeshi、Semba Yuichiro、Nogami Jumpei、Akashi Koichi、Arai Fumio、Kang Dongchon
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 11 Pages: 101654-101654
- DOI
  10.1016/j.isci.2020.101654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08733, KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-18K11077, KAKENHI-PROJECT-19K22638
[Journal Article] Heterogeneity and ‘memory’ in stem cell populations2020
- Author(s)
  Stumpf Patrick S、Arai Fumio、MacArthur Ben D
- Journal Title
  
  Physical Biology
  
  Volume: 17 Issue: 6 Pages: 065013-065013
- DOI
  10.1088/1478-3975/abba85
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal2020
- Author(s)
  Arai Fumio、Stumpf Patrick S.、Ikushima Yoshiko M.、Hosokawa Kentaro、Roch Aline、Lutolf Matthias P.、Suda Toshio、MacArthur Ben D.
- Journal Title
  
  Cell Systems
  
  Volume: 11 Issue: 6 Pages: 640-652
- DOI
  10.1016/j.cels.2020.11.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08733, KAKENHI-PROJECT-19K16547, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing2020
- Author(s)
  Stumpf Patrick S.、Du Xin、Imanishi Haruka、Kunisaki Yuya、Semba Yuichiro、Noble Timothy、Smith Rosanna C. G.、Rose-Zerili Matthew、West Jonathan J.、Oreffo Richard O. C.、Farrahi Katayoun、Niranjan Mahesan、Akashi Koichi、Arai Fumio、MacArthur Ben D.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 736-746
- DOI
  10.1038/s42003-020-01463-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo.2019
- Author(s)
  Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K.
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 1 Pages: 145-158
- DOI
  10.1016/j.celrep.2019.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K22638, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.2019
- Author(s)
  Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
- Journal Title
  
  Science Advance
  
  Volume: 23 Issue: 1 Pages: 9060-9060
- DOI
  10.1126/sciadv.aau9060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06338, KAKENHI-PROJECT-18K19171, KAKENHI-PLANNED-26119006, KAKENHI-PROJECT-16H04148, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-16J04435, KAKENHI-PROJECT-16KT0175, KAKENHI-PROJECT-19K07288, KAKENHI-PLANNED-17H06350, KAKENHI-PUBLICLY-18H04428, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-16K15193
[Journal Article] Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis2019
- Author(s)
  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S., Takakura N.
- Journal Title
  
  Nature Commun,
  
  Volume: 10 Issue: 1 Pages: 1072-1072
- DOI
  10.1038/s41467-019-09028-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04797, KAKENHI-PUBLICLY-18H04897, KAKENHI-PROJECT-16H02470, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-15H05325, KAKENHI-PROJECT-26710005, KAKENHI-PROJECT-19K22553, KAKENHI-PROJECT-19K16742, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-19H05210, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-19H03496
[Journal Article] Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress2018
- Author(s)
  Tadokoro Yuko、Hoshii Takayuki、Yamazaki Satoshi、Eto Koji、Ema Hideo、Kobayashi Masahiko、Ueno Masaya、Ohta Kumiko、Arai Yuriko、Hara Eiji、Harada Kenichi、Oshima Masanobu、Oshima Hiroko、Arai Fumio、Yoshimura Akihiko、Nakauchi Hiromitsu、Hirao Atsushi
- Journal Title
  
  Cell Stem Cell
  
  Volume: 22 Issue: 5 Pages: 713-725
- DOI
  10.1016/j.stem.2018.04.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09919, KAKENHI-PUBLICLY-17H05638, KAKENHI-PUBLICLY-18H05095, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-15H02361, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-16K09824, KAKENHI-PROJECT-17K19585, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04164
[Journal Article] The role of telomere binding molecules for normal and abnormal hematopoiesis.2018
- Author(s)
  Hosokawa K, Arai F.
- Journal Title
  
  Int J Hematol.
  
  Volume: 印刷中 Issue: 6 Pages: 646-655
- DOI
  10.1007/s12185-018-2432-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09907, KAKENHI-PROJECT-17H04208
[Journal Article] Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.2018
- Author(s)
  Yamauchi T, et al.
- Journal Title
  
  Cancer Cell.
  
  Volume: 33 Issue: 3 Pages: 386-400
- DOI
  10.1016/j.ccell.2018.01.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-17H01567, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-15J10130, KAKENHI-PROJECT-17K15042
[Journal Article] Guest editorial: Regulatory signaling in normal and abnormal hematopoiesis2018
- Author(s)
  Arai Fumio
- Journal Title
  
  International Journal of Hematology
  
  Volume: 107 Issue: 6 Pages: 624-626
- DOI
  10.1007/s12185-018-2460-0
- Data Source
  KAKENHI-PROJECT-17H04208
[Journal Article] Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression2017
- Author(s)
  Ali Mohamed A. E.、Fuse Kyoko、Tadokoro Yuko、Hoshii Takayuki、Ueno Masaya、Kobayashi Masahiko、Nomura Naho、Vu Ha Thi、Peng Hui、Hegazy Ahmed M.、Masuko Masayoshi、Sone Hirohito、Arai Fumio、Tajima Atsushi、Hirao Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 11442-11442
- DOI
  10.1038/s41598-017-11909-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09824, KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K09919, KAKENHI-PROJECT-17K19585, KAKENHI-PUBLICLY-16H01199, KAKENHI-PUBLICLY-17H05638, KAKENHI-PROJECT-15H02361, KAKENHI-PROJECT-17H04208
[Journal Article] The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age2017
- Author(s)
  Hosokawa Kentaro、MacArthur Ben D.、Ikushima Yoshiko Matsumoto、Toyama Hirofumi、Masuhiro Yoshikazu、Hanazawa Shigemasa、Suda Toshio、Arai Fumio
- Journal Title
  
  Nature Communications
  
  Volume: 8(804) Issue: 1 Pages: 804-818
- DOI
  10.1038/s41467-017-00935-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09907, KAKENHI-PROJECT-16K19067, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-17H04208
[Journal Article] Functional analysis of Protection of Telomeres 1a (Pot1a) in regulation of hematopoietic stem cell aging2017
- Author(s)
  Hosokawa K, Macarthur BD, Ikushima Y, Toyama H, Masuhiro Y, Hanazawa S, Suda T, Arai F.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 8 Pages: 942-949
- DOI
  10.11406/rinketsu.58.942
- NAID
  130006067976
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09907, KAKENHI-PROJECT-26221309
[Journal Article] Stem Cell Differentiation as a Non-Markov Stochastic Process2017
- Author(s)
  Stumpf Patrick S.、Smith Rosanna C.G.、Lenz Michael、Schuppert Andreas、Muller Franz-Josef、Babtie Ann、Chan Thalia E.、Stumpf Michael P.H.、Please Colin P.、Howison Sam D.、Arai Fumio、MacArthur Ben D.
- Journal Title
  
  Cell Systems
  
  Volume: 5 Issue: 3 Pages: 268-282.e7
- DOI
  10.1016/j.cels.2017.08.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04208
[Journal Article] Self renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.2016
- Author(s)
  Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, inkel T, Suda T, Lin CP, Frenette PS, Ito K
- Journal Title
  
  Science
  
  Volume: 354(6316) Issue: 6316 Pages: 1156-1160
- DOI
  10.1126/science.aaf5530
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-26462826
[Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016
- Author(s)
  Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
- Journal Title
  
  Blood
  
  Volume: 128(5) Issue: 5 Pages: 638-649
- DOI
  10.1182/blood-2016-01-694810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15J04258, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Determining C-Myb protein levels can isolate functional hematopoietic stem cell subtypes.2014
- Author(s)
  Sakamoto H, Takeda N, Arai F, Hosokawa K, Garcia P, Suda T, Frampton J, Ogawa M
- Journal Title
  
  Stem Cells
  
  Volume: 33 Issue: 2 Pages: 479-490
- DOI
  10.1002/stem.1855
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-24591400, KAKENHI-PROJECT-24689041, KAKENHI-PROJECT-25670453, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-26670471, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26221309
[Journal Article] Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.2013
- Author(s)
  Yamashita M, Nitta E, Nagamatsu G, Ikushima YM, Hosokawa K, Arai F, Suda T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 441 Issue: 1 Pages: 196-201
- DOI
  10.1016/j.bbrc.2013.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J40105, KAKENHI-PROJECT-13J05828, KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23618011, KAKENHI-PUBLICLY-24116522, KAKENHI-PROJECT-24689041, KAKENHI-PROJECT-25670453, KAKENHI-PROJECT-25893234
[Journal Article] Niche regulation of hematopoietic stem cells in the endosteum.2009
- Author(s)
  Arai F
- Journal Title
  
  Ann N Y Acad Sci 1176
  
  Pages: 36-46
- Data Source
  KAKENHI-PROJECT-21679004
[Journal Article] Niche Regulation of Hematopoietic Stem Cells in the Endosteum. The Role of Thrombopoietin/Mpl Signaling in the Maintenance of Quiescent Hematopoietic Stem Cells2009
- Author(s)
  Arai F
- Journal Title
  
  Ann N Y Acad Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice.2009
- Author(s)
  Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T.
- Journal Title
  
  Biochem Biophys Res Commun 378
  
  Pages: 467-472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.2009
- Author(s)
  Hato T, Kimura Y, Morisada T, Koh GY, Miyata K, Tabata M, Kadomatsu T, Endo M, Urano T, Arai F, et al.
- Journal Title
  
  Biochem Biophys Res Commun 381
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL2008
- Author(s)
  Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T
- Journal Title
  
  Genes Dev 22
  
  Pages: 986-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell cycle arrest2008
- Author(s)
  Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada Y, Arai F, Hirao A, Suda T
- Journal Title
  
  Cell Stem Cell 2
  
  Pages: 170-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Fbxw7 acts as a critical failsafe against premature loss of hematopoietic stem cells and development of T-ALL.2008
- Author(s)
  Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nagamatsu G, Nakamura Y, Gomei Y, Iwasaki H, Shima H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
- Journal Title
  
  Genes Dev 22
  
  Pages: 986-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Stem Cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell cycle arrest.2008
- Author(s)
  Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T.
- Journal Title
  
  Cell Stem Cell. 2
  
  Pages: 170-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] dentification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity.2008
- Author(s)
  Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A.
- Journal Title
  
  Stem Cells. 26
  
  Pages: 3237-3246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Wnt signaling in the niche.2008
- Author(s)
  Suda T, Arai F.
- Journal Title
  
  Cell 132
  
  Pages: 729-730
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007
- Author(s)
  Miyamoto K, Y. Araki K, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama K, Harada M, Motoyama N, Suda T, Hirao A
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 101-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Regulation of hematopoietic stem cells in the osteoblastic niche2007
- Author(s)
  Arai F
- Journal Title
  
  Adv Exp Med Biol 602
  
  Pages: 61-67
- NAID
  40015350814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Thrombopoietin/Mpl signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.2007
- Author(s)
  Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T.
- Journal Title
  
  Cell Stem Cell. 363
  
  Pages: 685-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Role of stem cell niche in the maintenance of hematopoietic stem cells.2007
- Author(s)
  Arai F
- Journal Title
  
  Inflammation and Regeneration 27
  
  Pages: 117-123
- NAID
  10019482602
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Thrombopoietin/Mpl signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche2007
- Author(s)
  Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyazaki H, Takahashi T, Suda T
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 685-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.2007
- Author(s)
  Hosokawa K, Arai F, Yoshihara H, Nakamura Y, Gomei Y, Iwasaki H, Miyamoto K, Shima H, Ito K, Suda T.
- Journal Title
  
  Biochem Biophys Res Commun. 363
  
  Pages: 578-583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche.2007
- Author(s)
  Fumio Arai
- Journal Title
  
  Ann N Y Acad Sci (in press)
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Regulation of reactive oxygen species by Atm is essential for proper response to DNA double strand breaks in lymphocytes.2007
- Author(s)
  Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A.
- Journal Title
  
  J. Immunol. 178
  
  Pages: 103-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Maintenance of quiescent hematopoietic stem cells in the osteoblasticniche2007
- Author(s)
  Arai F
- Journal Title
  
  Ann N Y Acad Sci 1106
  
  Pages: 41-53
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.2007
- Author(s)
  Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.
- Journal Title
  
  Leukemia. 21(1)
  
  Pages: 136-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Regulation of hematopoietic stem cells in the osteoblastic niche.2007
- Author(s)
  Fumio Arai
- Journal Title
  
  Osteoimmunology : Interactions of the Immune and Skeletal System (in press)
- NAID
  40015350814
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Foxo3a is essential for maintenance of hematopoietic stem cell pool.2007
- Author(s)
  Miyamoto K, Araki K, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama K-I, Harada M, Motoyama N, Suda T, Hirao A.
- Journal Title
  
  Cell Stem Cell. 1
  
  Pages: 101-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.2006
- Author(s)
  Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T.
- Journal Title
  
  Biochem Biophys Res Commun. 351
  
  Pages: 993-998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Regulation of hematopoietic stem cell and its interaction with stem cell niche.2006
- Author(s)
  Arai F.
- Journal Title
  
  J Oral Biosci 48
  
  Pages: 22-29
- NAID
  120006665069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.2006
- Author(s)
  Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T
- Journal Title
  
  Nature Med 12
  
  Pages: 446-451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.2006
- Author(s)
  Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y and Suda T.
- Journal Title
  
  Nat Med, 12
  
  Pages: 446-451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Regulation of hematopoietic stem cells by the niche2005
- Author(s)
  Fumio Arai
- Journal Title
  
  Trends Cardiovasc Med 15・2
  
  Pages: 75-79
- NAID
  10017576055
- Data Source
  KAKENHI-PROJECT-16790542
[Journal Article] Regulation of hematopoiesis by the osteoblastic niche2005
- Author(s)
  Fumio Arai
- Journal Title
  
  Clin Calcium 15・7
  
  Pages: 73-79
- Data Source
  KAKENHI-PROJECT-16790542
[Journal Article] Regulation of hematopoiesis and its interaction with stem cell niche2005
- Author(s)
  Fumio Arai
- Journal Title
  
  Int J Hematol 82・5
  
  Pages: 371-376
- NAID
  10016916628
- Data Source
  KAKENHI-PROJECT-16790542
[Journal Article] Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.2004
- Author(s)
  Arai F, et al.
- Journal Title
  
  Cell 118
  
  Pages: 149-161
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.2004
- Author(s)
  Fumio Arai
- Journal Title
  
  Cell 118・2
  
  Pages: 149-161
- Data Source
  KAKENHI-PROJECT-16790542
[Journal Article] Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.2004
- Author(s)
  Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T
- Journal Title
  
  Cell 118
  
  Pages: 149-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.2004
- Author(s)
  Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Nakagata N, Ikeda Y, Tak W. Mak, Suda T
- Journal Title
  
  Nature 431
  
  Pages: 997-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16002011
[Journal Article] Cadherin-based adhesion is a otential target for niche nipulation to protect matopoietic stem cells in adult bone marrow
- Author(s)
  Hsokawa K, Arai F, Yoshihara H, wasaki H, Hembree M, Yin T, akamura N, Gomei Y, Takubo K, hiama H, Matsuoka S, Li L, Suda T.
- Journal Title
  
  Cell Stem Cell (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] IRF-2 protects quiescent HSCs from type-I interferon-dependent exhaustion.
- Author(s)
  Sato T, Onai N, Yoshihara H, Arai F ,Suda T, Ohteki T.
- Journal Title
  
  Nat Med (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689024
[Journal Article] Regulation of hematopoietic stem cells by the niche.
- Author(s)
  Fumio Arai
- Journal Title
  
  Trends in Cardiovascular Medicne (印刷中)
- NAID
  10017576055
- Data Source
  KAKENHI-PROJECT-16790542
[Presentation] POT1a is essential for mesenchymal niches supporting B cell development2022
- Author(s)
  Nakashima K, Kunisaki Y, Hosokawa K, Yao H, Yuta R, Akashi K, Ohga S, Arai F
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03711
[Presentation] Identification and characterization of integrin α8-positive MSCs located in the endosteal niche2022
- Author(s)
  Yuta R, Yao H, Hosokawa K, Kunisaki Y, Semba Y, Arai F
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03711
[Presentation] Regulation of asymmetric division of hematopoietic stem cell by Angiopoietin-12018
- Author(s)
  Arai Fumio、MacArthur Ben D.
- Organizer
  Japan Society for the Promotion of Science and National University of Singapore joint 2nd symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04208
[Presentation] POT1a deficiency in mesenchymal niche cells results in bone marrow failures and skeletal retardation2018
- Author(s)
  Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Shouichi Ohga, Fumio Arai
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09907
[Presentation] The novel mesenchymal stromal niche cell in the bone marrow endosteum2018
- Author(s)
  Fumio Arai
- Organizer
  9th International Conference and Exhibition on Tissue Science and Regenerative Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04208
[Presentation] Identification of novel mesenchymal stromal cells that have the potential to support hematopoietic stem cell activity2017
- Author(s)
  Arai Fumio
- Organizer
  7th International Conference on Tissue Engineering and Regenerative Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04208
[Presentation] 造血幹細胞の未分化性維持における転写因子Foxp2の機能解析2017
- Author(s)
  Saki Morimoto, Kentaro Hosokawa, Yuya Kunisaki, Haruka Imanishi, Tomoko Hyoda, Yasufumi Uehara, Fumio Arai
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09907
[Presentation] Pot1 maintains haematopoietic stem cell activity by protecting against DNA damage and metabolic alterations2017
- Author(s)
  Arai Fumio
- Organizer
  8th International Conference on Tissue Science and Regenerative Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04208
[Presentation] Foxp2 is necessary for maintenance of quiescence in hematopoietic stem cells.2017
- Author(s)
  Kentaro Hosokawa, Saki Morimoto, Yuya Kunisaki, Haruka Imanishi, Tomoko Hyoda, Yasufumi Uehara, and Fumio Arai
- Organizer
  ISEH 46th Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09907
[Presentation] 造血幹細胞の自己複製・分化制御2016
- Author(s)
  新井文用
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] Function of Pot1 in the maintenance of hematopoietic stem cell activity under stress2016
- Author(s)
  Fumio Arai
- Organizer
  5th International Conference on Tissue Engineering & Regenerative Medicine
- Place of Presentation
  Berlin, Germany
- Year and Date
  2016-09-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] Pot1 maintains hematopoietic stem cell activity under stress.2016
- Author(s)
  Fumio Arai
- Organizer
  Japan Society for the Promotion of Science and National University of Singapore joint symposium.
- Place of Presentation
  Singapore
- Year and Date
  2016-01-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] Pot1 maintains hematopoietic stem cell activity under stress2016
- Author(s)
  Fumio Arai
- Organizer
  第14回　幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場（兵庫）
- Year and Date
  2016-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] シングルセル解析の最先端2016
- Author(s)
  新井文用
- Organizer
  第17回日本検査血液学会
- Place of Presentation
  福岡市
- Year and Date
  2016-08-06
- Invited
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] 造血幹細胞の自己複製・分化制御2016
- Author(s)
  新井文用
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] シングルセル解析の最先端2016
- Author(s)
  新井文用
- Organizer
  第17回日本検査血液学会
- Place of Presentation
  福岡市
- Year and Date
  2016-08-06
- Invited
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] 造血幹細胞の自己複製・分化制御2016
- Author(s)
  新井　文用
- Organizer
  第78回　日本血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] Pot1 maintains hematopoietic stem cell activity under stress.2016
- Author(s)
  Fumio Arai
- Organizer
  Japan Society for the Promotion of Science and National University of Singapore joint symposium.
- Place of Presentation
  Singapore
- Year and Date
  2016-01-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] Introduction of hematopoietic stem cell niche.2015
- Author(s)
  Fumio Arai
- Organizer
  ISEH (international society for experimental hematology), 44th Annual Scientific Meeting
- Place of Presentation
  京都
- Year and Date
  2015-09-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] Introduction of hematopoietic stem cell niche.2015
- Author(s)
  Fumio Arai
- Organizer
  ISEH 44th Annual Scientific Meeting
- Place of Presentation
  京都
- Year and Date
  2015-09-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] 単一細胞レベルでの娘細胞解析に基づくAngpt1の造血幹細胞分裂パターン決定における作用について2014
- Author(s)
  生島芳子, Ben D MacArthur, Patrick S Stumph, 細川健太郎, Alain Roch, Matthias P Lutolf, 須田年生, 新井文用
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-25893234
[Presentation] Regulation of hematopoietic stem cell activity during aging2014
- Author(s)
  Fumio Arai
- Organizer
  3rd Cancer Stem Cell Symposium
- Place of Presentation
  福岡市
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] Regulation of hematopoietic stem cell activity during aging2014
- Author(s)
  新井文用
- Organizer
  3rd Cancer Stem Cell Symposium
- Place of Presentation
  福岡市
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] 造血幹細胞の制御機構2009
- Author(s)
  新井文用
- Organizer
  第51回歯科基礎医学会学術大会・総会.サテライトシンポジウム
- Place of Presentation
  新潟市
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-21679004
[Presentation] Hematopoietic Stem Cell Niche in Bone Marrow2009
- Author(s)
  新井文用
- Organizer
  2nd Annual Congress of Regenerative Medicine & Stem Cell at CMBF 2009
- Place of Presentation
  Dalian, China
- Year and Date
  2009-08-09
- Data Source
  KAKENHI-PROJECT-21679004
[Presentation] Fractionated osteoblastic niche cells enhances the homing activity of hematopoietic stem cells.2009
- Author(s)
  新井文用
- Organizer
  51th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21679004
[Presentation] Hematopoietic Stem Cells in the Niche2009
- Author(s)
  新井文用
- Organizer
  2009 World Stem Cell Summit
- Place of Presentation
  Baltimore, MD, USA
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-21679004
[Presentation] 骨芽細胞と造血幹細胞ニッチ2009
- Author(s)
  新井文用
- Organizer
  第27回日本骨代謝学会学術集会
- Place of Presentation
  大阪市
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21679004
[Presentation] Hematopoietic stem cell niche2009
- Author(s)
  Arai F
- Organizer
  The 5th General Assembly with Asian Symposium-2009
- Place of Presentation
  Kobe, Japan
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Hematopoietic stem cell niche2009
- Author(s)
  Arai F.
- Organizer
  The 5th General Assembly with Asian Symposium-2009
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] 幹細胞のニッチ制御2008
- Author(s)
  新井文用
- Organizer
  第7回日本再生医療学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-03-14
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Niche regulation of hematopoietic stem cells in the endosteum2008
- Author(s)
  Arai F
- Organizer
  International Conference and Workshop. Hematopoietic Stem Cells VII
- Place of Presentation
  Meersburg, Germany
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Niche regulation of hematopoietic stem cells in the endosteum.2008
- Author(s)
  Arai F.
- Organizer
  International Conference and Workshop. Hematopoietic Stem Cells VII.
- Place of Presentation
  Meersburg, Germany
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Interaction of N-cadherin with beta-catenin is involved in the maintenance of hematopoietic stem cell quiescence in the osteoblastic niche.2007
- Author(s)
  Arai F
- Organizer
  5th ISSCR Annual Meeting
- Place of Presentation
  Cairns, Queensland,Australia
- Year and Date
  2007-06-19
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Interaction of N-cadherin with b-catenin is involved in then maintenance of hematopoietic stem cell quiescence in the osteoblastic niche.2007
- Author(s)
  Arai F, Hosokawa K, Yoshihara H, Takubo K, Matsuoka S, Miyamoto K, Nakamura Y, Gomei Y, Suda T.
- Organizer
  5th International Society for Stem Cell Research Annual Meeting
- Place of Presentation
  Cairns, Australia.
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] 造血幹細胞のニッチ制御2007
- Author(s)
  新井文用
- Organizer
  第49回歯科基礎医学会学術大会・総会
- Place of Presentation
  北海道大学
- Year and Date
  2007-08-31
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Regulation of the hematopoietic stem cell and its interaction with the osteoblastic niche.2007
- Author(s)
  Arai F.
- Organizer
  Gordon Research Conference, Bone & Teeth
- Place of Presentation
  University of New England, Biddeford, ME, USA
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] 骨髄微小環境と造血幹細胞制御2007
- Author(s)
  新井文用
- Organizer
  第61回日本口腔科学会学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Regulation of the hematopoietic stem cell and its interaction with the osteoblastic niche2007
- Author(s)
  Arai F
- Organizer
  Gordon Research Conference, Bone & Teeth
- Place of Presentation
  University of New England, Biddeford, ME
- Year and Date
  2007-07-17
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Regulation of hematopoietic stem cells by the niche.2006
- Author(s)
  Arai F.
- Organizer
  Stem Cell Biology and Regenerativec Medicine-from Bench to Bedside.
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2006-01-14
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Regulation of hematopoietic stem cell and its interaction with stem cell niche.2006
- Author(s)
  Arai F.
- Organizer
  Hiroshima conference on education and science in dentistry, 2006.
- Place of Presentation
  Hiroshima, Japan
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Maintenance of stem cells in the niche. International Conference and Workshop.2006
- Author(s)
  Arai F.
- Organizer
  Hematopoietic Stem Cells VI.
- Place of Presentation
  Tubingen, Germany.
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Regulation of hematopoietic stem cells in the osteoblastic niche.2006
- Author(s)
  Arai F.
- Organizer
  1st International Conference on Osteoimmunology : Interaction of the Immune and Skeletal Systems.
- Place of Presentation
  Crete, Greece.
- Data Source
  KAKENHI-PROJECT-18689024
[Presentation] Protection of telomeres 1による造血幹細胞の自己複製の制御
- Author(s)
  新井文用
- Organizer
  第14回日本再生医療学会
- Place of Presentation
  横浜市
- Year and Date
  2015-03-19 – 2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] The niche factor Angiopoietin-1 regulates stem and progenitor cell numbers by controlling hematopoietic stem cell division asymmetry
- Author(s)
  新井文用
- Organizer
  第12回幹細胞シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] Role of Pot1 in the regulation of hematopoietic stem cell activity
- Author(s)
  Fumio Arai
- Organizer
  2015 US-Japan Meeting on Malignant Hematopoiesis and Stem Cells
- Place of Presentation
  Waikoloa, HI, USA
- Year and Date
  2015-03-16 – 2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26293228
[Presentation] The niche factor Angiopoietin-1 regulates stem and progenitor cell numbers by controlling hematopoietic stem cell division asymmetry
- Author(s)
  新井文用
- Organizer
  第12回幹細胞シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] Single cell-based analyses of cell division pattern of hematopoietic stem cells
- Author(s)
  Ikushima YM, MacArthur BD, Hosokawa K, Lutolf MP, Suda T, Arai F
- Organizer
  75th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-25893234
[Presentation] Role of Pot1 in the regulation of hematopoietic stem cell activity
- Author(s)
  Fumio Arai
- Organizer
  2015 US-Japan Meeting on Malignant Hematopoiesis and Stem Cells
- Place of Presentation
  Waikoloa, HI, USA
- Year and Date
  2015-03-16 – 2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26670471
[Presentation] Protection of telomeres 1による造血幹細胞の自己複製の制御
- Author(s)
  新井文用
- Organizer
  第14回日本再生医療学会
- Place of Presentation
  横浜市
- Year and Date
  2015-03-19 – 2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-26293228

1. HOSOKAWA Kentaro (90569584)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. MACARTHUR Ben D.

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. SUDA Toshio (60118453)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. 八尾尚幸 (90835282)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. MIYAMOTO Takeshi (70383768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. MATSUOKA Sahoko (20317340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. TAKUBO Keiyo (50502788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. NAGAMATSU Go (70453545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. YOSHIHARA Hiroki (90348706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. IKUSHIMA Yoshiko (00571366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Takizawa Hitoshi (10630866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Ryuji Yokokawa (10411216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 国崎祐哉 (80737099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. STUMPF Patrich S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. LUTOLF Matthias P.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 上野将也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田所優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 石谷太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 井上大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 土谷佳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 大澤毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Arai Fumio 新井 文用

ARAI Fumio 新井 文用

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of hematopoietic stem cell maintenance by newly identified bone marrow mesenchymal stem cells.Principal Investigator

Principal Investigator

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Research Institution

Overcoming T cell dysfunction with Shelterin factorPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Function of telomere binding factors in normal and tumor hematopoietic microenvironments

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of transcriptional signaling networks that control the quality and quantity of the bone marrow microenvironment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the functional regulation mechanism of the hematopoietic microenvironment (niche) by the shelterin factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional elucidation of shelterin factor TIN2 in leukemic stem cells and its application to the development of novel therapeutic strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function of Foxp2 in the maintenance of hematopoietic stem cells.

Principal Investigator

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Research Institution

Elucidation of the mechanism of asymmetric division of hematopoietic stem cells using the next-generation artificial nichePrincipal Investigator

Principal Investigator

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Research Institution

Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell division

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention of age-related deregulation of hematopoietic stem cell function through the protection of telomeric DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of symmetric division-related molecules in the regulation of self-renewal of hematopoietic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Analyses of hematopoietic stem cell division patterns in biomimetic culture conditions and optimization of culture condition for hematopoietic stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

人工幹細胞ニッチ:造血ニッチ複合体の再構成による幹細胞増幅Principal Investigator

Principal Investigator

Project Period (FY)

Arai Fumio 新井文用

ARAI Fumio 新井文用