KIJIMA Takashi 木島貴志

… Alternative Names

木島貴志キジマタカシ

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Researcher Number	90372614
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 兵庫医科大学, 医学部, 教授 2017: 大阪大学, 医学系研究科, 招へい教授 2016: 大阪大学, 医学系研究科, 講師 2013 – 2015: 大阪大学, 医学(系)研究科(研究院), 講師 2012: 大阪大学, 医学(系)研究科(研究院), 助教 … More 2011: 大阪大学, 大学院・医学系研究科, 助教 2009 – 2011: Osaka University, 医学系研究科, 助教 2005 – 2006: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 90110:Biomedical engineering-related / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 52040:Radiological sciences-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Respiratory organ internal medicine
Keywords	Principal Investigator ラパチニブ / HER2 / 分子標的治療 / 多剤耐性 / 間質性肺炎 / 声門開放呼気CT / 拘束性肺疾患 / 閉塞性肺疾患 / 声門開放CT / 呼吸動態 … More / 肺コンプイアンス / 気道抵抗 / 胸腔内圧 / 食道内圧 / 口腔内圧 / 食道カテーテル / IPV / 肺コンプライアンス / 遺伝子改変マウス / signal pathway / BAP1 / トランスジェニックマウス / モデルマウス / 悪性中皮腫 / 内在性リガント / MyD88 / 腫瘍関連線維芽細胞 / 腫瘍関連マクロファージ / 無菌的炎症 / 微小環境 / Toll様受容体 / 化学療法抵抗性 / 無菌的炎症誘導 / アポトーシス小体 / 内在性リガンド / 癌微小環境 / 肺癌 / ＨＥＲ２ / ベバシズマブ / ICAM-1 / ADCC / トラスツズマブ / 小細胞肺癌 / CXCL12 / テトラスパニン / 細胞接着誘導抗癌剤耐性(CAM-DR) / ABCトランスポーター / CXCR4 / ケモカイン / 小細胞肺癌(SCLC) / CD9 / 小細胞肺がん … More Except Principal Investigator p21 / EGFR / 癌免疫療法 / I型インターフェロン / 自然免疫 / 小細胞肺癌 / 治療効果予測 / SUVmax / FDG集積 / 糖代謝 / 癌の免疫微小環境 / FDG-PET/CT / 予後予測 / 治療効果判定 / 免疫チェックポイント阻害剤 / FDG-PET / 分子標的治療 / 肺癌 / 癌微小環境 / 薬剤性肺障害 / 腫瘍関連マクロファージ / Hippoシグナル伝達系 / 薬剤性間質性肺炎 / ドライバー遺伝子変異・転座陽性肺癌 / 炎症性疾患 / 低侵襲治療 / ドラッグデリバリーシステム / 難治性癌 / 腫瘍集積性 / 肝臓集積性 / 核酸医薬 / microRNA / DDS / 癌幹細胞 / The Extracellular Domain of erbB2 / Density-dependent Inhibition of Cell Growth / Malignant Mesothelioma / erbB2細胞外ドメイン / 増殖停止機構 / 悪性胸膜中皮腫 Less

Developing a novel therapeutic strategy to overcome multidrug resistance in small-cell lung cancer by activating innate immunity
- Principal Investigator
  
  南俊行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hyogo Medical University
Treatment response and prognosis prediction of immune checkpoint inhibitors by FDG-PET/CT: A Japanese multicenter prospective study
- Principal Investigator
  
  北島一宏
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hyogo Medical University
Development of new diagnostic methods for respiratory diseases based on the mechanics of respiratory dynamicsPrincipal Investigator
- Principal Investigator
  
  Kijima Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Hyogo Medical University
Overcoming drug-induced interstital lung disease caused by molecular targeted therapy in lung cancer
- Principal Investigator
  
  Minami Toshiyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hyogo Medical University
Identification of molecular mechanism underlying malignant mesothelioma development using conditional mouse model and search of therapeutic target moleculesPrincipal Investigator
- Principal Investigator
  
  Takashi Kijima
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hyogo Medical University
Development of innovative nucleic acid medicine using EPR enhancer iNaD
- Principal Investigator
  
  Yamamoto Hirofumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka University
Developing novel lung cancer therapy targetting cancer cell intrinsic ligandsPrincipal Investigator
- Principal Investigator
  
  Kijima Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University
HER2 target therapy for multidrug-resistant small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  KIJIMA TAKASHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University
Molecular target therapy for multidrug-resistant small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  KIJIMA Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University
The Induction of Decsity-Deoendent Inhibition of Cell Growth in Malignant Mesothelioma Cells by the Extracellular Domain of erbB2 for Reduction of Growth of Mesothelioma
- Principal Investigator
  
  KUMAGAI Toru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University

All 2023 2022 2020 2019 2017 2015 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Efficacy and safety of nivolumab with ipilimumab for recurrent malignant pleural mesothelioma after primary surgical intervention2023
- Author(s)
  Nakamura Akifumi、Hashimoto Masaki、Kondo Nobuyuki、Matsumoto Seiji、Kuroda Ayumi、Minami Toshiyuki、Kitajima Kazuhiro、Kuribayashi Kozo、Kijima Takashi、Hasegawa Seiki
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 28 Issue: 3 Pages: 409-415
- DOI
  10.1007/s10147-023-02292-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08555
[Journal Article] Combination therapy with anti-programmed cell death 1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant mesothelioma via tumor microenvironment modulation2023
- Author(s)
  Tada Akio、Minami Toshiyuki、Kitai Hidemi、Higashiguchi Yoko、Tokuda Mayuko、Higashiyama Tomoki、Negi Yoshiki、Horio Daisuke、Nakajima Yasuhiro、Otsuki Taiichiro、Mikami Koji、Takahashi Ryo、Nakamura Akifumi、Kitajima Kazuhiro、Ohmuraya Masaki、Kuribayashi Kozo、Kijima Takashi
- Journal Title
  
  Lung Cancer
  
  Volume: 180 Pages: 107219-107219
- DOI
  10.1016/j.lungcan.2023.107219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08555
[Journal Article] Epigenetic Alterations and Biomarkers for Immune Checkpoint Inhibitors-Current Standards and Future Perspectives in Malignant Pleural Mesothelioma Treatment.2020
- Author(s)
  Yoshikawa Y, Kuribayashi K, Minami T, Ohmuraya M, Kijima T.
- Journal Title
  
  Front Oncol.
  
  Volume: 10 Pages: 554570-554570
- DOI
  10.3389/fonc.2020.554570
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08405, KAKENHI-PROJECT-18K07212, KAKENHI-PROJECT-18K08161
[Journal Article] Clinical utility of FDG-PET/CT for post-surgery surveillance of malignant pleural mesothelioma - Comparison with contrast-enhanced CT.2019
- Author(s)
  Kitajima K, Hashimoto M, Katsuura T, Kondo N, Minami T, Kuribayashi K, Hasegawa S, Kijima T, Yamakado K.
- Journal Title
  
  Oncotarget.
  
  Volume: 10(63) Issue: 63 Pages: 6816-6828
- DOI
  10.18632/oncotarget.27324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08161
[Journal Article] Favorable response to trastuzumab plus irinotecan combination therapy in two patients with HER2-positive relapsed small-cell lung cancer.2015
- Author(s)
  Kinehara Y, Minami T, Kijima T, Hoshino S, Morimura O, Otsuka T, Hayama Y, Fukushima K, Takeuchi Y, Higashiguchi M, Miyake K, Hirata H, Nagatomo I, Inoue K, Takeda Y, Kida H, Kumanogoh A.
- Journal Title
  
  Lung Cancer.
  
  Volume: 87 Issue: 3 Pages: 321-325
- DOI
  10.1016/j.lungcan.2015.01.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591165, KAKENHI-PROJECT-26860606
[Journal Article] Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.2013
- Author(s)
  Minami T, Kijima T, Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata H, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Issue: 1 Pages: 2669-2669
- DOI
  10.1038/srep02669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591165, KAKENHI-PUBLICLY-25133705, KAKENHI-PROJECT-25670143
[Journal Article] HER2 as therapeutic target for overcoming ATP-binding cassette transporter-mediated chemoresistance in small cell lung cancer2012
- Author(s)
  南俊行, 木島貴志, 大谷安司, 河面聡, 他
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: Vol.11(4) Pages: 830-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590993
[Journal Article] HER2 as therapeutic target for overcoming ATP-binding cassette transporter-mediated chemoresistance in small cell lung cancer.2012
- Author(s)
  Minami T, Kijima T, Otani Y, Kohmo S, Takahashi R, Nagatomo I, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 11(4) Issue: 4 Pages: 830-841
- DOI
  10.1158/1535-7163.mct-11-0884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591165
[Journal Article] Cell surface tetraspanin CD9 mediates chemo-resistance in small cell lung cancer2010
- Author(s)
  河面聡, 木島貴志, 大谷安司, 南俊行, 他
- Journal Title
  
  Cancer Research
  
  Volume: Vol.70(20) Pages: 8025-8035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590993
[Journal Article] Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer2010
- Author(s)
  河面聡, 木島貴志, 大谷安司, 南俊行, 他
- Journal Title
  
  Cancer Research
  
  Volume: VOL.70 Pages: 8025-8035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590993
[Presentation] 閉鎖式高頻度人工呼吸器を用いた非侵襲肺コンプライアンス計測の提案2023
- Author(s)
  北岡裕子，間瀬教史，木島貴志
- Organizer
  第62回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-21K12637
[Presentation] 腫瘍関連マクロファージの制御を介した悪性胸膜中皮腫に対する抗PD-1抗体と血管新生阻害薬併用療法の抗腫瘍効果2023
- Author(s)
  多田陽郎、南　俊行、北井秀美、東口洋子、村上美沙、河村直樹、藤岡　毅、近藤孝憲、森下実咲、徳田麻佑子、東山友樹、祢木芳樹、堀尾大介、大搗泰一郎、三上浩司、高橋　良、栗林康造、木島貴志
- Organizer
  第63 回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08555
[Presentation] 悪性胸膜中皮腫に対する抗PD-1抗体と血管新生阻害薬併用療法の抗腫瘍効果について2022
- Author(s)
  多田陽郎、南　俊行、森下美咲、徳田麻佑子、村上美沙、神取恭史、河村直樹、近藤孝憲、清田穣太郎、西村　駿、長野昭近、東山友樹、祢木芳樹、堀尾大介、大搗泰一郎、三上浩司、高橋　良、北島一宏、栗林康造、木島貴志
- Organizer
  第3回日本石綿・中皮腫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08555
[Presentation] Tumor suppressor BAP1 impairs the function of B cells－in vitro analysis using BAP1 knockout-B blastoid cells－2020
- Author(s)
  木村美智、多田陽郎、木島貴志、大村谷昌樹、吉川良恵
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K08161
[Presentation] 難治性癌に対する核酸医薬MIRTXの抗腫瘍効果の検討2019
- Author(s)
  五島碧, 横山雄起, 入江侑馬, 廣瀬遥香, 木島貴志, 三好康雄, 柴田理志, 山本浩文
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04059
[Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients.2017
- Author(s)
  A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
- Organizer
  World Conference on Lung Cancer, Oct 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09220
[Presentation] 分子標的治療による小細胞肺癌の抗癌剤耐性の克服2013
- Author(s)
  南　俊行、木島貴志、大谷安司
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591165
[Presentation] Molecular targeting therapy to overcome chemoresistance in small cell lung cancer2012
- Author(s)
  南俊行，木島貴志，河面聡，大谷安司，高橋良，長友泉，武田吉人，立花功，熊ノ郷淳
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  北海道札幌
- Data Source
  KAKENHI-PROJECT-24591165
[Presentation] HER2 as therapeutic target for overcoming ATP-binding cassette transporter-mediated chemoresistance in small cell lung cancer2012
- Author(s)
  南俊行，木島貴志，大谷安司，河面聡，高橋良，長友泉，平田陽彦，鈴木真優美，井上幸治，武田吉人，木田博，立花功，熊ノ郷淳
- Organizer
  第103回　AACR (Ammerican Association for Cancer Research) annual meeting
- Place of Presentation
  米国シカゴ
- Data Source
  KAKENHI-PROJECT-24591165
[Presentation] HER2陽性抗癌剤耐性小細胞肺癌におけるLapatinibのABCトランスポーター阻害効果2011
- Author(s)
  南俊行, 木島貴志, 大谷安司, 河面聡, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590993
[Presentation] 小細胞肺癌の抗癌剤耐性におけるCD9の関与と治療標的としての可能性2009
- Author(s)
  大谷安司, 河面聡, 南俊行, 木島貴志, 他
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-21590993
[Presentation] 小細胞肺癌の抗癌剤耐性におけるCD9の関与と治療標的としての可能性2009
- Author(s)
  南俊行, 木島貴志, 大谷安司, 他
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590993
[Presentation] HER2陽性再発小細胞肺癌に対するirinotecan + trastuzumab併用療法（基礎研究から臨床応用まで）
- Author(s)
  南俊行，甲原雄平，木島貴志，森村治、大塚倫之，三宅浩太郎，竹内美子、井上幸治，長友泉，木田博，熊ノ郷淳
- Organizer
  第55回日本肺癌学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-24591165
[Presentation] EphA2レセプター阻害はセネッセンス誘導を介して小細胞肺がん細胞の増殖を抑制する
- Author(s)
  森村治，木島貴志，南俊行，熊ノ郷淳
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591165
[Presentation] Targeting HER2 and VEGF stepwise can overcome multidrug resistance in small cell lung cancer.
- Author(s)
  Minami T, Kijima T, Kinehara Y, Morimura O, Higashiguchi M, Miyake K, Hirata H, Takeuchi Y, Fukushima K, Hayama Y, Inoue K, Nagatomo I, Takeda Y, Kida H, Kumanogoh A.
- Organizer
  第105回米国癌学会(AACR) 2014
- Place of Presentation
  San Diego、CA, USA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-24591165
[Presentation] Trastuzumab-based chemotherapy for HER2-positive refractory relapsed small-cell lung cancer (from bench to bed side)
- Author(s)
  甲原雄平，南俊行，木島貴志，福島清春，葉山善友，竹内美子，平田陽彦，井上幸治，熊ノ郷淳
- Organizer
  第12回日本臨床腫瘍学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2014-07-17 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-24591165

1. MINAMI Toshiyuki (00705113)

# of Collaborated Projects: 7 results

# of Collaborated Products: 21 results
2. 北島一宏 (80448860)

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# of Collaborated Products: 0 results
3. NAGATOMO Izumi (10570583)

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6. YOSHIDA Mitsuhiro (90359844)

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26. 渡部直史 (90648932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 高濱隆幸 (90716359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 武田吉人 (40452388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. OTANI Yasushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

KIJIMA Takashi 木島 貴志

木島 貴志 キジマ タカシ

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Developing a novel therapeutic strategy to overcome multidrug resistance in small-cell lung cancer by activating innate immunity

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Treatment response and prognosis prediction of immune checkpoint inhibitors by FDG-PET/CT: A Japanese multicenter prospective study

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Development of new diagnostic methods for respiratory diseases based on the mechanics of respiratory dynamicsPrincipal Investigator

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Overcoming drug-induced interstital lung disease caused by molecular targeted therapy in lung cancer

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Identification of molecular mechanism underlying malignant mesothelioma development using conditional mouse model and search of therapeutic target moleculesPrincipal Investigator

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Development of innovative nucleic acid medicine using EPR enhancer iNaD

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Developing novel lung cancer therapy targetting cancer cell intrinsic ligandsPrincipal Investigator

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HER2 target therapy for multidrug-resistant small cell lung cancerPrincipal Investigator

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Molecular target therapy for multidrug-resistant small cell lung cancerPrincipal Investigator

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The Induction of Decsity-Deoendent Inhibition of Cell Growth in Malignant Mesothelioma Cells by the Extracellular Domain of erbB2 for Reduction of Growth of Mesothelioma

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[Journal Article] Efficacy and safety of nivolumab with ipilimumab for recurrent malignant pleural mesothelioma after primary surgical intervention2023

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[Journal Article] Combination therapy with anti-programmed cell death 1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant mesothelioma via tumor microenvironment modulation2023

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[Journal Article] Epigenetic Alterations and Biomarkers for Immune Checkpoint Inhibitors-Current Standards and Future Perspectives in Malignant Pleural Mesothelioma Treatment.2020

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KIJIMA Takashi 木島貴志

木島貴志キジマタカシ