Oto Umeharu 大戸梅治

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OHTO Umeharu 大戸梅治

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Researcher Number	90451856
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院新領域創成科学研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2017: 東京大学, 大学院薬学系研究科, 准教授 2016: 東京大学, 薬学研究科(研究院), 准教授 2013 – 2015: 東京大学, 薬学研究科(研究院), 講師 2013: 東京大学, 薬学研究科, 助教 … More 2011 – 2012: 東京大学, 大学院・薬学系研究科, 助教 2011 – 2012: 東京大学, 薬学研究科(研究院), 助教 2011: 東京大学, 薬学研究科, 助教 2010: 東京大学, 薬学研究所, 助教 2009: 東京大学, 薬学研究科, 助教 2007 – 2008: The University of Tokyo, 大学院・薬学系研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Biological Sciences / Transformative Research Areas, Section (III) / Complex systems / Functional biochemistry / Structural biochemistry / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Physical pharmacy Except Principal Investigator Collagenous pathology/Allergology / Physical pharmacy / Biological Sciences
Keywords	Principal Investigator 自然免疫 / 構造生物学 / Ｘ線結晶構造解析 / クライオ電子顕微鏡 / シグナル伝達 / 膜受容体 / TLR受容体 / 結晶構造解析 / 一回膜貫通型受容体 / ダイオキシン … More / タンパク質 / 炎症 / NLR / インフラマソーム / チオレドキシン / トランスポーター / 胆汁酸 / HBV / NTCP / B型肝炎 / COVID-19 / 新型コロナウイルス / ウイルス感染 / グリッド / 気液界面 / アモルファス / PEG化修飾 / 化学修飾 / 構造解析 / ナノディスク / Ｘ線結晶解析 / 環境ホルモン / Nod様受容体 / Toll様受容体 / 芳香族炭化水素受容体 / 環境汚染 / ウイルス / X線結晶構造解析 / 受容体 / リポ多糖 / エンドトキシン … More Except Principal Investigator 自然免疫 / 創薬 / 天然薬物 / TLR7 / 全身性エリテマトーデス / バイオテクノロジー / シグナル伝達 / 薬学 / 生体分子 / 沈降速度法 / 超遠心分析 / TNF / 免疫複合体 / 抗体 / 立体構造 / 質量分析 / 凝集体 / 蛋白質 / バイオ医薬品 / 分析 / 免疫原性 / 界面 / タンパク質 / 凝集 / 安定性 / 抗体医薬 / バイオ医薬 / 病原体センサー / 病源体センサー / 自然得免疫 / Toll様受容体 Less

ウイルス感染機構解明および感染制御法開発を目指した構造生物学研究Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
非典型的細胞内核酸センサ―を介した自然免疫応答の構造科学的解明Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
バイオロジカルクラスターを介した免疫機構およびその制御法の解明Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Elucidation of regulation mechanism of the NLR inflammasome by the thioredoxin systemPrincipal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Structural biology aiming regulation of viral infectionPrincipal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Improving particle behaviors for cryo-EM analysis by PEGylationPrincipal Investigator
- Principal Investigator
  
  Umeharu Ohto
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
一回膜貫通型受容体のシグナル伝達の構造基盤Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Elucidation of a complete picture of the activation mechanism of Toll-like receptors in lipid bilayers by multilevel analysisPrincipal Investigator
- Principal Investigator
  
  Ohto Umeharu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
リポクオリティとTLR活性化機構の解析Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
一回膜貫通型受容体のシグナル伝達の構造基盤Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Physico-chemical and mathematical analyses of immune related signal induced by antibody aggregates
- Principal Investigator
  
  Uchiyama Susumu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
The development of therapeutic agents for SLE based on inhibition of innate immune receptor TLR7
- Principal Investigator
  
  OKAMOTO Naoki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  University of Toyama
Structural elucidation of dioxin recognition by aryl hydrocarbon receptorPrincipal Investigator
- Principal Investigator
  
  Ohto Umeharu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
Structural basis for innate immune pathogen sensorsPrincipal Investigator
- Principal Investigator
  
  Ohto Umeharu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
宿主細胞によるウイルス由来RNA認識の構造生物学的研究Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
自然免疫系受容体による病原体認識機構の解明Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural biology of dioxin receptorPrincipal Investigator
- Principal Investigator
  
  OHTO Umeharu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
自然免疫系受容体によるリガンド認識とシグナル伝達の構造的基盤Principal Investigator
- Principal Investigator
  
  大戸梅治
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural analyses of nucleic acid sensing TLR receptorsPrincipal Investigator
- Principal Investigator
  
  OHTO Umeharu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Toll like receptors; their endogenous ligands and mechanism regulating their activities
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural biology of MD-2 and TLR4 protein toward a therapeutic drug for sepsisPrincipal Investigator
- Principal Investigator
  
  OHTO Umeharu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo

[Journal Article] Structural basis of hepatitis B virus receptor binding2024
- Author(s)
  Asami Jinta、Park Jae-Hyun、Nomura Yayoi、Kobayashi Chisa、Mifune Junki、Ishimoto Naito、Uemura Tomoko、Liu Kehong、Sato Yumi、Zhang Zhikuan、Muramatsu Masamichi、Wakita Takaji、Drew David、Iwata So、Shimizu Toshiyuki、Watashi Koichi、Park Sam-Yong、Nomura Norimichi、Ohto Umeharu
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 31 Issue: 3 Pages: 447-454
- DOI
  10.1038/s41594-023-01191-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19447, KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-22K15046, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K24142, KAKENHI-PROJECT-23K27415
[Journal Article] TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction2023
- Author(s)
  Sakaniwa Kentaro、Fujimura Akiko、Shibata Takuma、Shigematsu Hideki、Ekimoto Toru、Yamamoto Masaki、Ikeguchi Mitsunori、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 164-164
- DOI
  10.1038/s41467-023-35844-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366
[Journal Article] Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway2023
- Author(s)
  Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Arashiki N, Nakamura F, Nishikawa K, Maru Y.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: - Issue: 7 Pages: 1-12
- DOI
  10.1038/s41417-023-00604-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820
[Journal Article] Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome2023
- Author(s)
  Zhang Zhikuan、Shibata Takuma、Fujimura Akiko、Kitaura Jiro、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature
  
  Volume: 622 Issue: 7981 Pages: 188-194
- DOI
  10.1038/s41586-023-06532-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-22K15046, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27637
[Journal Article] TLR7/8 stress response drives histiocytosis in SLC29A3 disorders2023
- Author(s)
  Shibata Takuma、Sato Ryota、Taoka Masato、Saitoh Shin-Ichiroh、Komine Mayumi、（他16人）、Ohto Umeharu、Shimizu Toshiyuki、Ozawa Manabu、Yoshida Nobuaki、Isobe Toshiaki、Latz Eicke、Mukai Kojiro、Taguchi Tomohiko、Hemmi Hiroaki、Akira Shizuo、Miyake Kensuke
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 9 Pages: 320230054-320230054
- DOI
  10.1084/jem.20230054
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27084, KAKENHI-PROJECT-23K27637
[Journal Article] Propofol directly binds to and inhibits <scp>TLR7</scp>2022
- Author(s)
  Koutsogiannaki Sophia、Bu Weiming、Maisat Wiriya、Manzor Mariel、Zhang Zhikuan、Ohto Umeharu、Eckenhoff Roderic G.、Yuki Koichi
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 8
- DOI
  10.1096/fj.202200312r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820
[Journal Article] Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation2022
- Author(s)
  Ohto Umeharu、Kamitsukasa Yukie、Ishida Hanako、Zhang Zhikuan、Murakami Karin、Hirama Chie、Maekawa Sakiko、Shimizu Toshiyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 11
- DOI
  10.1073/pnas.2121353119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-21K19207
[Journal Article] Structure of the?bile acid transporter?and HBV receptor NTCP2022
- Author(s)
  Asami Jinta、Kimura Kanako Terakado、Fujita-Fujiharu Yoko、Ishida Hanako、Zhang Zhikuan、Nomura Yayoi、Liu Kehong、Uemura Tomoko、Sato Yumi、Ono Masatsugu、Yamamoto Masaki、Noda Takeshi、Shigematsu Hideki、Drew David、Iwata So、Shimizu Toshiyuki、Nomura Norimichi、Ohto Umeharu
- Journal Title
  
  Nature
  
  Volume: 606 Issue: 7916 Pages: 1021-1026
- DOI
  10.1038/s41586-022-04845-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21J12207, KAKENHI-PROJECT-22J14378, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820, KAKENHI-PLANNED-19H05777
[Journal Article] Activation and regulation mechanisms of NOD-like receptors based on structural biology2022
- Author(s)
  Ohto Umeharu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 953530-953530
- DOI
  10.3389/fimmu.2022.953530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820
[Journal Article] Structure of SARS-CoV-2 membrane protein essential for virus assembly2022
- Author(s)
  Zhang Zhikuan、Nomura Norimichi、Muramoto Yukiko、Ekimoto Toru、Uemura Tomoko、Liu Kehong、Yui Moeko、Kono Nozomu、Aoki Junken、Ikeguchi Mitsunori、Noda Takeshi、Iwata So、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4399-4399
- DOI
  10.1038/s41467-022-32019-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07086, KAKENHI-PROJECT-21K19327, KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21K19207, KAKENHI-PLANNED-18H05426, KAKENHI-PUBLICLY-21H00228, KAKENHI-PROJECT-23K23820, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-20H03380
[Journal Article] The structure of NLRP9 reveals a unique C‐terminal region with putative regulatory function2022
- Author(s)
  Kamitsukasa Yukie、Nakano Kenji、Murakami Karin、Hirata Kunio、Yamamoto Masaki、Shimizu Toshiyuki、Ohto Umeharu
- Journal Title
  
  FEBS Letters
  
  Volume: 596 Issue: 7 Pages: 876-885
- DOI
  10.1002/1873-3468.14302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-21K19207
[Journal Article] Cryo-EM structures of Toll-like receptors in complex with UNC93B12021
- Author(s)
  Ishida Hanako、Asami Jinta、Zhang Zhikuan、Nishizawa Tomohiro、Shigematsu Hideki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 28 Issue: 2 Pages: 173-180
- DOI
  10.1038/s41594-020-00542-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-20K16274, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H00976
[Journal Article] Improving particle quality in cryo-EM analysis using a PEGylation method2021
- Author(s)
  Zhang Zhikuan、Shigematsu Hideki、Shimizu Toshiyuki、Ohto Umeharu
- Journal Title
  
  Structure
  
  Volume: 29 Issue: 10 Pages: 1192-1199.e4
- DOI
  10.1016/j.str.2021.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-21K19328
[Journal Article] Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists2021
- Author(s)
  Yang Yi、Csakai Adam、Jiang Shuangshuang、Smith Christina、Tanji Hiromi、Huang Jian、Jones Torey、Sakaniwa Kentaro、Broadwell Lindsey、Shi Chengrui、Soti Subada、Ohto Umeharu、Fang Yaohui、Shen Shu、Deng Fei、Shimizu Toshiyuki、Yin Hang
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4351-4351
- DOI
  10.1038/s41467-021-24536-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19J21830, KAKENHI-PROJECT-21K19207
[Journal Article] Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity2020
- Author(s)
  Kanoh Hirotaka、Nitta Takahiro、Go Shinji、Inamori Kei‐ichiro、Veillon Lucas、Nihei Wataru、Fujii Mayu、Kabayama Kazuya、Shimoyama Atsushi、Fukase Koichi、Zonca Asia、Cattaneo Anna、Letizia Marilena、Ciampa Maria、Mauri Laura、Prinetti Alessandro、Sonnino Sandro、Suzuki Akemi、Inokuchi Jin‐ichi et. al.
- Journal Title
  
  The EMBO Journal
  
  Volume: － Issue: 12 Pages: 1-20
- DOI
  10.15252/embj.2019101732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04620, KAKENHI-PUBLICLY-18H04669, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-17K15450, KAKENHI-PROJECT-18K05356, KAKENHI-PROJECT-18K06662, KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-19K16356, KAKENHI-PROJECT-20K15412, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-20H00404, KAKENHI-PROJECT-20H03452, KAKENHI-PROJECT-19K23627, KAKENHI-PROJECT-19KK0145
[Journal Article] Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases2020
- Author(s)
  Sakurai Shunya、Shimizu Toshiyuki、Ohto Umeharu
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 76 Issue: 8 Pages: 326-333
- DOI
  10.1107/s2053230x20009012
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164
[Journal Article] Structural analysis reveals TLR7 dynamics underlying antagonism2020
- Author(s)
  Tojo Shingo、Zhang Zhikuan、Matsui Hiroyuki、Tahara Masahiro、Ikeguchi Mitsunori、Kochi Mami、Kamada Mami、Shigematsu Hideki、Tsutsumi Akihisa、Adachi Naruhiko、Shibata Takuma、Yamamoto Masaki、Kikkawa Masahide、Senda Toshiya、Isobe Yoshiaki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-020-19025-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19H03197, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H03451
[Journal Article] Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains2020
- Author(s)
  Masutani Mamiko、Sakurai Shunya、Shimizu Toshiyuki、Ohto Umeharu
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 18 Pages: 3020-3031
- DOI
  10.1002/1873-3468.13875
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164
[Journal Article] The effect of anesthetics on toll like receptor 92020
- Author(s)
  Koutsogiannaki Sophia、Bu Weiming、Hou Lifei、Shibamura‐Fujiogi Miho、Ishida Hanako、Ohto Umeharu、Eckenhoff Roderic G.、Yuki Koichi
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 11 Pages: 14645-14654
- DOI
  10.1096/fj.202000791rr
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164
[Journal Article] Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface2020
- Author(s)
  Jiang Shuangshuang、Tanji Hiromi、Yin Kejun、Zhang Shuting、Sakaniwa Kentaro、Huang Jian、Yang Yi、Li Jing、Ohto Umeharu、Shimizu Toshiyuki、Yin Hang
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 63 Issue: 8 Pages: 4117-4132
- DOI
  10.1021/acs.jmedchem.9b02128
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04669, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19J21830
[Journal Article] Quantitative Laser Diffraction for Quantification of Protein Aggregates: Comparison With Resonant Mass Measurement, Nanoparticle Tracking Analysis, Flow Imaging, and Light Obscuration2019
- Author(s)
  Yoneda Saki、Niederleitner Bertram、Wiggenhorn Michael、Koga Hiroki、Totoki Shinichiro、Krayukhina Elena、Friess Wolfgang、Uchiyama Susumu
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 108 Issue: 1 Pages: 755-762
- DOI
  10.1016/j.xphs.2018.09.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03975
[Journal Article] Mechanisms controlling nucleic acid-sensing Toll-like receptors2018
- Author(s)
  Miyake Kensuke、Shibata Takuma、Ohto Umeharu、Shimizu Toshiyuki、Saitoh Shin-Ichiroh、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 2 Pages: 43-51
- DOI
  10.1093/intimm/dxy016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16K08827
[Journal Article] Structural basis for species-specific activation of mouse Toll-like receptor 92018
- Author(s)
  Ishida Hanako、Ohto Umeharu、Shibata Takuma、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 15 Pages: 2636-2646
- DOI
  10.1002/1873-3468.13176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Physicochemical improvement of rabbit derived single-domain antibodies by substitutions with amino acids conserved in camelid antibodies2018
- Author(s)
  Shinozaki Naoya、Hashimoto Ryuji、Noda Masanori、Uchiyama Susumu
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 125 Issue: 6 Pages: 654-661
- DOI
  10.1016/j.jbiosc.2018.01.006
- NAID
  210000005719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03975
[Journal Article] Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation2018
- Author(s)
  Ohto Umeharu、Ishida Hanako、Shibata Takuma、Sato Ryota、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 4 Pages: 649-658
- DOI
  10.1016/j.immuni.2018.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga2018
- Author(s)
  Xu Yuqun、Miyakawa Takuya、Nosaki Shohei、Nakamura Akira、Lyu Ying、Nakamura Hidemitsu、Ohto Umeharu、Ishida Hanako、Shimizu Toshiyuki、Asami Tadao、Tanokura Masaru
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 3947-3947
- DOI
  10.1038/s41467-018-06452-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05453, KAKENHI-PUBLICLY-17H05835, KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04608, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-18H05266
[Journal Article] Small-Molecule TLR8 Antagonists via Structure-Based Rational Design2018
- Author(s)
  Hu Zhenyi、Tanji Hiromi、Jiang Shuangshuang、Zhang Shuting、Koo Kyoin、Chan Jean、Sakaniwa Kentaro、Ohto Umeharu、Candia Albert、Shimizu Toshiyuki、Yin Hang
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 25 Issue: 10 Pages: 1286-1291
- DOI
  10.1016/j.chembiol.2018.07.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494
[Journal Article] Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands2018
- Author(s)
  Zhang Zhikuan、Ohto Umeharu、Shibata Takuma、Taoka Masato、Yamauchi Yoshio、Sato Ryota、Shukla Nikunj M.、David Sunil A.、Isobe Toshiaki、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  Cell Reports
  
  Volume: 25 Issue: 12 Pages: 3371-3381
- DOI
  10.1016/j.celrep.2018.11.081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-18J14570, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Small-molecule inhibition of TLR8 through stabilization of its resting state2018
- Author(s)
  Zhang, S., Hu, Z., Tanji, H., Jiang, S., Das, N, Li, J., Sakaniwa, K., Jin, J., Bian, Y., Ohto, U., Shimizu, T., Yin, H.
- Journal Title
  
  Nature Chem. Biol.
  
  Volume: 14 Issue: 1 Pages: 58-64
- DOI
  10.1038/nchembio.2518
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485
[Journal Article] The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif.2017
- Author(s)
  Sakurai S, Tomita T, Shimizu T, Ohto U
- Journal Title
  
  Acta Crystallographica Section F
  
  Volume: 73 Issue: 3 Pages: 130-137
- DOI
  10.1107/s2053230x17001911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471
[Journal Article] Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids2017
- Author(s)
  Miyake K, Shibata T, Ohto U, Shimizu T
- Journal Title
  
  J Leukoc Biol
  
  Volume: 101 Issue: 1 Pages: 135-142
- DOI
  10.1189/jlb.4mr0316-108r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16K08827
[Journal Article] Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex2017
- Author(s)
  Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 37 Pages: 15378-15394
- DOI
  10.1074/jbc.m117.791780
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19532, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-17H02207, KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K19596, KAKENHI-PROJECT-15K09491
[Journal Article] Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities2017
- Author(s)
  Shinozaki Naoya、Hashimoto Ryuji、Fukui Kiichi、Uchiyama Susumu
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 5794-5794
- DOI
  10.1038/s41598-017-06277-x
- NAID
  120006995024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03975
[Journal Article] The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription2017
- Author(s)
  Sakurai, S., Shimizu, T., & *Ohto, U.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 43 Pages: 17609-17616
- DOI
  10.1074/jbc.m117.812974
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17J10586
[Journal Article] Towards a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system2017
- Author(s)
  Zhang, Z., Ohto, U., & Shimizu, T.
- Journal Title
  
  FEBS letters.
  
  Volume: 591 Issue: 20 Pages: 3167-3181
- DOI
  10.1002/1873-3468.12749
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Journal Article] The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.2017
- Author(s)
  Murakami, K., Nakano, K., Shimizu, T., & *Ohto, U.
- Journal Title
  
  Acta Crystallogr F Struct Biol Commun.
  
  Volume: 73 Issue: 6 Pages: 347-355
- DOI
  10.1107/s2053230x17007336
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Journal Article] Conservation and Divergence of Ligand Recognition and Signal Transduction Mechanisms in Toll-Like Receptors2017
- Author(s)
  Ohto, U.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 65 Issue: 8 Pages: 697-705
- DOI
  10.1248/cpb.c17-00323
- NAID
  130005875868
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Journal Article] Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.2016
- Author(s)
  Beesu, M., Caruso, G., Salyer, A. C., Shukla, N. M., Khetani, K. K., Smith, L. J., Fox, L. M., Tanji, H., Ohto, U., Shimizu, T., & David, S. A.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 59 Issue: 7 Pages: 3311-3330
- DOI
  10.1021/acs.jmedchem.6b00023
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H02494
[Journal Article] Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.2016
- Author(s)
  Tanji, H., Ohto, U., Motoi, Y., Shibata, T., Miyake, K., & Shimizu, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A
  
  Volume: 113 Issue: 11 Pages: 3012-3017
- DOI
  10.1073/pnas.1516000113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-16K08827
[Journal Article] Crystal structure of NOD2 and its implications in human disease.2016
- Author(s)
  Maekawa S, Ohto U, Shibata T, Miyake K, Shimizu T
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 11813-11813
- DOI
  10.1038/ncomms11813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471
[Journal Article] Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.2016
- Author(s)
  Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T.
- Journal Title
  
  Nature
  
  Volume: 534 Issue: 7608 Pages: 566-569
- DOI
  10.1038/nature18596
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291052, KAKENHI-PROJECT-26711002
[Journal Article] Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.2016
- Author(s)
  Deguchi A, Tomita T, Ohto U, Takemura K, Kitao A, Akashi-Takamura, S, Miyake K, and Maru Y.
- Journal Title
  
  Oncogene
  
  Volume: 35 Issue: 11 Pages: 1445-1456
- DOI
  10.1038/onc.2015.211
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06842, KAKENHI-PROJECT-26440063, KAKENHI-PROJECT-15K14471, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-15H04357, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K09491
[Journal Article] Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA2016
- Author(s)
  Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K, Shimizu T
- Journal Title
  
  Immunity
  
  Volume: 45 Issue: 4 Pages: 737-748
- DOI
  10.1016/j.immuni.2016.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16K08827
[Journal Article] Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity.2015
- Author(s)
  Beesu, M., Caruso, G., Salyer, A., Khetani, K., Sil, D., Weerasinghe, M., Tanji, H., Ohto, U., Shimizu, T., & David, S. A.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 58 Issue: 19 Pages: 7833-7849
- DOI
  10.1021/acs.jmedchem.5b01087
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-26711002
[Journal Article] Structure of human Roquin-2 and its complex with constitutive-decay element RNA.2015
- Author(s)
  Sakurai, S., Ohto, U., & Shimizu, T.
- Journal Title
  
  Acta Crystallogr. Sect. F
  
  Volume: 71 Issue: 8 Pages: 1048-1054
- DOI
  10.1107/s2053230x15011887
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PLANNED-23116007, KAKENHI-PROJECT-26711002
[Journal Article] Toll-like receptor 8 senses degradation products of single-stranded RNA.2015
- Author(s)
  Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K,
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 22 Issue: 2 Pages: 109-115
- DOI
  10.1038/nsmb.2943
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-15J12485
[Journal Article] The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.2015
- Author(s)
  Ganapathi, L., Van Haren, S., Dowling, D. J., Bergelson, I., Shukla, N. M., Malladi, S. S., Balakrishna, R., Tanji, H., Ohto, U., Shimizu, T., David, S. A., & Levy, O.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 8 Pages: 0134640-0134640
- DOI
  10.1371/journal.pone.0134640
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-26711002
[Journal Article] Structural basis of pharmacological chaperoning for human β-galactosidase2014
- Author(s)
  Suzuki H, et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 21 Pages: 14560-14568
- DOI
  10.1074/jbc.m113.529529
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25293230, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26461525, KAKENHI-PROJECT-26711002
[Journal Article] Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists.2014
- Author(s)
  Kokatla, H. P., Sil, D., Tanji, H., Ohto, U., Malladi, S. S., Fox, L. M., Shimizu, T., & David, S. A.
- Journal Title
  
  ChemMedChem.
  
  Volume: 9 Issue: 4 Pages: 713-723
- DOI
  10.1002/cmdc.201300573
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25650029
[Journal Article] Structure and function of toll-like receptor 8.2014
- Author(s)
  Ohto, U., Tanji, H., & Shimizu, T.
- Journal Title
  
  Microbes Infect.
  
  Volume: 16 Issue: 4 Pages: 273-282
- DOI
  10.1016/j.micinf.2014.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029
[Journal Article] Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity2014
- Author(s)
  Yoo E, Salunke DB, Sil D, Guo X, Salyer AC, Hermanson AR, Kumar M,
- Journal Title
  
  J Med Chem.
  
  Volume: 57 Issue: 19 Pages: 7955-7970
- DOI
  10.1021/jm500744f
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26711002
[Journal Article] TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide in vascular endothelial cells.2013
- Author(s)
  Kondo, Y., Tokuda, N., Nishitani, C., Ohto, U., Akashi-TakKondo, Y., Tokuda, N., Nishitani, C., Ohto, U., Akashi-Takamura, S., Ito, Y., Uchikawa, M., Kuroki, Y., Miyake, K., Zhang, Q., Furukawa, K., Furukawa, K
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110 Issue: 12 Pages: 4714-4719
- DOI
  10.1073/pnas.1218508110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23110008, KAKENHI-PROJECT-23590371, KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-23659171, KAKENHI-PROJECT-23770106, KAKENHI-PROJECT-24390078, KAKENHI-PROJECT-24619007, KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-23121510
[Journal Article] TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide.2013
- Author(s)
  Kondo, Y., Ikeda, K., Tokuda, N.,Nishitani, C., Ohto, U., Akashi-Takamura, S., Ito, Y., Uchikawa, M., Kuroki, Y.,Taguchi, R., Miyake, K., Zhang, Q., Furukawa, K., and Furukawa, K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 110 Pages: 4714-4719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands2013
- Author(s)
  Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T
- Journal Title
  
  Science
  
  Volume: 339 Issue: 6126 Pages: 1426-1429
- DOI
  10.1126/science.1229159
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23770106, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25291010, KAKENHI-PUBLICLY-23121510
[Journal Article] Impaired α-TTP-PIPs interaction underlies familial vitamin E deficiency2013
- Author(s)
  Kono N, Ohto U, Hiramatsu T, Urabe M, Uchida Y, Satow Y, Arai H.
- Journal Title
  
  Science
  
  Volume: 340 Issue: 6136 Pages: 1106
- DOI
  10.1126/science.1233508
- NAID
  110009807290
- URL
  https://pure.teikyo.jp/en/publications/56b7af37-eea2-40be-b3c8-ab2816dab44c
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23227004, KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25460060, KAKENHI-PROJECT-25650029
[Journal Article] The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of TLR4/MD2 complex at the plasma membrane2013
- Author(s)
  Tanimura N, Saitoh S, Ohto U, Akashi-Takamura A, Fujimoto Y, Fukase K, Shimizu T, Miyake K
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Issue: 6 Pages: 307-314
- DOI
  10.1093/intimm/dxt071
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A2013
- Author(s)
  Yamakawa N, Ohto U, Akashi-Takamura S, Takahashi K, Saitoh SI, Tanimura N, Suganami T, Ogawa Y, Shibata T, Shimizu T, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 25 Pages: 45-52
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Impaired α-TTP-PIPs Interaction Underlies Familial Vitamin E Deficiency.2013
- Author(s)
  Kono, N., Ohto, U., Hiramatsu, T., Urabe, M., Uchida, Y., Satow, Y., and Arai, H.
- Journal Title
  
  Science
  
  Volume: 340 Pages: 1106-1110
- NAID
  110009807290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Serum Amyroid A3 binds MD-2 to activates p38 and NF-kB pathway in a MyD88-dependent manner2013
- Author(s)
  Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y
- Journal Title
  
  J Immunol
  
  Volume: 191(4) Issue: 4 Pages: 1856-1864
- DOI
  10.4049/jimmunol.1201996
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25650029
[Journal Article] Structural reorganization of the Toll-like receptor8 dimer induced by agonistic ligands.2013
- Author(s)
  Tanji H., Ohto U., Shibata T., Miyake M., and Shimizu T.
- Journal Title
  
  Science
  
  Volume: 339 Pages: 1426-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A2013
- Author(s)
  N. Yamakawa, U. Ohto, S. Akashi-Takamura, K. Takahashi, SI. Saitoh, N. Tanimura, T. Suganami, Y. Ogawa, T. Shibata, T. Shimizu, K. Miyake
- Journal Title
  
  Int. Immunol.
  
  Volume: 25 Issue: 1 Pages: 45-52
- DOI
  10.1093/intimm/dxs084
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-23770106, KAKENHI-PROJECT-25291010, KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-23121510, KAKENHI-PUBLICLY-24117706
[Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid2013
- Author(s)
  Yamakawa N., Ohto U., Akashi-Takamura S., Takahashi K., Saitoh S., Tanimura N., Suganami T., Ogawa Y., Shibata T., Shimizu T., and Miyake K.
- Journal Title
  
  A. Int. Immunol.
  
  Volume: 25 Pages: 45-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013
- Author(s)
  Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
- Journal Title
  
  Nat. Commun.
  
  Volume: 4 Issue: 1 Pages: 1949-1949
- DOI
  10.1038/ncomms2949
- NAID
  120005359107
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-25860353
[Journal Article] Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-22012
- Author(s)
  Ohto U, Fukase K, Miyake K, Shimizu T
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 109 Issue: 19 Pages: 7421-7426
- DOI
  10.1073/pnas.1201193109
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23121510
[Journal Article] Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus.2012
- Author(s)
  Doronin K.
- Journal Title
  
  Science.
  
  Volume: 6108 Issue: 6108 Pages: 795-8
- DOI
  10.1126/science.1226625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-23770106, KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-23121510
[Journal Article] Crystal Structure of Human β-Galactosidase: The Structural Basis of GM1 Gangliosidosis and Morquio B Diseases2012
- Author(s)
  Ohto U, et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 287 Issue: 3 Pages: 1801-1812
- DOI
  10.1074/jbc.m111.293795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045, KAKENHI-PUBLICLY-23121510, KAKENHI-PROJECT-23770106
[Journal Article] Structural analyses of human TLR4 polymorphism D299G and T399I.2012
- Author(s)
  Ohto, U., Yamakawa, N., Akashi-Takamura, S., Miyake, K., & Shimizu, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 40611-40617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Structural basis of species-specific endotoxin sensing by TLR4/MD-2.2012
- Author(s)
  Ohto, U., Fukase, K., Miyake, K., & Shimizu, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 109 Pages: 7421-7426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Coagulation factor X activates innate immunity to human species C adenovirus.2012
- Author(s)
  Doronin, K., Flatt, J. W., Di Paolo, N. C., Khare, R., Kalyuzhniy, O., Acchione, M.,Sumida, J. P., Ohto, U., Shimizu, T., Akashi-Takamura, S., Miyake, K., MacDonald, J. W., Mammler, T. K., Beyer, R. P., Farin, F. M., Stewart, P. L., Shayakhmetov, D. M.
- Journal Title
  
  Science
  
  Volume: 338 Pages: 795-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human β-galactosidase2012
- Author(s)
  Usui, K., Ohto, U., Ochi, T., Shimizu, T., Satow, Y.
- Journal Title
  
  Acta Crystallogr.Sect.F
  
  Volume: 68 Issue: 1 Pages: 73-77
- DOI
  10.1107/s1744309111047920
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23121510, KAKENHI-PROJECT-23770106
[Journal Article] Crystal Structure of Human β-Galactosidase: STRUCTURAL BASIS OF GM1GANGLIOSIDOSIS AND MORQUIO B DISEASES.2012
- Author(s)
  Ohto, U., Usui, K., Ochi, T., Yuki, K., Satow, Y., & Shimizu, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 1801-1812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Saturated Fatty Acid and TLR Signaling Link βCell Dysfunction and Islet Inflammation.2012
- Author(s)
  Eguchi, K., Manabe, I., Oishi-Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi,N., Ohto, U., Kimoto, M., Miyake, K., Tobe, K., Arai, H., Kadowaki, T., & Nagai, R.
- Journal Title
  
  Cell Metab.
  
  Volume: 15 Pages: 1-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.2012
- Author(s)
  Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
- Journal Title
  
  Cell Metab.
  
  Volume: 15 Issue: 4 Pages: 518-533
- DOI
  10.1016/j.cmet.2012.01.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PUBLICLY-22117504, KAKENHI-PROJECT-22229006, KAKENHI-PROJECT-22790691, KAKENHI-PUBLICLY-23113707, KAKENHI-PUBLICLY-23121510, KAKENHI-PROJECT-23227004, KAKENHI-PROJECT-23770106, KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-24117703
[Journal Article] Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human β-galactosidase.2012
- Author(s)
  Usui, K., Ohto, U., Ochi, T., Shimizu, T.,& Satow, Y.
- Journal Title
  
  Acta Crystallogr. Sect.
  
  Volume: F68 Pages: 73-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Structural analyses of human Toll-like receptor polymorphisms D299G and T399I2012
- Author(s)
  Ohto U, Yamakawa N, Akashi-Takamura S, Miyake K, Shimizu T
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 48 Pages: 40611-40617
- DOI
  10.1074/jbc.m112.404608
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-22370045, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-23121510
[Journal Article] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 24 Issue: 10 Pages: 613-623
- DOI
  10.1093/intimm/dxs068
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23790526, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-24790463
[Journal Article] Novel dimer organization of the TLR family as revealed by the crystal structures of mouse and human RP105/MD-1 complex2011
- Author(s)
  Ohto U, Miyake K, Shimizu T
- Journal Title
  
  J.Mol.Biol.
  
  Volume: 413 Issue: 4 Pages: 815-825
- DOI
  10.1016/j.jmb.2011.09.020
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23121510
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9-trafficking2011
- Author(s)
  Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K
- Journal Title
  
  Immunity
  
  Volume: 35 Pages: 69-81
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes2011
- Author(s)
  Shibata T, Motoi Y, Tanimura N, Yamakawa N, Akashi-Takamura S, Miyake, K
- Journal Title
  
  Int.Immunol.
  
  Volume: 23 Issue: 8 Pages: 503-510
- DOI
  10.1093/intimm/dxr044
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-22117505, KAKENHI-PROJECT-23590564
[Journal Article] Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.2011
- Author(s)
  Ohto, U., Miyake, K., & Shimizu, T.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 413 Pages: 815-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770106
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking2011
- Author(s)
  Fukui R
- Journal Title
  
  Immunity
  
  Volume: 35 Issue: 1 Pages: 69-81
- DOI
  10.1016/j.immuni.2011.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059010, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-21390298, KAKENHI-PROJECT-22500286, KAKENHI-PROJECT-22659097, KAKENHI-PROJECT-22790454, KAKENHI-PUBLICLY-23118520
[Journal Article] Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity2010
- Author(s)
  Harada, H., Ohto, U., Satow, Y.
- Journal Title
  
  J.Mol.Biol.
  
  Volume: 400 Pages: 838-846
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, and Miyake K
- Journal Title
  
  J. Exp. Med.
  
  Volume: 206 Pages: 1339-1350
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing.2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, Miyake K.
- Journal Title
  
  J.Exp.Med
  
  Volume: 206 Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Crystal twinning of human MD-2 protein recognizing endotoxin cores of lipopolysaccharide2008
- Author(s)
  Ohto, U. and Satow, Y.
- Journal Title
  
  J. Synchrotron. Radiat 15
  
  Pages: 262-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890048
[Journal Article] Crystal twinning of human MD-2 protein recognizing endotoxin cores of lipopo lysaccharide2008
- Author(s)
  Ohto, U. and Satow, Y.
- Journal Title
  
  J. Synchrotron. Radiat. 15
  
  Pages: 262-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890048
[Journal Article] Crystal structures of human MD-2 and its complex with antiendotoxic lipid Iva2007
- Author(s)
  Ohto, U., Fukase, K., Miyake, K., and Satow,Y
- Journal Title
  
  Science 316
  
  Pages: 1632-1634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890048
[Journal Article] Crystal structures of human MD-2 and its complex with antiendotoxiclipid IVa2007
- Author(s)
  Ohto, U., Fukase, K., Miyake, K., and Satow, Y.
- Journal Title
  
  Science 316
  
  Pages: 1632-1634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890048
[Presentation] 自然免疫系Toll様受容体のリガンド認識と活性化機構2023
- Author(s)
  大戸梅治
- Organizer
  第42回日本認知症学会学術集会（奈良）
- Invited
- Data Source
  KAKENHI-PROJECT-23K23820
[Presentation] 胆汁酸輸送体NTCPを介したB型肝炎ウイルス侵入の構造基盤2023
- Author(s)
  大戸梅治
- Organizer
  第96回日本生化学会大会（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-23K23820
[Presentation] B型肝炎ウイルスの受容体の立体構造とウイルス感染機構2023
- Author(s)
  大戸梅治
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K23820
[Presentation] 胆汁酸輸送体NTCPを介したB型肝炎ウイルス侵入の構造基盤2023
- Author(s)
  大戸梅治
- Organizer
  第96回日本生化学会大会（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-23K18211
[Presentation] B型肝炎ウイルスの受容体の立体構造とウイルス感染機構2023
- Author(s)
  大戸梅治
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19207
[Presentation] 自然免疫系Toll様受容体のリガンド認識と活性化機構2023
- Author(s)
  大戸梅治
- Organizer
  第42回日本認知症学会学術集会（奈良）
- Invited
- Data Source
  KAKENHI-PROJECT-23K18211
[Presentation] UNC93B1による核酸認識TLRの輸送機構の構造基盤2021
- Author(s)
  石田英子、浅見仁太、大戸梅治、清水敏之
- Organizer
  日本薬学会第141年会（広島）オンライン
- Data Source
  KAKENHI-PROJECT-19H03164
[Presentation] UNC93B1による核酸認識TLRの輸送機構の構造基盤2021
- Author(s)
  石田英子、浅見仁太、大戸梅治、清水敏之
- Organizer
  日本薬学会第141年会（広島）オンライン
- Data Source
  KAKENHI-PUBLICLY-19H04950
[Presentation] 一回膜貫通型Toll様受容体のリガンド認識とシグナル伝達機構の構造基盤2019
- Author(s)
  大戸梅治
- Organizer
  第19回日本蛋白質科学会第71回日本細胞生物学会合同年次大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04950
[Presentation] 一回膜貫通型Toll様受容体のリガンド認識とシグナル伝達機構の構造基盤2019
- Author(s)
  大戸梅治
- Organizer
  第19回日本蛋白質科学会第71回日本細胞生物学会合同年次大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] 自然免疫を担う病原体センサー蛋白質の構造基盤の解明と創薬展開2019
- Author(s)
  大戸梅治、清水敏之
- Organizer
  日本薬学会　第139年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] ZOO systemを用いた自動回折データ収集の実際2019
- Author(s)
  大戸梅治
- Organizer
  第11回SPring-8ユーザー共同体(SPRUC)放射光構造生物学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03164
[Presentation] ZOO systemを用いた自動回折データ収集の実際2019
- Author(s)
  大戸梅治
- Organizer
  第11回SPring-8ユーザー共同体(SPRUC)放射光構造生物学研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] 一回膜貫通型Toll様受容体のリガンド認識とシグナル伝達機構の構造基盤2019
- Author(s)
  大戸梅治
- Organizer
  第19回日本蛋白質科学会第71回日本細胞生物学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03164
[Presentation] ZOO systemを用いた自動回折データ収集の実際2019
- Author(s)
  大戸梅治
- Organizer
  第11回SPring-8ユーザー共同体(SPRUC)放射光構造生物学研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04950
[Presentation] 自然免疫を担う病原体センサー蛋白質の構造基盤の解明と創薬展開2019
- Author(s)
  大戸梅治、清水敏之
- Organizer
  日本薬学会　第139年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] Structural biology of Toll-like receptors2018
- Author(s)
  Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  第56回日本生物物理学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] AhRR-ARNTヘテロダイマーによるAhRの転写抑制機構の構造基盤2018
- Author(s)
  櫻井駿也、清水敏之、大戸梅治
- Organizer
  2017年度量子ビームサイエンスフェスタ
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] LIGAND RECOGNITION MECHANISM OF TLR7 REVEALED BY A LARGE-SCALE CRYSTALLOGRAPHIC STUDY2018
- Author(s)
  Z. Zhang, U. Ohto, T.Shibata, R.Sato, K.Miyake, T. Shimizu
- Organizer
  Toll meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] AhRR-ARNTヘテロダイマーによるAhRの転写抑制機構の構造基盤2018
- Author(s)
  櫻井駿也、清水敏之、大戸梅治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] The simultaneous binding of two DNA motifs for efficient activation of TLR9 revealed by X-ray Crystallography2018
- Author(s)
  U. Ohto, H. Ishida., T.Shibata, R.Sato, K.Miyake, T. Shimizu
- Organizer
  Toll meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] The simultaneous binding of two DNA motifs for efficient activation of TLR9 revealed by X-ray Crystallography2018
- Author(s)
  Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  Toll meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] 自然免疫受容体TLR9活性化機構の構造生物学的研究2018
- Author(s)
  石田英子，大戸梅治，柴田琢磨，佐藤亮太，三宅健介，清水敏之
- Organizer
  日本結晶学会平成30年度年会
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] 自然免疫受容体TLR9活性化機構の構造生物学的研究2018
- Author(s)
  石田英子，大戸梅治，柴田琢磨，佐藤亮太，三宅健介，清水敏之
- Organizer
  日本結晶学会平成30年度年会
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] LIGAND RECOGNITION MECHANISM OF TLR7 REVEALED BY A LARGE-SCALE CRYSTALLOGRAPHIC STUDY2018
- Author(s)
  Z. Zhang, U. Ohto, T.Shibata, R.Sato, K.Miyake, T. Shimizu
- Organizer
  Toll meeting 2018
- Data Source
  KAKENHI-PUBLICLY-18H04669
[Presentation] Structural biology of Toll-like receptors2018
- Author(s)
  Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  第56回日本生物物理学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] Aryl hydrocarbon receptorの機能発現機構解明に向けた構造生物学的研究2017
- Author(s)
  櫻井駿也、大戸梅治、清水敏之
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] Structural analysis reveals ligand recognition mechanism of Toll-like receptor 72017
- Author(s)
  Zhikuan Zhang, Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] Strcutrual studies of Toll-like receptor 72017
- Author(s)
  Zhikuan Zhang, Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  The 67th Annual Meeting of the American Crystallographic Association (ACA 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] Crystal structure of the autoinhibited form of NOD22017
- Author(s)
  Umeharu Ohto, Sakiko Maekawa, Toshiyuki Shimizu
- Organizer
  The 67th Annual Meeting of the American Crystallographic Association (ACA 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] sor (AhRR)によるAhRの転写抑制機構の構造基盤解明2017
- Author(s)
  櫻井駿也、清水敏之、大戸梅治
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] The crystal structure of AhRR/ARNT complex2017
- Author(s)
  Shunya Sakurai, Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  24th Congress and General Assembly of the International Union of Crystallography
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] 自然免疫Toll様受容体のリガンド認識および活性化機構2017
- Author(s)
  大戸梅治
- Organizer
  第61回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] Funiculosin variants and their synthetic derivatives are novel agonists for murine and human TLR4/MD-2 complex: Potential reagents for developing vaccine adjuvants2017
- Author(s)
  Nagai Y, Okamoto N, Takatsu K
- Organizer
  Basel Life 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19596
[Presentation] Sperm-egg interaction revealed by the structure of IZUMO1-JUNO complex2017
- Author(s)
  Umeharu Ohto
- Organizer
  American Society for Reproductive Medicine (ASRM) 2017 Scientific Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991
[Presentation] 自然免疫受容体 TLR7 の構造学的研究2016
- Author(s)
  張志寛、大戸梅治、清水敏之
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡、博多）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] Structures of nucleic acids sensing Toll-like receptors2016
- Author(s)
  Umeharu Ohto and Toshiyuki Shimizu
- Organizer
  The 45th annual meeting of the Japanese Society for Immunology (JSI)
- Place of Presentation
  沖縄コンベンションセンター（沖縄、宜野湾）
- Year and Date
  2016-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Structures of nucleic acids sensing Toll-like receptors2016
- Author(s)
  Umeharu Ohto and Toshiyuki Shimizu
- Organizer
  The 45th annual meeting of the Japanese Society for　Immunology (JSI)（
- Place of Presentation
  沖縄コンベンションセンター（沖縄、宜野湾）
- Year and Date
  2016-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] 自然免疫受容体 TLR7 の構造学的研究2016
- Author(s)
  張志寛、大戸梅治、清水敏之
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡、博多）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Structural studies of innate immune RNA receptor human TLR82016
- Author(s)
  Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  14th Conference of the Asian Crystallographic　Association
- Place of Presentation
  Hanoi, Vietnam
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] Structural studies of innate immune RNA receptor human TLR82016
- Author(s)
  Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  14th Conference of the Asian Crystallographic Association
- Place of Presentation
  Hanoi, Vietnam
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Ligand recognition and signal transduction by Toll-like receptor2015
- Author(s)
  Umeharu Ohto
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学（金沢）
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] Structural studies of single-stranded RNA receptor TLR82015
- Author(s)
  Hiromi Tanji, Umeharu Ohto, Takuma Shibaga, Kensuke Miyake, Toshiyuki Shimizu
- Organizer
  Toll meeting 2015
- Place of Presentation
  Marbella, Spain
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] mRNA分解に関与するタンパク質Roquin-2とRNA複合体のX線結晶構造解析2015
- Author(s)
  櫻井駿也、大戸梅治、清水敏之
- Organizer
  平成27年度日本結晶学会
- Place of Presentation
  大阪府立大学（大阪）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Crystallographic analyses of Toll-like receptor 9 recognizing CpG DNA2015
- Author(s)
  U. Ohto, T. Shibata, H. Tanji, H. Ishida, E. Krayukhina, S. Uchiyama, K. Miyake, and T. Shimizu
- Organizer
  Toll meeting 2015
- Place of Presentation
  Marbella, Spain
- Year and Date
  2015-09-30
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] 自然免疫受容体NOD2の構造学的研究2015
- Author(s)
  前川早貴子、大戸梅治、清水敏之
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] 核酸認識Toll様受容体によるリガンド認識とシグナル伝達の構造基盤2015
- Author(s)
  大戸梅治、清水敏之
- Organizer
  BMB2015 第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] Crystallographic analyses of Toll-like receptor 9 recognizing CpG DNA2015
- Author(s)
  U. Ohto, T. Shibata, H. Tanji, H. Ishida, E. Krayukhina, S. Uchiyama, K. Miyake, and T. Shimizu
- Organizer
  Toll meeting 2015
- Place of Presentation
  Marbella, Spain
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] 自然免疫系一本鎖RNA受容体TLR8の構造基盤2015
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邉俊明、三宅健介、清水敏之
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] mRNA分解に関与するタンパク質Roquin-2とRNA複合体のX線結晶構造解析2015
- Author(s)
  櫻井駿也、大戸梅治、清水敏之
- Organizer
  平成27年度日本結晶学会
- Place of Presentation
  大阪府立大学（大阪）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] 核酸認識Toll様受容体によるリガンド認識とシグナル伝達の構造基盤2015
- Author(s)
  大戸梅治、清水敏之
- Organizer
  BMB2015 第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Structural studies of single-stranded RNA receptor TLR82015
- Author(s)
  Hiromi Tanji, Umeharu Ohto, Takuma Shibaga, Kensuke Miyake, Toshiyuki Shimizu
- Organizer
  Toll meeting 2015
- Place of Presentation
  Marbella, Spain
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471
[Presentation] 自然免疫受容体NOD2の構造学的研究2015
- Author(s)
  前川早貴子、大戸梅治、清水敏之
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Ligand recognition and signal transduction by Toll-like receptor2015
- Author(s)
  Umeharu Ohto
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学（金沢）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] 自然免疫系一本鎖RNA受容体TLR8の構造基盤2015
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邉俊明、三宅健介、清水敏之
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] 病原体由来RNAを認識する自然免疫系TLR8の結晶構造2013
- Author(s)
  大戸梅治, 丹治裕美, 柴田琢磨, 三宅健介, 清水敏之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-23121510
[Presentation] Structural basis for species-specific endotoxin recognition by TLR4/MD-22013
- Author(s)
  U. Ohto, K. Fukase, K. Miyake, and T. Shimizu
- Organizer
  ICSG2013-SLS
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] Structural basis for species-specific endotoxin recognition by TLR4/MD-22013
- Author(s)
  U. Ohto, K. Fukase, K. Miyake, and T. Shimizu
- Organizer
  ICSG2013-SLS
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] Structural basis for species-specific endotoxin recognition by TLR4/MD-22013
- Author(s)
  U. Ohto, K. Fukase, K. Miyake, and T. Shimizu
- Organizer
  ICSG2013-SLS
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] 病原体由来RNAを認識する自然免疫系TLR8の結晶構造2013
- Author(s)
  大戸梅治,丹治裕美,柴田琢磨,三宅健介,清水敏之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] Crystal structures of human Toll-like receptor 82013
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  4th International Symposium on Diffraction Structural Biology 2013
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] Crystal structures of human Toll-like receptor 82013
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  4th International Symposium on Diffraction Structural Biology 2013
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] 自然免疫系RNA認識受容体TLR8の結晶構造2013
- Author(s)
  大戸梅治、丹治裕美、柴田琢磨、三宅健介、清水敏之
- Organizer
  第22回東京免疫フォーラム
- Place of Presentation
  東京
- Year and Date
  2013-03-14
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] Crystal structures of human Toll-like receptor 82013
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  4th International Symposium on Diffraction Structural Biology 2013
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] 4本鎖lipidAによる種特異的TLR4/MD-2活性化機構の構造基盤2012
- Author(s)
  大戸梅治,深瀬浩一,三宅健介,清水敏之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] 自然免疫系RP105/MD-1複合体の構造解析2012
- Author(s)
  大戸梅治, 三宅健介, 清水敏之
- Organizer
  日本薬学会132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PUBLICLY-23121510
[Presentation] 4本鎖lipid Aによる種特異的TLR4/MD-2活性化機構の構造基盤2012
- Author(s)
  大戸梅治, 深瀬浩一，三宅健介，清水敏之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  博多
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PUBLICLY-23121510
[Presentation] Structural basis of species-specific endotoxin sensing by TLR4/MD-22012
- Author(s)
  Umeharu Ohto
- Organizer
  Program for Young Researcher Symposium in Europe
- Place of Presentation
  Cambridge, UK
- Year and Date
  2012-06-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-23121510
[Presentation] Structural basis of species-specific endotoxin sensing by TLR4/MD-22012
- Author(s)
  Umeharu Ohto
- Organizer
  Program for Young Researcher Symposium in Europe
- Place of Presentation
  Cambridge, UK
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] 自然免疫系RP105/MD-1複合体の構造解析2012
- Author(s)
  大戸梅治,三宅健介,清水敏之
- Organizer
  日本薬学会132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] 4本鎖lipid Aによる種特異的TLR4/MD-2活性化機構の構造基盤2012
- Author(s)
  大戸梅治, 深瀬浩一，三宅健介，清水敏之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] Structural analyses of mouse MD-1 protein complexed with endogenous phospholipid2011
- Author(s)
  Umeharu Ohto, Hitomi Harada, and Yoshinori Satow
- Organizer
  International Union of Crystallography 2011
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-23770106
[Presentation] Structural analyses of mouse MD-1 protein complexed with endogenous phospholipid2011
- Author(s)
  Umeharu Ohto, Hitomi Harada, Yoshinori Satow
- Organizer
  International Union of Crystallography 2011
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PUBLICLY-23121510
[Presentation] Human TLR4 polymorphisms influence cell surface expression and responses of TLR42011
- Author(s)
  Natsuko Yamakawa, Sachiko Akashi-Takamura, Umeharu Ohto, Natsuko Tanimura, Toshiyuki Shimizu, Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Crystal structures of human MD-2 recognizing bacterial endotoxin2007
- Author(s)
  Ohto, U. and Satow, Y
- Organizer
  Biochemistry and molecular Biology 2007
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19890048
[Presentation] Crystal twinning of human MD-2 protein recognizing endotoxin cores oflipopolysaccharide2007
- Author(s)
  Ohto, U. and Satow, Y
- Organizer
  International symposium on diffraction structural biology 2007
- Place of Presentation
  東京
- Year and Date
  2007-09-12
- Data Source
  KAKENHI-PROJECT-19890048
[Presentation] 自然免疫受容体NOD2の結晶構造解析
- Author(s)
  前川早貴子、大戸梅治、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] Toll様受容体8(TLR8)と一本鎖RNA複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邊俊明、三宅健介、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] Structural studies of nucleic acid sensing Toll-like receptor
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  23rd Congress and General Assembly of The International Union of Crystallography (IUCr 2014)
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-08-05 – 2014-08-12
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] 自然免疫系Toll様受容体の構造生物学研究
- Author(s)
  大戸梅治、清水敏之
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Structural study of Toll-like receptor 8 recognizing viral single stranded RNA
- Author(s)
  Umeharu Ohto
- Organizer
  The International Symposium ‘Molecular basis of host cell competency in virus infection’ 2014
- Place of Presentation
  Yokohama
- Year and Date
  2014-11-08 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] 自然免疫系Toll様受容体の構造生物学研究
- Author(s)
  大戸梅治、清水敏之
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] 自然免疫受容体NOD2の結晶構造解析
- Author(s)
  前川早貴子、大戸梅治、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] Toll様受容体8(TLR8)と一本鎖RNA複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邊俊明、三宅健介、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] Structural studies of nucleic acid sensing Toll-like receptor
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  23rd Congress and General Assembly of The International Union of Crystallography (IUCr 2014)
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-08-05 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] TLR8と一本鎖RNAとの複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、三宅健介、清水敏之
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] Structural studies of nucleic acid sensing Toll-like receptor
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  23rd Congress and General Assembly of The International Union of Crystallography (IUCr 2014)
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-08-05 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] 自然免疫系Toll様受容体の構造生物学研究
- Author(s)
  大戸梅治、清水敏之
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] Toll様受容体8(TLR8)と一本鎖RNA複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邊俊明、三宅健介、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] 自然免疫系Toll様受容体の構造生物学研究
- Author(s)
  大戸梅治、清水敏之
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] 自然免疫受容体NOD2の結晶構造解析
- Author(s)
  前川早貴子、大戸梅治、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] Toll様受容体8(TLR8)と一本鎖RNA複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邊俊明、三宅健介、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] Structural study of Toll-like receptor 8 recognizing viral single stranded RNA
- Author(s)
  Umeharu Ohto
- Organizer
  The International Symposium ‘Molecular basis of host cell competency in virus infection’ 2014
- Place of Presentation
  Yokohama
- Year and Date
  2014-11-08 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] Structural studies of nucleic acid sensing Toll-like receptor
- Author(s)
  U. Ohto, H. Tanji, T. Shibata, K. Miyake, and T.　Shimizu
- Organizer
  23rd Congress and General Assembly of The International Union of Crystallography (IUCr 2014)
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-08-05 – 2014-08-12
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] Structural study of Toll-like receptor 8 recognizing viral single stranded RNA
- Author(s)
  Umeharu Ohto
- Organizer
  The International Symposium ‘Molecular basis of host cell competency in virus infection’ 2014
- Place of Presentation
  Yokohama
- Year and Date
  2014-11-08 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PUBLICLY-25115504
[Presentation] TLR8と一本鎖RNAとの複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、三宅健介、清水敏之
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PUBLICLY-25121709
[Presentation] TLR8と一本鎖RNAとの複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、三宅健介、清水敏之
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] Structural study of Toll-like receptor 8 recognizing viral single stranded RNA
- Author(s)
  Umeharu Ohto
- Organizer
  The International Symposium ‘Molecular basis of host cell competency in virus infection’ 2014
- Place of Presentation
  Yokohama
- Year and Date
  2014-11-08 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-25650029
[Presentation] 自然免疫受容体NOD2の結晶構造解析
- Author(s)
  前川早貴子、大戸梅治、清水敏之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26711002
[Presentation] TLR8と一本鎖RNAとの複合体の結晶構造
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、三宅健介、清水敏之
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PUBLICLY-25115504

1. MIYAKE Kensuke (60229812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
2. NAKANISHI Hiroki (10466740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKAMURA Sachiko (00325599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SITOH Shin-ichiroh (90361625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. Uchiyama Susumu (90335381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. OKAMOTO Naoki (80727488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TAKI Hirofumi (10240780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ITO Tomoki (70434826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 保仙直毅 (10456923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGAI Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. DEGUCHI Atsuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 富田泰輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 古川鋼一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 下山敦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 村松正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 張志寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
17. 渡邉康春

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 中村英光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 清水敏之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 赤司祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
21. 門脇孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 富田毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 丸義朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 小川佳宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 井上直和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oto Umeharu 大戸 梅治

OHTO Umeharu 大戸 梅治

Research Projects

Research Products

Co-Researchers

ウイルス感染機構解明および感染制御法開発を目指した構造生物学研究Principal Investigator

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非典型的細胞内核酸センサ―を介した自然免疫応答の構造科学的解明Principal Investigator

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バイオロジカルクラスターを介した免疫機構およびその制御法の解明Principal Investigator

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Elucidation of regulation mechanism of the NLR inflammasome by the thioredoxin systemPrincipal Investigator

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Structural biology aiming regulation of viral infectionPrincipal Investigator

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Improving particle behaviors for cryo-EM analysis by PEGylationPrincipal Investigator

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一回膜貫通型受容体のシグナル伝達の構造基盤Principal Investigator

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Elucidation of a complete picture of the activation mechanism of Toll-like receptors in lipid bilayers by multilevel analysisPrincipal Investigator

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リポクオリティとTLR活性化機構の解析Principal Investigator

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一回膜貫通型受容体のシグナル伝達の構造基盤Principal Investigator

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Physico-chemical and mathematical analyses of immune related signal induced by antibody aggregates

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The development of therapeutic agents for SLE based on inhibition of innate immune receptor TLR7

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Structural elucidation of dioxin recognition by aryl hydrocarbon receptorPrincipal Investigator

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Oto Umeharu 大戸梅治

OHTO Umeharu 大戸梅治