ISHII Takeo 石井健男

Researcher Number	90445750
Affiliation (based on the past Project Information) *help	2016 – 2023: 日本医科大学, 大学院医学研究科, 研究生 2011 – 2015: 日本医科大学, 医学部, 講師 2007 – 2010: Nippon Medical School, 医学部, 助教
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 病態関連遺伝子 / 遺伝子多型 / 増悪 / 慢性閉塞性肺疾患 / 遺伝子多型（SNP） / 遺伝子多型（SNP) / バイオマーカー / 遺伝子多型　（SNP) / gap junction / 増悪（exacerbation） … More / COPD / 慢性炎症 / 自然免疫 / NODs / オートファジー / 鬱症状 / 肥満 / 睡眠時無呼吸症候群 / 肺高血圧 / セロトニン代謝関連遺伝子 / 欝症状 … More Except Principal Investigator 肺気腫 / LTBP4 / 慢性閉塞性肺疾患 / COPD / 遺伝子多型 / 心筋障害 / 臨床呼吸器学 / 内科系臨床医学 / 運動耐容能 / 心筋傷害 / 心血管併存症 / NT-proBNP / 高感度トロポニンT / ガレクチン-3 / エクソソーム / cutis laxa / exosome / ヒト肺線維芽細胞 / エラスチン / LTBP-4 / 動脈瘤 / アンギオテンシン / TGF-beta / 細胞外基質 (ECM) / Marfan症候群 / マルファン症候群 / ECM / 肺線維症 / 肺癌 / ニコチン受容体 / 喫煙 / 閉塞性肺疾患 Less

Cutis laxa類似病態の肺気腫：エクソソームによる診断とLTBP4補充療法
- Principal Investigator
  
  木田厚瑞
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Exploring the role of galectin-3 to elucidate the new mechanism of organ correlation between lung and heart in COPD
- Principal Investigator
  
  Hiramatsu Kumiko
- Project Period (FY)
  2016 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Pathogenesis of COPD exacerbation and the proteins related to gap junctionPrincipal Investigator
- Principal Investigator
  
  Ishii Takeo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Investigation on pathogenesis and therapy of COPD with phenotypes of Marfan syndrome, especially on its relation to ECM malformation
- Principal Investigator
  
  Kida Kozui
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Investigation on pathogenesis of COPD exacerbations through autophagyPrincipal Investigator
- Principal Investigator
  
  ISHII Takeo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
The association between genetic variations of the neuronal nicotinic cholinergic receptors and smoking-related lung diseases
- Principal Investigator
  
  KIDA Kozui
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Search on genes related to depressive symptoms in COPDPrincipal Investigator
- Principal Investigator
  
  ISHII Takeo
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School

All 2017 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.2017
- Author(s)
  Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Pare PD, Lomas DA, Silverman EK, Taniguchi N, Kida K
- Journal Title
  
  Respirology
  
  Volume: 22 Issue: 4 Pages: 684-690
- DOI
  10.1111/resp.12952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-16K09559, KAKENHI-PROJECT-15H04700
[Journal Article] Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms.2010
- Author(s)
  Ishii T, et al.
- Journal Title
  
  Journal of Human Genetics. 56
  
  Pages: 41-46
- NAID
  10030657316
- Data Source
  KAKENHI-PROJECT-19790570
[Journal Article] Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms.2010
- Author(s)
  Ishii T, et al.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 56 Pages: 41-46
- NAID
  10030657316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] Association between emphysema and genetic variations of CHRNA32011
- Author(s)
  Takeo Ishii, Kozui Kida 他
- Organizer
  American Thoracic Society 2011 International Conference
- Place of Presentation
  デンバー(アメリカ)
- Data Source
  KAKENHI-PROJECT-22590845
[Presentation] Association between emphysema and genetic variations of CHRNA32011
- Author(s)
  Takeo Ishii, Kozui Kida, 他
- Organizer
  American Thoracic Society 2011 International Conference
- Place of Presentation
  デンバー(アメリカ)
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22590845
[Presentation] Serotonin transporter遺伝子とうつ合併の気道病変型COPDとの関連2010
- Author(s)
  石井健男, 他
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都(日本)
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] COPDのgeneticsとphenotypes.2010
- Author(s)
  石井健男, 他
- Organizer
  第2回呼吸機能イメージング研究会
- Place of Presentation
  沖縄
- Year and Date
  2010-01-30
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] Serotonin transporter 遺伝子とうつ合併の気道病変型COPDとの関連2010
- Author(s)
  石井健男, 他
- Organizer
  第50回日本呼吸器学会総会
- Place of Presentation
  京都
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] COPDのgeneticsとphenotypes2010
- Author(s)
  石井健男, 他
- Organizer
  第2回呼吸機能イメージング研究会
- Place of Presentation
  沖縄
- Year and Date
  2010-01-30
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] Association of serotonin transporter gene variation with smoking, COPD and its depressive symptoms.2010
- Author(s)
  Takeo ISHII, et al.
- Organizer
  ATS[American Thoracic Society]2010
- Place of Presentation
  ニューオリンズ(アメリカ)
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] Association of serotonin transporter gene variation with smoking, COPD, and its depressive symptoms.2010
- Author(s)
  石井健男, 他
- Organizer
  ATS [American Thoracic Society] 2009.
- Place of Presentation
  ニューオリンズ(アメリカ)
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] 慢性閉塞性肺疾患における鬱症状規定因子の検討及びQOLとの関係2009
- Author(s)
  石井健男, 他
- Organizer
  第49回日本呼吸器学会総会
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] 慢性閉塞性肺疾患における欝症状規定因子の検討2008
- Author(s)
  石井健男, 他
- Organizer
  日本呼吸器学会総会
- Place of Presentation
  神戸
- Year and Date
  2008-06-17
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] The factors reLated to depressive symptoms in chronic obs tructive pulmonary disease.2008
- Author(s)
  石井健男, 他
- Organizer
  ATS [Am erican Thoracic Society] 2008
- Place of Presentation
  トロント(カナダ)
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] The factors related to depressive symptoms in chronic obstruct lye oulmonary disease2008
- Author(s)
  石井健男、他
- Organizer
  ATS [American Thoracic Society]2008
- Place of Presentation
  トロント(カナダ)
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] 慢性閉塞性肺疾患における鬱症状規定因子の検討2008
- Author(s)
  石井健男, 他
- Organizer
  日本呼吸器学会総会
- Place of Presentation
  神戸
- Year and Date
  2008-06-17
- Data Source
  KAKENHI-PROJECT-19790570
[Presentation] The factors related to depressive symptoms in chronic obstructive pulmonary disease.2008
- Author(s)
  石井健男, 他
- Organizer
  ATS [American Thoracic Society] 2008.
- Place of Presentation
  トロント(カナダ)
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19790570

1. ARAI Tomio (20232019)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. KIDA Kozui (90142645)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. Betsuyaku Tomoko (60333605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 神尾孝一郎 (20465305)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MURAMATSU Masaaki (50230008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAWABE Motoji (30196331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIENO Makiko (60464707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IKEDA Shinobu (20415508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HAGIWARA Koichi (00240705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Hiramatsu Kumiko (40409173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 辻隆夫 (30459664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石井正紀 (20724438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 宮武佳子 (10267213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OHTSUBO Kazuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHII Takeo 石井 健男

Research Projects

Research Products

Co-Researchers

Cutis laxa類似病態の肺気腫：エクソソームによる診断とLTBP4補充療法

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring the role of galectin-3 to elucidate the new mechanism of organ correlation between lung and heart in COPD

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis of COPD exacerbation and the proteins related to gap junctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on pathogenesis and therapy of COPD with phenotypes of Marfan syndrome, especially on its relation to ECM malformation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on pathogenesis of COPD exacerbations through autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The association between genetic variations of the neuronal nicotinic cholinergic receptors and smoking-related lung diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search on genes related to depressive symptoms in COPDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms.2010

Author(s)

Journal Title

NAID

Data Source

[Presentation] Association between emphysema and genetic variations of CHRNA32011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Association between emphysema and genetic variations of CHRNA32011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Serotonin transporter遺伝子とうつ合併の気道病変型COPDとの関連2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] COPDのgeneticsとphenotypes.2010

Author(s)

ISHII Takeo 石井健男