HAMADA Takashi 濱田恭

Researcher Number	90566978
Other IDs
Affiliation (based on the past Project Information) *help	2017: 名古屋大学, 医学部附属病院, 病院助教 2013: 名古屋大学, 医学(系)研究科(研究院), 寄附講座助教 2013: 名古屋大学, 医学系研究科, 寄附講座助教 2012: 名古屋大学, 大学院・医学系研究科, 助教 2010 – 2012: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Except Principal Investigator Orthopaedic surgery / Surgery related to the biological and sensory functions and related fields
Keywords	Except Principal Investigator microRNA / 軟骨細胞 / 変形性関節症 / 脱分化 / マイクロRNA / 再プログラミング / 細胞・組織 / 後期糖化最終生成物 / 変形性膝関節症 / 加齢 … More / 軟骨代謝 / 関節病学 / miRNA / 変形性関節症(OA) / ADAMTS4 Less

変形性関節症における軟骨細胞の再プログラミングによる多分化能の獲得
- Principal Investigator
  
  酒井忠博
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nagoya University
Micro RNAs could modulate the reprogramming of osteoarthritic chondrocytes.
- Principal Investigator
  
  SAKAI TADAHIRO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
The effect of advanced glycation end products to meniscal degeneration of osteoarthritic knees
- Principal Investigator
  
  HIRAIWA Hideki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
The pathological roles of micro RNAs in osteoarthritis
- Principal Investigator
  
  SAKAI Tadahiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University

All 2013 2012 2011

All Journal Article Presentation

[Journal Article] Chondrogenic capacity and alterations in hyaluronan synthesis of cultured human osteoarthritic chondrocytes.2013
- Author(s)
  Ono Y, Sakai T, Hiraiwa H, Hamada T, Omachi T, Nakashima M, Ishizuka S, Matsukawa T, Knudson W, Knudson CB, Ishiguro N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 435(4) Issue: 4 Pages: 733-739
- DOI
  10.1016/j.bbrc.2013.05.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659672
[Journal Article] SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES2013
- Author(s)
  TAKASHI HAMADA, TADAHIRO SAKAI, HIDEKI HIRAIWA, MOTOSHIGE NAKASHIMA, YOHEI ONO, HIROHITO MITSUYAMA and NAOKI ISHIGURO
- Journal Title
  
  Nagoya J. Med. Sci
  
  Volume: 75 Pages: 101-111
- NAID
  120005227637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659672
[Journal Article] SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES,2013
- Author(s)
  TAKASHI HAMADA, TADAHIRO SAKAI, HIDEKI HIRAIWA, MOTOSHIGE NAKASHIMA, YOHEI ONO, HIROHITO MITSUYAMA and NAOKI ISHIGURO.
- Journal Title
  
  Nagoya J. Med. Sci.
  
  Volume: 75 Pages: 101-111
- NAID
  120005227637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659672
[Journal Article] MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.2013
- Author(s)
  Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 15(1) Issue: 1
- DOI
  10.1186/ar4164
- NAID
  40020134052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659672, KAKENHI-PROJECT-25830062
[Journal Article] Role of S100A12 in the pathogenesis of osteoarthritis2012
- Author(s)
  Motoshige Nakashima
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 422 Issue: 3 Pages: 508-514
- DOI
  10.1016/j.bbrc.2012.05.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659716, KAKENHI-PROJECT-24659672
[Journal Article] Inflammatory effect of advanced glycation end products on human meniseal cells from osteoarthritic knees2011
- Author(s)
  Hiraiwa H, Sakai T, Mitsuyama H, Hamada T, Yamamoto R, Omachi T, Ohno Y, Nakashima M, Ishiguro N
- Journal Title
  
  Inflamm Res
  
  Volume: 60(11) Issue: 11 Pages: 1039-48
- DOI
  10.1007/s00011-011-0365-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390419, KAKENHI-PROJECT-22659269, KAKENHI-PROJECT-23659716
[Presentation] 変形性関節症由来軟骨細胞(OAC)の再分化能についての検討2013
- Author(s)
  小田智之、酒井忠博、平岩秀樹、濱田恭、大野洋平、中島基成、石塚真哉、高松晃、山下暁士、石黒直樹
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  千里ライフサイエンスセンター(豊中市)
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] 変形性関節症由来軟骨細胞の再分化能についての検討2013
- Author(s)
  小田智之、酒井忠博、平岩秀樹、濱田恭、大野洋平、中島基成、石塚真哉、高松晃、山下暁士、石黒直樹
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] MicroRNA-23b suppress MMP-13 expression via post-transcriptional silencing of both hypoxia inducible factor-2αand rund-related transcription factor 2 expression in osteoarthritic chondrocytes2013
- Author(s)
  Shinya Ishizuka, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Tomoyuki Oda, Satoshi Yamashita, Akira Takamatsu, Naoki Ishiguro
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Drug screening for inhibition of Wnt/b-catenin signaling in osteoarthritis2013
- Author(s)
  Akira Takamatsu, Bisei Ohkawara, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Shinya Ishizuka, Tomoyuki Oda, Satoshi Yamashita, Kinji Ohno, Naoki Ishiguro
- Organizer
  2012 Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Antonio（アメリカ）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] 変形性関節症由来軟骨細胞(OAC)の再分化能についての検討2013
- Author(s)
  小田智之、酒井忠博、平岩秀樹、濱田恭、大野洋平、中島基成、石塚真哉、高松晃、山下暁士、石黒直樹
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  千里ライフサイエンスセンター（豊中市）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Successful Phenotype Rescue of Monolayer-expanded Osteoarthritic Human Chondrocytes using Pellet Culture2013
- Author(s)
  Yohei Ono,Tadahiro Sakai, Hedeki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Shinya Ishizuka, Warren Knudson, Cheryl B. Knudson, Naoki Ishiguro
- Organizer
  2013 Annual meeting of AAOS
- Place of Presentation
  シカゴ（アメリカ）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Wntシグナル経路の制御を介した変形性関節症に対する新たな治療薬の検索2013
- Author(s)
  高松晃、酒井忠博、平岩秀樹、濱田恭、中島基成、松川哲也、小田智之、山下暁士、宮本健太郎、石黒直樹、大河原美静、大野欽司
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Wntシグナル経路の制御を介した変形性関節症に対する新たな治療薬の検索2013
- Author(s)
  高松晃、酒井忠博、平岩秀樹、濱田恭、中島基成、松川哲也、小田智之、山下暁士、宮本健太郎、石黒直樹、大河原美静、大野欽司
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ(千葉市)
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Drug screening for inhibition of Wnt/β-catenin signaling in osteoarthritis2013
- Author(s)
  Akira Takamatsu, Bisei Ohkawara, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Shinya Ishizuka, Tomoyuki Oda, Satoshi Yamashita, Kinji Ohno, Naoki Ishiguro
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] MicroRNA-23b suppress MMP-13 expression via post-transcriptional silencing of both hypoxia inducible factor-2α and rund-related transcription factor 2 expression in osteoarthritic chondrocytes2013
- Author(s)
  Ishizuka,S; Sakai, T; Hiraiwa, H; Hamada, T; Nakashima, M; Oda T; Takamatsu A; Yamashita S; Ishiguro, N
- Organizer
  2012 Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Antonio（アメリカ）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] 変形性関節症由来軟骨細胞の再分化能についての検討2013
- Author(s)
  小田智之、酒井忠博、平岩秀樹、濱田恭、大野洋平、中島基成、石塚真哉、高松晃、山下暁士、石黒直樹
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ(千葉市)
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] MicroRNA-23b and 27b regulate both Hypoxia-inducible factor-2a and endochondral ossification related gene expressions in osteoarthritic chondrocytes2012
- Author(s)
  Shinya Ishizuka, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Ohmachi, Yohei Ohno, Motoshige Nakashima, Tetsuya Matsukawa, et al.
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  Spotlight Session
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-22659271
[Presentation] 変形性関節症(OA)半月板細胞におけるhypoxiainducible factor-2α(HIF-2α)の高発現と軟骨内骨化関連遺伝子の制御2012
- Author(s)
  石塚真哉、酒井忠博、平岩秀樹、濱田恭、中島基成、小田智之、高松晃、山下暁士、石黒直樹
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] 他人OA軟骨細胞におけるmicroRNA-125bによるAggrecanase-1(ADAMTS4)の発現制御2012
- Author(s)
  松川哲也、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基茂
- Organizer
  第25回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22659271
[Presentation] 他microRNA-23b, 27bはOAの軟骨細胞においてHypoxia-inducible factor-2a(HIF-2a)及び軟骨内骨化関連遺伝子の発現を制御する2012
- Author(s)
  石塚真哉、酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基茂
- Organizer
  第25回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22659271
[Presentation] The effect of S100A12 in the pathogenesis of osteoarthritis2012
- Author(s)
  Nakashima M, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, et al
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  San Francisco, California, USA
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] OA半月板におけるHIF-2αの高発現2012
- Author(s)
  石塚真哉, 酒井忠博, 平岩秀樹, 濱田恭ら
- Organizer
  第40回日本関節病学会
- Place of Presentation
  鹿児島
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] MicroRNA-125b regulates the expression of Aggrecanase-1(ADAMTS4) in human osteoarthritic chondrocytes2012
- Author(s)
  Tetsuya Matsukawa, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Ohmachi, Yohei Ohno, Motoshige Nakashima, Shinya Ishizuka, et al.
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  Spotlight Session
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-22659271
[Presentation] MicroRNA-125b Regulates the Expression of Aggrecanase-1 (ADAMTS4) in Human Osteoarthritic Chondrocytes2012
- Author(s)
  Tetsuya Matsukawa, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Omachi, Motoshige Nakashima, Shinya Ishizuka, Tomoyuki Oda, Akira Takamatsu, Satoshi Yamashita, Naoki Ishiguro
- Organizer
  10th World Congress of the International Cartilage Repair Society　2012
- Place of Presentation
  モントリオール（カナダ）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] microRNA-23bはHIF2-α、RUNX2の発現抑制を介してOA軟骨細胞におけるMMP-13の発現を制御する。2012
- Author(s)
  石塚真哉、酒井忠博、平岩秀樹、濱田恭、中島基成、小田智之、高松晃、山下暁士、石黒直樹
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Increased expression of Hypoxia-inducible factor-2α in osteoarthritic meniscus cells2012
- Author(s)
  Ishizuka,S; Sakai, T; Hiraiwa, H; Hamada, T;Nakashima, M; Oda T; Takamatsu A; YamashitaS; Ishiguro, N
- Organizer
  第40回日本関節病学会
- Place of Presentation
  鹿児島市民文化ホール、鹿児島サンロイヤルホテル（鹿児島
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] Increased expression of Hypoxia-inducible factor-2α in osteoarthritic meniscus cells2012
- Author(s)
  Ishizuka,S; Sakai, T; Hiraiwa, H; Hamada, T; Nakashima, M; Oda T; Takamatsu A; Yamashita S; Ishiguro, N
- Organizer
  第40回日本関節病学会
- Place of Presentation
  鹿児島市民文化ホール、鹿児島サンロイヤルホテル（鹿児島市）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] S100A12タンパクによる変形性関節症の進行における影響2012
- Author(s)
  中島基成, 酒井忠博, 平岩秀樹, 濱田恭ら
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] S100A12タンパクによる変形性関節症の進行における影響2012
- Author(s)
  中島基成、酒井忠博、平岩秀樹、濱田恭、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] 変形性関節症(OA)半月板細胞におけるhypoxiainducible factor-2α(HIF-2α)の高発現と軟骨内骨化関連遺伝子の制御2012
- Author(s)
  石塚真哉, 酒井忠博, 平岩秀樹, 濱田恭ら
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] OA半月板におけるHypoxia-inducible factor-2α の高発現2012
- Author(s)
  石塚真哉、酒井忠博、平岩秀樹、濱田恭、中島基成、小田智之、高松晃、山下暁士、石黒直樹
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] S100A12タンパクによる変形性関節症の進行における影響2012
- Author(s)
  中島基成、酒井忠博、平岩秀樹、濱田恭、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] microRNA-23bはHIF2-α、RUNX2の発現抑制を介してOA軟骨細胞におけるMMP-13の発現を制御する2012
- Author(s)
  石塚真哉、酒井忠博、平岩秀樹、濱田恭、中島基茂、小田智之、高松晃、山下暁士、石黒直樹
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Data Source
  KAKENHI-PROJECT-24659672
[Presentation] Increased expression of Hypoxia-inducible factor-2alfa in osteoarthritic meniscus cells2012
- Author(s)
  Ishizuka S, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, et al
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  San Francisco, California, USA
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-23659716
[Presentation] 単層培養過程の継代に伴うヒトOA軟骨細胞の表現型変化と再分化能2011
- Author(s)
  大野洋平、酒井忠博、平岩秀樹、濱田恭、山本隆一郎、大間知孝顕、中島基成、犬飼規夫、石塚真哉、松川哲也、石黒直樹
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  九州大学百年講堂(福岡市)
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-22659271
[Presentation] 膝蓋靭帯欠損部再生組織における腱関連遺伝子と軟骨関連遺伝子の発現2011
- Author(s)
  大間知孝顕、酒井忠博、平岩秀樹、濱田恭、山本隆一郎、中島基成、大野洋平、犬飼規夫、松川哲也、石塚真哉、石黒直樹
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  九州大学百年講堂(福岡市)
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-22659271

1. SAKAI Tadahiro (60378198)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
2. HIRAIWA Hideki (70566976)

# of Collaborated Projects: 4 results

# of Collaborated Products: 35 results
3. YAMAMOTO Ryuichiro (80586743)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 光山浩人 (80467282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 宮本健太郎 (50789899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大野洋平 (60792736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHMACHI Takaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 石黒直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAMADA Takashi 濱田 恭

Research Projects

Research Products

Co-Researchers

変形性関節症における軟骨細胞の再プログラミングによる多分化能の獲得

Principal Investigator

Project Period (FY)

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Research Institution

Micro RNAs could modulate the reprogramming of osteoarthritic chondrocytes.

Principal Investigator

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Research Institution

The effect of advanced glycation end products to meniscal degeneration of osteoarthritic knees

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pathological roles of micro RNAs in osteoarthritis

Principal Investigator

Project Period (FY)

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[Journal Article] Chondrogenic capacity and alterations in hyaluronan synthesis of cultured human osteoarthritic chondrocytes.2013

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DOI

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[Journal Article] SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES2013

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NAID

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[Journal Article] SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES,2013

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NAID

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[Journal Article] MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.2013

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DOI

NAID

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[Journal Article] Role of S100A12 in the pathogenesis of osteoarthritis2012

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DOI

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[Journal Article] Inflammatory effect of advanced glycation end products on human meniseal cells from osteoarthritic knees2011

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DOI

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[Presentation] 変形性関節症由来軟骨細胞(OAC)の再分化能についての検討2013

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Organizer

Place of Presentation

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[Presentation] 変形性関節症由来軟骨細胞の再分化能についての検討2013

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[Presentation] MicroRNA-23b suppress MMP-13 expression via post-transcriptional silencing of both hypoxia inducible factor-2αand rund-related transcription factor 2 expression in osteoarthritic chondrocytes2013

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[Presentation] Drug screening for inhibition of Wnt/b-catenin signaling in osteoarthritis2013

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[Presentation] 変形性関節症由来軟骨細胞(OAC)の再分化能についての検討2013

HAMADA Takashi 濱田恭