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Morimoto Kaori  森本 かおり

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MORIMOTO Kaori  森本 かおり

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Researcher Number 90401009
Other IDs
Affiliation (Current) 2025: 東北医科薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2025: 東北医科薬科大学, 薬学部, 講師
2018 – 2023: 東北医科薬科大学, 薬学部, 講師
2013 – 2015: 東北薬科大学, 薬学部, 講師
2014: 高崎健康福祉大学, 薬学部, 講師
2010 – 2012: 高崎健康福祉大学, 薬学部, 講師
2007 – 2008: Takasaki University of Health and Welfare, 薬学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Applied pharmacology / Medical pharmacy
Except Principal Investigator
Applied pharmacology
Keywords
Principal Investigator
トランスポーター / 消化管吸収 / ABC transporter / 小腸 / PEPT1 / 相互作用 / 局在 / OATP / がん多剤耐性克服 / DDS … More / 多剤耐性克服 / Drug delivery system / EPR効果 / デキストラン / transporter / Dextran / ABCトランスポーター / 多剤耐性 / 薬物送達システム / デキストラン誘導体 / Indoxyl Sulfate / 消化管分泌 / インドキシル硫酸 / 尿毒症 / 腎不全 / 消化管 / 消化管吸 / 臨床試験 / ミルク / PEPT-1 / 薬物-食物間相互作用 / 薬物相互作用 / 医薬品副作用 / P-糖蛋白質 / P-糖タンパク質 / 血液脳関門 / オセルタミビル … More
Except Principal Investigator
脳保護作用 / シルニジピン / 脳組織移行性 / トランスポーター / 消化管吸収 / ラディキシン / 輸送活性 / 正常組織 / がん細胞 / 排出組織 / 多剤耐性 / radixin / 組織選択性 / ERMタンパク / 調節因子 / 膜上発現 / 裏打ちタンパク / がん多剤耐性 / P-糖タンパク Less
  • Research Projects

    (7 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (9 People)
  •  有機アニオン薬物の消化管上皮細胞への取り込み輸送体は何か―OATP4A1の可能性―Principal Investigator

    • Principal Investigator
      森本 かおり
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  小腸に発現する機能未知OATPトランスポーターの薬物吸収における役割の解明Principal Investigator

    • Principal Investigator
      森本 かおり
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  Development of cancer-specific drug carriers possessing comprehensive inhibitory effect of ABC transportersPrincipal Investigator

    • Principal Investigator
      Morimoto Kaori
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney diseasePrincipal Investigator

    • Principal Investigator
      MORIMOTO Kaori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku Pharmaceutical University
  •  The construction of a means to overcome cancerous multidrug resistance by mediating the post-translational regulators of drug-efflux transporters

    • Principal Investigator
      OGIHARA Takuo
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Takasaki University of Health and Welfare
  •  Effect of Food on the Intestinal PEPT1-mediated Drug AbsorptionPrincipal Investigator

    • Principal Investigator
      MORIMOTO Kaori
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Takasaki University of Health and Welfare
  •  The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivirPrincipal Investigator

    • Principal Investigator
      MORIMOTO Kaori
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Takasaki University of Health and Welfare

All 2021 2018 2015 2014 2013 2012 2011 2008 2007 Other

All Journal Article Presentation Book

  • [Book] トランスポーター科学最前線2008

    • Author(s)
      荻原琢男、森本かおり
    • Publisher
      京都廣川書店
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Book] 創薬支援研究の展望2008

    • Author(s)
      荻原琢男、森本かおり、玉井郁巳
    • Publisher
      株式会社シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Journal Article] Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter2021

    • Author(s)
      Morimoto Kaori、Sasaki Momona、Oikawa Erika、Abe Maho、Kikuchi Tatsuro、Ishii Makoto、Ogihara Takuo、Tomita Mikio
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 44 Issue: 5 Pages: 653-658

    • DOI

      10.1248/bpb.b20-00947

    • NAID

      130008033241

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2021-05-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06692
  • [Journal Article] Multiple linear regression analysis indicates association of P-glycoprotein substrate or inhibitor character with bitterness intensity, measured with a sensor2015

    • Author(s)
      Kentaro Yano, Suzune Mita, Kaori Morimoto, Tamami Haraguchi, Hiroshi Arakawa, Miyako Yoshida, Fumiyoshi Yamashita, Takahiro Uchida, Takuo Ogihara
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 104 Issue: 9 Pages: 2789-2794

    • DOI

      10.1002/jps.24232

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102, KAKENHI-PROJECT-24590667, KAKENHI-PROJECT-25670073
  • [Journal Article] Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo2013

    • Author(s)
      Yano K, Tomono T, Sakai R, Kano T, Morimoto K, Kato Y, Ogihara T.
    • Journal Title

      J Pharm Sci.

      Volume: 102(8) Issue: 8 Pages: 2875-81

    • DOI

      10.1002/jps.23637

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590667
  • [Journal Article] 消化管吸収過程におけるペプチドトランスポーター・PEPT1 を介した薬物-食物間相互作用の解析2013

    • Author(s)
      森本かおり
    • Journal Title

      薬学研究の進歩 研究成果報告集

      Volume: 29巻 Pages: 87-91

    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] The Role of Inter-segmental Differences in P-glycoprotein expression and activityalong the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration2013

    • Author(s)
      Wada S, Kano T, Mita S, Idota Y, Morimoto K, Yamashita F, Ogihara T.
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: Vo.28 Pages: 98-103

    • URL

      https://www.jstage.jst.go.jp/article/dmpk/28/2/28_DMPK-12-RG-005/_article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] The Role of Inter-segmental Differences in P-glycoprotein Expression and Activity along the Rat Small Intestine in Causing the Double-peak Phenomenon of Substrate Plasma Concentration2013

    • Author(s)
      Sho Wada, Takashi Kano,Suzune Mita, Yoko Idota, Kaori Morimoto, Fumiyoshi Yamashita, Takuo Ogihara
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 28 Issue: 2 Pages: 98-103

    • DOI

      10.2133/dmpk.DMPK-12-RG-005

    • NAID

      130004933523

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590667, KAKENHI-PLANNED-23136102
  • [Journal Article] 消化管吸収過程におけるペプチドトランスポーター・PEPT1を介した薬物-食物間相互作用の解析2013

    • Author(s)
      森本かおり
    • Journal Title

      薬学研究の進歩

      Volume: 29 Pages: 87-91

    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] The role of inter-segmental differences in P-glycoprotein expression and activity along the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration2013

    • Author(s)
      S. Wada, T. Kano, S. Mita, Y. Idota, K. Morimoto, F. Yamashita, T. Ogihara
    • Journal Title

      Drug Metab.Pharmacokinet .

      Volume: 28 Pages: 98-103

    • NAID

      130004933523

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590667
  • [Journal Article] 有機アニオントランスポーターの遺伝子多型による前立腺がんの再燃予測2012

    • Author(s)
      森本かおり
    • Journal Title

      ファルマシア

      Volume: Vol.48 Pages: 556-556

    • NAID

      110009885212

    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats2012

    • Author(s)
      Morimoto K, Nagami T, Matsumoto N, Wada S, Kano T, Kakinuma, Ogihara T
    • Journal Title

      J Toxicol Sci

      Volume: Vol.37 Pages: 1217-1223

    • NAID

      10031126025

    • URL

      https://www.jstage.jst.go.jp/article/jts/37/6/37_1217/_pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] Transport mechanism of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes2012

    • Author(s)
      Kobayashi S, Nagai T, Konishi Y, Tanabe S, Morimoto K, Ogihara T
    • Journal Title

      J Pharm Pharmacol

      Volume: Vol.61 Issue: 1 Pages: 52-60

    • DOI

      10.1111/j.2042-7158.2011.01374.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats.2012

    • Author(s)
      Kaori Morimoto
    • Journal Title

      J Toxicol Sci.

      Volume: 37 Pages: 1217-1223

    • NAID

      10031126025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers2011

    • Author(s)
      Morimoto K, Kishimura K, Nagami T, Kodama N, Ogama Y, Yokoyama M, Toda S, Chiyoda T, Shimada R, Inano A, Kano T, Tamai I, Ogihara T
    • Journal Title

      J. Pharm. Sci

      Volume: Vol.100 Issue: 9 Pages: 3854-3861

    • DOI

      10.1002/jps.22627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers2011

    • Author(s)
      Kaori Morimoto
    • Journal Title

      J. Pharm. Sci

      Volume: 100 Pages: 3854-3861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] 食品成分と薬物の相互作用2011

    • Author(s)
      小林彰子, 森本かおり, 荻原琢男
    • Journal Title

      BIOINDUSTRY

      Volume: 28巻 Pages: 30-35

    • URL

      http://www.fujisan.co.jp/product/1281680662/b/691304/

    • Data Source
      KAKENHI-PROJECT-22590505
  • [Journal Article] Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-glycoprotein.2008

    • Author(s)
      Morimoto K, Nakakariya M, Shirasaka Y, Kakinuma C, Fujita T, Tamai I, Ogihara T.
    • Journal Title

      Drug Metab Dispos 36

      Pages: 6-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Journal Article] Oseltamivir (Tamiful) efflux transport at the Blood-Brain Barrier by P-glycoprotein2008

    • Author(s)
      Kaori Morimoto, et. al.
    • Journal Title

      Drug Metabolism and Disposition 36

      Pages: 6-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Journal Article] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.

    • Author(s)
      Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I.
    • Journal Title

      Drug Metab Dispos in press

      Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Presentation] Dextranによる多剤耐性関連輸送体の阻害効果2021

    • Author(s)
      森本かおり, 石井 敬, 杉本 芳一, 荻原 琢男, 富田 幹雄
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K06790
  • [Presentation] Dextranによる多剤耐性関連輸送体の阻害効果2021

    • Author(s)
      森本かおり、石井敬、杉本芳一、荻原琢男、富田幹雄
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K06790
  • [Presentation] Cationic modification gives dextran a BCRP inhibitory effect2021

    • Author(s)
      森本かおり, 石井 敬, 杉本 芳一, 荻原 琢男, 富田 幹雄
    • Organizer
      日本薬物動態学会第36回年会
    • Data Source
      KAKENHI-PROJECT-18K06790
  • [Presentation] Dextranによる複数のABC transporterの同時阻害2018

    • Author(s)
      石井敬、森本かおり、熊谷茉歩、富田幹雄
    • Organizer
      第57回日本薬学会東北支部会
    • Data Source
      KAKENHI-PROJECT-18K06790
  • [Presentation] 尿毒症物質インドキシル硫酸の消化管分泌機構の解析2015

    • Author(s)
      富永雄太、森本かおり、宮本将成、柏倉正太、高橋昂、佐野芳美、矢野健太郎、荻原琢男、富田幹雄
    • Organizer
      日本薬物動態学会第30年会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-25460196
  • [Presentation] 今から始める腎臓病薬物療法シリーズ:仙台版「よくわかる尿毒症」2015

    • Author(s)
      森本かおり
    • Organizer
      第9回日本腎臓病薬物療法学会学術集会・総会2015
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-10-24
    • Data Source
      KAKENHI-PROJECT-25460196
  • [Presentation] インドキシル硫酸の代償性排泄経路としての消化管分泌の関与2015

    • Author(s)
      富永雄太、森本かおり、宮本将成、柏倉正太、高橋昂、佐野芳美、矢野健太郎、荻原琢男、富田幹雄
    • Organizer
      第9回日本腎臓病薬物療法学会学術集会・総会2015
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-10-24
    • Data Source
      KAKENHI-PROJECT-25460196
  • [Presentation] 尿毒症物質インドキシル硫酸の消化管粘膜透過機構の解析2014

    • Author(s)
      宮本将成、我妻雄太、野呂悠佳、森本かおり、矢野健太郎、荻原拓男、富田幹雄.
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき明星大学(福島県いわき市)
    • Year and Date
      2014-10-05
    • Data Source
      KAKENHI-PROJECT-25460196
  • [Presentation] Contribution of radixin to P-glycoprotein expression and transport activity2013

    • Author(s)
      Yano K, Tomono T, Kawabata H, Idota Y, Morimoto K, Arakawa H, Ogihara T
    • Organizer
      28th JSSX Annual Meeting,
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-24590667
  • [Presentation] Contribution of radixin in segmental difference of P-glycoprotein expression in small intestine2012

    • Author(s)
      伴野 拓巳、酒井 理予、矢野 健太郎、叶 隆、森本 かおり、加藤 将夫、荻原 琢男
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉(タワーホール船堀)
    • Data Source
      KAKENHI-PROJECT-24590667
  • [Presentation] Radixin is involved in P-glycoprotein expression in small intestine2012

    • Author(s)
      酒井 理予、叶 隆、和田 翔、森本 かおり、荻原 琢男
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸(神戸国際会議場)
    • Data Source
      KAKENHI-PROJECT-24590667
  • [Presentation] Interaction of milk with the intestinal PEPT1-mediated absorption of oseltamivir in rats and humans2011

    • Author(s)
      Kaori Morimoto
    • Organizer
      17^NORTH AMERICAN MEETING OF ISSX
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Presentation] Interaction of milk with the intestinal PEPT1-mediated absorption of oseltamivir in rats and humans.2011

    • Author(s)
      Kaori Morimoto
    • Organizer
      17^<th> NORTH AMERICAN MEETING OF lSSX
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22590505
  • [Presentation] Controlled Brain Exposure of Oseltamivir by Drug Transporters2008

    • Author(s)
      Kaori Morimoto, et al.
    • Organizer
      2^<nd> Asian Pacific Regional ISSX Meeting
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2008-05-13
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Presentation] Controlled Brain Exposure of Oseltamivir by Drug Transporters. 2^<nd> Asia Pacific Regional ISSX Meeting.2008

    • Author(s)
      Morimoto K, et al.
    • Organizer
      2^<nd> Asia Pacific Regional ISSX Meeting
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2008-05-13
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Presentation] Oseltamivir (Tamiful) efflux transport at the Blood-Brain Barrier by P-glycoprotein2007

    • Author(s)
      Kaori Morimoto, et. al.
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-27
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Presentation] Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-glycoprotein2007

    • Author(s)
      Morimoto K, et al.
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-27
    • Data Source
      KAKENHI-PROJECT-19599023
  • [Presentation] 尿毒症物質によるMRP2ならびにBCRPの阻害

    • Author(s)
      我妻雄太、飯田 遼、森本かおり、富田幹雄.
    • Organizer
      日本薬剤学会29年会
    • Place of Presentation
      大宮ソニックホール(埼玉県大宮市)
    • Year and Date
      2014-05-20 – 2014-05-22
    • Data Source
      KAKENHI-PROJECT-25460196
  • [Presentation] P-glycoprotein Plays a Key Role in the Contractionary Effects against Brain Infarction of

    • Author(s)
      Takumi Tomono, Kentaro Yano, Toshimitsu Motegi, Shinobu Takimoto, Mihoko Hagiwara, Yoko Idota, Takashi Kano, Hiroshi Arakawa, Kaori Morimoto, Chihaya Kakinuma, Akira Takahara, Takuo Ogihara
    • Organizer
      19th North American ISSX/29th JSSX Meeting
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-24590667
  • 1.  OGIHARA Takuo (80448886)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 21 results
  • 2.  IDOTA Yoko (90629594)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 3.  KENTARO Yano (40644290)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 4.  TAMAI Ikumi (20155237)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 5.  石井 敬 (00735714)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 6.  KANO Takashi (70509257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  MASAHIRO Kajita (40591871)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TOMITA Mikio (60207610)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  山下 富義
    # of Collaborated Projects: 0 results
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