Uto Takuhiro 宇都拓洋

… Alternative Names

UTO Takuhiro 宇都拓洋

宇都拓洋ウトタクヒロ

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Researcher Number	90469396
Other IDs
Affiliation (Current)	2025: 長崎国際大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 長崎国際大学, 薬学部, 教授 2017 – 2023: 長崎国際大学, 薬学部, 准教授 2013 – 2017: 長崎国際大学, 薬学部, 講師 2007 – 2008: 長崎国際大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines / General internal medicine(including psychosomatic medicine) Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Eating habits / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator 生薬 / 甘草 / 標的分子 / 作用機序 / オウゴン / オートファジー / 炎症性サイトカイン / ケラチノサイト / フィラグリン / 天然物 … More / 皮膚バリア / アトピー性皮膚炎 / 黄連 / グリチルリチン酸 / 相互作用 / オウレン / カンゾウ / 生薬エキス / 出芽酵母 / ケミカルジェネティクス / 天然資源系薬学 / 薬学 / (+)-magnolin / 作用機序解析 / メラニン合成促進物質 / 白斑治療 / 丁子 / メラニン合成促進 / シリビニン / マグノリン / 辛夷 / 甘草フラボノイド / スクリーニング / メラニン / 白斑 / 天然化合物特異的モノクローナル抗体 / ベルベリン / フラボノイド / ケミカルバイオロジー / 天然化合物 / リクイリチン / バイカレイン / モノクローナル抗体 / 生薬成分 … More Except Principal Investigator モノクローナル抗体 / 生薬 / 希少難病 / 変死膜タンパク質 / 小胞体 / 疾患モデルマウス / 変異膜たんぱく質 / 神経難病 / 天然医薬資源 / オートファジー / 神経変性疾患 / PMP22 / CMT病 / 変異膜タンパク質 / 甘草の機能性 / 甘草エキス / 3T3-L1 / グリチルレチン酸 / グリチルリチン / リクイリチン / 甘草フラボノイド / 甘草 / ノックアウトエキス / 小型化抗体 / エビデンス / アフィニテイカラム / 活性成分 / ノックアウト漢方 Less

Natural product-based drug discovery for skin barrier dysfunction in atopic dermatitisPrincipal Investigator
- Principal Investigator
  
  宇都拓洋
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Nagasaki International University
Development of innovative treatments for rare and intractable diseases based on natural pharmaceutical resources
- Principal Investigator
  
  Hara Taichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Waseda University
Elucidation of the mechanism of action and the target molecules of ingredients in crude extracts by chemical genetics approach using yeast knock-out strain collectionPrincipal Investigator
- Principal Investigator
  
  UTO Takuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Nagasaki International University
Discovery of natural compounds for the treatment of vitiligo and elucidation of their mechanism of actionPrincipal Investigator
- Principal Investigator
  
  UTO Takuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Natural medicines
- Research Institution
  Nagasaki International University
Investigation for action mechanism of licorice functional flavonoids using a monoclonal antibody.
- Principal Investigator
  
  Fujii Shunsuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  Nagasaki International University
Identification of direct target molecules of bioactive natural compounds using monoclonal antibodies against natural compoundsPrincipal Investigator
- Principal Investigator
  
  UTO Takuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Nagasaki International University
ノックアウト漢方の創製とそのエビデンスに関する研究
- Principal Investigator
  
  SHOYAMA Yukihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Nagasaki International University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 2008

All Journal Article Presentation Patent

[Journal Article] Development of an indirect competitive enzyme-linked immunosorbent assay for formononetin and its application in a cell-based assay using MC3T3-E1 cells2023
- Author(s)
  Fujii Shunsuke、Ohta Tomoe、Ehama Riho、Irikida Mizuki、Nomura Shuichi、Shoyama Yukihiro、Uto Takuhiro
- Journal Title
  
  Food Chemistry
  
  Volume: 403 Pages: 134339-134339
- DOI
  10.1016/j.foodchem.2022.134339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K02149, KAKENHI-PROJECT-19K07145
[Journal Article] Development of Highly Sensitive Chemiluminescence Enzyme Immunostaining Assay to Determine Glycyrrhizin Content Using Anti-glycyrrhizin Monoclonal Antibody2022
- Author(s)
  Fujii Shunsuke、Shoyama Yukihiro、Nomura Shuichi、Uto Takuhiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 10 Pages: 694-698
- DOI
  10.1248/cpb.c22-00405
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K02149, KAKENHI-PROJECT-19K07145
[Journal Article] Immunological Separation of Bioactive Natural Compounds from Crude Drug Extract and Its Application for Cell-Based Studies2021
- Author(s)
  Uto Takuhiro、Ohta Tomoe、Fujii Shunsuke、Shoyama Yukihiro
- Journal Title
  
  Antibodies
  
  Volume: 10 Issue: 4 Pages: 48-48
- DOI
  10.3390/antib10040048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07145
[Journal Article] Applications of Monoclonal Antibodies Against Natural Compounds for Functional Analysis of Crude Drugs2020
- Author(s)
  Takuhiro Uto, Shunsuke Fujii, Seiichi Sakamoto, Tomoe Ohta, Yukihiro Shoyama
- Journal Title
  
  Current Pharmacology Reports
  
  Volume: 6 Issue: 4 Pages: 192-201
- DOI
  10.1007/s40495-020-00224-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07145
[Journal Article] Preparation of Anti-Glycyrrhetinic Acid Monoclonal Antibody for Application in an Indirect Competitive Enzyme-Linked Immunosorbent Assay2018
- Author(s)
  Fujii Shunsuke、Uto Takuhiro、Nomura Shuichi、Shoyama Yukihiro
- Journal Title
  
  Analytical Letters
  
  Volume: 51 Issue: 8 Pages: 1147-1162
- DOI
  10.1080/00032719.2017.1370598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16225
[Journal Article] 甘草含有成分に対するモノクローナル抗体を用いた甘草の品質評価法の開発2017
- Author(s)
  藤井俊輔、宇都拓洋、正山征洋
- Journal Title
  
  アグリバイオ
  
  Volume: 4 Pages: 72-75
- NAID
  40021807148
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K16225
[Journal Article] Simultaneous determination of glycyrrhizin and liquiritin in licorice roots and Kampo medicines by combination enzyme-linked immunosorbent assay using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies.2016
- Author(s)
  Shunsuke Fujii, Osamu Morinaga, Takuhiro Uto, Shuichi Nomura, Yukihiro Shoyama
- Journal Title
  
  Journal of Immunoassay and Immunochemistry
  
  Volume: 28 Issue: 3 Pages: 1-14
- DOI
  10.1080/15321819.2016.1260586
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K16225
[Journal Article] Development of Double Eastern Blotting for Major Licorice Components, Glycyrrhizin and Liquiritin for Chemical Quality Control of Licorice Using anti-Glycyrrhizin and anti-Liquiritin Monoclonal Antibodies2016
- Author(s)
  Shunsuke Fujii, Osamu Morinaga, Takuhiro Uto, Shuichi Nomura, Yukihiro Shoyama
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 64 Issue: 5 Pages: 1087-1093
- DOI
  10.1021/acs.jafc.5b04732
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670373, KAKENHI-PROJECT-25871011, KAKENHI-PROJECT-15K16225
[Journal Article] Functional analysis of bioactive natural compounds using monoclonal antibodies against natural compounds2014
- Author(s)
  Takuhiro Uto
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 134 Pages: 1061-1067
- NAID
  130004693879
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25871011
[Journal Article] Development of eastern blotting technique for sennoside A and B using anti-sennoside A and B monoclonal antibodies2009
- Author(s)
  O. Morinaga, T. Uto, S. Sakamoto, W. Putalun, et al.
- Journal Title
  
  Phytochem. Anal. 20
  
  Pages: 154-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659177
[Journal Article] Micropropagation of Anoectochilus formosanus Hayata in vitro and pharmacological and chemical investigations2008
- Author(s)
  X. M. DU, N. Irino, T. Uto, O. Morinaga, Y. Shoyama, et al
- Journal Title
  
  Current Topics in Phytochem. 9
  
  Pages: 79-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659177
[Patent] メラニン合成促進組成物2017
- Inventor(s)
  正山征洋、宇都拓洋、太田智絵
- Industrial Property Rights Holder
  正山征洋、宇都拓洋、太田智絵
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-149066
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K18905
[Presentation] アルクチゲニンおよびアルクチインに対するモノクローナル抗体を用いた間接競合ELISAの確立2023
- Author(s)
  藤井俊輔、太田智絵、友利桃子、小嶋涼華、野村秀一、宇都拓洋
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07145
[Presentation] シャルコー・マリー・トゥース病治療薬を志向したベルベリン類縁化合物の構造活性相関研究2023
- Author(s)
  宮本怜奈、永松愛美、牛之濱早紀、太田智絵、原太一、宇都拓洋
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07145
[Presentation] ホルモノネチンに対する特異的モノクローナル抗体の作製および間接競合ELISAへの応用2022
- Author(s)
  藤井俊輔、太田智絵、正山征洋、宇都拓洋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07145
[Presentation] スペルミンとスペルミジンバランスによるオートファジー制御機構の解析と機能性食品の開発2022
- Author(s)
  Xie Kun, 矢野敏史, 山越正汰, 太田智絵, 宇都拓洋, 坂井麻衣子, 大西康太, 久保田拓海, 原太一
- Organizer
  日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-20H03408
[Presentation] 甘草エキスに含まれるミトコンドリア機能改善成分の探索2020
- Author(s)
  佐藤美沙希，石橋優美子，髙崎伸也，宇都拓洋，太田一寿
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07145
[Presentation] Analysis of synergistic effects and molecular targets of natural compounds using monoclonal antibodies against natural compounds2019
- Author(s)
  Takuhiro Uto
- Organizer
  7th International Conference on Food Factors (ICoFF2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07145
[Presentation] シリビニンのメラニン合成誘導能とその作用機序解析2018
- Author(s)
  片山幸樹、Bua Siritantiwat、宮嶋祥吾、太田智絵、宇都拓洋、正山征洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18905
[Presentation] マリアアザミ種子成分シリビニンのメラニン合成促進活性とその分子機構解明2018
- Author(s)
  片山幸樹、Bua Siritantiwat、宮嶋祥吾、太田智絵、正山征洋、宇都拓洋
- Organizer
  第2回食薬ヘルスイノベーション研究会
- Data Source
  KAKENHI-PROJECT-16K18905
[Presentation] グリチルレチン酸に対するモノクローナル抗体の作製と高感度ELISAへの応用2017
- Author(s)
  藤井俊輔、宇都拓洋、野村秀一、正山征洋
- Organizer
  日本生薬学会
- Data Source
  KAKENHI-PROJECT-15K16225
[Presentation] Magnolin isolated form Magnolia flower activates melanogenesis; Involvement of p38 and PKA signaling pathways2017
- Author(s)
  Takuhiro Uto, Tomoe Ohta, Yukihiro Shoyama
- Organizer
  Food for Health International Conference 2017 (FOHIC2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18905
[Presentation] 辛夷から単離した（+）-Magnolinのメラニン合成誘導能とその作用機序解析2017
- Author(s)
  宇都拓洋、太田智絵、Nguyen Huu Tung、Kasina Soitanasirikul、久住呂美和、正山征洋
- Organizer
  日本生薬学会第64回年会
- Data Source
  KAKENHI-PROJECT-16K18905
[Presentation] 白斑治療薬開発を目指した天然由来メラニン合成促進物質の探索および作用機序に関する研究（学術奨励賞受賞講演）2017
- Author(s)
  宇都拓洋
- Organizer
  日本生薬学会第64回年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18905
[Presentation] ベルベリンのがん細胞増殖抑制とその作用機序解析2016
- Author(s)
  後藤綾、大久保伸哉、田中宏幸、宇都拓洋、森永紀、正山征洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25871011
[Presentation] リクイリチン及びリクイリチゲニンのメラニン合成誘導能とその作用機序解析2015
- Author(s)
  宇都拓洋、山下明寿、藤井俊輔、森永紀、正山征洋
- Organizer
  日本生薬学会第62回年会
- Place of Presentation
  岐阜
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25871011
[Presentation] 天然化合物に対する特異的モノクローナル抗体を用いた甘草の品質評価法の開発～グリチルリチンとリクイリチンをモデル化合物として～2015
- Author(s)
  藤井　俊輔、森永　紀、野村　秀一、宇都　拓洋、正山　征洋
- Organizer
  長崎栄養改善学会
- Place of Presentation
  長崎国際大学
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15K16225
[Presentation] リクイリチン及びリクイリチゲニンのメラニン合成誘導能とその作用機序解析2015
- Author(s)
  宇都　拓洋、山下　明寿、藤井　俊輔、森永紀、正山　征洋
- Organizer
  日本生薬学会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K16225
[Presentation] Analysis of cellular localization and target molecules of natural compounds using monoclonal antibodies against natural compounds2014
- Author(s)
  Takuhiro Uto, Osamu Morinaga, Yukihiro Shoyama
- Organizer
  第19回日本フードファクター学会
- Place of Presentation
  鹿児島大学
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-25871011
[Presentation] 天然物特異的モノクローナル抗体によるヒト肝癌細胞でのバイカレインの局在及び標的分子解析2013
- Author(s)
  宇都拓洋，Nguyen Huu Tung, 森永紀, 正山征洋
- Organizer
  第60回日本生薬学会年会
- Place of Presentation
  北海道医療大学
- Data Source
  KAKENHI-PROJECT-25871011
[Presentation] 天然物特異的モノクローナル抗体を利用したバイカレインの細胞内局在及び標的分子同定（優秀発表賞）2013
- Author(s)
  宇都拓洋，Nguyen Huu Tung, 森永紀, 正山征洋
- Organizer
  第5回食品薬学シンポジウム
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-25871011
[Presentation] 天然物に対する特異的モノクローナル抗体を用いた生薬成分の機能解析（学術奨励賞）2013
- Author(s)
  宇都拓洋
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎国際大学
- Data Source
  KAKENHI-PROJECT-25871011
[Presentation] Functional analysis of licorice extract using knockout extract prepared by anti- glycyrrhizin MAb2009
- Author(s)
  Y. Shoyama, T. Uto, O. Morinaga
- Organizer
  The second Taiwan-Japan Chinese Medicine Mini Symposium
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2009-03-04
- Data Source
  KAKENHI-PROJECT-19659177
[Presentation] Synergistic suppression of inducible nitric oxide synthase expression by glycyrrhizin in lipopolysaccharide-stimulated murine macrophages2008
- Author(s)
  T. Uto, O. Morinaga, Y. Shoyama
- Organizer
  2008' Shanghai International Symposium for Pharmaceutical Sciences
- Place of Presentation
  Shanghai医薬大学
- Year and Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-19659177

1. SHOYAMA Yukihiro (70037604)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. MORINAGA Osamu (60465771)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. FUJII Shunsuke (10610165)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. Hara Taichi (00392374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 吉崎嘉一 (50393161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OHTA tomoe

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. NGUYEN huu tung

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Uto Takuhiro 宇都 拓洋

UTO Takuhiro 宇都 拓洋

宇都 拓洋 ウト タクヒロ

Research Projects

Research Products

Co-Researchers

Natural product-based drug discovery for skin barrier dysfunction in atopic dermatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative treatments for rare and intractable diseases based on natural pharmaceutical resources

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of action and the target molecules of ingredients in crude extracts by chemical genetics approach using yeast knock-out strain collectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of natural compounds for the treatment of vitiligo and elucidation of their mechanism of actionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for action mechanism of licorice functional flavonoids using a monoclonal antibody.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of direct target molecules of bioactive natural compounds using monoclonal antibodies against natural compoundsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ノックアウト漢方の創製とそのエビデンスに関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of an indirect competitive enzyme-linked immunosorbent assay for formononetin and its application in a cell-based assay using MC3T3-E1 cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Highly Sensitive Chemiluminescence Enzyme Immunostaining Assay to Determine Glycyrrhizin Content Using Anti-glycyrrhizin Monoclonal Antibody2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Immunological Separation of Bioactive Natural Compounds from Crude Drug Extract and Its Application for Cell-Based Studies2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Applications of Monoclonal Antibodies Against Natural Compounds for Functional Analysis of Crude Drugs2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of Anti-Glycyrrhetinic Acid Monoclonal Antibody for Application in an Indirect Competitive Enzyme-Linked Immunosorbent Assay2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 甘草含有成分に対するモノクローナル抗体を用いた甘草の品質評価法の開発2017

Author(s)

Journal Title

NAID

Uto Takuhiro 宇都拓洋

UTO Takuhiro 宇都拓洋

宇都拓洋ウトタクヒロ