YURUGI Takami 万木貴美

… Alternative Names

小林貴美

Less

Researcher Number	90467473
Affiliation (based on the past Project Information) *help	2011: Kyoto University, 医学(系)研究科(研究院), 研究員 2010 – 2011: 京都大学, 医学研究科, 研究員
Review Section/Research Field	Principal Investigator Endocrinology Except Principal Investigator General medical chemistry
Keywords	Except Principal Investigator 結晶構造解析 / アデノシンA2a受容体 / 立体構造認識抗体 / X線結晶構造解析 / GPCR / モノクローナル抗体

循環関連GPCRの安定化変異体を用いた機能性抗体の創出と構造解析への応用Principal Investigator
- Principal Investigator
  
  万木貴美 (小林貴美)
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyoto University
Development of antibody stabilizing active or inactive state of GPCRs.
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University

All 2012 2011 2010

All Journal Article Presentation Book Patent

[Book] Gタンパク共役受容体(GPCR)の三次元結晶構造解析への試み2011
- Author(s)
  小林拓也
- Total Pages
  10
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22659059
[Book] バイオインダストリーGタンパク質共役受容体(GPCR)の三次元結晶構造解析への試み2011
- Author(s)
  小林拓也
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody2012
- Author(s)
  Hino T., et al
- Journal Title
  
  Nature
  
  Volume: 482 Issue: 7384 Pages: 237-40
- DOI
  10.1038/nature10750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-20221010, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23370049, KAKENHI-PROJECT-23657074
[Journal Article] Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist2012
- Author(s)
  Haga K., et al
- Journal Title
  
  Nature
  
  Volume: 482 Issue: 7386 Pages: 547-551
- DOI
  10.1038/nature10753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23370049
[Journal Article] Evaluation of the Pichiapastoris expression system for theproduction of GPCRs for structuralanalysis2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T. Iwata, S. and Kobayashi, T.
- Journal Title
  
  Microb. Cell Fact
  
  Volume: 10 Pages: 24-24
- URL
  http://www.microbialcellfactories.com/content/10/1/24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Cloning, expressionand purification of the anion exchanger 1homologue from basidiomycetePhanerochaete chrysosporium2011
- Author(s)
  Tokuda, N., Igarashi, K., Shimamura, T., Yurugi-Kobayashi, T., Shiroishi, M., Ito, K., Sugawara, T., Asada, H., Murata, T., Nomura, N., Iwata, S. and Kobayashi, T.
- Journal Title
  
  Protein Expr. Purif
  
  Volume: 79 Pages: 81-87
- URL
  http://www.sciencedirect.com/science/article/pii/S1046592811000866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Cysteine-to-serine shuffling using ayeast expression system improves proteinsecretion : case of a nonglycosylatedmutant of miracullin, a taste-modifyingprotein2011
- Author(s)
  Ito, K., Sugawara, T., Koizumi, A., Nakajima, K., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asada, T., Misaka, T., Iwata, S., Kobayashi, T. and Abe, K.
- Journal Title
  
  Biotech. Lett
  
  Volume: 33 Pages: 103-107
- URL
  http://www.springerlink.com/content/j624126g77180652/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Bulky high-mannose-type N-glycanblocks the taste-modifying activity ofmiraculin2010
- Author(s)
  Ito, K., Sugawara, T., Koizumi, A., Nakajima, K. I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Masuda, K., Ishiguro, M., Misaka, T., Iwata, S., Kobayashi, T. and Abe, K.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1800 Pages: 986-992
- URL
  http://www.sciencedirect.com/science/article/pii/S0304416510001625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Patent] 膜蛋白質の立体構造を認識するモノクローナル抗体のスクリーニング方法2010
- Inventor(s)
  岩田想・小林拓也・野村紀通
- Industrial Property Rights Holder
  科学技術振興機構
- Filing Date
  2010
- Overseas
- Data Source
  KAKENHI-PROJECT-22659059
[Presentation] Towards structure based GPCR pharmacology2012
- Author(s)
  小林拓也
- Organizer
  Gordon Research Conference
- Place of Presentation
  米国
- Data Source
  KAKENHI-PROJECT-22659059

1. KOBAYASHI Takuya (20311730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. NOMURA Norimichi (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. IWATA So (60452330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

YURUGI Takami 万木 貴美

小林 貴美

Research Projects

Research Products

Co-Researchers

循環関連GPCRの安定化変異体を用いた機能性抗体の創出と構造解析への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of antibody stabilizing active or inactive state of GPCRs.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Gタンパク共役受容体(GPCR)の三次元結晶構造解析への試み2011

Author(s)

Total Pages

Publisher

Data Source

[Book] バイオインダストリーGタンパク質共役受容体(GPCR)の三次元結晶構造解析への試み2011

Author(s)

Publisher

Data Source

[Journal Article] G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the Pichiapastoris expression system for theproduction of GPCRs for structuralanalysis2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] Cloning, expressionand purification of the anion exchanger 1homologue from basidiomycetePhanerochaete chrysosporium2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] Cysteine-to-serine shuffling using ayeast expression system improves proteinsecretion : case of a nonglycosylatedmutant of miracullin, a taste-modifyingprotein2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] Bulky high-mannose-type N-glycanblocks the taste-modifying activity ofmiraculin2010

Author(s)

Journal Title

URL

Data Source

[Patent] 膜蛋白質の立体構造を認識するモノクローナル抗体のスクリーニング方法2010

Inventor(s)

Industrial Property Rights Holder

Filing Date

Data Source

[Presentation] Towards structure based GPCR pharmacology2012

Author(s)

Organizer

Place of Presentation

Data Source

YURUGI Takami 万木貴美

小林貴美