Minami Manabu 南学

… Alternative Names

MINAMI Manabu 南学

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Researcher Number	90511907
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 病院, 部長
Affiliation (based on the past Project Information) *help	2017 – 2022: 京都大学, 医学研究科, 准教授 2016: 京都大学, 医学研究科, 講師 2014 – 2015: 京都大学, 医学(系)研究科(研究院), 講師 2011 – 2013: 京都大学, 医学(系)研究科(研究院), 助教 2008 – 2011: Kyoto University, 医学研究科, 助教
Review Section/Research Field	Principal Investigator General pharmacology / Pathological medical chemistry Except Principal Investigator Basic Section 53020:Cardiology-related / General pharmacology / Applied pharmacology
Keywords	Principal Investigator マクロファージ / 慢性炎症 / 翻訳後修飾 / EPRAP / シグナル伝達 / 脳内炎症 / 糖代謝 / ホメオスタシス / 糖新生 / シグナル情報伝達系 … More / シグナル情報伝達 / 細胞内シグナル伝達 / 分子病態学 / 炎症・免疫 … More Except Principal Investigator 慢性炎症 / ApoE knock out mouse / vulnerable plaque / radiation / atherosclerosis / SASP / DNA障害 / ApoEノックアウトマウス / 動物モデル / 放射線障害 / 細胞老化 / 放射線照射 / 虚血性血管障害 / 動脈硬化 / 糖代謝 / マクロファージ / プロスタグランジン / 無過失補償 / 臨床試験・倫理 Less

Identifying the specific marker and development of a novel therapy for radiation-induced atherosclerosis
- Principal Investigator
  
  Yoshida Kazumichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University
Drug discovery targeting EPRAP for chronic inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  Minami Manabu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Role of prostaglandin signaling in the control of glucose homeostasis
- Principal Investigator
  
  YOKODE MASAYUKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Role of EPRAP on the pathophysiology of chronic inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Role of EP4 receptor-associated protein in regulating macrophage activationPrincipal Investigator
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Risk-based protection of participants in un-notified clinical trials No-fault Compensation & Informed Consent-
- Principal Investigator
  
  MURAYAMA Toshinori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto University
Role of a novel anti-inflammatory signaling mediated by EPRAPPrincipal Investigator
- Principal Investigator
  
  MINAMI Manabu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University

[Book] 特集脂質異常症—基礎・臨床研究の最新知見—, 動脈硬化予防における多面的アプローチ(増刊号 71 (3))2013
- Author(s)
  南学
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 特集動脈硬化性疾患予防ガイドライン2012, 4. 動脈硬化性疾患の包括的管理(24 (1))2013
- Author(s)
  南学, 横出正之
- Publisher
  The Lipid
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 特集動脈硬化性疾患予防ガイドライン2012 Update, シリーズ危険因子「家族歴」動脈硬化予防(11 (4))2013
- Author(s)
  南学
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 動脈硬化性疾患予防ガイドライン2012改訂のポイント前編(35(3))2013
- Author(s)
  南学
- Publisher
  都薬雑誌
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 増加する癌外来化学療法循環器系の副作用に注意を—(2013年6月号特別編集版)2013
- Author(s)
  南学
- Publisher
  日経メディカル
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 脂質異常症治療薬の特徴と薬剤使用に際しての留意点服薬指導へのアドバイス(35(5)2013
- Author(s)
  南学
- Publisher
  都薬雑誌
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 動脈硬化性疾患予防ガイドライン2012改訂のポイント後編(35(4)2013
- Author(s)
  南学
- Publisher
  都薬雑誌
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 肥満・動脈硬化の発症における新規マクロファージ活性化調節因子EPRAP/Fem1aの機能解析(33(6))2012
- Author(s)
  南学
- Publisher
  herapeutic Research
- Data Source
  KAKENHI-PROJECT-23590361
[Book] 高齢者における脂質管理・動脈硬化学会からのメッセージ(49 (10))2011
- Author(s)
  南学, 横出正之
- Publisher
  Geratric Med
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apolipoprotein E Knock-Out Mice2021
- Author(s)
  Yu Yamamoto , Manabu Minami, Kazumichi Yoshida , Manabu Nagata , Takeshi Miyata , Tao Yang , Naoki Takayama , Keita Suzuki , Masakazu Okawa, Kiyofumi Yamada, Susumu Miyamoto
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 20 Issue: 14
- DOI
  10.1161/jaha.120.020712
- Data Source
  KAKENHI-PROJECT-20K08446
[Journal Article] EP4 receptor-associated protein (EPRAP) regulates gluconeogenesis in the liver and is associated with hyperglycemia in diabetic mice.2019
- Author(s)
  5.Higuchi S, Fujikawa R, Nakatsuji M, Yasui M, Ikedo T, Nagata M, Mishima K, Irie K, Matsumoto M, Yokode M, Minami M.
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 316 Issue: 3 Pages: E410-E417
- DOI
  10.1152/ajpendo.00035.2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03713, KAKENHI-PROJECT-17K08592
[Journal Article] Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation2019
- Author(s)
  Ikedo Taichi、Kataoka Hiroharu、Minami Manabu、Hayashi Kosuke、Miyata Takeshi、Nagata Manabu、Fujikawa Risako、Yokode Masayuki、Imai Hirohiko、Matsuda Tetsuya、Miyamoto Susumu
- Journal Title
  
  World Neurosurgery
  
  Volume: 129 Pages: e361-e366
- DOI
  10.1016/j.wneu.2019.05.153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19914, KAKENHI-PROJECT-16H03167, KAKENHI-PROJECT-17K08592
[Journal Article] Deficiency in EP4 Receptor?Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease2017
- Author(s)
  Fujikawa Risako、Higuchi Sei、Nakatsuji Masato、Yasui Mika、Ikedo Taichi、Nagata Manabu、Hayashi Kosuke、Yokode Masayuki、Minami Manabu
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 187 Issue: 8 Pages: 1848-1854
- DOI
  10.1016/j.ajpath.2017.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08592, KAKENHI-PROJECT-15K08230
[Journal Article] Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice2017
- Author(s)
  (3)Fujikawa R, Higuchi S, Ikedo T, Nagata M, Hayashi K, Yang T, Miyata T, Yokode M, Minami M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 486 Issue: 2 Pages: 584-588
- DOI
  10.1016/j.bbrc.2017.03.095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J05605, KAKENHI-PROJECT-17K08592, KAKENHI-PROJECT-15K08230
[Journal Article] Dipeptidyl Peptidase‐4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation2017
- Author(s)
  Ikedo Taichi、Minami Manabu、Kataoka Hiroharu、Hayashi Kosuke、Nagata Manabu、Fujikawa Risako、Higuchi Sei、Yasui Mika、Aoki Tomohiro、Fukuda Miyuki、Yokode Masayuki、Miyamoto Susumu
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 6 Issue: 6
- DOI
  10.1161/jaha.116.004777
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08592, KAKENHI-PROJECT-15H04952, KAKENHI-PROJECT-15K08230
[Journal Article] Deficiency in EP4 receptor-associated protein ameliorates abnormal anxiety-like behavior and brain inflammation in a mouse model of Alzheimer’s disease.2017
- Author(s)
  Fujikawa R, S. Higuchi, M. Nakatsuji, M. Yasui, T. Ikedo, M. Nagata, K. Hayashi, M. Yokode, M. Minami.
- Journal Title
  
  Am J Pathol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460338
[Journal Article] EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in mice2016
- Author(s)
  (2)Higuchi S, Fujikawa R, Ikedo T, Hayashi K, Yasui M, Nagata M, Nakatsuji M, Yokode M and Minami M.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 197 Issue: 11 Pages: 4436-4443
- DOI
  10.4049/jimmunol.1502618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J05605, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-15K08230
[Journal Article] EP4 receptor-associated protein in microglia promotes inflammation in the brain2016
- Author(s)
  (1)Risako Fujikawa, Sei Higuchi, Masato Nakatsuji, Mika Yasui, Taichi Ikedo, Manabu Nagata, Masayuki Yokode, and Manabu Minami.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 186 Issue: 8 Pages: 1982-1988
- DOI
  10.1016/j.ajpath.2016.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J05605, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-15K08230
[Journal Article] Expression of Vasohibin-1 in Human Carotid Atherosclerotic Plaque.2015
- Author(s)
  Fukumitsu R, Minami M, Yoshida K, Nagata M, Yasui M, Higuchi S, Fujikawa R, Ikedo T, Yamagata S, Sato Y, Arai H, Yokode M, Miyamoto S.
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 印刷中
- NAID
  130005099293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460338
[Journal Article] EP4 receptor–associated protein in macrophages ameliorates colitis and colitis-associated tumorigenesis.2015
- Author(s)
  Nakatsuji, M., M. Minami*, H. Seno*, M. Yasui, H. Komekado, S. Higuchi, R. Fujikawa, Y. Nakanishi, A. Fukuda, K. Kawada, Y. Sakai, T. Kita, P. Libby, H. Ikeuchi, M. Yokode, and T. Chiba
- Journal Title
  
  PLoS Genet
  
  Volume: 11 Issue: 10 Pages: e1005542-e1005542
- DOI
  10.1371/journal.pgen.1005542
- NAID
  120005947032
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-26293173
[Journal Article] The Prostaglandin E2 Receptor EP4 Regulates Obesity-related Inflammation and Insulin Sensitivity.2015
- Author(s)
  Yasui, M., Y. Tamura, M. Minami*, S. Higuchi, R. Fujikawa, T. Ikedo, M. Nagata, H. Arai, T. Murayama, and M. Yokode.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 8 Pages: e0136304-e0136304
- DOI
  10.1371/journal.pone.0136304
- NAID
  120005678204
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-25500003
[Journal Article] Safety and Anti-tumor Activity of Anti–PD-1 Antibody (Nivolumab: ONO-4538/BMS-936558) in Patients with Platinum-resistant Ovarian Cancer.2015
- Author(s)
  Hamanishi, J., M. Mandai, T. Ikeda, M. Minami, A. Kawaguchi, T. Murayama, M. Kanai, Y. Mori, S. Matsumoto, S. Chikuma, N. Matsumura, K. Abiko, T. Baba, K. Yamaguchi, A. Ueda, Y. Hosoe, S. Morita, M. Yokode, A. Shimizu, T. Honjo, I. Konishi.
- Journal Title
  
  J Clin Oncol
  
  Volume: 33 Issue: 34 Pages: 4015-22
- DOI
  10.1200/jco.2015.62.3397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-26253080, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-25462590, KAKENHI-PROJECT-26861324, KAKENHI-PROJECT-25293069, KAKENHI-PROJECT-26293359, KAKENHI-PROJECT-25500003
[Journal Article] 動脈硬化予防における多面的アプローチ2013
- Author(s)
  南学
- Journal Title
  
  日本臨床　増刊号
  
  Volume: 71 Pages: 36-40
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] 動脈硬化性疾患の包括的管理2013
- Author(s)
  南学、横出正之
- Journal Title
  
  The Lipid
  
  Volume: 24 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] An international survey of physicians regarding clinical trials: a comparison between Kyoto University Hospital and Seoul National University Hospital.2013
- Author(s)
  Ito-Ihara T, Hong JH, Kim OJ, Sumi E, Kim SY, Tanaka S, Narita K, Hatta T, Choi EK, Choi KJ, Miyagawa T, Minami M, Murayama T, Yokode M.
- Journal Title
  
  BMC Med Res Methodol.
  
  Volume: 13 Issue: 1 Pages: 130-130
- DOI
  10.1186/1471-2288-13-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-25500003
[Journal Article] 動脈硬化性疾患予防ガイドライン2012 Update「家族歴」2013
- Author(s)
  南学
- Journal Title
  
  動脈硬化予防
  
  Volume: 11 Pages: 119-120
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice2012
- Author(s)
  Tamura, Y., T. Murayama, M. Minami, T. Matsubara, M. Yokode, H. Arai
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 19 (7)(PMID: 22498767) Pages: 608-618
- NAID
  130004444694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice2012
- Author(s)
  Tamura, Y., T. Murayama, M. Minami, T. Matsubara, M. Yokode, and H. Arai.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 19 Issue: 7 Pages: 608-618
- DOI
  10.5551/jat.11312
- NAID
  130004444616
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-24790227
[Journal Article] 肥満･動脈硬化の発症における新規マクロファージ活性化調節因子EPRAP/Fem1aの機能解析2012
- Author(s)
  南学
- Journal Title
  
  Therapeutic Research
  
  Volume: 33 Pages: 821-823
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Differential effect of statins on diabetic nephropathy in db/db mice.2011
- Author(s)
  Tamura, Y., T. Murayama, M. Minami, M. Yokode, H. Arai.
- Journal Title
  
  Int J Mol Med
  
  Volume: 28 Pages: 683-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] Differential effect of statins on diabetic nephropathy in db/db mice2011
- Author(s)
  Tamura Y, Murayama T, Minami M, Yokode M, Arai H.
- Journal Title
  
  Int J Mol Med
  
  Volume: 28 Pages: 683-687
- DOI
  10.3892/ijmm.2011.769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590592, KAKENHI-PROJECT-23590361
[Journal Article] COX-2 inhibition alters the phenotype of tumor associated macrophages from M2 to M1 in ApcMin/+ mouse polyps2011
- Author(s)
  Nakanishi Y, Seno H, Kawada M, et al
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(9) Issue: 9 Pages: 1333-1339
- DOI
  10.1093/carcin/bgr128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J40033, KAKENHI-PROJECT-10J02434, KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-22790642, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590937
[Journal Article] SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation2011
- Author(s)
  Uza N, Nakase H, Yamamoto S, Yoshino T, Takeda Y, Ueno S, Inoue S, Mikami S, Matsuura M, Shimaoka T, Kume N, Minami M, Yonehara S, Ikeuchi H, Chiba T
- Journal Title
  
  Gut
  
  Volume: 60 Issue: 11 Pages: 1494-1505
- DOI
  10.1136/gut.2010.221879
- NAID
  120003497105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-21590810, KAKENHI-PROJECT-23590361, KAKENHI-PROJECT-23590940
[Journal Article] The unique system for 'Unnotified Clinical Trials to the Authority' in Japan2011
- Author(s)
  Murayama T, Sumi E, Minami M, Ihara T, Yokode M
- Journal Title
  
  Clinical Trials
  
  Volume: 8 Pages: 521-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590592
[Journal Article] SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation.2011
- Author(s)
  Uza, N, H. Nakase, S. Yamamoto, T. Yoshino, Y. Takeda, S. Ueno, S. Inoue, S. Mikami, M. Matsuura, T. Shimaoka, N. Kume, M. Minami, S. Yonehara, H. Ikeuchi, T. Chiba.
- Journal Title
  
  Gut
  
  Volume: 60 Pages: 1494-505
- NAID
  120003497105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps.2011
- Author(s)
  Nakanishi, Y., M. Nakatsuji, H. Seno, S. Ishizu, R. Akitake-Kawano, K. Kanda, T. Ueo, H. Komekado, M. Kawada, M. Minami, T. Chiba.
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Pages: 1333-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590361
[Journal Article] C-C Chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice.2010
- Author(s)
  Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H.
- Journal Title
  
  J Arterioscler Thromb 17
  
  Pages: 219-228
- NAID
  130004444414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590592
[Journal Article] C-C Chemokine Receptor 2 Inhibitor Improves Diet-Induced Development of Insulin Resistance and Hepatic Steatosis in Mice2010
- Author(s)
  Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 17 Issue: 3 Pages: 219-228
- DOI
  10.5551/jat.3368
- NAID
  130004444414
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590592
[Journal Article] C-C chemokine receptor 2inhibitor improves diet-induceddevelopment of insulin resistance andhepatic steatosis in mice2010
- Author(s)
  Tamura, Y., M. Sugimoto, T. Murayama, M. Minami, Y. Nishikaze, H. Ariyasu, T. Akamizu, T. Kita, M. Yokode, H. Arai
- Journal Title
  
  JAtheroscler Thromb 17
  
  Pages: 219-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] EP4受容体結合蛋白EPRAP/FEM1Aを中心とする新規抗炎症性分子ネットワークの心血管病発生における意義2009
- Author(s)
  南学
- Journal Title
  
  Therapeutic Research 30(6)
  
  Pages: 927-931
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] 脂質異常のないプラーク形成の機序2009
- Author(s)
  南学, 横出正之
- Journal Title
  
  日本医事新報 4460(7)
  
  Pages: 76-77
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] CC Chemokine Receptor-1 Activates Intimal Smooth Muscle-Like Cells in Graft Arterial Disease2009
- Author(s)
  Shimizu, K., M. Minami, R. Shubiki, M.L. Ilasaca, L. MacFarlane, Y. Asami, Y. Li, R.N. Mitchell, P. Libby
- Journal Title
  
  Circulation 120
  
  Pages: 1800-1813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] EP4受容体結合蛋白EPRAP/FEM1Aを中心とする新規抗炎症性分子ネットワークの心血管病発生における意義2009
- Author(s)
  南学
- Journal Title
  
  Therapeutic Research 30(6号)
  
  Pages: 927-931
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] CCR2の薬理的阻害は食餌誘導性肥満マウスにおけるインスリン抵抗性と肝脂肪蓄積を改善する2008
- Author(s)
  荒井秀典, 田村行織, 村山敏典, 南学, 北徹, 横出正之
- Journal Title
  
  肥満研究 14
  
  Pages: 159-159
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis2008
- Author(s)
  Okamoto, Y., E.J. Folco M. Minami, A.K. Wara, M.W. Feinberg, G.K. Sukhova, R.A. Colvin, S. Kihara, T. Funahashi, A.D. Luster, P. Libby
- Journal Title
  
  CircRes 102
  
  Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890111
[Journal Article] Saji. 2008. Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque
- Author(s)
  Kuge, Y., N. Kume, S. Ishino, N. Takai, Y. Ogawa, T. Mukai, M. Minami, M. Shiomi, H. Saji
- Journal Title
  
  J Nucl Med 49
  
  Pages: 1677-1685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890111
[Presentation] 放射線照射はマウス頚動脈プラークの細胞老化を促進させる2021
- Author(s)
  山本優、吉田和道、南学、鈴木啓太、高山直樹、鈴木芽、大川将和、山田清文、宮本享
- Organizer
  第80回　日本脳神経外科学会
- Data Source
  KAKENHI-PROJECT-20K08446
[Presentation] 放射線誘発性頚動脈狭窄症のモデルマウス作成2020
- Author(s)
  山本優・吉田和道・南学・鈴木啓太・高山直樹・大川将和・山田清文・宮本享
- Organizer
  日本脳神経外科学会第79回学術集会
- Data Source
  KAKENHI-PROJECT-20K08446
[Presentation] 動脈硬化の新たなリスク因子としてのがん・がん診療2019
- Author(s)
  南　学
- Organizer
  第51回日本動脈硬化学会
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] がん治療と脳心血管アンチエイジング2019
- Author(s)
  南　学
- Organizer
  脳心血管抗加齢研究会2019
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] 脂質異常症治療薬の特徴と薬物治療における留意点2019
- Author(s)
  南　学
- Organizer
  第51回日本動脈硬化学会
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] 抗がん剤の循環器系への副作用-Onco-Cardiologyの国内外の現状と課題2018
- Author(s)
  南　学
- Organizer
  第9回日本安全性薬理研究会学術年会
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] Important Adverse Effects of Molecular-Targeting Drugs in Aspects of Cardio-Oncology.2018
- Author(s)
  Minami M
- Organizer
  7th DIA Cardiac Safety Workshop in Japan
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] Prostaglandin E Receptor Type 4 Signaling in Chronic Inflammation and Metabolic Disorders.2018
- Author(s)
  Minami M
- Organizer
  JAPAN-ASEAN Seminar 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] 委員会の運用における課題と対策2018
- Author(s)
  南　学
- Organizer
  滋賀医科大学臨床研究開発センター臨床研究法・改正指針への対応ワークショップ
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] 委員会の運用における課題と対策2018
- Author(s)
  南　学
- Organizer
  滋賀医科大学臨床研究開発センター臨床研究法・改正指針への対応ワークショップ
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] 抗がん剤の循環器系への副作用-Onco-Cardiologyの国内外の現状と課題2018
- Author(s)
  南　学
- Organizer
  第9回日本安全性薬理研究会学術年会
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] 学際領域として重要さをますOnco-Cardiology-その歴史と現状-2018
- Author(s)
  南　学
- Organizer
  第66回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] EPRAP in microglia promotes inflammation via MKK4-mediated signaling pathway2017
- Author(s)
  藤川　理沙子、樋口　聖、南　学、安井　美加、池堂　太一、永田　学、横出　正之
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎、長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] EPRAP欠損マウスは精神疾患様の行動異常を示す2017
- Author(s)
  藤川理沙子、南学、横出正之
- Organizer
  第26回神経行動薬理若手研究者の集い
- Place of Presentation
  福大メディカルホール（福岡、福岡市）
- Year and Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EPRAP欠損マウスは精神疾患様の行動異常を示す2017
- Author(s)
  藤川　理沙子、南　学、横出　正之
- Organizer
  第26回神経行動薬理若手研究者の集い
- Place of Presentation
  福大メディカルホール（福岡、福岡市）
- Year and Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] Cardio-Oncologyとは2017
- Author(s)
  南　学
- Organizer
  第65回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-17K08592
[Presentation] EPRAP in microglia promotes inflammation via MKK4-mediated signaling pathway2017
- Author(s)
  藤川理沙子、樋口聖、南学、安井美加、池堂太一、永田学、横出正之
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎、長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] Cardio-Oncologyとは2017
- Author(s)
  南　学
- Organizer
  第65回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] Onco-Cardiologyの国内外の現状と早期診断におけるバイオマーカーの有用性2016
- Author(s)
  南学
- Organizer
  第64回日本心臓病学会
- Place of Presentation
  東京国際フォーラム（東京、千代田区）
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] Onco-Cardiologyの国内外の現状と早期診断におけるバイオマーカーの有用性2016
- Author(s)
  南　学
- Organizer
  第64回日本心臓病学会
- Place of Presentation
  東京国際フォーラム（東京、千代田区）
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] 膵臓マクロファージによる膵β細胞の慢性炎症におけるEP4シグナルの役割2015
- Author(s)
  安井美加、南学、橫出正之
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会合同大会（BMB2015）
- Place of Presentation
  神戸国際会議場 (神戸・兵庫)
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EP4受容体活性化による2型糖尿病マウスのインスリン抵抗性改善機構2015
- Author(s)
  安井美加、南学、橫出正之
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関 (下関・山口)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] ミクログリアのEPRAPは炎症を促進する2015
- Author(s)
  藤川理沙子、南学、樋口聖、横出正之
- Organizer
  第17回ブレインサイエンス研究会
- Place of Presentation
  休暇村志賀島 (福岡・福岡)
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] マクロファージのEP4受容体関連タンパクEPRAPは糖新生を調節する2015
- Author(s)
  樋口聖, 南学, 藤川理沙子, 安井美加, 池堂太一, 永田学, 橫出正之
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋、愛知
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EP4受容体細胞内結合分子EPRAPはPP2Aにより脱リン酸化されることで抗炎症作用を示す2015
- Author(s)
  藤川理沙子, 樋口聖, 南学, 安井美加, 池堂太一, 永田学, 橫出正之
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋、愛知
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] 薬剤性心毒性の臨床的重要性2015
- Author(s)
  南学
- Organizer
  第79回日本循環器学会
- Place of Presentation
  大阪国際会議場 (大阪・大阪)
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EP4 receptor–associated protein (EPRAP) deficient mice exhibited behavioral abnormalities.2015
- Author(s)
  Fujikawa, R., M. Minami, S. Higuchi, M. Yasui, T. Ikedo, M. Nagata, M. Yokode
- Organizer
  Neuroscience 2015 (Annual Meeting of Society for Neuroscience)
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EP4受容体活性化による2型糖尿病マウスのインスリン抵抗性改善機構2015
- Author(s)
  安井　美加, 南　学, 橫出　正之
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関（山口）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] 膵臓マクロファージによる膵β細胞の慢性炎症におけるEP4シグナルの役割2015
- Author(s)
  安井　美加, 南　学, 橫出　正之
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会合同大会（BMB2015）
- Place of Presentation
  神戸（兵庫）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08230
[Presentation] EP4 receptor associated protein (EPRAP) in microglia promotes inflammation in the central nervous system2014
- Author(s)
  藤川理沙子, 南学, 樋口聖, 安井美加, 池堂太一, 永田学, 橫出正之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台(Oral presentation)
- Year and Date
  2014-03-19
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] EP4 receptor regulates obesity-related Inflammation and insulin sensitivity.2014
- Author(s)
  Yasui, M., M. Minami, M. Yokode
- Organizer
  The 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress (MSDA 2014)
- Place of Presentation
  Kyoto, Kyoto, Japan
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EP4 receptor-associated protein (EPRAP) in microglia promotes inflammation in the brain.2014
- Author(s)
  Fujikawa, R., M. Minami, S. Higuchi, M. Yasui, T. Ikedo, M. Nagata, M. Yokode
- Organizer
  Neuroscience2014 (Annual Meeting of Society for Neuroscience)
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EPRAP欠損マウスは注意欠陥・多動性症候群様の行動異常を示す2014
- Author(s)
  藤川理沙子, 南学, 樋口聖, 横出正之
- Organizer
  第16回ブレインサイエンス研究会
- Place of Presentation
  沖縄、沖縄
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] EP4 receptor associated protein (EPRAP) in macrophages protects against bleomycin induced pulmonary inflammation in mice2014
- Author(s)
  樋口聖, 南学, 中辻正人, 藤川理沙子, 安井美加, 村山敏典, 橫出正之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台(Oral presentation)
- Year and Date
  2014-03-19
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of EP4 signaling in obesity-related inflammation.2014
- Author(s)
  Yasui, M., M. Minami, M. Yokode
- Organizer
  The 18th International Vascular Biology Meeting (IVBM2014)
- Place of Presentation
  Kyoto, Kyoto, Japan
- Year and Date
  2014-04-17
- Data Source
  KAKENHI-PROJECT-26460338
[Presentation] がん化学療法の進歩と心血管合併症-分子標的治療時代の循環器マネージメントのあり方-2013
- Author(s)
  南学
- Organizer
  第77回日本循環器学会
- Place of Presentation
  横浜(モーニングレクチャー)
- Year and Date
  2013-03-17
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] The role of EP4 receptor associated protein in brain2013
- Author(s)
  Fujikawa R., M. Minami, S. Higuchi, M. Yasui, M. Yokode
- Organizer
  第15回ブレインサイエンス研究会
- Place of Presentation
  博多(福岡)(Oral presentation)
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of EP4-EPRAP signaling in obesity and diabetes–肥満や2型糖尿病におけるEP4受容体およびEPRAPの機能解析–2013
- Author(s)
  安井美加, 南学, 樋口聖, 橫出正之
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京(Poster presentation)
- Year and Date
  2013-07-19
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of EP4 signaling in obesity-related inflammation–肥満に伴う慢性炎症におけるEP4受容体の機能解析–2013
- Author(s)
  Yasui, M., M. Minami, M. Yokode.
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸(Poster presentation)
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of EP4-EPRAP signaling in obesity and diabetes2013
- Author(s)
  Yasui, M., M. Minami, M. Yokode
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  博多(福岡)(Oral presentation)
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of bioactive eicosanoid signaling in atherosclerosis and insulin resistance2011
- Author(s)
  Minami, M., M. Yokode
- Organizer
  第19回日本血管生物医学会
- Place of Presentation
  東京(シンポジウム指定講演)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of bioactive eicosanoid signaling in atherosclerosis and insulin resistance.2011
- Author(s)
  南　学
- Organizer
  第19回日本血管生物医学会
- Place of Presentation
  東京ステーションコンファレンス（東京都）
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] CCR2阻害はマウスにおける食餌誘導性のインスリン抵抗性と肝脂肪蓄積を改善する2010
- Author(s)
  田村行識, 村山敏典, 南学, 北徹, 横出正之, 荒井秀典
- Organizer
  第44回日本成人病(生活習慣病)学会
- Place of Presentation
  東京
- Year and Date
  2010-01-09
- Data Source
  KAKENHI-PROJECT-20890111
[Presentation] Prostaglandin E receptor type 4-associated protein (EPRAP) interacts directly with NF-| B1 p105 and attenuates macrophage activation2009
- Author(s)
  南学
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-20890111
[Presentation] Prostaglandin E receptor type 4-associated protein (EPRAP) interacts directly with NF-κB1 p105 and attenuates macrophage activation2009
- Author(s)
  Minami, M., M. Yokode, P. Libby
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-20890111
[Presentation] マクロファージにおける炎症ストレス制御2008
- Author(s)
  南学
- Organizer
  第40回日本動脈硬化学会
- Place of Presentation
  つくば
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20890111
[Presentation] Novel anti-inflammatory signaling in macropahges2008
- Author(s)
  南学
- Organizer
  第40回日本動脈硬化学会総会・学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20890111
[Presentation] EP4 receptor–associated protein (EPRAP) in microglia promotes inflammation in the central nervous system.
- Author(s)
  藤川理沙子, 南学, 樋口聖, 安井美加, 池堂太一, 永田学, 橫出正之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of EP4 signaling in obesity-related inflammation –肥満に伴う慢性炎症におけるEP4 受容体の機能解析–
- Author(s)
  Yasui, M., M. Minami, M. Yokode
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] Role of EP4-EPRAP signaling in obesity and diabetes–肥満や２型糖尿病におけるEP4 受容体およびEPRAP の機能解析–
- Author(s)
  安井美加, 南学, 樋口聖, 橫出正之
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-23590361
[Presentation] EP4 receptor–associated protein (EPRAP) in macrophages protects against bleomycin–induced pulmonary inflammation in mice.
- Author(s)
  樋口聖, 南学, 中辻正人, 藤川理沙子, 安井美加, 村山敏典, 橫出正之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-23590361

1. YOKODE Masayuki (20252447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. SENO Hiroshi (90335266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. MURAYAMA Toshinori (30378765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. NISHIMURA Hiromi (10359440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAMEI Kaeko (00214544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Yoshida Kazumichi (90598921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. NAKATSUJI Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. YASUI Mika

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. FUJIKAWA Risako

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. HIGUCHI Sei

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
11. FUKUMITSU Ryu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. IKEDO Taichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
13. NAGATA Manabu

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
14. HAYASHI Kosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. MIYATA Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YANG Tao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MATSUMOTO Michihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. IMAI Hirohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 千葉勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 松田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Minami Manabu 南 学

MINAMI Manabu 南 学

Research Projects

Research Products

Co-Researchers

Identifying the specific marker and development of a novel therapy for radiation-induced atherosclerosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery targeting EPRAP for chronic inflammatory diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of prostaglandin signaling in the control of glucose homeostasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of EPRAP on the pathophysiology of chronic inflammatory diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of EP4 receptor-associated protein in regulating macrophage activationPrincipal Investigator

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Risk-based protection of participants in un-notified clinical trials No-fault Compensation & Informed Consent-

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Role of a novel anti-inflammatory signaling mediated by EPRAPPrincipal Investigator

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[Book] 特集脂質異常症—基礎・臨床研究の最新知見—, 動脈硬化予防における多面的アプローチ(増刊号 71 (3))2013

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[Book] 特集動脈硬化性疾患予防ガイドライン2012, 4. 動脈硬化性疾患の包括的管理(24 (1))2013

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[Book] 特集動脈硬化性疾患予防ガイドライン2012 Update, シリーズ危険因子「家族歴」動脈硬化予防(11 (4))2013

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[Book] 動脈硬化性疾患予防ガイドライン2012改訂のポイント前編(35(3))2013

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[Book] 増加する癌外来化学療法循環器系の副作用に注意を—(2013年6月号特別編集版)2013

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[Book] 脂質異常症治療薬の特徴と薬剤使用に際しての留意点服薬指導へのアドバイス(35(5)2013

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[Book] 動脈硬化性疾患予防ガイドライン2012改訂のポイント後編(35(4)2013

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[Book] 肥満・動脈硬化の発症における新規マクロファージ活性化調節因子EPRAP/Fem1aの機能解析(33(6))2012

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[Book] 高齢者における脂質管理・動脈硬化学会からのメッセージ(49 (10))2011

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Minami Manabu 南学

MINAMI Manabu 南学

[Journal Article] EP4 receptor–associated protein in macrophages ameliorates colitis and colitis-associated tumorigenesis.2015

[Journal Article] Safety and Anti-tumor Activity of Anti–PD-1 Antibody (Nivolumab: ONO-4538/BMS-936558) in Patients with Platinum-resistant Ovarian Cancer.2015