Tsukamoto Osamu 塚本蔵

… Alternative Names

Researcher Number	80589151
Affiliation (Current)	2020: 大阪大学, 生命機能研究科, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 大阪大学, 生命機能研究科, 准教授 2016 – 2019: 大阪大学, 医学系研究科, 助教 2017: 大阪大学, 大学院医学系研究科, 助教 2015: 大阪大学, 大学院医学系研究科, 助教 2013 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 … More
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / General medical chemistry / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 55060:Emergency medicine-related
Keywords	Principal Investigator c-myc / 転写複合体 / 心筋細胞特異的遺伝子発現制御 / クロスリンク反応 / AMPK / PDLIM5 / cell migration / ＡＭＰＫ / ｃｅｌｌ　ｍｉｇｒａｔｉｏｎ / AMPキナーゼ … More Except Principal Investigator 心不全 / 循環器・高血圧 / エピゲノム / 細胞核クロマチン / 難治性心不全 / 分子循環器病学 / 臨床循環器 / 創薬 / AMPK / 微小管 / メカノストレス / 組織・細胞 / 生体分子 / 細胞・組織 / 小胞体ストレス / 腹部大動脈瘤 / 低酸素 / ジスルフィド結合 / 慢性心不全 / 自然免疫 / 心筋保護 / 内因性免疫 / G蛋白共役受容体 / 心筋リモデリング / 心筋細胞 / G蛋白共役性受容体 / IL-33 / ST2受容体 / MAPキナーゼ / NF-kB / 心筋肥大 / アポトーシス / 利尿ホルモン / モデル動物 / ナトリウム利尿ホルモン / エンハンサー / シグナル伝達 / BNP / 転写因子 / メカニカルストレス / 発現制御 / 介在板 / 介在版 / 心筋症 / ゲノム / オミックス / 心臓介在板 / ミオシン調節軽鎖キナーゼ / 肥大型心筋症 / 遺伝性心血管疾患 / 登録観察研究 / 心血管イベントリスク / 次世代シークエンサー / 疾患特異的iPS細胞 / アセチルコリン受容体拮抗薬アトロピン / 迷走神経緊張 / 麻酔覚醒 / 洞性徐脈 / 瞳孔拡張 / 自然淘汰 / アセチルコリン受容体拮抗薬アトロ Less

分子疫学的コホート研究による遺伝性心血管疾患のリスク層別化・病態解明・治療薬探索Ongoing
- Principal Investigator
  
  藤野陽
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kanazawa University
遺伝性心筋症ゲノム解析および横断オミックス解析による新規分子標的の同定と創薬開発Ongoing
- Principal Investigator
  
  朝野仁裕
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
麻酔科領域で使用されるアトロピンの効果を改善するアトロピンエステラーゼ製剤の開発Ongoing
- Principal Investigator
  
  山崎悟
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Cardiovascular Center Research Institute
メカノシグナルによる心筋微小管の動的制御機構の解明と治療への応用Ongoing
- Principal Investigator
  
  新谷泰範
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
  Osaka University
Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fractionOngoing
- Principal Investigator
  
  北風政史
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinasePrincipal Investigator
- Principal Investigator
  
  Tsukamoto Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model
- Principal Investigator
  
  ASANO Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
A novel AMPK singaling at the intercalated disc in heart
- Principal Investigator
  
  SHINTANI YASUNORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
anti-atherosclerotic and anti-cancer effects of AMPK activationPrincipal Investigator
- Principal Investigator
  
  Tsukamoto Osamu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Development of simple and noninvasive method to assess the severity of heart failure
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor
- Principal Investigator
  
  Sanada Shoji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Role of ER oxidoreductin-1 in cardiovascular remodeling
- Principal Investigator
  
  MINAMINO TETSUO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
A New Diagnostics Method for Refractory Heart Failure
- Principal Investigator
  
  ASANO YOSHIHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Identification of cardiomyocyte-specific transcriptional mechanism of c-mycPrincipal Investigator
- Principal Investigator
  
  TSUKAMOTO Osamu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2020 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book Patent

[Book] 心不全の基礎研究　心不全の分子機序　Ca2+ハンドリング　サルコメアタンパク質異常　日本臨床　心不全(第2版)上　最新の基礎・臨床研究の進歩76巻2019
- Author(s)
  塚本蔵
- Total Pages
  7
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-17K09578
[Book] 直接的サルコメア制御剤による新しい心不全治療薬の開発　実験医学37巻　心不全のサイエンス2019
- Author(s)
  塚本蔵
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17K09578
[Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2020
- Author(s)
  Nagao Takemasa、Shintani Yasunori、Hayashi Takaharu、Kioka Hidetaka、Kato Hisakazu、Nishida Yuya、Yamazaki Satoru、Tsukamoto Osamu、Yashirogi Shohei、Yazawa Issei、Asano Yoshihiro、Shinzawa‐Itoh Kyoko、Imamura Hiromi、Suzuki Takeo、Suzuki Tsutomu、Goto Yu‐ichi、Takashima Seiji
- Journal Title
  
  FASEB J
  
  Volume: 34 Pages: 1859-1871
- DOI
  10.1096/fj.201800389r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K22246, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-18H02094, KAKENHI-PROJECT-17K09577
[Journal Article] In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance2020
- Author(s)
  Kioka Hidetaka、Kato Hisakazu、Fujita Takeshi、Asano Yoshihiro、Shintani Yasunori、Yamazaki Satoru、Tsukamoto Osamu、Imamura Hiromi、Kogo Mikihiko、Kitakaze Masafumi、Sakata Yasushi、Takashima Seiji
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Pages: 2041-2054
- DOI
  10.1096/fj.201901686r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17K09577
[Journal Article] 心臓病における創薬開発、新たな治療介入で疾患を克服する2019
- Author(s)
  山田憲明, 塚本蔵
- Journal Title
  
  心臓
  
  Volume: 51 Pages: 1252-1259
- Data Source
  KAKENHI-PROJECT-18H04050
[Journal Article] 直接的サルコメア制御剤による新しい心不全治療薬の開発2019
- Author(s)
  塚本蔵
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 143-149
- Data Source
  KAKENHI-PROJECT-18H04050
[Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation2019
- Author(s)
  Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Zankov DP, Shimizu A, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S
- Journal Title
  
  Circulation.
  
  Volume: in press Pages: 2157-2169
- DOI
  10.1161/circulationaha.118.036761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-17K07251, KAKENHI-PROJECT-18K08033, KAKENHI-PROJECT-19K08538, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17H04018, KAKENHI-PROJECT-18H02808
[Journal Article] Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies.2019
- Author(s)
  Tsukamoto O.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21
- DOI
  10.3390/ijms21010226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04050
[Journal Article] Impact of Cardiac Myosin Light Chain Kinase Gene Mutation on Development of Dilated Cardiomyopathy2019
- Author(s)
  Hodatsu A, Fujino N, Uyama Y, Tsukamoto O, Imai-Okazaki A, Yamazaki S, Seguchi O, Konno T, Hayashi K, Kawashiri MA, Asano Y, Kitakaze M, Takashima S, Yamagishi M
- Journal Title
  
  ESC Heart Fail.
  
  Volume: 6 Pages: 06-415
- DOI
  10.1002/ehf2.12410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-18H04050, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04826, KAKENHI-PROJECT-19K08553, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18K15863, KAKENHI-PROJECT-17K09082
[Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.2019
- Author(s)
  Kamikubo Kenta、Kato Hisakazu、Kioka Hidetaka、Yamazaki Satoru、Tsukamoto Osamu、Nishida Yuya、Asano Yoshihiro、Imamura Hiromi、Kawahara Hiroyuki、Shintani Yasunori、Takashima Seiji
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294 Pages: 14562-14573
- DOI
  10.1074/jbc.ra119.008544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K09408, KAKENHI-PUBLICLY-19H05293, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17H03657, KAKENHI-PROJECT-17K09577
[Journal Article] Radiation-induced HFpEF model as a potential tool for the exploration of novel therapeutic targets.2017
- Author(s)
  Tsukamoto O, Kitakaze M
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 313
- DOI
  10.1152/ajpheart.00307.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09578
[Journal Article] A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure2016
- Author(s)
  Kanzaki M, Asano Y, Ishibashi-Ueda H, Oiki E, Nishida T, Asanuma H, Kato H, Oka T, Ohtani T, Tsukamoto O, Higo S, Kioka H, Matsuoka K, Sawa Y, Komuro I, Kitakaze M, Takashima S, Sakata Y.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0148209
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K09139
[Journal Article] Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy2016
- Author(s)
  Ito S, Asakura M, Liao Y, Min KD, Takahashi A, Shindo K, Yamazaki S, Tsukamoto O, Asanuma H, Mogi M, Horiuchi M, Asano Y, Sanada S, Minamino T, Takashima S, Mochizuki N, Kitakaze M.
- Journal Title
  
  J. Am. Heart. Assoc
  
  Volume: 5
- DOI
  10.1161/jaha.116.003521
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K09111
[Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA2016
- Author(s)
  Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
- Journal Title
  
  Science Report
  
  Volume: 6 Pages: 28592-28592
- DOI
  10.1038/srep28592
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
[Journal Article] Different Implications of Functional Tricuspid Regurgitation Between Heart Failure (HF) With Reduced Ejection Fraction (EF) and HF With Preserved EF2015
- Author(s)
  Tsukamoto O, Kitakaze M
- Journal Title
  
  Circulation Journal
  
  Volume: 79 Issue: 7 Pages: 1448-1449
- DOI
  10.1253/circj.cj-15-0560
  10.1253/circj.CJ-15-0560
- NAID
  130005083967
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461108
[Journal Article] Augmented AMPK activity 1 inhibits cell migration by phosphorylating the novel substrate Pdlim52015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
- Journal Title
  
  Ｎature Ｃommunications
  
  Volume: 6 Pages: 0-0
- DOI
  10.1038/ncomms7137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-25461119
[Journal Article] Higd1a is a positive regulator of Cytochrome c Oxidase2015
- Author(s)
  T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
- Journal Title
  
  Proc Natl Acad Sci U SA
  
  Volume: 112 Pages: 1553-1553
- DOI
  10.1073/pnas.1419767112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
[Journal Article] Targeting lysosomal Ca2+ to reduce reperfusion injury.2015
- Author(s)
  Tsukamoto O, Asanuma H, Kitakaze M.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 108 Pages: 321-323
- DOI
  10.1093/cvr/cvv242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461108
[Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S..
- Journal Title
  
  Nat Commun.
  
  Volume: 30 Pages: 6137-6150
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670402
[Journal Article] Recent Progress and Next Challenges in the Treatment of Symptomatic Heart Failure in Japan2015
- Author(s)
  Tsukamoto O, Kitakaze M
- Journal Title
  
  Circulation Journal
  
  Volume: 79 Issue: 11 Pages: 2322-2323
- DOI
  10.1253/circj.cj-15-1014
  10.1253/circj.CJ-15-1014
- NAID
  130005104913
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461108
[Journal Article] Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing hear2014
- Author(s)
  Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S.
- Journal Title
  
  FASEB J
  
  Volume: 28(4) Pages: 1870-1870
- DOI
  10.1096/fj.13-245522
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24790757, KAKENHI-PUBLICLY-25118709, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26860559
[Journal Article] PDE5 inhibitor efficacy is estrogen dependent in female heart disease.2014
- Author(s)
  32.Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.
- Journal Title
  
  J Clin Invest.
  
  Volume: 124 Pages: 2464-2464
- DOI
  10.1172/jci70731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461108
[Journal Article] Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2014
- Author(s)
  Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 111 Pages: 273-273
- DOI
  10.1073/pnas.1318547111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23227006, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24570149, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PROJECT-24790917, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25461119, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26461108
[Journal Article] It is Time to Reconsider the Cardiovascular Protection Afforded by RAAS Blockade-Overview of RAAS Systems2012
- Author(s)
  Tsukamoto O and Kitakaze M.
- Journal Title
  
  Cardiovasc Drugs Ther
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] It is Time to Reconsider the Cardiovascular Protection Afforded by RAAS Blockade-Overview of RAAS Systems2011
- Author(s)
  Osamu Tsukamoto
- Journal Title
  
  Cardiovascular Drugs and Therapy
- DOI
  10.1007/s10557-011-6361-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] What is the role of ER stress in the heart? Introduction and series overview2010
- Author(s)
  Kitakaze M and Tsukamoto O.
- Journal Title
  
  Circ Res
  
  Volume: 208 Pages: 15-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] Ablation of C/ EBP Homologous Protein Attenuates Endoplasmic Reticulum-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload2010
- Author(s)
  Fu HY, Okada K, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T.
- Journal Title
  
  Circulation
  
  Volume: 122 Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] Ablation of C/EBP homologous protein attenuates ER-mediated apoptosis and cardiac dysfunction induced by pressure overload.2010
- Author(s)
  Fu HY, Tsukamoto O
- Journal Title
  
  Circulation
  
  Volume: 122 Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).2010
- Author(s)
  Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
- Journal Title
  
  The Journal of biological chemistry. 285(41)
  
  Pages: 31337-31347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy2010
- Author(s)
  Drews O, Tsukamoto O, Liem D, Streicher J, Wang Y, Ping P.
- Journal Title
  
  Circ Res
  
  Volume: 107 Pages: 1094-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1(HP1)2010
- Author(s)
  Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 31337-31347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010
- Author(s)
  Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I.
- Journal Title
  
  Journal of molecular and cellular cardiology. 48(6)
  
  Pages: 1280-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1.2010
- Author(s)
  Higo S, Tsukamoto O
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 285 Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload.2010
- Author(s)
  Fu HY, Okada K, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T.
- Journal Title
  
  Circulation. 122(4)
  
  Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy.2010
- Author(s)
  Drews O, Tsukamoto O
- Journal Title
  
  Circulation Research
  
  Volume: 107 Pages: 1094-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] What is the role of ER stress? Introduciton and series overview.2010
- Author(s)
  Kitakaze M, Tsukamoto O
- Journal Title
  
  Circulation Research
  
  Volume: 107 Pages: 15-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] Functional alterations of cardiac proteasomes under physiological and pathological conditions2010
- Author(s)
  Tsukamoto O, Minamino T, Kitakaze M.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 85 Pages: 339-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/ CRE-like element in cardiomyocytes2010
- Author(s)
  Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 48 Pages: 1280-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890103
[Journal Article] PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts.2009
- Author(s)
  Asai M, Tsukamoto O, Minamino T, Asanuma H, Fujita M, Asano Y, Takahama H, Sasaki H, Higo S, Asakura M, Takashima S, Hori M, Kitakaze M.
- Journal Title
  
  Journal of molecular and cellular cardiology. 46(4)
  
  Pages: 452-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Patent] 心不全の重症度を無侵襲で経時的に正確に定量評価可能なマウス2013
- Inventor(s)
  高島成二, 朝野仁裕, 松岡研, 塚本蔵, 北風政史
- Industrial Property Rights Holder
  高島成二, 朝野仁裕, 松岡研, 塚本蔵, 北風政史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-228824
- Filing Date
  2013-09-02
- Data Source
  KAKENHI-PROJECT-24591097
[Presentation] Direct sarcomere activators for the advanced stage systolic heart failure2019
- Author(s)
  Osamu Tsukamoto
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09578
[Presentation] Myosin Regulatory Light Chain Phosphorylation as a Modulator of Sarcomere Contractility2019
- Author(s)
  Osamu Tsukamoto
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09578
[Presentation] Therapeutic Application of Direct Sarcomere Modulators for Heart Failure2017
- Author(s)
  塚本蔵
- Organizer
  第21回日本心不全学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09578
[Presentation] 心不全治療を目的としたミオシン軽鎖リン酸化を調節する低分子化合物の開発2017
- Author(s)
  塚本蔵
- Organizer
  KEK　構造生物学研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K09578
[Presentation] Development of direct sarcomere modulators for the treatment of heart failure2017
- Author(s)
  塚本蔵
- Organizer
  心血管代謝週間(CVMW)2017
- Invited
- Data Source
  KAKENHI-PROJECT-17K09578
[Presentation] 第21回日本心不全学会2017
- Author(s)
  塚本蔵
- Organizer
  Translation of the Research from Bench to Bedside to Create the Drugs for Heart Failure
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09578
[Presentation] 心筋症の病態とこれに基づく薬物治療の期待2017
- Author(s)
  塚本蔵
- Organizer
  第3回日本心筋症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09578

1. ASANO Yoshihiro (60527670)

# of Collaborated Projects: 11 results

# of Collaborated Products: 14 results
2. HIGO Schuichiro (00604034)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
3. TAKASHIMA Seiji (90379272)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. MINAMINO Tetsuo (30379234)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
5. KATO Hisakazu (30589312)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
6. SHINTANI Yasunori (20712243)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
7. YAMAZAKI Satoru (70348796)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
8. SANADA Shoji (70593797)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 北風政史 (20294069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
10. HAO Hiroyuki (40393243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OGITA Hisakazu (50379236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. MORISHIMA Keisuke (60359114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YALIKUN Yaxiaer (30735064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAGUCHI Osamu (90467580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 西田優也 (10793440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 木岡秀隆 (70642099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. 宮下洋平 (60816312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 藤野陽 (40361993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 林研至 (00422642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 多田隼人 (90623653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 中西千明 (80623660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 野村章洋 (30707542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高村雅之 (60362000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 中谷明弘 (60301149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAKANO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
26. Yan Yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
27. YASHIROGI Shohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YAZAWA Issei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. IMAMURA Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
30. SUZUKI Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. EBANA Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. MAKIYAMA Takeru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. ASAKURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
34. MIN Kyung-Duk

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
35. ITO Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. IHARA Madoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. SEGUCHI Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. YAMAGISHI Masakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 浅沼博司

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
40. 鈴木勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
42. 大野聖子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. ZANKOV Dimitar P

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 橋本真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
46. 堀江稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 倉智嘉久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 稲野辺厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 小倉尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 吉川信也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 川尻剛照

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 今井敦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 川原裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 坂田泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 野地博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 鈴木俊治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 藤川誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsukamoto Osamu 塚本 蔵

TSUKAMOTO Osamu 塚本 蔵

Research Projects

Research Products

Co-Researchers

分子疫学的コホート研究による遺伝性心血管疾患のリスク層別化・病態解明・治療薬探索Ongoing

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遺伝性心筋症ゲノム解析および横断オミックス解析による新規分子標的の同定と創薬開発Ongoing

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麻酔科領域で使用されるアトロピンの効果を改善するアトロピンエステラーゼ製剤の開発Ongoing

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メカノシグナルによる心筋微小管の動的制御機構の解明と治療への応用Ongoing

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Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fractionOngoing

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Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinasePrincipal Investigator

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anti-atherosclerotic and anti-cancer effects of AMPK activationPrincipal Investigator

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Tsukamoto Osamu 塚本蔵

TSUKAMOTO Osamu 塚本蔵

[Book] 心不全の基礎研究　心不全の分子機序　Ca2+ハンドリング　サルコメアタンパク質異常　日本臨床　心不全(第2版)上　最新の基礎・臨床研究の進歩76巻2019

[Book] 直接的サルコメア制御剤による新しい心不全治療薬の開発　実験医学37巻　心不全のサイエンス2019