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Taguchi Kazuaki  田口 和明

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TAGUCHI Kazuaki  田口 和明

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Researcher Number 90621912
Other IDs
Affiliation (Current) 2025: 広島大学, 医系科学研究科(薬), 教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 慶應義塾大学, 薬学部(芝共立), 准教授
2018 – 2020: 慶應義塾大学, 薬学部(芝共立), 講師
2013 – 2017: 崇城大学, 薬学部, 助教
2012: 熊本大学, 医学部附属病院, 薬剤師
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 90120:Biomaterials-related / Medium-sized Section 90:Biomedical engineering and related fields
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Keywords
Principal Investigator
ヘモグロビン / 一酸化炭素 / リポソーム / サイトカインストーム / マクロファージ / アルブミン / MRI / メトヘモグロビン / クラッシュシンドローム / クラッシュ・シンドローム … More / 赤血球 / 急性腎傷害 / 輸血関連急性肺傷害 / 敗血症 / 肺 / 特発性肺線維症 … More
Except Principal Investigator
低分子抗体 / 多機能性アルブミン / 低分子抗体医薬 / 低分子抗体融合体 / 融合技術 / 抗腫瘍効果 / 送達システム / 担体 / がん治療 / タンパク工学 / 体内動態 / 抗体医薬 / アルブミン / リポソーム / 抗酸化アルブミン / 機能性アルブミン / 体内動態特性 / ハイブリッド型抗酸化アルブミン / 包括的放射線防護療法 / 組織指向性機能性アルブミン Less
  • Research Projects

    (7 results)
  • Research Products

    (84 results)
  • Co-Researchers

    (11 People)
  •  ヘモグロビンを基盤とした次世代型高感度ナノMRI造影剤の開発Principal Investigator

    • Principal Investigator
      田口 和明
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Keio University
  •  サイトカインストーム制圧を目指したマクロファージ標的化一酸化炭素ナノ供与体の創製Principal Investigator

    • Principal Investigator
      田口 和明
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      Keio University
  •  Development of Innovative Antibody Drugs using Multifunctional Albumin as a Carrier for Low-molecular-weight Antibodies

    • Principal Investigator
      Otagiri Masaki
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Sojo University
  •  Therapeutic effects of carbon monoxide-bound Hemoglobin-vesicles against disaster-related syndormePrincipal Investigator

    • Principal Investigator
      Taguchi Kazuaki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Keio University
      Sojo University
  •  Development of novel hybrid anti-oxidant based on albumin fusion technology and its therapeutic application on acute radiation syndrome

    • Principal Investigator
      OTAGIRI Masaki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Sojo University
  •  Carbon monoxide-bound hemoglobin-vesicles as a novel resuscitative fluid with multiple effectsPrincipal Investigator

    • Principal Investigator
      TAGUCHI Kazuaki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Sojo University
  •  Carbon monoxide-bound hemoglobin-vesicles as a potential therapeutic agent for the treatment of bleomycin-induced pulmonary fibrosisPrincipal Investigator

    • Principal Investigator
      TAGUCHI Kazuaki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Sojo University
      Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell.2023

    • Author(s)
      Suzuki Y, Arakida Y, Sakai H, Enoki Y, Matsumoto K, Taguchi K.
    • Journal Title

      Toxicol Appl Pharmacol.

      Volume: 481 Pages: 116752-116752

    • DOI

      10.1016/j.taap.2023.116752

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19942, KAKENHI-PROJECT-23KJ1888
  • [Journal Article] Carbon Monoxide-Loaded Red Blood Cell Prevents the Onset of Cisplatin-Induced Acute Kidney Injury.2023

    • Author(s)
      Nagasaki T, Maeda H, Yanagisawa H, Nishida K, Kobayashi K, Wada N, Noguchi I, Iwakiri R, Taguchi K, Sakai H, Saruwatari J, Watanabe H, Otagiri M, Maruyama T.
    • Journal Title

      Antioxidants (Basel).

      Volume: 12 Issue: 9 Pages: 1705-1705

    • DOI

      10.3390/antiox12091705

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K25213, KAKENHI-PROJECT-23K28431
  • [Journal Article] Pharmaceutical Integrity of Lyophilized Methemoglobin-Albumin Clusters after Reconstitution.2023

    • Author(s)
      Suzuki Y, Taguchi K, Okamoto W, Enoki Y, Komatsu T, Matsumoto K.
    • Journal Title

      ACS Omega.

      Volume: 8 Issue: 25 Pages: 22589-22595

    • DOI

      10.1021/acsomega.3c01054

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K25213
  • [Journal Article] Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning.2022

    • Author(s)
      Suzuki Y, Taguchi K, Kure T, Enoki Y, Otagiri M, Sakai H, Matsumoto K.
    • Journal Title

      Toxicol Appl Pharmacol.

      Volume: 450 Pages: 116159-116159

    • DOI

      10.1016/j.taap.2022.116159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19942
  • [Journal Article] A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease2022

    • Author(s)
      Nagasaki Taisei、Maeda Hitoshi、Taguchi Kazuaki、Yanagisawa Hiroki、Nishida Kento、Kobayashi Kazuki、Wada Naoki、Noguchi Isamu、Murata Ryota、Sakai Hiromi、Kitagishi Hiroaki、Saruwatari Junji、Watanabe Hiroshi、Otagiri Masaki、Maruyama Toru
    • Journal Title

      Redox Biology

      Volume: 54 Pages: 102371-102371

    • DOI

      10.1016/j.redox.2022.102371

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K15315, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-23K25213
  • [Journal Article] Research of storable and ready-to-use artificial red blood cells (hemoglobin vesicles) for emergency medicine and other clinical applications.2022

    • Author(s)
      Sakai H, Kure T, Taguchi K, Azuma H.
    • Journal Title

      Front Med Technol.

      Volume: 4 Pages: 1048951-1048951

    • DOI

      10.3389/fmedt.2022.1048951

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19942, KAKENHI-PROJECT-21H03824, KAKENHI-PROJECT-23K25213
  • [Journal Article] Pharmacokinetics of 4′-cyano-2′-deoxyguanosine, a novel nucleoside analog inhibitor of the resistant hepatitis B virus, in a rat model of chronic kidney disease2021

    • Author(s)
      Hashimoto Mai、Taguchi Kazuaki、Imoto Shuhei、Yamasaki Keishi、Mitsuya Hiroaki、Otagiri Masaki
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 5 Pages: 702-706

    • DOI

      10.1016/j.jiac.2020.12.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K06995
  • [Journal Article] When Albumin Meets Liposomes: A Feasible Drug Carrier for Biomedical Applications.2021

    • Author(s)
      Taguchi K, Okamoto Y, Matsumoto K, Otagiri M, Chuang VTG.
    • Journal Title

      Pharmaceuticals (Basel)

      Volume: 14 Issue: 4 Pages: 296-296

    • DOI

      10.3390/ph14040296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Journal Article] Liposomal Artificial Red Blood Cell-Based Carbon Monoxide Donor Is a Potent Renoprotectant against Cisplatin-Induced Acute Kidney Injury2021

    • Author(s)
      Taguchi Kazuaki、Suzuki Yuto、Tsutsuura Moeko、Hiraoka Kana、Watabe Yuki、Enoki Yuki、Otagiri Masaki、Sakai Hiromi、Matsumoto Kazuaki
    • Journal Title

      Pharmaceutics

      Volume: 14 Issue: 1 Pages: 57-57

    • DOI

      10.3390/pharmaceutics14010057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H03824, KAKENHI-PROJECT-23K25213
  • [Journal Article] Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles2020

    • Author(s)
      Tokuno Masahiro、Taguchi Kazuaki、Sakai Hiromi、Ohtsuki Sumio、Yamasaki Keishi、Otagiri Masaki
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 35 Issue: 5 Pages: 417-424

    • DOI

      10.1016/j.dmpk.2020.06.004

    • NAID

      50014592883

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K06995
  • [Journal Article] Characterization of the Interaction of Daptomycin With Site II on Human Serum Albumin2020

    • Author(s)
      Yamasaki Keishi、Sakurama Keiki、Nishi Koji、Watanabe Hiroshi、Maruyama Toru、Seo Hakaru、Otagiri Masaki、Taguchi Kazuaki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 9 Pages: 2919-2924

    • DOI

      10.1016/j.xphs.2020.06.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20K06995
  • [Journal Article] Carbon monoxide rescues the developmental lethality of experimental rat models of rhabdomyolysis-induced acute kidney injury2020

    • Author(s)
      Taguchi K, Ogaki S, Nagasaki T, Yanagisawa H, Nishida K, Maeda H, Enoki Y, Matsumoto K, Sekijima H, Ooi K, Ishima Y, Watanabe H, Fukagawa M, Otagiri M, Maruyama T
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 372(3) Issue: 3 Pages: 355-365

    • DOI

      10.1124/jpet.119.262485

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-17K08481, KAKENHI-PROJECT-18H02587
  • [Journal Article] Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats2020

    • Author(s)
      Tokuno Masahiro、Taguchi Kazuaki、Sakai Hiromi、Ohtsuki Sumio、Yamasaki Keishi、Otagiri Masaki
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 35 Issue: 5 Pages: 425-431

    • DOI

      10.1016/j.dmpk.2020.06.005

    • NAID

      50014592884

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K06995
  • [Journal Article] Hepatic Cytochrome P450 Profiles in Hemorrhagic Shock Model Rats After Transfusion With Stored Red Blood Cells2020

    • Author(s)
      Tokuno Masahiro、Taguchi Kazuaki、Yamasaki Keishi、Otagiri Masaki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 11 Pages: 3490-3495

    • DOI

      10.1016/j.xphs.2020.08.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K06995
  • [Journal Article] Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique.2019

    • Author(s)
      Kimura K, Yamasaki K, Nishi K, Taguchi K, Otagiri M
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 83 Issue: 6 Pages: 1113-1120

    • DOI

      10.1007/s00280-019-03832-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-17K08261
  • [Journal Article] Preparation, Characterization, and in Vitro/in Vivo Evaluation of Paclitaxel-Bound Albumin-Encapsulated Liposomes for the Treatment of Pancreatic Cancer2019

    • Author(s)
      Okamoto Yuko、Taguchi Kazuaki、Sakuragi Mina、Imoto Shuhei、Yamasaki Keishi、Otagiri Masaki
    • Journal Title

      ACS Omega

      Volume: 4 Issue: 5 Pages: 8693-8700

    • DOI

      10.1021/acsomega.9b00537

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-17K08261
  • [Journal Article] Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity.2018

    • Author(s)
      Taguchi K, Nagao S, Maeda H, Yanagisawa H, Sakai H, Yamasaki K, Wakayama T, Watanabe H, Otagiri M, Maruyama T
    • Journal Title

      Drug Deliv

      Volume: 25 Issue: 1 Pages: 1266-1274

    • DOI

      10.1080/10717544.2018.1477860

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-17K08481, KAKENHI-PROJECT-18H02604
  • [Journal Article] Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications2018

    • Author(s)
      Taguchi Kazuaki、Maruyama Toru、Otagiri Masaki
    • Journal Title

      Current Medicinal Chemistry

      Volume: in press Issue: 18 Pages: 2949-2963

    • DOI

      10.2174/0929867325666181113122340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Journal Article] Safety Evaluation of Cellular-type Artificial Blood Based on Pharmacokinetic Analysis and Its Use in Medical Gas Delivery2018

    • Author(s)
      Taguchi Kazuaki
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 11 Pages: 1381-1389

    • DOI

      10.1248/yakushi.18-00127

    • NAID

      130007502962

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-11-01
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Journal Article] The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders.2017

    • Author(s)
      Taguchi K, Yamasaki K, Sakai H, Maruyama T, Otagiri M
    • Journal Title

      J Pharm Sci

      Volume: 106 Issue: 9 Pages: 2392-2400

    • DOI

      10.1016/j.xphs.2017.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-17K08481, KAKENHI-PROJECT-17H02087
  • [Journal Article] The Binding of Silibinin, the Main Constituent of Silymarin, to Site I on Human Serum Albumin2017

    • Author(s)
      Yamasaki K, Sato H, Minagoshi S, Kyubun K, Anraku M, Miyamura S, Watanabe H, Taguchi K, Seo H, Maruyama T, Otagiri M
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 3 Pages: 310-317

    • DOI

      10.1248/bpb.b16-00790

    • NAID

      130005398492

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-17K08480
  • [Journal Article] Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers.2017

    • Author(s)
      Taguchi K, Yamasaki K, Maruyama T, Otagiri M.
    • Journal Title

      J Funct Biomater.

      Volume: 8 Issue: 1 Pages: 0-0

    • DOI

      10.3390/jfb8010011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-17K08481
  • [Journal Article] Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury.2016

    • Author(s)
      Tokuno M, Taguchi K, Yamasaki K, Sakai H, Otagiri M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0165557-e0165557

    • DOI

      10.1371/journal.pone.0165557

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Journal Article] Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis2016

    • Author(s)
      Nagao S, Taguchi K, Miyazaki Y, Wakayama T, Chuang VT, Yamasaki K, Watanabe H, Sakai H, Otagiri M, Maruyama T
    • Journal Title

      J Control Release.

      Volume: 234 Pages: 49-58

    • DOI

      10.1016/j.jconrel.2016.05.016

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15J09957, KAKENHI-PROJECT-26860121
  • [Journal Article] Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties.2016

    • Author(s)
      Nagao S, Taguchi K, Sakai H, Yamasaki K, Watanabe H, Otagiri M, Maruyama T
    • Journal Title

      Int J Nanomedicine.

      Volume: 11 Pages: 5611-5620

    • DOI

      10.2147/ijn.s118185

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15J09957, KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-26860121
  • [Journal Article] Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants.2015

    • Author(s)
      Anraku M, Shintomo R, Taguchi K, Kragh-Hansen U, Kai T, Maruyama T, Otagiri M.
    • Journal Title

      Life Sci.

      Volume: 134 Pages: 36-41

    • DOI

      10.1016/j.lfs.2015.05.010

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460248, KAKENHI-PROJECT-15K15008
  • [Journal Article] Safety Evaluation of Hemoglobin-Albumin Cluster "HemoAct" as a Red Blood Cell Substitute.2015

    • Author(s)
      Haruki R, Kimura T, Iwasaki H, Yamada K, Kamiyama I, Kohno M, Taguchi K, Nagao S, Maruyama T, Otagiri M, Komatsu T.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 12778-12778

    • DOI

      10.1038/srep12778

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-15K15185, KAKENHI-PROJECT-15H04758
  • [Journal Article] Biological Responsiveness and Metabolic Performance of Liposome-Encapsulated Hemoglobin (Hemoglobin-Vesicles) in Apolipoprotein E-Deficient Mice after Massive Intravenous Injection2015

    • Author(s)
      Taguchi K, Nagao S, Yamasaki K, Sakai H, Seo H, Maruyama T, Otagiri M.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 10 Pages: 1606-1616

    • DOI

      10.1248/bpb.b15-00420

    • NAID

      130005101572

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Journal Article] Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats.2014

    • Author(s)
      Ogaki S, Taguchi K, Watanabe H, Ishima Y, Otagiri M, Maruyama T.
    • Journal Title

      J Pharm Sci.

      Volume: 103 Issue: 7 Pages: 2199-2206

    • DOI

      10.1002/jps.24029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860121
  • [Journal Article] Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis.2014

    • Author(s)
      Nagao S, Taguchi K, Sakai H, Tanaka R, Horinouchi H, Watanabe H, Kobayashi K, Otagiri M, Maruyama T.
    • Journal Title

      Biomaterials.

      Volume: 35 Issue: 24 Pages: 6553-6562

    • DOI

      10.1016/j.biomaterials.2014.04.049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24790159, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860121
  • [Journal Article] Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia.2014

    • Author(s)
      Miyazaki Y, Taguchi K, Sou K, Watanabe H, Ishima Y, Miyakawa T, Mitsuya H, Fukagawa M, Otagiri M, Maruyama T.
    • Journal Title

      Mol Pharm.

      Volume: 11 Issue: 11 Pages: 4238-4248

    • DOI

      10.1021/mp500453a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-25860118, KAKENHI-PROJECT-26860121
  • [Journal Article] Pharmacokinetic study of adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute in an anticancer drug-induced thrombocytopenia rat model.2013

    • Author(s)
      Taguchi K, Ujihira H, Watanabe H, Fujiyama A, Doi M, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
    • Journal Title

      J Pharm Sci.

      Volume: 102 Issue: 10 Pages: 3852-9

    • DOI

      10.1002/jps.23692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Journal Article] Carbon Monoxide Bound Red Blood Cells Protect Red Blood Cell Transfusion-induced Hepatic Cytochrome P450 Impairment in Hemorrhagic-shock Rats. Drug Metab Dispos.2013

    • Author(s)
      Ogaki S, Taguchi K, Watanabe H, Otagiri M, and Maruyama T.
    • Journal Title

      Drug Metab Dispos.

      Volume: 41 Issue: 1 Pages: 141-8

    • DOI

      10.1124/dmd.112.048744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24790159
  • [Journal Article] A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency.2013

    • Author(s)
      Taguchi K
    • Journal Title

      Scand J Infect Dis.

      Volume: 45(1) Issue: 1 Pages: 77-80

    • DOI

      10.3109/00365548.2012.708783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Journal Article] Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute.2013

    • Author(s)
      Taguchi K, Ujihira H, Ogaki S, Watanabe H, Fujiyama A, Doi M, Okamura Y, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
    • Journal Title

      Drug Metab Dispos.

      Volume: 41 Issue: 8 Pages: 1584-91

    • DOI

      10.1124/dmd.112.050005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Journal Article] Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model.2012

    • Author(s)
      Kaga M, Li H, Ohta H, Taguchi K, Ogaki S, Izumi H, Inagaki M, Tsuchiya S, Okamura K, Otagiri M, Sakai H, and Yaegashi N.
    • Journal Title

      Life Sci.

      Volume: 91 Issue: 11-12 Pages: 420-8

    • DOI

      10.1016/j.lfs.2012.08.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24790159
  • [Journal Article] Pharmaceutical aspects of the recombinant human serum albumin dimer: structural characteristics, biological properties, and medical applications.2012

    • Author(s)
      Taguchi K, Chuang VT, Maruyama T, Otagiri M.
    • Journal Title

      J Pharm Sci.

      Volume: 101 Issue: 9 Pages: 3033-46

    • DOI

      10.1002/jps.23181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24790159
  • [Presentation] 良質な薬物治療を目指したアカデミア創薬・育薬研究2024

    • Author(s)
      田口和明
    • Organizer
      日本薬学会第144年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K25213
  • [Presentation] 一酸化炭素を基盤とした急性呼吸窮迫症候群に対する新規治療法の検討2022

    • Author(s)
      渡部 佑樹、田口 和明、榎木 裕紀、小田切 優樹、酒井 宏水、松元 一明
    • Organizer
      第29回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-23K25213
  • [Presentation] 一酸化炭素結合型ヘモグロビン小胞体の薬剤誘発性臓器傷害に対する抑制効果2022

    • Author(s)
      田口和明、酒井宏水、小田切優樹、松元一明
    • Organizer
      第29回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-22K19942
  • [Presentation] 一酸化炭素結合型ヘモグロビン小胞体の薬剤誘発性臓器傷害に対する抑制効果2022

    • Author(s)
      田口和明、酒井宏水、小田切優樹、松元一明
    • Organizer
      第29回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-23K25213
  • [Presentation] アルブミン内包リポソームの設計と評価:アルブミン内封量に及ぼす脂質電荷の影響2021

    • Author(s)
      長谷川 喬史、西 弘二、岡本 侑子、田口 和明、月川 健士、小田切 優樹、山﨑 啓之
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] アルブミン内包リポソームの設計と評価:アルブミン内封量に及ぼす脂質電荷の影響2021

    • Author(s)
      長谷川喬史、西弘二、岡本侑子、田口和明、月川健士、小田切優樹、山﨑啓之
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 存赤血球輸血が肝cytochromeP450に与える影響2020

    • Author(s)
      田口 和明、得能 正裕、山崎 啓之、小田切 優樹
    • Organizer
      第27回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] ヘモグロビンを担体とした一酸化炭素デリバリーシステムによる腎疾患治療戦略2020

    • Author(s)
      永﨑 太清、前田 仁志、田口 和明、柳澤 洋輝、西田 健人、酒井 宏水、深川 雅史、渡邊 博志、小田切 優樹、丸山  徹
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] B型肝炎ウイルス新規治療候補薬の健常ラット及び腎障害モデルラットにおける体内動態解析2020

    • Author(s)
      橋本 麻衣、田口 和明、山﨑 啓之、井本 修平、満屋 裕明、小田切 優樹
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 潰瘍性大腸炎モデルマウスにおけるラクトフェリンナノ粒子の治療効果2020

    • Author(s)
      渡部 佑樹、田口 和明、榎木 裕紀、酒井 宏水、丸山 徹、小田切 優樹、河野 光智、松元 一明
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 一酸化炭素付加機能性赤血球は包括的に急性腎障害の病態を改善する2020

    • Author(s)
      永崎 太清、田口 和明、柳澤 洋輝、西田 健人、前田 仁志、酒井 宏水、渡邊 博志、深川 雅史、小田切 優樹、丸山 徹
    • Organizer
      第27回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 潰瘍性大腸炎モデルマウスにおけるラクトフェリンナノ粒子の治療効果2020

    • Author(s)
      田口 和明、橋本 麻衣、中山 真雪、榎木 裕紀、西 弘二、松元 一明、瀬尾 量、小田切 優樹、山﨑 啓之
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 一酸化炭素結合型ヘモグロビン小胞体の閉塞性細気管支炎に対する有効性評価2020

    • Author(s)
      渡部 佑樹、田口 和明、榎木 裕紀、酒井 宏水、丸山 徹、小田切 優樹、河野 光智、松元 一明
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 生理活性ガス一酸化炭素のバイオミメティックDDS2019

    • Author(s)
      田口 和明、松元 一明、丸山 徹、小田切 優樹
    • Organizer
      第35回日本DDS学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] 脱溶媒和法により調製したドキソルビシン封入ヒト血清アルブミンナノ粒子の抗腫瘍効果に関する検討2019

    • Author(s)
      山崎啓之、木村虎太郎、西弘二、猪原彩希、大島千佳、井本修平、田口和明、小田切優樹
    • Organizer
      第35回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] パクリタキセルーアルブミン内包リポソームの乳癌治療への応用2019

    • Author(s)
      田口 和明、岡本 侑子、山崎 啓之、小田切 優樹
    • Organizer
      日本薬剤学会第34年会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] Biosafety and in vivo gene delivery studies of nanoparticles based on albumin-PDMAEMA conjugation2019

    • Author(s)
      Taguchi K, Lu H, Jiang Y, Hung T, Stenzel MH
    • Organizer
      10th International Nanomedicine Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] Carbon monoxide bound Hemoglobin-vesicles are effective in treating inflammatory disorders2019

    • Author(s)
      Taguchi K, Maruyama T, Sakai H, Otagiri M
    • Organizer
      The 17th International Symposium on Blood Substitutes and Oxygen Therapeutics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] ヘモグロビンの生理活性ガス運搬能を利用した創薬戦略2019

    • Author(s)
      田口和明、松元一明、丸山徹、小田切優樹
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] 一酸化炭素結合型ヘモグロビン小胞体の急性膵炎治療への応用2018

    • Author(s)
      田口和明、永尾紗理、酒井宏水、丸山徹、小田切優樹
    • Organizer
      第25回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] 一酸化炭素結合型ヘモグロビン小胞体の抗炎症作用機序の解明と急性膵炎治療への応用2018

    • Author(s)
      田口和明、永尾紗理、前田仁志、酒井宏水、山崎啓之、丸山徹、小田切優樹
    • Organizer
      日本薬剤学会第33年会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] Pharmaceutical Application of Recombinant Human Serum Albumin Dimer2018

    • Author(s)
      Masaki Otagiri, Kazuaki Taguchi, Keishi Yamasaki, Yu Ishima, Toru Maruyama
    • Organizer
      SICHEM2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06810
  • [Presentation] 一酸化炭素結合型ヘモグロビン小胞体の潰瘍性大腸 炎に対する有用性評価2017

    • Author(s)
      田口 和明, 永尾 紗理, 酒井 宏水, 山崎 啓之, 丸山 徹 , 小田切 優樹
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台/宮城県仙台市
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] 細胞型人工赤血球の動態特性解析に基づく安全性評価と医療ガスデリバリーへの応用2017

    • Author(s)
      田口 和明
    • Organizer
      第34回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] 出血性ショックラットに対する長期保存ヘモグロビ ン小胞体投与時の有効性及び安全性評価2017

    • Author(s)
      得能 正裕, 田口 和明 , 山﨑 啓之 , 酒井 宏水, 小田切 優樹
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台/宮城県仙台市
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] Biological responsiveness and pharmacokinetic properties of cellular type hemoglobin based oxygen carrier (Hemoglobin-Vesicles) in hyperlipidemia model mice after massive intravenous injection2017

    • Author(s)
      Taguchi K, Yamasaki K, Sakai H, Maruyama T, Otagiri M
    • Organizer
      6th FIP Pharmaceutical Sciences World Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] 急性膵炎に対する一酸化炭素結合型ヘモグロビン小胞体の有用性評価2017

    • Author(s)
      田口和明、永尾紗理、酒井宏水、山崎啓之、丸山徹、小田切優樹
    • Organizer
      日本薬剤学会第32年会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] Therapeutic application of bone marrow-targeted liposome ~Encapsulation of erythropoietin for renal anemia treatment~2017

    • Author(s)
      Kazuaki Taguchi, Toru Maruyama, Keitaro Sou, Masaki Otagiri
    • Organizer
      International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond the History (ISDDPS)
    • Place of Presentation
      Kyoto Reserch Park(京都府・京都市)
    • Year and Date
      2017-03-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15008
  • [Presentation] ヘモグロビン小胞体の難治性炎症疾患治療薬としての応用使用2017

    • Author(s)
      田口和明,永尾紗理,酒井宏水,山崎啓之,丸山徹,小田切優樹
    • Organizer
      第24回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-17K08481
  • [Presentation] バイオミメティックな一酸化炭素デリバリーによる炎症性腸疾患の治療効果2016

    • Author(s)
      永尾 紗理、田口 和明、酒井 宏水、小田切 優樹、丸山 徹
    • Organizer
      第32回 日本DDS学会学術集会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡県・静岡市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] バイオミメティックな一酸化炭素デリバリーによる炎症性腸疾患の治療効果2016

    • Author(s)
      永尾 紗理、田口 和明、酒井 宏水、小田切 優樹、丸山 徹
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      グランシップ 静岡コンベションアーツセンター(静岡県・静岡市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-15K15008
  • [Presentation] クラッシュ症候群モデルラットに対する一酸化炭素付加赤血球の有用性評価2016

    • Author(s)
      丸山徹、大柿滋、永崎太清、柳澤 洋輝、永尾 紗理、田口 和明、渡邊 博志、小田切 優樹
    • Organizer
      第23回日本血液代替物学会年次大会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京都・新宿区)
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-15K15008
  • [Presentation] ヘモグロビン小胞体蘇生が輸血関連急性肺障害に与える影響2015

    • Author(s)
      得能正裕,田口和明,山﨑啓之,酒井宏水,小田切優樹
    • Organizer
      第22回日本血液代替物学会年次大会
    • Place of Presentation
      熊本大学薬学部・宮本記念館コンベンションホール (熊本市中央区)
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] 炎症性腸疾患に対する一酸化炭素結合型ヘモグロビン小胞体の有用性評価2015

    • Author(s)
      永尾紗理,田口和明,酒井宏水,小田切優樹,丸山徹
    • Organizer
      第22回日本血液代替物学会年次大会
    • Place of Presentation
      熊本大学薬学部・宮本記念館コンベンションホール (熊本市中央区)
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] 細胞型人工酸素運搬体 ヘモグロビン小胞体の体内挙動と安全性評価 ~正常から病態へ~2015

    • Author(s)
      小田切優樹,田口和明,丸山徹,酒井宏水
    • Organizer
      第22回日本血液代替物学会年次大会
    • Place of Presentation
      熊本大学薬学部・宮本記念館コンベンションホール (熊本市中央区)
    • Year and Date
      2015-10-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] The effects of liposomal hemoglobin-based artificial oxygen carriers (hemoglobin-vesicles) and red blood cells resuscitation on transfusion-related acute lung injury in hemorrhagic shock model rats2015

    • Author(s)
      Tokuno M, Taguchi K, Yamasaki K, Sakai H, Otagiri M
    • Organizer
      AFPS2015
    • Place of Presentation
      Bangkok (Thailand)
    • Year and Date
      2015-11-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] Carbon monoxide bound red blood cells protect the expression of hepatic cytochrome P450 after resuscitation from hemorrhagic shock via inactivation of Kupffer cells2013

    • Author(s)
      Ogaki S, Taguchi K, 他
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2013
    • Place of Presentation
      Jeju, Korea
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] 一酸化炭素付加型ヘモグロビン小胞体の特発性肺線維症治療薬としての創製2013

    • Author(s)
      田口和明、永尾紗理、丸山徹、小田切優樹
    • Organizer
      第20回日本血液代替物学会年次大会
    • Place of Presentation
      奈良県新公会堂
    • Invited
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] 一酸化炭素付加型ヘモグロビン小胞体の特発性肺線維症治療薬としての創製2013

    • Author(s)
      田口和明, 他
    • Organizer
      第20回日本血液代替物学会年次大会
    • Place of Presentation
      奈良
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] Preclinical studies of hemoglobin-vesicles as an artificial oxygen carrier in non-human primate2013

    • Author(s)
      Kazuaki Taguchi, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Toru Maruyama, Masaki Otagiri
    • Organizer
      The XIVth International Symposium on Blood Substitutes and Oxygen Therapeutics
    • Place of Presentation
      Chengdu, China
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] 骨髄指向性を有する新規エリスロポエチン製剤の開発2012

    • Author(s)
      宮崎裕理、田口和明、宗慶太郎、小田切優樹、丸山徹
    • Organizer
      日本薬剤学会27年会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] 細胞型人工酸素運搬体ヘモグロビン小胞体のカニクイザルへの大量投与の結果からみた実効性2012

    • Author(s)
      田口和明、酒井宏水、堀之内宏久、小林紘一、丸山徹、小田切優樹
    • Organizer
      第19日本血液代替物学会年次大会
    • Place of Presentation
      旭川大雪クリスタルホール
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] 血小板代替物H12(ADP)リポソームの体内動態に及ぼす血小板減少症の影響2012

    • Author(s)
      10. 丸山徹、田口和明、氏平隼人、渡邊博志、新井愛美、池田康夫、武岡真司、半田誠、小田切優樹
    • Organizer
      第19日本血液代替物学会年次大会
    • Place of Presentation
      旭川大雪クリスタルホール
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] Safety and pharmacokinetic studies of hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin-vesicles, in chronic hepatic cirrhosis.

    • Author(s)
      Taguchi K, Sakai H, Maruyama T, Otagiri M
    • Organizer
      5th FIP Pharmaceutical Sciences World Congress
    • Place of Presentation
      Melbourne convention exhibition center (オーストラリア・メルボルン)
    • Year and Date
      2014-04-13 – 2014-04-16
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] 病態モデル動物におけるヘモグロビン小胞体の体内動態と安全性評価

    • Author(s)
      田口和明、丸山 徹、酒井宏水、小田切優樹
    • Organizer
      第21回日本血液代替物学会年次大会
    • Place of Presentation
      中央大学 (東京都・文京区)
    • Year and Date
      2014-12-08 – 2014-12-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-26860121
  • [Presentation] Preclinical studies of hemoglobin-vesicles as an artificial oxygen carrier in non-human primate

    • Author(s)
      Taguchi K, 他
    • Organizer
      14th International Symposium on Blood Substitutes and Oxygen Therapeutics
    • Data Source
      KAKENHI-PROJECT-24790159
  • [Presentation] ヘモグロビン小胞体の体内動態解析に基づく安全性・有用性評価とDDSへの応用

    • Author(s)
      小田切優樹、田口和明、丸山徹、酒井宏水、小林紘一
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      京王プラザホテル札幌 (北海道・札幌)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-26860121
  • 1.  OTAGIRI Masaki (80120145)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 31 results
  • 2.  異島 優 (00457590)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  森岡 弘志 (20230097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  酒井 宏水 (70318830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 5.  住吉 晃 (80612530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  小松 晃之 (30298187)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  YAMASAKI Keishi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  WATANABE Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 9.  MARUYAMA Toru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 10.  前田 仁志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  安楽 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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