YAMAGUCHI OSAMU 山口修

… Alternative Names

Yamaguchi Osamu 山口修

YAMAGUCHI Osamu 山口修

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Researcher Number	90467580
Other IDs
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 教授 2025: 大阪大学, 大学院医学系研究科, 招へい教授 2025: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, センター長
Affiliation (based on the past Project Information) *help	2019 – 2024: 愛媛大学, 医学系研究科, 教授 2022 – 2023: 大阪大学, 大学院医学系研究科, 招へい教授 2018 – 2021: 大阪大学, 医学系研究科, 招へい教授 2017: 愛媛大学, 大学院医学系研究科, 教授 2016 – 2017: 大阪大学, 医学系研究科, 准教授 … More 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 講師 2010 – 2011: Osaka University, 大学院・医学系研究科, 助教 2008 – 2011: Osaka University, 医学系研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 59010:Rehabilitation science-related / Cardiovascular medicine / Circulatory organs internal medicine / General medical chemistry
Keywords	Principal Investigator 心不全 / オートファジー / プロテオーム / トランスクリプトーム / 心筋細胞 / 不均一性 / リソソーム / 分解 / ミトコンドリア / ミトコンドリアダイナミクス / 逆リモデリング / 心肥大 / オートファージー … More Except Principal Investigator … More 心不全 / ミトコンドリア / 左房機能 / 心機能 / 予防医学 / 心筋炎症 / 炎症 / 細胞死 / 左房ストレイン / NT-proBNP / 心エコー / 心血管障害 / 尿毒症物質 / 腎不全 / 細胞骨格 / 心肥大 / インドキシル硫酸 / DNAメチル化 / マイトファジー / DNA分解 / 左室拡張能 / 運動処方 / 左室駆出分画の保たれた心不全 / 心臓リハビリテーション / 運動リハビリテーション / 運動負荷心エコー法 / 簡易運動療法 / 活動量計 / 心肺運動負荷試験 / 運動療法 / 疾患バイオマーカー / 病態進行鍵分子 / 臨床検体(手術・血液・剖検サンプル) / 創薬・化合物ライブラリー / バイオマーカー / 質量分析 / 二次元電気泳動 / 網羅解析 / 石灰化 / 大動脈弁狭窄症 / 介在版 / メカノストレス / 介在板 / 微小管 / AMPK / オートファジー / iPS細胞 / 遺伝子改変マウス / DNase II / シグナル伝達 / 分子心臓病態学 / 心筋細胞死 / 細胞内分解系 Less

心筋細胞のheterogeneityとその特性解明に基づいた心疾患の包括的理解Principal Investigator
- Principal Investigator
  
  山口修
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
Application of left atrial strain for building the risk stratification of HFpEF
- Principal Investigator
  
  井上勝次
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
睡眠覚醒障害が心不全フレイルに及ぼす相互作用の解明
- Principal Investigator
  
  上谷晃由
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Ehime University
Elucidation of mitochondrial degradation mechanisms and their application to drug development for heart failure
- Principal Investigator
  
  Kinya Otsu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Pathophysiology of Cardiovascular Injury Caused by Uremic Toxins Focusing on Cytoskeletal Regulation
- Principal Investigator
  
  Makita Ayu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
The Molecular Mechanism of Heart Failure Caused by Lysosomal DysfunctionPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Osamu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
Simplified exercise rehabilitation in heart failure with preserved left ventricular ejection fraction
- Principal Investigator
  
  Inoue Katsuji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Ehime University
Investigation of molecular mechanisms and predictive blood biomarkers in aortic valve stenosis using human clinical specimens
- Principal Investigator
  
  Aono Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
Investigation for a molecular regulatory mechanism inducing endogenous myocardial inflammation
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Regulatory mechanism of mitochondria dynamics during progression of cardiac reverse remodelingPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Osamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Integrated analyses of mitochondria degradation system as a novel therapeutic target of heart failure
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
A novel AMPK singaling at the intercalated disc in heart
- Principal Investigator
  
  SHINTANI YASUNORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
Clarification of the role of regulatory mechanism of mitochondria DNA in heart and the application to treatment of heart failure
- Principal Investigator
  
  Hikoso Shungo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Role of intracellular degradation systems in genesis of heart failure
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The mechanism of non-apoptotic cardiomyocyte cell death
- Principal Investigator
  
  NISHIDA Kazuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of autophagy in the progression of heart failurePrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Osamu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] A prediction model for estimating NT‐proBNP in a general Japanese population: the Toon Health Study2024
- Author(s)
  Inoue Katsuji、Yamamoto Kazumichi、Higashi Haruhiko、Takata Yasunori、Inaba Shinji、Miyazaki Shigehiro、Higaki Akinori、Saito Makoto、Osawa Haruhiko、Yamaguchi Osamu
- Journal Title
  
  ESC Heart Failure
  
  Volume: online ahead of print Issue: 3 Pages: 1-10
- DOI
  10.1002/ehf2.14691
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07510
[Journal Article] Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload2022
- Author(s)
  Akazawa Yasuhiro、Taneike Manabu、Ueda Hiromichi、Kitazume-Taneike Rika、Murakawa Tomokazu、Sugihara Ryuta、Yorifuji Hiroki、Nishida Hiroki、Mine Kentaro、Hioki Ayana、Omiya Shigemiki、Nakayama Hiroyuki、Yamaguchi Osamu、Yoshimori Tamotsu、Sakata Yasushi、Otsu Kinya
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 41-41
- DOI
  10.1038/s41598-021-03920-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02913, KAKENHI-PROJECT-20K08448, KAKENHI-PROJECT-20K08491, KAKENHI-PROJECT-21K08104, KAKENHI-PROJECT-21K21350
[Journal Article] Echocardiographic Assessment of Atrial Function: From Basic Mechanics to Specific Cardiac Diseases2022
- Author(s)
  Katsuji Inoue , Hiroshi Kawakami , Yusuke Akazawa, Haruhiko Higashi, Takashi Higaki, Osamu Yamaguchi
- Journal Title
  
  J Cardiovasc Dev Dis
  
  Volume: 9 Issue: 3 Pages: 68-68
- DOI
  10.3390/jcdd9030068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11255
[Journal Article] O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice.2022
- Author(s)
  Nakao Y, Aono J, Hamaguchi M, Takahashi K, Sakaue T, Inoue K, Ikeda S, Yamaguchi O
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 85-85
- DOI
  10.1038/s41598-021-04096-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09507, KAKENHI-PROJECT-20K08448
[Journal Article] Pathological Evidence of Native Aortic Valve Injury After Impella Support2021
- Author(s)
  Higashi Haruhiko、Nishimura Takashi、Aono Jun、Sakaue Tomohisa、Kurata Mie、Izutani Hironori、Yamaguchi Osamu
- Journal Title
  
  Circulation: Heart Failure
  
  Volume: 14 Issue: 2
- DOI
  10.1161/circheartfailure.120.007571
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08585, KAKENHI-PROJECT-19H03740, KAKENHI-PROJECT-20K07376
[Journal Article] Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts2020
- Author(s)
  Omiya Shigemiki、Omori Yosuke、Taneike Manabu、Murakawa Tomokazu、Ito Jumpei、Tanada Yohei、Nishida Kazuhiko、Yamaguchi Osamu、Satoh Takashi、Shah Ajay M.、Akira Shizuo、Otsu Kinya
- Journal Title
  
  Circulation
  
  Volume: 141 Issue: 8 Pages: 667-677
- DOI
  10.1161/circulationaha.119.044582
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02807
[Journal Article] Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice2019
- Author(s)
  Hiromichi Ueda, Osamu Yamaguchi, Manabu Taneike, Yasuhiro Akazawa, Haruko Wada-Kobayashi, Ryuta Sugihara, Hiroki Yorifuji, Hiroyuki Nakayama, Shigemiki Omiya, MD, Tomokazu Murakawa, Yasushi Sakata, Kinya Otsu
- Journal Title
  
  J Am Coll Cardiol Basic Trans Science
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02807
[Journal Article] Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.2019
- Author(s)
  Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M,?Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H.
- Journal Title
  
  Ann Thorac Surg
  
  Volume: S0003-4975 Issue: 1 Pages: 31717-5
- DOI
  10.1016/j.athoracsur.2019.09.085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04954, KAKENHI-PUBLICLY-19H05418, KAKENHI-PROJECT-17H04656, KAKENHI-PROJECT-17K10231, KAKENHI-PROJECT-19K08585, KAKENHI-PROJECT-20K07376, KAKENHI-PROJECT-20K21632, KAKENHI-PROJECT-19H03740, KAKENHI-PROJECT-20H03719, KAKENHI-PROJECT-20H03890
[Journal Article] FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice.2018
- Author(s)
  Misaka T, Murakawa T, Nishida K, Omori Y, Taneike M, Omiya S, Molenaar C, Uno Y, Yamaguchi O, Takeda J, Shah AM, Otsu K.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 114 Pages: 93-104
- DOI
  10.1016/j.yjmcc.2017.11.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-15K09140
[Journal Article] Alternatively activated macrophages determine repair of the infarcted adult murine heart.2016
- Author(s)
  Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K, Suzuki K.
- Journal Title
  
  J Clin Invest.
  
  Volume: 126 Issue: 6 Pages: 2151-66
- DOI
  10.1172/jci85782
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08271
[Journal Article] mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.2016
- Author(s)
  Taneike M, Nishida K, Omiya S, Zarrinpashneh E, Misaka T, Kitazume-Taneike R, Austin R, Takaoka M, Yamaguchi O, Gambello MJ, Shah AM, Otsu K.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0152628-e0152628
- DOI
  10.1371/journal.pone.0152628
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-15K09140
[Journal Article] Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation.2016
- Author(s)
  Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, Shah AM, Nishida K, Otsu K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 311 Issue: 6 Pages: H1485-H1497
- DOI
  10.1152/ajpheart.00481.2016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04822
[Journal Article] Receptor-mediated mitophagy.2016
- Author(s)
  Yamaguchi O, Murakawa T, Nishida K, Otsu K
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 95 Pages: 50-56
- DOI
  10.1016/j.yjmcc.2016.03.010
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09140
[Journal Article] BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32.2015
- Author(s)
  Otsu K, Murakawa T, Yamaguchi O.
- Journal Title
  
  Autophagy
  
  Volume: 11 Issue: 10 Pages: 1932-3
- DOI
  10.1080/15548627.2015.1084459
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09140, KAKENHI-PROJECT-15H04822
[Journal Article] Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.2015
- Author(s)
  Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 7527-7527
- DOI
  10.1038/ncomms8527
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09140, KAKENHI-PROJECT-26461129, KAKENHI-PUBLICLY-15H01536, KAKENHI-PUBLICLY-26111513, KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-25650067, KAKENHI-PROJECT-25291045, KAKENHI-PROJECT-25713031
[Journal Article] Degradation systems in heart failure.2015
- Author(s)
  Nishida K, Yamaguchi O, Otsu K.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 84 Pages: 212-22
- DOI
  10.1016/j.yjmcc.2015.05.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09140
[Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure2012
- Author(s)
  岡崇史、彦惣俊吾、山口修、種池学、武田理宏、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、審良静男、山本章次、小室一成、大津欣也
- Journal Title
  
  Nature
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Calpain protects the heart from hemodynamic stress2011
- Author(s)
  種池学、山口修, ほか
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 37 Pages: 32170-32177
- DOI
  10.1074/jbc.m111.248088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Calpain protects the heart from hemodynamic stress2011
- Author(s)
  Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 32170-32177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Calpain protects the heart from hemodynamic stress2011
- Author(s)
  種池学、溝手勇、森田孝、渡部徹也、彦惣俊吾、山口修、武田理宏、岡崇史、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、竹田潤二、望月直樹、小室一成、大津欣也
- Journal Title
  
  The Journal of Biological Chemistory
  
  Volume: 286 Pages: 32170-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010
- Author(s)
  Manabu Taneike, Osamu Yamaguchi, 他
- Journal Title
  
  Autophagy
  
  Volume: 6 Pages: 600-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590865
[Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010
- Author(s)
  Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Shirasawa T, Mizushima N, Otsu K.
- Journal Title
  
  Autophagy
  
  Volume: 6 Pages: 600-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Inhibition of autophagy in the heart induces age-relacardiomyopathy.2010
- Author(s)
  種池学, 山口修, 他15名
- Journal Title
  
  Autophag
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590865
[Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010
- Author(s)
  種池学、山口修、中井敦子、彦惣俊吾、武田理宏、溝手勇、岡崇史、玉井敬人、大藪丈太、村川智一、西田和彦、清水孝彦、堀正二、小室一成、白澤卓司、水島昇、大津欣也
- Journal Title
  
  Autophagy
  
  Volume: 6 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Activation of MTK1/MEKK4 inducescardiomocyte death and heart failure.2010
- Author(s)
  溝手勇, 山口修, 他11名
- Journal Title
  
  Mol Cell Cardiol. 48巻
  
  Pages: 302-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590865
[Journal Article] Activation of MTK1/ MEKK4 induces cardiomyocyte death and heart failure2010
- Author(s)
  Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 48 Pages: 283-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Novel in vivo tool to evaluate autophagic activity in the heart2010
- Author(s)
  Osamu Yamaguchi, 他
- Journal Title
  
  Circulation Journal 74
  
  Pages: 49-50
- NAID
  10025941131
- Data Source
  KAKENHI-PROJECT-20590865
[Journal Article] I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pahway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.2009
- Author(s)
  彦惣俊吾, 山口修, 他15名
- Journal Title
  
  Circ Res. 105巻
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590865
[Journal Article] Downregulation of chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes.2009
- Author(s)
  大宮茂幹, 彦惣俊吾, 山口修(5番目), 他12名
- Journal Title
  
  J Mol Cell Cardiol 46巻
  
  Pages: 59-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590865
[Journal Article] The IkappaB kinase beta/ nuclear factor kappaB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression2009
- Author(s)
  Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K.
- Journal Title
  
  Circ Res
  
  Volume: 105 Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Reductin in hemoglobin-oxygen affinity results in the improvement of exercise with chronic heart failure.2008
- Author(s)
  渡部徹也, 武田理宏, 大宮茂幹, 彦惣俊吾, 山口修, 他14名
- Journal Title
  
  J Am Coll Cardiol. 52巻
  
  Pages: 779-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] 心筋におけるミトコンドリア分解と心不全発症の関わり2022
- Author(s)
  山口修
- Organizer
  日本心不全学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08448
[Presentation] The Role of Autophagy in the Pathogenesis of Cardiac Diseases2018
- Author(s)
  山口修
- Organizer
  第82回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09140
[Presentation] The Role of Autophagic Degradation in Heart Failure2018
- Author(s)
  山口修
- Organizer
  第82回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09140
[Presentation] mitochondria dynamics　～mitophagy と心機能～2018
- Author(s)
  山口修
- Organizer
  第82回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09140
[Presentation] Involvement of mitochondrial DNA accumulation with inflammatory response during progression of heart failure2017
- Author(s)
  山口修
- Organizer
  第34回国際心臓研究学会（ISHR）日本部会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09140
[Presentation] オートファジーとは？心疾患における意義2017
- Author(s)
  山口修
- Organizer
  第123回日本循環器学会近畿地方会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09140
[Presentation] Autophagy and quality controlo of mitochondria during progression of heart failure2017
- Author(s)
  山口修
- Organizer
  日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09140
[Presentation] The Degradation System in Cardiomyopathy2011
- Author(s)
  山口修
- Organizer
  第75回日本循環器学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2011-03-18
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] Mitochondrial Permeability Transition and Non-apoptotic Cell Death2010
- Author(s)
  Osamu Yamaguchi
- Organizer
  Basic Cardiovascular Sciences 2010 Scientific Sessions
- Place of Presentation
  Rancho Mirage, CA (USA)(招待講演)
- Year and Date
  2010-07-20
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] 血行動態負荷並びに老化における心筋細胞オートファジーの役割2010
- Author(s)
  山口修
- Organizer
  第14回日本心不全学会
- Place of Presentation
  東京
- Year and Date
  2010-10-10
- Data Source
  KAKENHI-PROJECT-21390240
[Presentation] Mitochondrial Permeability Transition and Non-qpoptotic Cell Death.2010
- Author(s)
  山口修
- Organizer
  Basic Cardiovascular Sciences 2010 Scientific Sessions.
- Place of Presentation
  Rancho Mirage(米国)
- Year and Date
  2010-07-20
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] Essential Role of Autophagy to Maintain Cardiac Function in Response to Hemodynamic Stress and in Senescence.2009
- Author(s)
  山口修
- Organizer
  第26回国際心臓研究会日本部会
- Place of Presentation
  札幌
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] Essential Role of Autophagy to Maintain Cardiac Function in Response to Hemodynamic Stress and in Senescence2009
- Author(s)
  山口修
- Organizer
  第26回国際心臓研究会日本部会
- Place of Presentation
  札幌・北海道大学
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] Non-apoptotic Cardiomyocyte Death as a Cause of Cardiac Remodeling.2009
- Author(s)
  山口修
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] Cell death and cardiac remodeling2008
- Author(s)
  山口修
- Organizer
  第25回國際心臓研究会日本部会
- Place of Presentation
  横浜
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20590865
[Presentation] Cell death and cardiac remodeling2008
- Author(s)
  山口修
- Organizer
  第2 5回国際心臓研究会日本部会
- Place of Presentation
  横浜
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20590865

1. OTSU Kinya (20294051)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. HIKOSO Shungo (30423164)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. Aono Jun (70512169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Inoue Katsuji (50512167)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 種池学 (30609756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 坂上倫久 (20709266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 東晴彦 (10598634)

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# of Collaborated Products: 2 results
8. MURAKAWA Tomokazu

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. NISHIDA Kazuhiko (90362681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. SHINTANI YASUNORI (20712243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. MORISHIMA Keisuke (60359114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YALIKUN Yaxiaer (30735064)

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# of Collaborated Products: 0 results
13. TSUKAMOTO Osamu (80589151)

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14. KATO Hisakazu (30589312)

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15. Makita Ayu (70837038)

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16. 濱口美香 (80815928)

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17. 上谷晃由 (00423450)

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18. 岡靖哲 (60419025)

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19. 木下将城 (60838564)

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20. 莖田昌敬 (00709602)

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21. 白井学 (70294121)

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22. 若林真樹 (70552024)

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23. 高田康徳 (20432792)

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24. YASUI Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. UEDA Hiromichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. AKAZAWA Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. YASHIROGI Shohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YAZAWA Issei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. NANBA Daisuke

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# of Collaborated Products: 1 results
30. 池田俊太郎

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# of Collaborated Products: 1 results

YAMAGUCHI OSAMU 山口 修

Yamaguchi Osamu 山口 修

YAMAGUCHI Osamu 山口 修

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心筋細胞のheterogeneityとその特性解明に基づいた心疾患の包括的理解Principal Investigator

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The Molecular Mechanism of Heart Failure Caused by Lysosomal DysfunctionPrincipal Investigator

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Regulatory mechanism of mitochondria dynamics during progression of cardiac reverse remodelingPrincipal Investigator

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YAMAGUCHI OSAMU 山口修

Yamaguchi Osamu 山口修

YAMAGUCHI Osamu 山口修