Okada Yasunori 岡田保典

… Alternative Names

Researcher Number	00115221
Other IDs
Affiliation (Current)	2021: 順天堂大学, 医学(系)研究科(研究院), 特任教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 順天堂大学, 医学(系)研究科(研究院), 客員教授 2017: 順天堂大学, 医学部, 客員教授 1997 – 2014: Keio University, School of Medicine, Pathology, Professor, 医学部, 教授 2007: School of Medicine, Professor 1998 – 1999: 慶応義塾大学, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Human pathology / Biological Sciences / Experimental pathology / Experimental pathology / Orthopaedic surgery / Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Experimental pathology / Human pathology / Orthopaedic surgery … More
Keywords	Principal Investigator マトリックスメタロプロテアーゼ / ADAM / 慢性関節リウマチ / 変形性関節症 / MMP / 関節軟骨破壊 / 細胞外マトリックス分解 / 分解 / 浸潤・転移 / 酵素 … More Except Principal Investigator VEGF / 浸潤 / MMP / 癌転移 / 低酸素 / 糖尿病 / 網膜症 / 転移 / 細胞外マトリックス / claudin-5 / ADAM / 血管新生 / 血液網膜関門 / Blood-retinal barrier / TIMP / がん / NM23 / 転移抑制遺伝子 / メタロプロテアーゼ / 血液脳関門 / 癌細胞増殖 / アポトーシス / 炎症 / VWF / 肺癌 / chondrocyte / MT1-MMP / Hypoxia / Fibulin-7 / 浸潤転移 / がん悪性化 / メタロプロテア-ゼ / NDPキナ-ゼ / βmアクチン / メタロプロテイナーゼ / 転移遺伝子 / 細胞外マトリックス分解酵素 / 92-kDa typeIV Collagenase / 72-kDa typeIV Collagenase / 癌 / マトリックスメタロプロテアーゼ / カルポニン / がん浸潤・転移 / マトリックス、メタロプロテアーゼ / 胎盤形成 / 転移・浸潤 / 細胞外マトリックス分解 / 膜型メタロプロテアーゼ / 転移関連遺伝子 / vWF / von Willebrand factor / ADAMTS / Yeast two-hybrid / 癌浸潤・転移 / Yeast two-hybrid法 / 癌細胞の増殖 / 骨・軟骨代謝学 / ADAM17 / TACE / 免疫学 / 骨代謝学 / Ectodomain Shedding / CSF-1 / CTGF / 乳癌 / バイオイメージング / ルシフェラーゼ / 分子標的 / 分子標的治療 / ヒト型抗体 / 骨 / 軟骨 / オステオネクチン / アミロイド / インターロイキン-1 / cartilage / osteonectin / interleukin-1 / amiroid / inflammation / コラーゲン / 接着因子 / 繊維芽細胞 / 軟骨細胞 / RGD / インテグリン / 生体材料 / 線維芽細胞 / CMP / RGD-CAP / integrin / collagen / biomatenal / 脳血管 / 個体発生 / Cerebral blood vessels / Blood-brain barrier / グリア細胞 / diabetes mellitus / retinopathy / angiogenesis / glial cell / 糖尿病網膜症 / 網膜浮腫 / 活性酸素種 / claudin / Diabetic retinopathy / Angiogenesis / Retinal edema / Claudin / Diabetus mellitus / Retinopathy / Claudin-5 / コラゲナーゼ / ゲラチナーゼ / 腎障害 / ネフローゼ症候群 / Collagenase / Gelatinase / Renal iniury / Nephrotic syndrome / 神経膠腫 / フィビュリン-7 / 組織内微小環境 / 異常血管形成 / 血管内皮細胞 / 周皮細胞 / 組織内微 / 小環境 / 腫瘍 / 血管形成 / 骨軟部組織 / 感染症 / インプラント関連感染症 / メタボローム解析 / インプラント関連感染 / 遺伝子 / 神経膠腫（グリオーマ） / ECM微小環境（ニッチ） / 細胞浸潤 / HYBID Less

Decipher cell-cell interactionsOngoing
- Principal Investigator
  
  廣畑聡
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Okayama University
Analytical study of infiltrating advanced extracellular matrix microenvironment (niche) of gliomaOngoing
- Principal Investigator
  
  デベガスサーナ
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Pathophysiological study and image analysis of early-stage knee OA by focusing on osteochondrophytesPrincipal InvestigatorOngoing
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Juntendo University
Functional analysis of fibulin-7 in glioma
- Principal Investigator
  
  de Vega Susana
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Mechanism of articular cartilage destruction in early-stage osteoarthritis and preclinical study on the development of diagnosis and treatment for early-stage osteoarthritis.Principal Investigator
- Principal Investigator
  
  Yasunori Okada
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Juntendo University
Establishment of early diagnosis and treatment in the patient with the surgical site infection
- Principal Investigator
  
  ISHII KEN
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  International University of Health and Welfare
  Keio University
Pathological study on metalloproteinases in tissue remodeling under pathological conditionsPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Research and development of human neutralizing antibodies aiming at treatment of non-small cell lung carcinoma
- Principal Investigator
  
  MOCHIZUKI Satsuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Functional analysis of ADAM28 on cancer cells by bioluminescence imaging
- Principal Investigator
  
  MOCHIZUKI Satsuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
ADAM28の癌細胞増殖・浸潤・転移における作用解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Expression of claudin-5 in brain vascular endothelial cells under hypoxia
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Yamaguchi University
  Keio University
ADAM28 cleaves von Willebrand factor and induces cancer cell metastasis
- Principal Investigator
  
  SATSUKI Mochizuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Studies of TACE in bone biology and inflammatory diseases
- Principal Investigator
  
  HORIUCHI Keisuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
ADAM28の肺癌患者におけるモニターと新規基質解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
細胞外環境モジュレーター分子ADAMの機能解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
ADAM28のヒト乳癌組織での発現と癌細胞の増殖・運動・浸潤への関与Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Molecular mechanisms underlying the retinal vascular lesions in diabetic retinopathy
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Role of collagenases and gelatinases in renal injury and their, therapeutic applications
- Principal Investigator
  
  SASAMURA Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Pathological studies on the tissue destruction by metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
ADAMTS4(aggrecanase-1)の軟骨組織内活性調節因子の網羅的探索Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Molecular mechanisms underlying the vascular lesions in proliferative diabetic retinopathy
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
膜型ADAM結合分子のクローニングと機能解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Molecular mechanisms of the pathological angiogenesis in proliferative diabetic retinopathy.
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
ヒトグリオーマの浸潤と脳細胞外マトリックス分解Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Keio University
細胞外マトリックス代謝研究の新展開の総括Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
マトリックスメタロプロテアーゼの新規機能解析Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Molecular mechanisms of the blood-brain barrier induction in cerebral blood vessels
- Principal Investigator
  
  IKEDA Eiji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Regulation of MT1-MMP gene expression by HMGI-CPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
性ホルモン依存性癌組織におけるマトリックスメタロプロテアーゼの発現Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Keio University
VEGFに結合するマトリックス成分とその分解による活性調節機構Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Molecular Pathology of Cartilage destruction in Rheumatoid ArthritisPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
性ホルモン依存性癌組織におけるストリックスメタロプロテアーゼの発現Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
Biomaterial having active sites of collagen-binding adhesion molecules (CMP and RGD-CAP)
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
がん細胞の転移と浸潤の分子生物学
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kanazawa University
細胞膜表面におけるマトリックス分解の分子機構Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
  Kanazawa University
Analyzes on ECM metabolism in transgenic and knockout micePrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Experimental pathology
- Research Institution
  School of Medicine, Keio University
  Kanazawa University
Studies on the destruction of articular cartilage by matrix metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
MMP-2(ゼラチナーゼA)の関節組織破壊における役割Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Novel factors that increase inflammation : tissue and synovial fluid levels.
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
がん細胞の浸潤性獲得の分子機構
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
慢性関節リウマチ関節破壊におけるMMP-7(pump-1)の役割Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
がん細胞の浸潤性獲得の分子機構
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
慢性関節リウマチの骨破壊に関する研究Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
がん細胞の浸潤性獲得の分子機構
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
慢性関節リウマチパンヌスに関する研究Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
慢性関節リウマチと変形性関節症におけるIX型コラ-ゲンPrincipal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
コラーゲン分解酵素とそのインヒビターの慢性関節リウマチ滑膜組織における局在Principal Investigator
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University

[Book] Kelley and Firestein's Textbook of Rheumatology.2017
- Author(s)
  Okada Y.
- Publisher
  Elsevier Inc.
- Data Source
  KAKENHI-PROJECT-16H05454
[Book] Kelley's Textbook of Rheumatology.2015
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders.
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Handbook of Proteolytic Enzymes.2013
- Author(s)
  Mochizuki S. and Okada Y.
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Kelley's Textbook of Rheumatology2013
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Handbook of Proteolytic Enzymes2013
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Publisher
  Elsevier Ltd
- Data Source
  KAKENHI-PROJECT-24590490
[Book] Handbook of Proteolytic Enzymes2013
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Total Pages
  4094
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-24590490
[Book] Handbook of Proteolytic Enzymes2013
- Author(s)
  Mochizuki S. and Okada Y.
- Publisher
  Elsevier Ltd
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Kelley's Textbook of Rheumatology.2013
- Author(s)
  Okada Y
- Publisher
  Elsevier Saunders
- Data Source
  KAKENHI-PROJECT-24249022
[Book] Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology2012
- Author(s)
  Okada Y, Firestein G. S., Budd R. C., Gabriel S. E., McInnes I. B. and O' Dell J. R
- Publisher
  Philadelphia(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Kelley's Textbook of Rheumatology, 9th edition2012
- Author(s)
  Okada Y.
- Publisher
  Proteinases and matrix degradation(In press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Handbook of Proteolytic Enzymes2012
- Author(s)
  Mochizuki S., Okada Y.
- Publisher
  ADAM28(In press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] ADAM28. In : Handbook of Proteolytic Enzymes2012
- Author(s)
  Mochizuki S. and Okada Y Rawlings N. D. and Salvesen G
- Publisher
  Elsevier Ltd(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] ADAM28.In : Handbook of Proteolytic Enzymes.2011
- Author(s)
  Mochizuki S., Okada.
- Publisher
  Elsevier Ltd, Oxford, UK.(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] 第1章MMP/TIMP pp66-68,第6章線維化pp458-460「日本血管生物医学事典」2011
- Author(s)
  望月早月、岡田保典
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21590421
[Book] Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology.2011
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders.Philadelphia, USA.(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Immunohistochemistry of MMPs and TIMPs. In Matrix Metalloproteinase Protocols2010
- Author(s)
  Okada Y
- Publisher
  Humana Press Inc
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Kelley's Textbook of Rheumatology.(Proteinases and matrix degradation.)2009
- Author(s)
  Okada Y.
- Total Pages
  19
- Publisher
  Elsevier Saunders.
- Data Source
  KAKENHI-PROJECT-19109004
[Book] In Kelley's Textbook of Rheumatology. Ed. by Firestein G. S., Budd R. C., Harris E. D., Jr., Mclnnes I. B., Ruddy s. and Sergent J. S. 8th edition. Elsevier Saunders. Philadelphia.2009
- Author(s)
  Okada Y.
- Publisher
  Proteinases and matrix degradation.
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Kelley's Textbook of Rheumatology2009
- Author(s)
  Okada Y.
- Publisher
  Elsevier Saunders
- Data Source
  KAKENHI-PROJECT-19109004
[Book] In Matrix Metalloproteinases. Ed. by Ian M. Clark. Humana Press Inc., Totowa, NJ, USA.2009
- Author(s)
  Okada Y.
- Publisher
  Immuno histochemistry of MMPs and TIMPs(in press)
- Data Source
  KAKENHI-PROJECT-19109004
[Book] Proteinases and matrix degradation.2007
- Author(s)
  Okada Y.
- Publisher
  Kelley's Textbook of Rheumatology. Ed. by Harris E. D., Jr., Budd R. C., Ruddy S., Genovese M. C., Firestein G. S. and Sargent J. S. 8th edition, Elsevier Saunders. Philadelphia,(In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Book] Proteinases and matrix degradation.(Ed. by Harris E. D., Jr., Budd R. C., Ruddy S., Genovese M.C., Firestein G. S. and Sargent J. S. 8th edition.)2007
- Author(s)
  Okada Y.
- Publisher
  Kelley's Textbook of Rheumatology. Elsevier Saunders. Philadelphia.(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Book] TIMP-1, MMP-1, α2Mとは「日本医事新報」2007
- Author(s)
  望月早月、岡田保典
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-19590404
[Book] 7th edition, Elsevier Saunders. Philadelphia2005
- Author(s)
  Okada Y.
- Publisher
  Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology. Ed. by Harris E.D., Jr., Budd R.C., Ruddy S., Genovese M.C., Firestein G.S. and Saruent J.S.
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Expression and Characterization of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization: HYBID, Alias KIAA1199 and CEMIP.2020
- Author(s)
  de Vega S, Yoshida H, Okada Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2132 Pages: 129-138
- DOI
  10.1007/978-1-0716-0430-4_1
- Data Source
  KAKENHI-PROJECT-17K08770
[Journal Article] Implication of HYBID (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) in Hyaluronan Degradation by Synovial Fibroblasts in Patients with Knee Osteoarthritis2020
- Author(s)
  Shiozawa J, de Vega S, Cilek MZ, Yoshinaga C, Nakamura T, Kasamatsu S, Yoshida H, Kaneko H, Ishijima M, Kaneko K, Okada Y.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 190 Pages: 1046-1058
- DOI
  10.1016/j.ajpath.2020.01.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09083, KAKENHI-PROJECT-17K08770
[Journal Article] Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling2019
- Author(s)
  Yoshida H.、Yamazaki K.、Komiya A.、Aoki M.、Kasamatsu S.、Murata T.、Sayo T.、Cilek M. Z.、Okada Y.、Takahashi Y.
- Journal Title
  
  International Journal of Cosmetic Science
  
  Volume: 41 Pages: 12-20
- DOI
  10.1111/ics.12505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-19H03788
[Journal Article] Fibulin‐7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin‐12019
- Author(s)
  Susana de Vega, Akihide Kondo, MarioSuzuki, Hajime Arai, Shabierjiang Jiapaer, Hemragul Sabit, Mitsutoshi Nakada, Tomoko Ikeuchi, Muneaki Ishijima, Eri Arikawa-Hirasawa, Yoshihiko Yamada and Yasunori Okada
- Journal Title
  
  Int J Cancer
  
  Volume: xx Pages: 2157-2169
- DOI
  10.1002/ijc.32306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770, KAKENHI-PROJECT-18K07535, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-18H02910
[Journal Article] Role of HYBID (Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization), Alias KIAA1199/CEMIP, in Hyaluronan Degradation in Normal and Photoaged Skin2019
- Author(s)
  Yoshida Hiroyuki、Okada Yasunori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Pages: 5804-5804
- DOI
  10.3390/ijms20225804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Inhibition of HYBID (KIAA1199)-mediated hyaluronan degradation and anti-wrinkle effect of Geranium thunbergii extract2019
- Author(s)
  Yoshida Hiroyuki、Yamazaki Kohei、Komiya Aya、Aoki Mika、Nakamura Tomomi、Kasamatsu Shinya、Murata Takeshi、Sayo Tetsuya、Okada Yasunori、Takahashi Yoshito
- Journal Title
  
  Journal of Cosmetic Dermatology
  
  Volume: - Pages: 1052-1060
- DOI
  10.1111/jocd.12813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-19H03788
[Journal Article] 変形性膝関節症における慢性疼痛2019
- Author(s)
  石島旨章、金子晴香、根岸義文、百枝雅裕、岡田保典、金子和夫
- Journal Title
  
  日本臨床
  
  Volume: 77 Pages: 2027-2034
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis.2019
- Author(s)
  Sadatsuki Ryo、Ishijima Muneaki、Kaneko Haruka、Liu Lizu、Futami Ippei、Hada Shinnosuke、Kinoshita Mayuko、Kubota Mitsuaki、Aoki Takako、Takazawa Yuji、Ikeda Hiroshi、Okada Yasunori、Kaneko Kazuo
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 37 Pages: 529-536
- DOI
  10.1007/s00774-018-0950-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-18K09083
[Journal Article] 変形性膝関節症におけるHYBID（CEMIP/KIAA1199）の発現と役割―早期変形性膝関節症のバイオマーカーとしての可能性も含めてー2019
- Author(s)
  塩澤淳, 石島旨章, 金子和夫, 岡田保典
- Journal Title
  
  整形・災害外科
  
  Volume: 62 Pages: 1519-1525
- Data Source
  KAKENHI-PROJECT-19H03788
[Journal Article] Relationship of hyaluronan and HYBID (KIAA1199) expression with roughness parameters of photoaged skin in Caucasian women2018
- Author(s)
  Yoshida H.、Komiya A.、Ohtsuki R.、Kusaka-Kikushima A.、Sakai S.、Kawabata K.、Kobayashi M.、Nakamura S.、Nagaoka A.、Sayo T.、Okada Y.、Takahashi Y.
- Journal Title
  
  Skin Research and Technology
  
  Volume: 24 Pages: 562-569
- DOI
  10.1111/srt.12467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Reduction of hyaluronan and increased expression of HYBID (alias CEMIP and KIAA1199) correlate with clinical symptoms in photoaged skin2018
- Author(s)
  Yoshida H., Nagaoka A., Komiya A., Aoki M., Nakamura S., Morikawa T., Ohtsuki R., Sayo T., Okada Y. and Takahashi Y.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: in press Pages: 136-144
- DOI
  10.1111/bjd.16335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Is Up-Regulated and Involved in Hyaluronan Degradation in Human Osteoarthritic Cartilage2018
- Author(s)
  Shimizu H, Shimoda M, Mochizuki S, Miyamae Y, Abe H, Chijiiwa M, Yoshida H, Shiozawa J, Ishijima M, Kaneko K, Kanaji A, Nakamura M, Toyama Y, Okada Y.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 188 Pages: 2109-2119
- DOI
  10.1016/j.ajpath.2018.05.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10941, KAKENHI-PROJECT-18K07052, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-16K08719
[Journal Article] Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation2018
- Author(s)
  Yoshino Yuta、Shimazawa Masamitsu、Nakamura Shinsuke、Inoue Shintaro、Yoshida Hiroyuki、Shimoda Masayuki、Okada Yasunori、Hara Hideaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Pages: 1934-1940
- DOI
  10.1016/j.bbrc.2018.07.138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-16J11526, KAKENHI-PROJECT-16K08719
[Journal Article] Hyaluronan-binding protein involved in hyaluronan depolymerization controls endothelial ossification through hyaluronan metabolism.2017
- Author(s)
  Shimoda M., Yoshida H., Mizuno S., Hirozane T., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 187 Pages: 1162-1176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system.2017
- Author(s)
  Yuta Yoshino, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hiroyuki Yoshida, Shintaro Inoue, Masayuki Shimoda, Yasunori Okada, Hideaki Hara
- Journal Title
  
  Neuroscience
  
  Volume: 347 Pages: 1-10
- DOI
  10.1016/j.neuroscience.2017.01.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11526, KAKENHI-PROJECT-16H05454
[Journal Article] HYBID (hyaluronan binding protein involved in hyaluronan depolymerization, KIAA1199) controls endochondral ossification through hyaluronan metabolism2017
- Author(s)
  Shimoda M., Yoshida H., Mizuno S., Hirozane T., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.
- Journal Title
  
  Am J Pathol.
  
  Volume: 187 Pages: 1162-1176
- DOI
  10.1016/j.ajpath.2017.01.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-16J02900, KAKENHI-PROJECT-16J11526, KAKENHI-PROJECT-16K08719, KAKENHI-PROJECT-15K10494
[Journal Article] Imaging comparison between Chinese and Japanese patients with cervical ossification of the posterior longitudinal ligament2017
- Author(s)
  Xiao B, Nagoshi N, Takeuchi A, Mao J, Liu B, Tian W, Tsuji O, Okada E, Fujita N, Yagi M, Nakamura M, Matsumoto M, Ishii K, Watanabe K
- Journal Title
  
  Spine
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10457
[Journal Article] Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis2017
- Author(s)
  Hada S., Ishijima M., Kaneko H., Kinoshita M., Liu L., Sadatusuki R., Futami I., Yusup A., Takamura T., Arita H., Shiozawa J., Aoki T., Takazawa Y., Ikeda H., Aoki S., Kurosawa H., Okada Y. and Kaneko K.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 19 Pages: 201-201
- DOI
  10.1186/s13075-017-1411-0
- NAID
  40021621180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-15K10494, KAKENHI-PROJECT-15K20019, KAKENHI-PROJECT-16K20069
[Journal Article] Osteoarthritis as a cause of locomotive syndrome: Its influence on functional mobility and activities of daily living.2016
- Author(s)
  Ishijima M., Kaneko H., Hada S., Kinoshita M., Sadatsuki R., Liu L., Shimura Y., Arita H., Shiozawa J., Yusup A., Futami I., Sakamoto Y., Ishibashi M., Machida S., Naito H., Arikawa-Hirasawa E., Hamada C., Saita Y., Takazawa Y., Ikeda H., Okada Y. and Kaneko K
- Journal Title
  
  Clinic Rev Bone Miner Metab
  
  Volume: 14 Pages: 77-104
- DOI
  10.1007/s12018-016-9212-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05454
[Journal Article] A Retrospective Cohort Study Comparing the Safety and Efficacy of Minimally Invasive Versus Open Surgical Techniques in the Treatment of Spinal Metastases2016
- Author(s)
  Hikata T, Isogai N, Shiono Y, Funao H, Okada E, Fujita N, Iwanami A, Watanabe K, Tsuji T, Nakamura M, Matsumoto M, Ishii K
- Journal Title
  
  Clin Spine Surg
  
  Volume: 00 Pages: 1-6
- DOI
  10.1097/bsd.0000000000000460
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10457
[Journal Article] Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation2016
- Author(s)
  Shimoda M, Horiuchi K, Sasaki A, Tsukamoto T, Okabayashi K, Hasegawa H, Kitagawa Y and Okada Y
- Journal Title
  
  EBioMedicine
  
  Volume: 5 Pages: 114-124
- DOI
  10.1016/j.ebiom.2016.02.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860276, KAKENHI-PROJECT-16H05454, KAKENHI-PROJECT-15K08960
[Journal Article] Development of human antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).2016
- Author(s)
  Aya Shiraishi, Satsuki Mochizuki, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 469 Pages: 114-124
- DOI
  10.1016/j.bbrc.2015.11.072
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08409, KAKENHI-PROJECT-16H05454
[Journal Article] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.2015
- Author(s)
  Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama Y. and Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke.2015
- Author(s)
  Ishida M., Mikami S., Shinojima T., Kosaka T., Mizuno R., Kikuchi E., Miyajima A., Okada Y. and Oya M.
- Journal Title
  
  Int J Cancer
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity2015
- Author(s)
  Miyuki Chijiiwa, Satsuki Mochizuki, Tokuhiro Kimura, Hitoshi Abe, Yukie Tanaka,Yutaka Fujii, Hidenori Shimizu, Hiroyuki Enomoto, Yoshiaki Toyama and Yasunori Okada
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- DOI
  10.1002/art.39078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590490
[Journal Article] Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.2015
- Author(s)
  Anzai A., Shimoda M., Endo J., Kohno T., Katsumata ., Matsuhashi T., Yamamoto T., Ito K., Yan X., Shirakawa K., Shimizu-Hirota R., Yamada Y., Ueha S., Shinmura K., Okada Y., Fukuda K. and Sano M.
- Journal Title
  
  Circ Res
  
  Volume: 116 Pages: 612-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.2015
- Author(s)
  Mikami S., Mizuno R., Kosaka T., Saya H., Oya M. and Okada Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Pages: 1504-1514
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Heat-induced antigen retrieval in conventionally processed epon-embedded specimens: procedures and mechanisms.2014
- Author(s)
  Yamashita S. and Okada Y.
- Journal Title
  
  J Hictochem Cytochem
  
  Volume: 62 Pages: 584-597
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Invasion and metastasis of renal cell carcinoma.2014
- Author(s)
  Mikami S., Oya M., Mizuno R., Kosaka T., Katsube K. I. and Okada Y.
- Journal Title
  
  Med Mol Morphol
  
  Volume: 47 Pages: 63-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Loss of the TIMP gene family is sufficient for the acquisition of the CAF-like cell state.2014
- Author(s)
  Shimoda M., Principe S., Jackson H.W., Luga V., Fang H., Molyneux S.D., Shao Y.W., Aiken A., Waterhouse P.D., Karamboulas C., Hess F.M., Ohtsuka T., Okada Y., Ailles L., Ludwig A., Wrana J.L., Kislinger T. and Kohkha R.
- Journal Title
  
  Nat Cell Biol
  
  Volume: 16 Pages: 889-901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Conditional Inactivation of TNFalpha-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones2013
- Author(s)
  Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K
- Journal Title
  
  PLOS One
  
  Volume: 8(1)
- DOI
  10.1371/journal.pone.0054853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] Mechanisms of angiogenic suppression in uteri exposed to diethylstilbestrol neonatally in the mouse.2013
- Author(s)
  Yamashita S., Kudo A., Kawakami H. and Okada Y.
- Journal Title
  
  Biol Reprod
  
  Volume: 88 Pages: 1-13
- DOI
  10.1095/biolreprod.112.106443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.2013
- Author(s)
  Abe H., Mochizuki S., Ohara K., Ueno M., Ochiai H., Kitagawa Y., Hino O., Sato H. and Okada Y.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 183 Pages: 1667-1678
- DOI
  10.1016/j.ajpath.2013.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] HMGA2 is a driver of tumor metastasis.2013
- Author(s)
  Morishita A., Zaidi M. R., Mitoro A., Sankarasharma D., Szabolcs M., Okada Y., D'Armiento J. and Chada K.
- Journal Title
  
  Cancer Res
  
  Volume: 73 Pages: 4289-4299
- DOI
  10.1158/0008-5472.can-12-3848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Systemic Overexpression of TNFalpha-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo2013
- Author(s)
  Yoda M, Kimura T, Tohmonda T, Morioka H, Matsumoto M, Okada Y, Toyama Y, Horiuchi K
- Journal Title
  
  PLOS One
  
  Volume: 8(1)
- DOI
  10.1371/journal.pone.0054412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.2013
- Author(s)
  Yoshida H., Nagaoka A., Kusaka-Kikushima A., Tobiishi M., Kawabata K., Sayo T., Sakai S., Sugiyama Y., Enomoto H., Okada Y. and Inoue S.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110 Pages: 5612-5617
- DOI
  10.1073/pnas.1215432110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer2013
- Author(s)
  Kosaka T, Miyazaki Y, Miyajima A, Mikami S, Hayashi Y, Tanaka N, Nagata H, Kikuchi E, Nakagawa K, Okada Y, Sato Y, Oya M
- Journal Title
  
  Br J Cancer
  
  Volume: 108 Pages: 2123-2129
- DOI
  10.1038/bjc.2013.169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
[Journal Article] Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis.2013
- Author(s)
  Nkyimbeng T., Ruppert C., Shiomi T., Dahal B.K., Lang G., Seeger W., Okada Y., D´Armiento J. and Gunther A.
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0073279
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization.2013
- Author(s)
  Yoshida H., Nagaoka A., Nakamura S., Okada Y. and Inoue S.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 3 Pages: 352-356
- DOI
  10.1016/j.fob.2013.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma2013
- Author(s)
  Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya.
- Journal Title
  
  Br J Cancer.
  
  Volume: 108 Pages: 2312-20
- DOI
  10.1038/bjc.2013.216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791784, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
[Journal Article] ADAM282012
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Journal Title
  
  Handbook of Proteolytic Enzymes
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Effect of ADAM28 on Carcinoma Cell Metastasis by Cleavage of von Willebrand Factor2012
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda, Hitoshi Abe, Aya Sasaki, Hirotaka James Okano, Hideyuki Okano, Yasunori Okada
- Journal Title
  
  J. Natl. Cancer Inst
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Regulatory role of dendritic cells in post-infarction healing and left ventricular remodeling2012
- Author(s)
  Anzai A, Fukuda K, et al
- Journal Title
  
  Circulation
  
  Volume: 125(10) Pages: 1234-1245
- DOI
  10.1161/circulationaha.111.052126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249051, KAKENHI-PROJECT-23390217, KAKENHI-PROJECT-23790875, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling2012
- Author(s)
  Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, Yuichiro Maekawa, Kotaro Naito, Hidehiro Kaneko, Yasuo Sugano, Toshiyuki Takahashi, Hitoshi Abe, Satsuki Mochizuki, Motoaki Sano, Tsutomu Yoshikawa, Yasunori Okada, Shigeo Koyasu, Satoshi Ogawa, and Keiichi Fukuda
- Journal Title
  
  Circulation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection2012
- Author(s)
  Kurihara T., Shimizu-Hirota R., Shimoda M., Adachi T., Shimizu H., Weiss S. J., Itoh H., Hori S., Aikawa N. and Okada Y
- Journal Title
  
  Circulation
  
  Volume: 126 Pages: 3070-3080
- DOI
  10.1161/circulationaha.112.097097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand Factor2012
- Author(s)
  Satsuki Mochizuki
- Journal Title
  
  J Natl Cancer Inst
  
  Volume: 104(In press) Pages: 906-922
- DOI
  10.1093/jnci/djs232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] Enhanced susceptibility to 1 ipopolysaccharide-induced arthritis and end otoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012
- Author(s)
  Nakayama M., Niki Y., Kawasaki T., Takeda Y., Horiuchi K., Sasaki A., Okada Y., Umezawa K., Ikegami H., Toyama Y. and Miyamoto T.
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 14
- DOI
  10.1186/ar3850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24592280
[Journal Article] Regulation of monocyte-chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer.2012
- Author(s)
  Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M
- Journal Title
  
  Am J Pathol
  
  Volume: 180(3) Pages: 1008-1016
- DOI
  10.1016/j.ajpath.2011.11.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-23791785, KAKENHI-PROJECT-24249022
[Journal Article] Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor2012
- Author(s)
  Mochizuki S., Soejima K., Shimoda M., Abe H., Sasaki A., Okano H. J., Okano H. and Okada Y
- Journal Title
  
  J. Natl. Cancer Inst
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] High-mobility group box 1 protein blockade suppresses development of abdominal aortic aneurysm2012
- Author(s)
  Kohno T., Anzai T., Kaneko H., Sugano Y., Shimizu H., Shimoda M., Miyasho T., Okamoto M., Yokota H., Yamada S., Yoshikawa T., Okada Y., Yozu R., Ogawa S. and Fukuda K
- Journal Title
  
  J Cardiol
  
  Volume: 59 Pages: 299-306
- DOI
  10.1016/j.jjcc.2012.01.007
- NAID
  10031187749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] ADAM28 is elevated with the metabolic syndrome and is a sheddase of human tumour necrosis factor2012
- Author(s)
  Jowett J.B.M., Okada Y., Leedman P.J., Curran J.E., Johnson M.P., Moses E.K., Goring H.H.H., Mochizuki S., Blangero J., Stone L., Allen H., Mitchell C. and Matthews V.B
- Journal Title
  
  Immunology & Cell Biology
  
  Volume: 90 Pages: 966-973
- DOI
  10.1038/icb.2012.44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490
[Journal Article] Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy2012
- Author(s)
  Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 53 Pages: 4055-4062
- DOI
  10.1167/iovs.12-9857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592588, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490, KAKENHI-PROJECT-24592647
[Journal Article] Regulatory role of dendritic cells in post-infarction healing and left ventricular remodeling2011
- Author(s)
  Anzai A., Anzai T., Nagai S., Maekawa Y., Naito K., Kaneko H., Sugano Y., Takahashi T., Abe H., Mochizuki S., Sano M., Yoshikawa T., Okada Y., Koyasu S., Ogawa S., Fukuda K.
- Journal Title
  
  Circulation
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necross factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Morimoto K., Anzai A., Nagai T., Sugano Y., Maekawa Y., Itoh H., Yoshikiwa T., Okada Y., Ogawa S., Fukuda K.
- Journal Title
  
  Cirulation J
  
  Volume: 75 Pages: 2482-2490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Resveratrol prevents development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization2011
- Author(s)
  Kaneko H., Anzai T., Morisawa M., Kohno T., Nagai T., Anzai A., Takahashi T., Shimoda M., Sasaki A., Maekawa Y., Yoshimura K., Aoki H., Tsubota K., Yoshikawa T., Okada Y., Ogawa S., Fukuda K.
- Journal Title
  
  Atherosclerosis
  
  Volume: 217 Pages: 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Kohno T., Nagai T., Anzai A., Takahashi T., Sasaki A., Shimoda M., Maekawa Y., Shimizu H., Yoshikawa T., Okada Y., Yozu R., Fukuda K.
- Journal Title
  
  Atherosclerosis
  
  Volume: 218 Pages: 470-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Hiroki Fukuda, Satsuki Mochizuki, Hitoshi Abe, Hirotaka James Okano, Chikako Hara-Miyauchi, Hideyuki Okano, Noriko Yamaguchi, Mitsuo Nakayama, Jeanine D' Armiento and Yasunori Okada
- Journal Title
  
  Br. J. Cancer
  
  Volume: 105 Pages: 1615-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Expression of Snail and Slug in renal cell carcinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis2011
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mukai M. and Okada Y
- Journal Title
  
  Lab. Invest
  
  Volume: 91 Pages: 1443-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necross factor-αconverting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Morimoto K., Anzai A., Nagai T., Sugano Y. Maekawa Y., Itoh H., Yoshikiwa T., Okada Y., Ogawa S. and Fukuda K
- Journal Title
  
  Cirulation J
  
  Volume: 75 Pages: 2482-2490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Dual functions of cell-autonomous and non cell-autonomous ADAM10 activity in granulopoiesis2011
- Author(s)
  Yoda M., Kimura T., Link D.C., Chiba K., Okada Y., Matsumoto M., Toyama Y., Horiuchi K.
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6939-6942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_(165)-promoted chondrocyte migration : an implication for chondrocyte cloning2011
- Author(s)
  Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y. and Okada Y
- Journal Title
  
  Arthr itis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm2011
- Author(s)
  Kaneko H., Anzai T., Takahashi T., Kohno T., Shimoda M., Sasaki A., Shimizu H., Nagai T., Maekawa Y., Yoshimura K., Aoki H., Yoshikawa T., Okada Y., Yozu R., Ogawa S., Fukuda K.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 91 Pages: 358-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts2011
- Author(s)
  Kawakami T., Sameshima T., Hojo H., Koga K., Nakahara Y., Toole B.P., Okada Y., Iwasaki A., Nabeshima K.
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Pages: 300-300
- DOI
  10.1186/1471-2407-11-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004, KAKENHI-PROJECT-23380065
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Fukuda H., Mochizuki S., Abe H., Okano H. J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D' Armiento J. and Okada Y
- Journal Title
  
  Br J Cancer
  
  Volume: 105 Pages: 1615-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Tumor necrosis factor-αconverting enzyme is a key mediator of abdominal aortic aneurysm development2011
- Author(s)
  Kaneko H., Anzai T., Horiuchi K., Kohno T., Nagai T., Anzai A., Takahashi T., Sasaki A., Shimoda M., Maekawa Y., Shimizu H., Yoshikawa T., Okada Y., Yozu R. and Fukuda K
- Journal Title
  
  Atherosclerosis
  
  Volume: 218 Pages: 470-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells2011
- Author(s)
  Shirakabe K., Hattori S., Seiki M., Koyasu S., Okada Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 43154-43163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_<165>-promoted chondrocyte migration : an implication for chondrocyte cloning2011
- Author(s)
  Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Fukuda H., Mochizuki S., Abe H., Okano H.J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D'Armiento J., Okada Y.
- Journal Title
  
  Brit J Cancer
  
  Volume: 105 Pages: 1615-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of Snail arid Slug in renal cell carcinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis2011
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mukai M., Okada Y.
- Journal Title
  
  Lab Invest
  
  Volume: 91 Pages: 1443-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor 165-promoted chondrocyte migration2011
- Author(s)
  Masashi Okubo, Tokuhiro Kimura, Yoshinari Fujita, Satsuki Mochisuki, Yasuo Niki, Enomoto H, Yasunori Suda, Yoshiaki T and Yasunori Okada
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Connective tissue growth factor is a substrate of ADAM282010
- Author(s)
  Mochizuki, S., Tanaka R., Shimoda M., Onuma J., Fujii Y., Jinno H. and Okada Y
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 651-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Connective tissue growth factor is a substrate of ADAM282010
- Author(s)
  Satsuki Mochizuki, Rena Tanaka, Masayuki Shimoda, Junko Onuma, Yutaka Fujii, Hiromitsu Jinno and Yasunori Okada
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 651-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] Expression of snail in upper urinary tract urothelial carcinoma : prognostic significance and implications for tumor invasion2010
- Author(s)
  Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 5814-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression of snail in upper urinary tract urothelial carcinoma : prognostic significance and implications for tumor invasion.2010
- Author(s)
  Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 5814-5823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage.2010
- Author(s)
  Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M., Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents2010
- Author(s)
  Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S. and Fukuda, K
- Journal Title
  
  J. Clin. Invest
  
  Volume: 120 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.2010
- Author(s)
  Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S., Fukuda, K.
- Journal Title
  
  J Clin Invest
  
  Volume: 120 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.2010
- Author(s)
  Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K., Okada Y.
- Journal Title
  
  Int J Cancer (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Production and activation of matrix metalloproteinase-7 (matrilysin-1) in the lungs of patients with idiopathic pulmonary fibrosis.2010
- Author(s)
  Fujishima S., Shiomi T., Yamashita S., Yogo Y., Nakano Y., Inoue T., Nakamura M., Tasaka S., Hasegawa N., Aikawa N., Ishizaka A., Okada Y.
- Journal Title
  
  Arch.Pathol.Lab.Med.
  
  Volume: 134 Pages: 1136-1142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers2010
- Author(s)
  Hiroaki Kuroda, Satsuki Mochizuki, Masayuki Shimoda, Miyuki Chijiiwa, Kazunori Kamiya, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Masahumi Kawamura, Koichi Kobayashi and Yasunori Okada
- Journal Title
  
  Int. J. Cancer
  
  Volume: 127 Pages: 1844-1856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421
[Journal Article] MMPs, ADAMs and ADAMTSs in non-neoplastic diseases.2010
- Author(s)
  Shiomi T., Lemaitre V., D'Armiento J., Okada Y.
- Journal Title
  
  Pathol.Int.
  
  Volume: 60 Pages: 477-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.2010
- Author(s)
  Stokes A., Joutsa J.T., Ala-aho R., Pitchers M., Pennington C.J., Martin C., Premachandra D.J., Okada Y., Peltonen J., Grenman R., James H.A., Edwards D.R., Kahari V-M
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 2022-2035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers2010
- Author(s)
  Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K. and Okada Y
- Journal Title
  
  Int. J. Cancer
  
  Volume: 127 Pages: 1844-1856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis.2010
- Author(s)
  Sakamaki Y., Sasamura H., Hayashi K., Ishiguro K., Takaishi H., Okada Y., D'Armiento J., Saruta T., Itoh H.
- Journal Title
  
  Nephron Exp Nephrology
  
  Volume: 115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.2010
- Author(s)
  Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K., Okada Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 127 Pages: 1844-1856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Activation of the Aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.2010
- Author(s)
  Ishida M., Mikami S., Kikuchi E., Kosaka T., Miyajima A., Nakagawa K., Mukai M., Okada Y., Oya M.
- Journal Title
  
  Carcinogenesis
  
  Volume: 31 Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage2010
- Author(s)
  Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M. and Okada Y
- Journal Title
  
  Am. J. Pathol
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Connective tissue growth factor is a substrate of ADAM28.2010
- Author(s)
  Mochizuki, S., Tanaka R., Shimoda M., Onuma J., Fujii Y., Jinno H., Okada Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 402 Pages: 651-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing2009
- Author(s)
  Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D' Armiento J. and Okada Y
- Journal Title
  
  Am. J. Pathol
  
  Volume: 175 Pages: 533-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 as a target for human cancers2009
- Author(s)
  Mochizuki S. and Okada Y
- Journal Title
  
  Cur r. Pharm. Des
  
  Volume: 15 Pages: 2349-2358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009
- Author(s)
  Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
- Journal Title
  
  Am.J.Pathol. 175
  
  Pages: 533-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y. Blobel CP, Toyama Y
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, and Toyama Y
- Journal Title
  
  J. Immunol
  
  Volume: 182 Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RANKL expression in clear cell renal cel carcinomas andits association with bone metastasis and cancer cell migration2009
- Author(s)
  Shuji Mikami, Ken-ichi Katsube, MototsuguOya, Satsuki Mochizuki, Masayuki Shimoada, Ryuichi Mizuno, Masaru Ishida, Tohru Ikeda, Makio Mukai, and Yasunori Okada
- Journal Title
  
  J. Urology (In press)
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] ADAM28 as a target for human cancers.2009
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Curr.Pharm.Des. 15
  
  Pages: 2349-2358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013040
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes2009
- Author(s)
  Yatabe T., Mochizuki S., Takizawa M., Chijiiwa M., Okada A., Kimura T., Fujita Y., Matsumoto H., Toyama Y. and Okada Y
- Journal Title
  
  Ann. Rheum. Dis
  
  Volume: 68 Pages: 1051-1058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas2009
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mochizuki S., Ikeda T., Mukai M. and Okada Y.
- Journal Title
  
  J Pathol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013040
[Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.2009
- Author(s)
  Hikata T, Takaishi H, Takito J, Hakozaki A, Furukawa M, Uchikawa S, Kimura T, Okada Y, Matsumoto M, Yoshimura A, Nishimura A, Reddy S V, Asahara H, Toyama Y.
- Journal Title
  
  Blood 113
  
  Pages: 2202-2212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi, K, T. Kimura, T. Miyamoto, K. Miyamoto, H. Akiyama, H. Takaishi, H. Morioka, T. Nakamura, Y. Okada, C. P. Blobel and Y. Toyama.
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes2009
- Author(s)
  Taku Yatabe, Satsuki Mochizuki, Masayuki Takizawa, Miyuki Chijiiwa, Aiko Okada, Tokuhiro Kimura, Yoshinari Fujita, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
- Journal Title
  
  Ann. Rheum. Dis 68
  
  Pages: 1051-1058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] ADAM28 as therapeutic target2009
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Journal Title
  
  Curr. Pharm. Design In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1)in humanosteoarthritic chondrocytes.2009
- Author(s)
  Yatabe T., Mochizuki S., Takizawa M. Chijiiwa M., Okada A., Kimura T., Fujita Y. Matsumoto H., Toyama Y, Okada Y.
- Journal Title
  
  Ann Rheum Dis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 as a target for human cancers.2009
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Curr.Pharm.Des. 15
  
  Pages: 2349-2358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas2009
- Author(s)
  Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mochizuki S., Ikeda T., Mukai M. and Okada Y
- Journal Title
  
  J. Pathol
  
  Volume: 218 Pages: 530-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009
- Author(s)
  Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
- Journal Title
  
  Am. J.Pathol 175
  
  Pages: 533-546
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM12 (Meltrin a) is involved in chondrocyte proliferation viacleavage of insulin-like growth factor-binding protein-5 in osteoarthriticcartilage.2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y., Okada Y.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aagrecanase-1) in osteoarthritic chondrocyte2008
- Author(s)
  Masayuki Takizawa, Taku Yatabe, Aiko Okada, Miyuki Chijiiwa, Satsuki Mochizuki, Peter Ghosh and Yasunori Okada
- Journal Title
  
  FEBS Lett 582
  
  Pages: 2945-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes2008
- Author(s)
  Takizawa M., Yatabe T., Okada A., Chijiiwa M., Mochizuki S., Ghosh P. and Okada Y
- Journal Title
  
  FEBS Lett
  
  Volume: 582 Pages: 2945-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos2008
- Author(s)
  Ikeda E., Kodama T. Okada Y.
- Journal Title
  
  Dev. Neurosci. 30
  
  Pages: 31-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis2008
- Author(s)
  Kimura N., Shukunami C., Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin' oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. and Fukuda K
- Journal Title
  
  Circulation
  
  Volume: 118 Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Purification of matrix metalloproteinases by column chromatography.2008
- Author(s)
  Imai, K. and Okada Y.
- Journal Title
  
  Nat Protoc. (in press)
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Expression of heparanase in renal cell carcinomas : Implications for tumor invasion and progression2008
- Author(s)
  Mikami S., Oya M., Shimoda M., Mizuno R., Ishida M., Kosaka T., Mukai M., Nakajima M. and Okada Y.
- Journal Title
  
  Clin Cancer Res 14
  
  Pages: 6055-6061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013040
[Journal Article] ADAM-12 (meltrin-α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage2008
- Author(s)
  Aiko Okada, Satsuki Mochizuki, Taku Yatabe, Tokuhiro Kimura, Takayuki Shiomi, Yoshinari Fujita, Hideo Matsumoto, Atsuko Sehara-Fujisawa, Yukihide Iwamoto, Yasunori Okada
- Journal Title
  
  Arthritis Rhum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] ADAM12 (Meltrin α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor-binding protein-5 in osteoarthritic cartilage2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y. and Okada Y
- Journal Title
  
  Arthritis Rheum
  
  Volume: 58 Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Purification of matrix metalloproteinases by column chromatography2008
- Author(s)
  Imai, K. and Okada Y
- Journal Title
  
  Nat. Protoc
  
  Volume: 3 Pages: 1111-1124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM-12(meltrin-α)is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding Protein 5 in osteoarthritic cartilage2008
- Author(s)
  岡田愛子(望月早月:2番目/10名)
- Journal Title
  
  Arthritis&Rhumatsm 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Expression of heparanase in renal cell carcinomas: Implications for tumor invasion and progression.2008
- Author(s)
  Mikami S., Oya M., Shimoda M., Mizuno R., Ishida M., Kosaka T., Mukai M., Nakajima M. Okada Y.
- Journal Title
  
  Clin. Cancer Res. 14
  
  Pages: 6055-6061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.2008
- Author(s)
  Takizawa M., Yatabe T., Okada A., Chijiiwa M., Mochizuki S., Ghosh P., Okada Y.
- Journal Title
  
  FEBS Lett 582
  
  Pages: 2945-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM12 (Meltrin A) is involved in chondrocyte proliferation via cleavageofinsulin-like growth factor-binding protein-5 in osteoarthritic cartilage.2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kinrnra T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y. and Okada Y.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteninase activation are associated with the rupture of the chordae tendineae cordis.2008
- Author(s)
  Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G, Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. Fukuda K.
- Journal Title
  
  Circulation 118
  
  Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Purification of matrix metalloproteinases by column chromatography.2008
- Author(s)
  Imai, K., Okada Y.
- Journal Title
  
  Nat Protoc 3
  
  Pages: 1111-1124
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.2008
- Author(s)
  Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. And Fukuda K.
- Journal Title
  
  Circulation 118
  
  Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase 13 (MMP-13) deficient mice.2007
- Author(s)
  Kosaki N., Takaishi H, Kamekura S., Kimura.T., Okada Y., Minqi L., Amizuka N., Chung U., Nakamura.K., Kawaguchi H., Toyama Y., D'Armiento J.
- Journal Title
  
  Bichem. Biophys. Res. Commun (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Cutting Edge : TNF-α-Converting Enzyme (TACE/ADAM17) Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock2007
- Author(s)
  Horiuchi, K., T. Kimura, T. Miyamoto, H. Takaishi, Y. Okada, Y. Toyama, and C. P. Blobel
- Journal Title
  
  J Immunol 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Satsuki Mochizuki and Yasunori Okada
- Journal Title
  
  Cancer Sci 98
  
  Pages: 621-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Joint diseases and matrix metalloproteinases: A role for MMP-13.2007
- Author(s)
  Takaishi H., Kimura T, Dalal S., Okada Y. and D'Anniento J.
- Journal Title
  
  Curr. Phann. Biotechnol. 9
  
  Pages: 47-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] TNFα-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock2007
- Author(s)
  Horiuchi K., Kimura T., Miyamoto T., Takaishi H., Okada Y., Toyama Y. and Blobel C. P
- Journal Title
  
  J. Immunol
  
  Volume: 179 Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Proteinases and matrix degradation.2007
- Author(s)
  Okada Y.
- Journal Title
  
  Kelley's Textbook of Rheumatology. Ed. by Harris E. D., Jr., Budd R. C., Ruddy S., Genovese M.C., Firestein G S. and Sargent J. S. 8th edition, Elsevier Saunders. Philadelphia (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Joint diseases and matrix metalloproteinases : A role for MMP-13.2007
- Author(s)
  Takaishi H., Kimura T., Dalai S., Okada Y, D'Armiento J
- Journal Title
  
  Cur. Pharma. Biotechonol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.2007
- Author(s)
  Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S., Okada Y.
- Journal Title
  
  J.Biol. Chem. 282
  
  Pages: 25864-25874
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase 13 (MMP-13) deficient mice.2007
- Author(s)
  Kosaki N., Takaishi H., Kamekura S., Kimura T., Okada Y, Minqi L., Amizuka N., Chung U., Nakamura K., Kawaguchi H., Toyama Y, D'Armiento J
- Journal Title
  
  Bichem. Biophys. Res. Commun. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase 13 (MMP-13) deficient mice.2007
- Author(s)
  Kosaki N, Takaishi H, Kamekura S, Kimura T, Okada Y, Minqi L, Amizuka N, Chung U, Nakamura K, Kawaguchi H, Toyama Y, D'Armiento J.
- Journal Title
  
  Bichem. Biophys. Res. Commun (In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membranetype 1-MMP-dependent tumor growth in mice.2007
- Author(s)
  TaniWakiK., Fukamachi H., Ko moriK., Ohtake Y., Nonaka T., Sakamoto T., Shiomi X, OkadaY., Itoh T., Itohara S., Seiki M.and Yana I.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 4311-4319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Hypoxia disturbs the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.2007
- Author(s)
  Koto T., Takubo K., Ishida S., Shinoda H., Inoue M., Tsubota K., Okada Y. and Ikeda E.
- Journal Title
  
  Am. J. Pathol. 170
  
  Pages: 1389-1397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.2007
- Author(s)
  Shimoda M., Hashimoto G, Mochizuki S., Dceda E., Nagai N., Ishida S. and Okada Y.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis2007
- Author(s)
  Kobayashi A., Okazaki S., Enomoto H., Shiomi T., Obata K. and Okada Y
- Journal Title
  
  Arch. Pathol. Lab. Med
  
  Volume: 131 Pages: 563-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAMs in cancer cell proliferation and progression.2007
- Author(s)
  Mochizuki S. and Okada Y
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 621-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] TNF A-converting enzyme (TACE/ADAM17) inactivation in mousemyeloid cells prevents lethality from endotoxin shock.2007
- Author(s)
  Horiuchi K., Kimura T., Miyamoto T., Takaishi H., Okada Y, Toyama Y. and Blobel C.P.
- Journal Title
  
  J. Immunol. 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Predominant expression of 0LIG2 over ID2 is a useful predictive indexof chemosensitive gliomas.2007
- Author(s)
  Mikami S., Hirose Y., YoshidaK., Kawase T., Ohnishi A., Nagashima K., Okada Y. and IkedaE.
- Journal Title
  
  Virchows Arch 450
  
  Pages: 575-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.2007
- Author(s)
  Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
- Journal Title
  
  Am J Pathol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590317
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Cancer Sci. (In press)
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells2007
- Author(s)
  Masayuki Shimoda, Gakuji Hashimoto, Satsuki Mochizuki, Eiji Ikeda, Norihiro Nagai, Susumu Ishida and Yasunori Okada
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590404
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to 。dothelial cells.2007
- Author(s)
  Shimoda M., Hashimoto G, Mochizuki S., Dceda E., Nagai N., Is hida S. and Okada Y.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.2007
- Author(s)
  Kobayashi A., Okazaki S., Enomoto H., Shiomi T., Obata K., Okada Y.
- Journal Title
  
  Arch. Pathol. Lab. Med. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Hypoxia disturbs the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells2007
- Author(s)
  Koto T., Takubo K., Ishida S., Shimoda H., Inoue M., Tsubota K., Okada Y., Ikeda E.
- Journal Title
  
  Am. J. Pathol. (In press)
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Joint diseases and matrix metalloproteinases : A role for MMP-13.2007
- Author(s)
  Takaishi H, Kimura T, Dalal S, Okada Y, D'Armiento J.
- Journal Title
  
  Cur. Pharma. Biotechonol. (In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Joint diseases and matrix metalloproteinases : A role for MMP-132007
- Author(s)
  Takaishi H., Kimura T., Dalal S., Okada Y., D'Armiento J.
- Journal Title
  
  Cur. Pharma. Biotechonol. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.2007
- Author(s)
  Kobayashi A, Okazaki S, Enomoto H, Shiomi T, Obata K, Okada Y.
- Journal Title
  
  Arch. Pathol. Lab. Med. (In press)
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis rheumatoid arthritis.2007
- Author(s)
  Kobayashi A., Okazaki S., Enomoto EL, Shiomi T., Obata K., Okada Y
- Journal Title
  
  Arch. Pathol. Lab. Med. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Modulation of the microenvironment and adhesion of cancer cells byADAMs (a disintegrin and metalloproteinases).2007
- Author(s)
  Okada Y.
- Journal Title
  
  Verh. Dtsch. Ges. Path. 91
  
  Pages: 29-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Bone growth retardation in mouse embryos expressing humancollagenase 1.2007
- Author(s)
  Imai K., Dalai S.S., Hambor J., Mitchell p., Okada Y., Horton W.C. and D'Armiento J.
- Journal Title
  
  Am. J. Physiol. Cell Physiol. 293
  
  Pages: 1209-1215
- NAID
  10012785975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Mochizuki S., Okada Y.
- Journal Title
  
  Cancer Sci. (In press)
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] ADAMs in cancer cell proliferation and progression2007
- Author(s)
  Mochizuki S. and Okada Y
- Journal Title
  
  Cancer Sci
  
  Volume: 98 Pages: 621-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells2007
- Author(s)
  Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S. and Okada Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 282 Pages: 25864-25874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM28 is overexpressed in human breast carcinomas : Implications for carcinoma cell proliferation through degradation of insulin-like growth factor binding protein-32006
- Author(s)
  Mitsui Y., Mochizuki S., Kodama T., Shimoda M., Ohtsuka T., Shiomi T., Chijiiwa M., Ikeda T., Kitajima M., Okada Y.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 9913-9920
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of zymogen of matrix metalloproteinase-7 (matrilysin 1) in osteoarthritic cartilage.2006
- Author(s)
  Fujita Y, Shiomi T, Yanagimoto S, Matsumoto H, Toyama Y, Okada Y
- Journal Title
  
  Arthritis Rheum. 54
  
  Pages: 3233-3243
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of zymogen of matrix metalloproteinase-7 (matrilysin 1) in osteoarthritic cartilage.2006
- Author(s)
  Fujita Y., Shiomi T., Yanagimoto S., Matsumoto H., Toyama Y., Okada Y
- Journal Title
  
  Arthritis Rheum. 54
  
  Pages: 3233-3243
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.2006
- Author(s)
  Imai K, Morikawa M, D'Arminento J, Matsumoto H, Komiya K, Okada Y.:
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
  
  Pages: 1615-1620
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Chondromodulin-I maintain cardiac valvular function by preventing angiogenesis.2006
- Author(s)
  Yoshioka M., Yuasa S., Matsumoto K., Shiomi T., Shukunami C, Okada Y, Mukai M., Shin H., Yozu R., Sata M., Ogawa S., Hiraki Y, Fukuda K.
- Journal Title
  
  Nat. Med. 12
  
  Pages: 1151-1159
- NAID
  10017243402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis.2006
- Author(s)
  Imai K, Morikawa M, D'Arminento J, Matsumoto H, Komiya K, Okada Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
  
  Pages: 1615-1620
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAM28 is overexpressed in human breast carcinomas : Implications for carcinoma cell proliferation through degradation of insulin-like growth factor binding protein-32006
- Author(s)
  Mitsui Y., Mochizuki S., Kodama T., Shimoda M., Ohtsuka T., Shiomi T., Chijiiwa M., Ikeda T., Kitajima M., Okada Y.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 9913-9920
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of zymogen of matrix metalloproteinase-7 (matrilysin 1) in osteoarthritic cartilage.2006
- Author(s)
  Fujita Y, Shiomi T., Yanagimoto S., Matsumoto H., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Rheum. 54
  
  Pages: 3233-3243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis.2006
- Author(s)
  Ohtsuka T., Shiomi T., Shimoda M., Kodama T., Amour A., Murphy G., Ohuchi E., Kobayashi K., Okada Y.
- Journal Title
  
  Int.J.Cancer 118
  
  Pages: 263-273
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis2006
- Author(s)
  Ohtsuka T., Shiomi T., Shimoda M., Kodama T., Amour A., Murphy G., Ohuchi E., Kobayashi K., Okada Y.
- Journal Title
  
  Int. J. Cancer 118
  
  Pages: 263-273
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Chondromodulin-1 maintain cardiac valvular function by preventing angiogenesis2006
- Author(s)
  Yoshioka M., Yuasa S., Matsumura K., Shiomi T., Shukunami C., Okada Y., Mukai M., Shin H., Yozu R., Sata M., Ogawa S., Hiraki Y., Fukuda K.
- Journal Title
  
  Nat. Med. 12
  
  Pages: 1151-1159
- Data Source
  KAKENHI-PROJECT-18060038
[Journal Article] Chondromodulin-I maintain cardiac valvular function by preventing angiogenesis.2006
- Author(s)
  Yoshioka M, Yuasa S, Matsumura K, Shiomi T, Shukunami C, Okada Y, Mukai M, Shin H, Yozu R, Sata M, Ogawa S, Hiraki Y, Fukuda K.
- Journal Title
  
  Nat. Med. 12
  
  Pages: 1151-1159
- NAID
  10017243402
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Expression of Ets-l and its implications for angiogenesis in human renal cell carcinomas2006
- Author(s)
  Mikami S., Oya M., Mizuno R., Murai M., Mukai M., Okada Y.
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 875-882
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis2006
- Author(s)
  Ohtsuka T., Shiomi T., Shimoda M., Kodama T., Amour A., Murphy G., Ohuchi E., Kobayashi K., Okada Y.
- Journal Title
  
  Int. J. Cancer 118
  
  Pages: 263-273
- Data Source
  KAKENHI-PROJECT-18013046
[Journal Article] Human glioblastomas overexpress ADAMTS-5 that degrades brevican.2005
- Author(s)
  Nakada M., Miyamori H., Kita D., Takahashi T., Yamashita J., Sato H., Miura R., Yamaguchi Y., Okada Y.
- Journal Title
  
  Acta Neuropathol. 110
  
  Pages: 239-246
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Expression of ADAM15 in rheumatoid synovium : up-regulation by vascular endothelial growth factor and possible implications for angiogenesis.2005
- Author(s)
  Komiya K., Enomoto H., Inoki I., Okazaki S., Fujita Y., Ikeda E., Ohuchi E., Matsumoto H., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Res.Ther. 7
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151.2005
- Author(s)
  Shiomi T., Inoki I., Kataoka F., Ohtsuka T., Hashimoto G., Nemori R., Okada Y.
- Journal Title
  
  Lab.Invest. 85
  
  Pages: 1489-1506
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Development of in situ zymography to selectively localize active matrix metalloproteinase (matrilsn-1).2005
- Author(s)
  Nemori R., Yamamoto M., Arakatsu H., Kataoka F., Hashimoto G., Shiomi T., Okada Y.
- Journal Title
  
  J.Histochem.Cytochem. 53
  
  Pages: 1227-1234
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice.2005
- Author(s)
  Matsumura S., Iwanaga S., Mochizuki S., Okamoto H., Ogawa S., Okada Y.
- Journal Title
  
  J.Clin.Invest. 115
  
  Pages: 599-609
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.2004
- Author(s)
  Hashimoto G., Shimoda M., Okada Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 32483-32491
- Data Source
  KAKENHI-PROJECT-15659362
[Journal Article] ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of HB-EGF.2004
- Author(s)
  Kodama T., Ikeda E., Okada A., Ohtuska T., Shimoda M., Shiomi T., Yoshida K., Nakada M., Ohuchi E., Okada Y.
- Journal Title
  
  Am J.Pathol. 165
  
  Pages: 1743-1753
- Data Source
  KAKENHI-PROJECT-16209015
[Journal Article] MMP and ADAM in rheumatoid arthritis.2004
- Author(s)
  Yatabe T., Okada Y.
- Journal Title
  
  Connective Tissue 36
  
  Pages: 223-231
- NAID
  110004014526
- Data Source
  KAKENHI-PROJECT-15659362
[Journal Article] Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.
- Author(s)
  Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
- Journal Title
  
  Am J Pathol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590317
[Patent] HUMAN ANTIBODY AGAINST AGGRECANASE-TYPE ADAMTS SPECIES FOR THERAPEUTICS OF AGGRECANASE-RELATED DISEASES2016
- Inventor(s)
  Miyakoshi A., Okada Y., et al.
- Industrial Property Rights Holder
  Miyakoshi A., Okada Y., et al.
- Industrial Property Rights Type
  特許
- Filing Date
  2016
- Acquisition Date
  2018
- Data Source
  KAKENHI-PROJECT-16H05454
[Patent] 抗ヒト膜型ADAM28抗体2015
- Inventor(s)
  宮越陽、古城周久、岡田保典、望月早月、下田将之
- Industrial Property Rights Holder
  宮越陽、古城周久、岡田保典、望月早月、下田将之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-045244
- Filing Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-24249022
[Patent] Human antibody aginast aggrecanase-type ADAMTS species for therapeutics of aggrecanase-related diseases2014
- Inventor(s)
  宮越陽、中村美紀子、古城周久、望月早月、岡田保典
- Industrial Property Rights Holder
  宮越陽、中村美紀子、古城周久、望月早月、岡田保典
- Industrial Property Rights Type
  特許
- Filing Date
  2014-10-14
- Overseas
- Data Source
  KAKENHI-PROJECT-24249022
[Patent] ANTI-ADAM28 ANTIBODIES FOR THERAPEUTICS FOR CARCINOMAS2012
- Inventor(s)
  Yasunoti Okada　他5名
- Industrial Property Rights Holder
  Yasunoti Okada　他5名
- Industrial Property Rights Type
  特許
- Filing Date
  2012-11-19
- Overseas
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Understanding the Challenges in Glioblastoma Treatment2019
- Author(s)
  Susana de Vega, Yasunori Okada
- Organizer
  Ⅱ Encuentro de ACE Japon (II Meeting of Spanish Researchers in Japan
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] IL-6を介した変形性関節症滑膜線維芽細胞によるHYBID（KIAA1199）過剰発現は関節液中ヒアルロン酸分解に関わる2019
- Author(s)
  塩澤淳、Susana de Vega、Mehmet Z. Cilek、良永知穂、中村智美、笠松慎也、吉田浩之、金子晴香、石島旨章、金子和夫、岡田保典
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] 関節軟骨破壊と再生の基礎研究2019
- Author(s)
  岡田保典
- Organizer
  第32回日本軟骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] Fibulin-7 modulates glioblastoma neovascularization via regulation of the Ang1/Ang2-Tie2 system2019
- Author(s)
  Susana de Vega, Mitsutoshi Nakada, and Yasunori Okada
- Organizer
  第78回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] Expression and roles of HYBID (Hyaluronan-binding protein involved in hyaluronan depolymerization), alias CEMIP/KIAA1199, in osteoarthritis2019
- Author(s)
  Yasunori Okada
- Organizer
  The 11th International Conference on Proteoglycans
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] HYBIDは変形性膝関節症滑膜組織で過剰発現し関節液中ヒアルロン酸分解に関与する2019
- Author(s)
  塩澤淳、Susan de Vega、Mehmet Z. Cilek、良永知穂、中村智美、笠松慎也、吉田浩之、金子晴香、石島旨章、金子和夫、岡田保典
- Organizer
  第51回日本結合組織学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] Role of the matricellular protein Fibulin-7 in glioblastoma vascularization2019
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Hajime Arai, Shabierjiang Jiapaer, Hemragul Sabit, Mitsutoshi Nakada, Tomoko Ikeuchi, Muneaki Ishijima, Eri Arikawa-Hirasawa, Yoshihiko Yamada and Yasunori Okada
- Organizer
  The Matricellular Proteins in Tissue Remodeling and Inflammation Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] HYBIDの変形性関節症（OA）関節軟骨での発現亢進とヒアルロン酸（HA）分解における役割2019
- Author(s)
  下田将之、清水英德、望月早月、吉田浩之、塩澤淳、石島旨章、金子和夫、中村雅也、戸山芳昭、岡田保典
- Organizer
  第108回日本病理学総会
- Data Source
  KAKENHI-PROJECT-19H03788
[Presentation] ヒアルロン酸（HA）の作用と各種疾患におけるHA分解酵素HYBID（Hyaluronan binding protein involved in hyaluronan depolymerization）の役割2018
- Author(s)
  岡田保典
- Organizer
  第50回日本結合組織学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] 変形性関節症の病態解析と診断法開発研究　―現状と今後の展望―2018
- Author(s)
  岡田保典
- Organizer
  第58回関東整形災害外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] Overexpression of Fibulin-7 Modulates the Ang1-Tie2 System and Contributes to the Aberrant Vasculature in Glioblastoma2018
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Eri Arikawa-Hirasawa, Yasunori Okada
- Organizer
  Matrix Biology Europe
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] 関節軟骨破壊と再生の基礎研究2018
- Author(s)
  岡田保典
- Organizer
  第32回日本軟骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] HYBIDの変形性関節症関節軟骨での発現とヒアルロン酸分解における役割解析2018
- Author(s)
  清水英徳、下田将之、望月早月、宮前結加、阿部仁、千々岩みゆき、吉田浩之、塩澤淳、石島旨章、金子和夫、金治有彦、中村雅也、戸山芳昭、岡田保典
- Organizer
  第31回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] Fibulin-7 overproduction contributes to glioma vascularization via interaction with angiopoietin-12018
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Eri Arikawa-Hirasawa and Yasunori Okada
- Organizer
  第107回日本病理学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] Analysis of the expression and prospective role of Fibulin-7 in aberrant blood vessel formation in glioblastoma2017
- Author(s)
  Susana de Vega, Akihide Kondo, Mario Suzuki, Eri Arikawa-Hirasawa and Yasunori Okada
- Organizer
  第49回日本結合組織学会学術大会抄録
- Data Source
  KAKENHI-PROJECT-17K08770
[Presentation] MMP-3：RA関節軟骨破壊での役割、診断薬としての有用性および今後の課題。2016
- Author(s)
  岡田保典
- Organizer
  第60回日本リウマチ学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] MMP-3: Its role in cartilage destruction and usefulness for diagnosis of RA.2016
- Author(s)
  Yasunori Okada
- Organizer
  Guangdon Medical Association of Rheumatology Annual Academic Conference 2016.
- Place of Presentation
  広州、中国
- Year and Date
  2016-09-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] 関節軟骨と滑膜の再生能概論。2016
- Author(s)
  岡田保典
- Organizer
  第31回日本臨床リウマチ学会。
- Place of Presentation
  東京
- Year and Date
  2016-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] ヒアルロン酸―アグリカンネットワーク分解を介した軟骨破壊メカニズムと分子標的治療の可能性。2016
- Author(s)
  岡田保典
- Organizer
  第31回日本整形外科基礎学術集会
- Place of Presentation
  博多
- Year and Date
  2016-10-14
- Invited
- Data Source
  KAKENHI-PROJECT-16H05454
[Presentation] ヒトADAM28活性阻害抗体の開発とそれによる癌細胞増殖・転移抑制作用2013
- Author(s)
  望月早月、岡田保典
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] 関節軟骨の破壊と再生機序2013
- Author(s)
  岡田保典
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Selective inhibition of ADAM28 activity by human anti-ADAM28 antibodies suppresses cancer cell proliferation and metastasis2013
- Author(s)
  Satsuki Mochizuki, Hitoshi Abe, Masyuki Shimoda, Noriko Aramaki-Hattori, Yuka Miyamae, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Organizer
  9th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] SrcはADAM28の発現に重要な役割を果たす2013
- Author(s)
  望月早月、阿部仁、尾原健太郎、落合大樹、北川雄光、樋野興夫、佐藤博、岡田保典
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] メタロプロテアーゼADAM28の腫瘍細胞における発現機構と悪性化への関与2013
- Author(s)
  望月早月、阿部仁、尾原健太郎、上野万里、落合大樹、北川雄光、樋野興夫、佐藤博、岡田保典
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] 変形性関節症関節軟骨の破壊と再生におけるメタロプロテアーゼの役割2013
- Author(s)
  岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] ADAM28による癌細胞転移機構とその制御2013
- Author(s)
  望月早月、下田将之、宮越陽、古城周久、岡田保典
- Organizer
  第45回日本結合組織学会学術大会、第60回マトリックス研究会大会合同学術大会
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] MMPs in diagnosis and pathogenesis of cardiovascular disease2013
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metaloproteinases
- Place of Presentation
  Il Ciocco, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Promotion of cancer cell proliferation and metastasis by ADAM28 and possibility of ADAM28 target therapy2013
- Author(s)
  岡田保典
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] 関節リウマチ関節破壊：現状とこれからの研究・治療への展望2013
- Author(s)
  岡田保典
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Selective inhibition of ADAM28 activity by human anti-ADAM28 antibodies suppresses cancer cell proliferation and metastasis.2013
- Author(s)
  Satsuki Mochizuki, Hitoshi Abe, Masyuki Shimoda, Noriko Aramaki-Hattori, Yuka Miyamae, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Organizer
  Pan Pacific Connective Tissue Society Symposium
- Place of Presentation
  Hong Kong.
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Aggrecanase-type ADAMTS species in human osteoarthritic cartilage: Expression and cytokine reactivity in chondrocytes and development of human neutralizing antibodies.2013
- Author(s)
  Aya Shiraishi, Satsuki Mochizuki, Akira Miyakoshi, Kanehisa Kojoh and Yasunori Okada
- Organizer
  Pan Pacific Connective Tissue Society Symposium
- Place of Presentation
  Hong Kong.
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] メタロプロテアーゼADAM28によるvon Willebrand factor分解と癌細胞転移機構2012
- Author(s)
  望月早月、副島見事、下田将之、阿部仁、佐々木文、岡野ジェイムズ洋尚、岡野栄之、岡田保典
- Organizer
  第17回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] ADAM28による癌細胞新規転移促進機構2012
- Author(s)
  望月早月、副島見事、下田将之、岡田保典
- Organizer
  第21回日本がん転移学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] メタロプロテアーゼによる組織内微小環境因子代謝と癌細胞の増殖・浸潤・転移2012
- Author(s)
  岡田保典
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] 病的組織破壊とリモデリングにおけるメタロプロテアーゼ(MMP/ADAM)の作用解析2012
- Author(s)
  岡田保典
- Organizer
  第25回肝類洞壁細胞研究会
- Place of Presentation
  東京・東京ガーデンパレス(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 組織破壊とリモデリングの病理学的研究：統括病理学の時代を迎えて2012
- Author(s)
  岡田保典
- Organizer
  第101回日本病理学会春期総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] メタロプロテアーゼ(MMP/ADAM)を標的としたOA治療:現状と将来2012
- Author(s)
  岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  愛知・ウイルあいち(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] メタロプロテアーゼ（MMP/ADAM）の機能関節疾患での役割2012
- Author(s)
  岡田保典
- Organizer
  第33回日本炎症・再生医学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] Novel effect of ADAM28 on promotion of carcinoma cell metastasis2012
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda, and Yasunori Okada
- Organizer
  XXIIIrd FECTS and ISMB Joint Meeting
- Place of Presentation
  Katowice
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] メタロプロテアーゼ(MMP/ADAM)を標的としたOA治療:現状と将来2012
- Author(s)
  岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  名古屋
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 as a possible molecular target for non-small cell lung carcinoma (NSCLC) and breast carcinoma2012
- Author(s)
  Satsuki Mochizuki, Masayuki Shimoda and Yasunori Okada
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] ADAM28のvon Willebrand factor分解による新規癌細胞転移機構2012
- Author(s)
  望月早月、副島見事、下田将之、阿部仁、佐々木文、岡野ジェイムズ洋尚、岡野英之、岡田保典
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590490
[Presentation] 関節リウマチにおける関節軟骨破壊とメタロプロテアーゼ2011
- Author(s)
  岡田保典
- Organizer
  第55回日本リウマチ学会
- Place of Presentation
  兵庫・神戸ポートピアホテル(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 統括病理学の時代における病理学研究2011
- Author(s)
  岡田保典
- Organizer
  第100回日本病理学会春期総会
- Place of Presentation
  神奈川・パシフィコ横浜(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 promotes cancer cell proliferation and progression through metabolism of tissue microenvironmental factors2011
- Author(s)
  Yasunori Okada
- Organizer
  Korean Society of Matrix Biology
- Place of Presentation
  韓国・テグ(招待講演)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 関節軟骨のリモデリング2011
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第57回日本病理学会秋期総会
- Place of Presentation
  東京・日本教育会館(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinases
- Place of Presentation
  米国,Smithfield, Rhode Island
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 may promote VEGF165-induced angiogenesis in breast carcinomas by the CTGF digestion in the CTGF/VEGF165 complex2011
- Author(s)
  Satsuki Mochizuki, Rena Tanaka, and Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinase
- Year and Date
  2011-08-10
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAM28のCTGF分解を介したCTGF/VEGF_<165>複合体からのVEGF_<165>の遊離と血管新生促進作用2011
- Author(s)
  望月早月、田中伶奈、岡田保典
- Organizer
  第20回がん転移学会学術集会・総会
- Place of Presentation
  浜松
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] RA滑膜組織におけるアグリカナーゼ型ADAMTS分子の発現と治療戦略2011
- Author(s)
  岡田保典
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋・ベイシア文化ホール(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] CTGF/VEGF165複合体形成とMMP/ADAM分子によるCTGF分解2011
- Author(s)
  岡田保典
- Organizer
  第4回日本CCNファミリー研究会
- Place of Presentation
  岡山・アークホテル岡山(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 関節リウマチにおける関節軟骨破壊とメタロプロテアーゼ2011
- Author(s)
  岡田保典
- Organizer
  第55回日本リウマチ学会
- Place of Presentation
  神戸
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 関節疾患における関節軟骨の破壊と再生機構2011
- Author(s)
  岡田保典
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  群馬・ベイシア文化ホール(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] MMP/ADAMと癌の増殖・浸潤・転移2011
- Author(s)
  岡田保典
- Organizer
  第100回日本病理学会春期総会
- Place of Presentation
  神奈川・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 結合組織増殖因子(Connective tissue growth factor, CTGF)は、ADAM28の新規基質である2011
- Author(s)
  望月早月、田中伶奈、岡田保典
- Organizer
  第43回日本結合組織学会学術大会、第58回マトリックス研究会大会合同学術集会
- Place of Presentation
  別府
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAM28による癌細胞転移機構2011
- Author(s)
  望月早月、下田将之、岡田保典
- Organizer
  弟9回日本エラスチン研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] Substrates and roles of ADAM28 in human cancers. Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors2010
- Author(s)
  Yasunori Okada
- Organizer
  Invited speaker
- Place of Presentation
  IlCiocco, Italy
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 癌細胞転移におけるADAM28の役割2010
- Author(s)
  望月早月、下田雅之、岡田保典
- Organizer
  第19回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAM28のヒト癌細胞増殖・転移への関与と肺癌診断への応用2010
- Author(s)
  望月早月、岡田保典
- Organizer
  第42回日本結合組織学会学術大会、第57回マトリックス研究会大会合同学術集会
- Place of Presentation
  秋田
- Year and Date
  2010-08-19
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] Substrates and roles of ADAM28 in human cancers.2010
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors.
- Place of Presentation
  Il Ciocco, Italy
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 組織内微小環境因子代謝酵素(MMPs/ADAMs)と関節軟骨の破壊・再生2010
- Author(s)
  岡田保典
- Organizer
  第54回日本リウマチ学会
- Place of Presentation
  神戸(教育講演)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28 is involved in the invasion and metastasis of cancer cells by escaping from apoptosis through the cleavage of von Willebrand factor2009
- Author(s)
  Satsuki Mochizuki, Masayuki Shimoda, Kenji Soejima, Hirotaka James Okano, Osahiko Tsuji, and Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinase
- Place of Presentation
  Les Diablerets
- Year and Date
  2009-09-02
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAM28はVWF誘導性のアポトーシスを抑制し、癌細胞の浸潤・転移促進に働く2009
- Author(s)
  望月早月、下田雅之、岡野洋尚、岡田保典
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] ADAMs in tumor growth and progression2009
- Author(s)
  Yasunori Okada
- Organizer
  In Gordon Research Conference on MMPs
- Place of Presentation
  Les Diablerets, Switzerland
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAMs in tumor growth and progression.2009
- Author(s)
  Yasunori Okada
- Organizer
  Gordon Research Conference on MMPs.
- Place of Presentation
  Les Diablerets, Switzerland.
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] The role of ADAM28 in cancer cell proliferation and progression2009
- Author(s)
  Satsuki Mochizuki, Masayuki Shimoda, Kenji Soejima, Rena Tanaka, Hirotaka James Okano, Osahiko Tsuji and Yasunori Okada
- Organizer
  8^<th> Pan-Pacific Connective Tissue Society Symposium
- Place of Presentation
  Yokosuka
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21590421
[Presentation] 組織内微小環境因子代謝酵素ADAMの性質とヒト癌組織での役割2009
- Author(s)
  岡田保典
- Organizer
  第20回日本消化器癌発生学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20013040
[Presentation] ADAMs in tumor growth and progression.2009
- Author(s)
  Okada Y.
- Organizer
  In Gordon Research Conference on MMPs
- Place of Presentation
  Invited speaker
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] ADAM28による癌細胞の増殖・浸潤・転移2008
- Author(s)
  望月早月、下田雅之、副島見事、岡田保典
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] ADAM28 may promote cancer cell metastasis by preventing apoptosis through cleavage of von Willebrand factor2008
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda and Yasunori Okada
- Organizer
  The 6^<th> International Symposium on Cancer Research and Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] 低酸素刺激下の脳血管内皮細胞におけるclaudin-5蛋白質の動態2008
- Author(s)
  池田栄二、皆川卓也、厚東隆志、岡田保典
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590366
[Presentation] Analysis of ADAM28-interacting protein that may be related to cancer cell invasion and metastasis : ADAM28 directly binds to and cleaves von Willebrand factor2008
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda and Yasunori Okada
- Organizer
  FECTS XXIst Meeting
- Place of Presentation
  Marseille
- Year and Date
  2008-07-13
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] MMP/ADAMによる組織内微小環境因子代謝2008
- Author(s)
  岡田保典
- Organizer
  第97回日本病理学会
- Place of Presentation
  金沢
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] Hypoxia disrupts the blood-brain barrier through modification of claudin-5 molecules in neural vascular endothelial cells2008
- Author(s)
  Minagawa T, Matsuda S, Koto T, Okada Y, Ikeda E.
- Organizer
  15th International Vascular Biology Meeting
- Place of Presentation
  Sydney, Australia
- Year and Date
  2008-06-02
- Data Source
  KAKENHI-PROJECT-19590366
[Presentation] 癌細胞の浸潤・転移に関わるADAM28の結合蛋白質及び新規基質の探索2008
- Author(s)
  望月早月、副島見事、下田将之、岡田保典
- Organizer
  第40回日本結合組織学会学術大会・第55回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] [Modulation of the microenviromnent and adhesion of cancer cellsbv ADAM (a disinteerin and metalloproteinase)]2007
- Author(s)
  Yasunori Okada
- Organizer
  第91回ドイツ病理学会総会
- Place of Presentation
  Magdeburg, Germany.Thomas Kirchner
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18013046
[Presentation] [Modulation of the microenviromnent and adhesion of cancer cellsbv ADAM fa disintesrin and metalloproteinase)]2007
- Author(s)
  Yasunori Okada
- Organizer
  Gordon conference on Matrix Metalloproteinase
- Place of Presentation
  I1 Ciocco, Italy
- Year and Date
  2007-07-04
- Data Source
  KAKENHI-PROJECT-18013046
[Presentation] High molecular weight hyaluronan inhibits ADAMTS4 (aggrecanase-1) expression through the CD44 signaling pathway in human osteoarthritic chondrocytes2007
- Author(s)
  Taku Yatabe, Satsuki Mochizuki, Masayuki Takizawa, Miyuki Chijiiwa, Aiko Okada, Tokuhiro Kimura, Yoshinari Fujita, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
- Organizer
  7th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  Cairns
- Year and Date
  2007-10-30
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] ADAM28 binds to and cleaves von Willebrand factor2007
- Author(s)
  Satsuki Mochizuki, Kenji Soejima, Masayuki Shimoda and Yasunori Okada
- Organizer
  Gordon Research Conference on Matrix Metalloproteinase
- Place of Presentation
  Italy
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-19590404
[Presentation] OA関節軟骨の破壊と再生
- Author(s)
  岡田保典
- Organizer
  第6回日本関節鏡・膝・スポーツ整形外科学会
- Place of Presentation
  広島市、広島県、広島国際会議場
- Year and Date
  2014-07-25 – 2014-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] OA関節軟骨代謝研究の過去と未来
- Author(s)
  岡田保典
- Organizer
  第28回日本軟骨代謝学会
- Place of Presentation
  文京区、東京都、東京医科歯科大学
- Year and Date
  2015-03-06 – 2015-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.
- Author(s)
  Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama. and Okada Y.
- Organizer
  Matrix Biology Europe 2014.
- Place of Presentation
  Rotterdam, Netherlands
- Year and Date
  2014-06-20 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-24249022
[Presentation] 創傷治癒の病理学―二次性創傷治癒におけるMMPの役割―
- Author(s)
  岡田保典
- Organizer
  第16回日本褥瘡学会
- Place of Presentation
  名古屋市、愛知県、名古屋国際会議場
- Year and Date
  2014-08-29 – 2014-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-24249022

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Okada Yasunori 岡田 保典

OKADA YASUNORI 岡田 保典

OKADA Yasunori 岡田 保典

岡田 保典 オカダ ヤスノリ

Research Projects

Research Products

Co-Researchers

Decipher cell-cell interactionsOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analytical study of infiltrating advanced extracellular matrix microenvironment (niche) of gliomaOngoing

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Pathophysiological study and image analysis of early-stage knee OA by focusing on osteochondrophytesPrincipal InvestigatorOngoing

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Mechanism of articular cartilage destruction in early-stage osteoarthritis and preclinical study on the development of diagnosis and treatment for early-stage osteoarthritis.Principal Investigator

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Pathological study on metalloproteinases in tissue remodeling under pathological conditionsPrincipal Investigator

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ADAM28の癌細胞増殖・浸潤・転移における作用解析Principal Investigator

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Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinasesPrincipal Investigator

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Okada Yasunori 岡田保典

OKADA YASUNORI 岡田保典

OKADA Yasunori 岡田保典

岡田保典オカダヤスノリ