Nobusue Hiroyuki 信末博行

… Alternative Names

NOBUSUE HIROYUKI 信末博行

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Researcher Number	90525685
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 腫瘍医学研究センター, 講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 藤田医科大学, 腫瘍医学研究センター, 講師 2022 – 2023: 藤田医科大学, がん医療研究センター, 講師 2021: 藤田医科大学, その他部局等, 講師 2016 – 2021: 慶應義塾大学, 医学部(信濃町), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 55020:Digestive surgery-related / Tumor biology
Keywords	Principal Investigator 骨肉腫 / アクチン細胞骨格 / 薬剤耐性 / MKL1 / がん幹細胞 / 上皮-間葉転換 / がん転移 / がん浸潤 / 間葉系細胞 / 転移 … More / 細胞運動 / 癌幹細胞 / 脂肪分化 / 分化制御 … More Except Principal Investigator 腫瘍微小環境 / 腫瘍関連線維芽細胞 / がん微小環境 / アクチン / MKL1 / がん関連線維芽細胞 / 癌関連線維芽細胞 / アクチン細胞骨格 / 薬剤耐性 / 食道癌 / 脂肪細胞 / Rhoキナーゼ阻害剤 / 分化 / 微小環境 / MKL / 骨肉腫 Less

アクチン結合性転写調節因子MKL1活性化を起点とするがん幹細胞薬剤耐性機構の解明Principal Investigator
- Principal Investigator
  
  信末博行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fujita Health University
Elucidation of adipocyte-to-cancer-associated fibroblast conversion mechanism and establishment of strategies to control cancer microenvironment
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Fujita Health University
Overcoming the drug resistance through drug repositioning in esophageal cancer
- Principal Investigator
  
  川久保博文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Keio University
Elucidation of the mechanism of drug resistance in cancer stem cells regulated by actin cytoskeleton dynamics and therapeutic strategies based on this mechanismPrincipal Investigator
- Principal Investigator
  
  Nobusue Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fujita Health University
Elucidation of the molecular mechanism of cancer-related fibroblast induction and regulation of the tumor microenvironment based on its inhibition
- Principal Investigator
  
  Saya Hideyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Fujita Health University
  Keio University
Elucidation of master regulators that determine the acquisition of metastatic phenotype in cancer cells and suppression of metastasis based on its controlPrincipal Investigator
- Principal Investigator
  
  NOBUSUE HIROYUKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Keio University
Elucidation of underlyingmechanism of MKL1-mediated induction of cancer associated fibroblasts and its clinical applications
- Principal Investigator
  
  Saya Hideyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Therapeutic strategies for cancer stem cells by regulating cellular differentiation based on actin dynamicsPrincipal Investigator
- Principal Investigator
  
  NOBUSUE HIROYUKI
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Growth Transformation of B Cells by Epstein-Barr Virus Requires <i>IMPDH2</i> Induction and Nucleolar Hypertrophy2023
- Author(s)
  Sugimoto Atsuko、Watanabe Takahiro、Matsuoka Kazuhiro、Okuno Yusuke、Yanagi Yusuke、Narita Yohei、Mabuchi Seiyo、Nobusue Hiroyuki、Sugihara Eiji、Hirayama Masaya、Ide Tomihiko、Onouchi Takanori、Sato Yoshitaka、Kanda Teru、Saya Hideyuki、Iwatani Yasumasa、Kimura Hiroshi、Murata Takayuki
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 4
- DOI
  10.1128/spectrum.00440-23
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07090, KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-22K10520, KAKENHI-PROJECT-23K06568, KAKENHI-PROJECT-21K07131, KAKENHI-PROJECT-21K15449, KAKENHI-PROJECT-22KJ2977, KAKENHI-PROJECT-23K24140, KAKENHI-PROJECT-23K24144
[Journal Article] Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis2022
- Author(s)
  Uetaki Megumi、Onishi Nobuyuki、Oki Yoshinao、Shimizu Takatsune、Sugihara Eiji、Sampetrean Oltea、Watanabe Takashi、Yanagi Hisano、Suda Kiyoshi、Fujii Hiroya、Kano Koichiro、Saya Hideyuki、Nobusue Hiroyuki
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 33 Issue: 9
- DOI
  10.1091/mbc.e21-12-0609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07131, KAKENHI-PROJECT-22K07177, KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20K07600
[Journal Article] Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo2022
- Author(s)
  Shimizu Takatsune、Sugihara Eiji、Takeshima Hideyuki、Nobusue Hiroyuki、Yamaguchi Rui、Yamaguchi-Iwai Sayaka、Fukuchi Yumi、Ushijima Toshikazu、Muto Akihiro、Saya Hideyuki
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 22 Pages: 3614-3614
- DOI
  10.3390/cells11223614
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07131, KAKENHI-PROJECT-21K07134, KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00518
[Journal Article] MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo2021
- Author(s)
  Shimizu Takatsune、Kimura Kiyomi、Sugihara Eiji、Yamaguchi‐Iwai Sayaka、Nobusue Hiroyuki、Sampetrean Oltea、Otsuki Yuji、Fukuchi Yumi、Saitoh Kaori、Kato Keiko、Soga Tomoyoshi、Muto Akihiro、Saya Hideyuki
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: - Issue: 12 Pages: 2732-2743
- DOI
  10.1002/jor.25023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07243, KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21K07131
[Journal Article] Oncogenic KRAS?expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice2021
- Author(s)
  Kasuga Akiyoshi、Semba Takashi、Sato Ryo、Nobusue Hiroyuki、Sugihara Eiji、Takaishi Hiromasa、Kanai Takanori、Saya Hideyuki、Arima Yoshimi
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 5 Pages: 1822-1838
- DOI
  10.1111/cas.14703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07243
[Journal Article] Targeting of cancer stem cells by differentiation therapy2020
- Author(s)
  Arima Yoshimi、Nobusue Hiroyuki、Saya Hideyuki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 8 Pages: 2689-2695
- DOI
  10.1111/cas.14504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07243
[Journal Article] The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics2020
- Author(s)
  Kunitomi H, Oki Y, Onishi N, Kano K, Banno K, Aoki D, Saya H, Nobusue H
- Journal Title
  
  Genes to Cells
  
  Volume: 25 Issue: 3 Pages: 165-174
- DOI
  10.1111/gtc.12747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07243, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-19K06444
[Journal Article] Rock inhibition suppresses osteosarcoma tumorigenesis by inducing terminal adipocyte differentiation in chemoresistant stemlike cells2019
- Author(s)
  1.Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
- Journal Title
  
  Cancer Research
  
  Volume: in press Issue: 12 Pages: 3088-3099
- DOI
  10.1158/0008-5472.can-18-2693
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H04355, KAKENHI-PROJECT-16H06276
[Journal Article] ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells2019
- Author(s)
  Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
- Journal Title
  
  Cancer Research
  
  Volume: 79 Pages: 3088-3099
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07243
[Journal Article] Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.2017
- Author(s)
  Kamel WA, Sugihara E, Nobusue H, Yamaguchi-Iwai S, Onishi N, Maki K, Fukuchi Y, Matsuo K, Muto A, Saya H, Shimizu T.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 16 Pages: 182-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18426
[Patent] 治療抵抗性がん細胞制御剤及び抗がん剤の抗腫瘍作用増強剤2021
- Inventor(s)
  佐谷秀行, 信末博行
- Industrial Property Rights Holder
  佐谷秀行, 信末博行
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-214001
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K07131
[Presentation] ROCK阻害剤ファスジルは治療抵抗性骨肉腫細胞において化学療法による抗腫瘍効果を高める2023
- Author(s)
  信末博行、清水孝恒、上瀧萌、住吉清香、近藤由佳、山田勢至、塚本徹哉、佐谷秀行
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07131
[Presentation] Therapeutic strategies based on actin cytoskeleton dynamics for targeting chemoresistant osteosarcoma stem cells2022
- Author(s)
  信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
- Organizer
  第12回日米癌合同会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07131
[Presentation] Therapeutic strategies based on actin cytoskeleton dynamics for targeting chemoresistant osteosarcoma stem cells2022
- Author(s)
  信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
- Organizer
  第12回日米癌合同会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00518
[Presentation] Inhibition of MKL1 enhances the effects of anticancer drugs in chemoresistant osteosarcoma cells2022
- Author(s)
  信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H00518
[Presentation] Inhibition of MKL1 enhances the effects of anticancer drugs in chemoresistant osteosarcoma cells2022
- Author(s)
  信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07131
[Presentation] Therapeutic strategies based on actin cytoskeleton dynamics for targeting chemoresistant osteosarcoma stem cells2021
- Author(s)
  信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07131
[Presentation] がん幹細胞を標的としたアクチン細胞骨格動態に基づく新規治療法の開発2020
- Author(s)
  信末博行, 佐谷秀行
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07243
[Presentation] Therapeutic strategies for chemoresistant stemlike osteosarcoma cells by inducing terminal adipocyte differentiation based on actin dynamics2019
- Author(s)
  Nobusue H, Takahashi N, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07243
[Presentation] ROCK阻害剤は化学療法抵抗性の骨肉腫細胞において脂肪細胞への終末分化を誘導し腫瘍形成性を抑制する2019
- Author(s)
  信末博行
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07243
[Presentation] ROCK阻害剤は骨肉腫幹細胞の脂肪細胞への終末分化を誘導することで腫瘍形成性を抑制する2018
- Author(s)
  信末博行, 高橋信博, 清水孝恒, 杉原英志, 大西伸幸, 山口さやか, 國富晴子, 佐谷秀行
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07243
[Presentation] Therapeutic strategies for osteosarcoma stem cells by regulating adipocyte differentiation based on actin dynamics2017
- Author(s)
  Hiroyuki Nobusue, Nobuhiro Takahashi, Haruko Kunitomi, Eiji Sugihara, Takatsune Shimizu, Nobuyuki Onishi, Sayaka Yamaguchi-Iwai, Hideyuki Saya
- Organizer
  ASCB/EMBO 2017 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18426
[Presentation] Therapeutic strategies for osteosarcoma stem cells by regulating adipocyte differentiation based on actin dynamics2017
- Author(s)
  Hiroyuki Nobusue, Nobuhiro Takahashi, Nobuyuki Onishi, Takatsune Shimizu, Eiji Sugihara, Yoshinao Oki, Koichi Akashi, Koichiro Kano, Hideyuki Saya
- Organizer
  American Association for Cancer Research Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18426
[Presentation] Therapeutic strategies for osteosarcoma stem cells by regulating adipocyte differentiation based on actin dynamics2016
- Author(s)
  Hiroyuki Nobusue, Nobuhiro Takahashi, Nobuyuki Onishi, Takatsune Shimizu, Eiji Sugihara, Yoshinao Oki, Tatsuyuki Chiyoda, Koichi Akashi, Koichiro Kano, Hideyuki Saya
- Organizer
  第14回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県・淡路市）
- Year and Date
  2016-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-16K18426
[Presentation] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation2016
- Author(s)
  信末博行、佐谷秀行
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学国際関係学部三島駅北口校舎（静岡県・三島市）
- Year and Date
  2016-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K18426

1. Saya Hideyuki (80264282)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. 植野さやか (80848937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 川久保博文 (20286496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松田諭 (30594725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIMIZU Takatsune

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 神田輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 有馬好美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nobusue Hiroyuki 信末 博行

NOBUSUE HIROYUKI 信末 博行

Research Projects

Research Products

Co-Researchers

アクチン結合性転写調節因子MKL1活性化を起点とするがん幹細胞薬剤耐性機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of adipocyte-to-cancer-associated fibroblast conversion mechanism and establishment of strategies to control cancer microenvironment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overcoming the drug resistance through drug repositioning in esophageal cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of drug resistance in cancer stem cells regulated by actin cytoskeleton dynamics and therapeutic strategies based on this mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism of cancer-related fibroblast induction and regulation of the tumor microenvironment based on its inhibition

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of master regulators that determine the acquisition of metastatic phenotype in cancer cells and suppression of metastasis based on its controlPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of underlyingmechanism of MKL1-mediated induction of cancer associated fibroblasts and its clinical applications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic strategies for cancer stem cells by regulating cellular differentiation based on actin dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Growth Transformation of B Cells by Epstein-Barr Virus Requires <i>IMPDH2</i> Induction and Nucleolar Hypertrophy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oncogenic KRAS?expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting of cancer stem cells by differentiation therapy2020

Author(s)

Nobusue Hiroyuki 信末博行

NOBUSUE HIROYUKI 信末博行