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Tsukamoto Osamu  塚本 蔵

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TSUKAMOTO Osamu  塚本 蔵

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Researcher Number 80589151
Other IDs
Affiliation (Current) 2020: 大阪大学, 生命機能研究科, 准教授
Affiliation (based on the past Project Information) *help 2020: 大阪大学, 生命機能研究科, 准教授
2016 – 2019: 大阪大学, 医学系研究科, 助教
2017: 大阪大学, 大学院医学系研究科, 助教
2015: 大阪大学, 大学院医学系研究科, 助教
2013 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 … More
2014: 大阪大学, 医学系研究科
2014: 大阪大学, 大学院医学系研究科, 特任研究員
2012: 大阪大学, 医学(系)研究科(研究院), 研究員
2011: 大阪大学, 医学系・研究科, 特任研究員
2010 – 2011: 大阪大学, 医学系研究科, 特任研究員 Less
Review Section/Research Field
Principal Investigator
Cardiovascular medicine / Circulatory organs internal medicine
Except Principal Investigator
Cardiovascular medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / General medical chemistry / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 55060:Emergency medicine-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords
Principal Investigator
c-myc / 転写複合体 / 心筋細胞特異的遺伝子発現制御 / クロスリンク反応 / AMPK / PDLIM5 / cell migration / AMPK / cell migration / AMPキナーゼ … More / Pdlim5 / 細胞遊走 / ミオシン調節軽鎖キナーゼ / 心不全 / サルコメア / cMLCK / キナーゼ活性化機構 / cardiac MLCK … More
Except Principal Investigator
心不全 / 循環器・高血圧 / エピゲノム / 細胞核クロマチン / 難治性心不全 / 分子循環器病学 / 臨床循環器 / 創薬 / AMPK / 微小管 / メカノストレス / 組織・細胞 / 生体分子 / 細胞・組織 / 小胞体ストレス / 腹部大動脈瘤 / 低酸素 / ジスルフィド結合 / 慢性心不全 / 自然免疫 / 心筋保護 / 内因性免疫 / G蛋白共役受容体 / 心筋リモデリング / 心筋細胞 / G蛋白共役性受容体 / IL-33 / ST2受容体 / MAPキナーゼ / NF-kB / 心筋肥大 / アポトーシス / 利尿ホルモン / モデル動物 / ナトリウム利尿ホルモン / エンハンサー / シグナル伝達 / BNP / 転写因子 / メカニカルストレス / 発現制御 / 介在板 / 介在版 / ミオシン調節軽鎖キナーゼ / 肥大型心筋症 / 心筋症 / ゲノム / オミックス / アセチルコリン受容体拮抗薬アトロ / 麻酔覚醒 / 洞性徐脈 / 瞳孔拡張 / 迷走神経緊張 / 心臓介在板 / 遺伝性心血管疾患 / 登録観察研究 / 心血管イベントリスク / 次世代シークエンサー / 疾患特異的iPS細胞 Less
  • Research Projects

    (16 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (46 People)
  •  分子疫学的コホート研究による遺伝性心血管疾患のリスク層別化・病態解明・治療薬探索Ongoing

    • Principal Investigator
      藤野 陽
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Kanazawa University
  •  遺伝性心筋症ゲノム解析および横断オミックス解析による新規分子標的の同定と創薬開発Ongoing

    • Principal Investigator
      朝野 仁裕
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Osaka University
  •  麻酔科領域で使用されるアトロピンの効果を改善するアトロピンエステラーゼ製剤の開発Ongoing

    • Principal Investigator
      山崎 悟
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fractionOngoing

    • Principal Investigator
      北風 政史
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      National Cardiovascular Center Research Institute
  •  メカノシグナルによる心筋微小管の動的制御機構の解明と治療への応用Ongoing

    • Principal Investigator
      新谷 泰範
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Osaka University
  •  心臓特異的ミオシン軽鎖キナーゼの活性制御機構の解明と治療への応用Principal InvestigatorOngoing

    • Principal Investigator
      塚本 蔵
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model

    • Principal Investigator
      ASANO Yoshihiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development

    • Principal Investigator
      TAKASHIMA Seiji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  A novel AMPK singaling at the intercalated disc in heart

    • Principal Investigator
      SHINTANI YASUNORI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  anti-atherosclerotic and anti-cancer effects of AMPK activationPrincipal Investigator

    • Principal Investigator
      Tsukamoto Osamu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Development of simple and noninvasive method to assess the severity of heart failure

    • Principal Investigator
      TAKASHIMA Seiji
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor

    • Principal Investigator
      Sanada Shoji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Role of ER oxidoreductin-1 in cardiovascular remodeling

    • Principal Investigator
      MINAMINO TETSUO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  A New Diagnostics Method for Refractory Heart Failure

    • Principal Investigator
      ASANO YOSHIHIRO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Identification of cardiomyocyte-specific transcriptional mechanism of c-mycPrincipal Investigator

    • Principal Investigator
      TSUKAMOTO Osamu
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease

    • Principal Investigator
      TAKASHIMA Seiji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University

All 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book Patent

  • [Book] 心不全の基礎研究 心不全の分子機序 Ca2+ハンドリング サルコメアタンパク質異常 日本臨床 心不全(第2版)上 最新の基礎・臨床研究の進歩76巻2019

    • Author(s)
      塚本蔵
    • Total Pages
      7
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Book] 直接的サルコメア制御剤による新しい心不全治療薬の開発 実験医学37巻 心不全のサイエンス2019

    • Author(s)
      塚本蔵
    • Total Pages
      5
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Journal Article] Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.2019

    • Author(s)
      Yamada Noriaki、Asano Yoshihiro、Fujita Masashi、Yamazaki Satoru、Inanobe Atsushi、Matsuura Norio、Kobayashi Hatasu、Ohno Seiko、Ebana Yusuke 他
    • Journal Title

      Circulation

      Volume: 139 Pages: 2157-2169

    • DOI

      10.1161/circulationaha.118.036761

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07251, KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302
  • [Journal Article] Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy.2019

    • Author(s)
      Hodatsu A, Fujino N, Uyama Y, Tsukamoto O, Imai-Okazaki A, Yamazaki S, Seguchi O, Konno T, Hayashi K, Kawashiri MA, Asano Y, Kitakaze M, Takashima S, Yamagishi M
    • Journal Title

      ESC Heart Failure

      Volume: 6 Pages: 06-415

    • DOI

      10.1002/ehf2.12410

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-18H04050, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04826
  • [Journal Article] Radiation-induced HFpEF model as a potential tool for the exploration of novel therapeutic targets.2017

    • Author(s)
      Tsukamoto O, Kitakaze M
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 313

    • DOI

      10.1152/ajpheart.00307.2017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Journal Article] Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy2016

    • Author(s)
      Ito S, Asakura M, Liao Y, Min KD, Takahashi A, Shindo K, Yamazaki S, Tsukamoto O, Asanuma H, Mogi M, Horiuchi M, Asano Y, Sanada S, Minamino T, Takashima S, Mochizuki N, Kitakaze M.
    • Journal Title

      J. Am. Heart. Assoc

      Volume: 5

    • DOI

      10.1161/jaha.116.003521

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K09111
  • [Journal Article] A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure2016

    • Author(s)
      Kanzaki M, Asano Y, Ishibashi-Ueda H, Oiki E, Nishida T, Asanuma H, Kato H, Oka T, Ohtani T, Tsukamoto O, Higo S, Kioka H, Matsuoka K, Sawa Y, Komuro I, Kitakaze M, Takashima S, Sakata Y.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0148209

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K09139
  • [Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA2016

    • Author(s)
      Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
    • Journal Title

      Science Report

      Volume: 6 Pages: 28592-28592

    • DOI

      10.1038/srep28592

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
  • [Journal Article] Higd1a is a positive regulator of Cytochrome c Oxidase2015

    • Author(s)
      T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
    • Journal Title

      Proc Natl Acad Sci U SA

      Volume: 112 Pages: 1553-1553

    • DOI

      10.1073/pnas.1419767112

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
  • [Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015

    • Author(s)
      Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S..
    • Journal Title

      Nat Commun.

      Volume: 30 Pages: 6137-6150

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670402
  • [Journal Article] Recent Progress and Next Challenges in the Treatment of Symptomatic Heart Failure in Japan2015

    • Author(s)
      Tsukamoto O, Kitakaze M
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 11 Pages: 2322-2323

    • DOI

      10.1253/circj.cj-15-1014

      10.1253/circj.CJ-15-1014

    • NAID

      130005104913

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461108
  • [Journal Article] Different Implications of Functional Tricuspid Regurgitation Between Heart Failure (HF) With Reduced Ejection Fraction (EF) and HF With Preserved EF2015

    • Author(s)
      Tsukamoto O, Kitakaze M
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 7 Pages: 1448-1449

    • DOI

      10.1253/circj.cj-15-0560

      10.1253/circj.CJ-15-0560

    • NAID

      130005083967

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461108
  • [Journal Article] Targeting lysosomal Ca2+ to reduce reperfusion injury.2015

    • Author(s)
      Tsukamoto O, Asanuma H, Kitakaze M.
    • Journal Title

      Cardiovasc Res

      Volume: 108 Pages: 321-323

    • DOI

      10.1093/cvr/cvv242

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461108
  • [Journal Article] Augmented AMPK activity 1 inhibits cell migration by phosphorylating the novel substrate Pdlim52015

    • Author(s)
      Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
    • Journal Title

      Nature Communications

      Volume: 6 Pages: 0-0

    • DOI

      10.1038/ncomms7137

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-25461119
  • [Journal Article] Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing hear2014

    • Author(s)
      Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S.
    • Journal Title

      FASEB J

      Volume: 28(4) Pages: 1870-1870

    • DOI

      10.1096/fj.13-245522

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24790757, KAKENHI-PUBLICLY-25118709, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26860559
  • [Journal Article] PDE5 inhibitor efficacy is estrogen dependent in female heart disease.2014

    • Author(s)
      32.Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.
    • Journal Title

      J Clin Invest.

      Volume: 124 Pages: 2464-2464

    • DOI

      10.1172/jci70731

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461108
  • [Journal Article] Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2014

    • Author(s)
      Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 111 Pages: 273-273

    • DOI

      10.1073/pnas.1318547111

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23227006, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24570149, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PROJECT-24790917, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25461119, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26461108
  • [Journal Article] It is Time to Reconsider the Cardiovascular Protection Afforded by RAAS Blockade-Overview of RAAS Systems2012

    • Author(s)
      Tsukamoto O and Kitakaze M.
    • Journal Title

      Cardiovasc Drugs Ther

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] It is Time to Reconsider the Cardiovascular Protection Afforded by RAAS Blockade-Overview of RAAS Systems2011

    • Author(s)
      Osamu Tsukamoto
    • Journal Title

      Cardiovascular Drugs and Therapy

    • DOI

      10.1007/s10557-011-6361-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).2010

    • Author(s)
      Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
    • Journal Title

      The Journal of biological chemistry. 285(41)

      Pages: 31337-31347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390225
  • [Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/ CRE-like element in cardiomyocytes2010

    • Author(s)
      Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 48 Pages: 1280-1289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Ablation of C/EBP homologous protein attenuates ER-mediated apoptosis and cardiac dysfunction induced by pressure overload.2010

    • Author(s)
      Fu HY, Tsukamoto O
    • Journal Title

      Circulation

      Volume: 122 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1.2010

    • Author(s)
      Higo S, Tsukamoto O
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Functional alterations of cardiac proteasomes under physiological and pathological conditions2010

    • Author(s)
      Tsukamoto O, Minamino T, Kitakaze M.
    • Journal Title

      Cardiovasc Res

      Volume: 85 Pages: 339-346

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1(HP1)2010

    • Author(s)
      Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 31337-31347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010

    • Author(s)
      Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I.
    • Journal Title

      Journal of molecular and cellular cardiology. 48(6)

      Pages: 1280-1289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390225
  • [Journal Article] Ablation of C/ EBP Homologous Protein Attenuates Endoplasmic Reticulum-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload2010

    • Author(s)
      Fu HY, Okada K, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T.
    • Journal Title

      Circulation

      Volume: 122 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] What is the role of ER stress in the heart? Introduction and series overview2010

    • Author(s)
      Kitakaze M and Tsukamoto O.
    • Journal Title

      Circ Res

      Volume: 208 Pages: 15-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy.2010

    • Author(s)
      Drews O, Tsukamoto O
    • Journal Title

      Circulation Research

      Volume: 107 Pages: 1094-1101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy2010

    • Author(s)
      Drews O, Tsukamoto O, Liem D, Streicher J, Wang Y, Ping P.
    • Journal Title

      Circ Res

      Volume: 107 Pages: 1094-1101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload.2010

    • Author(s)
      Fu HY, Okada K, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T.
    • Journal Title

      Circulation. 122(4)

      Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390225
  • [Journal Article] What is the role of ER stress? Introduciton and series overview.2010

    • Author(s)
      Kitakaze M, Tsukamoto O
    • Journal Title

      Circulation Research

      Volume: 107 Pages: 15-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890103
  • [Journal Article] PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts.2009

    • Author(s)
      Asai M, Tsukamoto O, Minamino T, Asanuma H, Fujita M, Asano Y, Takahama H, Sasaki H, Higo S, Asakura M, Takashima S, Hori M, Kitakaze M.
    • Journal Title

      Journal of molecular and cellular cardiology. 46(4)

      Pages: 452-462

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390225
  • [Patent] 心不全の重症度を無侵襲で経時的に正確に定量評価可能なマウス2013

    • Inventor(s)
      高島成二, 朝野仁裕, 松岡研, 塚本蔵, 北風政史
    • Industrial Property Rights Holder
      高島成二, 朝野仁裕, 松岡研, 塚本蔵, 北風政史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-228824
    • Filing Date
      2013-09-02
    • Data Source
      KAKENHI-PROJECT-24591097
  • [Presentation] Direct sarcomere activators for the advanced stage systolic heart failure2019

    • Author(s)
      Osamu Tsukamoto
    • Organizer
      第83回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Presentation] Myosin Regulatory Light Chain Phosphorylation as a Modulator of Sarcomere Contractility2019

    • Author(s)
      Osamu Tsukamoto
    • Organizer
      第83回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Presentation] 心筋症の病態とこれに基づく薬物治療の期待2017

    • Author(s)
      塚本蔵
    • Organizer
      第3回日本心筋症研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Presentation] 第21回日本心不全学会2017

    • Author(s)
      塚本蔵
    • Organizer
      Translation of the Research from Bench to Bedside to Create the Drugs for Heart Failure
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Presentation] Therapeutic Application of Direct Sarcomere Modulators for Heart Failure2017

    • Author(s)
      塚本蔵
    • Organizer
      第21回日本心不全学会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Presentation] 心不全治療を目的としたミオシン軽鎖リン酸化を調節する低分子化合物の開発2017

    • Author(s)
      塚本蔵
    • Organizer
      KEK 構造生物学研究センターセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09578
  • [Presentation] Development of direct sarcomere modulators for the treatment of heart failure2017

    • Author(s)
      塚本蔵
    • Organizer
      心血管代謝週間(CVMW)2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09578
  • 1.  ASANO Yoshihiro (60527670)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 14 results
  • 2.  HIGO Schuichiro (00604034)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 3.  TAKASHIMA Seiji (90379272)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 4.  MINAMINO Tetsuo (30379234)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 5.  KATO Hisakazu (30589312)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 6.  SHINTANI Yasunori (20712243)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 7.  YAMAZAKI Satoru (70348796)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 8.  SANADA Shoji (70593797)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  北風 政史 (20294069)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 10.  HAO Hiroyuki (40393243)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OGITA Hisakazu (50379236)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  MORISHIMA Keisuke (60359114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YALIKUN Yaxiaer (30735064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YAMAGUCHI Osamu (90467580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  西田 優也 (10793440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  木岡 秀隆 (70642099)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 17.  宮下 洋平 (60816312)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  中谷 明弘 (60301149)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  藤野 陽 (40361993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  林 研至 (00422642)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 21.  多田 隼人 (90623653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  中西 千明 (80623660)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  野村 章洋 (30707542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  高村 雅之 (60362000)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NAKANO Atsushi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 26.  Yan Yi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 27.  YASHIROGI Shohei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  YAZAWA Issei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  ASAKURA Masanori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 30.  IHARA Madoka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  MIN Kyung-Duk
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 32.  ITO Shin
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 33.  EBANA Yusuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  IMAMURA Hiromi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  SEGUCHI Osamu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  小倉 尚志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  浅沼 博司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 38.  吉川 信也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  新沢 伊藤恭子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  小室 一成
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 41.  油谷 浩幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  大野 聖子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  野地 博行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  鈴木 俊治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  藤川 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  坂田 泰史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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