Higo Shuichiro 肥後修一朗

… Alternative Names

Researcher Number	00604034
Affiliation (Current)	2020: 大阪大学, 医学系研究科, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2018 – 2020: 大阪大学, 医学系研究科, 寄附講座准教授 2016 – 2017: 大阪大学, 医学系研究科, 助教 2014 – 2016: 大阪大学, 大学院医学系研究科, 助教 2013 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2014: 大阪大学, 医学系研究科 2013: 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 2012: 大阪大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 心不全 / 高速シークエンサー / ゲノム編集 / エピゲノム / 次世代シークエンサー / 心臓リモデリング / トランスオミクス / 線維芽細胞 / 心筋症 / 拡張型心筋症 … More Except Principal Investigator 心不全 / 心筋症 / ゲノム編集 / 疾患iPS細胞 / 小胞体ストレス / 腹部大動脈瘤 / 低酸素 / ジスルフィド結合 / エピゲノム / 細胞核クロマチン / 難治性心不全 / 分子循環器病学 / 臨床循環器 / 慢性心不全 / 自然免疫 / 心筋保護 / 内因性免疫 / G蛋白共役受容体 / 心筋リモデリング / 心筋細胞 / G蛋白共役性受容体 / IL-33 / ST2受容体 / MAPキナーゼ / NF-kB / 心筋肥大 / アポトーシス / 利尿ホルモン / モデル動物 / 循環器・高血圧 / AMPK / PDLIM5 / cell migration / ＡＭＰＫ / ｃｅｌｌ　ｍｉｇｒａｔｉｏｎ / AMPキナーゼ / Pdlim5 / 細胞遊走 / 細胞間接着 / 循環器内科学 / 難治性心筋症 / 不整脈源性右室心筋症 Less

Development of Human Disease Model of Arrhythmogenic Right Ventricular Cardiomyopathy for Personalized MedicineOngoing
- Principal Investigator
  
  坂田泰史
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Therapeutic development targeting molecular basis of dilated-phase hypertrophic cardiomyopathyPrincipal InvestigatorOngoing
- Principal Investigator
  
  肥後修一朗
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Clarification of molecular pathophysiology and identification of therapeutic target in desmosome-related cardiomyopathyOngoing
- Principal Investigator
  
  彦惣俊吾
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Development of upstream therapy targeting molecular basis of refractory cardiomyopathy
- Principal Investigator
  
  Sakata Yasushi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Therapeutic Application of Genome Editing for Advanced Heart FailurePrincipal Investigator
- Principal Investigator
  
  Shuichiro Higo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Development of simple and noninvasive method to assess the severity of heart failure
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Molecular discovery research targeting cardiac remodeling using multi-directional transcriptional profiling and therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Higo Shuichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
anti-atherosclerotic and anti-cancer effects of AMPK activation
- Principal Investigator
  
  Tsukamoto Osamu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor
- Principal Investigator
  
  Sanada Shoji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Role of ER oxidoreductin-1 in cardiovascular remodeling
- Principal Investigator
  
  MINAMINO TETSUO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
A New Diagnostics Method for Refractory Heart Failure
- Principal Investigator
  
  ASANO YOSHIHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Quantitative Epigenome Mapping to Identify Therapeutic Target in Heart FailurePrincipal Investigator
- Principal Investigator
  
  HIGO Shuichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 心不全のサイエンス　ゲノム編集の難治性心筋症医療応用2019
- Author(s)
  肥後修一朗
- Total Pages
  216
- Publisher
  羊土社
- ISBN
  9784758103770
- Data Source
  KAKENHI-PROJECT-16K09500
[Book] 心不全のサイエンス　ゲノム編集の難治性心筋症医療応用2019
- Author(s)
  肥後修一朗
- Total Pages
  216
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18K19543
[Book] 医療応用をめざすゲノム編集　拡張型心筋症におけるゲノム編集治療2018
- Author(s)
  肥後修一朗
- Total Pages
  274
- Publisher
  化学同人
- ISBN
  9784759817294
- Data Source
  KAKENHI-PROJECT-16K09500
[Book] 心不全　ゲノム編集2018
- Author(s)
  肥後修一朗, 石津宜丸, 坂田泰史
- Total Pages
  720
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-16K09500
[Book] 心不全　ゲノム編集2018
- Author(s)
  肥後修一朗, 石津宜丸, 坂田泰史
- Total Pages
  720
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-18K19543
[Journal Article] Old-Age Onset Progressive Cardiac Contractile Dysfunction in a Patient with Polycystic Kidney Disease Harboring a <i>PKD1</i> Frameshift Mutation2019
- Author(s)
  Suwa Yoshinobu、Higo Shuichiro、Nakamoto Kei、Sera Fusako、Kunimatsu Suzuka、Masumura Yuki、Kanzaki Machiko、Mizote Isamu、Mizuno Hiroya、Fujio Yasushi、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  International Heart Journal
  
  Volume: 60 Issue: 1 Pages: 220-225
- DOI
  10.1536/ihj.18-184
- NAID
  130007557187
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19543, KAKENHI-PROJECT-18K19545, KAKENHI-PROJECT-18K15848, KAKENHI-PROJECT-18H02603, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-17K16004
[Journal Article] Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes2017
- Author(s)
  Ishizu T, Higo S, Masumura Y, Kohama Y, Shiba M, Higo T, Shibamoto M, Nakagawa A, Morimoto S, Takashima S, Hikoso S, Sakata Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 9363-9363
- DOI
  10.1038/s41598-017-09716-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-17K16004, KAKENHI-PROJECT-15H04820
[Journal Article] A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure2016
- Author(s)
  Kanzaki M, Asano Y, Ishibashi-Ueda H, Oiki E, Nishida T, Asanuma H, Kato H, Oka T, Ohtani T, Tsukamoto O, Higo S, Kioka H, Matsuoka K, Sawa Y, Komuro I, Kitakaze M, Takashima S, Sakata Y.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0148209
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K09139
[Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA2016
- Author(s)
  Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
- Journal Title
  
  Science Report
  
  Volume: 6 Pages: 28592-28592
- DOI
  10.1038/srep28592
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
[Journal Article] Augmented AMPK activity 1 inhibits cell migration by phosphorylating the novel substrate Pdlim52015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
- Journal Title
  
  Ｎature Ｃommunications
  
  Volume: 6 Pages: 0-0
- DOI
  10.1038/ncomms7137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-25461119
[Journal Article] Higd1a is a positive regulator of Cytochrome c Oxidase2015
- Author(s)
  T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
- Journal Title
  
  Proc Natl Acad Sci U SA
  
  Volume: 112 Pages: 1553-1553
- DOI
  10.1073/pnas.1419767112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
[Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S..
- Journal Title
  
  Nat Commun.
  
  Volume: 30 Pages: 6137-6150
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670402
[Journal Article] Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2014
- Author(s)
  Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y, Takashima S.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 111(1) Pages: 7-7
- Data Source
  KAKENHI-PROJECT-24790757
[Journal Article] Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA22014
- Author(s)
  Shintani Y, Drexler HC, Kioka H, Terracciano CM, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, Takashima S, Yashiro K, Suzuki K
- Journal Title
  
  EMBO Rep
  
  Pages: 7-7
- Data Source
  KAKENHI-PROJECT-24790757
[Journal Article] Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA22014
- Author(s)
  Shintani Y, Drexler HC, Kioka H, Terracciano CM, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, Takashima S, Yashiro K, Suzuki K.
- Journal Title
  
  EMBO Rep.
  
  Volume: 15 Pages: 199-206
- DOI
  10.1002/embr.201337945
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390212, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PUBLICLY-25111703, KAKENHI-PROJECT-25461346, KAKENHI-PROJECT-25670387, KAKENHI-PUBLICLY-26115504, KAKENHI-PROJECT-26291027, KAKENHI-PROJECT-26560456, KAKENHI-PROJECT-26860559
[Journal Article] Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart2014
- Author(s)
  Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S
- Journal Title
  
  FASEB J
  
  Volume: 28(4) Pages: 1870-9
- Data Source
  KAKENHI-PROJECT-24790757
[Journal Article] Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing hear2014
- Author(s)
  Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S.
- Journal Title
  
  FASEB J
  
  Volume: 28(4) Pages: 1870-1870
- DOI
  10.1096/fj.13-245522
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24790757, KAKENHI-PUBLICLY-25118709, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26860559
[Journal Article] Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2014
- Author(s)
  Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 111 Pages: 273-273
- DOI
  10.1073/pnas.1318547111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23227006, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24570149, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PROJECT-24790917, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25461119, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26461108
[Journal Article] Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer2012
- Author(s)
  K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino
- Journal Title
  
  J Control Release
  
  Volume: 160 Pages: 274-280
- DOI
  10.1016/j.jconrel.2011.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-22890104, KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23659416, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047
[Presentation] Genome Editing Targeting Cardiovascular Disease2019
- Author(s)
  肥後　修一朗
- Organizer
  第83回日本循環器学会学術集会　モーニングレクチャー
- Invited
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Genome Editing Targeting Cardiovascular Disease2019
- Author(s)
  肥後　修一朗
- Organizer
  第83回日本循環器学会学術集会　モーニングレクチャー
- Invited
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Medical Application of Genome Editing for Advanced Heart Failure2019
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  第83回日本循環器学会学術集会　プレナリーセッション
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Medical Application of Genome Editing for Advanced Heart Failure2019
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  第83回日本循環器学会学術集会　プレナリーセッション
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Genome Editing in Cardiomyopathy2018
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  European Society of Cardiology Congress 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Genome Editing in Cardiomyopathy2018
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  European Society of Cardiology Congress 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Verification of novel molecular mechanism of cardiac hypertrophy via regulation of mRNA degradation2018
- Author(s)
  Yuki Masumura, Shuichiro Higo, Shungo Hikoso, Seiji Takashima, Yasushi Sakata
- Organizer
  第2回BCVR
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Rapid Evaluation of Candidate Causal Gene Mutation using High-content Image Analysis Combined with Targeted Gene Disruption2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Masato Shibamoto, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Verification of novel molecular mechanism of cardiac hypertrophy via regulation of mRNA degradation2018
- Author(s)
  Yuki Masumura, Shuichiro Higo, Shungo Hikoso, Seiji Takashima, Yasushi Sakata
- Organizer
  第2回BCVR
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Development of Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Cardiomyocytes2018
- Author(s)
  Takamaru Ishizu, Shuichiro Higo, Shungo Hikoso, Yasushi Sakata
- Organizer
  第1回日本循環器学会基礎研究フォーラム　基礎研究助成講演
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Multiplexed Measurement of Cell-type Specific Calcium Dynamics Using High-content Image Analysis2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Takamaru Ishizu, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Tomoaki Higo, Masato Shibamoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ハイコンテントイメージ解析及びゲノム編集を用いた心筋症遺伝子変異の病原性の迅速な評価系の構築2018
- Author(s)
  増村雄喜、國松鈴花、肥後修一朗、小濱康明、志波幹夫、近藤匠巳、肥後友彰、柴本将人、高島成二、宮川繁、彦惣俊吾、坂田泰史
- Organizer
  第3回心筋症研究会 YIA
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Therapeutic Genome Editing Targeting an Upstream Genetic Basis of Advanced Heart Failure2018
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo, Shungo Hikoso, Yasushi Sakata
- Organizer
  第82回日本循環器学会学術集会　プレナリーセッション
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Dilated Cardiomyopathy2018
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo Hikoso Shungo, Sakata Yasushi
- Organizer
  第9回武田科学振興財団薬科学シンポジウム医薬応用を目指したゲノム編集
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 二度の心停止から蘇生されプラコフィリン2(PKP2)ハプロ不全が同定された不整脈源性右室心筋症(ARVC)の一例2018
- Author(s)
  中村聡希, 肥後修一朗, 南口仁, 世良英子, 水野裕八國松鈴花, 志波幹夫, 高島成二, 彦惣俊吾, 坂田泰史
- Organizer
  第221回日本内科学会近畿地方会
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Rapid Evaluation of Candidate Causal Gene Mutation using High-content Image Analysis Combined with Targeted Gene Disruption2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Masato Shibamoto, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2018（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] 二度の心停止から蘇生されプラコフィリン2(PKP2)ハプロ不全が同定された不整脈源性右室心筋症(ARVC)の一例2018
- Author(s)
  中村聡希, 肥後修一朗, 南口仁, 世良英子, 水野裕八國松鈴花, 志波幹夫, 高島成二, 彦惣俊吾, 坂田泰史
- Organizer
  第221回日本内科学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ゲノム編集の重症心不全医療応用2018
- Author(s)
  肥後修一朗、増村雄喜、彦惣俊吾、坂田泰史
- Organizer
  第22回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ゲノム編集の重症心不全医療応用2018
- Author(s)
  肥後修一朗、増村雄喜、彦惣俊吾、坂田泰史
- Organizer
  第22回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] 高齢期において進行性難治性心不全を呈しPKD1フレームシフト変異が同定された多発性嚢胞腎の1例2018
- Author(s)
  宮崎友希, 肥後修一朗, 諏訪恵信, 中本敬, 世良英子, 溝手勇, 水野裕八, 藤尾慈, 彦惣俊吾, 坂田泰史
- Organizer
  医学生研修医の日本内科学会ことはじめ2018京都
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Clinical application of genome editing for advanced heart failure2018
- Author(s)
  肥後修一朗、増村雄喜、彦惣俊吾、坂田泰史
- Organizer
  第22回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] 拡張型心筋症遺伝子変異に対する相同組換え修復（HDR）を介したゲノム編集治療の開発2017
- Author(s)
  石津宜丸肥後修一朗　増村雄喜　小濱康明　志波幹夫　肥後友彰　柴本将人　中川彰人　森本幸生　高島成二　彦惣俊吾　坂田泰史
- Organizer
  第2回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Development of Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Cardiomyocytes2017
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo,Sachio Morimoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 心筋症遺伝子変異に対する相同組換え修復（HDR）を介したゲノム編集治療の開発2017
- Author(s)
  石津宜丸肥後修一朗　志波幹夫　小濱康明　柴本将人　肥後友彰　中川彰人　増村雄喜　森本幸生　彦惣俊吾　坂田泰史
- Organizer
  第3回心筋症研究会 YIA
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Clarification of the novel mechanism of cardiomyocyte hypertrophy via regulation of RNA metabolism2016
- Author(s)
  増村雄喜, 肥後修一朗, 朝野仁裕, 彦惣俊吾, 坂田泰史, 高島成二
- Organizer
  第33 回ISHR2016
- Place of Presentation
  東京
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Single Cell Imaging Analysis Clarifies RNA Quantity Control Mechanism in Cardiomyocytes2016
- Author(s)
  Yuki Masumura, Shuichiro Higo、Yoshihiro Asano、Hisakazu Kato、Yi Yan、Osamu Tsukamoto、Hidetaka Kioka、Takaharu Hayashi、Yasunori Shintani、Satoru Yamazaki、Tetsuo Minamino、Masafumi Kitakaze、Issei Komuro、Seiji Takashima、Yasushi Sakata.
- Organizer
  第80回日本循環器学会学術集会　Young Investigator's Award Finalists Lectures (Basic Research)
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26860558
[Presentation] Single Cell Imaging Analysis Clarifies Quantitative Kinetics of RNA in Cardiomyocytes2016
- Author(s)
  増村雄喜, 肥後修一朗, 朝野仁裕, 北風政史, 坂田泰史, 高島成二
- Organizer
  第89 回日本生化学学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Molecular Discovery Research using TransOmics in Cardiovascular Pathophysiology.2015
- Author(s)
  Shuichiro Higo, Yuki Masumura, Yoshihiro Asano, Issei Komuro, Masafumi Kitakaze, Yasushi Sakata and Seiji Takashima.
- Organizer
  第79回日本循環器学会学術集会　シンポジウム
- Place of Presentation
  大阪府大阪市
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26860558
[Presentation] 定量的エピゲノム解析を用いた心臓線維芽細胞における細胞周期制御因子の同定2014
- Author(s)
  肥後修一朗、朝野仁裕、増村雄喜、坂田泰史、澤芳樹、北風政史、小室一成、高島成二
- Organizer
  第51回日本臨床分子医学会
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] 定量的エピゲノム解析を用いた心臓線維芽細胞における細胞周期制御因子の同定2014
- Author(s)
  肥後　修一朗、朝野　仁裕、増村　雄喜、坂田　泰史、澤　　芳樹、北風　政史、小室　一成、高島　成二
- Organizer
  第51回日本臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2014-04-11
- Data Source
  KAKENHI-PROJECT-26860558
[Presentation] 定量的エピゲノム解析を用いた心臓線維芽細胞における細胞周期制御因子の同定2014
- Author(s)
  肥後　修一朗
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Comprehensive quantitative epigenome mapping reveals the differential induction of histone H3 lysine 4 trimethylation marks in pressure-overloaded murine hearts2013
- Author(s)
  肥後　修一朗
- Organizer
  AHA scientific sessions 2012
- Place of Presentation
  Losangels, USA
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Comprehensive quantitative epigenome mapping reveals the differential induction of histone H3 lysine 4 trimethylation.2012
- Author(s)
  Shuichiro Higo, Yoshihiro Asano, Seiji Takashima, Masafumi Kitakaze, Issei Komuro
- Organizer
  AHA scientific sessions
- Place of Presentation
  Losangels, USA
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Quantitative ChIP-sequence Analysis Reveals the Differentially Altered Active Epigenomic States in Murine Pressure-overloaded Failing Hearts2012
- Author(s)
  肥後　修一朗
- Organizer
  第29回ISHR日本部会総会
- Place of Presentation
  九州大学　福岡
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Quantitative Epigenome Mapping Reveals the Differentially Induced Histone H3 Lysine 4 Trimethylation Marks in Pressure-overloaded Failing Hearts.2012
- Author(s)
  Shuichiro Higo, Yoshihiro Asano, Seiji Takashima, Issei Komuro
- Organizer
  Molecular CardiovascularConference II
- Place of Presentation
  北海道赤井川村キロロ
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Quantitative ChIP-sequence Analysis Reveals the Differentially Altered Active Epigenomic States in Murine Pressure-overloaded Failing Hearts.2012
- Author(s)
  Shuichiro Higo, Yoshihiro Asano, Seiji Takashima, Masafumi Kitakaze, Issei Komuro
- Organizer
  第29回ISHR日本部会総会
- Place of Presentation
  九州大学福岡
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Quantitative Epigenome Mapping Reveals the Differentially Induced Histone H3 Lysine 4 Trimethylation Marks in Pressure-overloaded Failing Hearts2012
- Author(s)
  肥後　修一朗
- Organizer
  Molecular Cardiovascular Conference II
- Place of Presentation
  北海道赤井川村キロロ
- Data Source
  KAKENHI-PROJECT-24790757
[Presentation] Quantitative ChIP-Sequence Analysis Reveals the Differentially Altered Active Epigenomic States in Murine Pressure-Overloaded Failing Hearts2012
- Author(s)
  Higo Shuichiro, Asano Yoshihiro, Takashima Seiji, Kitakaze Masafumi, Komuro Issei
- Organizer
  The 29th Annual Meeting of the International Society for Heart Research Japanese Section
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-24591097
[Presentation] Comprehensive quantitative epigenome mapping reveals the differential induction of histone H3 lysine 4 trimethylation marks in pressure-overloaded murine hearts
- Author(s)
  Shuichiro Higo,Yoshihiro Asano, Seiji Takashima, Masafumi Kitakaze, Issei Komuro
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles、USA
- Data Source
  KAKENHI-PROJECT-24591097
[Presentation] Meox1 is a Cell-cycle Oscillator Required for Mitotic Transition and Proliferation in Cardiac Fibroblasts
- Author(s)
  Shuichiro Higo, Yoshihiro Asano, Yuki Masumura, Yasushi Sakata, Masafumi Kitakaze, Seiji Takashima
- Organizer
  BASIC CARDIOVASCULAR SCIENCES 2014 SCIENTIFIC SESSIONS
- Place of Presentation
  Las Vegas, Nevada, USA
- Year and Date
  2014-07-14 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-26860558

1. ASANO Yoshihiro (60527670)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. TSUKAMOTO Osamau (80589151)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
3. 彦惣俊吾 (30423164)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
4. MINAMINO TETSUO (30379234)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. SANADA Shoji (70593797)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TAKASHIMA Seiji (90379272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
7. Sakata Yasushi (00397671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. HAO Hiroyuki (40393243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KATO Hisakazu (30589312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OGITA Hisakazu (50379236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHINTANI Yasunori (20712243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. Yan Yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. TO Seikon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. IMAMURA Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. ASAKURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. NAKANO Astushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
17. MIN Kyung-Duk

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. ITO Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. IHARA Madoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 北風政史

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
21. 浅沼博司

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
22. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 増村雄喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 中山博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 中井淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 新谷紀人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 木岡秀隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
28. 山崎悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
29. 浅井知浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 目加田英輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 清水広介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 小倉尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 吉川信也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 藤尾慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 野地博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 鈴木俊治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 藤川誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higo Shuichiro 肥後 修一朗

HIGO Schuichiro 肥後 修一朗

KATO Hisakazu 加藤 久和

Research Projects

Research Products

Co-Researchers

Development of Human Disease Model of Arrhythmogenic Right Ventricular Cardiomyopathy for Personalized MedicineOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic development targeting molecular basis of dilated-phase hypertrophic cardiomyopathyPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of molecular pathophysiology and identification of therapeutic target in desmosome-related cardiomyopathyOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of upstream therapy targeting molecular basis of refractory cardiomyopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic Application of Genome Editing for Advanced Heart FailurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of simple and noninvasive method to assess the severity of heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular discovery research targeting cardiac remodeling using multi-directional transcriptional profiling and therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

anti-atherosclerotic and anti-cancer effects of AMPK activation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of ER oxidoreductin-1 in cardiovascular remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A New Diagnostics Method for Refractory Heart Failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative Epigenome Mapping to Identify Therapeutic Target in Heart FailurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 心不全のサイエンス ゲノム編集の難治性心筋症医療応用2019

Author(s)

Higo Shuichiro 肥後修一朗

HIGO Schuichiro 肥後修一朗

KATO Hisakazu 加藤久和

[Book] 心不全のサイエンス　ゲノム編集の難治性心筋症医療応用2019

[Book] 心不全のサイエンス　ゲノム編集の難治性心筋症医療応用2019

[Book] 医療応用をめざすゲノム編集　拡張型心筋症におけるゲノム編集治療2018

[Book] 心不全　ゲノム編集2018

[Book] 心不全　ゲノム編集2018