Sahashi Kentaro 佐橋健太郎

Researcher Number	90710103
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 名古屋大学, 医学系研究科, 准教授 2020 – 2023: 名古屋大学, 医学部附属病院, 講師 2016 – 2019: 名古屋大学, 医学部附属病院, 病院助教 2014 – 2016: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Neurology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Neurology / Basic Section 52020:Neurology-related / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator 核酸 / 運動ニューロン疾患 / 神経変性疾患 / 神経変性 / 運動ニューロン / 脊髄性筋萎縮症 / RNA / アンチセンス核酸 / 球脊髄性筋萎縮症 / タンパク質凝集体 … More / シヌクレイン / ポリグルタミン / タンパク質凝集 / 凝集タンパク質 / 低分子干渉RNA / 発達異常 / 運動ニューロン変性 / 髄液 / 軸索 / RNA編集 / リードスルー / 先天性ミオパチー / 分子標的治療 / 病態 / 変異アンドロゲン受容体 / 病態解明 … More Except Principal Investigator 筋萎縮性側索硬化症 / TDP-43 / 運動ニューロン疾患 / 運動ニューロン / ALS / 神経変性疾患 / 球脊髄性筋萎縮症 / オリゴデンドロサイト / シナプス / 胎児 / 転写障害 / 早期病態 / FTLD / DNAメチル化 / ミトコンドリア / 骨格筋 / イオンチャンネル / シングルセル解析 / マルチモーダル解析 / TDP-43ノックインマウス / TDP-43凝集阻害 / コリントランスポーター / 声帯麻痺 / ノックインマウス / SLC5A7 / 遠位型遺伝性運動ニューロパチー / FUS / CRISPR/Cas9 / iPS細胞 / タンパク伝播 / TDP-43伝播 / オリゴデンデロサイト / 凝集タンパク伝播 / TDP-43伝搬 / 異常タンパク凝集 / ニューロン / 凝集タンパク質の細胞間伝播 / prion-like propagation / protein aggregation / RNAseq / アンチセンス核酸 / 運動 / ライフステージ / 神経分化 / 軸索 / Midkine-1 / テストステロン / タンパク質品質管理 / タンパク質品質管理機構 / SBMA / 後根神経節 / エクソソーム / DREADD / 神経活動 / エクソサイト-シス / カルシウムチャンネル / アンドロゲン受容体 / Src / インスリン / エクソサイトーシス / polysome解析 / 前頭側頭葉変性症 / TBK1 / 呼吸機能 / バイオマーカー / シスタチンC / シグナル / リン酸化 / プロテオーム / シグナル伝達 / 神経科学 / 脳神経疾患 / Aktシグナル / NFkB / エピジェネティクス Less

運動ニューロン疾患の神経変性因子に対する標的治療法開発Principal Investigator
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
孤発性ALS病態を反映した動物モデル作成とTDP-43凝集抑制療法の開発
- Principal Investigator
  
  井口洋平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Development of next-generation antisense therapeutics for neurological diseasesPrincipal Investigator
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
ALSに関連する運動ニューロン周囲オリゴデンドロサイトの機能と役割の解明
- Principal Investigator
  
  井口洋平
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases
- Principal Investigator
  
  勝野雅央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Understanding of early axonal pathology in motor neuron diseasesPrincipal Investigator
- Principal Investigator
  
  Sahashi Kentaro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosis
- Principal Investigator
  
  横井聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Reserch to dicover disease pathogenesis of distal hereditary motor neuropathy
- Principal Investigator
  
  Iguchi Yohei
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Therapeutic development against protein aggregationPrincipal Investigator
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Spatio-temporal specificity of neurodegenerative diseases with a focus on very early life stages
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Unraveling mechanisms of In vivo transmission of aggregated TDP-43 in sporadic ALS
- Principal Investigator
  
  Yohei Iguchi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
異常タンパク分解系を標的とした運動ニューロン疾患治療薬の開発
- Principal Investigator
  
  藤内玄規
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Aichi Medical University
  Nagoya University
Understanding of defective developmental gene regulation responsible for motor neuron degenerationPrincipal Investigator
- Principal Investigator
  
  Kentaro Sahashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
Understanding of intrinsic readthrough mechanisms of nonsense mutations for its therapeutic applicationsPrincipal Investigator
- Principal Investigator
  
  Sahashi Kentaro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Discovery of novel target and disease modifying therapy for ALS/FTLD using neuro-specific transcriptome analysis
- Principal Investigator
  
  IGUCHI YOHEI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Elucidation of defective neural communication in motor neuron diseases
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of biomarker and therapy for amyotrophic lateral sclerosis targeting cystatin C
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Therapy development for neuromuscular degeneration in motor neuron diseases
- Principal Investigator
  
  KATSUNO Masahisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Dissection of the pathomechanisms of motor neuron disease using antisense therapeuticsPrincipal Investigator
- Principal Investigator
  
  Sahashi Kentaro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book Patent

[Book] 脳神経疾患最新の治療2021-20232021
- Author(s)
  佐橋健太郎, 勝野雅央
- Total Pages
  380
- Publisher
  南江堂
- ISBN
  9784524227853
- Data Source
  KAKENHI-PROJECT-19H03545
[Journal Article] Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy.2024
- Author(s)
  Hirunagi T, Nakatsuji H, Sahashi K, Yamamoto M, Iida M, Tohnai G, Kondo N, Yamada S, Murakami A, Noda S, Adachi H, Sobue G, Katsuno M.
- Journal Title
  
  J Cachexia Sarcopenia Muscle
  
  Volume: 15 Issue: 1 Pages: 159-172
- DOI
  10.1002/jcsm.13344
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06976, KAKENHI-PROJECT-22K15705, KAKENHI-PROJECT-23H00420
[Journal Article] Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy2023
- Author(s)
  Koike Haruki、Iguchi Yohei、Sahashi Kentaro、Katsuno Masahisa
- Journal Title
  
  eBioMedicine
  
  Volume: 90 Pages: 104526-104526
- DOI
  10.1016/j.ebiom.2023.104526
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K07882
[Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022
- Author(s)
  Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 42 Issue: 47 Pages: 8881-8896
- DOI
  10.1523/jneurosci.0455-22.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-22K07515, KAKENHI-PROJECT-22K07545, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-21K15622, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-23K24249, KAKENHI-PROJECT-23K21410
[Journal Article] Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology2022
- Author(s)
  Tsujikawa K,Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y,Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M, et al.
- Journal Title
  
  Sci Adv
  
  Volume: - Issue: 21 Pages: 1-16
- DOI
  10.1126/sciadv.abm5029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00527, KAKENHI-PROJECT-22K19506, KAKENHI-PUBLICLY-21H05624, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-21K15330, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K21410, KAKENHI-PROJECT-21H03537
[Journal Article] Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy2022
- Author(s)
  Ogura Yosuke、Sahashi Kentaro、Hirunagi Tomoki、Iida Madoka、Miyata Takaki、Katsuno Masahisa
- Journal Title
  
  Cell Death & Disease
  
  Volume: 13 Issue: 7 Pages: 601-601
- DOI
  10.1038/s41419-022-05001-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15705, KAKENHI-PROJECT-20H00527, KAKENHI-PROJECT-21H02656, KAKENHI-PROJECT-21K20686, KAKENHI-PUBLICLY-21H00363
[Journal Article] Nucleic Acid-Based Therapeutic Approach for Spinal and Bulbar Muscular Atrophy and Related Neurological Disorders2022
- Author(s)
  Hirunagi T, Sahashi K, Meilleur KG, Katsuno M.
- Journal Title
  
  Genes
  
  Volume: 13 Issue: 1 Pages: 109-109
- DOI
  10.3390/genes13010109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00527
[Journal Article] Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.2021
- Author(s)
  Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M.
- Journal Title
  
  Mol Ther Nucleic Acids.
  
  Volume: 24 Pages: 1-10
- DOI
  10.1016/j.omtn.2021.02.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00527, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-21K20686, KAKENHI-PROJECT-19H03576
[Journal Article] Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment2021
- Author(s)
  Koike Haruki、Iguchi Yohei、Sahashi Kentaro、Katsuno Masahisa
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 16 Pages: 5091-5091
- DOI
  10.3390/molecules26165091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03589
[Journal Article] NUS1 mutation in a family with epilepsy, cerebellar ataxia, and tremor2020
- Author(s)
  Araki Kunihiko、Nakamura Ryoichi、Ito Daisuke、Kato Kohji、Iguchi Yohei、Sahashi Kentaro、Toyama Miho、Hamada Kensuke、Okamoto Nobuhiko、Wada Yoshinao、Nakamura Tomohiko、Ogi Tomoo、Katsuno Masahisa
- Journal Title
  
  Epilepsy Research
  
  Volume: 164 Pages: 106371-106371
- DOI
  10.1016/j.eplepsyres.2020.106371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589
[Journal Article] Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy2019
- Author(s)
  Iida Madoka、Sahashi Kentaro、Kondo Naohide、Nakatsuji Hideaki、Tohnai Genki、Tsutsumi Yutaka、Noda Seiya、Murakami Ayuka、Onodera Kazunari、Okada Yohei、Nakatochi Masahiro、Tsukagoshi Okabe Yuka、Shimizu Shinobu、Mizuno Masaaki、Adachi Hiroaki、Okano Hideyuki、Sobue Gen、Katsuno Masahisa
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 4262-4262
- DOI
  10.1038/s41467-019-12282-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07970, KAKENHI-PROJECT-18K16656, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-17J40128, KAKENHI-PROJECT-18K15361
[Journal Article] DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes52019
- Author(s)
  Kondo N, Tohnai G, Sahashi K, Iida M, Kataoka M, Nakatsuji H, Tsutsumi Y, Hashizume A, Adachi H, Koike H, Shinjo K, Kondo Y, Sobue G, Katsuno M.
- Journal Title
  
  EMBO Mol Med
  
  Volume: none Issue: 5
- DOI
  10.15252/emmm.201708547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05708, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-19K07970, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-17J40128, KAKENHI-PROJECT-18K15361
[Journal Article] Preclinical progression of neurodegenerative diseases.2018
- Author(s)
  Katsuno M, Sahashi K, Iguchi Y, Hashizume A
- Journal Title
  
  Nagoya J Med Sci
  
  Volume: 80 Pages: 289-298
- NAID
  120006502462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09753
[Journal Article] 特集認知症･神経変性疾患の克服への挑戦 Ⅱ.分子標的治療の確立を目指して変異タンパク質凝集体への治療的アプローチ2016
- Author(s)
  佐橋健太郎、祖父江元
- Journal Title
  
  生体の科学
  
  Volume: 67 Issue: 4 Pages: 296-302
- DOI
  10.11477/mf.2425200457
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2016-08-15
- Data Source
  KAKENHI-PROJECT-26461268
[Journal Article] Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.2015
- Author(s)
  Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24(21) Issue: 21 Pages: 5985-94
- DOI
  10.1093/hmg/ddv300
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461268, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26860665, KAKENHI-PROJECT-26293206
[Patent] UNA OLIGOMERS FOR THE TREATMENT OF POLYGLUTAMINE DISEASES2020
- Inventor(s)
  Hirunagi T, Sahashi K, et al
- Industrial Property Rights Holder
  Hirunagi T, Sahashi K, et al
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20H00527
[Presentation] Single cell analysis reveals oligodendrocyte heterogeneity in spinal and bulbar muscular atrophy2023
- Author(s)
  飯田円, 佐橋健太郎, 蛭薙智紀, 榊原健二, 前田憲多郎, 紅朋浩, 日野原邦彦, 勝野雅央
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00420
[Presentation] A longitudinal cohort study of adults with spinal muscular atrophy (jREACT-SMA)2022
- Author(s)
  佐橋健太郎
- Organizer
  第63回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] Japan REgistry for Adult subjeCTs of spinal muscular atrophy (jREACT-SMA): Baseline characteristics2022
- Author(s)
  佐橋健太郎
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] Japan REgistry for Adult subjeCTs of spinal muscular atrophy (jREACT-SMA): A study protocol2021
- Author(s)
  佐橋健太郎
- Organizer
  第39回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] SMAの核酸治療開発とその先2021
- Author(s)
  佐橋健太郎
- Organizer
  第39回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] Japan REgistry for Adult subjeCTs of spinal muscular atrophy (jREACT-SMA): A study protocol2021
- Author(s)
  佐橋健太郎
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] 神経スプライシング治療に向けた核酸開発2020
- Author(s)
  佐橋健太郎
- Organizer
  第43回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] 脊髄性筋萎縮症の核酸治療研究から臨床適用へ2020
- Author(s)
  佐橋健太郎
- Organizer
  第61回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03545
[Presentation] Presymptomatic exercise attenuates motor dysfunction in a mouse model of SBMA.2020
- Author(s)
  蛭薙智紀，中辻秀朗，佐橋健太郎，藤内玄規，飯田円，山田晋一郎，村上あゆ香，野田成哉，勝野雅央
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00527
[Presentation] Filamin-A as a novel driver for progressive supra nuclear palsy2019
- Author(s)
  Koyo Tsujikawa, kohei Hamanaka, Mari Yoshida, Kentaro Sahashi, Satoko Miyatake, Satomi Mihashi, Yohei Iguchi, Yuichi Riku, Shinsuke Ishigaki, Gen Sobue, Naomichi Matsumoto, Masahisa Katsuno
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Akt signaling pathway is dysregulated in polyglutamine diseases.2017
- Author(s)
  Madoka Iida, Kentaro Sahashi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai, Yutaka Tsutsumi, Hiroaki Adachi, Gen Sobue, Masahisa Katsuno
- Organizer
  第58回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04195
[Presentation] Akt signaling pathway is dysregulated in polyglutamine diseases.2017
- Author(s)
  Madoka Iida, Kentaro Sahashi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai, Yutaka Tsutsumi, Hiroaki Adachi, Gen Sobue, Masahisa Katsuno
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04195
[Presentation] Dysregulated Akt signaling pathway in spinal and bulbar muscular atrophy (SBMA)2016
- Author(s)
  飯田円，勝野雅央，佐橋健太郎，中辻秀朗，近藤直英，藤内玄規，祖父江元
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県　横浜市)
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] The effect of exercise in a mouse model of spinal and bulbar muscular atrophy.2016
- Author(s)
  中辻秀朗, 勝野雅央, 近藤直英, 藤内玄規, 佐橋健太郎, 飯田円, 祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県　神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Dysregulated Akt signaling pathway in spinal and bulbar muscular atrophy (SBMA).2016
- Author(s)
  飯田円，勝野雅央，佐橋健太郎，中辻秀朗，近藤直英，藤内玄規，祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県　神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Dissection of mechanisms of neuronal degeneration in polyglutamine disease2016
- Author(s)
  Kentaro Sahashi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai, Madoka Iida, Masahisa Katsuno, and Gen Sobue
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461268
[Presentation] Dissection of mechanisms of neuronal degeneration in polyglutamine disease.2016
- Author(s)
  佐橋健太郎, 近藤直英, 中辻秀朗, 藤内玄規, 飯田円, 勝野雅央, 祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県　神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Antisense inhibition of neuronal androgen receptor in spinal and bulbar muscular atrophy2016
- Author(s)
  Kentaro Sahashi, Masahisa Katsuno, Gene Hung, Hiroaki Adachi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai, Madoka Iida, C. Frank Bennett, and Gen Sobue
- Organizer
  第8回NAGOYAグローバルリトリート
- Place of Presentation
  あいち健康プラザ(愛知県知多郡)
- Year and Date
  2016-02-12
- Data Source
  KAKENHI-PROJECT-26461268
[Presentation] 神経変性疾患モデルにおけるタクロリムスとその誘導体の治療効果2016
- Author(s)
  藤内玄規, 勝野雅央, 足立弘明, 佐橋健太郎, 近藤直英, 中辻秀朗, 飯田円, 祖父江元
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県　横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Cell cycle inhibitor ameliorates motor neuron degeneration induced by polyglutamine-expanded androgen receptor.2015
- Author(s)
  Katsuno M, Adachi H, Sahashi K, Kondo N, Iida M, Nakatsuji H, Tohnai G, Sobue G.
- Organizer
  The 26th International Symposium on ALS/MND
- Place of Presentation
  Orland, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] 球脊髄性筋萎縮症モデルにおけるタクロリムス誘導体の治療効果2015
- Author(s)
  藤内玄規, 足立弘明, 勝野雅央, 佐橋健太郎, 近藤直英, 中辻秀朗, 飯田円, 祖父江元.
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Intracerebroventricular administration of antisense oligonucleotides improves disease phenotypes in SBMA mice.2015
- Author(s)
  Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県新潟市)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Silencing neuronal mutant AR suppresses neuropathogenesis in a SBMA mo use model2015
- Author(s)
  佐橋健太郎
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟県新潟市(新潟コンベンションセンター)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461268
[Presentation] Antisense inhibition of neuronal androgen receptor in spinal and bulbar muscular atrophy.2015
- Author(s)
  Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26293206
[Presentation] Antisense inhibition of neuronal androgen receptor in spinal and bulbar muscular atrophy2015
- Author(s)
  Kentaro Sahashi, Masahisa Katsuno, Gene Hung, Hiroaki Adachi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai, Madoka Iida, C. Frank Bennett, and Gen Sobue
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26461268
[Presentation] アンチセンス核酸を用いた球脊髄性筋萎縮症の病態，治療研究2014
- Author(s)
  佐橋健太郎
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡県福岡市(福岡国際会議場)
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26461268

1. KATSUNO Masahisa (50402566)

# of Collaborated Projects: 18 results

# of Collaborated Products: 26 results
2. IGUCHI YOHEI (80790659)

# of Collaborated Projects: 11 results

# of Collaborated Products: 6 results
3. 横井聡 (30815460)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. 蛭薙智紀 (00927527)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. Sobue Gen (20148315)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
6. OKADA Yohei (30383714)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. KONDO Naohide (20725527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. 飯田円 (40815437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. 橋詰淳 (00637689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤内玄規 (00748353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 阿部洋 (80415067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 浅沼浩之 (20282577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Bennett C. Frank

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. ADACHI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 伊藤卓治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sahashi Kentaro 佐橋 健太郎

Research Projects

Research Products

Co-Researchers

運動ニューロン疾患の神経変性因子に対する標的治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next-generation antisense therapeutics for neurological diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of early axonal pathology in motor neuron diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic development against protein aggregationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of defective developmental gene regulation responsible for motor neuron degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of intrinsic readthrough mechanisms of nonsense mutations for its therapeutic applicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sahashi Kentaro 佐橋健太郎