TAKAHASI Kiyohiro 高橋清大

… Alternative Names

高橋清大タカハシキヨヒロ

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Researcher Number	90399965
Other IDs
Affiliation (based on the past Project Information) *help	2014: 学習院大学, 理学部, 助教 2013: 京都大学, ウイルス研究所, 助教 2011 – 2013: 京都大学, 薬学研究科(研究院), 助教 2012: 京都大学, 大学院・薬学研究科, 特定助教 2007: 北海道大学, 大学院・薬学研究院, 博士研究員 2005: 北海道大学, 大学院・薬学研究科, 学術研究員
Review Section/Research Field	Principal Investigator Virology / Structural biochemistry Except Principal Investigator Biological Sciences / Virology
Keywords	Principal Investigator インターフェロン / RIG-I / 自然免疫 / シグナル伝達 / IPS-1 / I型インターフェロン / 構造解析 Except Principal Investigator インターフェロン / 自然免疫 / 感染症 … More / ウイルス / 免疫学 / ストレス / 二重連鎖DNA / 5'ppp-ssRNA / dsRNA / RNA結合ループ / LGP2 / MDA-5 / RIG-1 / ウイルス感染 / ウィルス / リン酸化 / 分子認識 / 蛋白質 / シグナル伝達 Less

Study of signal mechanism of viral sensor protein RIG-IPrincipal Investigator
- Principal Investigator
  
  KIYOHIRO Takahasi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Gakushuin University
  Kyoto University
Viral RNA factory formation and activation of antiviral innate immunity
- Principal Investigator
  
  FUJITA Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  Kyoto University
Functional analysis of RIG-I and its medical applicationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Kiyohiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
RIG-I、MDA-5からIRF-3に至るシグナル伝達の構造生物学
- Principal Investigator
  
  稲垣冬彦
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
インターフェロン誘導因子IRF-3の関与するシグナル伝達機構の構造生物学的研究
- Principal Investigator
  
  堀内正隆
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University

All 2014 2013 2012 2011 2008

All Journal Article Presentation Book

[Book] ナノバイオ技術と最新創薬応用研究2012
- Author(s)
  高橋清大
- Total Pages
  4
- Publisher
  自然免疫における構造 - 機能相関
- Data Source
  KAKENHI-PROJECT-23770113
[Book] 自然免疫における構造- 機能相関2012
- Author(s)
  高橋清大
- Total Pages
  4
- Publisher
  メディカルドゥ, トランスレーショナルリサーチを支援するナノバイオ技術と最新創薬応用研究
- Data Source
  KAKENHI-PROJECT-23770113
[Book] Intracellular Viral RNA Sensors: RIG.I Like Receptors in Nucleic Acid Sensors and Antiviral Immunity2011
- Author(s)
  Seiji P. Yamamoto, Ryo Narita, Seigyoku Go, Kiyohiro Takahasi, Hiroki Kato and Takashi Fujita(Ed. Suryaprakash Sambhara and Takashi Fujita)
- Data Source
  KAKENHI-PROJECT-23249023
[Journal Article] DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation2014
- Author(s)
  Yoo, J-S., Takahasi, K., Ng, CS., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J-C., Lattmann, S., Nagamine, Y., Matsui, T., Iwabuchi, K., Kato, H. Fujita, T.
- Journal Title
  
  PLoS Pathog
  
  Volume: 10(3) Issue: 3 Pages: 1-18
- DOI
  10.1371/journal.ppat.1004012
- NAID
  120005466661
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249023, KAKENHI-PROJECT-23310041, KAKENHI-PROJECT-23390108, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-24651056, KAKENHI-PUBLICLY-25115503, KAKENHI-PROJECT-26293101
[Journal Article] Functional characterization of domains of IPS-1 using an inducible oligomerization system2013
- Author(s)
  Takamatsu S,Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, Fujiwara TK, Yoneyama M, Kato H, Fujita T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1371/journal.pone.0053578
- NAID
  120005241348
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-23249023, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23890029, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115004
[Journal Article] 55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation2011
- Author(s)
  Kageyama, M., Takahasi, K., Narita, R., Hirai, R., Yoneyama, M., Kato, H., Fujita, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 415 (1) Pages: 75-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770113
[Journal Article] RIG-I-like receptors : cytoplasmic sensors for non-self RNA2011
- Author(s)
  Kato, H., Takahasi, K. and Fujita, T.
- Journal Title
  
  Immunological Reviews
  
  Volume: 243 Pages: 91-98
- NAID
  120005587805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249023
[Journal Article] Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Downregulation of the Very Low Density Lipoprotein Receptor2011
- Author(s)
  Ouda, R., Onomoto, K., Takahasi, K., Edwards, M.R., Kato, H., Yoneyama, M. and Fujita, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 26210-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249023
[Journal Article] 55 amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation2011
- Author(s)
  Kageyama M, Takahasi K, Narita R, Hirai R, Yoneyama M, Kato H, Fujita T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 415 Issue: 1 Pages: 75-81
- DOI
  10.1016/j.bbrc.2011.10.015
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23770113
[Journal Article] Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses2008
- Author(s)
  Takahasi K
- Journal Title
  
  Mol. Cell. 29
  
  Pages: 428-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041003
[Journal Article] Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses2008
- Author(s)
  Takahasi K
- Journal Title
  
  Mol. Cell 29
  
  Pages: 428-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041003
[Presentation] ウイルスセンサータンパク質RIG-Iの自己抑制ドメインの同定2012
- Author(s)
  高橋清大
- Organizer
  第３回　ナノバイオ創薬研究シンポジウム
- Place of Presentation
  京都大学(京都府)
- Data Source
  KAKENHI-PROJECT-23770113
[Presentation] ウイルス NPによる顆粒形成の機構と生理的機能の解析2012
- Author(s)
  呉成旭、尾野本浩司、高橋清大、石館文善、加藤博己、藤田尚志
- Organizer
  第77回日本インターフェロン・サイトカイン学会学術集会
- Year and Date
  2012-06-21
- Data Source
  KAKENHI-PROJECT-23249023
[Presentation] ウイルス感染における自然免疫の役割2012
- Author(s)
  高橋清大
- Organizer
  第三回革新的ナノバイオシンポジウム
- Place of Presentation
  京都大学薬学部記念講堂(京都府)
- Year and Date
  2012-03-04
- Data Source
  KAKENHI-PROJECT-23770113
[Presentation] RIG-I C末端側ドメインの機能解析2008
- Author(s)
  高橋清大
- Organizer
  科学研究費補助金「特定領域研究」感染現象のマトリックス第4回全体班会議
- Place of Presentation
  東京学術総合センター
- Data Source
  KAKENHI-PROJECT-19041003

1. FUJITA Takashi (10156870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. KATO Hiroki (10597173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 堀内正隆 (90322825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 稲垣冬彦 (70011757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ONOMOTO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 米山光俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAHASI Kiyohiro 高橋 清大

高橋 清大 タカハシ キヨヒロ

Research Projects

Research Products

Co-Researchers

Study of signal mechanism of viral sensor protein RIG-IPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Viral RNA factory formation and activation of antiviral innate immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of RIG-I and its medical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RIG-I、MDA-5からIRF-3に至るシグナル伝達の構造生物学

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インターフェロン誘導因子IRF-3の関与するシグナル伝達機構の構造生物学的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] ナノバイオ技術と最新創薬応用研究2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 自然免疫における構造- 機能相関2012

Author(s)

Total Pages

Publisher

Data Source

[Book] Intracellular Viral RNA Sensors: RIG.I Like Receptors in Nucleic Acid Sensors and Antiviral Immunity2011

Author(s)

Data Source

[Journal Article] DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Functional characterization of domains of IPS-1 using an inducible oligomerization system2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation2011

Author(s)

Journal Title

Data Source

[Journal Article] RIG-I-like receptors : cytoplasmic sensors for non-self RNA2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Downregulation of the Very Low Density Lipoprotein Receptor2011

Author(s)

Journal Title

Data Source

[Journal Article] 55 amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses2008

Author(s)

TAKAHASI Kiyohiro 高橋清大

高橋清大タカハシキヨヒロ