Hashimoto Kae 橋本香映

… Alternative Names

HASHIMOTO Kae 橋本香映

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Researcher Number	90612078
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, 大学院医学系研究科, 講師 2020 – 2022: 大阪大学, 医学部附属病院, 特任准教授(常勤) 2016 – 2020: 大阪大学, 医学系研究科, 助教 2011 – 2016: 大阪大学, 医学(系)研究科(研究院), 助教 2011 – 2014: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 子宮内膜症 / 糖鎖 / エクソソーム / レクチン / 子宮内膜間質細胞 / 接着 / 接着因子 / SDF-1 / 腹膜播種 / 卵巣癌 … More Except Principal Investigator … More 卵巣癌 / 卵巣がん / マイクロRNA / 腹膜播種 / Sleeping beautyトランスポゾン / 子宮平滑筋肉腫 / 治療抵抗性 / MDSC / エクソソーム / バイオマーカー / 低酸素刺激 / 耐性化 / 遺伝子改変モデルマウス / CRISPR-Cas9c / GWAS / CRISPR-Cas9 / GEMM / マウスモデル / HGSC / MAVS / type-1 IFN / Aurora kinase / 漿液性卵巣癌 / PDX / 3次元培養 / ドラッグスクリーニング / ARID1A / 子宮体がん / 婦人科がん / 発生 / フォワードジェネティクス / 薬剤抵抗性 / 増悪 / 発症 / トランスポゾンスクリーニング / Sleeping beauty / miR-1290 / miR-99a-5p / DDS / ドライバー遺伝子 / フォワードジェネティックスクリーニング / スクリーニング / トランスポゾン / 耐性機構 / 免疫療法 / 免疫寛容 / 抗腫瘍免疫 / PGE2 / PD-L1 / 免疫逃避 / 癌幹細胞 / 転移・浸潤 / Bevacizumab耐性化 / 前転移ニッチ / Bevacizumab / 耐性 / 血管新生阻害薬 / パクリタキセル耐性 / CD44 miR-99a / paclitaxel / exosome / microRNA / peritoneal dissemination / Ovarian cancer / PlGF / NF-κBシグナル / 分子標的治療 / 抗血管新生治療 / VEGF / NF-κB シグナル / 抗血管新生療法 / Eカドヘリン / 脱落膜細胞 / 絨毛細胞 / 絨毛羊膜炎 / プロスタグランジン / インターロイキン / 前期破水 / 常位胎盤早期剥離 / 骨髄由来細胞 / 腹膜中皮細胞 / everolimus / 卵巣明細胞腺癌 / 明細胞腺癌 / 耐性化機構 / Trabectedin / mTORC1阻害薬 / mTORC1 / mTORC2 Less

Aurora Kinase を標的とした、卵巣癌の免疫療法抵抗性解除の可能性の探索
- Principal Investigator
  
  中塚えりか
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
CRISPR-Cas9によるスピーディかつ汎用性の高い卵巣がんモデルマウスの樹立
- Principal Investigator
  
  中村幸司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
エクソソーム表面糖鎖を標的とした新規子宮内膜症バイオマーカーの開発Principal Investigator
- Principal Investigator
  
  橋本香映
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
PDXとドラッグスクリーニングによるARID1A変異婦人科がんの個別化医療開発
- Principal Investigator
  
  木瀬康人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
低酸素環境下におけるMDSCの癌幹細胞誘導作用の解明
- Principal Investigator
  
  松本有里
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
Investigation of sarcomagenesis and progression mechanisms in uterine leiomyosarcoma by transposon screening method
- Principal Investigator
  
  Kodama Michiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
The role of lectins in the development of endometriosis.Principal Investigator
- Principal Investigator
  
  Hashimoto Kae
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
The development of a novel microRNA replacement therapy for ovarian cancer - a potential of patient derived-exosomes as a carrier.
- Principal Investigator
  
  Sawada Kenjiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
The mechanism of immune escape by myeloid-derived suppressor cells and cancer stem cells in ovarian cancer.
- Principal Investigator
  
  Mabuchi Seiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nara Medical University
  Osaka University
Sleeping Beauty Transposon mutagenesis screen for identifying driver genes in uterine leiomyosarcoma
- Principal Investigator
  
  Kodama Michiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Pathogenesis of endometriosis via endometrial stromal cell derived exosomes.Principal Investigator
- Principal Investigator
  
  Hashimoto Kae
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Why is the treatment of peritoneal dissemination so difficult? Analyses focusing on microRNA and exosome.
- Principal Investigator
  
  Sawada Kenjiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Role of MDSC-mediated premetastatic niche formation in the resistance of Anti-angiogenic agent.
- Principal Investigator
  
  Mabuchi Seiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Investigate the adhesion molecules that control the progression of endometriosis.Principal Investigator
- Principal Investigator
  
  Hashimoto Kae
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Devoleping a novel anti-angiogenic therapy focused on placental growth factor secreted by ovarian cancer cells
- Principal Investigator
  
  SAKATA Masahiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Potential role of mTORC2 as a therapeutic target in epithelial ovarian cancer
- Principal Investigator
  
  MABUCHI Seiji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Identification of micro RNAs which affected by tumor microenvironments of ovarian cancer and analysis of a potential as a therapeutic target
- Principal Investigator
  
  SAWADA Kenjiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
The molecular analysis of placental abruption using in vitro placental model
- Principal Investigator
  
  KIMURA Tadashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Analysis of the host factor which is important for ovarian cancer disseminationPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Kae
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Gastric-Type Adenocarcinoma of the Uterine Cervix Associated with Poor Response to Definitive Radiotherapy2022
- Author(s)
  Kuruma Airi、Kodama Michiko、Hori Yumiko、Sato Kazuaki、Fujii Makoto、Isohashi Fumiaki、Miyoshi Ai、Mabuchi Seiji、Setoguchi Akira、Shimura Hiroko、Goto Takeshi、Toda Aska、Nakagawa Satoshi、Kinose Yasuto、Takiuchi Tsuyoshi、Kobayashi Eiji、Hashimoto Kae、Ueda Yutaka、Sawada Kenjiro、Morii Eiichi、Kimura Tadashi
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 1 Pages: 170-170
- DOI
  10.3390/cancers15010170
- Data Source
  KAKENHI-PROJECT-20K09617
[Journal Article] Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma2021
- Author(s)
  Kodama Michiko、Shimura Hiroko、Tien Jean C.、Newberg Justin Y.、Kodama Takahiro、Wei Zhubo、Rangel Roberto、Yoshihara Kosuke、Kuruma Airi、Nakae Aya、Hashimoto Kae、Sawada Kenjiro、Kimura Tadashi、Jenkins Nancy A.、Copeland Neal G.
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 21 Pages: 5413-5424
- DOI
  10.1158/0008-5472.can-21-0356
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K09617, KAKENHI-PROJECT-16H06279
[Journal Article] Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer2020
- Author(s)
  Kobayashi Masaki、Sawada Kenjiro、Miyamoto Mayuko、Shimizu Aasa、Yamamoto Misa、Kinose Yasuto、Nakamura Koji、Kawano Mahiru、Kodama Michiko、Hashimoto Kae、Kimura Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 527 Issue: 1 Pages: 153-161
- DOI
  10.1016/j.bbrc.2020.04.076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09227
[Journal Article] The role of myeloid-derived suppressor cells in endometrial cancer displaying systemic inflammatory response: clinical and preclinical investigations.2020
- Author(s)
  4.Yokoi E, Mabuchi S, Komura N, Shimura K, Kuroda H, Kozasa K, Takahashi R, Sasano T, Kawano M, Matsumoto Y, Kodama M, Hashimoto K, Sawada K, Kimura T.
- Journal Title
  
  Oncoimmunology.
  
  Volume: 8 Issue: 12 Pages: e1662708-e1662708
- DOI
  10.1080/2162402x.2019.1662708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11276
[Journal Article] Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells2018
- Author(s)
  Yoshimura Akihiko、Sawada Kenjiro、Nakamura Koji、Kinose Yasuto、Nakatsuka Erika、Kobayashi Masaki、Miyamoto Mayuko、Ishida Kyoso、Matsumoto Yuri、Kodama Michiko、Hashimoto Kae、Mabuchi Seiji、Kimura Tadashi
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 1065-1065
- DOI
  10.1186/s12885-018-4974-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09227
[Journal Article] Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types2018
- Author(s)
  Kobayashi Masaki、Sawada Kenjiro、Nakamura Koji、Yoshimura Akihiko、Miyamoto Mayuko、Shimizu Aasa、Ishida Kyoso、Nakatsuka Erika、Kodama Michiko、Hashimoto Kae、Mabuchi Seiji、Kimura Tadashi
- Journal Title
  
  Journal of Ovarian Research
  
  Volume: 11 Issue: 1 Pages: 81-81
- DOI
  10.1186/s13048-018-0458-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09227
[Journal Article] The Highly Metastatic Nature of Uterine Cervical/Endometrial Cancer Displaying Tumor-Related Leukocytosis: Clinical and Preclinical Investigations2018
- Author(s)
  Sasano Tomoyuki、Mabuchi Seiji、Kozasa Katsumi、Kuroda Hiromasa、Kawano Mahiru、Takahashi Ryoko、Komura Naoko、Yokoi Eriko、Matsumoto Yuri、Hashimoto Kae、Sawada Kenjiro、Morii Eiichi、Kimura Tadashi
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 24 Issue: 16 Pages: 4018-4029
- DOI
  10.1158/1078-0432.ccr-17-2472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11276
[Journal Article] Prostaglandin E2 produced by myeloid-derived suppressive cells induces cancer stem cells in uterine cervical cancer2018
- Author(s)
  Kuroda Hiromasa、Mabuchi Seiji、Yokoi Eriko、Komura Naoko、Kozasa Katsumi、Matsumoto Yuri、Kawano Mahiru、Takahashi Ryoko、Sasano Tomoyuki、Shimura Kotaro、Kodama Michiko、Hashimoto Kae、Sawada Kenjiro、Morii Eiichi、Kimura Tadashi
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 91 Pages: 36317-36330
- DOI
  10.18632/oncotarget.26347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11276
[Journal Article] Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer2018
- Author(s)
  Yokoi Eriko、Mabuchi Seiji、Shimura Kotaro、Komura Naoko、Kozasa Katsumi、Kuroda Hiromasa、Takahashi Ryoko、Sasano Tomoyuki、Kawano Mahiru、Matsumoto Yuri、Kodama Michiko、Hashimoto Kae、Sawada Kenjiro、Kimura Tadashi
- Journal Title
  
  Investigational New Drugs
  
  Volume: － Issue: 5 Pages: 818-827
- DOI
  10.1007/s10637-018-0686-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11276
[Journal Article] Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.2017
- Author(s)
  Nakamura, K. Sawada, K. Kinose, Y. Yoshimura, A. Toda, A. Nakatsuka, E. Hashimoto, K. Mabuchi, S. Morishige, KI. Kurachi, H. Lengyel, E. Kimura, T.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 15(1) Issue: 1 Pages: 78-92
- DOI
  10.1158/1541-7786.mcr-16-0191
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293360, KAKENHI-PROJECT-26670725
[Journal Article] PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo2017
- Author(s)
  Kuroda Hiromasa、Mabuchi Seiji、Kozasa Katsumi、Yokoi Eriko、Matsumoto Yuri、Komura Naoko、Kawano Mahiru、Hashimoto Kae、Sawada Kenjiro、Kimura Tadashi
- Journal Title
  
  Immunotherapy
  
  Volume: 9 Issue: 10 Pages: 805-817
- DOI
  10.2217/imt-2017-0046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11276, KAKENHI-PROJECT-15H02564
[Journal Article] The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft ModelMice.2016
- Author(s)
  Sawada, I. Hashimoto, K. Sawada, K. Kinose, Y. Nakamura, K. Toda, A. Nakatsuka, E. Yoshimura, A. Mabuchi, S. Fujikawa, T. Itai, A. Kimura, T.
- Journal Title
  
  Int J Gynecol Cancer
  
  Volume: 26(4) Issue: 4 Pages: 610-618
- DOI
  10.1097/igc.0000000000000668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293360, KAKENHI-PROJECT-26670725
[Journal Article] Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary.2016
- Author(s)
  Takahashi R, Mabuchi S, Kawano M, Sasano T, Matsumoto Y, Kuroda H, Kozasa K, Hashimoto K, Sawada K, Kimura T.
- Journal Title
  
  PLoS One
  
  Volume: 17;11(3) Issue: 3 Pages: e0151050-e0151050
- DOI
  10.1371/journal.pone.0151050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02564, KAKENHI-PROJECT-26462523
[Journal Article] Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells.2016
- Author(s)
  Toda, A. Sawada, K. Fujikawa, T. Wakabayashi, A. Nakamura, K. Sawada, I. Yoshimura, A. Nakatsuka, E. Kinose, Y. Hashimoto, K. Mabuchi, S. Tokuhira, A. Nakayama, M. Itai, A. Kurachi, H. Kimura, T.
- Journal Title
  
  Am J Pathol
  
  Volume: 186(3) Pages: 616-629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293360
[Journal Article] The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma2015
- Author(s)
  Kinose, Y. Sawada, K. Nakamura, K. Sawada, I. Toda, A. Nakatsuka, E. Hashimoto, K. Mabuchi, S. Takahashi, K. Kurachi, H. Lengyel, E. Kimura, T.
- Journal Title
  
  Oncotarget
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592515
[Journal Article] The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma2015
- Author(s)
  Kinose, Y. Sawada, K. Nakamura, K. Sawada, I. Toda, A. Nakatsuka, E. Hashimoto, K. Mabuchi, S. Takahashi, K. Kurachi, H. Lengyel, E. Kimura, T.
- Journal Title
  
  Oncotarget
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293360
[Journal Article] IKKβ Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Anti-angiogenic Treatment2015
- Author(s)
  Kinose, Y. Sawada, K. Makino, H. Ogura, T. Mizuno, T. Suzuki, N. Fujikawa, T. Morii, E. Nakamura, K. Sawada, I. Toda, A. Hashimoto, K. Isobe, A. Mabuchi, S. Ohta, T. Itai, A. Morishige, K. I. Kurachi, H. Kimura, T
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 14 Issue: 4 Pages: 909-19
- DOI
  10.1158/1535-7163.mct-14-0696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592515, KAKENHI-PROJECT-26293360, KAKENHI-PROJECT-26462519, KAKENHI-PROJECT-26670725
[Journal Article] The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer.2015
- Author(s)
  Kawano M, Mabuchi S, Matsumoto Y, Sasano T, Takahashi R, Kuroda H, Kozasa K, Hashimoto K, Isobe A, Sawada K, Hamasaki T, Morii E, Kimura T.
- Journal Title
  
  Scientific Reports
  
  Volume: 15;5 Issue: 1 Pages: 18217-18217
- DOI
  10.1038/srep18217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462523, KAKENHI-PROJECT-15H02564
[Journal Article] Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer.2015
- Author(s)
  Isobe A, Sawada K, Kinose Y, Ohyagi-Hara C, Nakatsuka E, Makino H, Ogura T, Mizuno T, Suzuki N, Morii E, Nakamura K, Sawada I, Toda A, Hashimoto K, Mabuchi S, Ohta T, Morishige K, Kurachi H, Kimura T.
- Journal Title
  
  PloS One
  
  Volume: 10 Issue: 2 Pages: e0118080-e0118080
- DOI
  10.1371/journal.pone.0118080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293360
[Journal Article] miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression2013
- Author(s)
  Ohyagi-Hara C, Sawada K, Mabuchi S, Takahashi T, Kurachi H
- Journal Title
  
  Am J Pathol
  
  Volume: 182(5) Issue: 5 Pages: 1876-1889
- DOI
  10.1016/j.ajpath.2013.01.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-23592443, KAKENHI-PROJECT-23592447, KAKENHI-PROJECT-23890102, KAKENHI-PROJECT-24249080, KAKENHI-PROJECT-24590459, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-25293342, KAKENHI-PROJECT-25462588
[Journal Article] miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin alpha5 Expression2013
- Author(s)
  Ohyagi-Hara, C. Sawada, K. Kamiura, S. Tomita, Y. Isobe, A. Hashimoto, K. Kinose, Y. Mabuchi, S. Hisamatsu, T. Takahashi, T. Kumasawa, K. Nagata, S. Morishige, K. I. Lengyel, E. Kurachi, H. Kimura, T.
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Pages: 1876-1889
- Data Source
  KAKENHI-PROJECT-23592447
[Journal Article] Low-dose metronomic oral dosing of a prodrug of Gemcitabine (LY2334737) causes anti-tumor effects in the absence of inhibition of systemic vasculogenesis.2012
- Author(s)
  Francia G, Shaked Y, Hashimoto K, Sun J, Yin M, Cesta C, Xu P, Man S, Hackl C, Stewart J, Uhlik M, Dantzig A. H, Foster S, Kerbel R. S.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11 Pages: 680-689
- Data Source
  KAKENHI-PROJECT-23890100
[Presentation] Excellent Usefulness of Engineered Exosomes as a Carrier for Tumor-suppressor microRNA Replacement Therapy of Ovarian Cancer2021
- Author(s)
  kobayashi, M. Sawada, K. Miyamoto, M. Shimizu, A. Yamamoto, M. Kawano, M. Kodama, M. Hashimoto, K. Kimura, T.
- Organizer
  第62回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] Screening of cancer driver genes involved in sarcomagenesis and metastasis of uterine leiomyosarcoma using Sleeping Beauty transposon2020
- Author(s)
  Hiroko Shimura, Michiko Kodama, Kosuke Yoshihara, Aya Nakae, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura
- Organizer
  第72回日本産科婦人科学術講演会
- Data Source
  KAKENHI-PROJECT-20K09617
[Presentation] The potential of engineered exosomes as a carrier of tumor-suppressor microRNA replacement therapy for ovarian cancer2020
- Author(s)
  Kobayashi, M. Sawada, K. Miyamoto, M. Shimizu, A. Yamamoto, M. Kawano, M. Kodama, M. Hashimoto, K. Kimura, T.
- Organizer
  第72回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] Potential of patient-derived exosomes as a carrier of siRNA delivery for the treatment of ovarian cancer peritoneal dissemination2020
- Author(s)
  Shimizu, A. Sawada, K. Kobayashi, M. Miyamoto, M. Kinose, Y. Kodama, M. Hashimoto, K. Kimura, T.
- Organizer
  第72回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-18K09227
[Presentation] Sleeping beauty transposon mutagenesis screen identified cancer genes driving sarcomagenesis and metastases of uterine leiomyosarcoma2019
- Author(s)
  小玉美智子　中江彩　吉原弘祐　橋本香映　澤田健二郎　木村正
- Organizer
  第61回日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Myeloid derived suppressor cells (MDSC) increase the stem cell properties and tumor PD-L1 expression of ovarian cancer.2018
- Author(s)
  Komura N, Mabuchi S, Shimura K, Yokoi E, Kawano M, Matsumoto Y, Kodama M, Hashimoto K, Sawada K, Kimura T.
- Organizer
  The 17th Biennial Meeting of the International Gynecologic Cancer Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11276
[Presentation] Sleeping beauty transposon insertional mutagenesis identified driver genes of uterine leiomyosarcoma.2018
- Author(s)
  Michiko Kodama, Hiroko Shimura, Aya Nakae, Kae Hashimoto, Seiji Mabuchi, Kenjiro Sawada, Tadashi Kimura.
- Organizer
  The 17th Biennial Meeting of the International Gynecologic Cancer Society (International Gynecologic Cancer Society)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] トランスポゾンを用いたマウス子宮平滑筋肉腫発症に関与するドライバー遺伝子のスクリーニング2018
- Author(s)
  小玉美智子　中江彩　志村寛子　橋本香映　馬淵誠士　澤田健二郎　木村正
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Sleeping Beauty transposon mutagenesis screen identifies cancer genes of uterine leiomyosarcoma driving sarcomagenesis and lung metastasis.2018
- Author(s)
  Michiko Kodama, Takahiro Kodama, Justin Y. Newberg, Jean C. Tien, Roberto Rangel, Aya Nakae, Kae Hashimoto, Seiji Mabuchi, Kenjiro Sawada, Tadashi Kimura, Nancy A. Jenkins, Neal G. Copeland.
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11277
[Presentation] Expression pattern of membrane proteins in endometrial stromal cells from women with endometriosis2018
- Author(s)
  Yamashita, S. Hashimoto, K. Yoshimura, A. Sawada, I. Matsumoto, Y. Kodama, M. Mabuchi, S. Sawada, K. Kimura, T.
- Organizer
  第70回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K11138
[Presentation] 婦人科癌治療に伴う骨粗鬆症に対するデノスマブの有用性の検討2016
- Author(s)
  中塚えりか　澤田健二郎　木瀬康人　吉村明彦　黒田浩正小笹勝巳　小玉美智子　橋本香映　中村幸司　馬淵誠士　木村正
- Organizer
  第135回近畿産婦人科学会
- Place of Presentation
  京都
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-26293360
[Presentation] 卵巣癌細胞由来exosome の腹膜中皮細胞への情報伝達機構の解明―癌細胞由来CD44 はexosome により中皮細胞に移行し，腹膜中皮のMMP 9 分泌促進，Ecadherin 発現抑制を誘導し腹膜播種を促進する2015
- Author(s)
  中村幸司　澤田健二郎　木瀬康人　吉村明彦　中塚えりか　戸田有朱香　橋本香映　馬淵誠士　木村正
- Organizer
  第6７回日本産科婦人科学会学術講演会
- Place of Presentation
  横浜
- Year and Date
  2015-04-09
- Data Source
  KAKENHI-PROJECT-26293360
[Presentation] 子宮内膜症病変形成におけるVCAM-1の関与の検討2015
- Author(s)
  澤田育子　橋本香映　中村幸司　戸田有朱香　中塚えりか　木瀬康人　澤田健二郎
- Organizer
  第6７回日本産科婦人科学会学術講演会
- Place of Presentation
  横浜
- Year and Date
  2015-04-09
- Data Source
  KAKENHI-PROJECT-25462592
[Presentation] 子宮内膜症に対する新規低分子IKK阻害剤(IMD-0560)の効果の検討2014
- Author(s)
  澤田育子　橋本香映　木瀬康人　戸田有朱香　中村幸司　澤田健二郎　木村　正
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25462592
[Presentation] The significance of vascular endothelial growth factor C in the lymphangiogenesis and lymph node metastasis of ovarian cancer2013
- Author(s)
  Hisamatsu, T. Mabuchi, S. Sasano, T. Takahashi, R. Kawano, M. Matsumoto, Y. Hashimoto, K. Isobe, A. Sawada, K. Sakata, M. Kimura, T.
- Organizer
  The 104th Annual Meeting American Association for Cancer Research
- Place of Presentation
  Washington DC, U.S.A
- Data Source
  KAKENHI-PROJECT-23592446
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659779
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23592447
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志, 馬淵誠士, 河野まひる, 橋本香映, 磯部晶, 澤田健二郎, 木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-23890100
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23592446
[Presentation] 卵巣癌癌性腹膜炎モデルにおける新規低分子 IKK 阻害剤(IMD-0540)の有効性の検討2012
- Author(s)
  橋本香映, 澤田健二郎, 磯部晶, 大八木知史, 木瀬康人, 馬淵誠士, 木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-23890100
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592447
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23659779
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592446
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 卵巣癌組織における Integrin α5 の発現が予後に与える影響の解析2012
- Author(s)
  大八木知史, 澤田健二郎, 木瀬康人, 橋本香映, 馬淵誠士, 上浦祥司, 木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-23890100
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 上皮性卵巣癌における mTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志, 馬淵誠士, 河野まひる, 橋本香映, 磯部晶, 澤田健二郎, 木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-23890100
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23890100
[Presentation] 絨毛膜炎羊膜炎胎盤におけるIL-6産生細胞の同定とそれを標的とした早産治療
- Author(s)
  戸田有朱香. 澤田健二郎. 藤川智行. 橋本香映. 澤田育子. 木瀬康人. 板井昭子. 木村　正
- Organizer
  第22回胎盤学会
- Place of Presentation
  京都
- Year and Date
  2014-10-03 – 2014-10-04
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 卵巣癌においてmiR-194はBMI-1を制御することでパクリタキセル耐性を減弱させる
- Author(s)
  中村幸司. 澤田健二郎. 木瀬康人. 橋本香映. 木村　正
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293360
[Presentation] 絨毛膜羊膜炎胎盤におけるInterleukin-6(IL-6)産生細胞の同定とそれを標的とした早産治療の可能性の検討
- Author(s)
  戸田有朱香. 澤田健二郎. 橋本香映. 澤田育子. 磯部　晶. 木瀬康人. 坂田正博. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 低酸素環境下で発現が変動する microRNA の網羅的解析を通じた卵巣癌腹膜播種抑制の分子標的治療の可能性-低酸素刺激で発現低下を示すmiR-199a-3pはc-Metの発現抑制を通じて播種進展を抑制する
- Author(s)
  木瀬康人. 澤田健二郎. 中村幸司. 牧野　弘. 水野智子. 橋本香映. 磯部　晶. 馬淵誠士. 坂田正博. 森重健一郎. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 子宮内膜症に対する新規低分子IKK阻害剤（IMD-0560）の効果の検討
- Author(s)
  澤田育子橋本香映澤田健二郎木村正
- Organizer
  第24回近畿エンドメトリオーシス研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25462592
[Presentation] Targeting inhibitor of NF-κb kinase beta (IKKβ) may represent a possible novel treatment for endometriosis
- Author(s)
  Sawada, I. Hashimoto, K. Sawada, K. Fujikawa, T. Itai, A. Kimura, T.
- Organizer
  Endocrine Society’s 96th Annual Meeting and Expo
- Place of Presentation
  Chicago, U.S.A
- Year and Date
  2014-06-21 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 子宮内膜症に対する新規低分子IKK阻害剤(IMD-0560)の効果の検討
- Author(s)
  澤田育子. 橋本香映. 木瀬康人. 戸田有朱香. 中村幸司. 澤田健二郎. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] Targeting IKKβ signaling prevents preterm delivery through the inhibition of interleukin-6 (IL-6)production from amniotic mesenchymal stromal cells
- Author(s)
  Toda, A. Sawada, K. Kinose, Y. Hashimoto, K. Fujikawa, T. Itai, A. Kimura, T.
- Organizer
  Endocrine Society’s 96th Annual Meeting and Expo
- Place of Presentation
  Chicago, U.S.A
- Year and Date
  2014-06-21 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 低酸素環境下で発現が変動する microRNA の網羅的解析を通じた卵巣癌腹膜播種抑制の分子標的治療の可能性-低酸素刺激で発現低下を示すmiR-199a-3pはc-Metの発現抑制を通じて播種進展を抑制する
- Author(s)
  木瀬康人. 澤田健二郎. 中村幸司. 牧野　弘. 水野智子. 橋本香映. 磯部　晶. 馬淵誠士. 坂田正博. 森重健一郎. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-26293360
[Presentation] Identification of microRNA which regulates paclitaxel resistance of ovarian cancer cells - a potential of miR-194 by attenuating paclitaxel resistance through the down-regulation of oncogene BMI-1
- Author(s)
  Nakamura, K. Sawada, K. Kinose, Y. Hashimoto, K. Mabuchi, S. Kimura, T.
- Organizer
  105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, U.S.A.
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-26293360
[]

1. SAWADA Kenjiro (00452392)

# of Collaborated Projects: 17 results

# of Collaborated Products: 52 results
2. MABUCHI Seiji (00452441)

# of Collaborated Projects: 11 results

# of Collaborated Products: 37 results
3. Kodama Michiko (70791391)

# of Collaborated Projects: 8 results

# of Collaborated Products: 12 results
4. SOBE I Aki (60397619)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
5. 松本有里 (90756488)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. 木瀬康人 (90778531)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
7. 中村幸司 (00900151)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
8. KIMURA Tadashi (90240845)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
9. 山下紗弥 (40880993)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. SAKATA Masahiro (10260639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 中塚えりか (00816514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 戸田有朱香 (00884610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岡村綾子 (40910253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Yoshimura Akihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. Kawano Mahiru

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. Takahashi Ryoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. Kuroda Hiromasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. Kozasa Katsumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. Yokoi Eriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Sasano Tomoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小玉尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 高橋俊文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 倉智博久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Kae 橋本 香映

HASHIMOTO Kae 橋本 香映

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エクソソーム表面糖鎖を標的とした新規子宮内膜症バイオマーカーの開発Principal Investigator

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The role of lectins in the development of endometriosis.Principal Investigator

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Pathogenesis of endometriosis via endometrial stromal cell derived exosomes.Principal Investigator

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Investigate the adhesion molecules that control the progression of endometriosis.Principal Investigator

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Hashimoto Kae 橋本香映

HASHIMOTO Kae 橋本香映