NISHIDA YUYA 西田優也

… Alternative Names

Nishida Yuya 西田優也

西田優也ニシダユウヤ

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Researcher Number	10793440
Other IDs	https://orcid.org/0000-0002-1994-0807
Affiliation (Current)	2026: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2026: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2022 – 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2024: 国立研究開発法人国立循環器病研究センター, 分子薬理部, 室長 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2019: 大阪大学, 医学系研究科, 招へい教員 2017 – 2018: 大阪大学, 医学系研究科, 特任助教(常勤)
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Cardiovascular medicine
Keywords	Principal Investigator アロステリック創薬 / 呼吸鎖 / シトクロムc酸化酵素 / peptide design / ペプチドデザイン / アロステリックペプチド / 膜タンパク質 / ヘムタンパク質 / アロステリック阻害薬 / X線結晶構造解析 … More / クライオ電子顕微鏡 / アロステリック阻害剤 / 抗菌薬 / 薬剤耐性菌 … More Except Principal Investigator cardiac MLCK / キナーゼ活性化機構 / ｃMLCK / サルコメア / ミオシン調節軽鎖キナーゼ / 心不全 Less

デザインされたタンパク質を用いた呼吸鎖複合体IVの活性増強と創薬応用Principal Investigator
- Principal Investigator
  
  西田優也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Cardiovascular Center Research Institute
Identification of Evolutionarily buried Allostery and Application to Antimicrobial Drug DevelopmentPrincipal Investigator
- Principal Investigator
  
  Nishida Yuya
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Cardiovascular Center Research Institute
Identifying antibiotics using the conserved allostery from respiratory complexPrincipal Investigator
- Principal Investigator
  
  Nishida Yuya
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase
- Principal Investigator
  
  Tsukamoto Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Expression of c-jun/c-fos mRNA Indicates Persistent Myocardial Stretch During Asphyxia-Induced Cardiac Arrest2024
- Author(s)
  Yokota Yutaka、Kadowaki Sachiko、Yamazaki Satoru、Nishida Yuya、Shishido Toshiaki、Shimizu Shuji、Kasahara Shingo、Kotani Yasuhiro
- Journal Title
  
  Int. Heart J.
  
  Volume: 65 Issue: 5 Pages: 939-944
- DOI
  10.1536/ihj.24-072
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2024-09-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14525, KAKENHI-PROJECT-22K09391
[Journal Article] Conserved allostery buried inside mitochondrial heme-copper oxidases can generate novel antibiotics2024
- Author(s)
  西田優也、新谷泰範
- Journal Title
  
  生化学
  
  Volume: 96 Issue: 3 Pages: 359-363
- DOI
  10.14952/SEIKAGAKU.2024.960359
- ISSN
  0037-1017
- Year and Date
  2024-06-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-23K14525
[Journal Article] Effects of Interfacial Interactions on Electrocatalytic Activity of Cytochrome c Oxidase in Biomimetic Lipid Membranes on Gold Electrodes2022
- Author(s)
  Kato Masaru、Sano Ryoya、Yoshida Narumi、Iwafuji Masatoshi、Nishiyama Yoshito、Oka Sayuki、Shinzawa-Itoh Kyoko、Nishida Yuya、Shintani Yasunori、Yagi Ichizo
- Journal Title
  
  The Journal of Physical Chemistry Letters
  
  Volume: 13 Issue: 39 Pages: 9165-9170
- DOI
  10.1021/acs.jpclett.2c01765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05124, KAKENHI-PROJECT-22K06130, KAKENHI-PROJECT-21K15443, KAKENHI-PROJECT-21H02921
[Journal Article] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.2022
- Author(s)
  Nishida Y, Yanagisawa S, Morita R, Shigematsu H, Shinzawa-Itoh K, Yuki H, Ogasawara S,　et al
- Journal Title
  
  Nat Commun.
  
  Volume: 13 Issue: 1 Pages: 7591-7591
- DOI
  10.1038/s41467-022-34771-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06130, KAKENHI-PROJECT-22K09391, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-20K03794, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K15443, KAKENHI-PROJECT-21K15776, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-22H04760, KAKENHI-PUBLICLY-22H04800, KAKENHI-PROJECT-21H02914
[Journal Article] AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐1702020
- Author(s)
  Yashirogi Shohei、Nagao Takemasa、Nishida Yuya、Takahashi Yusuke、Qaqorh Tasneem、Yazawa Issei、Katayama Toru、Kioka Hidetaka、Matsui Tsubasa S、Saito Shigeyoshi、Masumura Yuki、Tsukamoto Osamu、Kato Hisakazu、Ueda Hiromichi、Yamaguchi Osamu、Yashiro Kenta、Yamazaki Satoru、Takashima Seiji、Shintani Yasunori
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 1
- DOI
  10.15252/embr.202050949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-21K15443
[Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2019
- Author(s)
  Nagao Takemasa、Shintani Yasunori、Hayashi Takaharu、Kioka Hidetaka、Kato Hisakazu、Nishida Yuya、Yamazaki Satoru、Tsukamoto Osamu、Yashirogi Shohei、Yazawa Issei、Asano Yoshihiro、Shinzawa‐Itoh Kyoko、Imamura Hiromi、Suzuki Takeo、Suzuki Tsutomu、Goto Yu‐ichi、Takashima Seiji
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 1 Pages: 1859-1871
- DOI
  10.1096/fj.201800389r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K22246, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-18H02094, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
[Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 22019
- Author(s)
  Kamikubo Kenta、Kato Hisakazu、Kioka Hidetaka、Yamazaki Satoru、Tsukamoto Osamu、Nishida Yuya、Asano Yoshihiro、Imamura Hiromi、Kawahara Hiroyuki、Shintani Yasunori、Takashima Seiji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 40 Pages: 14562-14573
- DOI
  10.1074/jbc.ra119.008544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K09408, KAKENHI-PUBLICLY-19H05293, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17H03657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
[Presentation] Positive allosteric modulation of cytochrome c oxidase activity2024
- Author(s)
  Yuya Nishida, Takumi Tateno, Takemasa Nagao, Yasunori Shintani
- Organizer
  International Union of Pure and Applied Biophysics 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14525
[Presentation] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial respiratory complex IV2023
- Author(s)
  西田優也、志牟田健、柳澤幸子、森田陸離、伊藤（新澤）恭子、新谷泰範
- Organizer
  第23回日本蛋白質科学会年会 (PSSJ2023)
- Data Source
  KAKENHI-PROJECT-23K14525
[Presentation] ミトコンドリア呼吸鎖複合体IVの新規なアロステリーを利用した病原菌特異的な抗菌薬の創出2023
- Author(s)
  西田優也
- Organizer
  2023年度ミトコンドリア・サイエンス・ワークショップ (MSW2023)
- Data Source
  KAKENHI-PROJECT-23K14525
[Presentation] 呼吸鎖複合体IVの隠されたアロステリック阻害機構と抗菌薬開発への展開2023
- Author(s)
  西田優也
- Organizer
  第94回 SPring-8 先端利用技術ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-23K14525
[Presentation] 呼吸鎖複合体 IV のコア構造に注目した病原菌特異的抗菌薬の探索2022
- Author(s)
  Yuya Nishida, Yasunori Shintani
- Organizer
  日本生体エネルギー研究会第48回討論会
- Data Source
  KAKENHI-PROJECT-21K15443
[Presentation] Evolutionally conserved allostery in heme-copper oxidases can generate pathogen-specific antibiotics2022
- Author(s)
  Yuya Nishida, Yasunori Shintani
- Organizer
  21th European Bioenergetics Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15443
[Presentation] Conserved allostery in heme-copper oxidases can generate pathogen-specific antibiotics2022
- Author(s)
  Yuya Nishida, Yasunori Shintani
- Organizer
  Cell Symposia: Multifaceted Mitochondria (CMIT2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15443
[Presentation] Conserved allostery in heme-copper oxidases2021
- Author(s)
  西田優也
- Organizer
  Chem-Bio Informatics Society Annual Meeting 2021
- Data Source
  KAKENHI-PROJECT-21K15443
[Presentation] 呼吸鎖複合体 IV で見出された新規アロステリック活性調節機構2021
- Author(s)
  西田優也
- Organizer
  第47回生体分子討論会
- Data Source
  KAKENHI-PROJECT-21K15443
[Presentation] A novel allostery in cytochrome c oxidase2021
- Author(s)
  西田優也
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K15443

1. Tsukamoto Osamu (80589151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 新谷泰範 (20712243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 朝野仁裕 (60527670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大谷健太郎 (50470191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 加藤優

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 木岡秀隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NISHIDA YUYA 西田 優也

Nishida Yuya 西田 優也

西田 優也 ニシダ ユウヤ

Research Projects

Research Products

Co-Researchers

デザインされたタンパク質を用いた呼吸鎖複合体IVの活性増強と創薬応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of Evolutionarily buried Allostery and Application to Antimicrobial Drug DevelopmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identifying antibiotics using the conserved allostery from respiratory complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expression of c-jun/c-fos mRNA Indicates Persistent Myocardial Stretch During Asphyxia-Induced Cardiac Arrest2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Conserved allostery buried inside mitochondrial heme-copper oxidases can generate novel antibiotics2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Effects of Interfacial Interactions on Electrocatalytic Activity of Cytochrome c Oxidase in Biomimetic Lipid Membranes on Gold Electrodes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐1702020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 22019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Positive allosteric modulation of cytochrome c oxidase activity2024

Author(s)

Organizer

Data Source

[Presentation] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial respiratory complex IV2023

Author(s)

Organizer

Data Source

[Presentation] ミトコンドリア呼吸鎖複合体IVの新規なアロステリーを利用した病原菌特異的な抗菌薬の創出2023

NISHIDA YUYA 西田優也

Nishida Yuya 西田優也

西田優也ニシダユウヤ