NEGISHI TAKAKO 根岸貴子 (古賀貴子)

… Alternative Names

古賀貴子

KOGA Takako 古賀貴子

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Researcher Number	90451905
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 順天堂大学, 大学院医学研究科, 特任准教授 2020: 順天堂大学, 医学(系)研究科, 非常勤講師 2019 – 2020: 東京大学, 医科学研究所, 特任准教授 2015 – 2018: 昭和大学, 歯学部, 講師 2014: 東京大学, 大学院医学系研究科(医学部), 特任助教 … More 2013 – 2014: 東京大学, 医学(系)研究科(研究院), 助教 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, その他 2010: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 客員助教 2009: Tokyo Medical and Dental University, 医歯学総合研究科, 客員助教 2007 – 2009: 東京医科歯科大学, 大学院・医歯学総合研究科, 特任助教 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / Basic Section 49010:Pathological biochemistry-related / Studies on the Super-Aging Society / Orthopaedic surgery / Functional basic dentistry Except Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 49030:Experimental pathology-related / Basic Section 57030:Conservative dentistry-related / Periodontology
Keywords	Principal Investigator 破骨細胞 / 骨代謝 / 骨芽細胞 / 骨代謝学 / 骨粗鬆症 / 老化 / 免疫 / シグナル伝達 / 翻訳語修飾 / タンパク質メチル化酵素 … More / 転写因子 / 生体分子医学 / 認知疾患 / 加齢 / 加齢性疾患 / 高次生体相互連関 / 骨免疫学 / 中枢神経 / 神経変性疾患 / 認知症 / 自己免疫疾患 / 骨粗しょう症 / 免疫複合体 / RANKL / 細胞間制御 / 神経突起伸長 / 突起伸長 / 神経細胞 / 生理活性 / 発生 / 生体分子 / メチル化 / 生体制御 / 細胞分化 / タンパク質修飾 / アルギニンメチル化 / 生体恒常性 / タンパク質翻訳後修飾 / 免疫系細胞 / 細胞間相互作用 / 翻訳後修飾 / 骨代謝疾患 … More Except Principal Investigator 破骨細胞 / 骨代謝 / 象牙質 / 脂質代謝 / 骨芽細胞 / 軟骨摩耗 / 半月板逸脱 / 骨棘 / 軟骨下骨病変 / 変形性膝関節症 / 組織破壊・修復 / CEMIP / ヒアルロン酸 / IL-6 / 癌細胞浸潤 / TMEM2 / HYBID / ヒアルロン酸分解 / 変形性関節症 / 歯質形成 / 歯 / 骨恒常性 / 骨 / 薬理学 / 再生医学 / 歯学 / 骨密度 / 細胞・組織 / 免疫学 / 生理学 / シグナル伝達 / 整形外科学 / 骨代謝学 / プロテオーム / トランスクリプトーム / ノックアウトマウス / Th17細胞 / 骨細胞 / リンパ球 / 疾患モデル / 自己免疫 / 骨疾患 / 骨免疫学 Less

ヒアルロン酸分解が誘導する異所性骨化・石灰化制御機構Principal Investigator
- Principal Investigator
  
  根岸貴子 (古賀貴子)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Pathophysiology and mechanism of the progression of subchondral bone lesions in knee osteoarthritis
- Principal Investigator
  
  石島旨章
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Juntendo University
Expression and functional analysis of hyaluronan-degrading molecule HYBID and its role in tissue destruction and repair
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Lipid metabolic functions in tooth and bone homeostasis
- Principal Investigator
  
  Sakai Nobuhiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Showa University
Research for the development of methods to control age-related diseases and bone diseasesPrincipal Investigator
- Principal Investigator
  
  Negishi Takako
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Juntendo University
  The University of Tokyo
Network between bone and CNSPrincipal Investigator
- Principal Investigator
  
  NEGISHI TAKAKO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
  Showa University
Development of a method for suppressing bone destruction targeting cholesterol acyltransferase.
- Principal Investigator
  
  Sakai Nobuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Showa University
Bone metabolism by immune complexesPrincipal Investigator
- Principal Investigator
  
  Koga Takako
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Showa University
Post-translational modification by symmetric ariginine dimetylation in immune regulation and diseasesPrincipal Investigator
- Principal Investigator
  
  Koga Takako
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Showa University
  The University of Tokyo
  Tokyo Medical and Dental University
The investigation of the role of bone in the regulation of neuron.Principal Investigator
- Principal Investigator
  
  KOGA Takako
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
軸策ガイダンス、セマフォリン分子による硬組織代謝細胞間制御機構の解明Principal Investigator
- Principal Investigator
  
  古賀貴子
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
The methylation of non-histone proteins in bone diseasesPrincipal Investigator
- Principal Investigator
  
  KOGA Takako
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Osteoimmunology
- Principal Investigator
  
  TAKAYANAGI Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Tokyo Medical and Dental University

[Book] リウマチ科(「骨免疫学研究の歴史とup to date」)第40巻第2号2008
- Author(s)
  古賀貴子, 高柳広
- Publisher
  科学評論社出版
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] IL-6 Reduces Spheroid Sizes of Osteophytic Cells Derived from Osteoarthritis Knee Joint via Induction of Apoptosis2024
- Author(s)
  Negishi Yoshifumi、Adili Arepati、de Vega Susana、Momoeda Masahiro、Kaneko Haruka、Cilek Mehmet Z.、Yoshinaga Chiho、Takafuji Kazuaki、Otsuka Yuta、Shimoda Masayuki、Negishi-Koga Takako、Ishijima Muneaki、Okada Yasunori
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 194 Issue: 1 Pages: 135-149
- DOI
  10.1016/j.ajpath.2023.10.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09259, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-18K09082
[Journal Article] Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study2023
- Author(s)
  Negishi Y、Kaneko H、Aoki T、Liu L、Adili A、Arita H、Hada S、Momoeda M、Huang H、Tomura J、Wakana S、Shiozawa J、Kubota M、Someya Y、Tamura Y、Aoki S、Watada H、Kawamori R、Negishi-Koga T、Okada Y、Ishijima M
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 22805-22805
- DOI
  10.1038/s41598-023-49868-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15750, KAKENHI-PROJECT-21K09259, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-18K09082
[Journal Article] Anterior meniscus extrusion is associated with anterior tibial osteophyte width in knee osteoarthritis-The Bunkyo Health Study2023
- Author(s)
  Adili A, Kaneko H, Aoki T, Liu L, Negishi Y, Tomura J, Wakana S, Momoeda M, Arita H, Hada S, Shiozawa J, Kubota M, Someya Y, Tamura Y, Aoki S, Watada H, Kawamori R, Negishi-Koga T, Okada Y, Ishijima M
- Journal Title
  
  Osteoarthritis and Cartilage Open
  
  Volume: 5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20496
[Journal Article] Anterior meniscus extrusion is associated with anterior tibial osteophyte width in knee osteoarthritis ? The Bunkyo Health Study2023
- Author(s)
  Adili Arepati、Kaneko Haruka、Aoki Takako、Liu Lizu、Negishi Yoshifumi、Tomura Jun、Wakana Suguru、Momoeda Masahiro、Arita Hitoshi、Hada Shinnosuke、Shiozawa Jun、Kubota Mitsuaki、Someya Yuki、Tamura Yoshifumi、Aoki Shigeki、Watada Hirotaka、Kawamori Ryuzo、Negishi-Koga Takako、Okada Yasunori、Ishijima Muneaki
- Journal Title
  
  Osteoarthritis and Cartilage Open
  
  Volume: 5 Issue: 3 Pages: 100364-100364
- DOI
  10.1016/j.ocarto.2023.100364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15750, KAKENHI-PROJECT-21K09259, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-18K09082
[Journal Article] Periosteal stem cells control growth plate stem cells during postnatal skeletal growth2022
- Author(s)
  Tsukasaki M, Komatsu N, Negishi-Koga T, Huynh NC, Muro R, Ando Y, Seki Y, Terashima A, Pluemsakunthai W, Nitta T, Nakamura T, Nakashima T, Ohba S, Akiyama H, Okamoto K, Baron R, Takayanagi H
- Journal Title
  
  Nat Commun
  
  Volume: 13 Issue: 1 Pages: 4166-4166
- DOI
  10.1038/s41467-022-31592-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07114, KAKENHI-PROJECT-21K18254, KAKENHI-PROJECT-21H05046, KAKENHI-PROJECT-20H00551, KAKENHI-PROJECT-21H03104, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-21K19371, KAKENHI-PROJECT-21K19554, KAKENHI-PROJECT-23K24106, KAKENHI-PROJECT-23K24148, KAKENHI-PROJECT-23K24454
[Journal Article] Medial meniscus extrusion is directly correlated with medial tibial osteophyte in patients received reconstruction surgery for anterior cruciate ligament injury: A longitudinal study.2022
- Author(s)
  Hada S., Kaneko H., Liu L., Aoki T., Takamura T., Kinoshita M., Arita H., Shiozawa J., Negishi Y., Momoeda M., Kubota M., Aoki S., Okada Y. and Ishijima M.
- Journal Title
  
  Osteoarthr Cartil Open
  
  Volume: 4 Pages: 100320-100320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07029
[Journal Article] Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage2022
- Author(s)
  Shiozawa Jun、de Vega Susana、Yoshinaga Chiho、Ji Xang、Negishi Yoshifumi、Momoeda Masahiro、Nakamura Tomomi、Yoshida Hiroyuki、Kaneko Haruka、Ishijima Muneaki、Okada Yasunori
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 17242-17242
- DOI
  10.1038/s41598-022-22230-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-22K07029, KAKENHI-PROJECT-20K18075
[Journal Article] Inhibition of hepatocyte growth factor/c-Met signalling abrogates joint destruction by suppressing monocyte migration in rheumatoid arthritis.2021
- Author(s)
  Hosonuma M, Sakai N, Furuya H, Kurotaki Y, Sato Y, Handa K, Dodo Y, Ishikawa K, Tsubokura Y, Negishi-Koga T, Tsuji M, Kasama T, Kiuchi Y, Takami M, Isozaki T.
- Journal Title
  
  Rheumatology
  
  Volume: 60 Pages: 408-419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20496
[Journal Article] 抗RANKLモノクローナル抗体がマウス脊椎固定術モデルの骨癒合に及ぼす影響2021
- Author(s)
  谷聡二, 石川紘司, 古賀貴子, 工藤理史, 松岡彰, 丸山博史, 山村亮, 早川周良, 関水壮哉, 土谷弘樹, 辻まゆみ, 木内祐二, 永井隆士, 豊根知明, 稲垣克記
- Journal Title
  
  Journal of Spine Research
  
  Volume: 12 Pages: 538-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20496
[Journal Article] Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice2020
- Author(s)
  Kiyohara S, Sakai N, Handa K, Yamakawa T, Ishikawa K, Chatani M, Karakawa A, Azetsu Y, Munakata M, Ozeki M, Negishi-Koga T, Takami M
- Journal Title
  
  J Oral Biosci
  
  Volume: - Issue: 2 Pages: 131-138
- DOI
  10.1016/j.job.2020.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17J11294, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-19K18544, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Effects of N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice2020
- Author(s)
  Kiyohara S, Sakai N, Handa K, Yamakawa T, Chatani M, Karakawa A, Azetsua Y, Munakata M, Ozeki M, Negishi-Koga T, Takami M
- Journal Title
  
  J. Oral Biosciences
  
  Volume: S1349-0079(20) Pages: 30046-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11993
[Journal Article] Inhibition of hepatocyte growth factor/c-Met signalling abrogates joint destruction by suppressing monocyte migration in rheumatoid arthritis2020
- Author(s)
  Hosonuma Masahiro、Sakai Nobuhiro、Furuya Hidekazu、Kurotaki Yutaro、Sato Yurie、Handa Kazuaki、Dodo Yusuke、Ishikawa Koji、Tsubokura Yumi、Negishi-Koga Takako、Tsuji Mayumi、Kasama Tsuyoshi、Kiuchi Yuji、Takami Masamichi、Isozaki Takeo
- Journal Title
  
  Rheumatology
  
  Volume: 60 Issue: 1 Pages: 408-419
- DOI
  10.1093/rheumatology/keaa310
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-19K18544, KAKENHI-PROJECT-20K17431
[Journal Article] Myelination during fracture healing in vivo in myelin protein zero (p0) transgenic medaka line2020
- Author(s)
  Dodo Y, Chatani M, Azetsu Y, Hosonuma M, Karakawa A, Sakai N, Negishi-Koga T, Tsuji M, Inagaki K, Kiuchi Y, Takami M
- Journal Title
  
  Bone
  
  Volume: 133 Pages: 115225-115225
- DOI
  10.1016/j.bone.2020.115225
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17J11294, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-20K17431, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-19KK0233, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts2020
- Author(s)
  Yamakawa Tomoyuki、Okamatsu Nobuaki、Ishikawa Koji、Kiyohara Shuichi、Handa Kazuaki、Hayashi Erika、Sakai Nobuhiro、Karakawa Akiko、Chatani Masahiro、Tsuji Mayumi、Inagaki Katsunori、Kiuchi Yuji、Negishi-Koga Takako、Takami Masamichi
- Journal Title
  
  Bone
  
  Volume: 138 Pages: 115494-115494
- DOI
  10.1016/j.bone.2020.115494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-19K18544, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-18K09866
[Journal Article] Effects of lipid metabolism on mouse incisor dentinogenesis.2020
- Author(s)
  Kurotaki, Y., Sakai, N., Miyazaki, T., Hosonuma, M., Sato, Y., Karakawa, A., Chatani, M., Myers, M., Suzawa, T., Negishi-Koga, T., Kamijo, R., Miyazaki, A., Maruoka, Y., Takami, M.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5102-5102
- DOI
  10.1038/s41598-020-61978-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09511, KAKENHI-PROJECT-18K09866, KAKENHI-PROJECT-19K08590, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-17H04050
[Journal Article] A Delphinidin-Enriched Maqui Berry Extract Improves Bone Metabolism and Protects against Bone Loss in Osteopenic Mouse Models2019
- Author(s)
  Nagaoka Masahiro、Maeda Toyonobu、Chatani Masahiro、Handa Kazuaki、Yamakawa Tomoyuki、Kiyohara Shuichi、Negishi-Koga Takako、Kato Yasumasa、Takami Masamichi、Niida Shumpei、Lang Stefanie、Kruger Marlena、Suzuki Keiko
- Journal Title
  
  Antioxidants
  
  Volume: 8 Issue: 9 Pages: 386-386
- DOI
  10.3390/antiox8090386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09642, KAKENHI-PROJECT-19K10074, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17H04050
[Journal Article] Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice2019
- Author(s)
  Isawa M, Karakawa, Sakai N, Nishina S, Kuritani M, Chatani M, Negishi-Koga T, Sato M, Inoue M, Shimada Y, Takami M
- Journal Title
  
  Sci Rep
  
  Volume: 9(1) Issue: 1 Pages: 19895-19895
- DOI
  10.1038/s41598-019-56151-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PROJECT-19K19035, KAKENHI-PROJECT-19K21416, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935
[Journal Article] Treatment with synthetic glucocorticoid impairs bone metabolism, as revealed by in vivo imaging of osteoblasts and osteoclasts in medaka fish2019
- Author(s)
  Azetsu, Y., Chatani M, Dodo Y, Karakawa A, Sakai N, Negishi-Koga T, Takami M
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 118 Pages: 109101-109101
- DOI
  10.1016/j.biopha.2019.109101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17J11294, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935
[Journal Article] Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson’s disease model mice2019
- Author(s)
  Handa Kazuaki、Kiyohara Shuichi、Yamakawa Tomoyuki、Ishikawa Koji、Hosonuma Masahiro、Sakai Nobuhiro、Karakawa Akiko、Chatani Masahiro、Tsuji Mayumi、Inagaki Katsunori、Kiuchi Yuji、Takami Masamichi、Negishi-Koga Takako
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 13768-13768
- DOI
  10.1038/s41598-019-50336-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18544, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-17K18114, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935
[Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019
- Author(s)
  Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Issue: 47 Pages: 23653-23661
- DOI
  10.1073/pnas.1915326116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07166, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-17H04050
[Journal Article] Anti-mouse RANKL Antibodies Inhibit Alveolar Bone Destruction in Periodontitis Model Mice2018
- Author(s)
  Kuritani M, Sakai N, Karakawa A, Isawa M, Chatani M, Negishi-Koga T, Funatsu T, Takami M.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 4 Pages: 637-643
- DOI
  10.1248/bpb.b18-00026
- NAID
  130006602562
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293398, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-16K20655, KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-16K15778, KAKENHI-PUBLICLY-16H01635, KAKENHI-PROJECT-17K11993, KAKENHI-ORGANIZER-15H05935
[Journal Article] Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance2018
- Author(s)
  Inoue Maia、Okamoto Kazuo、Terashima Asuka、Nitta Takeshi、Muro Ryunosuke、Negishi-Koga Takako、Kitamura Toshio、Nakashima Tomoki、Takayanagi Hiroshi
- Journal Title
  
  Nature Immunology
  
  Volume: 19 Issue: 11 Pages: 1265-1276
- DOI
  10.1038/s41590-018-0222-z
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05788, KAKENHI-PROJECT-16H05202, KAKENHI-PROJECT-16H05506, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-18H02919, KAKENHI-PROJECT-17K19582, KAKENHI-PROJECT-16K19102, KAKENHI-PROJECT-15H05703
[Journal Article] 免疫系分子による骨代謝調節2017
- Author(s)
  古賀貴子
- Journal Title
  
  骨粗鬆症治療
  
  Volume: １ Pages: 39-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293066
[Journal Article] イムノグロブリンによる骨粗鬆症―新たな骨粗鬆症バイオマーカーの可能性2017
- Author(s)
  古賀貴子
- Journal Title
  
  整形外科学
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293066
[Journal Article] 免疫系分子による骨代謝調節2017
- Author(s)
  古賀貴子
- Journal Title
  
  骨粗鬆症治療
  
  Volume: １ Pages: 39-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15538
[Journal Article] Biological effects of anti-RANKL antibody administration in pregnant mice and their newborns.2017
- Author(s)
  Okamatsu N, Sakai N, Karakawa A, Kouyama N, Sato Y, Inagaki K, Kiuchi Y, Oguchi K, Negishi-Koga T, Takami M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 491 Issue: 3 Pages: 614-621
- DOI
  10.1016/j.bbrc.2017.07.154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293398, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-16K20655, KAKENHI-PROJECT-17K11993
[Journal Article] イムノグロブリンによる骨粗鬆症―新たな骨粗鬆症バイオマーカーの可能性2017
- Author(s)
  古賀貴子
- Journal Title
  
  整形外科学
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15538
[Journal Article] Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems2017
- Author(s)
  Okamoto Kazuo、Nakashima Tomoki、Shinohara Masahiro、Negishi-Koga Takako、Komatsu Noriko、Terashima Asuka、Sawa Shinichiro、Nitta Takeshi、Takayanagi Hiroshi
- Journal Title
  
  Physiological Reviews
  
  Volume: 97 Issue: 4 Pages: 1295-1349
- DOI
  10.1152/physrev.00036.2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19582, KAKENHI-PUBLICLY-16H01634, KAKENHI-PROJECT-16H05202, KAKENHI-PROJECT-16H05506, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-15H05653, KAKENHI-PROJECT-15F15414, KAKENHI-PROJECT-16K14648, KAKENHI-PROJECT-15H05703, KAKENHI-PROJECT-16K15252, KAKENHI-PROJECT-26713015, KAKENHI-PROJECT-15K15149
[Journal Article] Immune complexes regulate bone metabolism through FcRγ signalling2015
- Author(s)
  Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 6637-6637
- DOI
  10.1038/ncomms7637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25111503, KAKENHI-PROJECT-25670188, KAKENHI-PROJECT-25670228, KAKENHI-PROJECT-15K10488, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-15K15538, KAKENHI-PROJECT-15H05653, KAKENHI-PROJECT-15F15414, KAKENHI-PROJECT-13J40074, KAKENHI-PROJECT-15H05703
[Journal Article] Role of septins in the orientation of forespore-membrane extension during sporulation in fission yeast.2010
- Author(s)
  Masayuki Onishi, Takako Koga, Aiko Hirata, Taro Nakamura, Haruhiko Asakawa, Chikashi Shimoda, Jurg Bahler, Jian-Qiu Wu, Kaoru Takegawa, Hiroyuki Tachikawa, John R.Pringle, Yasuhisa Fukui.
- Journal Title
  
  Mol.Cell.Biol. 30(8)
  
  Pages: 2059-2074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Ca^<2+>-NFATc1 signaling is an essential axix of osteoclast differentiation.2009
- Author(s)
  Takako Negishi-Koga, Hiroshi Takayanagi.
- Journal Title
  
  Immunological Reviews 231(1)
  
  Pages: 241-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis.2009
- Author(s)
  Baohong Zhao, Masamichi Takami, Atsushi Yamada, Xiaogu Wang, Takako Koga, Xiaoyu Hu, Tomohiko Tamura, Keiko Ozato, Yongwon Choi, Lionel B Ivashkiv, Hiroshi Takayanagi, Ryutaro Kamijo.
- Journal Title
  
  Nature Medicine. 15(9)
  
  Pages: 1066-1071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] A unique domain in RANK is required for Gab2 and PLCγ2 binding to establish osteoclastogenic signals.2009
- Author(s)
  Yuu Taguchi, Jin Gohda, Takako Koga, Hiroshi Takayanagi, Jun-ichiro Inoue.
- Journal Title
  
  Genes Cells. 14(11)
  
  Pages: 1331-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Mysteries in Ca^<2+> Signaling During Osteoclast Differentiation2009
- Author(s)
  古賀貴子
- Journal Title
  
  IBMS BoneKEy
  
  Pages: 301-306
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation2009
- Author(s)
  古賀貴子
- Journal Title
  
  Immunological Reviews 231
  
  Pages: 241-256
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Mysteries in Ca^<2+> Signaling During Osteoclast Differentiation2009
- Author(s)
  古賀貴子
- Journal Title
  
  IBMS BoneKEy
  
  Pages: 301-306
- Data Source
  KAKENHI-PROJECT-21659428
[Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation2009
- Author(s)
  古賀貴子
- Journal Title
  
  Immunological Reviews 231
  
  Pages: 241-256
- Data Source
  KAKENHI-PROJECT-21659428
[Journal Article] Mysteries in Ca^<2+> signaling during osteoclast differentiation.(Articles)2009
- Author(s)
  Takako Negishi-Koga, Hiroshi Takayanagi.
- Journal Title
  
  IBMS BoneKEy 6(8)
  
  Pages: 301-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Mysteries in Ca^<2+> Signaling During Osteoclast Differentiation2009
- Author(s)
  古賀貴子
- Journal Title
  
  IBMS BoneKEy
  
  Pages: 301-306
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation2009
- Author(s)
  古賀貴子
- Journal Title
  
  Immunological Reviews(Review) 231
  
  Pages: 241-256
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation2009
- Author(s)
  Negishi-Koga, T., Takayanagi, H.
- Journal Title
  
  Immunological Reviews 231
  
  Pages: 241-256
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.2008
- Author(s)
  Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T
- Journal Title
  
  J Immunol 181
  
  Pages: 4742-4751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] 骨免疫学研究の歴史とup to date2008
- Author(s)
  古賀貴子
- Journal Title
  
  リウマチ科 40
  
  Pages: 105-111
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008
- Author(s)
  Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S.Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier, Hiroshi Takayanagi.
- Journal Title
  
  Cell. 132(5)
  
  Pages: 794-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.2008
- Author(s)
  Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T.
- Journal Title
  
  J Immunol. 181(7)
  
  Pages: 4742-4751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008
- Author(s)
  Shiohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
- Journal Title
  
  Cell 132
  
  Pages: 794-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] 骨免疫学研究の歴史とup to date2008
- Author(s)
  古賀貴子, 高柳広
- Journal Title
  
  リウマチ科(科学評論社) 40
  
  Pages: 105-111
- Data Source
  KAKENHI-PROJECT-20689007
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008
- Author(s)
  Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T., Kodama, T., Morio, T., Geha, R. S., Kitamura, D., Kurosaki, T., Ellmeier, W., Takayanagi, H.
- Journal Title
  
  Cell 132
  
  Pages: 794-806
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss2007
- Author(s)
  Ochi, S., Shinohara, M., Sato, K., Gober H. J., Koga, T., Kodama, T., Takai T., Miyasaka N., Takayanagi H.
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 11394-11399
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.2006
- Author(s)
  Negishi, H, Fujita, Y, Yanai, H, Sakaguchi, S, Ouyang, X, Shinohara, M, Takayanagi, H, Ohba, Y, Taniguchi, T, Honda, K.
- Journal Title
  
  Proc Natl Acad Sci 103・41
  
  Pages: 15136-41
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Statl-mediated cytoplasmic attenuation in osteoimmunology.2005
- Author(s)
  Takayanagi, H., Kim, S., Koga, T., Taniguchi, T.
- Journal Title
  
  J Cell Biochem 94・2
  
  Pages: 232-240
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] NFAT and Osterix cooperatively regulate bone formation2005
- Author(s)
  Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima K., Takayanagi, H.
- Journal Title
  
  Nat Med 11
  
  Pages: 880-885
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] RANK-mediated amplification of TRAF6 signaling leads to NFATcl induction during osteoclastogenesis.2005
- Author(s)
  Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., Inoue, J.
- Journal Title
  
  EMBO 24・4
  
  Pages: 790-799
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] NFAT and Osterix cooperatively regulate bone formation.2005
- Author(s)
  Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B., Nakashima K., Takayanagi, H.
- Journal Title
  
  Nat Med 11・8
  
  Pages: 880-885
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] インターロイキン-6による変形性膝関節症由来骨棘細胞のスフェロイド形成抑制作用2023
- Author(s)
  根岸義文, Adili Arepati, Susana de Vega, 百枝雅裕, 金子晴香, Mehmet Zeynel Cilek, 良永知穂, 高藤和輝, 大塚祐多,下田将之, 根岸貴子, 石島旨章, 岡田保典
- Organizer
  第55回日本結合組織学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] Mouse model of uncoupled bone remodeling upon discontinuation of anti-RANKL antibody therapy2023
- Author(s)
  Koji Ishikawa, Soji Tani, Nobuhiro Sakai, Yoshifumi Kudo, Hideyo Horiuchi, Hiromi Kimura-Suda, Masamichi Takami, Mayumi Tsuji, Katsunori Inagaki, Yuji Kiuchi, Takako Negishi-Koga
- Organizer
  The American Society for Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20496
[Presentation] インターロイキン-6による変形性膝関節症由来骨棘細胞のスフェロイド形成抑制作用2023
- Author(s)
  根岸義文、 Adili Arepati、 Susana de Vega、百枝雅裕、金子晴香、Mehmet Zeynel Cilek、良永知穂、高藤和輝、大塚祐多、下田将之、根岸貴子、石島旨章、岡田保典
- Organizer
  第55回日本結合組織学会学術集会
- Data Source
  KAKENHI-PROJECT-20K20496
[Presentation] 変形性膝関節症（膝変形性関節症）関節軟骨細胞でのヒアルロン酸分解酵素（HYBIDとTMEM2）の発現調節機構2023
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、根岸義文、百枝雅裕、中村智美、吉田浩之、金子晴香、石島旨章、岡田保典
- Organizer
  第112回日本病理学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] EXPRESSION AND REGULATION OF RECENTLY DISCOVERED HYALURONIDASES (HYBID AND TMEM2) IN CONDROCYTES FROM KNEE OA CARTILAGE2023
- Author(s)
  Jun Shiozawa, Susana de Vega, Chiho Yoshinaga, Xang Ji, Yoshifumi Negishi, Masahiro Momoeda, Tomomi Nakamura, Hiroyuki Yoshida, Haruka Kaneko, Muneaki Ishijima, and Yasunori Okada
- Organizer
  2023 OARSI World Congress on Osteoarthritis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] ヒアルロン酸分解酵素（HYBIDとTMEM2）の変形性関節症（変形性関節症）関節軟骨細胞での発現、ヒアルロン酸分解活性、発現調節機構2023
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、Xang Ji、根岸義文、百枝雅裕、中村智美、吉田浩之、金子晴香、石島旨章、岡田保典
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] 関節軟骨破壊に関わる新規ヒアルロン酸分解酵素（HYBIDとTMEM2）の変形性関節症（OA）関節軟骨での発現調節機構2022
- Author(s)
  塩澤淳、Susana de Vega、良永知穂、根岸義文、百枝雅裕、中村智美、吉田浩之、金子晴香、石島旨章、岡田保典
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K07029
[Presentation] 新規遺伝子Merlot は破骨細胞分化を阻害しアポトーシスを促進させる2021
- Author(s)
  山川智之，岡松伸明，石川紘司，清原秀一，飯田和章，坂井信裕，唐川亜希子，茶谷昌宏，辻まゆみ，稲垣克記，木内祐二，根岸貴子，髙見正道
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 抗RANKL抗体治療の中断による骨代謝破綻の機序2021
- Author(s)
  石川紘司, 谷聡二, 坂井信裕, 高見正道, 堀内秀与, 木村廣美[須田], 辻まゆみ, 木内祐二, 稲垣克記, 根岸貴子[古賀]
- Organizer
  日本骨形態計測学会
- Data Source
  KAKENHI-PROJECT-20K20496
[Presentation] Hepatocyte growth factor(HGF)/ c-MET シグナル阻害は単球遊走を介した関節リウマチの骨破壊を抑制する2020
- Author(s)
  細沼雅弘，坂井信裕，黒滝優太朗，佐藤ゆり絵，古屋秀和，磯崎健男，古賀貴子，辻まゆみ，木内祐二，笠間毅，髙見正道
- Organizer
  第5回日本骨免疫学会ウィンタースクール
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは切歯象牙質の肥厚と骨密度の減少を呈する2019
- Author(s)
  黒滝優太朗、坂井信裕、佐藤ゆり絵、唐川亜希子、茶谷昌弘、古賀貴子、丸岡靖史、高見正道
- Organizer
  第61回日本歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは切歯の象牙質肥厚を伴う歯髄狭窄を呈する2019
- Author(s)
  黒滝優太郎，坂井信裕，宮崎拓郎，細沼雅弘，佐藤ゆり絵，唐川亜希子，茶谷昌宏，マイヤース三恵，須澤徹夫，根岸（古賀）貴子，上條竜太郎，宮崎章，髙見正道，丸岡靖史
- Organizer
  第66回昭和大学学士会総会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質代謝は歯と骨の恒常性維持を制御する2019
- Author(s)
  黒滝優太朗、坂井信裕、細沼雅弘、古賀貴子、唐川亜希子、茶谷昌宏、マイヤース三恵、丸岡靖史，高見正道
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは切歯象牙質の肥厚と骨量減少を呈する2019
- Author(s)
  黒滝優太朗, 坂井信裕, 佐藤ゆり絵, 唐川亜希子, 茶谷昌弘, 古賀貴子, 高見正道
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 関節リウマチの滑膜におけるHepatocyte growth factor (HGF)の発現と病的意義2019
- Author(s)
  細沼雅弘，磯崎健男，古屋秀和，黒滝優太朗，佐藤ゆり絵，坂井信裕，茶谷昌宏，唐川亜希子，古賀貴子，高見正道，辻まゆみ，木内祐二
- Organizer
  第26回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] パーキンソン病モデルマウスの骨代謝の解析2018
- Author(s)
  5.飯田和章、山川智之、清原秀一、坂井信裕、唐川亜希子、木内祐二、稲垣克記、古賀貴子、高見正道
- Organizer
  第36回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 脂質異常症モデルマウスは骨量減少と歯髄狭窄を発症する2018
- Author(s)
  黒滝優太朗，坂井信裕，唐川亜希子，茶谷昌弘，根岸-古賀貴子，高見正道
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] パーキンソン病モデルマウスにおける骨代謝制御の解析2018
- Author(s)
  1.飯田和章、清原秀一、山川智之、坂井信裕、唐川亜希子、木内祐二、古賀貴子、高見正道、稲垣克記
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] ゾレドロネートは若齢マウスの成長と歯の発育を阻害する2018
- Author(s)
  9.唐川亜希子、井澤基樹、坂井信裕、古賀貴子、茶谷正宏、島田幸恵、高見正道
- Organizer
  文部科学省私立大学戦略的研究基盤形成支援事業平成29年度シンポジウム
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 歯周病モデルマウスに対する抗RANKL抗体の歯槽骨破壊抑制効果2018
- Author(s)
  4.栗谷未来、坂井信裕、唐川亜希子、井澤基樹、黒滝優太郎、茶谷正宏、根岸貴子、高見正道
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] Administration of anti-RANKL antibody to pregnant mice results in impaired development of mammary gland and death of newborns2018
- Author(s)
  N. Sakai, N. Okamatsu, T. Negishi-Koga, A. Karakawa, M. Chatani, Y. Kiuchi, M. Takami
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] NKT細胞の初期分化に必須な制御因子の同定2018
- Author(s)
  6.寺島明日香、井上真以亜、岡本一男、根岸（古賀）貴子、中島友紀
- Organizer
  第4回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] Effect of anti-RANKL antibody and zoledoronate on development of young mice.2018
- Author(s)
  1.Akiko Karakawa, Motoki Isawa, Nobhiro Sakai, Takako Negishi-Koga, Masahiro Chatani, Masamichi Takami,
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 歯周病モデルマウスに対する抗RANKL抗体の歯槽骨破壊抑制効果2018
- Author(s)
  栗谷未来，坂井信裕，唐川亜希子，井澤基樹，黒滝優太朗，茶谷昌弘，根岸-古賀貴子，高見正道
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] パーキンソン病モデルマウスの骨代謝の解析2018
- Author(s)
  7.飯田和章、山川智之、清原秀一、坂井信裕、唐川亜希子、木内祐二、稲垣克記、古賀貴子、高見正道
- Organizer
  第4回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] パーキンソン病治療薬による骨代謝制御2018
- Author(s)
  2.清原秀一、飯田和章、山川智之、坂井信裕、唐川亜希子、尾関雅彦、古賀貴子、高見正道
- Organizer
  第60回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 破骨細胞に高発現する未同定遺伝子の解析2018
- Author(s)
  10.山川智之、清原秀一、飯田和章、岡松伸明、坂井信裕、稲垣克記、木内祐二、古賀貴子、高見正道
- Organizer
  第4回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 骨損傷修復モデル動物に対するパーキンソン病治療薬の作用2018
- Author(s)
  8.清原秀一、飯田和章、山川智之、坂井信裕、尾関雅彦、古賀貴子、高見正道
- Organizer
  第4回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 骨吸収抑制作用を有する抗RANKL抗体を投与した妊娠マウスおよびその新生仔の解析2017
- Author(s)
  坂井信裕、岡松伸明、古賀貴子、唐川亜希子、稲垣克記、高見正道
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 抗RANKL抗体が妊娠マウスに与える影響2017
- Author(s)
  岡松伸明、坂井信裕、古賀貴子、木内祐二、小口勝司、高見正道
- Organizer
  第90回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 骨吸収抑制薬が若齢マウスの成長と歯の発育に及ぼす影響2017
- Author(s)
  井澤基樹, 唐川亜希子, 坂井信裕, 根岸貴子, 茶谷昌宏, 高見正道, 島田幸惠
- Organizer
  第338回昭和大学学士会例会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] Effects of Anti-RANKL Antibody and Zoledronate on Growth and Tooth Development in Young Mice2017
- Author(s)
  Motoki ISAWA, Akiko KARAKAWA, Nobuhiro SAKAI, Takako NEGISHI, Masahiro CHATANI, Miku KURITANI, Yukie SHIMADA, Masamichi TAKAMI
- Organizer
  第65回国際歯科研究学会日本部会学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] Anti-RANKL Antibody Administration Suppresses Bone Destruction Induced by LPS in Mice2017
- Author(s)
  Miku Kuritani，Nobuhiro Sakai，Akiko Karakawa，Masahiro Chatani，Motoki Isawa, Takako Koga，TakahiroFunatsu，Masamichi Takami
- Organizer
  第65回国際歯科研究学会日本部会総会学術大会(JADR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 抗RANKL抗体とゾレドロネートがマウスのLPS誘導性炎症性骨破壊に及ぼす影響2017
- Author(s)
  栗谷未来、坂井信裕、唐川亜希子、茶谷昌宏、古賀貴子、高見正道
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] 抗RANKL抗体とゾレドロネートがマウスのLPS誘導性炎症性骨破壊に及ぼす影響2017
- Author(s)
  栗谷未来、坂井信裕、唐川亜希子、茶谷昌宏、古賀貴子、高見正道
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 抗RANKL抗体が妊娠マウスと胎児に与える影響2017
- Author(s)
  岡松伸明，坂井信裕，根岸貴子，木内裕二，小口勝司，高見正道
- Organizer
  第90回日本薬理学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 骨吸収抑制薬が若齢マウスの成長と歯の発育に及ぼす影響2017
- Author(s)
  井澤基樹, 唐川亜希子, 坂井信裕, 根岸貴子,　茶谷昌宏, 栗谷未来, 高見正道
- Organizer
  第59回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] ビスホスホネートは若齢マウスの成長と歯の生育を阻害する2017
- Author(s)
  唐川亜希子，井澤基樹，坂井信裕，古賀貴子，茶谷昌宏，島田幸惠，佐藤昌史，井上美津子，高見正道
- Organizer
  第3回骨免疫学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] Administration of anti-RANKL antibody to pregnant mice results in impaired development of mammary gland and death of newborns2017
- Author(s)
  N. Sakai, N. Okamatsu, T. Koga, A. Karakawa, M Takami
- Organizer
  第65回国際歯科研究学会日本部会総会学術大会(JADR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] Administration of anti-RANKL antibody to pregnant mice results in impaired development of mammary gland and death of newborns2017
- Author(s)
  N. Sakai, N. Okamatsu, T. Koga, A. Karakawa, M Takami
- Organizer
  第65回国際歯科研究学会日本部会総会学術大会(JADR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 骨吸収抑制作用を有する抗RANKL抗体（OYC1）を投与した妊娠マウスおよびその新生仔の解析2017
- Author(s)
  坂井信裕、岡松伸明、古賀貴子、唐川亜希子、稲垣克記、高見正道
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 骨吸収抑制薬が若齢マウスの成長と歯の発育に及ぼす影響2017
- Author(s)
  井澤基樹, 唐川亜希子, 坂井信裕, 根岸貴子, 茶谷昌宏, 高見正道
- Organizer
  第35回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-17H04050
[Presentation] イムノグロブリンによる破骨細胞分化制御2016
- Author(s)
  古賀貴子
- Organizer
  第３１回日本整形外科学会
- Place of Presentation
  福岡
- Year and Date
  2016-08-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K15538
[Presentation] イムノグロブリンによる破骨細胞分化制御2016
- Author(s)
  古賀貴子
- Organizer
  第３１回日本整形外科学会
- Place of Presentation
  福岡
- Year and Date
  2016-08-31
- Invited
- Data Source
  KAKENHI-PROJECT-25293066
[Presentation] LRF regulates NFAtc1 expression in osteoclastogenesis.2010
- Author(s)
  Kaori Tsuji, Takako Koga, Takahiro Maeda, Pier Paolo Pandolfi,Keiji Moriyama, Hiroshi Takayanagi
- Organizer
  3^<rd> International Conference on Osteoimmunology
- Place of Presentation
  Santorini, Greece
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] The regulation of osteoclastogenesis by Fcy receptors2010
- Author(s)
  Takako Negishi-Koga
- Organizer
  3^<rd> International Conference on Osteoimmunology
- Place of Presentation
  Santorini, Greece
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21659428
[Presentation] Fc受容体による破骨細胞制御2010
- Author(s)
  根岸-古賀貴子
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  東京
- Year and Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] The regulation of osteoclastogenesis by Fcγ receptors 3rd2010
- Author(s)
  Takako Negishi-Koga, Hans-Jurgen Gober, Toshiyuki Takai, Hiroshi Takayanagi.
- Organizer
  International Conference on Osteoimmunology
- Place of Presentation
  Santorini, Greece
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] The regulation of osteoclastogenesis by Fcγ receptors2010
- Author(s)
  Takako Negishi-Koga
- Organizer
  3^<rd> International Conference on Osteoimmunology
- Place of Presentation
  Santorini, Greece
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] Fc受容体による破骨細胞制御2010
- Author(s)
  根岸-古賀貴子
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  東京
- Year and Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-21659428
[Presentation] Feγ Receptors Control Bone Homeostasis by Regulating Costimulation Signals in Osteoclast Lineage Cells2009
- Author(s)
  Hans-Jurgen Gober、古賀貴子、高柳広
- Organizer
  第27回日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] Tecファミリーチロシンキナーゼによる破骨細胞分化制御2008
- Author(s)
  古賀貴子, 他
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] 破骨細胞形成に必須な持続的RANKシグナルの伝達機構BMB20082008
- Author(s)
  田口祐, 合田仁, 古賀貴子, 高柳広, 井上純一郎
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] Tec kinases form an osteoclastogenic signaling complex with SLP adaptor proteins2008
- Author(s)
  Koga T, Shinohara M, Takayanagi H
- Organizer
  The 13^<th> Asia Pacific League of Associations for Rheumatology Congress
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] Tecファミリーチロシンキナーゼによる破骨細胞分化制御BMB20082008
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] Tec kinases form an OSteoclastogenic signal ing complex with SLP adaptor proteins2008
- Author(s)
  Koga T., et al.
- Organizer
  The 13th Asia Pacific League of Associations for Rheumatology Congress
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] Tec kinases form an osteoclastogenic signaling complex with SLP adaptor proteins2008
- Author(s)
  Takako Koga, Masahiro Shinohara, Hiroshi Takayanagi.
- Organizer
  13th APLAR
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-20689007
[Presentation] Tecファミリーチロシンキナーゼによる破骨細胞分化制御2008
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20689007

1. SHINOHARA Masahiro (60345733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. NAKASHIMA Tomoki (00346959)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Sakai Nobuhiro (90286849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. 高見正道 (80307058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. 岡田保典 (00115221)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. TAKAYANAGI Hiroshi (20334229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. 朝霧成挙 (20372435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 春宮覚 (50301792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐藤浩二郎 (10372434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 望月早月 (80365428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石島旨章 (70365576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 久保田光昭 (30327796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 金子晴香 (50445516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. SUZAWA Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 加藤靖正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 前田豊信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 唐川亜希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. 室龍之介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 澤新一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 新田剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 塩澤淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 岡本一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 石川紘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 上條竜太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 西尾純子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NEGISHI TAKAKO 根岸 貴子 (古賀 貴子)

古賀 貴子

古賀貴子

KOGA Takako 古賀 貴子

Research Projects

Research Products

Co-Researchers

ヒアルロン酸分解が誘導する異所性骨化・石灰化制御機構Principal Investigator

Principal Investigator

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Review Section

Research Institution

Pathophysiology and mechanism of the progression of subchondral bone lesions in knee osteoarthritis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Expression and functional analysis of hyaluronan-degrading molecule HYBID and its role in tissue destruction and repair

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lipid metabolic functions in tooth and bone homeostasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for the development of methods to control age-related diseases and bone diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Network between bone and CNSPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Development of a method for suppressing bone destruction targeting cholesterol acyltransferase.

Principal Investigator

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Research Institution

Bone metabolism by immune complexesPrincipal Investigator

Principal Investigator

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Research Institution

Post-translational modification by symmetric ariginine dimetylation in immune regulation and diseasesPrincipal Investigator

Principal Investigator

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Research Institution

The investigation of the role of bone in the regulation of neuron.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

軸策ガイダンス、セマフォリン分子による硬組織代謝細胞間制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The methylation of non-histone proteins in bone diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Osteoimmunology

NEGISHI TAKAKO 根岸貴子 (古賀貴子)

古賀貴子

KOGA Takako 古賀貴子