Nishiyama Tomoko 西山朋子

Researcher Number	90615535
Affiliation (Current)	2025: 京都大学, 理学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 京都大学, 理学研究科, 教授 2021: 名古屋大学, 理学研究科, 客員教授 2020: 名古屋大学, 理学研究科, 教授 2017 – 2020: 名古屋大学, 理学研究科, 准教授 2016: 名古屋大学, 理学(系)研究科(研究院), 准教授 2013 – 2015: 名古屋大学, 高等研究院(理), 特任講師
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Basic Section 43010:Molecular biology-related / Molecular and Genome biology and related fields / Molecular biology
Keywords	Principal Investigator 姉妹染色分体間接着 / コヒーシン / ゲノム高次構造 / DNA複製 / DNA物性 / 染色体構築原理 / 間期クロマチン構造 / クロマチン高次構造形成 / SMC / DNAループ … More / クロマチン高次構造 / セントロメア / アセチル化 / ヘテロクロマチン / クロマチン / 一分子解析系 / 染色分体間接着 / 染色体構造構築 / 染色体構築 / 一分子観察 / 染色体ダイナミクス / 単分子解析 Less

ツメガエル初期胚型エピコードの解明Principal Investigator
- Principal Investigator
  
  西山朋子
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
DNA複製と共役する姉妹染色分体間接着機構の一分子動態理解Principal Investigator
- Principal Investigator
  
  西山朋子
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
  Nagoya University
セントロメア近傍領域におけるコヒーシンアセチル化維持機構の解明Principal Investigator
- Principal Investigator
  
  西山朋子
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Genome modality in interphase genome structurePrincipal Investigator
- Principal Investigator
  
  西山朋子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
  Nagoya University
Genome modality: understanding physical properties of the genomeArea Organizer
- Area Organizer
  
  西山朋子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
Genome modality: understanding physical properties of the genomePrincipal Investigator
- Principal Investigator
  
  西山朋子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
  Nagoya University
一分子再構成系を用いた染色分体間接着マシナリーの理解Principal Investigator
- Principal Investigator
  
  西山朋子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Nagoya University
Understanding of spatial regulation of sister chromatid cohesionPrincipal Investigator
- Principal Investigator
  
  Nishiyama Tomoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Nagoya University
Identification of self-assembly activity on mitotic chromosomePrincipal Investigator
- Principal Investigator
  
  Nishiyama Tomoko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Molecular and Genome biology and related fields
- Research Institution
  Nagoya University
Understanding of cohesin dynamics during cell cycle at single molecule resolutionPrincipal Investigator
- Principal Investigator
  
  Nishiyama Tomoko
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Nagoya University

All 2022 2021 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

[Book] 教科書を書き換えろ！染色体の新常識　第3章-32018
- Author(s)
  西山朋子
- Total Pages
  214
- Publisher
  羊土社
- ISBN
  9784758103749
- Data Source
  KAKENHI-PUBLICLY-18H04711
[Journal Article] Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit2022
- Author(s)
  S. Tane, K. Shintomi, K. Kinoshita, Y. Tsubota, M. M. Yoshida, T. Nishiyama, and T. Hirano
- Journal Title
  
  eLife
  
  Volume: 11 Pages: 1-23
- DOI
  10.7554/elife.84694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05938, KAKENHI-PROJECT-19K06499, KAKENHI-PROJECT-20K15723, KAKENHI-PLANNED-19H05755, KAKENHI-PROJECT-23K23815, KAKENHI-PLANNED-20H05937, KAKENHI-PROJECT-18H05276
[Journal Article] A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping2022
- Author(s)
  Kinoshita Kazuhisa、Tsubota Yuko、Tane Shoji、Aizawa Yuuki、Sakata Ryota、Takeuchi Kozo、Shintomi Keishi、Nishiyama Tomoko、Hirano Tatsuya
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 221 Issue: 3
- DOI
  10.1083/jcb.202109016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05755, KAKENHI-PROJECT-19K06499, KAKENHI-PLANNED-20H05937, KAKENHI-PLANNED-20H05938, KAKENHI-PROJECT-18H05276
[Journal Article] Opening of cohesin’s SMC ring is essential for timely DNA replication and DNA loop formation2021
- Author(s)
  Sakata Ryota、Niwa Kyoma、Ugarte La Torre Diego、Gu Chenyang、Tahara Eri、Takada Shoji、Nishiyama Tomoko
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 4 Pages: 1-13
- DOI
  10.1016/j.celrep.2021.108999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05385, KAKENHI-PROJECT-18H02372, KAKENHI-PLANNED-20H05934, KAKENHI-PLANNED-20H05937, KAKENHI-PROJECT-21H04767
[Journal Article] Compartments in the Ring2019
- Author(s)
  Nishiyama Tomoko
- Journal Title
  
  Molecular Cell
  
  Volume: 75 Issue: 2 Pages: 201-203
- DOI
  10.1016/j.molcel.2019.07.002
- Data Source
  KAKENHI-PUBLICLY-18H04711, KAKENHI-PROJECT-18H02372
[Journal Article] Cohesion and cohesin-dependent chromatin organization2019
- Author(s)
  Nishiyama Tomoko
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 印刷中 Pages: 8-14
- DOI
  10.1016/j.ceb.2018.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04711, KAKENHI-PROJECT-18H02372
[Journal Article] Drosophila Dalmatian combines sororin and shugoshin roles in establishment and protection of cohesion2017
- Author(s)
  Takashi Yamada, Eri Tahara, Mai Kanke, Keiko Kuwata, Tomoko Nishiyama
- Journal Title
  
  EMBO Journal
  
  Volume: 印刷中 Issue: 11 Pages: 1513-1527
- DOI
  10.15252/embj.201695607
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25711002
[Journal Article] Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA.2016
- Author(s)
  Mai Kanke, Eri Tahara, Pim J Huis in’t Veld, Tomoko Nishiyama
- Journal Title
  
  The EMBO Journal
  
  Volume: 35 Issue: 24 Pages: 2686-2698
- DOI
  10.15252/embj.201695756
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J04283, KAKENHI-PROJECT-25711002
[Journal Article] Wapl is an essential regulator of chromatin structure and chromosome segregation2013
- Author(s)
  Tedeschi A, Wutz G, Huet S, Jaritz M, Wuensche A, Schirghuber E, Davidson IF, Tang W, Cisneros DA, Bhaskara V, Nishiyama T, Vaziri A, Wutz A, Ellenberg J, Peters JM
- Journal Title
  
  Nature
  
  Volume: 501 Issue: 7468 Pages: 564-568
- DOI
  10.1038/nature12471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25711002
[Journal Article] Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin2013
- Author(s)
  Nishiyama T, Sykora MM, Huis In 't Veld PJ, Mechtler K, Peters JM
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 110 Issue: 33 Pages: 13404-13409
- DOI
  10.1073/pnas.1305020110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] Ring structure of cohesin is essential for genome structure and functions2022
- Author(s)
  Tomoko Nishiyama
- Organizer
  第74回　日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] コヒーシンの構造が制御する染色体機能2022
- Author(s)
  西山朋子
- Organizer
  遺伝研究会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Single-molecule approaches for understanding chromosome architecture2022
- Author(s)
  Tomoko Nishiyama
- Organizer
  30th Hot Spring Harbor International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04767
[Presentation] Ring conformation of cohesin regulates DNA loop extrusion and genome functions2022
- Author(s)
  Tomoko Nishiyama
- Organizer
  第45回　日本分子生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Single-molecule approaches for understanding chromosome architecture2022
- Author(s)
  Tomoko Nishiyama
- Organizer
  30th Hot Spring Harbor International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Alteration of cohesin ring conformation regulates DNA loop extrusion and genome functions2022
- Author(s)
  Tomoko Nishiyama
- Organizer
  Genome organisation by SMC complexes
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Opening cohesin's ring structure is essential for genome functions2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  44th Annual Meeting of the Molecular Biology Society in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04767
[Presentation] Cohesin’s ring structure and genome functions2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  59th Annual Meeting of the Biophysical Society in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Cohesin’s ring structure and genome functions2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  59th Annual Meeting of the Biophysical Society in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04767
[Presentation] Single-molecule approaches for understanding genome architecture2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  2nd ASHBi SignAC Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04767
[Presentation] Opening cohesin's ring structure is essential for genome functions2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  44th Annual Meeting of the Molecular Biology Society in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Single-molecule approaches for understanding genome architecture2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  2nd ASHBi SignAC Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Opening of cohesin’s Smc ring is essential for timely DNA replication2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  第38回　染色体ワークショップ
- Data Source
  KAKENHI-PLANNED-20H05937
[Presentation] Opening of cohesin’s Smc ring is essential for timely DNA replication2021
- Author(s)
  Tomoko Nishiyama
- Organizer
  第38回染色体ワークショップ
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05385
[Presentation] コヒーシンの構造とゲノム機能2019
- Author(s)
  西山朋子
- Organizer
  国立遺伝学研究所研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04711
[Presentation] コヒーシンの構造とゲノム機能2019
- Author(s)
  西山朋子
- Organizer
  国立遺伝学研究所研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02372
[Presentation] Observation of single-cohesin molecules reveals cohesin-dependent alteration of DNA structure2018
- Author(s)
  Tomoko Nishiyama
- Organizer
  EMBL Symposia "Principles of Chromosome Structure and Function"
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04711
[Presentation] Impacts of cohesin ring conformation on the translocation and DNA replication2018
- Author(s)
  Tomoko Nishiyama
- Organizer
  3C & 3R
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02372
[Presentation] ツメガエル卵抽出液を用いた単分子DNA上におけるコヒーシンダイナミクスの解析2017
- Author(s)
  西山朋子
- Organizer
  第35回　染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] 染色体分配のメカニクスとその分子制御2017
- Author(s)
  西山朋子
- Organizer
  ChemBio ハイブリッドレクチャー
- Invited
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] Cohesin dynamics on single DNA in Xenopus egg extracts2017
- Author(s)
  Tomoko Nishiyama
- Organizer
  The 2nd SMC meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] 姉妹染色分体間接着と染色体分配のメカニクス2017
- Author(s)
  西山　朋子
- Organizer
  日本機械学会第 29 回バイオエンジニアリング講演会
- Place of Presentation
  Nagoya
- Year and Date
  2017-01-20
- Invited
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] 接着因子ダイナミクスから読み解く姉妹染色分体間接着機構2017
- Author(s)
  西山朋子
- Organizer
  次世代両生類研究会
- Invited
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] Dalmatian is essential for protection of heterochromatin-based sister chromatid cohesion2016
- Author(s)
  Tomoko Nishiyama
- Organizer
  10th 3R symposium
- Place of Presentation
  Matsue
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] Dalmatian is essential for Heterochromatin-based establishment of sister-chromatid cohesion2015
- Author(s)
  Tomoko Nishiyama
- Organizer
  EMBO workshop: SMC proteins
- Place of Presentation
  Vienna
- Year and Date
  2015-05-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] ショウジョウバエ細胞における Dalmatian の細胞内動態解析2014
- Author(s)
  山田崇、西山朋子
- Organizer
  第 32 回染色体ワークショップ
- Place of Presentation
  広島
- Year and Date
  2014-12-15
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] ヘテロクロマチンを基盤とした姉妹染色分体間接着機構2014
- Author(s)
  西山朋子
- Organizer
  第 32 回染色体ワークショップ
- Place of Presentation
  広島
- Year and Date
  2014-12-15
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] 姉妹染色分体間接着の確立と解離の時空間制御2013
- Author(s)
  西山朋子
- Organizer
  日本細胞生物学会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-25711002
[Presentation] Regulation of cohesin dynamics in entry into mitosis2013
- Author(s)
  Nishiyama T
- Organizer
  The 18th IMCB Symposium
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-25711002

1. 前島一博 (00392118)

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2. 瀧ノ上正浩 (20511249)

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3. 岡田由紀 (60546430)

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4. 白髭克彦 (90273854)

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5. HIRANO Tatsuya

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6. SHINTOMI Keishi

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Nishiyama Tomoko 西山 朋子

Research Projects

Research Products

Co-Researchers

ツメガエル初期胚型エピコードの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA複製と共役する姉妹染色分体間接着機構の一分子動態理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

セントロメア近傍領域におけるコヒーシンアセチル化維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome modality in interphase genome structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome modality: understanding physical properties of the genomeArea Organizer

Area Organizer

Project Period (FY)

Research Category

Genome modality: understanding physical properties of the genomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

一分子再構成系を用いた染色分体間接着マシナリーの理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Understanding of spatial regulation of sister chromatid cohesionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of self-assembly activity on mitotic chromosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding of cohesin dynamics during cell cycle at single molecule resolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 教科書を書き換えろ！染色体の新常識 第3章-32018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Opening of cohesin’s SMC ring is essential for timely DNA replication and DNA loop formation2021

Author(s)

Journal Title

Nishiyama Tomoko 西山朋子

[Book] 教科書を書き換えろ！染色体の新常識　第3章-32018